SIMILAR PATTERNS OF AMINO ACIDS FOR 4OGR_I_ADNI401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  10
VAL A  18
ALA A  31
CYH A  83
ASP A  86
ASN A 131
LEU A 133
 None
 0.61A 4ogrI-1h4lA:
30.8		 4ogrI-1h4lA:
41.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ILE A 201
VAL A 209
ALA A 220
ASN A 319
LEU A 321
ASP A 332
 None
 0.61A 4ogrI-1k9aA:
18.5		 4ogrI-1k9aA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 580
GLY A 744
ALA A 606
ASP A 661
ASN A 729
LEU A 731
 None
 0.88A 4ogrI-1lufA:
22.8		 4ogrI-1lufA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 580
GLY A 744
ASP A 661
ASN A 729
LEU A 731
ASP A 742
 None
 0.99A 4ogrI-1lufA:
22.8		 4ogrI-1lufA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 580
VAL A 588
ALA A 606
ASP A 661
ASN A 729
LEU A 731
 None
 0.91A 4ogrI-1lufA:
22.8		 4ogrI-1lufA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  73
VAL A  78
ALA A  91
ASN A 191
LEU A 193
ASP A 207
 STU  A 401 (-3.6A)
STU  A 401 (-4.7A)
STU  A 401 (-3.4A)
STU  A 401 (-4.5A)
STU  A 401 (-4.7A)
STU  A 401 (-3.6A)
 0.83A 4ogrI-1nxkA:
22.3		 4ogrI-1nxkA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 ILE A 211
GLY A 214
VAL A 219
ALA A 230
ASN A 338
LEU A 340
 PY1  A 700 (-3.6A)
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
None
PY1  A 700 (-4.4A)
 0.91A 4ogrI-1py5A:
25.7		 4ogrI-1py5A:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 831
ALA A 642
CYH A 694
ASP A 698
ASN A 816
LEU A 818
 None
 0.96A 4ogrI-1rjbA:
21.0		 4ogrI-1rjbA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 831
CYH A 694
ASP A 698
ASN A 816
LEU A 818
ASP A 829
 None
 1.05A 4ogrI-1rjbA:
21.0		 4ogrI-1rjbA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
CYH A 694
ASP A 698
ASN A 816
LEU A 818
 None
 0.76A 4ogrI-1rjbA:
21.0		 4ogrI-1rjbA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 603
ALA A 621
CYH A 673
ASP A 677
ASN A 797
LEU A 799
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.5A)
None
None
STI  A   3 (-4.4A)
 0.52A 4ogrI-1t46A:
17.5		 4ogrI-1t46A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  34
VAL A  42
ALA A  55
CYH A 108
ASN A 156
LEU A 158
ASP A 169
 None
 0.53A 4ogrI-1u5qA:
28.5		 4ogrI-1u5qA:
29.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 ILE A  10
GLY A  13
VAL A  18
ALA A  30
ASP A  85
ASN A 130
LEU A 132
 None
 0.84A 4ogrI-1v0bA:
30.1		 4ogrI-1v0bA:
39.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A  18
ALA A  30
ASP A  85
ASN A 130
LEU A 132
ASP A 143
 None
 0.75A 4ogrI-1v0bA:
30.1		 4ogrI-1v0bA:
39.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  18
VAL A  23
ALA A  36
CYH A  87
ASN A 135
LEU A 137
ASP A 148
 HYM  A 400 ( 3.7A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.60A 4ogrI-1zltA:
28.2		 4ogrI-1zltA:
29.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  34
VAL A  42
ALA A  55
CYH A 108
ASN A 156
LEU A 158
ASP A 169
 STU  A 400 (-4.2A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 (-4.0A)
STU  A 400 (-4.4A)
STU  A 400 ( 4.6A)
STU  A 400 (-3.6A)
 0.44A 4ogrI-2gcdA:
28.5		 4ogrI-2gcdA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 383
VAL A 256
ALA A 269
ASN A 368
LEU A 370
ASP A 381
 None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-4.9A)
 0.90A 4ogrI-2hz0A:
24.7		 4ogrI-2hz0A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 ILE A 428
VAL A 436
ALA A 452
CYH A 502
ASN A 551
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-4.1A)
None
4ST  A1687 (-4.4A)
 0.61A 4ogrI-2j0jA:
23.2		 4ogrI-2j0jA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  13
VAL A  18
ALA A  31
ASP A  86
ASN A 132
LEU A 134
ASP A 145
 None
 0.84A 4ogrI-2jgzA:
36.4		 4ogrI-2jgzA:
42.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  10
GLY A  13
VAL A  18
ALA A  31
ASN A 132
LEU A 134
ASP A 145
 None
 0.76A 4ogrI-2jgzA:
36.4		 4ogrI-2jgzA:
42.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 428
GLY A 431
VAL A 436
ALA A 452
CYH A 502
LEU A 553
 BII  A1687 (-3.8A)
BII  A1687 ( 4.1A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-4.1A)
BII  A1687 (-4.2A)
 0.42A 4ogrI-2jkmA:
23.4		 4ogrI-2jkmA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 596
ALA A 614
CYH A 666
ASP A 670
ASN A 783
LEU A 785
 None
 0.75A 4ogrI-2ogvA:
21.2		 4ogrI-2ogvA:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 199
VAL A 204
ALA A 215
ASN A 326
LEU A 328
ASP A 339
 None
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.4A)
None
 0.74A 4ogrI-2qluA:
26.8		 4ogrI-2qluA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  82
VAL A  90
ALA A 103
ASP A 160
ASN A 203
LEU A 205
 None
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.0A)
MG  A1481 (-3.5A)
ANP  A1480 ( 4.7A)
 0.89A 4ogrI-2v55A:
25.0		 4ogrI-2v55A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  77
VAL A  85
ALA A  98
ASN A 200
LEU A 202
ASP A 213
 BI8  A1417 (-4.1A)
BI8  A1417 ( 4.7A)
BI8  A1417 ( 3.8A)
BI8  A1417 (-3.6A)
BI8  A1417 (-4.8A)
BI8  A1417 (-3.8A)
 0.78A 4ogrI-2vd5A:
25.6		 4ogrI-2vd5A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		7 ILE A 490
VAL A 498
ALA A 509
ASP A 611
ASN A 654
LEU A 656
ASP A 687
 None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
5ID  A1800 (-3.6A)
None
5ID  A1800 (-4.5A)
IOD  A1799 (-4.0A)
 0.71A 4ogrI-2vuwA:
12.2		 4ogrI-2vuwA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  29
VAL A  34
ALA A  47
ASN A 145
LEU A 147
ASP A 158
 J60  A1294 ( 4.5A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.62A 4ogrI-2xikA:
21.7		 4ogrI-2xikA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 305
VAL A 313
ALA A 326
CYH A 379
ASN A 431
ASP A 463
 770  A 901 (-3.8A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
None
770  A 901 (-3.8A)
 0.62A 4ogrI-2z2wA:
26.3		 4ogrI-2z2wA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  71
VAL A  76
ALA A  92
ASP A 148
ASN A 192
LEU A 194
 STU  A   1 ( 4.1A)
None
STU  A   1 (-3.3A)
STU  A   1 (-3.8A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
 1.00A 4ogrI-2z7rA:
24.3		 4ogrI-2z7rA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  76
ALA A  92
ASP A 148
ASN A 192
LEU A 194
ASP A 205
 None
STU  A   1 (-3.3A)
STU  A   1 (-3.8A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.75A 4ogrI-2z7rA:
24.3		 4ogrI-2z7rA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A1005
VAL A1010
ALA A1028
ASP A1083
ASN A1137
ASP A1150
 None
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 (-3.7A)
None
None
 0.99A 4ogrI-2z8cA:
17.9		 4ogrI-2z8cA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 201
VAL A 209
ALA A 220
ASN A 319
LEU A 321
ASP A 332
 None
 0.61A 4ogrI-3d7uA:
26.4		 4ogrI-3d7uA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  23
VAL A  31
ALA A  44
ASN A 151
LEU A 153
ASP A 164
 ANP  A   1 (-4.2A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 ( 3.4A)
None
ANP  A   1 (-3.8A)
 0.99A 4ogrI-3dakA:
21.3		 4ogrI-3dakA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  52
ALA A  65
ASP A 128
ASN A 172
LEU A 174
ASP A 186
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 (-4.7A)
985  A   1 (-4.6A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.70A 4ogrI-3f2aA:
13.8		 4ogrI-3f2aA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 ILE A  16
GLY A  19
VAL A  24
ALA A  37
CYH A  92
LEU A 182
 ANP  A 329 ( 4.2A)
ANP  A 329 (-3.3A)
ANP  A 329 (-4.4A)
ANP  A 329 ( 3.7A)
ANP  A 329 (-4.1A)
ANP  A 329 (-4.4A)
 0.86A 4ogrI-3hkoA:
25.2		 4ogrI-3hkoA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 GLY A  85
VAL A  90
ALA A 103
ASN A 204
LEU A 206
ASP A 220
 GOL  A 542 ( 4.8A)
None
J60  A 540 (-3.6A)
GOL  A 542 ( 4.8A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.74A 4ogrI-3hztA:
20.6		 4ogrI-3hztA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 GLY A 683
VAL A 689
ALA A 700
CYH A 748
ASN A 802
LEU A 804
 ADP  A2101 (-3.3A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 (-4.2A)
MG  A2102 ( 2.9A)
ADP  A2101 (-4.4A)
 1.00A 4ogrI-3lj0A:
24.6		 4ogrI-3lj0A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 ILE A 210
GLY A 213
VAL A 218
ALA A 229
ASN A 337
LEU A 339
ASP A 350
 LDN  A   1 (-4.1A)
LDN  A   1 ( 4.4A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-4.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.58A 4ogrI-3mdyA:
27.2		 4ogrI-3mdyA:
27.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  25
VAL A  33
ALA A  46
CYH A 106
ASP A 109
ASN A 154
LEU A 156
ASP A 167
 None
 0.69A 4ogrI-3mi9A:
45.5		 4ogrI-3mi9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 VAL A 200
ALA A 213
ASP A 270
ASN A 316
LEU A 318
ASP A 329
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-3.6A)
AMP  A 577 (-4.2A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.67A 4ogrI-3nyoA:
28.1		 4ogrI-3nyoA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 729
VAL A 734
ALA A 751
ASN A 850
LEU A 852
ASP A 863
 03Q  A   1 (-3.3A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.55A 4ogrI-3pp0A:
25.8		 4ogrI-3pp0A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ILE A 557
VAL A 565
ALA A 576
ASN A 681
LEU A 683
ASP A 694
 STU  A   1 (-4.1A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.6A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.76A 4ogrI-3ppzA:
27.4		 4ogrI-3ppzA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 201
VAL A 206
ALA A 217
ASN A 327
LEU A 329
ASP A 340
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
None
 0.67A 4ogrI-3q4tA:
26.4		 4ogrI-3q4tA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
GLY A  85
VAL A  90
ASP A 160
ASN A 205
LEU A 207
ASP A 218
 None
None
NM7  A 416 (-3.7A)
None
None
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.91A 4ogrI-3qfvA:
25.6		 4ogrI-3qfvA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
VAL A  90
ALA A 103
ASP A 160
ASN A 205
LEU A 207
ASP A 218
 None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
None
None
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.69A 4ogrI-3qfvA:
25.6		 4ogrI-3qfvA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  53
VAL A  58
ALA A  71
ASN A 171
LEU A 173
ASP A 187
 I85  A 350 (-3.1A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
I85  A 350 (-4.4A)
None
I85  A 350 (-3.3A)
 0.67A 4ogrI-3sheA:
21.1		 4ogrI-3sheA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A 369
ALA A 382
ASP A 440
ASN A 484
LEU A 486
ASP A 497
 07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.9A)
None
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.69A 4ogrI-3txoA:
16.5		 4ogrI-3txoA:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  10
VAL A  18
ALA A  31
CYH A  83
ASN A 131
LEU A 133
 D15  A 500 (-4.2A)
D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 (-4.3A)
D15  A 500 (-3.0A)
D15  A 500 (-4.5A)
 0.55A 4ogrI-4aguA:
31.6		 4ogrI-4aguA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ILE A  83
VAL A  91
ALA A 104
ASP A 161
ASN A 206
LEU A 208
ASP A 219
 None
None
EDO  A1420 (-3.4A)
None
None
EDO  A1420 ( 4.8A)
None
 0.77A 4ogrI-4aw2A:
25.4		 4ogrI-4aw2A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 GLY A  25
VAL A  30
ALA A  43
ASN A 144
LEU A 146
ASP A 157
 STU  A1550 (-3.8A)
None
STU  A1550 (-3.1A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.81A 4ogrI-4cfhA:
28.3		 4ogrI-4cfhA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A 671
ALA A 684
ASP A 744
ASN A 787
LEU A 789
ASP A 800
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.0A)
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.69A 4ogrI-4crsA:
26.5		 4ogrI-4crsA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ILE A 567
ALA A 588
ASP A 643
ASN A 688
LEU A 690
ASP A 701
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.6A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.77A 4ogrI-4e93A:
27.0		 4ogrI-4e93A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 ILE A 567
GLY A 570
VAL A 575
ALA A 588
ASP A 643
ASN A 688
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.6A)
GUI  A 901 (-4.3A)
 0.78A 4ogrI-4e93A:
27.0		 4ogrI-4e93A:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  19
VAL A  27
ALA A  41
ASP A 104
LEU A 152
ASP A 163
 0RS  A 900 (-4.1A)
None
0RS  A 900 ( 3.7A)
0RS  A 900 (-4.2A)
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
 0.81A 4ogrI-4ez5A:
23.0		 4ogrI-4ez5A:
37.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  41
ASP A 104
ASN A 150
LEU A 152
ASP A 163
 None
0RS  A 900 ( 3.7A)
0RS  A 900 (-4.2A)
None
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
 0.90A 4ogrI-4ez5A:
23.0		 4ogrI-4ez5A:
37.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  64
VAL A  72
ALA A  88
ASN A 182
LEU A 184
ASP A 196
 None
ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
MG  A 602 ( 2.6A)
ADP  A 601 ( 4.9A)
MG  A 602 ( 3.1A)
 0.58A 4ogrI-4f99A:
24.5		 4ogrI-4f99A:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  29
VAL A  37
ALA A  50
ASP A 107
ASN A 151
LEU A 153
ASP A 164
 STU  A 401 (-4.1A)
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
STU  A 401 (-3.3A)
STU  A 401 ( 4.8A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.75A 4ogrI-4fr4A:
26.8		 4ogrI-4fr4A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY A 411
VAL A 416
ALA A 429
ASN A 522
LEU A 524
ASP A 536
 0WB  A 701 (-3.6A)
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-4.1A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.55A 4ogrI-4g3fA:
26.6		 4ogrI-4g3fA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 409
VAL A 414
ALA A 427
ASN A 520
LEU A 522
ASP A 534
 T28  A 701 ( 3.0A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 4.9A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.60A 4ogrI-4idtA:
26.6		 4ogrI-4idtA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A  45
VAL A  50
ALA A  61
ASN A 161
LEU A 163
ASP A 175
 1UL  A 501 ( 3.7A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.76A 4ogrI-4l52A:
17.7		 4ogrI-4l52A:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		6 ILE A 369
ALA A 388
CYH A 435
ASN A 487
LEU A 489
ASP A 500
 None
 0.85A 4ogrI-4o1oA:
11.2		 4ogrI-4o1oA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  54
ALA A  67
CYH A 126
ASN A 178
LEU A 180
ASP A 191
 None
SIN  A 401 ( 3.7A)
SIN  A 401 (-4.3A)
None
SIN  A 401 ( 4.5A)
None
 0.70A 4ogrI-4o38A:
15.1		 4ogrI-4o38A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		6 ILE B 371
ALA B 390
CYH B 437
ASN B 490
LEU B 492
ASP B 503
 ACP  B 801 (-4.2A)
ACP  B 801 (-3.2A)
ACP  B 801 (-4.5A)
MG  B 802 ( 2.5A)
ACP  B 801 (-4.5A)
MG  B 803 (-1.8A)
 0.58A 4ogrI-4oavB:
19.0		 4ogrI-4oavB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 906
VAL A 911
ALA A 928
ASN A1028
LEU A1030
ASP A1041
 2TT  A1202 ( 3.8A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.5A)
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.74A 4ogrI-4oliA:
26.3		 4ogrI-4oliA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A 635
ALA A 648
ASP A 708
ASN A 751
LEU A 753
ASP A 764
 None
 0.77A 4ogrI-4otdA:
26.2		 4ogrI-4otdA:
26.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		6 ILE A  27
VAL A  35
ALA A  49
ASP A 110
ASN A 154
LEU A 156
 ANP  A 402 (-4.6A)
ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-3.4A)
MG  A 401 ( 2.7A)
ANP  A 402 (-4.6A)
 0.73A 4ogrI-4qnyA:
31.6		 4ogrI-4qnyA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  48
VAL A  56
ALA A  69
ASP A 128
ASN A 171
LEU A 173
 38Z  A 418 ( 4.4A)
None
38Z  A 418 (-3.4A)
EDO  A 413 (-2.9A)
None
38Z  A 418 (-4.4A)
 0.65A 4ogrI-4qtbA:
31.2		 4ogrI-4qtbA:
31.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 GLY A  27
VAL A  32
ALA A  45
ASN A 146
LEU A 148
ASP A 159
 STU  A 601 (-3.4A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.2A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.70A 4ogrI-4rewA:
27.5		 4ogrI-4rewA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
CYH A 694
ASP A 698
ASN A 816
LEU A 818
 None
P30  A1001 (-3.4A)
None
None
None
P30  A1001 (-4.6A)
 0.75A 4ogrI-4rt7A:
17.3		 4ogrI-4rt7A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 150
GLY A 153
VAL A 158
ALA A 169
ASN A 273
LEU A 275
ASP A 294
 None
 0.67A 4ogrI-4uy9A:
22.5		 4ogrI-4uy9A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  60
ALA A  72
CYH A 129
ASN A 181
LEU A 183
ASP A 194
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 (-4.5A)
KSA  A 405 (-4.0A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.57A 4ogrI-4wsqA:
24.7		 4ogrI-4wsqA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
CYH A 694
ASP A 698
ASN A 816
LEU A 818
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-4.2A)
None
None
P30  A1001 (-4.3A)
 0.81A 4ogrI-4xufA:
15.8		 4ogrI-4xufA:
29.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  13
VAL A  18
ALA A  31
ASP A  86
ASN A 133
LEU A 135
 None
 0.86A 4ogrI-4yc6A:
30.4		 4ogrI-4yc6A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  18
ALA A  31
ASP A  86
ASN A 133
LEU A 135
ASP A 146
 None
 0.89A 4ogrI-4yc6A:
30.4		 4ogrI-4yc6A:
40.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 469
VAL A 477
ALA A 488
ASN A 593
LEU A 595
ASP A 606
 4CV  A 801 (-4.3A)
None
4CV  A 801 (-3.5A)
None
4CV  A 801 (-4.4A)
4CV  A 801 (-3.5A)
 0.47A 4ogrI-4yffA:
23.1		 4ogrI-4yffA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 165
VAL A 173
ALA A 186
ASN A 292
LEU A 294
ASP A 307
 4E1  A 505 ( 4.6A)
4E1  A 505 (-4.5A)
4E1  A 505 (-3.5A)
None
None
4E1  A 505 (-3.6A)
 0.68A 4ogrI-4yljA:
29.7		 4ogrI-4yljA:
27.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  22
VAL A  30
ALA A  44
CYH A  95
ASN A 143
LEU A 145
 51W  A 401 (-3.9A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
GOL  A 404 ( 4.6A)
51W  A 401 (-4.5A)
 0.63A 4ogrI-5ci7A:
27.1		 4ogrI-5ci7A:
31.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
ALA A  44
CYH A  95
ASP A  99
ASN A 143
LEU A 145
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
51W  A 401 (-3.8A)
GOL  A 404 ( 4.6A)
51W  A 401 (-4.5A)
 0.73A 4ogrI-5ci7A:
27.1		 4ogrI-5ci7A:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  34
VAL A  39
ALA A  52
ASN A 158
LEU A 160
ASP A 171
 GLY  A  34 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
ASN  A 158 ( 0.6A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
 0.53A 4ogrI-5d7aA:
26.7		 4ogrI-5d7aA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 ILE A  62
VAL A  70
ALA A  83
ASN A 183
LEU A 185
ASP A 196
 5RC  A4000 (-4.0A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-4.1A)
None
5RC  A4000 (-3.6A)
 0.90A 4ogrI-5es1A:
25.3		 4ogrI-5es1A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 906
VAL A 911
ALA A 928
ASN A1028
LEU A1030
ASP A1041
 5U3  A1200 ( 4.4A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.7A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.52A 4ogrI-5f1zA:
26.8		 4ogrI-5f1zA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 463
VAL A 471
ALA A 481
CYH A 532
ASN A 581
ASP A 594
 5XJ  A 801 ( 4.7A)
5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-4.6A)
None
None
 0.67A 4ogrI-5fd2A:
17.0		 4ogrI-5fd2A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 607
ALA A 625
CYH A 677
ASP A 681
ASN A 823
LEU A 825
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.5A)
None
None
748  A1001 (-4.3A)
 0.69A 4ogrI-5grnA:
15.8		 4ogrI-5grnA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  65
ALA A  77
CYH A 133
ASN A 185
LEU A 187
ASP A 198
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-4.6A)
IDV  A 401 (-4.1A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.50A 4ogrI-5i3oA:
24.7		 4ogrI-5i3oA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 GLY A  25
VAL A  30
ALA A  43
ASN A 144
LEU A 146
ASP A 157
 STU  A 601 (-3.7A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.57A 4ogrI-5isoA:
27.7		 4ogrI-5isoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  22
GLY A  25
VAL A  30
ALA A  43
CYH A  93
ASN A 141
LEU A 143
ASP A 154
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.6A)
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
TPO  A 145 (-4.1A)
None
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.50A 4ogrI-5j5tA:
25.9		 4ogrI-5j5tA:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 404
ALA A 417
ASP A 472
ASN A 516
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-4.4A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.77A 4ogrI-5jznA:
26.5		 4ogrI-5jznA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  41
VAL A  49
ALA A  60
ASN A 161
LEU A 163
ASP A 174
 STU  A 901 (-4.3A)
None
STU  A 901 (-3.3A)
STU  A 901 ( 4.8A)
STU  A 901 (-4.5A)
STU  A 901 (-4.1A)
 0.76A 4ogrI-5lohA:
22.7		 4ogrI-5lohA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  49
ALA A  60
ASP A 117
ASN A 161
LEU A 163
ASP A 174
 None
STU  A 901 (-3.3A)
STU  A 901 (-4.2A)
STU  A 901 ( 4.8A)
STU  A 901 (-4.5A)
STU  A 901 (-4.1A)
 0.78A 4ogrI-5lohA:
22.7		 4ogrI-5lohA:
27.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 155
VAL A 163
ALA A 176
ASN A 280
LEU A 282
ASP A 295
 7A7  A 501 ( 4.3A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.8A)
7A7  A 501 (-4.9A)
7A7  A 501 (-3.2A)
 0.64A 4ogrI-5lxdA:
29.2		 4ogrI-5lxdA:
31.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 6 ILE A 358
VAL A 366
ALA A 379
ASP A 436
ASN A 480
LEU A 482
 ANP  A 801 (-4.2A)
ANP  A 801 (-4.7A)
ANP  A 801 ( 3.9A)
ANP  A 801 (-3.4A)
ANP  A 801 (-3.8A)
ANP  A 801 (-4.8A)
 0.79A 4ogrI-5nclA:
21.0		 4ogrI-5nclA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 6 VAL A  52
ALA A  65
ASP A 128
ASN A 172
LEU A 174
ASP A 186
 7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
7LK  A 401 ( 3.9A)
None
7LK  A 401 (-4.8A)
None
 0.75A 4ogrI-5turA:
27.0		 4ogrI-5turA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 106
ALA A 119
ASP A 176
ASN A 219
LEU A 221
ASP A 232
 None
 0.85A 4ogrI-5u7qA:
25.8		 4ogrI-5u7qA:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 218
GLY A 221
VAL A 226
ALA A 239
CYH A 292
ASN A 344
 8X7  A 501 ( 4.0A)
8X7  A 501 (-3.4A)
8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-3.8A)
8X7  A 501 ( 4.7A)
 0.76A 4ogrI-5vdkA:
26.0		 4ogrI-5vdkA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 6 GLY A 689
VAL A 694
ALA A 707
ASN A 808
LEU A 810
ASP A 822
 9E1  A1001 (-2.9A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.50A 4ogrI-5vilA:
22.5		 4ogrI-5vilA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 6 VAL A 223
ALA A 236
ASP A 294
ASN A 340
LEU A 342
ASP A 355
 HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
None
None
None
HRM  A 601 (-4.7A)
 0.74A 4ogrI-5y86A:
23.8		 4ogrI-5y86A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 7 ILE A 733
VAL A 741
ALA A 754
ASP A 819
ASN A 864
LEU A 866
ASP A 877
 CJM  A1102 (-3.4A)
None
CJM  A1102 (-3.1A)
CJM  A1102 (-4.1A)
MG  A1101 ( 4.4A)
CJM  A1102 (-4.4A)
MG  A1101 (-2.5A)
 0.48A 4ogrI-6b3eA:
40.0		 4ogrI-6b3eA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 6 ILE A  66
VAL A  74
ALA A  87
ASN A 187
LEU A 189
ASP A 200
 None
 0.89A 4ogrI-6c9dA:
27.0		 4ogrI-6c9dA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 ILE A 171
GLY A 174
VAL A 179
ALA A 192
ASN A 317
LEU A 319
ASP A 330
 F6J  A 501 (-4.3A)
F6J  A 501 (-3.5A)
F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 ( 4.7A)
F6J  A 501 (-4.5A)
F6J  A 501 (-3.8A)
 0.73A 4ogrI-6cmjA:
27.5		 4ogrI-6cmjA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 6 ALA U  42
CYH U  94
ASP U  98
ASN U 142
LEU U 144
ASP U 157
 DB8  U 301 (-3.6A)
DB8  U 301 (-4.2A)
None
DB8  U 301 (-4.5A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.68A 4ogrI-6fdyU:
25.7		 4ogrI-6fdyU:
undetectable