SIMILAR PATTERNS OF AMINO ACIDS FOR 4OGR_E_ADNE401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byo PROTEIN
(PLASTOCYANIN)

(Silene
latifolia) 		PF00127
(Copper-bind) 		5 GLY A  94
ALA A  88
ASP A  39
LEU A  40
ASP A  42
 None
 1.48A 4ogrE-1byoA:
undetectable		 4ogrE-1byoA:
14.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
CYH A  83
ASP A  86
ASN A 131
LEU A 133
 None
 0.51A 4ogrE-1h4lA:
30.0		 4ogrE-1h4lA:
41.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 606
ASP A 661
ASN A 729
LEU A 731
ASP A 742
 None
 0.89A 4ogrE-1lufA:
22.6		 4ogrE-1lufA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  71
ALA A  91
ASN A 191
LEU A 193
ASP A 207
 STU  A 401 (-3.6A)
STU  A 401 (-3.4A)
STU  A 401 (-4.5A)
STU  A 401 (-4.7A)
STU  A 401 (-3.6A)
 0.97A 4ogrE-1nxkA:
21.4		 4ogrE-1nxkA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
CYH A 694
ASP A 698
ASN A 816
LEU A 818
ASP A 829
 None
 0.88A 4ogrE-1rjbA:
21.1		 4ogrE-1rjbA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 617
ALA A 642
CYH A 694
ASP A 698
LEU A 818
 None
 0.94A 4ogrE-1rjbA:
21.1		 4ogrE-1rjbA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 596
ALA A 621
CYH A 673
ASP A 677
ASN A 797
LEU A 799
 None
STI  A   3 (-3.5A)
STI  A   3 (-4.5A)
None
None
STI  A   3 (-4.4A)
 0.67A 4ogrE-1t46A:
17.4		 4ogrE-1t46A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 345
ALA A 367
ASN A 466
LEU A 468
ASP A 479
 STU  A 100 (-3.3A)
STU  A 100 (-3.2A)
STU  A 100 (-4.2A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.71A 4ogrE-1u59A:
25.2		 4ogrE-1u59A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 GLY A  35
ALA A  55
CYH A 108
ASN A 156
LEU A 158
ASP A 169
 None
 0.68A 4ogrE-1u5qA:
27.7		 4ogrE-1u5qA:
29.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ALA A  30
ASP A  85
ASN A 130
LEU A 132
ASP A 143
 None
 0.72A 4ogrE-1v0bA:
29.4		 4ogrE-1v0bA:
39.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 GLY A  11
ALA A  30
ASP A  85
ASN A 130
LEU A 132
 None
 0.95A 4ogrE-1v0bA:
29.4		 4ogrE-1v0bA:
39.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  16
ALA A  36
CYH A  87
ASN A 135
LEU A 137
ASP A 148
 HYM  A 400 ( 3.8A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.80A 4ogrE-1zltA:
27.0		 4ogrE-1zltA:
29.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY X  18
ALA X  37
ASN X 135
LEU X 137
ASP X 148
 STU  X 902 ( 3.7A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.9A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.80A 4ogrE-2dq7X:
25.9		 4ogrE-2dq7X:
27.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 GLY A  20
ALA A  40
ASP A  99
ASN A 142
LEU A 144
 ADP  A 500 ( 4.1A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-3.5A)
MG  A 600 ( 2.7A)
ADP  A 500 (-4.3A)
 0.81A 4ogrE-2f9gA:
30.0		 4ogrE-2f9gA:
33.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 GLY A  35
ALA A  55
CYH A 108
ASN A 156
LEU A 158
ASP A 169
 STU  A 400 (-3.3A)
STU  A 400 (-3.2A)
STU  A 400 (-4.0A)
STU  A 400 (-4.4A)
STU  A 400 ( 4.6A)
STU  A 400 (-3.6A)
 0.63A 4ogrE-2gcdA:
27.7		 4ogrE-2gcdA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 ALA A 293
ASN A 391
LEU A 393
ASP A 404
 H8H  A 534 (-3.2A)
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.27A 4ogrE-2h8hA:
23.0		 4ogrE-2h8hA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 ALA A 452
CYH A 502
ASN A 551
LEU A 553
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 (-4.1A)
None
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.69A 4ogrE-2j0jA:
22.8		 4ogrE-2j0jA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 GLY A 429
ALA A 452
CYH A 502
LEU A 553
 4ST  A1687 (-3.1A)
4ST  A1687 (-3.3A)
4ST  A1687 (-4.1A)
4ST  A1687 (-4.4A)
 0.32A 4ogrE-2j0jA:
22.8		 4ogrE-2j0jA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  30
ALA A  50
ASN A 149
LEU A 151
ASP A 165
 None
J60  A1305 (-3.3A)
None
None
J60  A1305 ( 3.6A)
 1.09A 4ogrE-2jamA:
19.1		 4ogrE-2jamA:
26.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
ASP A  86
ASN A 132
LEU A 134
ASP A 145
 None
 0.49A 4ogrE-2jgzA:
36.0		 4ogrE-2jgzA:
42.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 452
CYH A 502
ASN A 551
LEU A 553
ASP A 564
 BII  A1687 (-3.5A)
BII  A1687 (-4.1A)
None
BII  A1687 (-4.2A)
None
 1.05A 4ogrE-2jkmA:
22.8		 4ogrE-2jkmA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 GLY A 431
ALA A 452
ASN A 551
LEU A 553
ASP A 564
 BII  A1687 ( 4.1A)
BII  A1687 (-3.5A)
None
BII  A1687 (-4.2A)
None
 1.42A 4ogrE-2jkmA:
22.8		 4ogrE-2jkmA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 614
CYH A 666
ASP A 670
ASN A 783
LEU A 785
 None
 0.73A 4ogrE-2ogvA:
21.1		 4ogrE-2ogvA:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 CYH A 666
ASP A 670
ASN A 783
LEU A 785
ASP A 796
 None
 0.69A 4ogrE-2ogvA:
21.1		 4ogrE-2ogvA:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 589
ALA A 614
CYH A 666
ASP A 670
LEU A 785
 None
 0.84A 4ogrE-2ogvA:
21.1		 4ogrE-2ogvA:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY X  71
ALA X  91
ASN X 191
LEU X 193
ASP X 207
 F10  X 401 ( 4.3A)
F10  X 401 (-3.4A)
None
F10  X 401 ( 4.4A)
F10  X 401 (-3.4A)
 1.28A 4ogrE-2p3gX:
19.4		 4ogrE-2p3gX:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		5 GLY A  26
ALA A  46
ASN A 154
LEU A 156
ASP A 167
 ATP  A 381 (-3.5A)
ATP  A 381 (-3.5A)
MN  A 383 ( 2.7A)
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.83A 4ogrE-2phkA:
26.9		 4ogrE-2phkA:
27.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ALA A  34
ASP A  88
ASN A 138
LEU A 140
ASP A 151
 AGS  A3001 (-3.5A)
None
AGS  A3001 (-3.9A)
None
AGS  A3001 (-2.8A)
 0.65A 4ogrE-2pmiA:
31.8		 4ogrE-2pmiA:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  98
ASP A 155
ASN A 200
LEU A 202
ASP A 213
 BI8  A1417 ( 3.8A)
None
BI8  A1417 (-3.6A)
BI8  A1417 (-4.8A)
BI8  A1417 (-3.8A)
 0.70A 4ogrE-2vd5A:
25.4		 4ogrE-2vd5A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		5 ALA A 509
ASP A 611
ASN A 654
LEU A 656
ASP A 687
 5ID  A1800 (-3.4A)
5ID  A1800 (-3.6A)
None
5ID  A1800 (-4.5A)
IOD  A1799 (-4.0A)
 0.46A 4ogrE-2vuwA:
16.5		 4ogrE-2vuwA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		5 GLY A 491
ALA A 509
ASP A 611
ASN A 654
LEU A 656
 5ID  A1800 (-3.5A)
5ID  A1800 (-3.4A)
5ID  A1800 (-3.6A)
None
5ID  A1800 (-4.5A)
 0.85A 4ogrE-2vuwA:
16.5		 4ogrE-2vuwA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  27
ALA A  47
ASN A 145
LEU A 147
ASP A 158
 J60  A1294 ( 4.1A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.91A 4ogrE-2xikA:
29.5		 4ogrE-2xikA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 326
CYH A 379
ASN A 431
ASP A 463
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
None
770  A 901 (-3.8A)
 0.26A 4ogrE-2z2wA:
26.2		 4ogrE-2z2wA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  92
ASP A 148
ASN A 192
LEU A 194
ASP A 205
 STU  A   1 (-3.3A)
STU  A   1 (-3.8A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.62A 4ogrE-2z7rA:
23.5		 4ogrE-2z7rA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  69
ALA A  92
ASP A 148
ASN A 192
LEU A 194
 STU  A   1 (-3.3A)
STU  A   1 (-3.3A)
STU  A   1 (-3.8A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
 0.93A 4ogrE-2z7rA:
23.5		 4ogrE-2z7rA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  65
ASP A 128
ASN A 172
LEU A 174
ASP A 186
 985  A   1 (-3.5A)
985  A   1 (-4.7A)
985  A   1 (-4.6A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.68A 4ogrE-3f2aA:
13.1		 4ogrE-3f2aA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 GLY A  83
ALA A 103
ASN A 204
LEU A 206
ASP A 220
 J60  A 540 ( 4.3A)
J60  A 540 (-3.6A)
GOL  A 542 ( 4.8A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.99A 4ogrE-3hztA:
20.0		 4ogrE-3hztA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 433
ALA A 453
ASN A 549
LEU A 551
ASP A 565
 ANP  A 400 (-3.6A)
ANP  A 400 ( 3.8A)
ANP  A 400 ( 4.4A)
ANP  A 400 (-4.7A)
None
 0.77A 4ogrE-3kn5A:
21.1		 4ogrE-3kn5A:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 ALA A 700
CYH A 748
ASN A 802
LEU A 804
ASP A 828
 ADP  A2101 (-3.5A)
ADP  A2101 (-4.2A)
MG  A2102 ( 2.9A)
ADP  A2101 (-4.4A)
SR  A2103 (-2.6A)
 0.59A 4ogrE-3lj0A:
24.1		 4ogrE-3lj0A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  40
ALA A  60
ASN A 163
LEU A 165
ASP A 179
 None
QUE  A   1 (-3.2A)
None
None
QUE  A   1 (-2.9A)
 1.00A 4ogrE-3lm5A:
27.2		 4ogrE-3lm5A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcq THIAMINE-MONOPHOSPHA
TE KINASE

(Methylobacillus
flagellatus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 GLY A 256
ALA A 165
ASP A 258
LEU A 185
ASP A 159
 None
None
PG4  A 327 (-3.1A)
PG4  A 327 ( 4.8A)
None
 1.27A 4ogrE-3mcqA:
undetectable		 4ogrE-3mcqA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		5 GLY A 211
ALA A 229
ASN A 337
LEU A 339
ASP A 350
 LDN  A   1 ( 4.7A)
LDN  A   1 (-3.6A)
LDN  A   1 (-4.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.64A 4ogrE-3mdyA:
25.7		 4ogrE-3mdyA:
27.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  46
CYH A 106
ASP A 109
ASN A 154
LEU A 156
ASP A 167
 None
 0.31A 4ogrE-3mi9A:
47.1		 4ogrE-3mi9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  26
ALA A  46
CYH A 106
ASP A 109
LEU A 156
 None
 0.99A 4ogrE-3mi9A:
47.1		 4ogrE-3mi9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 172
ALA A 192
ASP A 246
ASN A 291
LEU A 293
 FEF  A 668 ( 4.2A)
FEF  A 668 (-3.3A)
FEF  A 668 ( 4.3A)
FEF  A 668 (-3.9A)
FEF  A 668 (-4.2A)
 0.48A 4ogrE-3mtlA:
23.8		 4ogrE-3mtlA:
38.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  50
ALA A  70
ASN A 171
LEU A 173
ASP A 184
 XFE  A 351 ( 4.0A)
XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.6A)
None
 0.76A 4ogrE-3mvjA:
26.1		 4ogrE-3mvjA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 GLY A  39
ASP A 117
ASN A 161
LEU A 163
ASP A 174
 ANP  A 430 (-3.0A)
ANP  A 430 (-3.3A)
None
ANP  A 430 (-4.4A)
ANP  A 430 (-2.8A)
 1.10A 4ogrE-3nieA:
28.7		 4ogrE-3nieA:
28.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 ALA A  49
ASP A 104
ASN A 149
LEU A 151
ASP A 162
 ADP  A 314 (-3.5A)
ADP  A 314 (-4.1A)
MG  A 312 ( 2.9A)
ADP  A 314 (-4.6A)
MG  A 312 ( 3.3A)
 0.71A 4ogrE-3nizA:
31.7		 4ogrE-3nizA:
39.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 ALA A 213
ASP A 270
ASN A 316
LEU A 318
ASP A 329
 AMP  A 577 (-3.4A)
AMP  A 577 (-3.6A)
AMP  A 577 (-4.2A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.53A 4ogrE-3nyoA:
27.4		 4ogrE-3nyoA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 727
ALA A 751
ASN A 850
LEU A 852
ASP A 863
 None
03Q  A   1 (-3.1A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.66A 4ogrE-3pp0A:
24.9		 4ogrE-3pp0A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Clostridium
perfringens) 		PF00698
(Acyl_transf_1) 		5 GLY A  19
ALA A  76
ASP A 297
LEU A 298
ASP A  24
 None
 1.24A 4ogrE-3ptwA:
undetectable		 4ogrE-3ptwA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 217
ASN A 327
LEU A 329
ASP A 340
 TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
None
 0.26A 4ogrE-3q4tA:
24.9		 4ogrE-3q4tA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 103
ASP A 160
ASN A 205
LEU A 207
ASP A 218
 NM7  A 416 ( 3.7A)
None
None
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.59A 4ogrE-3qfvA:
24.6		 4ogrE-3qfvA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  83
ALA A 103
ASN A 205
LEU A 207
ASP A 218
 NM7  A 416 (-3.0A)
NM7  A 416 ( 3.7A)
None
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.64A 4ogrE-3qfvA:
24.6		 4ogrE-3qfvA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  51
ALA A  71
ASN A 171
LEU A 173
ASP A 187
 I85  A 350 (-3.5A)
I85  A 350 (-3.3A)
I85  A 350 (-4.4A)
None
I85  A 350 (-3.3A)
 0.74A 4ogrE-3sheA:
20.2		 4ogrE-3sheA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttl POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		5 GLY A 133
ALA A 312
ASP A 273
ASN A  83
LEU A 274
 None
 1.19A 4ogrE-3ttlA:
undetectable		 4ogrE-3ttlA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ALA A 382
ASP A 440
ASN A 484
LEU A 486
ASP A 497
 07U  A   1 (-3.3A)
07U  A   1 (-3.9A)
None
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.59A 4ogrE-3txoA:
16.5		 4ogrE-3txoA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpz GLUCOKINASE

(Pseudoalteromonas
sp. AS-131) 		PF02685
(Glucokinase) 		5 GLY A  17
ALA A  14
CYH A  72
ASN A 111
ASP A 112
 None
 1.35A 4ogrE-3vpzA:
undetectable		 4ogrE-3vpzA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 866
CYH A 919
ASN A1033
LEU A1035
ASP A1046
 LEV  A1201 (-3.5A)
LEV  A1201 (-4.1A)
GOL  A1210 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.77A 4ogrE-3wzdA:
22.7		 4ogrE-3wzdA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 841
ALA A 866
CYH A 919
LEU A1035
 B49  A2000 ( 4.6A)
B49  A2000 (-3.5A)
B49  A2000 (-4.2A)
B49  A2000 (-4.5A)
 0.33A 4ogrE-4agdA:
21.7		 4ogrE-4agdA:
26.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
CYH A  83
ASN A 131
LEU A 133
ASP A 144
 D15  A 500 (-3.4A)
D15  A 500 (-4.3A)
D15  A 500 (-3.0A)
D15  A 500 (-4.5A)
D15  A 500 (-3.7A)
 0.62A 4ogrE-4aguA:
31.2		 4ogrE-4aguA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 586
ASP A 640
ASN A 697
LEU A 699
ASP A 710
 LTI  A1839 (-3.3A)
None
None
LTI  A1839 (-4.2A)
None
 0.90A 4ogrE-4at3A:
22.5		 4ogrE-4at3A:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ALA A 104
ASP A 161
ASN A 206
LEU A 208
ASP A 219
 EDO  A1420 (-3.4A)
None
None
EDO  A1420 ( 4.8A)
None
 0.61A 4ogrE-4aw2A:
25.1		 4ogrE-4aw2A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  89
CYH A 142
ASN A 190
ASP A 203
 9ZP  A1333 (-3.5A)
9ZP  A1333 (-4.1A)
None
None
 0.22A 4ogrE-4b6lA:
28.9		 4ogrE-4b6lA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 GLY A  23
ALA A  43
ASN A 144
LEU A 146
ASP A 157
 STU  A1550 (-3.1A)
STU  A1550 (-3.1A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.80A 4ogrE-4cfhA:
27.7		 4ogrE-4cfhA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ALA A 684
ASP A 744
ASN A 787
LEU A 789
ASP A 800
 AGS  A1985 (-3.5A)
AGS  A1985 (-4.0A)
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.48A 4ogrE-4crsA:
25.9		 4ogrE-4crsA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 ALA A 588
ASP A 643
ASN A 688
LEU A 690
ASP A 701
 GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.6A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.53A 4ogrE-4e93A:
26.1		 4ogrE-4e93A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  16
ALA A  36
CYH A  89
ASN A 140
ASP A 157
 BX7  A 401 ( 3.7A)
BX7  A 401 (-3.4A)
BX7  A 401 (-4.1A)
None
BX7  A 401 ( 3.7A)
 0.53A 4ogrE-4eutA:
14.6		 4ogrE-4eutA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  16
ALA A  36
CYH A  89
ASN A 140
ASP A 157
 BX7  A 401 ( 3.8A)
BX7  A 401 (-3.4A)
BX7  A 401 (-4.1A)
None
BX7  A 401 (-3.6A)
 0.83A 4ogrE-4euuA:
19.5		 4ogrE-4euuA:
28.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  41
ASP A 104
ASN A 150
LEU A 152
ASP A 163
 0RS  A 900 ( 3.7A)
0RS  A 900 (-4.2A)
None
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
 0.82A 4ogrE-4ez5A:
28.0		 4ogrE-4ez5A:
37.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  20
ALA A  41
ASP A 104
LEU A 152
ASP A 163
 None
0RS  A 900 ( 3.7A)
0RS  A 900 (-4.2A)
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
 0.83A 4ogrE-4ez5A:
28.0		 4ogrE-4ez5A:
37.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  65
ALA A  88
ASN A 182
LEU A 184
ASP A 196
 ADP  A 601 ( 3.8A)
ADP  A 601 (-3.5A)
MG  A 602 ( 2.6A)
ADP  A 601 ( 4.9A)
MG  A 602 ( 3.1A)
 0.72A 4ogrE-4f99A:
17.7		 4ogrE-4f99A:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A1125
ALA A1148
ASP A1203
LEU A1256
ASP A1270
 0UV  A1501 (-3.6A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.90A 4ogrE-4fodA:
16.2		 4ogrE-4fodA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A1125
ASP A1203
ASN A1254
LEU A1256
ASP A1270
 0UV  A1501 (-3.6A)
0UV  A1501 ( 4.6A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.77A 4ogrE-4fodA:
16.2		 4ogrE-4fodA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  50
ASP A 107
ASN A 151
LEU A 153
ASP A 164
 STU  A 401 (-3.2A)
STU  A 401 (-3.3A)
STU  A 401 ( 4.8A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.51A 4ogrE-4fr4A:
11.9		 4ogrE-4fr4A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  30
ALA A  50
ASP A 107
LEU A 153
ASP A 164
 STU  A 401 (-3.3A)
STU  A 401 (-3.2A)
STU  A 401 (-3.3A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.90A 4ogrE-4fr4A:
11.9		 4ogrE-4fr4A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 GLY A 409
ALA A 429
ASN A 522
LEU A 524
ASP A 536
 0WB  A 701 ( 4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-4.1A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.70A 4ogrE-4g3fA:
25.4		 4ogrE-4g3fA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 829
ALA A 853
ASN A 954
LEU A 956
ASP A 967
 19S  A1201 (-3.7A)
19S  A1201 (-3.3A)
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.63A 4ogrE-4hviA:
25.2		 4ogrE-4hviA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 407
ALA A 427
ASN A 520
LEU A 522
ASP A 534
 T28  A 701 ( 3.6A)
T28  A 701 (-3.0A)
T28  A 701 ( 4.9A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.75A 4ogrE-4idtA:
25.4		 4ogrE-4idtA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 ALA A 279
ASP A 362
ASN A 414
LEU A 416
ASP A 427
 ANP  A 601 ( 3.9A)
ANP  A 601 (-4.1A)
MG  A 602 (-4.3A)
ANP  A 601 ( 4.9A)
MG  A 603 ( 2.0A)
 0.79A 4ogrE-4jrnA:
21.0		 4ogrE-4jrnA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A  43
ALA A  61
ASN A 161
LEU A 163
ASP A 175
 1UL  A 501 ( 4.1A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.68A 4ogrE-4l52A:
17.1		 4ogrE-4l52A:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ALA A  99
CYH A 149
ASN A 197
LEU A 199
ASP A 213
 STU  A 601 (-3.3A)
STU  A 601 (-4.2A)
None
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
 1.04A 4ogrE-4mvfA:
21.9		 4ogrE-4mvfA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA A 388
CYH A 435
ASN A 487
LEU A 489
ASP A 500
 None
 0.64A 4ogrE-4o1oA:
16.9		 4ogrE-4o1oA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  67
CYH A 126
ASN A 178
LEU A 180
ASP A 191
 SIN  A 401 ( 3.7A)
SIN  A 401 (-4.3A)
None
SIN  A 401 ( 4.5A)
None
 0.71A 4ogrE-4o38A:
21.7		 4ogrE-4o38A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA B 390
CYH B 437
ASN B 490
LEU B 492
ASP B 503
 ACP  B 801 (-3.2A)
ACP  B 801 (-4.5A)
MG  B 802 ( 2.5A)
ACP  B 801 (-4.5A)
MG  B 803 (-1.8A)
 0.35A 4ogrE-4oavB:
18.8		 4ogrE-4oavB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 904
ALA A 928
ASN A1028
LEU A1030
ASP A1041
 2TT  A1202 ( 4.2A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.5A)
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.66A 4ogrE-4oliA:
25.1		 4ogrE-4oliA:
18.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		5 ALA A  49
ASP A 110
ASN A 154
LEU A 156
ASP A 167
 ANP  A 402 (-3.3A)
ANP  A 402 (-3.4A)
MG  A 401 ( 2.7A)
ANP  A 402 (-4.6A)
ANP  A 402 ( 2.6A)
 0.74A 4ogrE-4qnyA:
30.9		 4ogrE-4qnyA:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 GLY A  25
ALA A  45
ASN A 146
LEU A 148
ASP A 159
 STU  A 601 (-3.5A)
STU  A 601 (-3.2A)
STU  A 601 (-4.2A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.73A 4ogrE-4rewA:
26.8		 4ogrE-4rewA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 642
CYH A 694
ASP A 698
ASN A 816
LEU A 818
 P30  A1001 (-3.4A)
None
None
None
P30  A1001 (-4.6A)
 0.70A 4ogrE-4rt7A:
17.1		 4ogrE-4rt7A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 CYH A 694
ASP A 698
ASN A 816
LEU A 818
ASP A 829
 None
None
None
P30  A1001 (-4.6A)
None
 0.90A 4ogrE-4rt7A:
17.1		 4ogrE-4rt7A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 617
ALA A 642
CYH A 694
ASP A 698
LEU A 818
 None
P30  A1001 (-3.4A)
None
None
P30  A1001 (-4.6A)
 0.82A 4ogrE-4rt7A:
17.1		 4ogrE-4rt7A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 151
ALA A 169
ASN A 273
LEU A 275
ASP A 294
 None
 0.86A 4ogrE-4uy9A:
21.8		 4ogrE-4uy9A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		5 GLY A 105
ALA A 125
ASN A 226
LEU A 228
ASP A 239
 ATP  A 501 (-3.5A)
ATP  A 501 (-3.4A)
ZN  A 502 ( 2.5A)
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.85A 4ogrE-4wb7A:
26.5		 4ogrE-4wb7A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  72
CYH A 129
ASN A 181
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
KSA  A 405 (-4.5A)
KSA  A 405 (-4.0A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.44A 4ogrE-4wsqA:
24.0		 4ogrE-4wsqA:
24.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 ASP A 109
ASN A 152
LEU A 154
ASP A 165
 None
None
42A  A 402 ( 4.9A)
None
 0.33A 4ogrE-4xrlA:
30.8		 4ogrE-4xrlA:
33.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 642
CYH A 694
ASP A 698
ASN A 816
LEU A 818
 P30  A1001 (-3.5A)
P30  A1001 (-4.2A)
None
None
P30  A1001 (-4.3A)
 0.80A 4ogrE-4xufA:
15.9		 4ogrE-4xufA:
29.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 617
ALA A 642
CYH A 694
ASP A 698
LEU A 818
 None
P30  A1001 (-3.5A)
P30  A1001 (-4.2A)
None
P30  A1001 (-4.3A)
 0.92A 4ogrE-4xufA:
15.9		 4ogrE-4xufA:
29.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
ASP A  86
ASN A 133
LEU A 135
ASP A 146
 None
 0.80A 4ogrE-4yc6A:
30.0		 4ogrE-4yc6A:
40.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 470
ALA A 488
ASN A 593
LEU A 595
ASP A 606
 4CV  A 801 ( 3.9A)
4CV  A 801 (-3.5A)
None
4CV  A 801 (-4.4A)
4CV  A 801 (-3.5A)
 0.66A 4ogrE-4yffA:
14.1		 4ogrE-4yffA:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  67
ASP A 143
ASN A 187
LEU A 189
ASP A 200
 4QZ  A 401 ( 4.1A)
None
None
None
None
 1.11A 4ogrE-4zslA:
29.7		 4ogrE-4zslA:
33.53