SIMILAR PATTERNS OF AMINO ACIDS FOR 4OGR_A_ADNA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  41
ALA A  54
ASP A 115
ASN A 158
ASP A 171
 ANP  A 400 (-4.1A)
ANP  A 400 (-3.3A)
ANP  A 400 (-3.4A)
MG  A 401 ( 2.9A)
MG  A 402 (-2.3A)
 0.61A 4ogrA-1cm8A:
25.9		 4ogrA-1cm8A:
32.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  10
VAL A  18
ALA A  31
ASP A  86
ASN A 131
LEU A 133
 None
 0.65A 4ogrA-1h4lA:
27.8		 4ogrA-1h4lA:
41.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ILE A 201
VAL A 209
ALA A 220
ASN A 319
LEU A 321
ASP A 332
 None
 0.65A 4ogrA-1k9aA:
25.5		 4ogrA-1k9aA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  73
VAL A  78
ALA A  91
ASN A 191
ASP A 207
 STU  A 401 (-3.6A)
STU  A 401 (-4.7A)
STU  A 401 (-3.4A)
STU  A 401 (-4.5A)
STU  A 401 (-3.6A)
 0.44A 4ogrA-1nxkA:
22.2		 4ogrA-1nxkA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 ILE A 211
VAL A 219
ALA A 230
ASN A 338
LEU A 340
 PY1  A 700 (-3.6A)
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
None
PY1  A 700 (-4.4A)
 0.56A 4ogrA-1py5A:
25.4		 4ogrA-1py5A:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 603
ALA A 621
ASP A 677
ASN A 797
LEU A 799
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
None
None
STI  A   3 (-4.4A)
 0.54A 4ogrA-1t46A:
22.9		 4ogrA-1t46A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 352
ALA A 367
ASN A 466
LEU A 468
ASP A 479
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-4.2A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.36A 4ogrA-1u59A:
25.7		 4ogrA-1u59A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
VAL A  42
ALA A  55
ASN A 156
LEU A 158
ASP A 169
 None
 0.49A 4ogrA-1u5qA:
28.7		 4ogrA-1u5qA:
29.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  26
ALA A  39
ASP A  97
ASN A 142
LEU A 144
 ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
ATP  A 381 ( 4.9A)
ATP  A 381 (-3.7A)
None
 0.60A 4ogrA-1ua2A:
31.3		 4ogrA-1ua2A:
38.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 ILE A  10
GLY A  13
VAL A  18
ALA A  30
ASN A 130
LEU A 132
 None
 0.72A 4ogrA-1v0bA:
30.2		 4ogrA-1v0bA:
39.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 VAL A  18
ALA A  30
ASP A  85
ASN A 130
LEU A 132
 None
 0.43A 4ogrA-1v0bA:
30.2		 4ogrA-1v0bA:
39.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  18
VAL A  23
ALA A  36
ASN A 135
ASP A 148
 HYM  A 400 ( 3.7A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
HYM  A 400 (-3.9A)
 0.59A 4ogrA-1zltA:
28.3		 4ogrA-1zltA:
29.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  23
ALA A  36
ASN A 135
LEU A 137
ASP A 148
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.55A 4ogrA-1zltA:
28.3		 4ogrA-1zltA:
29.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL X  25
ALA X  37
ASN X 135
LEU X 137
ASP X 148
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.9A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.48A 4ogrA-2dq7X:
26.5		 4ogrA-2dq7X:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
VAL A  42
ALA A  55
ASN A 156
LEU A 158
ASP A 169
 STU  A 400 (-4.2A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 (-4.4A)
STU  A 400 ( 4.6A)
STU  A 400 (-3.6A)
 0.42A 4ogrA-2gcdA:
28.6		 4ogrA-2gcdA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 281
ALA A 293
ASN A 391
LEU A 393
ASP A 404
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.59A 4ogrA-2h8hA:
23.3		 4ogrA-2h8hA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ILE A 635
GLY A 638
VAL A 643
ALA A 659
LEU A 761
 ADP  A 400 (-4.9A)
ADP  A 400 ( 4.0A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.7A)
 0.59A 4ogrA-2henA:
17.1		 4ogrA-2henA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  46
ALA A  59
ASP A 124
ASN A 168
ASP A 182
 HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 4.9A)
HB1  A1289 (-4.2A)
 0.60A 4ogrA-2iwiA:
16.9		 4ogrA-2iwiA:
25.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  13
ALA A  31
ASP A  86
ASN A 132
LEU A 134
ASP A 145
 None
 0.68A 4ogrA-2jgzA:
36.9		 4ogrA-2jgzA:
42.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  10
GLY A  13
VAL A  18
ALA A  31
ASN A 132
LEU A 134
ASP A 145
 None
 0.65A 4ogrA-2jgzA:
36.9		 4ogrA-2jgzA:
42.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 ILE A 428
GLY A 431
VAL A 436
ALA A 452
LEU A 553
 BII  A1687 (-3.8A)
BII  A1687 ( 4.1A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-4.2A)
 0.30A 4ogrA-2jkmA:
23.7		 4ogrA-2jkmA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 199
VAL A 204
ALA A 215
ASN A 326
LEU A 328
ASP A 339
 None
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.4A)
None
 0.77A 4ogrA-2qluA:
26.4		 4ogrA-2qluA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 732
ALA A 749
ASN A 848
LEU A 850
ASP A 861
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
None
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.43A 4ogrA-2r4bA:
23.0		 4ogrA-2r4bA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  77
VAL A  85
ALA A  98
ASN A 200
LEU A 202
 BI8  A1417 (-4.1A)
BI8  A1417 ( 4.7A)
BI8  A1417 ( 3.8A)
BI8  A1417 (-3.6A)
BI8  A1417 (-4.8A)
 0.58A 4ogrA-2vd5A:
25.7		 4ogrA-2vd5A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		6 ILE A 490
VAL A 498
ALA A 509
ASP A 611
ASN A 654
LEU A 656
 None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
5ID  A1800 (-3.6A)
None
5ID  A1800 (-4.5A)
 0.58A 4ogrA-2vuwA:
16.9		 4ogrA-2vuwA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		6 VAL A 498
ALA A 509
ASP A 611
ASN A 654
LEU A 656
ASP A 687
 5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
5ID  A1800 (-3.6A)
None
5ID  A1800 (-4.5A)
IOD  A1799 (-4.0A)
 0.56A 4ogrA-2vuwA:
16.9		 4ogrA-2vuwA:
23.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY B  15
VAL B  20
ALA B  33
ASP B  99
ASN B 145
LEU B 147
 None
 1.05A 4ogrA-2w9fB:
24.5		 4ogrA-2w9fB:
36.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  29
VAL A  34
ALA A  47
ASN A 145
LEU A 147
ASP A 158
 J60  A1294 ( 4.5A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.61A 4ogrA-2xikA:
30.8		 4ogrA-2xikA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 305
VAL A 313
ALA A 326
ASN A 431
ASP A 463
 770  A 901 (-3.8A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-3.8A)
 0.58A 4ogrA-2z2wA:
26.6		 4ogrA-2z2wA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  71
VAL A  76
ALA A  92
ASP A 148
ASN A 192
LEU A 194
 STU  A   1 ( 4.1A)
None
STU  A   1 (-3.3A)
STU  A   1 (-3.8A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
 0.95A 4ogrA-2z7rA:
24.3		 4ogrA-2z7rA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  76
ALA A  92
ASP A 148
ASN A 192
LEU A 194
ASP A 205
 None
STU  A   1 (-3.3A)
STU  A   1 (-3.8A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.71A 4ogrA-2z7rA:
24.3		 4ogrA-2z7rA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 201
VAL A 209
ALA A 220
ASN A 319
LEU A 321
ASP A 332
 None
 0.65A 4ogrA-3d7uA:
19.0		 4ogrA-3d7uA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 VAL A  23
ALA A  36
ASN A 171
LEU A 173
ASP A 185
 None
DRK  A 384 (-3.5A)
DRK  A 384 ( 4.6A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 4.7A)
 0.59A 4ogrA-3eb0A:
30.0		 4ogrA-3eb0A:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 GLY A  85
VAL A  90
ALA A 103
ASN A 204
LEU A 206
ASP A 220
 GOL  A 542 ( 4.8A)
None
J60  A 540 (-3.6A)
GOL  A 542 ( 4.8A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.75A 4ogrA-3hztA:
20.6		 4ogrA-3hztA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 VAL A 649
ALA A 665
ASN A 765
LEU A 767
ASP A 778
 None
 0.54A 4ogrA-3kulA:
25.5		 4ogrA-3kulA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 GLY A 213
VAL A 218
ALA A 229
ASN A 337
LEU A 339
ASP A 350
 LDN  A   1 ( 4.4A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-4.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.61A 4ogrA-3mdyA:
26.9		 4ogrA-3mdyA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ILE A 210
GLY A 213
VAL A 218
ALA A 229
ASN A 337
LEU A 339
 LDN  A   1 (-4.1A)
LDN  A   1 ( 4.4A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-4.3A)
LDN  A   1 (-4.5A)
 0.59A 4ogrA-3mdyA:
26.9		 4ogrA-3mdyA:
27.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  25
ALA A  46
ASP A 109
ASN A 154
LEU A 156
ASP A 167
 None
 0.51A 4ogrA-3mi9A:
46.0		 4ogrA-3mi9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  25
VAL A  33
ALA A  46
ASP A 109
ASN A 154
LEU A 156
 None
 0.63A 4ogrA-3mi9A:
46.0		 4ogrA-3mi9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 179
ALA A 192
ASP A 246
ASN A 291
LEU A 293
 FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 ( 4.3A)
FEF  A 668 (-3.9A)
FEF  A 668 (-4.2A)
 0.53A 4ogrA-3mtlA:
30.4		 4ogrA-3mtlA:
38.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  57
ALA A  70
ASN A 171
LEU A 173
ASP A 184
 XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.6A)
None
 0.60A 4ogrA-3mvjA:
26.9		 4ogrA-3mvjA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		5 ILE A  34
VAL A  42
ALA A  55
ASP A 115
LEU A 161
 GOL  A 434 ( 4.5A)
None
GOL  A 434 ( 4.1A)
GOL  A 434 (-3.6A)
GOL  A 434 (-4.2A)
 0.56A 4ogrA-3n9xA:
29.5		 4ogrA-3n9xA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ILE A  36
VAL A  44
ALA A  57
ASP A 117
LEU A 163
 ANP  A 430 (-4.4A)
ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 (-3.3A)
ANP  A 430 (-4.4A)
 0.55A 4ogrA-3nieA:
29.8		 4ogrA-3nieA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 VAL A 200
ALA A 213
ASP A 270
ASN A 316
LEU A 318
ASP A 329
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-3.6A)
AMP  A 577 (-4.2A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.66A 4ogrA-3nyoA:
28.3		 4ogrA-3nyoA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 729
VAL A 734
ALA A 751
LEU A 852
ASP A 863
 03Q  A   1 (-3.3A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.63A 4ogrA-3pp0A:
25.7		 4ogrA-3pp0A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 734
ALA A 751
ASN A 850
LEU A 852
ASP A 863
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.38A 4ogrA-3pp0A:
25.7		 4ogrA-3pp0A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ILE A 557
VAL A 565
ALA A 576
ASN A 681
LEU A 683
ASP A 694
 STU  A   1 (-4.1A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.6A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.71A 4ogrA-3ppzA:
27.6		 4ogrA-3ppzA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 201
VAL A 206
ALA A 217
ASN A 327
LEU A 329
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
 0.61A 4ogrA-3q4tA:
26.0		 4ogrA-3q4tA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 206
ALA A 217
ASN A 327
LEU A 329
ASP A 340
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
None
 0.41A 4ogrA-3q4tA:
26.0		 4ogrA-3q4tA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 VAL A  71
ALA A  84
ASN A 195
LEU A 197
ASP A 211
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
CA  A 528 ( 3.0A)
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.63A 4ogrA-3q5iA:
25.1		 4ogrA-3q5iA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  82
VAL A  90
ALA A 103
ASN A 205
LEU A 207
ASP A 218
 None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
None
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.51A 4ogrA-3qfvA:
25.4		 4ogrA-3qfvA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  82
VAL A  90
ASP A 160
ASN A 205
LEU A 207
ASP A 218
 None
NM7  A 416 (-3.7A)
None
None
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
 0.59A 4ogrA-3qfvA:
25.4		 4ogrA-3qfvA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  53
VAL A  58
ALA A  71
ASN A 171
LEU A 173
ASP A 187
 I85  A 350 (-3.1A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
I85  A 350 (-4.4A)
None
I85  A 350 (-3.3A)
 0.66A 4ogrA-3sheA:
21.0		 4ogrA-3sheA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 VAL A 369
ALA A 382
ASP A 440
ASN A 484
LEU A 486
 07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.9A)
None
07U  A   1 (-4.3A)
 0.60A 4ogrA-3txoA:
16.9		 4ogrA-3txoA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 VAL A 369
ASP A 440
ASN A 484
LEU A 486
ASP A 497
 07U  A   1 (-4.8A)
07U  A   1 (-3.9A)
None
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.60A 4ogrA-3txoA:
16.9		 4ogrA-3txoA:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  10
VAL A  18
ALA A  31
ASN A 131
LEU A 133
 D15  A 500 (-4.2A)
D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 (-3.0A)
D15  A 500 (-4.5A)
 0.60A 4ogrA-4aguA:
31.8		 4ogrA-4aguA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ILE A  83
VAL A  91
ALA A 104
ASN A 206
LEU A 208
ASP A 219
 None
None
EDO  A1420 (-3.4A)
None
EDO  A1420 ( 4.8A)
None
 0.51A 4ogrA-4aw2A:
25.2		 4ogrA-4aw2A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A  97
GLY A 100
VAL A 105
ALA A 121
LEU A 223
 30K  A1365 (-4.5A)
30K  A1365 ( 4.4A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-4.5A)
 0.44A 4ogrA-4aw5A:
16.1		 4ogrA-4aw5A:
27.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  18
ALA A  31
ASN A 131
LEU A 133
ASP A 144
 None
TC0  A 500 (-3.5A)
None
TC0  A 500 (-4.3A)
TC0  A 500 (-4.8A)
 0.57A 4ogrA-4bbmA:
27.8		 4ogrA-4bbmA:
34.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 GLY A  25
VAL A  30
ALA A  43
ASN A 144
LEU A 146
ASP A 157
 STU  A1550 (-3.8A)
None
STU  A1550 (-3.1A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.77A 4ogrA-4cfhA:
28.7		 4ogrA-4cfhA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 VAL A 671
ALA A 684
ASP A 744
ASN A 787
LEU A 789
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.0A)
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
 0.55A 4ogrA-4crsA:
26.5		 4ogrA-4crsA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 ALA A 588
ASP A 643
ASN A 688
LEU A 690
ASP A 701
 GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.6A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.54A 4ogrA-4e93A:
27.3		 4ogrA-4e93A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 ILE A 567
GLY A 570
VAL A 575
ALA A 588
ASP A 643
ASN A 688
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.6A)
GUI  A 901 (-4.3A)
 0.74A 4ogrA-4e93A:
27.3		 4ogrA-4e93A:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  64
VAL A  72
ALA A  88
ASN A 182
LEU A 184
ASP A 196
 None
ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
MG  A 602 ( 2.6A)
ADP  A 601 ( 4.9A)
MG  A 602 ( 3.1A)
 0.53A 4ogrA-4f99A:
22.1		 4ogrA-4f99A:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  29
VAL A  37
ALA A  50
ASP A 107
ASN A 151
LEU A 153
ASP A 164
 STU  A 401 (-4.1A)
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
STU  A 401 (-3.3A)
STU  A 401 ( 4.8A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.69A 4ogrA-4fr4A:
27.1		 4ogrA-4fr4A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 GLY A 411
VAL A 416
ALA A 429
LEU A 524
ASP A 536
 0WB  A 701 (-3.6A)
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.62A 4ogrA-4g3fA:
26.5		 4ogrA-4g3fA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 VAL A 416
ALA A 429
ASN A 522
LEU A 524
ASP A 536
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-4.1A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.49A 4ogrA-4g3fA:
26.5		 4ogrA-4g3fA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 409
VAL A 414
ALA A 427
ASN A 520
LEU A 522
ASP A 534
 T28  A 701 ( 3.0A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 4.9A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.73A 4ogrA-4idtA:
26.4		 4ogrA-4idtA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ILE B 371
ALA B 390
ASN B 490
LEU B 492
ASP B 503
 ACP  B 801 (-4.2A)
ACP  B 801 (-3.2A)
MG  B 802 ( 2.5A)
ACP  B 801 (-4.5A)
MG  B 803 (-1.8A)
 0.55A 4ogrA-4oavB:
19.1		 4ogrA-4oavB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ILE A 619
GLY A 622
VAL A 627
ALA A 644
LEU A 746
 None
 0.43A 4ogrA-4p2kA:
25.3		 4ogrA-4p2kA:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		5 ILE A  27
VAL A  35
ALA A  49
ASP A 110
LEU A 156
 ANP  A 402 (-4.6A)
ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-3.4A)
ANP  A 402 (-4.6A)
 0.61A 4ogrA-4qnyA:
31.7		 4ogrA-4qnyA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		5 VAL A  35
ALA A  49
ASP A 110
ASN A 154
LEU A 156
 ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-3.4A)
MG  A 401 ( 2.7A)
ANP  A 402 (-4.6A)
 0.60A 4ogrA-4qnyA:
31.7		 4ogrA-4qnyA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  48
VAL A  56
ALA A  69
ASP A 128
ASN A 171
LEU A 173
 38Z  A 418 ( 4.4A)
None
38Z  A 418 (-3.4A)
EDO  A 413 (-2.9A)
None
38Z  A 418 (-4.4A)
 0.64A 4ogrA-4qtbA:
31.1		 4ogrA-4qtbA:
31.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 GLY A  27
VAL A  32
ALA A  45
ASN A 146
LEU A 148
ASP A 159
 STU  A 601 (-3.4A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.2A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.71A 4ogrA-4rewA:
27.8		 4ogrA-4rewA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 150
GLY A 153
VAL A 158
ALA A 169
ASN A 273
LEU A 275
ASP A 294
 None
 0.62A 4ogrA-4uy9A:
22.7		 4ogrA-4uy9A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		5 VAL A 112
ALA A 125
ASN A 226
LEU A 228
ASP A 239
 ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ZN  A 502 ( 2.5A)
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.61A 4ogrA-4wb7A:
27.3		 4ogrA-4wb7A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 147
VAL A 152
ALA A 165
ASN A 258
ASP A 270
 499  A 401 (-3.3A)
499  A 401 (-4.6A)
499  A 401 (-3.2A)
499  A 401 ( 4.8A)
499  A 401 (-3.7A)
 0.60A 4ogrA-4y85A:
26.9		 4ogrA-4y85A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 469
VAL A 477
ALA A 488
ASN A 593
LEU A 595
ASP A 606
 4CV  A 801 (-4.3A)
None
4CV  A 801 (-3.5A)
None
4CV  A 801 (-4.4A)
4CV  A 801 (-3.5A)
 0.44A 4ogrA-4yffA:
23.3		 4ogrA-4yffA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 165
VAL A 173
ALA A 186
ASN A 292
LEU A 294
 4E1  A 505 ( 4.6A)
4E1  A 505 (-4.5A)
4E1  A 505 (-3.5A)
None
None
 0.54A 4ogrA-4yljA:
29.9		 4ogrA-4yljA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 165
VAL A 173
ASN A 292
LEU A 294
ASP A 307
 4E1  A 505 ( 4.6A)
4E1  A 505 (-4.5A)
None
None
4E1  A 505 (-3.6A)
 0.60A 4ogrA-4yljA:
29.9		 4ogrA-4yljA:
27.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  22
VAL A  30
ALA A  44
ASN A 143
LEU A 145
 51W  A 401 (-3.9A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 4.6A)
51W  A 401 (-4.5A)
 0.60A 4ogrA-5ci7A:
27.2		 4ogrA-5ci7A:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  34
VAL A  39
ALA A  52
ASN A 158
LEU A 160
ASP A 171
 GLY  A  34 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
ASN  A 158 ( 0.6A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
 0.58A 4ogrA-5d7aA:
26.3		 4ogrA-5d7aA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 906
VAL A 911
ALA A 928
ASN A1028
LEU A1030
ASP A1041
 5U3  A1200 ( 4.4A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.7A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.58A 4ogrA-5f1zA:
26.8		 4ogrA-5f1zA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 463
VAL A 471
ALA A 481
ASN A 581
ASP A 594
 5XJ  A 801 ( 4.7A)
5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
None
None
 0.52A 4ogrA-5fd2A:
23.9		 4ogrA-5fd2A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  65
ALA A  77
ASN A 185
LEU A 187
ASP A 198
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-4.1A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.49A 4ogrA-5i3oA:
24.4		 4ogrA-5i3oA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 GLY A  25
VAL A  30
ALA A  43
ASN A 144
LEU A 146
ASP A 157
 STU  A 601 (-3.7A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.62A 4ogrA-5isoA:
28.0		 4ogrA-5isoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  22
GLY A  25
VAL A  30
ALA A  43
ASN A 141
LEU A 143
ASP A 154
 6G2  A 901 (-3.8A)
6G2  A 901 (-3.6A)
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.48A 4ogrA-5j5tA:
25.9		 4ogrA-5j5tA:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  41
VAL A  49
ALA A  60
ASN A 161
LEU A 163
 STU  A 901 (-4.3A)
None
STU  A 901 (-3.3A)
STU  A 901 ( 4.8A)
STU  A 901 (-4.5A)
 0.58A 4ogrA-5lohA:
18.1		 4ogrA-5lohA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 VAL A 897
ALA A 909
ASN A1014
LEU A1016
ASP A1027
 ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.6A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
 0.44A 4ogrA-5lpyA:
24.9		 4ogrA-5lpyA:
26.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 155
VAL A 163
ALA A 176
ASN A 280
LEU A 282
ASP A 295
 7A7  A 501 ( 4.3A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.8A)
7A7  A 501 (-4.9A)
7A7  A 501 (-3.2A)
 0.62A 4ogrA-5lxdA:
29.4		 4ogrA-5lxdA:
31.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 5 VAL A  52
ALA A  65
ASP A 128
ASN A 172
ASP A 186
 7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
7LK  A 401 ( 3.9A)
None
None
 0.63A 4ogrA-5turA:
27.0		 4ogrA-5turA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uu1 SERINE/THREONINE-PRO
TEIN KINASE VRK2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  39
ASP A 127
ASN A 171
LEU A 173
ASP A 186
 None
None
7DZ  A 401 ( 4.7A)
None
7DZ  A 401 ( 4.8A)
 0.53A 4ogrA-5uu1A:
21.7		 4ogrA-5uu1A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 6 GLY A 689
VAL A 694
ALA A 707
ASN A 808
LEU A 810
ASP A 822
 9E1  A1001 (-2.9A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.58A 4ogrA-5vilA:
27.9		 4ogrA-5vilA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 5 ILE A 215
VAL A 223
ALA A 236
ASN A 340
LEU A 342
 None
HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
None
None
 0.55A 4ogrA-5y86A:
29.8		 4ogrA-5y86A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 5 VAL A 223
ALA A 236
ASP A 294
ASN A 340
LEU A 342
 HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
None
None
None
 0.63A 4ogrA-5y86A:
29.8		 4ogrA-5y86A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 7 ILE A 733
VAL A 741
ALA A 754
ASP A 819
ASN A 864
LEU A 866
ASP A 877
 CJM  A1102 (-3.4A)
None
CJM  A1102 (-3.1A)
CJM  A1102 (-4.1A)
MG  A1101 ( 4.4A)
CJM  A1102 (-4.4A)
MG  A1101 (-2.5A)
 0.41A 4ogrA-6b3eA:
40.3		 4ogrA-6b3eA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 5 ILE A 531
VAL A 539
ALA A 551
ASP A 608
LEU A 654
 CQ7  A 801 (-3.6A)
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-4.7A)
CQ7  A 801 (-4.5A)
 0.63A 4ogrA-6b4wA:
23.2		 4ogrA-6b4wA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 6 ILE A  66
VAL A  74
ALA A  87
ASN A 187
LEU A 189
ASP A 200
 None
 0.86A 4ogrA-6c9dA:
27.2		 4ogrA-6c9dA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 6 GLY A 174
VAL A 179
ALA A 192
ASN A 317
LEU A 319
ASP A 330
 F6J  A 501 (-3.5A)
F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 ( 4.7A)
F6J  A 501 (-4.5A)
F6J  A 501 (-3.8A)
 0.77A 4ogrA-6cmjA:
27.5		 4ogrA-6cmjA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 6 ILE A 171
GLY A 174
VAL A 179
ALA A 192
ASN A 317
LEU A 319
 F6J  A 501 (-4.3A)
F6J  A 501 (-3.5A)
F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 ( 4.7A)
F6J  A 501 (-4.5A)
 0.78A 4ogrA-6cmjA:
27.5		 4ogrA-6cmjA:
14.92