SIMILAR PATTERNS OF AMINO ACIDS FOR 4ODO_C_FK5C204_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b74 GLUTAMATE RACEMASE

(Aquifex
pyrophilus) 		PF01177
(Asp_Glu_race) 		5 ASP A   7
LEU A 234
ILE A 235
LEU A 231
PHE A 224
 None
 1.06A 4odoC-1b74A:
undetectable		 4odoC-1b74A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A 131
ASP A 142
ILE A 159
TYR A 185
PHE A 202
 None
 0.64A 4odoC-1fd9A:
9.7		 4odoC-1fd9A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		5 TYR A  26
ASP A  37
ILE A  56
TYR A  82
PHE A  99
 None
 0.51A 4odoC-1fkkA:
11.7		 4odoC-1fkkA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6u INTERNALIN H

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		5 LEU A 149
LEU A 103
LEU A 116
LEU A 113
LEU A 160
 None
 1.08A 4odoC-1h6uA:
undetectable		 4odoC-1h6uA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq4 50S RIBOSOMAL
PROTEIN L5

(Geobacillus
stearothermophilus) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		5 TYR A 128
LEU A 130
LEU A 103
ILE A 104
LEU A 100
 None
 0.95A 4odoC-1iq4A:
undetectable		 4odoC-1iq4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		5 TYR A  92
ASP A 103
ILE A 120
TYR A 146
PHE A 163
 None
 0.70A 4odoC-1jvwA:
8.4		 4odoC-1jvwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1a FKBP52

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
ILE A  87
TYR A 113
PHE A 130
 None
 0.67A 4odoC-1n1aA:
11.0		 4odoC-1n1aA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pbk FKBP25

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A 135
ASP A 146
LEU A 162
ILE A 172
TYR A 198
PHE A 216
 RAP  A 225 (-3.9A)
RAP  A 225 (-3.0A)
RAP  A 225 (-4.8A)
RAP  A 225 (-3.9A)
RAP  A 225 (-4.6A)
None
 0.51A 4odoC-1pbkA:
11.2		 4odoC-1pbkA:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 LEU A 237
LEU A 230
LEU A 330
ILE A 333
LEU A 334
LEU A 210
 None
 1.38A 4odoC-1poxA:
undetectable		 4odoC-1poxA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A 146
ASP A 157
ILE A 174
TYR A 200
PHE A 216
 None
 0.68A 4odoC-1q6hA:
9.4		 4odoC-1q6hA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A 146
LEU A 166
ILE A 174
TYR A 200
PHE A 216
 None
 0.80A 4odoC-1q6hA:
9.4		 4odoC-1q6hA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9h FK506 BINDING
PROTEIN FAMILY

(Caenorhabditis
elegans) 		PF00254
(FKBP_C) 		5 TYR A  40
ASP A  51
ILE A  70
TYR A  96
PHE A 113
 None
 0.71A 4odoC-1r9hA:
11.3		 4odoC-1r9hA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE

(Mycobacterium
tuberculosis) 		PF01451
(LMWPc) 		5 LEU A 149
LEU A  34
LEU A  29
LEU A  85
PHE A  25
 None
 1.03A 4odoC-1u2qA:
undetectable		 4odoC-1u2qA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Arabidopsis
thaliana) 		PF00254
(FKBP_C) 		5 TYR A  37
ASP A  48
ILE A  67
TYR A  99
PHE A 121
 None
 0.58A 4odoC-1u79A:
10.6		 4odoC-1u79A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Arabidopsis
thaliana) 		PF00254
(FKBP_C) 		5 TYR A  37
LEU A  57
ILE A  67
TYR A  99
PHE A 121
 None
 0.48A 4odoC-1u79A:
10.6		 4odoC-1u79A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		5 TYR A  32
LEU A  35
LEU A 114
LEU A 208
LEU A 259
 None
None
NH3  A 403 ( 4.6A)
NH3  A 401 (-4.5A)
BOG  A 400 (-4.3A)
 0.88A 4odoC-1u7gA:
undetectable		 4odoC-1u7gA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ul1 FLAP ENDONUCLEASE-1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 LEU X 226
LEU X 209
ILE X 212
LEU X 213
LEU X   9
 None
 0.90A 4odoC-1ul1X:
undetectable		 4odoC-1ul1X:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeu INTERNALIN C

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		6 LEU A 147
LEU A 102
LEU A 115
ILE A 137
LEU A 112
LEU A 158
 None
 1.41A 4odoC-1xeuA:
undetectable		 4odoC-1xeuA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yat FK506 BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		5 TYR A  26
ASP A  37
ILE A  56
TYR A  82
PHE A  99
 FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.3A)
FK5  A 108 ( 3.7A)
FK5  A 108 ( 4.7A)
None
 0.39A 4odoC-1yatA:
11.5		 4odoC-1yatA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		PF12937
(F-box-like) 		5 ASP B2187
LEU B2216
LEU B2198
ILE B2201
LEU B2202
 None
 0.95A 4odoC-2assB:
undetectable		 4odoC-2assB:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 300
LEU A 318
ILE A 319
LEU A 315
LEU A 409
 ADP  A1482 (-3.6A)
None
None
ADP  A1482 (-4.9A)
None
 1.07A 4odoC-2cgjA:
undetectable		 4odoC-2cgjA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g18 PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE

(Anabaena sp.) 		PF05996
(Fe_bilin_red) 		5 LEU A 240
LEU A  72
LEU A  84
ILE A  83
LEU A 223
 None
 1.04A 4odoC-2g18A:
undetectable		 4odoC-2g18A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9f PEPTIDE N-GLYCANASE

(Mus musculus) 		PF04721
(PAW) 		5 LEU A 642
ILE A 548
LEU A 537
LEU A 611
PHE A 630
 None
 1.02A 4odoC-2g9fA:
undetectable		 4odoC-2g9fA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		5 LEU A 271
ILE A 108
LEU A 105
LEU A 286
PHE A 144
 None
 1.07A 4odoC-2h98A:
undetectable		 4odoC-2h98A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 LEU A 696
LEU A 542
ILE A 538
LEU A 541
LEU A 653
 None
 1.00A 4odoC-2iujA:
2.2		 4odoC-2iujA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 LEU A 256
LEU A 239
ILE A 236
LEU A 235
LEU A 213
 None
 0.85A 4odoC-2jgdA:
undetectable		 4odoC-2jgdA:
11.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2kfw FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD

(Escherichia
coli) 		PF00254
(FKBP_C) 		5 LEU A  32
LEU A  41
ILE A  42
LEU A  45
TYR A  68
 None
 0.98A 4odoC-2kfwA:
11.9		 4odoC-2kfwA:
41.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  56
ASP A  67
ILE A  86
TYR A 112
PHE A 129
 PEG  A 201 (-4.4A)
None
PEG  A 201 (-3.8A)
None
None
 0.50A 4odoC-2pbcA:
12.3		 4odoC-2pbcA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 TYR A 127
LEU A 163
LEU A 126
LEU A 109
LEU A 145
 None
 1.03A 4odoC-2qbyA:
undetectable		 4odoC-2qbyA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE

(Escherichia
coli) 		PF01266
(DAO) 		5 LEU A 363
LEU A 368
LEU A 331
ILE A 332
LEU A 330
 None
 1.04A 4odoC-2uzzA:
undetectable		 4odoC-2uzzA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		5 LEU A 512
LEU A 525
ILE A 522
LEU A 521
LEU A 576
 None
 1.02A 4odoC-2v5dA:
undetectable		 4odoC-2v5dA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE

(Plasmodium
falciparum) 		PF00254
(FKBP_C) 		5 TYR A  44
ASP A  56
ILE A  75
TYR A 101
PHE A 118
 FK5  A 501 (-4.1A)
FK5  A 501 (-3.4A)
FK5  A 501 (-4.3A)
FK5  A 501 (-4.7A)
FK5  A 501 (-4.8A)
 0.36A 4odoC-2vn1A:
11.5		 4odoC-2vn1A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 ASP A 480
LEU A 321
LEU A 470
ILE A 476
LEU A 491
 None
 0.83A 4odoC-2x3kA:
undetectable		 4odoC-2x3kA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		5 TYR A  33
ASP A  44
ILE A  63
TYR A  89
PHE A 106
 None
 0.75A 4odoC-2y78A:
10.9		 4odoC-2y78A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		5 LEU A 363
LEU A 443
LEU A 397
LEU A 433
PHE A 376
 None
 1.03A 4odoC-2ykyA:
undetectable		 4odoC-2ykyA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywn PEROXIREDOXIN-LIKE
PROTEIN

(Sulfurisphaera
tokodaii) 		PF00578
(AhpC-TSA) 		5 ASP A  10
LEU A  26
LEU A  66
ILE A  68
LEU A  33
 None
 1.06A 4odoC-2ywnA:
undetectable		 4odoC-2ywnA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b33 SENSOR PROTEIN

(Vibrio
parahaemolyticus) 		PF00989
(PAS) 		5 LEU A  36
ILE A  53
LEU A  52
LEU A  89
PHE A  37
 None
 1.00A 4odoC-3b33A:
undetectable		 4odoC-3b33A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1l PUTATIVE NADP
OXIDOREDUCTASE
BF3122

(Bacteroides
fragilis) 		PF03807
(F420_oxidored)
PF10728
(DUF2520) 		5 LEU A 149
LEU A 156
LEU A  22
ILE A  70
LEU A  94
 None
 1.03A 4odoC-3d1lA:
undetectable		 4odoC-3d1lA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		5 LEU A 271
ILE A 108
LEU A 105
LEU A 286
PHE A 144
 None
 1.06A 4odoC-3glbA:
undetectable		 4odoC-3glbA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 2

(Thermus
thermophilus) 		PF01257
(2Fe-2S_thioredx) 		5 TYR 2  78
LEU 2 116
LEU 2 163
LEU 2 153
PHE 2 117
 None
 1.06A 4odoC-3i9v2:
undetectable		 4odoC-3i9v2:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE

(Streptococcus
mutans) 		PF01048
(PNP_UDP_1) 		5 LEU A  26
LEU A 266
ILE A 265
LEU A 269
LEU A 177
 None
 1.01A 4odoC-3la8A:
undetectable		 4odoC-3la8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 LEU A 778
LEU A 822
LEU A 755
LEU A 752
LEU A 914
 None
 0.98A 4odoC-3lj0A:
undetectable		 4odoC-3lj0A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
ILE A  87
TYR A 113
PHE A 130
 None
 0.76A 4odoC-3o5dA:
10.1		 4odoC-3o5dA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
ILE A  87
TYR A 113
PHE A 130
 None
 0.67A 4odoC-3o5eA:
10.9		 4odoC-3o5eA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		5 TYR A  43
ASP A  55
ILE A  74
TYR A 100
PHE A 117
 None
 0.81A 4odoC-3pa7A:
10.8		 4odoC-3pa7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		5 LEU A 298
LEU A 291
LEU A 195
ILE A 191
PHE A  49
 None
 1.02A 4odoC-3q1oA:
undetectable		 4odoC-3q1oA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2

(Rattus
norvegicus) 		PF01070
(FMN_dh) 		5 LEU A 327
LEU A 320
LEU A 300
ILE A 298
LEU A 291
 None
 1.08A 4odoC-3sgzA:
undetectable		 4odoC-3sgzA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqn CONSERVED DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF05043
(Mga) 		5 LEU A  88
LEU A  25
LEU A  21
TYR A   2
LEU A   5
 None
 1.06A 4odoC-3sqnA:
undetectable		 4odoC-3sqnA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 LEU A 387
LEU A 414
ILE A 415
LEU A 411
PHE A 532
 None
 1.07A 4odoC-3to3A:
undetectable		 4odoC-3to3A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqz DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Coxiella
burnetii) 		PF00692
(dUTPase) 		5 LEU A  33
ASP A  32
LEU A  20
LEU A   7
ILE A  57
 None
 1.07A 4odoC-3tqzA:
undetectable		 4odoC-3tqzA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		5 TYR A 313
ASP A 324
ILE A 342
TYR A 368
PHE A 384
 None
 0.94A 4odoC-4bf8A:
10.7		 4odoC-4bf8A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A

(Homo sapiens) 		PF01201
(Ribosomal_S8e) 		5 LEU i 586
ILE i 545
LEU i 594
LEU i 608
PHE i 522
 None
 1.06A 4odoC-4d61i:
2.7		 4odoC-4d61i:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dt4 FKBP-TYPE 16 KDA
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Escherichia
coli) 		PF00254
(FKBP_C) 		5 LEU A  17
LEU A  44
LEU A  48
LEU A 129
PHE A 136
 None
 0.95A 4odoC-4dt4A:
12.1		 4odoC-4dt4A:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz3 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		5 TYR A  33
ASP A  44
ILE A  63
TYR A  89
PHE A 106
 FK5  A 201 ( 3.9A)
FK5  A 201 (-3.5A)
FK5  A 201 (-3.8A)
FK5  A 201 (-4.7A)
FK5  A 201 (-4.8A)
 0.35A 4odoC-4dz3A:
11.3		 4odoC-4dz3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecl SERINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 LEU A 335
ILE A 308
LEU A 292
LEU A 280
PHE A 288
 None
 1.03A 4odoC-4eclA:
undetectable		 4odoC-4eclA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 172
LEU A 464
LEU A 323
LEU A 186
PHE A 168
 None
 0.87A 4odoC-4fdhA:
undetectable		 4odoC-4fdhA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fho INTERNALIN C2

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		5 LEU A 149
LEU A 103
LEU A 116
LEU A 113
LEU A 160
 None
 1.08A 4odoC-4fhoA:
undetectable		 4odoC-4fhoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		5 LEU A 203
LEU A 385
ILE A 427
LEU A 430
LEU A 397
 LEU  A 203 ( 0.5A)
LEU  A 385 ( 0.6A)
ILE  A 427 ( 0.7A)
LEU  A 430 ( 0.6A)
LEU  A 397 ( 0.5A)
 1.04A 4odoC-4hneA:
undetectable		 4odoC-4hneA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  26
ASP A  37
ILE A  56
TYR A  82
PHE A  99
 None
 0.74A 4odoC-4iqcA:
11.5		 4odoC-4iqcA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A3886
LEU A3879
LEU A3915
LEU A3847
LEU A3964
 None
 0.89A 4odoC-4kc5A:
undetectable		 4odoC-4kc5A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  56
ASP A  67
ILE A  86
TYR A 112
PHE A 129
 FK5  A 201 (-4.1A)
FK5  A 201 (-3.4A)
FK5  A 201 (-3.8A)
FK5  A 201 (-4.5A)
FK5  A 201 (-4.9A)
 0.36A 4odoC-4nnrA:
12.9		 4odoC-4nnrA:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD

(Thermus
thermophilus) 		PF00254
(FKBP_C) 		10 TYR A  13
LEU A  15
ASP A  23
LEU A  27
LEU A  36
ILE A  37
LEU A  40
TYR A  63
LEU A 121
PHE A 128
 None
 0.62A 4odoC-4odmA:
21.2		 4odoC-4odmA:
97.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA

(Homo sapiens;
Thermus
thermophilus) 		PF00254
(FKBP_C) 		9 TYR A  13
LEU A  15
ASP A  23
LEU A  27
LEU A  36
ILE A  37
LEU A  40
TYR A  63
PHE A  80
 FK5  A 201 ( 3.6A)
FK5  A 201 (-3.9A)
FK5  A 201 (-3.6A)
FK5  A 201 (-4.1A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.9A)
FK5  A 201 (-4.5A)
FK5  A 201 (-4.4A)
FK5  A 201 ( 4.8A)
 0.42A 4odoC-4odrA:
18.3		 4odoC-4odrA:
65.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
ILE A  87
TYR A 113
PHE A 130
 None
 0.73A 4odoC-4r0xA:
11.2		 4odoC-4r0xA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A  90
LEU A 102
ILE A 127
LEU A 156
PHE A  98
 None
 1.01A 4odoC-4v2eA:
undetectable		 4odoC-4v2eA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wa8 FLAP ENDONUCLEASE 1

(Methanopyrus
kandleri) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 LEU A 224
LEU A   9
ILE A  10
LEU A   6
LEU A 209
 None
 1.08A 4odoC-4wa8A:
undetectable		 4odoC-4wa8A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		5 LEU B 400
LEU B 390
ILE B 273
LEU B 386
PHE B 423
 None
 1.05A 4odoC-4xmmB:
undetectable		 4odoC-4xmmB:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxb INSULIN RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 LEU E 354
LEU E 330
LEU E 340
ILE E 342
PHE E 381
 None
 1.09A 4odoC-4zxbE:
undetectable		 4odoC-4zxbE:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		5 LEU A 512
LEU A 525
ILE A 522
LEU A 521
LEU A 576
 None
 1.00A 4odoC-4zxlA:
undetectable		 4odoC-4zxlA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Coccidioides
immitis) 		PF00254
(FKBP_C) 		5 TYR C  36
ASP C  56
ILE C  74
TYR C 100
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.7A)
 0.45A 4odoC-5b8iC:
11.0		 4odoC-5b8iC:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eut PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA,ENDOLYSIN,PH
OSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Escherichia
virus T4;
Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		5 LEU A 203
LEU A 385
ILE A 427
LEU A 430
LEU A 397
 None
 1.04A 4odoC-5eutA:
undetectable		 4odoC-5eutA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiw CYTOCHROME P450
CYP260B1

(Sorangium
cellulosum) 		PF00067
(p450) 		5 LEU A 237
LEU A 244
LEU A 356
LEU A 355
PHE A 127
 None
 0.75A 4odoC-5hiwA:
undetectable		 4odoC-5hiwA:
18.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  26
ASP A  37
ILE A  56
TYR A  82
LEU A 139
PHE A 146
 None
 0.49A 4odoC-5i7pA:
7.8		 4odoC-5i7pA:
32.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE 16
KDA PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE,PEPTIDYL-P
ROLYL CIS-TRANS
ISOMERASE FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  26
ASP A  37
ILE A  56
TYR A  82
LEU A 140
PHE A 147
 None
 0.54A 4odoC-5i7qA:
7.9		 4odoC-5i7qA:
30.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		5 TYR A  30
ASP A  41
ILE A  60
TYR A  97
PHE A 114
 None
 0.64A 4odoC-5i98A:
10.8		 4odoC-5i98A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		5 LEU A 856
LEU A 800
LEU A 815
ILE A 816
LEU A 847
 None
 1.08A 4odoC-5irmA:
undetectable		 4odoC-5irmA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6e FK506-BINDING
PROTEIN 1A

(Aspergillus
fumigatus) 		PF00254
(FKBP_C) 		5 TYR A  27
ASP A  38
ILE A  57
TYR A  83
PHE A 100
 None
 0.59A 4odoC-5j6eA:
11.3		 4odoC-5j6eA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k97 FLAP ENDONUCLEASE 1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 LEU A 226
LEU A 209
ILE A 212
LEU A 213
LEU A   9
 None
 0.95A 4odoC-5k97A:
undetectable		 4odoC-5k97A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 ASP B 677
LEU B 461
ILE B 462
LEU B 458
PHE B 638
 None
 1.08A 4odoC-5kyuB:
undetectable		 4odoC-5kyuB:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		5 LEU A 140
ASP A 270
ILE A  41
LEU A  95
LEU A  52
 None
 1.08A 4odoC-5l9sA:
undetectable		 4odoC-5l9sA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3l EXTRACELLULAR
GLOBIN-3
HEMOGLOBIN CHAIN D1

(Lumbricus
terrestris) 		PF00042
(Globin) 		5 LEU C  22
LEU C  78
LEU C 120
LEU C 124
LEU D  15
 None
HEM  C 201 ( 4.9A)
None
None
None
 1.04A 4odoC-5m3lC:
undetectable		 4odoC-5m3lC:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Psychrobacter
arcticus) 		PF01634
(HisG) 		5 LEU E  26
ILE E 219
LEU E 216
LEU E  41
PHE E  88
 None
 0.87A 4odoC-5m8hE:
undetectable		 4odoC-5m8hE:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Psychrobacter
arcticus) 		PF01634
(HisG) 		5 LEU E  26
LEU E 215
LEU E 216
LEU E  41
PHE E  88
 None
 0.98A 4odoC-5m8hE:
undetectable		 4odoC-5m8hE:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens) 		no annotation 5 TYR C 298
ASP C 352
LEU C 300
ILE C 128
TYR C 124
 SCY  C  88 (-4.2A)
None
None
13X  C 500 (-3.9A)
13X  C 500 (-4.9A)
 1.06A 4odoC-5mg5C:
undetectable		 4odoC-5mg5C:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwn TYPE VI SECRETION
PROTEIN

(Escherichia
coli) 		PF05936
(T6SS_VasE) 		5 LEU A 271
LEU A 276
LEU A 305
LEU A 302
LEU A 208
 None
 1.04A 4odoC-5mwnA:
undetectable		 4odoC-5mwnA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 ASP A 220
LEU A 240
LEU A 247
ILE A 249
LEU A 209
 None
 1.06A 4odoC-5n6uA:
undetectable		 4odoC-5n6uA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		6 LEU E  45
LEU E  16
ILE E  15
TYR E 121
LEU E  82
PHE E  49
 None
 1.15A 4odoC-5u8sE:
undetectable		 4odoC-5u8sE:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		6 LEU E 359
LEU E 401
ILE E 404
LEU E 396
LEU E 329
PHE E 392
 None
 1.41A 4odoC-5u8sE:
undetectable		 4odoC-5u8sE:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E 144
LEU E 130
LEU E  72
ILE E  76
LEU E  73
 None
 1.08A 4odoC-5uj7E:
undetectable		 4odoC-5uj7E:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E 144
LEU E 130
LEU E  72
ILE E  76
LEU E  73
 None
 1.08A 4odoC-5ujmE:
undetectable		 4odoC-5ujmE:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8t UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei;
Saccharomyces
cerevisiae) 		no annotation 5 TYR A  33
ASP A  44
ILE A  63
TYR A  89
PHE A 106
 8ZV  A 201 (-3.8A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-4.0A)
8ZV  A 201 (-4.6A)
8ZV  A 201 (-4.6A)
 0.32A 4odoC-5v8tA:
11.5		 4odoC-5v8tA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wti CRISPR-ASSOCIATED
PROTEIN

(Bacillus
thermoamylovorans) 		no annotation 5 LEU Z 186
LEU Z 171
ILE Z 174
LEU Z 175
LEU Z  95
 None
 0.88A 4odoC-5wtiZ:
2.0		 4odoC-5wtiZ:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		5 TYR A 147
ASP A 158
ILE A 172
TYR A 198
PHE A 215
 TLA  A 301 ( 4.4A)
TLA  A 301 (-3.7A)
TLA  A 301 (-3.4A)
None
None
 0.70A 4odoC-5xb0A:
9.3		 4odoC-5xb0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE

(Escherichia
coli) 		no annotation 5 LEU A  57
ASP A  56
LEU A  63
LEU A 100
ILE A 102
 None
 0.95A 4odoC-5z03A:
undetectable		 4odoC-5z03A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 5 TYR A  38
ASP A  49
ILE A  68
TYR A  94
PHE A 111
 None
 0.39A 4odoC-6b4pA:
10.8		 4odoC-6b4pA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus) 		no annotation 5 LEU A  39
LEU A 173
ILE A  63
LEU A  66
PHE A 214
 None
 1.08A 4odoC-6begA:
undetectable		 4odoC-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 5 ASP A 475
LEU A 390
LEU A 111
ILE A 434
LEU A 109
 None
 0.90A 4odoC-6cczA:
undetectable		 4odoC-6cczA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6df3 -

(-) 		no annotation 5 LEU C 197
ASP C 194
LEU C  92
LEU C 112
LEU C 140
 GOL  C 302 (-3.5A)
None
None
None
None
 0.97A 4odoC-6df3C:
undetectable		 4odoC-6df3C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 5 LEU A 518
LEU A 503
ILE A 504
LEU A 500
PHE A 493
 None
 1.04A 4odoC-6f5dA:
undetectable		 4odoC-6f5dA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g5i RNA-BINDING PROTEIN
PNO1

(Homo sapiens) 		no annotation 5 ASP x 135
LEU x 130
LEU x 105
ILE x  99
LEU x 103
 None
 0.97A 4odoC-6g5ix:
undetectable		 4odoC-6g5ix:
19.87