SIMILAR PATTERNS OF AMINO ACIDS FOR 4ODO_B_FK5B203

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b74 GLUTAMATE RACEMASE

(Aquifex
pyrophilus) 		PF01177
(Asp_Glu_race) 		6 ASP A   7
LEU A 234
ILE A 235
LEU A 231
LEU A  16
PHE A 224
 None
 1.45A 4odoB-1b74A:
undetectable		 4odoB-1b74A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		5 ASP A  51
LEU A  46
LEU A  65
ILE A 271
LEU A  63
 None
 0.99A 4odoB-1drtA:
undetectable		 4odoB-1drtA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A 131
ASP A 142
ILE A 159
TYR A 185
PHE A 202
 None
 0.61A 4odoB-1fd9A:
9.8		 4odoB-1fd9A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		5 TYR A  26
ASP A  37
ILE A  56
TYR A  82
PHE A  99
 None
 0.49A 4odoB-1fkkA:
11.8		 4odoB-1fkkA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6q HNRNP ARGININE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF06325
(PrmA) 		6 LEU 1 148
ASP 1 145
LEU 1 116
LEU 1  63
ILE 1 129
LEU 1 227
 None
 1.36A 4odoB-1g6q1:
undetectable		 4odoB-1g6q1:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6u INTERNALIN H

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		5 LEU A 149
LEU A 103
LEU A 116
LEU A 113
LEU A 160
 None
 1.07A 4odoB-1h6uA:
undetectable		 4odoB-1h6uA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 LEU A   8
LEU A 131
LEU A 146
LEU A 177
PHE A 198
 None
 1.08A 4odoB-1i7qA:
undetectable		 4odoB-1i7qA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		5 TYR A  92
ASP A 103
ILE A 120
TYR A 146
PHE A 163
 None
 0.69A 4odoB-1jvwA:
8.5		 4odoB-1jvwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1a FKBP52

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
ILE A  87
TYR A 113
PHE A 130
 None
 0.65A 4odoB-1n1aA:
11.1		 4odoB-1n1aA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pbk FKBP25

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A 135
ASP A 146
LEU A 162
ILE A 172
TYR A 198
PHE A 216
 RAP  A 225 (-3.9A)
RAP  A 225 (-3.0A)
RAP  A 225 (-4.8A)
RAP  A 225 (-3.9A)
RAP  A 225 (-4.6A)
None
 0.52A 4odoB-1pbkA:
11.4		 4odoB-1pbkA:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 LEU A 237
LEU A 230
LEU A 330
ILE A 333
LEU A 334
LEU A 210
 None
 1.37A 4odoB-1poxA:
undetectable		 4odoB-1poxA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A 146
ASP A 157
ILE A 174
TYR A 200
PHE A 216
 None
 0.66A 4odoB-1q6hA:
9.5		 4odoB-1q6hA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A 146
LEU A 166
ILE A 174
TYR A 200
PHE A 216
 None
 0.80A 4odoB-1q6hA:
9.5		 4odoB-1q6hA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9h FK506 BINDING
PROTEIN FAMILY

(Caenorhabditis
elegans) 		PF00254
(FKBP_C) 		5 TYR A  40
ASP A  51
ILE A  70
TYR A  96
PHE A 113
 None
 0.70A 4odoB-1r9hA:
11.4		 4odoB-1r9hA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE

(Mycobacterium
tuberculosis) 		PF01451
(LMWPc) 		5 LEU A 149
LEU A  34
LEU A  29
LEU A  85
PHE A  25
 None
 1.05A 4odoB-1u2qA:
undetectable		 4odoB-1u2qA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Arabidopsis
thaliana) 		PF00254
(FKBP_C) 		5 TYR A  37
ASP A  48
ILE A  67
TYR A  99
PHE A 121
 None
 0.57A 4odoB-1u79A:
10.7		 4odoB-1u79A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Arabidopsis
thaliana) 		PF00254
(FKBP_C) 		5 TYR A  37
LEU A  57
ILE A  67
TYR A  99
PHE A 121
 None
 0.48A 4odoB-1u79A:
10.7		 4odoB-1u79A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		5 TYR A  32
LEU A  35
LEU A 114
LEU A 208
LEU A 259
 None
None
NH3  A 403 ( 4.6A)
NH3  A 401 (-4.5A)
BOG  A 400 (-4.3A)
 0.88A 4odoB-1u7gA:
undetectable		 4odoB-1u7gA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ul1 FLAP ENDONUCLEASE-1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 LEU X 226
LEU X 209
ILE X 212
LEU X 213
LEU X   9
 None
 0.87A 4odoB-1ul1X:
undetectable		 4odoB-1ul1X:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		PF13476
(AAA_23)
no annotation 		5 LEU B 818
LEU A 133
LEU A  44
ILE A  43
LEU A  47
 None
 1.08A 4odoB-1us8B:
undetectable		 4odoB-1us8B:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdn GLUTAMINE BINDING
PROTEIN

(Escherichia
coli) 		PF00497
(SBP_bac_3) 		5 LEU A 204
LEU A 196
LEU A  41
LEU A  39
LEU A  31
 None
 1.04A 4odoB-1wdnA:
undetectable		 4odoB-1wdnA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlo SUFE PROTEIN

(Thermus
thermophilus) 		PF02657
(SufE) 		5 LEU A 107
LEU A 123
LEU A  86
LEU A   6
LEU A  25
 None
 1.10A 4odoB-1wloA:
undetectable		 4odoB-1wloA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yat FK506 BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		5 TYR A  26
ASP A  37
ILE A  56
TYR A  82
PHE A  99
 FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.3A)
FK5  A 108 ( 3.7A)
FK5  A 108 ( 4.7A)
None
 0.36A 4odoB-1yatA:
11.7		 4odoB-1yatA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g18 PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE

(Anabaena sp.) 		PF05996
(Fe_bilin_red) 		5 LEU A 240
LEU A  72
LEU A  84
ILE A  83
LEU A 223
 None
 1.01A 4odoB-2g18A:
undetectable		 4odoB-2g18A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9f PEPTIDE N-GLYCANASE

(Mus musculus) 		PF04721
(PAW) 		5 LEU A 642
ILE A 548
LEU A 537
LEU A 611
PHE A 630
 None
 1.04A 4odoB-2g9fA:
undetectable		 4odoB-2g9fA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		5 LEU A 271
ILE A 108
LEU A 105
LEU A 286
PHE A 144
 None
 1.02A 4odoB-2h98A:
undetectable		 4odoB-2h98A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 LEU A 256
LEU A 239
ILE A 236
LEU A 235
LEU A 213
 None
 0.86A 4odoB-2jgdA:
undetectable		 4odoB-2jgdA:
11.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2kfw FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD

(Escherichia
coli) 		PF00254
(FKBP_C) 		5 LEU A  32
LEU A  41
ILE A  42
LEU A  45
TYR A  68
 None
 1.05A 4odoB-2kfwA:
11.9		 4odoB-2kfwA:
41.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  56
ASP A  67
ILE A  86
TYR A 112
PHE A 129
 PEG  A 201 (-4.4A)
None
PEG  A 201 (-3.8A)
None
None
 0.52A 4odoB-2pbcA:
12.4		 4odoB-2pbcA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 TYR A 127
LEU A 163
LEU A 126
LEU A 109
LEU A 145
 None
 1.04A 4odoB-2qbyA:
undetectable		 4odoB-2qbyA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE

(Escherichia
coli) 		PF01266
(DAO) 		5 LEU A 363
LEU A 368
LEU A 331
ILE A 332
LEU A 330
 None
 1.04A 4odoB-2uzzA:
undetectable		 4odoB-2uzzA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE

(Plasmodium
falciparum) 		PF00254
(FKBP_C) 		5 TYR A  44
ASP A  56
ILE A  75
TYR A 101
PHE A 118
 FK5  A 501 (-4.1A)
FK5  A 501 (-3.4A)
FK5  A 501 (-4.3A)
FK5  A 501 (-4.7A)
FK5  A 501 (-4.8A)
 0.36A 4odoB-2vn1A:
11.6		 4odoB-2vn1A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 ASP A 480
LEU A 321
LEU A 470
ILE A 476
LEU A 491
 None
 0.85A 4odoB-2x3kA:
undetectable		 4odoB-2x3kA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xot AMPHOTERIN-INDUCED
PROTEIN 1

(Mus musculus) 		PF07679
(I-set)
PF13855
(LRR_8) 		6 LEU A 141
LEU A  91
LEU A  76
ILE A 101
LEU A  98
LEU A 125
 None
 1.39A 4odoB-2xotA:
undetectable		 4odoB-2xotA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		5 TYR A  33
ASP A  44
ILE A  63
TYR A  89
PHE A 106
 None
 0.75A 4odoB-2y78A:
11.0		 4odoB-2y78A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		5 LEU A 363
LEU A 443
LEU A 397
LEU A 433
PHE A 376
 None
 1.03A 4odoB-2ykyA:
undetectable		 4odoB-2ykyA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywn PEROXIREDOXIN-LIKE
PROTEIN

(Sulfurisphaera
tokodaii) 		PF00578
(AhpC-TSA) 		5 ASP A  10
LEU A  26
LEU A  66
ILE A  68
LEU A  33
 None
 1.09A 4odoB-2ywnA:
undetectable		 4odoB-2ywnA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		6 LEU B 201
LEU B 153
LEU B 163
ILE B 193
LEU B 191
LEU B 223
 None
 1.17A 4odoB-3a79B:
undetectable		 4odoB-3a79B:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b33 SENSOR PROTEIN

(Vibrio
parahaemolyticus) 		PF00989
(PAS) 		5 LEU A  36
ILE A  53
LEU A  52
LEU A  89
PHE A  37
 None
 0.99A 4odoB-3b33A:
2.2		 4odoB-3b33A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr8 SULFATE
ADENYLYLTRANSFERASE,
ADENYLYLSULFATE
KINASE

(Thiobacillus
denitrificans) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 LEU A  86
LEU A  16
LEU A  48
LEU A  37
PHE A  59
 None
 1.08A 4odoB-3cr8A:
2.3		 4odoB-3cr8A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1l PUTATIVE NADP
OXIDOREDUCTASE
BF3122

(Bacteroides
fragilis) 		PF03807
(F420_oxidored)
PF10728
(DUF2520) 		5 LEU A 149
LEU A 156
LEU A  22
ILE A  70
LEU A  94
 None
 1.02A 4odoB-3d1lA:
undetectable		 4odoB-3d1lA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flh UNCHARACTERIZED
PROTEIN LP_1913

(Lactobacillus
plantarum) 		PF00581
(Rhodanese) 		5 TYR A  74
LEU A  36
LEU A  61
ILE A  65
PHE A  98
 None
 1.08A 4odoB-3flhA:
undetectable		 4odoB-3flhA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		5 LEU A 271
ILE A 108
LEU A 105
LEU A 286
PHE A 144
 None
 1.02A 4odoB-3glbA:
undetectable		 4odoB-3glbA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3n KELCH-LIKE PROTEIN
11

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 LEU A 248
ILE A 249
LEU A 244
LEU A 266
PHE A 241
 None
 1.07A 4odoB-3i3nA:
undetectable		 4odoB-3i3nA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 2

(Thermus
thermophilus) 		PF01257
(2Fe-2S_thioredx) 		5 TYR 2  78
LEU 2 116
LEU 2 163
LEU 2 153
PHE 2 117
 None
 1.02A 4odoB-3i9v2:
undetectable		 4odoB-3i9v2:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11

(Homo sapiens) 		PF00621
(RhoGEF) 		5 LEU A 995
LEU A 940
LEU A 961
LEU A 987
LEU A1026
 None
 1.10A 4odoB-3kz1A:
undetectable		 4odoB-3kz1A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE

(Streptococcus
mutans) 		PF01048
(PNP_UDP_1) 		5 LEU A  26
LEU A 266
ILE A 265
LEU A 269
LEU A 177
 None
 1.01A 4odoB-3la8A:
undetectable		 4odoB-3la8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 LEU A 778
LEU A 822
LEU A 755
LEU A 752
LEU A 914
 None
 1.00A 4odoB-3lj0A:
undetectable		 4odoB-3lj0A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
ILE A  87
TYR A 113
PHE A 130
 None
 0.75A 4odoB-3o5dA:
10.0		 4odoB-3o5dA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
ILE A  87
TYR A 113
PHE A 130
 None
 0.66A 4odoB-3o5eA:
10.9		 4odoB-3o5eA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		5 TYR A  43
ASP A  55
ILE A  74
TYR A 100
PHE A 117
 None
 0.81A 4odoB-3pa7A:
10.9		 4odoB-3pa7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		5 LEU A 298
LEU A 291
LEU A 195
ILE A 191
PHE A  49
 None
 0.98A 4odoB-3q1oA:
undetectable		 4odoB-3q1oA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdk RIBULOKINASE

(Bacillus
halodurans) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 455
ILE A 459
LEU A 419
TYR A 524
LEU A 527
 None
 1.03A 4odoB-3qdkA:
undetectable		 4odoB-3qdkA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqn CONSERVED DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF05043
(Mga) 		5 LEU A  88
LEU A  25
LEU A  21
TYR A   2
LEU A   5
 None
 1.08A 4odoB-3sqnA:
undetectable		 4odoB-3sqnA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE

(Methanothermobacter
thermautotrophicus) 		PF02374
(ArsA_ATPase) 		5 LEU A  46
LEU A  36
LEU A  60
ILE A  64
LEU A  56
 None
 1.00A 4odoB-3zq6A:
undetectable		 4odoB-3zq6A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		5 TYR A 313
ASP A 324
ILE A 342
TYR A 368
PHE A 384
 None
 0.92A 4odoB-4bf8A:
10.7		 4odoB-4bf8A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A

(Homo sapiens) 		PF01201
(Ribosomal_S8e) 		5 LEU i 586
ILE i 545
LEU i 594
LEU i 608
PHE i 522
 None
 1.07A 4odoB-4d61i:
3.1		 4odoB-4d61i:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dt4 FKBP-TYPE 16 KDA
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Escherichia
coli) 		PF00254
(FKBP_C) 		5 LEU A  17
LEU A  44
LEU A  48
LEU A 129
PHE A 136
 None
 0.99A 4odoB-4dt4A:
12.0		 4odoB-4dt4A:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz3 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		5 TYR A  33
ASP A  44
ILE A  63
TYR A  89
PHE A 106
 FK5  A 201 ( 3.9A)
FK5  A 201 (-3.5A)
FK5  A 201 (-3.8A)
FK5  A 201 (-4.7A)
FK5  A 201 (-4.8A)
 0.34A 4odoB-4dz3A:
11.4		 4odoB-4dz3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 172
LEU A 464
LEU A 323
LEU A 186
PHE A 168
 None
 0.87A 4odoB-4fdhA:
undetectable		 4odoB-4fdhA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fho INTERNALIN C2

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		5 LEU A 149
LEU A 103
LEU A 116
LEU A 113
LEU A 160
 None
 1.07A 4odoB-4fhoA:
undetectable		 4odoB-4fhoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		5 LEU A 203
LEU A 385
ILE A 427
LEU A 430
LEU A 397
 LEU  A 203 ( 0.5A)
LEU  A 385 ( 0.6A)
ILE  A 427 ( 0.7A)
LEU  A 430 ( 0.6A)
LEU  A 397 ( 0.5A)
 1.02A 4odoB-4hneA:
undetectable		 4odoB-4hneA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  26
ASP A  37
ILE A  56
TYR A  82
PHE A  99
 None
 0.72A 4odoB-4iqcA:
11.5		 4odoB-4iqcA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A3886
LEU A3879
LEU A3915
LEU A3847
LEU A3964
 None
 0.97A 4odoB-4kc5A:
undetectable		 4odoB-4kc5A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  56
ASP A  67
ILE A  86
TYR A 112
PHE A 129
 FK5  A 201 (-4.1A)
FK5  A 201 (-3.4A)
FK5  A 201 (-3.8A)
FK5  A 201 (-4.5A)
FK5  A 201 (-4.9A)
 0.33A 4odoB-4nnrA:
12.9		 4odoB-4nnrA:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD

(Thermus
thermophilus) 		PF00254
(FKBP_C) 		10 TYR A  13
LEU A  15
ASP A  23
LEU A  27
LEU A  36
ILE A  37
LEU A  40
TYR A  63
LEU A 121
PHE A 128
 None
 0.63A 4odoB-4odmA:
21.7		 4odoB-4odmA:
97.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA

(Homo sapiens;
Thermus
thermophilus) 		PF00254
(FKBP_C) 		9 TYR A  13
LEU A  15
ASP A  23
LEU A  27
LEU A  36
ILE A  37
LEU A  40
TYR A  63
PHE A  80
 FK5  A 201 ( 3.6A)
FK5  A 201 (-3.9A)
FK5  A 201 (-3.6A)
FK5  A 201 (-4.1A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.9A)
FK5  A 201 (-4.5A)
FK5  A 201 (-4.4A)
FK5  A 201 ( 4.8A)
 0.38A 4odoB-4odrA:
18.4		 4odoB-4odrA:
65.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
ILE A  87
TYR A 113
PHE A 130
 None
 0.74A 4odoB-4r0xA:
11.4		 4odoB-4r0xA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A  90
LEU A 102
ILE A 127
LEU A 156
PHE A  98
 None
 1.00A 4odoB-4v2eA:
undetectable		 4odoB-4v2eA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wa8 FLAP ENDONUCLEASE 1

(Methanopyrus
kandleri) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 LEU A 224
LEU A   9
ILE A  10
LEU A   6
LEU A 209
 None
 1.02A 4odoB-4wa8A:
undetectable		 4odoB-4wa8A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxb INSULIN RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 LEU E 354
LEU E 330
LEU E 340
ILE E 342
PHE E 381
 None
 1.06A 4odoB-4zxbE:
undetectable		 4odoB-4zxbE:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		5 LEU A 512
LEU A 525
ILE A 522
LEU A 521
LEU A 576
 None
 1.05A 4odoB-4zxlA:
undetectable		 4odoB-4zxlA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Coccidioides
immitis) 		PF00254
(FKBP_C) 		5 TYR C  36
ASP C  56
ILE C  74
TYR C 100
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.7A)
 0.40A 4odoB-5b8iC:
11.0		 4odoB-5b8iC:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chs RNA-DIRECTED RNA
POLYMERASE L

(Indiana
vesiculovirus) 		PF00946
(Mononeg_RNA_pol) 		5 TYR A 218
ASP A 223
LEU A  78
LEU A  53
ILE A  50
 None
 1.07A 4odoB-5chsA:
undetectable		 4odoB-5chsA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eut PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA,ENDOLYSIN,PH
OSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Escherichia
virus T4;
Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		5 LEU A 203
LEU A 385
ILE A 427
LEU A 430
LEU A 397
 None
 1.01A 4odoB-5eutA:
undetectable		 4odoB-5eutA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 LEU B 497
LEU B 441
ILE B 471
LEU B 468
TYR B 475
 None
 1.05A 4odoB-5hb4B:
undetectable		 4odoB-5hb4B:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiw CYTOCHROME P450
CYP260B1

(Sorangium
cellulosum) 		PF00067
(p450) 		5 LEU A 237
LEU A 244
LEU A 356
LEU A 355
PHE A 127
 None
 0.75A 4odoB-5hiwA:
undetectable		 4odoB-5hiwA:
18.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  26
ASP A  37
ILE A  56
TYR A  82
LEU A 139
PHE A 146
 None
 0.51A 4odoB-5i7pA:
7.3		 4odoB-5i7pA:
32.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE 16
KDA PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE,PEPTIDYL-P
ROLYL CIS-TRANS
ISOMERASE FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  26
ASP A  37
ILE A  56
TYR A  82
LEU A 140
PHE A 147
 None
 0.56A 4odoB-5i7qA:
9.3		 4odoB-5i7qA:
30.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		5 TYR A  30
ASP A  41
ILE A  60
TYR A  97
PHE A 114
 None
 0.60A 4odoB-5i98A:
10.9		 4odoB-5i98A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6e FK506-BINDING
PROTEIN 1A

(Aspergillus
fumigatus) 		PF00254
(FKBP_C) 		5 TYR A  27
ASP A  38
ILE A  57
TYR A  83
PHE A 100
 None
 0.57A 4odoB-5j6eA:
11.3		 4odoB-5j6eA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k97 FLAP ENDONUCLEASE 1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 LEU A 226
LEU A 209
ILE A 212
LEU A 213
LEU A   9
 None
 0.95A 4odoB-5k97A:
undetectable		 4odoB-5k97A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 LEU E 354
LEU E 330
LEU E 340
ILE E 342
PHE E 381
 None
 1.10A 4odoB-5kqvE:
undetectable		 4odoB-5kqvE:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l80 MATERNAL PROTEIN
EXUPERANTIA,MATERNAL
PROTEIN EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 5 LEU A 135
LEU A  28
ILE A  34
LEU A  35
LEU A 119
 None
 1.10A 4odoB-5l80A:
undetectable		 4odoB-5l80A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		5 LEU A 244
LEU A 288
ILE A 216
LEU A 282
LEU A 273
 None
 1.10A 4odoB-5lmzA:
undetectable		 4odoB-5lmzA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3l EXTRACELLULAR
GLOBIN-3
HEMOGLOBIN CHAIN D1

(Lumbricus
terrestris) 		PF00042
(Globin) 		5 LEU C  22
LEU C  78
LEU C 120
LEU C 124
LEU D  15
 None
HEM  C 201 ( 4.9A)
None
None
None
 1.00A 4odoB-5m3lC:
undetectable		 4odoB-5m3lC:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Psychrobacter
arcticus) 		PF01634
(HisG) 		5 LEU E  26
LEU E 215
LEU E 216
LEU E  41
PHE E  88
 None
 0.96A 4odoB-5m8hE:
undetectable		 4odoB-5m8hE:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9u DEHYDROASCORBATE
REDUCTASE FAMILY
PROTEIN

(Populus
trichocarpa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 LEU A 164
LEU A 157
LEU A 127
LEU A 123
PHE A 109
 None
 1.06A 4odoB-5n9uA:
undetectable		 4odoB-5n9uA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		5 LEU E  45
LEU E  16
ILE E  15
TYR E 121
PHE E  49
 None
 0.93A 4odoB-5u8sE:
undetectable		 4odoB-5u8sE:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E 144
LEU E 130
LEU E  72
ILE E  76
LEU E  73
 None
 1.05A 4odoB-5uj7E:
undetectable		 4odoB-5uj7E:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E 144
LEU E 130
LEU E  72
ILE E  76
LEU E  73
 None
 1.05A 4odoB-5ujmE:
undetectable		 4odoB-5ujmE:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8t UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei;
Saccharomyces
cerevisiae) 		no annotation 5 TYR A  33
ASP A  44
ILE A  63
TYR A  89
PHE A 106
 8ZV  A 201 (-3.8A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-4.0A)
8ZV  A 201 (-4.6A)
8ZV  A 201 (-4.6A)
 0.32A 4odoB-5v8tA:
11.5		 4odoB-5v8tA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve6 TYROSINE-PROTEIN
KINASE SGK223

(Homo sapiens) 		no annotation 5 ASP A1145
LEU A1260
LEU A1129
ILE A1214
LEU A1133
 None
 1.09A 4odoB-5ve6A:
undetectable		 4odoB-5ve6A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wti CRISPR-ASSOCIATED
PROTEIN

(Bacillus
thermoamylovorans) 		no annotation 5 LEU Z 186
LEU Z 171
ILE Z 174
LEU Z 175
LEU Z  95
 None
 0.91A 4odoB-5wtiZ:
undetectable		 4odoB-5wtiZ:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		5 TYR A 147
ASP A 158
ILE A 172
TYR A 198
PHE A 215
 TLA  A 301 ( 4.4A)
TLA  A 301 (-3.7A)
TLA  A 301 (-3.4A)
None
None
 0.66A 4odoB-5xb0A:
9.4		 4odoB-5xb0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE

(Escherichia
coli) 		no annotation 5 LEU A  57
ASP A  56
LEU A  63
LEU A 100
ILE A 102
 None
 0.97A 4odoB-5z03A:
undetectable		 4odoB-5z03A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 5 TYR A  38
ASP A  49
ILE A  68
TYR A  94
PHE A 111
 None
 0.40A 4odoB-6b4pA:
10.9		 4odoB-6b4pA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 5 ASP A 475
LEU A 390
LEU A 111
ILE A 434
LEU A 109
 None
 0.93A 4odoB-6cczA:
undetectable		 4odoB-6cczA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 5 LEU A 518
LEU A 503
ILE A 504
LEU A 500
PHE A 493
 None
 0.98A 4odoB-6f5dA:
undetectable		 4odoB-6f5dA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g5i RNA-BINDING PROTEIN
PNO1

(Homo sapiens) 		no annotation 5 ASP x 135
LEU x 130
LEU x 105
ILE x  99
LEU x 103
 None
 1.00A 4odoB-6g5ix:
undetectable		 4odoB-6g5ix:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b35 PROTEIN (CRICKET
PARALYSIS VIRUS,
VP1)

(Cricket
paralysis virus) 		PF08762
(CRPV_capsid) 		3 ALA A  13
GLN A   6
GLY A   3
 None
 0.44A 4odoC-1b35A:
0.0		 4odoC-1b35A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b35 PROTEIN (CRICKET
PARALYSIS VIRUS,
VP1)
PROTEIN (CRICKET
PARALYSIS VIRUS,
VP3)

(Cricket
paralysis virus) 		PF08762
(CRPV_capsid)
no annotation 		3 ALA A 111
GLN C  17
GLY C  18
 None
 0.55A 4odoC-1b35A:
0.0		 4odoC-1b35A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		3 ALA A 196
GLN A 868
GLY A 848
 None
 0.63A 4odoC-1c7tA:
0.0		 4odoC-1c7tA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		3 ALA A  88
GLN A 124
GLY A 232
 None
 0.59A 4odoC-1dabA:
0.0		 4odoC-1dabA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		3 ALA A 357
GLN A 287
GLY A 261
 None
 0.51A 4odoC-1dedA:
0.0		 4odoC-1dedA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ALA A 448
GLN A 440
GLY A 754
 None
PGD  A 782 (-4.4A)
PGD  A 782 (-3.8A)
 0.62A 4odoC-1dmsA:
0.0		 4odoC-1dmsA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
GAMMA

(Methanosarcina
barkeri) 		PF02240
(MCR_gamma) 		3 ALA C3045
GLN C3189
GLY C3153
 None
 0.65A 4odoC-1e6yC:
0.0		 4odoC-1e6yC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ALA A 448
GLN A 440
GLY A 754
 None
MGD  A1001 (-4.3A)
MGD  A1001 (-3.6A)
 0.64A 4odoC-1eu1A:
0.0		 4odoC-1eu1A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanothermobacter
thermautotrophicus) 		PF00296
(Bac_luciferase) 		3 ALA A 161
GLN A 296
GLY A   4
 None
 0.63A 4odoC-1f07A:
0.0		 4odoC-1f07A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)

(Sus scrofa) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		3 ALA A 331
GLN A 431
GLY A 434
 None
 0.56A 4odoC-1fblA:
undetectable		 4odoC-1fblA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpz CYCLIN-DEPENDENT
KINASE INHIBITOR 3

(Homo sapiens) 		PF05706
(CDKN3) 		3 ALA A 167
GLN A 185
GLY A 112
 None
 0.60A 4odoC-1fpzA:
undetectable		 4odoC-1fpzA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		3 ALA A 304
GLN A 244
GLY A 243
 None
 0.61A 4odoC-1g0vA:
undetectable		 4odoC-1g0vA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkp HYDANTOINASE

(Thermus sp.) 		PF01979
(Amidohydro_1) 		3 ALA A 275
GLN A 194
GLY A 191
 None
 0.57A 4odoC-1gkpA:
undetectable		 4odoC-1gkpA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		3 ALA A 155
GLN A 356
GLY A 357
 None
 0.51A 4odoC-1idjA:
undetectable		 4odoC-1idjA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		3 ALA A 704
GLN A  59
GLY A  56
 None
 0.65A 4odoC-1ileA:
undetectable		 4odoC-1ileA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqp RFCS

(Pyrococcus
furiosus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		3 ALA A 162
GLN A  30
GLY A  29
 None
 0.52A 4odoC-1iqpA:
undetectable		 4odoC-1iqpA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv1 GLCNAC1P
URIDYLTRANSFERASE
ISOFORM 1: AGX1

(Homo sapiens) 		PF01704
(UDPGP) 		3 ALA A 231
GLN A 195
GLY A 168
 None
 0.62A 4odoC-1jv1A:
undetectable		 4odoC-1jv1A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcl CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		3 ALA A 357
GLN A 287
GLY A 261
 None
GLC  A1700 (-3.4A)
None
 0.40A 4odoC-1kclA:
undetectable		 4odoC-1kclA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		3 ALA A 377
GLN A 136
GLY A 133
 None
 0.60A 4odoC-1kczA:
undetectable		 4odoC-1kczA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE

(Citrobacter
amalonaticus) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		3 ALA A 377
GLN A 136
GLY A 133
 None
 0.59A 4odoC-1kkrA:
undetectable		 4odoC-1kkrA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE

(Pseudomonas sp.
KKS102) 		PF00903
(Glyoxalase) 		3 ALA B  42
GLN B 141
GLY B 191
 None
 0.53A 4odoC-1kwcB:
undetectable		 4odoC-1kwcB:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma) 		3 ALA C  44
GLN C 190
GLY C 152
 None
 0.64A 4odoC-1mroC:
undetectable		 4odoC-1mroC:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mus TN5 TRANSPOSASE

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5)
PF14706
(Tnp_DNA_bind) 		3 ALA A 169
GLN A 198
GLY A 275
 None
 0.63A 4odoC-1musA:
0.3		 4odoC-1musA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Escherichia
coli) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 ALA A 153
GLN A  33
GLY A 272
 None
 0.48A 4odoC-1oj4A:
undetectable		 4odoC-1oj4A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT

(Propionibacterium
freudenreichii) 		PF01039
(Carboxyl_trans) 		3 ALA A 161
GLN A 116
GLY A  85
 None
 0.42A 4odoC-1on9A:
undetectable		 4odoC-1on9A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otw COENZYME PQQ
SYNTHESIS PROTEIN C

(Klebsiella
pneumoniae) 		PF03070
(TENA_THI-4) 		3 ALA A 228
GLN A  44
GLY A 105
 None
 0.60A 4odoC-1otwA:
undetectable		 4odoC-1otwA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE

(Enterobacter
cloacae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ALA A 420
GLN A 404
GLY A 408
 None
None
TPP  A 600 (-4.9A)
 0.61A 4odoC-1ovmA:
undetectable		 4odoC-1ovmA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ALA A 425
GLN A 409
GLY A 413
 None
 0.62A 4odoC-1pvdA:
undetectable		 4odoC-1pvdA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcx PECTIN LYASE B

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		3 ALA A 155
GLN A 357
GLY A 358
 None
 0.49A 4odoC-1qcxA:
undetectable		 4odoC-1qcxA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		3 ALA A1248
GLN A1020
GLY A1017
 None
 0.61A 4odoC-1qhmA:
undetectable		 4odoC-1qhmA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
CYTOCHROME C OXIDASE
POLYPEPTIDE II

(Paracoccus
denitrificans) 		PF00115
(COX1)
PF00116
(COX2)
PF02790
(COX2_TM) 		3 ALA B 189
GLN A 469
GLY B  17
 None
 0.64A 4odoC-1qleB:
undetectable		 4odoC-1qleB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4c CYSTATIN C

(Homo sapiens) 		PF00031
(Cystatin) 		3 ALA A  26
GLN A  55
GLY A  11
 None
 0.62A 4odoC-1r4cA:
undetectable		 4odoC-1r4cA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum) 		PF00150
(Cellulase) 		3 ALA A 137
GLN A  99
GLY A 103
 None
 0.58A 4odoC-1rh9A:
undetectable		 4odoC-1rh9A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 ALA A 421
GLN A 664
GLY A 661
 None
 0.55A 4odoC-1sb3A:
undetectable		 4odoC-1sb3A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
CYTOLETHAL
DISTENDING TOXIN
PROTEIN C

([Haemophilus]
ducreyi) 		PF03372
(Exo_endo_phos)
PF03498
(CDtoxinA) 		3 ALA B  30
GLN B  51
GLY C 123
 None
 0.61A 4odoC-1sr4B:
1.7		 4odoC-1sr4B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ti8 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ALA A 250
GLN A 226
GLY A 225
 None
 0.65A 4odoC-1ti8A:
undetectable		 4odoC-1ti8A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3
ARP2/3 COMPLEX 34KDA
SUBUNIT

(Bos taurus) 		PF00022
(Actin)
PF04045
(P34-Arc) 		3 ALA D  16
GLN A  28
GLY A  20
 None
 0.54A 4odoC-1u2vD:
undetectable		 4odoC-1u2vD:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00106
(adh_short) 		3 ALA A 177
GLN A 145
GLY A 144
 None
 0.48A 4odoC-1uayA:
undetectable		 4odoC-1uayA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, ALPHA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF00676
(E1_dh) 		3 ALA A 188
GLN A 147
GLY A 101
 None
 0.53A 4odoC-1w85A:
undetectable		 4odoC-1w85A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		3 ALA A 375
GLN A 211
GLY A 219
 None
 0.31A 4odoC-1w8oA:
0.0		 4odoC-1w8oA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wer P120GAP

(Homo sapiens) 		PF00616
(RasGAP) 		3 ALA A 941
GLN A 878
GLY A 875
 None
 0.57A 4odoC-1werA:
undetectable		 4odoC-1werA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA

(Bacillus
subtilis) 		PF00496
(SBP_bac_5) 		3 ALA A 457
GLN A 435
GLY A 439
 None
 0.61A 4odoC-1xocA:
undetectable		 4odoC-1xocA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au3 DNA PRIMASE

(Aquifex
aeolicus) 		PF01807
(zf-CHC2)
PF08275
(Toprim_N)
PF13155
(Toprim_2) 		3 ALA A 245
GLN A 277
GLY A 226
 None
 0.61A 4odoC-2au3A:
undetectable		 4odoC-2au3A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		3 ALA A  10
GLN A  47
GLY A  43
 None
 0.59A 4odoC-2braA:
undetectable		 4odoC-2braA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		3 ALA A  20
GLN A 161
GLY A  93
 None
None
FAD  A1485 (-3.4A)
 0.56A 4odoC-2braA:
undetectable		 4odoC-2braA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3b PPIASE

(Aspergillus
fumigatus) 		PF00160
(Pro_isomerase) 		3 ALA A 120
GLN A  66
GLY A  67
 None
 0.51A 4odoC-2c3bA:
undetectable		 4odoC-2c3bA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		3 ALA A 454
GLN A 347
GLY A 360
 None
 0.61A 4odoC-2eceA:
undetectable		 4odoC-2eceA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 ALA A 330
GLN A 541
GLY A 628
 GOL  A 778 (-3.3A)
None
None
 0.61A 4odoC-2f3oA:
undetectable		 4odoC-2f3oA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8y MALATE/L-LACTATE
DEHYDROGENASES

(Escherichia
coli) 		PF02615
(Ldh_2) 		3 ALA A  43
GLN A  91
GLY A  90
 None
 0.62A 4odoC-2g8yA:
0.0		 4odoC-2g8yA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ALA A1935
GLN A1952
GLY A1872
 None
 0.64A 4odoC-2h03A:
undetectable		 4odoC-2h03A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		3 ALA A 198
GLN A 310
GLY A 307
 None
 0.54A 4odoC-2hg4A:
0.3		 4odoC-2hg4A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		3 ALA A 260
GLN A 277
GLY A 307
 None
 0.49A 4odoC-2hj0A:
undetectable		 4odoC-2hj0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmc DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		3 ALA A 152
GLN A 117
GLY A 111
 None
 0.65A 4odoC-2hmcA:
undetectable		 4odoC-2hmcA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		3 ALA A 100
GLN A 114
GLY A 121
 None
 0.57A 4odoC-2hxoA:
undetectable		 4odoC-2hxoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6j SULFOLOBUS
SOLFATARICUS PROTEIN
TYROSINE PHOSPHATASE

(Sulfolobus
solfataricus) 		PF00102
(Y_phosphatase) 		3 ALA A 122
GLN A 139
GLY A  71
 None
 0.56A 4odoC-2i6jA:
undetectable		 4odoC-2i6jA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		3 ALA A  51
GLN A 390
GLY A 394
 None
 0.63A 4odoC-2imrA:
undetectable		 4odoC-2imrA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrj HBL B PROTEIN

(Bacillus cereus) 		PF05791
(Bacillus_HBL) 		3 ALA A 269
GLN A  27
GLY A 202
 None
 0.64A 4odoC-2nrjA:
undetectable		 4odoC-2nrjA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		3 ALA A 196
GLN A 171
GLY A 341
 None
 0.63A 4odoC-2obmA:
undetectable		 4odoC-2obmA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis) 		PF00378
(ECH_1) 		3 ALA A 287
GLN A 299
GLY A 327
 None
YE1  A 997 (-3.6A)
YE1  A 997 (-3.4A)
 0.62A 4odoC-2pg8A:
undetectable		 4odoC-2pg8A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pig PUTATIVE TRANSFERASE

(Salmonella
enterica) 		no annotation 3 ALA A 101
GLN A  16
GLY A  19
 None
 0.65A 4odoC-2pigA:
undetectable		 4odoC-2pigA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tmp TISSUE INHIBITOR OF
METALLOPROTEINASES-2

(Homo sapiens) 		PF00965
(TIMP) 		3 ALA A  90
GLN A 123
GLY A 125
 None
 0.50A 4odoC-2tmpA:
undetectable		 4odoC-2tmpA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		3 ALA A 571
GLN A 587
GLY A 592
 None
 0.49A 4odoC-2vmfA:
undetectable		 4odoC-2vmfA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vml PHYCOCYANIN ALPHA
CHAIN

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		3 ALA A 130
GLN A  79
GLY A  75
 None
 0.59A 4odoC-2vmlA:
undetectable		 4odoC-2vmlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyf REPLICATIVE DNA
HELICASE

(Geobacillus
kaustophilus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		3 ALA A 209
GLN A 419
GLY A 422
 None
 0.44A 4odoC-2vyfA:
undetectable		 4odoC-2vyfA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		3 ALA A 160
GLN A 269
GLY A 266
 None
 0.54A 4odoC-2vz9A:
undetectable		 4odoC-2vz9A:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqn TESTIN

(Homo sapiens) 		PF00412
(LIM) 		3 ALA T 358
GLN T 362
GLY T 408
 None
 0.62A 4odoC-2xqnT:
undetectable		 4odoC-2xqnT:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1

(Saccharomyces
cerevisiae) 		PF12697
(Abhydrolase_6) 		3 ALA A  20
GLN A 150
GLY A 147
 None
 0.58A 4odoC-2y6vA:
undetectable		 4odoC-2y6vA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		3 ALA A 509
GLN A 692
GLY A 656
 None
 0.60A 4odoC-2yhbA:
undetectable		 4odoC-2yhbA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana) 		PF07859
(Abhydrolase_3) 		3 ALA A 197
GLN A 307
GLY A 306
 None
 0.62A 4odoC-2zsiA:
undetectable		 4odoC-2zsiA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		3 ALA A 359
GLN A 352
GLY A 349
 HEM  A1430 (-3.6A)
None
None
 0.61A 4odoC-3abbA:
undetectable		 4odoC-3abbA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b40 PROBABLE DIPEPTIDASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		3 ALA A  97
GLN A 294
GLY A 386
 None
 0.60A 4odoC-3b40A:
undetectable		 4odoC-3b40A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		3 ALA A 357
GLN A 288
GLY A 262
 None
None
GLC  A 691 (-3.6A)
 0.41A 4odoC-3bmwA:
1.6		 4odoC-3bmwA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0k PUTATIVE
POLY(3-HYDROXYBUTYRA
TE) DEPOLYMERASE
LPQC

(Bordetella
parapertussis) 		no annotation 3 ALA A 103
GLN A 149
GLY A 172
 None
SO4  A 304 (-3.8A)
SO4  A 304 (-3.2A)
 0.63A 4odoC-3d0kA:
undetectable		 4odoC-3d0kA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		3 ALA A 381
GLN A  38
GLY A 184
 None
 0.65A 4odoC-3da1A:
undetectable		 4odoC-3da1A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Vibrio cholerae) 		PF02350
(Epimerase_2) 		3 ALA A 336
GLN A 295
GLY A 292
 None
 0.57A 4odoC-3dzcA:
undetectable		 4odoC-3dzcA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edy TRIPEPTIDYL-PEPTIDAS
E 1

(Homo sapiens) 		PF09286
(Pro-kuma_activ) 		3 ALA A  41
GLN A 128
GLY A 107
 None
 0.56A 4odoC-3edyA:
undetectable		 4odoC-3edyA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3el6 ERYTHROMYCIN
DEHYDRATASE

(Saccharopolyspora
erythraea) 		PF14765
(PS-DH) 		3 ALA A 178
GLN A 173
GLY A 169
 None
 0.62A 4odoC-3el6A:
undetectable		 4odoC-3el6A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3erv PUTATIVE C39-LIKE
PEPTIDASE

(Bacillus
anthracis) 		PF13529
(Peptidase_C39_2) 		3 ALA A 138
GLN A 241
GLY A 239
 None
 0.58A 4odoC-3ervA:
undetectable		 4odoC-3ervA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpp MACROLIDE-SPECIFIC
EFFLUX PROTEIN MACA

(Escherichia
coli) 		PF16576
(HlyD_D23) 		3 ALA A  97
GLN A  71
GLY A 202
 None
 0.46A 4odoC-3fppA:
2.9		 4odoC-3fppA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go1 FAB 268-D, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ALA L  27
GLN L   6
GLY L 101
 SO4  L 209 (-3.4A)
None
None
 0.58A 4odoC-3go1L:
undetectable		 4odoC-3go1L:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		3 ALA A 424
GLN A 174
GLY A 145
 None
 0.65A 4odoC-3h0lA:
undetectable		 4odoC-3h0lA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		3 ALA P 152
GLN P 184
GLY P 243
 None
 0.58A 4odoC-3hbuP:
undetectable		 4odoC-3hbuP:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgo 12-OXOPHYTODIENOATE
REDUCTASE 3

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		3 ALA A 275
GLN A 106
GLY A  64
 None
FMN  A 401 (-3.2A)
FMN  A 401 (-3.8A)
 0.60A 4odoC-3hgoA:
undetectable		 4odoC-3hgoA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ALA A 160
GLN A 269
GLY A 266
 None
 0.55A 4odoC-3hhdA:
undetectable		 4odoC-3hhdA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmc PUTATIVE PROPHAGE
LAMBDABA04, GLYCOSYL
HYDROLASE, FAMILY 25

(Bacillus
anthracis) 		PF01183
(Glyco_hydro_25) 		3 ALA A  87
GLN A  34
GLY A  36
 None
 0.61A 4odoC-3hmcA:
undetectable		 4odoC-3hmcA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxl UNCHARACTERIZED
PROTEIN DSY3957

(Desulfitobacterium
hafniense) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		3 ALA A  82
GLN A 232
GLY A 245
 None
 0.52A 4odoC-3hxlA:
undetectable		 4odoC-3hxlA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		3 ALA M  36
GLN M 214
GLY M 210
 None
 0.57A 4odoC-3i04M:
undetectable		 4odoC-3i04M:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum) 		PF00291
(PALP) 		3 ALA A 321
GLN A 195
GLY A 194
 None
LLP  A  91 ( 4.4A)
None
 0.64A 4odoC-3iauA:
undetectable		 4odoC-3iauA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Leishmania
mexicana) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 ALA B 195
GLN B 224
GLY B 220
 None
 0.55A 4odoC-3igzB:
undetectable		 4odoC-3igzB:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iom PURINE NUCLEOSIDE
PHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF01048
(PNP_UDP_1) 		3 ALA A 110
GLN A  54
GLY A  70
 None
 0.47A 4odoC-3iomA:
undetectable		 4odoC-3iomA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		3 ALA A 457
GLN A 451
GLY A 285
 None
 0.55A 4odoC-3iwjA:
undetectable		 4odoC-3iwjA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		3 ALA A 457
GLN A 451
GLY A 285
 None
 0.49A 4odoC-3iwkA:
undetectable		 4odoC-3iwkA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jca INTEGRASE

(Mouse mammary
tumor virus) 		PF00552
(IN_DBD_C)
PF00665
(rve)
PF02022
(Integrase_Zn) 		3 ALA A  91
GLN A 154
GLY A 153
 None
 0.56A 4odoC-3jcaA:
undetectable		 4odoC-3jcaA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltj ALPHAREP-4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		3 ALA A 135
GLN A  76
GLY A  44
 None
 0.62A 4odoC-3ltjA:
undetectable		 4odoC-3ltjA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lu2 LMO2462 PROTEIN

(Listeria
monocytogenes) 		PF01244
(Peptidase_M19) 		3 ALA A  26
GLN A  44
GLY A  45
 None
 0.63A 4odoC-3lu2A:
undetectable		 4odoC-3lu2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxy 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Yersinia pestis) 		PF04166
(PdxA) 		3 ALA A 247
GLN A 277
GLY A 278
 None
 0.59A 4odoC-3lxyA:
undetectable		 4odoC-3lxyA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		3 ALA A 239
GLN A 136
GLY A 138
 None
 0.63A 4odoC-3n2cA:
undetectable		 4odoC-3n2cA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ALA A 386
GLN A 359
GLY A 320
 None
 0.58A 4odoC-3nwrA:
1.4		 4odoC-3nwrA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ome ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		3 ALA A  36
GLN A  25
GLY A  61
 None
 0.52A 4odoC-3omeA:
undetectable		 4odoC-3omeA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		3 ALA B  18
GLN B 403
GLY B 409
 None
 0.46A 4odoC-3pdiB:
undetectable		 4odoC-3pdiB:
16.16