SIMILAR PATTERNS OF AMINO ACIDS FOR 4OBW_D_SAMD601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		3 ASN A 140
ASP A 101
ASP A 336
 None
None
MN  A 491 ( 3.1A)
 0.86A 4obwD-1a0dA:
1.4		 4obwD-1a0dA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana) 		PF01261
(AP_endonuc_2) 		3 ASN A 142
ASP A 103
ASP A 338
 None
None
CO  A 491 ( 3.0A)
 0.88A 4obwD-1a0eA:
1.4		 4obwD-1a0eA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aun PR-5D

(Nicotiana
tabacum) 		PF00314
(Thaumatin) 		3 ASN A  89
ASP A  95
ASP A 199
 None
 0.87A 4obwD-1aunA:
undetectable		 4obwD-1aunA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhw XYLOSE ISOMERASE

(Actinoplanes
missouriensis) 		PF01261
(AP_endonuc_2) 		3 ASN A  92
ASP A  57
ASP A 292
 None
 0.88A 4obwD-1bhwA:
undetectable		 4obwD-1bhwA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		3 ASN A   5
ASP A  55
ASP A 261
 None
 0.74A 4obwD-1biyA:
undetectable		 4obwD-1biyA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 ASN C 346
ASP C 320
ASP C 226
 None
 0.84A 4obwD-1ea9C:
undetectable		 4obwD-1ea9C:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		3 ASN A 196
ASP A 134
ASP A 139
 None
 0.85A 4obwD-1g1aA:
5.8		 4obwD-1g1aA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5g FUSION PROTEIN

(Avian
avulavirus 1) 		PF00523
(Fusion_gly) 		3 ASN A 294
ASP A 344
ASP A  47
 None
 0.56A 4obwD-1g5gA:
undetectable		 4obwD-1g5gA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ivh ISOVALERYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ASN A 357
ASP A  40
ASP A 212
 None
 0.71A 4obwD-1ivhA:
undetectable		 4obwD-1ivhA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgs DNA BINDING RESPONSE
REGULATOR D

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		3 ASN A  94
ASP A  85
ASP A  98
 None
 0.76A 4obwD-1kgsA:
undetectable		 4obwD-1kgsA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk8 RAT SYNAPSIN I

(Rattus
norvegicus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		3 ASN A 322
ASP A 402
ASP A 397
 None
 0.63A 4obwD-1pk8A:
undetectable		 4obwD-1pk8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 ASN A 518
ASP A 463
ASP A 395
 None
CA  A 914 ( 3.4A)
CA  A 913 (-2.1A)
 0.00A 4obwD-1q5aA:
undetectable		 4obwD-1q5aA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		3 ASN A 114
ASP A 300
ASP A  65
 None
 0.82A 4obwD-1qhbA:
undetectable		 4obwD-1qhbA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASN A 950
ASP A 952
ASP A 936
 None
 0.85A 4obwD-1rpmA:
undetectable		 4obwD-1rpmA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9c PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2

(Homo sapiens) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		3 ASN A 234
ASP A  43
ASP A 178
 None
 0.68A 4obwD-1s9cA:
undetectable		 4obwD-1s9cA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbd SOYBEAN AGGLUTININ

(Glycine max) 		PF00139
(Lectin_legB) 		3 ASN A 130
ASP A  88
ASP A 215
 CA  A 601 ( 2.9A)
GAL  A 847 (-2.8A)
GAL  A 847 ( 2.9A)
 0.82A 4obwD-1sbdA:
undetectable		 4obwD-1sbdA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sl6 C-TYPE LECTIN
DC-SIGNR

(Homo sapiens) 		PF00059
(Lectin_C) 		3 ASN A 362
ASP A 367
ASP A 382
 CA  A   1 (-3.1A)
CA  A   3 ( 2.2A)
None
 0.85A 4obwD-1sl6A:
undetectable		 4obwD-1sl6A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		3 ASN A 236
ASP A 284
ASP A 562
 None
 0.87A 4obwD-1suvA:
undetectable		 4obwD-1suvA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		3 ASN A 225
ASP A 227
ASP A 357
 None
 0.86A 4obwD-1uikA:
undetectable		 4obwD-1uikA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Vibrio cholerae) 		PF01408
(GFO_IDH_MocA) 		3 ASN A 122
ASP A  93
ASP A  12
 None
 0.83A 4obwD-1xeaA:
4.8		 4obwD-1xeaA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyr TRICHODIENE SYNTHASE

(Fusarium
sporotrichioides) 		PF06330
(TRI5) 		3 ASN A 185
ASP A 100
ASP A 239
 None
 0.84A 4obwD-1yyrA:
undetectable		 4obwD-1yyrA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium) 		PF00840
(Glyco_hydro_7) 		3 ASN A 132
ASP A 129
ASP A 270
 None
 0.77A 4obwD-1z3vA:
undetectable		 4obwD-1z3vA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		3 ASN X 320
ASP X 308
ASP X 312
 None
 0.79A 4obwD-2epkX:
undetectable		 4obwD-2epkX:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h36 HYPOTHETICAL PROTEIN
SIFV0014

(Sulfolobus
islandicus
filamentous
virus) 		PF07118
(DUF1374) 		3 ASN X  58
ASP X  60
ASP X  80
 None
 0.76A 4obwD-2h36X:
undetectable		 4obwD-2h36X:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0o SER/THR PHOSPHATASE

(Anopheles
gambiae) 		PF00481
(PP2C) 		3 ASN A 472
ASP A 425
ASP A  38
 None
ZN  A 579 (-2.2A)
ZN  A 581 (-2.1A)
 0.85A 4obwD-2i0oA:
undetectable		 4obwD-2i0oA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ASN X 114
ASP X 343
ASP X 459
 None
 0.85A 4obwD-2iv2X:
2.5		 4obwD-2iv2X:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ASN A 446
ASP A 473
ASP A  59
 MGD  A3001 (-4.5A)
MGD  A3001 (-2.9A)
None
 0.82A 4obwD-2nyaA:
2.7		 4obwD-2nyaA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox9 COLLECTIN PLACENTA 1

(Mus musculus) 		PF00059
(Lectin_C) 		3 ASN A 697
ASP A 707
ASP A 723
 CA  A 801 (-3.2A)
CA  A 803 ( 2.1A)
None
 0.86A 4obwD-2ox9A:
undetectable		 4obwD-2ox9A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 ASN A 503
ASP A 593
ASP A 557
 None
 0.79A 4obwD-2q1fA:
undetectable		 4obwD-2q1fA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Paraburkholderia
phytofirmans) 		PF13407
(Peripla_BP_4) 		3 ASN A 131
ASP A 105
ASP A 266
 GAL  A 368 (-3.7A)
GAL  A 368 (-2.9A)
GAL  A 368 (-2.9A)
 0.74A 4obwD-2rjoA:
undetectable		 4obwD-2rjoA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Yersinia
enterocolitica) 		PF13416
(SBP_bac_8) 		3 ASN A  90
ASP A 388
ASP A 190
 ADA  A1433 (-3.0A)
ADA  A1432 ( 4.7A)
ADA  A1431 (-3.0A)
 0.75A 4obwD-2uvjA:
undetectable		 4obwD-2uvjA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy3 MHC CLASS I
POLYPEPTIDE-RELATED
SEQUENCE B

(Homo sapiens) 		PF00129
(MHC_I) 		3 ASN A 113
ASP A  82
ASP A  15
 None
 0.85A 4obwD-2wy3A:
undetectable		 4obwD-2wy3A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9

(Schizosaccharomyces
pombe) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		3 ASN A 338
ASP A 306
ASP A 238
 None
 0.88A 4obwD-2xpiA:
undetectable		 4obwD-2xpiA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 3 ASN A 300
ASP A 178
ASP A 401
 None
None
CA  A 629 (-2.5A)
 0.69A 4obwD-2zuxA:
undetectable		 4obwD-2zuxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt7 TRNA
(URACIL-5-)-METHYLTR
ANSFERASE

(Escherichia
coli) 		PF05958
(tRNA_U5-meth_tr) 		3 ASN A 251
ASP A 169
ASP A 166
 None
 0.87A 4obwD-3bt7A:
10.2		 4obwD-3bt7A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN
POLYPROTEIN

(Senecavirus A;
Senecavirus A) 		no annotation
PF00073
(Rhv) 		3 ASN A 243
ASP A  38
ASP B  20
 None
 0.81A 4obwD-3cjiA:
undetectable		 4obwD-3cjiA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frm UNCHARACTERIZED
CONSERVED PROTEIN

(Staphylococcus
epidermidis) 		PF13673
(Acetyltransf_10) 		3 ASN A  14
ASP A  12
ASP A 160
 None
 0.87A 4obwD-3frmA:
undetectable		 4obwD-3frmA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Enterococcus
faecium) 		PF01636
(APH) 		3 ASN A 196
ASP A 233
ASP A 222
 LLL  A 500 (-3.3A)
None
None
 0.88A 4obwD-3hamA:
undetectable		 4obwD-3hamA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Lactobacillus
brevis) 		PF13407
(Peripla_BP_4) 		3 ASN A 167
ASP A 152
ASP A 278
 None
 0.82A 4obwD-3jy6A:
2.6		 4obwD-3jy6A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 ASN A 381
ASP A 379
ASP A 431
 CA  A   1 (-3.0A)
CA  A   1 (-3.3A)
CA  A 518 (-3.2A)
 0.82A 4obwD-3lijA:
undetectable		 4obwD-3lijA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1

(Saccharomyces
cerevisiae) 		PF16499
(Melibiase_2) 		3 ASN A  38
ASP A  35
ASP A 149
 GOL  A7002 (-4.0A)
GOL  A7002 (-3.5A)
GOL  A7001 (-4.1A)
 0.88A 4obwD-3lrkA:
undetectable		 4obwD-3lrkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7a UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF02643
(DUF192) 		3 ASN A 126
ASP A 110
ASP A  84
 None
None
EDO  A 204 ( 4.7A)
 0.81A 4obwD-3m7aA:
undetectable		 4obwD-3m7aA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae) 		PF01497
(Peripla_BP_2) 		3 ASN A  76
ASP A 263
ASP A 267
 None
 0.80A 4obwD-3pshA:
undetectable		 4obwD-3pshA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2v CADHERIN-1

(Mus musculus) 		PF00028
(Cadherin) 		3 ASN A 520
ASP A 464
ASP A 344
 None
CA  A 611 ( 3.5A)
None
 0.79A 4obwD-3q2vA:
undetectable		 4obwD-3q2vA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN

(Legionella
pneumophila) 		PF13407
(Peripla_BP_4) 		3 ASN A 131
ASP A 112
ASP A  34
 None
GOL  A 317 (-2.8A)
None
 0.83A 4obwD-3rotA:
3.4		 4obwD-3rotA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE

(Borreliella
burgdorferi) 		PF01406
(tRNA-synt_1e) 		3 ASN A  18
ASP A 234
ASP A 231
 None
 0.63A 4obwD-3sp1A:
3.3		 4obwD-3sp1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		3 ASN A 262
ASP A 218
ASP A 240
 None
 0.85A 4obwD-3v7pA:
undetectable		 4obwD-3v7pA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		3 ASN A 690
ASP A 525
ASP A 519
 None
 0.88A 4obwD-3v8vA:
12.8		 4obwD-3v8vA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 ASN A2381
ASP A2329
ASP A2341
 None
 0.72A 4obwD-3vkgA:
undetectable		 4obwD-3vkgA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		3 ASN A 280
ASP A 507
ASP A 527
 MG  A1768 ( 4.9A)
MG  A1768 (-2.5A)
None
 0.84A 4obwD-4a01A:
undetectable		 4obwD-4a01A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az7 BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		3 ASN A 364
ASP A 360
ASP A 193
 None
LOG  A1614 (-3.9A)
None
 0.66A 4obwD-4az7A:
undetectable		 4obwD-4az7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azc BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		3 ASN A 808
ASP A 804
ASP A 638
 None
NGW  A2042 (-3.6A)
None
 0.71A 4obwD-4azcA:
undetectable		 4obwD-4azcA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		3 ASN A 577
ASP A 581
ASP A 550
 None
 0.76A 4obwD-4bfrA:
undetectable		 4obwD-4bfrA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE

(Homo sapiens) 		PF02668
(TauD)
PF06155
(DUF971) 		3 ASN A 190
ASP A 261
ASP A 204
 None
RUJ  A 401 ( 4.7A)
ZN  A 402 (-2.6A)
 0.75A 4obwD-4bhiA:
undetectable		 4obwD-4bhiA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9v RNF43

(Xenopus
tropicalis) 		no annotation 3 ASN A 137
ASP A 134
ASP A 168
 None
 0.86A 4obwD-4c9vA:
undetectable		 4obwD-4c9vA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN

(Bacillus
licheniformis) 		PF01839
(FG-GAP) 		3 ASN A 270
ASP A 148
ASP A 371
 None
GOL  A 611 ( 4.7A)
CA  A 601 ( 2.2A)
 0.65A 4obwD-4cagA:
undetectable		 4obwD-4cagA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cs5 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Litopenaeus
vannamei) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 ASN A 120
ASP A  97
ASP A  94
 None
 0.87A 4obwD-4cs5A:
undetectable		 4obwD-4cs5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csi CELLULASE

(Humicola grisea) 		PF00840
(Glyco_hydro_7) 		3 ASN A 136
ASP A 133
ASP A 282
 None
 0.83A 4obwD-4csiA:
undetectable		 4obwD-4csiA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4i 6-PHOSPHOFRUCTOKINAS
E

(Geobacillus
stearothermophilus) 		PF00365
(PFK) 		3 ASN A 288
ASP A 134
ASP A 307
 None
 0.82A 4obwD-4i4iA:
undetectable		 4obwD-4i4iA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		3 ASN A 230
ASP A 437
ASP A 409
 None
 0.76A 4obwD-4issA:
undetectable		 4obwD-4issA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kto ISOVALERYL-COA
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ASN A 350
ASP A  37
ASP A 205
 None
 0.85A 4obwD-4ktoA:
undetectable		 4obwD-4ktoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE

(Bacillus sp.
H-257) 		PF12146
(Hydrolase_4) 		3 ASN A 223
ASP A 231
ASP A 153
 None
 0.77A 4obwD-4lheA:
undetectable		 4obwD-4lheA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B

(Danio rerio;
Homo sapiens) 		PF08337
(Plexin_cytopl)
PF00071
(Ras) 		3 ASN A1009
ASP A1024
ASP E  69
 None
 0.63A 4obwD-4m8nA:
undetectable		 4obwD-4m8nA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		3 ASN A 363
ASP A 233
ASP A 333
 None
 0.76A 4obwD-4nz0A:
undetectable		 4obwD-4nz0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E

(Brugia malayi) 		no annotation 3 ASN A 228
ASP A 132
ASP A 140
 None
 0.88A 4obwD-4ofzA:
undetectable		 4obwD-4ofzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP

(Salmonella
enterica) 		PF00873
(ACR_tran) 		3 ASN A 201
ASP A 142
ASP A 100
 None
 0.68A 4obwD-4r86A:
undetectable		 4obwD-4r86A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		3 ASN A  72
ASP A  43
ASP A 200
 None
 0.83A 4obwD-4rsmA:
undetectable		 4obwD-4rsmA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7d ATP-DEPENDENT DNA
HELICASE Q1

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		3 ASN A 363
ASP A 382
ASP A 379
 None
 0.87A 4obwD-4u7dA:
undetectable		 4obwD-4u7dA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6

(Homo sapiens;
Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		3 ASN B 218
ASP B 220
ASP A 148
 None
 0.76A 4obwD-4um8B:
undetectable		 4obwD-4um8B:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		3 ASN A 135
ASP A 132
ASP A 281
 None
 0.84A 4obwD-4v20A:
undetectable		 4obwD-4v20A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmo XEEL PROTEIN

(Xenopus laevis) 		no annotation 3 ASN F 117
ASP F 162
ASP F 143
 None
CA  F 402 (-2.1A)
None
 0.79A 4obwD-4wmoF:
undetectable		 4obwD-4wmoF:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmy INTELECTIN-1

(Homo sapiens) 		no annotation 3 ASN A  88
ASP A 133
ASP A 114
 None
CA  A 401 (-2.1A)
None
 0.78A 4obwD-4wmyA:
undetectable		 4obwD-4wmyA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Streptobacillus
moniliformis) 		PF13407
(Peripla_BP_4) 		3 ASN A 116
ASP A  38
ASP A 237
 GAL  A 405 (-2.7A)
GAL  A 405 (-2.0A)
None
 0.74A 4obwD-4z0nA:
undetectable		 4obwD-4z0nA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		3 ASN A 540
ASP A 533
ASP A 610
 None
 0.76A 4obwD-4zgvA:
undetectable		 4obwD-4zgvA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ASN A 369
ASP A  48
ASP A 216
 None
 0.65A 4obwD-4zyjA:
undetectable		 4obwD-4zyjA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		3 ASN D 319
ASP D 307
ASP D 311
 None
 0.80A 4obwD-5a6bD:
undetectable		 4obwD-5a6bD:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq3 RHAMNOSE ABC
TRANSPORTER,
RHAMNOSE-BINDING
PROTEIN

(Actinomyces
odontolyticus) 		PF13407
(Peripla_BP_4) 		3 ASN A 331
ASP A 139
ASP A 117
 None
 0.60A 4obwD-5bq3A:
undetectable		 4obwD-5bq3A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		3 ASN A 127
ASP A 102
ASP A 503
 None
 0.77A 4obwD-5cslA:
undetectable		 4obwD-5cslA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwa TYPE-2 RESTRICTION
ENZYME AGEI

(Thalassobius
gelatinovorus) 		no annotation 3 ASN A 241
ASP A  65
ASP A 208
 None
 0.86A 4obwD-5dwaA:
undetectable		 4obwD-5dwaA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hd9 ENCAPSIDATION
PROTEIN

(Bacillus virus
phi29) 		PF05894
(Podovirus_Gp16) 		3 ASN A 158
ASP A 118
ASP A  68
 None
 0.80A 4obwD-5hd9A:
3.1		 4obwD-5hd9A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hl3 LMO2470 PROTEIN

(Listeria
monocytogenes) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		3 ASN A 227
ASP A 203
ASP A 132
 None
None
CA  A 401 (-3.0A)
 0.83A 4obwD-5hl3A:
undetectable		 4obwD-5hl3A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ASN A 230
ASP A 437
ASP A 409
 None
 0.76A 4obwD-5i8iA:
undetectable		 4obwD-5i8iA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		3 ASN A 228
ASP A 268
ASP A 240
 None
 0.73A 4obwD-5inrA:
undetectable		 4obwD-5inrA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jz7 BETA-NERVE GROWTH
FACTOR
MEDI578 SCFV, LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF00243
(NGF)
PF07686
(V-set) 		3 ASN D  52
ASP A  60
ASP A  65
 None
 0.81A 4obwD-5jz7D:
undetectable		 4obwD-5jz7D:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kws GALACTOSE-BINDING
PROTEIN

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		3 ASN A  91
ASP A  14
ASP A 212
 BGC  A 401 (-3.0A)
BGC  A 401 (-2.9A)
None
 0.75A 4obwD-5kwsA:
undetectable		 4obwD-5kwsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmx DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA34

(Saccharomyces
cerevisiae) 		PF08208
(RNA_polI_A34) 		3 ASN N 106
ASP N  94
ASP N 134
 ASN  N 106 ( 0.6A)
ASP  N  94 ( 0.5A)
ASP  N 134 ( 0.5A)
 0.84A 4obwD-5lmxN:
undetectable		 4obwD-5lmxN:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmx DNA-DIRECTED RNA
POLYMERASES I AND
III SUBUNIT
RPAC1,DNA-DIRECTED
RNA POLYMERASES I
AND III SUBUNIT
RPAC1

(Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		3 ASN C  53
ASP C  55
ASP C 269
 ASN  C  53 ( 0.6A)
ASP  C  55 ( 0.5A)
ASP  C 269 ( 0.5A)
 0.88A 4obwD-5lmxC:
undetectable		 4obwD-5lmxC:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 ASN A 556
ASP A 560
ASP A 529
 None
 0.67A 4obwD-5m6uA:
undetectable		 4obwD-5m6uA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrj BETA-XYLANASE

(Acremonium
chrysogenum) 		no annotation 3 ASN A 119
ASP A 368
ASP A 380
 None
 0.83A 4obwD-5mrjA:
undetectable		 4obwD-5mrjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmi CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B

(Bos taurus;
Bos taurus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		3 ASN C  16
ASP C  20
ASP A 333
 None
CDL  C 505 (-3.9A)
None
 0.56A 4obwD-5nmiC:
undetectable		 4obwD-5nmiC:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o51 RHO GUANYL
NUCLEOTIDE EXCHANGE
FACTOR (ROM2),
PUTATIVE

(Aspergillus
fumigatus) 		no annotation 3 ASN A1162
ASP A1184
ASP A 895
 None
 0.78A 4obwD-5o51A:
undetectable		 4obwD-5o51A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE

(Azospirillum
brasilense) 		no annotation 3 ASN A 126
ASP A  61
ASP A  97
 ADP  A 301 (-4.5A)
MG  A 302 ( 4.1A)
None
 0.80A 4obwD-5ovoA:
undetectable		 4obwD-5ovoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw9 IRON UPTAKE SYSTEM
COMPONENT EFEO

(Yersinia pestis) 		no annotation 3 ASN A 332
ASP A 373
ASP A 322
 None
 0.82A 4obwD-5tw9A:
undetectable		 4obwD-5tw9A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans) 		PF03639
(Glyco_hydro_81) 		3 ASN A 116
ASP A 216
ASP A 197
 None
 0.74A 4obwD-5v1wA:
undetectable		 4obwD-5v1wA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E

(Staphylococcus
aureus) 		no annotation 3 ASN A 290
ASP A 136
ASP A 310
 None
 0.83A 4obwD-5xoeA:
undetectable		 4obwD-5xoeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 ASN B 212
ASP B 622
ASP B 400
 None
 0.81A 4obwD-5xogB:
undetectable		 4obwD-5xogB:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 ASN B 408
ASP B 400
ASP B 622
 None
 0.72A 4obwD-5xogB:
undetectable		 4obwD-5xogB:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4j XYLOSE ISOMERASE

(Streptomyces
rubiginosus) 		PF01261
(AP_endonuc_2) 		3 ASN A  92
ASP A  57
ASP A 287
 None
None
XYL  A 402 ( 2.9A)
 0.88A 4obwD-5y4jA:
undetectable		 4obwD-5y4jA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT D

(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		no annotation
no annotation 		3 ASN D  11
ASP D 141
ASP C  22
 None
 0.85A 4obwD-6btmD:
undetectable		 4obwD-6btmD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Sus scrofa) 		no annotation 3 ASN B 203
ASP B 617
ASP B 394
 None
 0.81A 4obwD-6exvB:
undetectable		 4obwD-6exvB:
undetectable