SIMILAR PATTERNS OF AMINO ACIDS FOR 4OBW_D_SAMD601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE


(Pyrococcus
furiosus)
PF01314
(AFOR_C)
PF02730
(AFOR_N)
5 ALA A 174
GLY A 188
ILE A 163
GLY A 341
ARG A 392
None
1.07A 4obwD-1aorA:
undetectable
4obwD-1aorA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)


(Pyrococcus
furiosus)
PF01314
(AFOR_C)
PF02730
(AFOR_N)
5 ALA A 172
GLY A 186
ILE A 161
GLY A 336
ARG A 380
None
1.07A 4obwD-1b25A:
undetectable
4obwD-1b25A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Thermoanaerobacter
brockii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 242
GLY A 174
ILE A 240
GLY A 155
ASN A 264
None
1.11A 4obwD-1bxzA:
6.9
4obwD-1bxzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehi D-ALANINE:D-LACTATE
LIGASE


(Leuconostoc
mesenteroides)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
5 LYS A 116
ALA A 125
GLY A 124
ARG A 128
ASN A 295
None
1.27A 4obwD-1ehiA:
undetectable
4obwD-1ehiA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hme HIGH MOBILITY GROUP
PROTEIN FRAGMENT-B


(Rattus
norvegicus)
PF00505
(HMG_box)
5 ALA A  38
GLY A  35
ASN A  46
GLY A  42
PHE A  14
None
1.24A 4obwD-1hmeA:
undetectable
4obwD-1hmeA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig0 THIAMIN
PYROPHOSPHOKINASE


(Saccharomyces
cerevisiae)
PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding)
5 TYR A 109
ALA A  71
GLY A  70
ILE A  48
GLY A 190
None
0.95A 4obwD-1ig0A:
undetectable
4obwD-1ig0A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw7 HYPOTHETICAL PROTEIN
HP0162


(Helicobacter
pylori)
PF01709
(Transcrip_reg)
5 ALA A 119
GLY A 118
ILE A 121
GLY A  85
ARG A 225
None
1.13A 4obwD-1mw7A:
undetectable
4obwD-1mw7A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ


(Pseudomonas
aeruginosa)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
5 ALA A  49
ILE A  53
ASN A  52
ASN A  28
GLY A  24
None
1.28A 4obwD-1ofuA:
4.6
4obwD-1ofuA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE


(Escherichia
coli)
PF01156
(IU_nuc_hydro)
5 ALA A 153
GLY A 188
ILE A 167
ASN A 166
MET A 150
None
None
None
GOL  A3001 (-3.3A)
GOL  A3001 (-3.4A)
1.24A 4obwD-1q8fA:
3.0
4obwD-1q8fA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
CYTOCHROME C OXIDASE
POLYPEPTIDE II


(Paracoccus
denitrificans;
Paracoccus
denitrificans)
PF00115
(COX1)
PF00116
(COX2)
PF02790
(COX2_TM)
5 GLY A 467
ASN B  15
GLY B  16
ARG A  54
ASN A 486
None
None
None
HEA  A 601 (-3.1A)
None
1.14A 4obwD-1qleA:
undetectable
4obwD-1qleA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
5 TYR A 472
ALA A 465
GLY A 466
ASN A 246
GLY A 247
None
1.02A 4obwD-1rzvA:
3.0
4obwD-1rzvA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
SMALL SUBUNIT


(Pseudomonas
putida)
PF00111
(Fer2)
PF01799
(Fer2_2)
5 ALA A  14
GLY A  77
ILE A  16
ARG A  11
PHE A  23
None
1.29A 4obwD-1t3qA:
undetectable
4obwD-1t3qA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
SMALL SUBUNIT
QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT


(Pseudomonas
putida;
Pseudomonas
putida)
PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
5 ALA B 684
GLY B 681
ILE B 713
GLY B 688
ARG A 134
None
1.21A 4obwD-1t3qB:
undetectable
4obwD-1t3qB:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u11 PURE
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
MUTASE)


(Acetobacter
aceti)
PF00731
(AIRC)
5 ALA A 140
GLY A 139
ILE A  81
GLY A  83
ARG A  38
None
1.31A 4obwD-1u11A:
undetectable
4obwD-1u11A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukf AVIRULENCE PROTEIN
AVRPPH3


(Pseudomonas
savastanoi)
PF03543
(Peptidase_C58)
5 ALA A  99
ILE A  97
ASN A  96
GLY A 131
ASN A 139
None
1.21A 4obwD-1ukfA:
undetectable
4obwD-1ukfA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens)
PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg)
5 ALA A 176
GLY A 175
ASN A 227
ASN A 230
PHE A 231
None
1.31A 4obwD-1uwyA:
undetectable
4obwD-1uwyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0z NEURAMINIDASE

(Influenza A
virus)
PF00064
(Neur)
5 ALA A 208
GLY A 203
ILE A 229
ASN A 228
GLY A 227
None
1.32A 4obwD-1v0zA:
undetectable
4obwD-1v0zA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE


(Cavia porcellus)
PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2)
5 TYR A 214
ALA A 172
GLY A 171
ASN A 217
GLY A 174
None
None
None
NAP  A1350 (-3.9A)
NAP  A1350 (-3.2A)
0.88A 4obwD-1v3tA:
5.6
4obwD-1v3tA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226


(Pyrococcus
horikoshii)
PF13649
(Methyltransf_25)
5 TYR A   7
ALA A  46
ILE A  68
MET A  72
PHE A 116
SAM  A 302 (-4.6A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-4.4A)
1.23A 4obwD-1ve3A:
18.1
4obwD-1ve3A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes)
PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C)
5 LYS A 579
ALA A 572
GLY A 573
ILE A 485
ASN A 484
None
1.30A 4obwD-1xf1A:
undetectable
4obwD-1xf1A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438


(Mycoplasma
genitalium)
PF01420
(Methylase_S)
5 ALA A 234
GLY A 235
ASN A 273
GLY A 274
ASN A 257
None
1.26A 4obwD-1ydxA:
undetectable
4obwD-1ydxA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zem XYLITOL
DEHYDROGENASE


(Gluconobacter
oxydans)
PF13561
(adh_short_C2)
5 TYR A 157
GLY A  93
ILE A  19
GLY A  17
ARG A 198
NAD  A2263 (-4.4A)
NAD  A2263 (-3.6A)
NAD  A2263 (-3.8A)
NAD  A2263 (-3.1A)
None
1.07A 4obwD-1zemA:
6.6
4obwD-1zemA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
NONSPECIFIC
LIPID-TRANSFER
PROTEIN


(Homo sapiens;
Homo sapiens)
PF00515
(TPR_1)
PF13432
(TPR_16)
PF02036
(SCP2)
5 GLY B 139
ILE A 567
GLY A 563
ARG A 608
PHE A 579
None
1.11A 4obwD-2c0lB:
undetectable
4obwD-2c0lB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e54 ACETYLORNITHINE
AMINOTRANSFERASE


(Thermotoga
maritima)
PF00202
(Aminotran_3)
5 ALA A 239
GLY A  94
ILE A 248
ASN A  92
GLY A 241
PLP  A1001 ( 4.9A)
PLP  A1001 (-3.4A)
None
None
None
1.32A 4obwD-2e54A:
2.5
4obwD-2e54A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B


(Streptococcus
pneumoniae)
PF00905
(Transpeptidase)
5 ALA B 471
GLY B 469
MET B 616
ASN B 759
GLY B 475
None
1.26A 4obwD-2fffB:
undetectable
4obwD-2fffB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htv NEURAMINIDASE

(Influenza A
virus)
PF00064
(Neur)
5 ALA A 201
GLY A 196
ILE A 222
ASN A 221
GLY A 220
None
1.21A 4obwD-2htvA:
undetectable
4obwD-2htvA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN


(Thermoplasma
acidophilum)
PF01019
(G_glu_transpept)
5 GLY A  79
ILE A 112
GLY A  58
ARG A 201
PHE A 203
None
1.10A 4obwD-2i3oA:
undetectable
4obwD-2i3oA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jft SER-THR PHOSPHATASE
MSPP


(Mycolicibacterium
smegmatis)
PF13672
(PP2C_2)
5 ALA A 158
GLY A 110
ILE A 165
ASN A  73
GLY A 160
None
1.22A 4obwD-2jftA:
undetectable
4obwD-2jftA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I


(Staphylococcus
aureus)
PF00155
(Aminotran_1_2)
5 TYR A 126
ALA A 202
ASN A 212
GLY A 204
ASN A 172
None
PLP  A 400 (-3.5A)
None
None
PLP  A 400 (-4.0A)
1.20A 4obwD-2o1bA:
3.1
4obwD-2o1bA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oby PUTATIVE QUINONE
OXIDOREDUCTASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 120
ILE A 326
ASN A 322
GLY A 324
ASN A  40
None
None
NAP  A1400 (-3.6A)
None
None
1.24A 4obwD-2obyA:
7.1
4obwD-2obyA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcr INOSITOL-1-MONOPHOSP
HATASE


(Aquifex
aeolicus)
PF00459
(Inositol_P)
5 TYR A 127
ALA A 102
ILE A 100
ASN A  93
GLY A  90
None
1.09A 4obwD-2pcrA:
undetectable
4obwD-2pcrA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvk YJHT

(Escherichia
coli)
PF01344
(Kelch_1)
5 ALA A 110
GLY A  73
ASN A  86
ASN A 167
GLY A 125
None
1.20A 4obwD-2uvkA:
undetectable
4obwD-2uvkA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vaw CELL DIVISION
PROTEIN FTSZ


(Pseudomonas
aeruginosa)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
5 ALA A  49
ILE A  53
ASN A  52
ASN A  28
GLY A  24
None
1.21A 4obwD-2vawA:
4.4
4obwD-2vawA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri)
PF01979
(Amidohydro_1)
5 GLY A  92
ILE A 356
GLY A 358
ARG A 374
ASN A 375
None
1.03A 4obwD-2vunA:
undetectable
4obwD-2vunA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnb -

(Sus scrofa)
PF00777
(Glyco_transf_29)
5 ALA A  91
GLY A 129
ILE A 120
ASN A 117
ASN A  93
None
1.25A 4obwD-2wnbA:
undetectable
4obwD-2wnbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE


(Amycolatopsis
orientalis)
PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N)
5 ALA A 535
GLY A 534
ASN A 634
GLY A 638
ARG A 627
None
0.98A 4obwD-2x05A:
undetectable
4obwD-2x05A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2)
5 TYR A 214
ALA A 172
GLY A 171
ASN A 217
GLY A 174
None
None
None
NAP  A 701 (-3.8A)
NAP  A 701 (-3.3A)
0.97A 4obwD-2y05A:
7.3
4obwD-2y05A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbl PUTATIVE ISOMERASE

(Salmonella
enterica)
PF07221
(GlcNAc_2-epim)
5 ALA A 120
GLY A 119
ILE A  79
ASN A  83
ARG A 132
None
1.20A 4obwD-2zblA:
undetectable
4obwD-2zblA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clk TRANSCRIPTION
REGULATOR


(Lactobacillus
plantarum)
PF13377
(Peripla_BP_3)
5 ALA A 184
GLY A 185
ILE A 216
GLY A 182
PHE A 233
None
1.06A 4obwD-3clkA:
undetectable
4obwD-3clkA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)


(Salmonella
enterica)
PF09982
(DUF2219)
5 ALA A 112
GLY A 113
ILE A 108
GLY A 106
ASN A 139
None
1.29A 4obwD-3fidA:
undetectable
4obwD-3fidA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Clostridium
beijerinckii;
Thermoanaerobacter
brockii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 242
GLY A 174
ILE A 240
GLY A 155
ASN A 264
None
1.20A 4obwD-3fplA:
6.8
4obwD-3fplA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Clostridium
beijerinckii;
Thermoanaerobacter
brockii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 LYS A 340
GLY A 176
ILE A 240
GLY A 155
ASN A 266
None
1.16A 4obwD-3fsrA:
7.0
4obwD-3fsrA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA


(Escherichia
coli)
PF01156
(IU_nuc_hydro)
5 ALA A 153
GLY A 188
ILE A 167
ASN A 166
MET A 150
None
None
None
DNB  A 502 (-3.4A)
DNB  A 502 (-3.4A)
1.30A 4obwD-3g5iA:
undetectable
4obwD-3g5iA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum)
no annotation 5 ALA A 166
GLY A 167
ILE A  47
ASN A  48
GLY A  96
None
None
None
None
FMT  A 315 ( 4.2A)
1.32A 4obwD-3gjyA:
13.4
4obwD-3gjyA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT


(Eubacterium
barkeri)
PF02738
(Ald_Xan_dh_C2)
5 ALA B  25
GLY B 160
ILE B  92
ASN B  95
GLY B  81
None
1.21A 4obwD-3hrdB:
undetectable
4obwD-3hrdB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khp MAOC FAMILY PROTEIN

(Mycobacterium
tuberculosis)
PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N)
5 ALA A  67
GLY A  65
GLY A  71
ASN A  74
PHE A  73
None
1.07A 4obwD-3khpA:
undetectable
4obwD-3khpA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE


(Sulfolobus
solfataricus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A  13
GLY A 305
ILE A 135
MET A 294
GLY A   9
ADP  A 465 (-3.2A)
ADP  A 465 (-3.3A)
None
None
ADP  A 465 (-3.4A)
1.22A 4obwD-3l8kA:
undetectable
4obwD-3l8kA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica)
PF00291
(PALP)
5 ALA A 117
GLY A 119
ILE A 111
GLY A 113
ARG A 252
None
1.31A 4obwD-3r0zA:
undetectable
4obwD-3r0zA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Bacillus
anthracis)
PF00478
(IMPDH)
PF00571
(CBS)
5 ALA A 295
GLY A 294
ILE A 277
ASN A 275
GLY A 279
None
1.05A 4obwD-3tsdA:
undetectable
4obwD-3tsdA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtb PUTATIVE
OXIDOREDUCTASE


(Gluconobacter
oxydans)
PF13561
(adh_short_C2)
5 TYR A 135
ALA A 167
GLY A 232
ILE A 175
GLY A 171
None
1.18A 4obwD-3wtbA:
6.3
4obwD-3wtbA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae)
PF00149
(Metallophos)
PF02872
(5_nucleotid_C)
5 LYS A 545
ALA A 131
GLY A 132
GLY A 106
PHE A 102
None
1.31A 4obwD-3zu0A:
undetectable
4obwD-3zu0A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B


(Neisseria
meningitidis)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
5 ALA A 162
GLY A 161
ASN A 482
ASN A 536
GLY A 152
None
1.08A 4obwD-4aipA:
undetectable
4obwD-4aipA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B


(Neisseria
meningitidis)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
5 ALA A 593
GLY A 592
ASN A 542
ARG A 596
PHE A 548
None
1.19A 4obwD-4aipA:
undetectable
4obwD-4aipA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3


(Homo sapiens;
Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin)
5 ALA B 252
ILE B 516
ASN B 316
MET A 285
GLY B 518
None
None
NAG  B3320 (-4.6A)
NAG  B3320 (-3.6A)
None
1.21A 4obwD-4cakB:
undetectable
4obwD-4cakB:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL


(Mus musculus)
PF00398
(RrnaAD)
5 GLY A 168
ILE A 125
ASN A 135
ASN A 124
GLY A 123
None
1.22A 4obwD-4gc5A:
11.1
4obwD-4gc5A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Vibrio cholerae)
no annotation 5 LYS D 337
GLY D 345
ILE D 105
ASN D 170
GLY D  78
None
1.32A 4obwD-4jrmD:
undetectable
4obwD-4jrmD:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC


([Bacillus]
selenitireducens)
PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N)
5 ALA A 633
ILE A 631
GLY A 685
ARG A 644
ASN A 645
None
1.20A 4obwD-4ktpA:
undetectable
4obwD-4ktpA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4y TRANSCRIPTIONAL
REGULATOR LSRR


(Escherichia
coli)
PF04198
(Sugar-bind)
5 TYR A 156
GLY A 125
ILE A 207
MET A 129
GLY A 281
None
1.24A 4obwD-4l4yA:
5.0
4obwD-4l4yA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mag SIALIC ACID BINDING
PROTEIN


(Vibrio cholerae)
PF03480
(DctP)
5 LYS A 150
ALA A  77
GLY A  71
GLY A 101
PHE A 100
None
1.23A 4obwD-4magA:
undetectable
4obwD-4magA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE


(Vibrio cholerae)
PF13302
(Acetyltransf_3)
5 ALA A  90
ILE A  88
GLY A  69
ASN A  20
PHE A  17
None
1.00A 4obwD-4mi4A:
undetectable
4obwD-4mi4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE


(Burkholderia
cenocepacia)
PF00171
(Aldedh)
5 ALA A 189
GLY A 192
GLY A   9
ARG A 183
PHE A   6
None
1.21A 4obwD-4o6rA:
4.0
4obwD-4o6rA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE


(Burkholderia
cenocepacia)
PF00171
(Aldedh)
5 TYR A 111
ALA A 116
GLY A 113
ASN A 167
GLY A 166
None
1.31A 4obwD-4o6rA:
4.0
4obwD-4o6rA:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF01209
(Ubie_methyltran)
6 TYR A  78
GLY A 121
ILE A 149
ASN A 179
GLY A 180
ASN A 202
SAM  A 602 (-3.9A)
None
SAM  A 602 (-3.8A)
SAM  A 602 (-3.7A)
SAM  A 602 (-3.5A)
SAM  A 602 ( 4.9A)
0.97A 4obwD-4obwA:
41.0
4obwD-4obwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF01209
(Ubie_methyltran)
12 TYR A  78
LYS A  94
ALA A 119
GLY A 120
ILE A 149
ASN A 150
MET A 153
ASN A 179
GLY A 180
ARG A 201
ASN A 202
PHE A 203
SAM  A 602 (-3.9A)
SAM  A 602 (-3.3A)
SAM  A 602 (-3.2A)
SAM  A 602 (-3.4A)
SAM  A 602 (-3.8A)
SAM  A 602 (-4.9A)
SAM  A 602 (-3.7A)
SAM  A 602 (-3.7A)
SAM  A 602 (-3.5A)
None
SAM  A 602 ( 4.9A)
SAM  A 602 (-3.9A)
0.26A 4obwD-4obwA:
41.0
4obwD-4obwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn3 NEURAMINIDASE

(Influenza A
virus)
PF00064
(Neur)
5 ALA A 120
GLY A 115
ILE A 141
ASN A 140
GLY A 139
None
1.32A 4obwD-4qn3A:
undetectable
4obwD-4qn3A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Yersinia pestis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 ALA A  79
GLY A  81
MET A 237
ASN A  18
PHE A  56
None
1.07A 4obwD-4r8eA:
undetectable
4obwD-4r8eA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY


(Trichormus
variabilis)
PF13458
(Peripla_BP_6)
5 ALA A 167
GLY A 389
ILE A 159
ASN A 154
GLY A 151
None
MG  A 502 ( 4.4A)
None
None
None
1.05A 4obwD-4rdcA:
undetectable
4obwD-4rdcA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn3 TRIM5/CYCLOPHILIN A
FUSION PROTEIN/T4
LYSOZYME CHIMERA


(Macaca mulatta;
Escherichia
virus T4)
PF00643
(zf-B_box)
PF00959
(Phage_lysozyme)
5 TYR A 464
ILE A 306
MET A 304
ASN A 404
PHE A 407
None
1.30A 4obwD-4tn3A:
undetectable
4obwD-4tn3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN


(Salmonella
enterica)
PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1)
5 TYR A1615
ALA A1081
GLY A1025
ILE A1113
GLY A1088
None
1.31A 4obwD-4u48A:
undetectable
4obwD-4u48A:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA


(Shewanella
loihica)
PF01156
(IU_nuc_hydro)
5 ALA A 199
GLY A 234
ILE A 213
ASN A 212
MET A 196
1PE  A 402 ( 4.4A)
None
None
CA  A 401 ( 4.4A)
None
1.26A 4obwD-4wr2A:
undetectable
4obwD-4wr2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wva UNCHARACTERIZED
PROTEIN


(Thermus
thermophilus)
PF01204
(Trehalase)
5 ALA A 412
ILE A  39
GLY A  42
ARG A  14
ASN A  15
None
1.07A 4obwD-4wvaA:
undetectable
4obwD-4wvaA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE


(Geobacter
metallireducens)
PF01314
(AFOR_C)
PF02730
(AFOR_N)
5 ALA A 175
GLY A 188
ILE A 164
GLY A 350
ARG A 398
None
1.07A 4obwD-4z3yA:
undetectable
4obwD-4z3yA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9r OMEGA-3
POLYUNSATURATED
FATTY ACID SYNTHASE
SUBUNIT PFAD


(Shewanella
oneidensis)
PF03060
(NMO)
5 LYS A 294
ALA A 311
GLY A 310
ILE A 315
GLY A 313
None
None
None
None
FMN  A 602 (-3.4A)
1.00A 4obwD-4z9rA:
undetectable
4obwD-4z9rA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA


(Schizosaccharomyces
pombe)
PF01008
(IF-2B)
5 ALA A  81
GLY A  82
ILE A  77
ASN A  76
GLY A 213
None
1.07A 4obwD-5b04A:
4.8
4obwD-5b04A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5g SPHERULIN-4

(Aspergillus
clavatus)
PF12138
(Spherulin4)
5 TYR A 131
ALA A 128
ASN A 202
ASN A  93
GLY A  97
None
None
EDO  A 401 (-3.3A)
None
None
1.04A 4obwD-5c5gA:
undetectable
4obwD-5c5gA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN


(Homo sapiens)
PF00012
(HSP70)
5 GLY A 216
ILE A 220
ASN A 219
GLY A 210
PHE A 242
None
1.24A 4obwD-5e84A:
undetectable
4obwD-5e84A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2


(Streptococcus
gordonii)
no annotation 5 TYR B 354
GLY B 379
ILE B 297
ASN B 358
GLY B 299
None
1.21A 4obwD-5e9uB:
undetectable
4obwD-5e9uB:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5emi CELL WALL
HYDROLASE/AUTOLYSIN


(Nostoc
punctiforme)
PF01520
(Amidase_3)
5 ALA A 454
GLY A 453
ASN A 588
GLY A 456
ASN A 517
None
1.28A 4obwD-5emiA:
undetectable
4obwD-5emiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyw TRIOSEPHOSPHATE
ISOMERASE


(Litopenaeus
vannamei)
PF00121
(TIM)
5 ALA A  64
ILE A  93
ASN A  12
GLY A  43
ASN A  66
None
None
PGA  A 301 (-4.1A)
None
None
1.24A 4obwD-5eywA:
undetectable
4obwD-5eywA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
5 TYR C  79
ALA C 421
GLY C 425
ASN C 413
GLY C 419
None
1.32A 4obwD-5fseC:
undetectable
4obwD-5fseC:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL


(Homo sapiens)
PF00180
(Iso_dh)
5 ALA B 256
GLY B 257
ASN B 285
GLY B 253
ARG B 310
None
1.25A 4obwD-5grhB:
undetectable
4obwD-5grhB:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itw DIHYDROANTICAPSIN
7-DEHYDROGENASE


(Bacillus
subtilis)
PF13561
(adh_short_C2)
5 TYR A 154
GLY A  91
ILE A  19
GLY A  18
ASN A 192
None
None
SO4  A 302 (-3.9A)
SO4  A 302 (-3.5A)
None
1.24A 4obwD-5itwA:
6.9
4obwD-5itwA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfd YIIIM''6AII
CAPSID DECORATION
PROTEIN,PD_(KR)5


(synthetic
construct;
Escherichia
virus Lambda)
PF00514
(Arm)
PF02924
(HDPD)
5 ALA A 123
ILE A  88
ASN A  85
GLY A 126
ARG B 118
None
1.19A 4obwD-5mfdA:
undetectable
4obwD-5mfdA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfd YIIIM''6AII
CAPSID DECORATION
PROTEIN,PD_(KR)5


(synthetic
construct;
Escherichia
virus Lambda)
PF00514
(Arm)
PF02924
(HDPD)
5 ALA A 165
ILE A 130
ASN A 127
ARG B 118
ASN A 163
None
1.29A 4obwD-5mfdA:
undetectable
4obwD-5mfdA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfd YIIIM''6AII
CAPSID DECORATION
PROTEIN,PD_(KR)5


(synthetic
construct;
Escherichia
virus Lambda)
PF00514
(Arm)
PF02924
(HDPD)
5 ALA A 165
ILE A 130
ASN A 127
GLY A 168
ARG B 116
None
None
None
None
CA  A 406 ( 4.9A)
1.25A 4obwD-5mfdA:
undetectable
4obwD-5mfdA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfd YIIIM''6AII
CAPSID DECORATION
PROTEIN,PD_(KR)5


(synthetic
construct;
Escherichia
virus Lambda)
PF00514
(Arm)
PF02924
(HDPD)
5 ALA A 165
ILE A 130
ASN A 127
GLY A 168
ARG B 118
None
1.28A 4obwD-5mfdA:
undetectable
4obwD-5mfdA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mln ALCOHOL
DEHYDROGENASE 3


([Candida]
magnoliae)
no annotation 5 TYR A 141
ALA A 172
GLY A 230
ILE A 180
GLY A 176
None
1.29A 4obwD-5mlnA:
6.0
4obwD-5mlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum)
PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N)
5 GLY A 582
ILE A 506
ASN A 485
GLY A 595
ASN A 502
None
1.12A 4obwD-5n6uA:
undetectable
4obwD-5n6uA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7o DESFERRIOXAMINE
SIDEROPHORE
BIOSYNTHESIS PROTEIN
DFOC


(Erwinia
amylovora)
no annotation 5 GLY A  69
ILE A 106
MET A  79
ARG A  11
PHE A 116
None
0.90A 4obwD-5o7oA:
undetectable
4obwD-5o7oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE


(Mycobacterium
tuberculosis)
no annotation 5 ALA A   8
GLY A   7
ILE A  50
GLY A   4
ARG A  18
None
NAP  A 304 (-3.4A)
None
None
None
1.30A 4obwD-5tjzA:
2.6
4obwD-5tjzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1o GLUTATHIONE
REDUCTASE


(Vibrio
parahaemolyticus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 TYR A 103
LYS A 116
GLY A  17
GLY A 323
ASN A  25
None
None
FAD  A 501 (-3.2A)
None
None
1.23A 4obwD-5u1oA:
undetectable
4obwD-5u1oA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9p GLUCONATE
5-DEHYDROGENASE


(Burkholderia
cenocepacia)
PF13561
(adh_short_C2)
5 TYR A 161
GLY A  98
ILE A  24
GLY A  23
ASN A 199
TLA  A 302 ( 4.0A)
NAP  A 301 (-3.8A)
NAP  A 301 (-3.9A)
NAP  A 301 (-3.5A)
TLA  A 302 ( 3.0A)
1.15A 4obwD-5u9pA:
6.4
4obwD-5u9pA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyt ICE-BINDING PROTEIN

(Flavobacteriaceae
bacterium
3519-10)
no annotation 5 ALA A  77
GLY A  76
GLY A  55
ASN A  32
PHE A  33
None
1.13A 4obwD-5uytA:
undetectable
4obwD-5uytA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voh NADH OXIDASE

(Lactobacillus
brevis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 TYR A 318
ALA A 277
GLY A 304
ASN A 299
GLY A 112
None
None
None
None
FAD  A 501 (-2.6A)
1.25A 4obwD-5vohA:
undetectable
4obwD-5vohA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III


(Komagataella
phaffii)
no annotation 5 ALA A 181
GLY A 186
ILE A 203
GLY A 205
PHE A 221
None
1.24A 4obwD-5yatA:
6.4
4obwD-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717


(Pseudoalteromonas
arctica)
no annotation 5 ALA A 263
GLY A 264
ASN A 197
GLY A 261
ASN A 257
None
None
None
CA  A 801 ( 4.3A)
None
1.24A 4obwD-5yl7A:
2.2
4obwD-5yl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8


(Homo sapiens)
no annotation 5 ALA E1472
GLY E1468
ASN E1438
GLY E1433
ASN E1480
None
None
None
None
ATP  E2004 (-4.4A)
1.14A 4obwD-6c3pE:
undetectable
4obwD-6c3pE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8


(Homo sapiens)
no annotation 5 ALA E1472
GLY E1468
ILE E1435
ASN E1438
GLY E1433
None
1.23A 4obwD-6c3pE:
undetectable
4obwD-6c3pE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cij HIGH MOBILITY GROUP
PROTEIN B1


(Homo sapiens)
no annotation 5 ALA N 126
GLY N 123
ASN N 134
GLY N 130
PHE N 102
None
1.31A 4obwD-6cijN:
undetectable
4obwD-6cijN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN


(Cricetulus
griseus)
no annotation 5 GLY A 216
ILE A 220
ASN A 219
GLY A 210
PHE A 242
None
1.22A 4obwD-6eoeA:
undetectable
4obwD-6eoeA:
20.75