SIMILAR PATTERNS OF AMINO ACIDS FOR 4OBW_D_SAMD601_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aor | ALDEHYDE FERREDOXINOXIDOREDUCTASE (Pyrococcusfuriosus) |
PF01314(AFOR_C)PF02730(AFOR_N) | 5 | ALA A 174GLY A 188ILE A 163GLY A 341ARG A 392 | None | 1.07A | 4obwD-1aorA:undetectable | 4obwD-1aorA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b25 | PROTEIN(FORMALDEHYDEFERREDOXINOXIDOREDUCTASE) (Pyrococcusfuriosus) |
PF01314(AFOR_C)PF02730(AFOR_N) | 5 | ALA A 172GLY A 186ILE A 161GLY A 336ARG A 380 | None | 1.07A | 4obwD-1b25A:undetectable | 4obwD-1b25A:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bxz | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 242GLY A 174ILE A 240GLY A 155ASN A 264 | None | 1.11A | 4obwD-1bxzA:6.9 | 4obwD-1bxzA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ehi | D-ALANINE:D-LACTATELIGASE (Leuconostocmesenteroides) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 5 | LYS A 116ALA A 125GLY A 124ARG A 128ASN A 295 | None | 1.27A | 4obwD-1ehiA:undetectable | 4obwD-1ehiA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hme | HIGH MOBILITY GROUPPROTEIN FRAGMENT-B (Rattusnorvegicus) |
PF00505(HMG_box) | 5 | ALA A 38GLY A 35ASN A 46GLY A 42PHE A 14 | None | 1.24A | 4obwD-1hmeA:undetectable | 4obwD-1hmeA:16.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ig0 | THIAMINPYROPHOSPHOKINASE (Saccharomycescerevisiae) |
PF04263(TPK_catalytic)PF04265(TPK_B1_binding) | 5 | TYR A 109ALA A 71GLY A 70ILE A 48GLY A 190 | None | 0.95A | 4obwD-1ig0A:undetectable | 4obwD-1ig0A:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mw7 | HYPOTHETICAL PROTEINHP0162 (Helicobacterpylori) |
PF01709(Transcrip_reg) | 5 | ALA A 119GLY A 118ILE A 121GLY A 85ARG A 225 | None | 1.13A | 4obwD-1mw7A:undetectable | 4obwD-1mw7A:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ofu | CELL DIVISIONPROTEIN FTSZ (Pseudomonasaeruginosa) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | ALA A 49ILE A 53ASN A 52ASN A 28GLY A 24 | None | 1.28A | 4obwD-1ofuA:4.6 | 4obwD-1ofuA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8f | PYRIMIDINENUCLEOSIDE HYDROLASE (Escherichiacoli) |
PF01156(IU_nuc_hydro) | 5 | ALA A 153GLY A 188ILE A 167ASN A 166MET A 150 | NoneNoneNoneGOL A3001 (-3.3A)GOL A3001 (-3.4A) | 1.24A | 4obwD-1q8fA:3.0 | 4obwD-1q8fA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qle | CYTOCHROME C OXIDASEPOLYPEPTIDE I-BETACYTOCHROME C OXIDASEPOLYPEPTIDE II (Paracoccusdenitrificans;Paracoccusdenitrificans) |
PF00115(COX1)PF00116(COX2)PF02790(COX2_TM) | 5 | GLY A 467ASN B 15GLY B 16ARG A 54ASN A 486 | NoneNoneNoneHEA A 601 (-3.1A)None | 1.14A | 4obwD-1qleA:undetectable | 4obwD-1qleA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rzv | GLYCOGEN SYNTHASE 1 (Agrobacteriumtumefaciens) |
PF00534(Glycos_transf_1)PF08323(Glyco_transf_5) | 5 | TYR A 472ALA A 465GLY A 466ASN A 246GLY A 247 | None | 1.02A | 4obwD-1rzvA:3.0 | 4obwD-1rzvA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3q | QUINOLINE2-OXIDOREDUCTASESMALL SUBUNIT (Pseudomonasputida) |
PF00111(Fer2)PF01799(Fer2_2) | 5 | ALA A 14GLY A 77ILE A 16ARG A 11PHE A 23 | None | 1.29A | 4obwD-1t3qA:undetectable | 4obwD-1t3qA:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3q | QUINOLINE2-OXIDOREDUCTASESMALL SUBUNITQUINOLINE2-OXIDOREDUCTASELARGE SUBUNIT (Pseudomonasputida;Pseudomonasputida) |
PF00111(Fer2)PF01799(Fer2_2)PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | ALA B 684GLY B 681ILE B 713GLY B 688ARG A 134 | None | 1.21A | 4obwD-1t3qB:undetectable | 4obwD-1t3qB:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u11 | PURE(N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDEMUTASE) (Acetobacteraceti) |
PF00731(AIRC) | 5 | ALA A 140GLY A 139ILE A 81GLY A 83ARG A 38 | None | 1.31A | 4obwD-1u11A:undetectable | 4obwD-1u11A:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ukf | AVIRULENCE PROTEINAVRPPH3 (Pseudomonassavastanoi) |
PF03543(Peptidase_C58) | 5 | ALA A 99ILE A 97ASN A 96GLY A 131ASN A 139 | None | 1.21A | 4obwD-1ukfA:undetectable | 4obwD-1ukfA:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uwy | CARBOXYPEPTIDASE M (Homo sapiens) |
PF00246(Peptidase_M14)PF13620(CarboxypepD_reg) | 5 | ALA A 176GLY A 175ASN A 227ASN A 230PHE A 231 | None | 1.31A | 4obwD-1uwyA:undetectable | 4obwD-1uwyA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v0z | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 5 | ALA A 208GLY A 203ILE A 229ASN A 228GLY A 227 | None | 1.32A | 4obwD-1v0zA:undetectable | 4obwD-1v0zA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v3t | LEUKOTRIENE B412-HYDROXYDEHYDROGENASE/PROSTAGLANDIN15-KETO REDUCTASE (Cavia porcellus) |
PF00107(ADH_zinc_N)PF16884(ADH_N_2) | 5 | TYR A 214ALA A 172GLY A 171ASN A 217GLY A 174 | NoneNoneNoneNAP A1350 (-3.9A)NAP A1350 (-3.2A) | 0.88A | 4obwD-1v3tA:5.6 | 4obwD-1v3tA:24.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ve3 | HYPOTHETICAL PROTEINPH0226 (Pyrococcushorikoshii) |
PF13649(Methyltransf_25) | 5 | TYR A 7ALA A 46ILE A 68MET A 72PHE A 116 | SAM A 302 (-4.6A)SAM A 302 (-3.4A)SAM A 302 (-3.7A)SAM A 302 (-3.9A)SAM A 302 (-4.4A) | 1.23A | 4obwD-1ve3A:18.1 | 4obwD-1ve3A:24.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xf1 | C5A PEPTIDASE (Streptococcuspyogenes) |
PF00082(Peptidase_S8)PF02225(PA)PF06280(fn3_5)PF13585(CHU_C) | 5 | LYS A 579ALA A 572GLY A 573ILE A 485ASN A 484 | None | 1.30A | 4obwD-1xf1A:undetectable | 4obwD-1xf1A:13.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ydx | TYPE I RESTRICTIONENZYME SPECIFICITYPROTEIN MG438 (Mycoplasmagenitalium) |
PF01420(Methylase_S) | 5 | ALA A 234GLY A 235ASN A 273GLY A 274ASN A 257 | None | 1.26A | 4obwD-1ydxA:undetectable | 4obwD-1ydxA:25.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zem | XYLITOLDEHYDROGENASE (Gluconobacteroxydans) |
PF13561(adh_short_C2) | 5 | TYR A 157GLY A 93ILE A 19GLY A 17ARG A 198 | NAD A2263 (-4.4A)NAD A2263 (-3.6A)NAD A2263 (-3.8A)NAD A2263 (-3.1A)None | 1.07A | 4obwD-1zemA:6.6 | 4obwD-1zemA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c0l | PEROXISOMALTARGETING SIGNAL 1RECEPTORNONSPECIFICLIPID-TRANSFERPROTEIN (Homo sapiens;Homo sapiens) |
PF00515(TPR_1)PF13432(TPR_16)PF02036(SCP2) | 5 | GLY B 139ILE A 567GLY A 563ARG A 608PHE A 579 | None | 1.11A | 4obwD-2c0lB:undetectable | 4obwD-2c0lB:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e54 | ACETYLORNITHINEAMINOTRANSFERASE (Thermotogamaritima) |
PF00202(Aminotran_3) | 5 | ALA A 239GLY A 94ILE A 248ASN A 92GLY A 241 | PLP A1001 ( 4.9A)PLP A1001 (-3.4A)NoneNoneNone | 1.32A | 4obwD-2e54A:2.5 | 4obwD-2e54A:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fff | PENICILLIN-BINDINGPROTEIN 1B (Streptococcuspneumoniae) |
PF00905(Transpeptidase) | 5 | ALA B 471GLY B 469MET B 616ASN B 759GLY B 475 | None | 1.26A | 4obwD-2fffB:undetectable | 4obwD-2fffB:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2htv | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 5 | ALA A 201GLY A 196ILE A 222ASN A 221GLY A 220 | None | 1.21A | 4obwD-2htvA:undetectable | 4obwD-2htvA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i3o | GAMMA-GLUTAMYLTRANSFERASE RELATEDPROTEIN (Thermoplasmaacidophilum) |
PF01019(G_glu_transpept) | 5 | GLY A 79ILE A 112GLY A 58ARG A 201PHE A 203 | None | 1.10A | 4obwD-2i3oA:undetectable | 4obwD-2i3oA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jft | SER-THR PHOSPHATASEMSPP (Mycolicibacteriumsmegmatis) |
PF13672(PP2C_2) | 5 | ALA A 158GLY A 110ILE A 165ASN A 73GLY A 160 | None | 1.22A | 4obwD-2jftA:undetectable | 4obwD-2jftA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o1b | AMINOTRANSFERASE,CLASS I (Staphylococcusaureus) |
PF00155(Aminotran_1_2) | 5 | TYR A 126ALA A 202ASN A 212GLY A 204ASN A 172 | NonePLP A 400 (-3.5A)NoneNonePLP A 400 (-4.0A) | 1.20A | 4obwD-2o1bA:3.1 | 4obwD-2o1bA:24.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oby | PUTATIVE QUINONEOXIDOREDUCTASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 120ILE A 326ASN A 322GLY A 324ASN A 40 | NoneNoneNAP A1400 (-3.6A)NoneNone | 1.24A | 4obwD-2obyA:7.1 | 4obwD-2obyA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pcr | INOSITOL-1-MONOPHOSPHATASE (Aquifexaeolicus) |
PF00459(Inositol_P) | 5 | TYR A 127ALA A 102ILE A 100ASN A 93GLY A 90 | None | 1.09A | 4obwD-2pcrA:undetectable | 4obwD-2pcrA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uvk | YJHT (Escherichiacoli) |
PF01344(Kelch_1) | 5 | ALA A 110GLY A 73ASN A 86ASN A 167GLY A 125 | None | 1.20A | 4obwD-2uvkA:undetectable | 4obwD-2uvkA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vaw | CELL DIVISIONPROTEIN FTSZ (Pseudomonasaeruginosa) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | ALA A 49ILE A 53ASN A 52ASN A 28GLY A 24 | None | 1.21A | 4obwD-2vawA:4.4 | 4obwD-2vawA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vun | ENAMIDASE (Eubacteriumbarkeri) |
PF01979(Amidohydro_1) | 5 | GLY A 92ILE A 356GLY A 358ARG A 374ASN A 375 | None | 1.03A | 4obwD-2vunA:undetectable | 4obwD-2vunA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wnb | - (Sus scrofa) |
PF00777(Glyco_transf_29) | 5 | ALA A 91GLY A 129ILE A 120ASN A 117ASN A 93 | None | 1.25A | 4obwD-2wnbA:undetectable | 4obwD-2wnbA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x05 | EXO-BETA-D-GLUCOSAMINIDASE (Amycolatopsisorientalis) |
PF00703(Glyco_hydro_2)PF02837(Glyco_hydro_2_N) | 5 | ALA A 535GLY A 534ASN A 634GLY A 638ARG A 627 | None | 0.98A | 4obwD-2x05A:undetectable | 4obwD-2x05A:13.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y05 | PROSTAGLANDINREDUCTASE 1 (Homo sapiens) |
PF00107(ADH_zinc_N)PF16884(ADH_N_2) | 5 | TYR A 214ALA A 172GLY A 171ASN A 217GLY A 174 | NoneNoneNoneNAP A 701 (-3.8A)NAP A 701 (-3.3A) | 0.97A | 4obwD-2y05A:7.3 | 4obwD-2y05A:25.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zbl | PUTATIVE ISOMERASE (Salmonellaenterica) |
PF07221(GlcNAc_2-epim) | 5 | ALA A 120GLY A 119ILE A 79ASN A 83ARG A 132 | None | 1.20A | 4obwD-2zblA:undetectable | 4obwD-2zblA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clk | TRANSCRIPTIONREGULATOR (Lactobacillusplantarum) |
PF13377(Peripla_BP_3) | 5 | ALA A 184GLY A 185ILE A 216GLY A 182PHE A 233 | None | 1.06A | 4obwD-3clkA:undetectable | 4obwD-3clkA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fid | PUTATIVE OUTERMEMBRANE PROTEIN(LPXR) (Salmonellaenterica) |
PF09982(DUF2219) | 5 | ALA A 112GLY A 113ILE A 108GLY A 106ASN A 139 | None | 1.29A | 4obwD-3fidA:undetectable | 4obwD-3fidA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fpl | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Clostridiumbeijerinckii;Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 242GLY A 174ILE A 240GLY A 155ASN A 264 | None | 1.20A | 4obwD-3fplA:6.8 | 4obwD-3fplA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fsr | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Clostridiumbeijerinckii;Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LYS A 340GLY A 176ILE A 240GLY A 155ASN A 266 | None | 1.16A | 4obwD-3fsrA:7.0 | 4obwD-3fsrA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g5i | PYRIMIDINE-SPECIFICRIBONUCLEOSIDEHYDROLASE RIHA (Escherichiacoli) |
PF01156(IU_nuc_hydro) | 5 | ALA A 153GLY A 188ILE A 167ASN A 166MET A 150 | NoneNoneNoneDNB A 502 (-3.4A)DNB A 502 (-3.4A) | 1.30A | 4obwD-3g5iA:undetectable | 4obwD-3g5iA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gjy | SPERMIDINE SYNTHASE (Corynebacteriumglutamicum) |
no annotation | 5 | ALA A 166GLY A 167ILE A 47ASN A 48GLY A 96 | NoneNoneNoneNoneFMT A 315 ( 4.2A) | 1.32A | 4obwD-3gjyA:13.4 | 4obwD-3gjyA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrd | NICOTINATEDEHYDROGENASE MEDIUMMOLYBDOPTERINSUBUNIT (Eubacteriumbarkeri) |
PF02738(Ald_Xan_dh_C2) | 5 | ALA B 25GLY B 160ILE B 92ASN B 95GLY B 81 | None | 1.21A | 4obwD-3hrdB:undetectable | 4obwD-3hrdB:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khp | MAOC FAMILY PROTEIN (Mycobacteriumtuberculosis) |
PF01575(MaoC_dehydratas)PF13452(MaoC_dehydrat_N) | 5 | ALA A 67GLY A 65GLY A 71ASN A 74PHE A 73 | None | 1.07A | 4obwD-3khpA:undetectable | 4obwD-3khpA:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l8k | DIHYDROLIPOYLDEHYDROGENASE (Sulfolobussolfataricus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ALA A 13GLY A 305ILE A 135MET A 294GLY A 9 | ADP A 465 (-3.2A)ADP A 465 (-3.3A)NoneNoneADP A 465 (-3.4A) | 1.22A | 4obwD-3l8kA:undetectable | 4obwD-3l8kA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r0z | D-SERINE DEHYDRATASE (Salmonellaenterica) |
PF00291(PALP) | 5 | ALA A 117GLY A 119ILE A 111GLY A 113ARG A 252 | None | 1.31A | 4obwD-3r0zA:undetectable | 4obwD-3r0zA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsd | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH)PF00571(CBS) | 5 | ALA A 295GLY A 294ILE A 277ASN A 275GLY A 279 | None | 1.05A | 4obwD-3tsdA:undetectable | 4obwD-3tsdA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wtb | PUTATIVEOXIDOREDUCTASE (Gluconobacteroxydans) |
PF13561(adh_short_C2) | 5 | TYR A 135ALA A 167GLY A 232ILE A 175GLY A 171 | None | 1.18A | 4obwD-3wtbA:6.3 | 4obwD-3wtbA:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zu0 | NAD NUCLEOTIDASE (Haemophilusinfluenzae) |
PF00149(Metallophos)PF02872(5_nucleotid_C) | 5 | LYS A 545ALA A 131GLY A 132GLY A 106PHE A 102 | None | 1.31A | 4obwD-3zu0A:undetectable | 4obwD-3zu0A:17.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aip | FE-REGULATED PROTEINB (Neisseriameningitidis) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | ALA A 162GLY A 161ASN A 482ASN A 536GLY A 152 | None | 1.08A | 4obwD-4aipA:undetectable | 4obwD-4aipA:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aip | FE-REGULATED PROTEINB (Neisseriameningitidis) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | ALA A 593GLY A 592ASN A 542ARG A 596PHE A 548 | None | 1.19A | 4obwD-4aipA:undetectable | 4obwD-4aipA:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cak | INTEGRIN ALPHA-IIBINTEGRIN BETA-3 (Homo sapiens;Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2)PF00362(Integrin_beta)PF07965(Integrin_B_tail)PF07974(EGF_2)PF17205(PSI_integrin) | 5 | ALA B 252ILE B 516ASN B 316MET A 285GLY B 518 | NoneNoneNAG B3320 (-4.6A)NAG B3320 (-3.6A)None | 1.21A | 4obwD-4cakB:undetectable | 4obwD-4cakB:14.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gc5 | DIMETHYLADENOSINETRANSFERASE 1,MITOCHONDRIAL (Mus musculus) |
PF00398(RrnaAD) | 5 | GLY A 168ILE A 125ASN A 135ASN A 124GLY A 123 | None | 1.22A | 4obwD-4gc5A:11.1 | 4obwD-4gc5A:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jrm | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Vibrio cholerae) |
no annotation | 5 | LYS D 337GLY D 345ILE D 105ASN D 170GLY D 78 | None | 1.32A | 4obwD-4jrmD:undetectable | 4obwD-4jrmD:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ktp | GLYCOSIDE HYDROLASEFAMILY 65 CENTRALCATALYTIC ([Bacillus]selenitireducens) |
PF03632(Glyco_hydro_65m)PF03633(Glyco_hydro_65C)PF03636(Glyco_hydro_65N) | 5 | ALA A 633ILE A 631GLY A 685ARG A 644ASN A 645 | None | 1.20A | 4obwD-4ktpA:undetectable | 4obwD-4ktpA:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l4y | TRANSCRIPTIONALREGULATOR LSRR (Escherichiacoli) |
PF04198(Sugar-bind) | 5 | TYR A 156GLY A 125ILE A 207MET A 129GLY A 281 | None | 1.24A | 4obwD-4l4yA:5.0 | 4obwD-4l4yA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mag | SIALIC ACID BINDINGPROTEIN (Vibrio cholerae) |
PF03480(DctP) | 5 | LYS A 150ALA A 77GLY A 71GLY A 101PHE A 100 | None | 1.23A | 4obwD-4magA:undetectable | 4obwD-4magA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mi4 | SPERMIDINEN1-ACETYLTRANSFERASE (Vibrio cholerae) |
PF13302(Acetyltransf_3) | 5 | ALA A 90ILE A 88GLY A 69ASN A 20PHE A 17 | None | 1.00A | 4obwD-4mi4A:undetectable | 4obwD-4mi4A:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o6r | ALDEHYDEDEHYDROGENASE (Burkholderiacenocepacia) |
PF00171(Aldedh) | 5 | ALA A 189GLY A 192GLY A 9ARG A 183PHE A 6 | None | 1.21A | 4obwD-4o6rA:4.0 | 4obwD-4o6rA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o6r | ALDEHYDEDEHYDROGENASE (Burkholderiacenocepacia) |
PF00171(Aldedh) | 5 | TYR A 111ALA A 116GLY A 113ASN A 167GLY A 166 | None | 1.31A | 4obwD-4o6rA:4.0 | 4obwD-4o6rA:19.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4obw | 2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOLMETHYLASE,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF01209(Ubie_methyltran) | 6 | TYR A 78GLY A 121ILE A 149ASN A 179GLY A 180ASN A 202 | SAM A 602 (-3.9A)NoneSAM A 602 (-3.8A)SAM A 602 (-3.7A)SAM A 602 (-3.5A)SAM A 602 ( 4.9A) | 0.97A | 4obwD-4obwA:41.0 | 4obwD-4obwA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4obw | 2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOLMETHYLASE,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF01209(Ubie_methyltran) | 12 | TYR A 78LYS A 94ALA A 119GLY A 120ILE A 149ASN A 150MET A 153ASN A 179GLY A 180ARG A 201ASN A 202PHE A 203 | SAM A 602 (-3.9A)SAM A 602 (-3.3A)SAM A 602 (-3.2A)SAM A 602 (-3.4A)SAM A 602 (-3.8A)SAM A 602 (-4.9A)SAM A 602 (-3.7A)SAM A 602 (-3.7A)SAM A 602 (-3.5A)NoneSAM A 602 ( 4.9A)SAM A 602 (-3.9A) | 0.26A | 4obwD-4obwA:41.0 | 4obwD-4obwA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qn3 | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 5 | ALA A 120GLY A 115ILE A 141ASN A 140GLY A 139 | None | 1.32A | 4obwD-4qn3A:undetectable | 4obwD-4qn3A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r8e | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Yersinia pestis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ALA A 79GLY A 81MET A 237ASN A 18PHE A 56 | None | 1.07A | 4obwD-4r8eA:undetectable | 4obwD-4r8eA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rdc | AMINO ACID/AMIDE ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN, HAAT FAMILY (Trichormusvariabilis) |
PF13458(Peripla_BP_6) | 5 | ALA A 167GLY A 389ILE A 159ASN A 154GLY A 151 | None MG A 502 ( 4.4A)NoneNoneNone | 1.05A | 4obwD-4rdcA:undetectable | 4obwD-4rdcA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tn3 | TRIM5/CYCLOPHILIN AFUSION PROTEIN/T4LYSOZYME CHIMERA (Macaca mulatta;Escherichiavirus T4) |
PF00643(zf-B_box)PF00959(Phage_lysozyme) | 5 | TYR A 464ILE A 306MET A 304ASN A 404PHE A 407 | None | 1.30A | 4obwD-4tn3A:undetectable | 4obwD-4tn3A:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u48 | PUTATIVE INNERMEMBRANE LIPOPROTEIN (Salmonellaenterica) |
PF00207(A2M)PF01835(A2M_N)PF07703(A2M_N_2)PF10569(Thiol-ester_cl)PF11974(MG1) | 5 | TYR A1615ALA A1081GLY A1025ILE A1113GLY A1088 | None | 1.31A | 4obwD-4u48A:undetectable | 4obwD-4u48A:10.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wr2 | PYRIMIDINE-SPECIFICRIBONUCLEOSIDEHYDROLASE RIHA (Shewanellaloihica) |
PF01156(IU_nuc_hydro) | 5 | ALA A 199GLY A 234ILE A 213ASN A 212MET A 196 | 1PE A 402 ( 4.4A)NoneNone CA A 401 ( 4.4A)None | 1.26A | 4obwD-4wr2A:undetectable | 4obwD-4wr2A:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wva | UNCHARACTERIZEDPROTEIN (Thermusthermophilus) |
PF01204(Trehalase) | 5 | ALA A 412ILE A 39GLY A 42ARG A 14ASN A 15 | None | 1.07A | 4obwD-4wvaA:undetectable | 4obwD-4wvaA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z3y | BENZOYL-COAREDUCTASE, PUTATIVE (Geobactermetallireducens) |
PF01314(AFOR_C)PF02730(AFOR_N) | 5 | ALA A 175GLY A 188ILE A 164GLY A 350ARG A 398 | None | 1.07A | 4obwD-4z3yA:undetectable | 4obwD-4z3yA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z9r | OMEGA-3POLYUNSATURATEDFATTY ACID SYNTHASESUBUNIT PFAD (Shewanellaoneidensis) |
PF03060(NMO) | 5 | LYS A 294ALA A 311GLY A 310ILE A 315GLY A 313 | NoneNoneNoneNoneFMN A 602 (-3.4A) | 1.00A | 4obwD-4z9rA:undetectable | 4obwD-4z9rA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b04 | TRANSLATIONINITIATION FACTOREIF-2B SUBUNIT ALPHA (Schizosaccharomycespombe) |
PF01008(IF-2B) | 5 | ALA A 81GLY A 82ILE A 77ASN A 76GLY A 213 | None | 1.07A | 4obwD-5b04A:4.8 | 4obwD-5b04A:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c5g | SPHERULIN-4 (Aspergillusclavatus) |
PF12138(Spherulin4) | 5 | TYR A 131ALA A 128ASN A 202ASN A 93GLY A 97 | NoneNoneEDO A 401 (-3.3A)NoneNone | 1.04A | 4obwD-5c5gA:undetectable | 4obwD-5c5gA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e84 | 78 KDAGLUCOSE-REGULATEDPROTEIN (Homo sapiens) |
PF00012(HSP70) | 5 | GLY A 216ILE A 220ASN A 219GLY A 210PHE A 242 | None | 1.24A | 4obwD-5e84A:undetectable | 4obwD-5e84A:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e9u | GLYCOSYLTRANSFERASE-STABILIZING PROTEINGTF2 (Streptococcusgordonii) |
no annotation | 5 | TYR B 354GLY B 379ILE B 297ASN B 358GLY B 299 | None | 1.21A | 4obwD-5e9uB:undetectable | 4obwD-5e9uB:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5emi | CELL WALLHYDROLASE/AUTOLYSIN (Nostocpunctiforme) |
PF01520(Amidase_3) | 5 | ALA A 454GLY A 453ASN A 588GLY A 456ASN A 517 | None | 1.28A | 4obwD-5emiA:undetectable | 4obwD-5emiA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eyw | TRIOSEPHOSPHATEISOMERASE (Litopenaeusvannamei) |
PF00121(TIM) | 5 | ALA A 64ILE A 93ASN A 12GLY A 43ASN A 66 | NoneNonePGA A 301 (-4.1A)NoneNone | 1.24A | 4obwD-5eywA:undetectable | 4obwD-5eywA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fse | UREASE SUBUNIT ALPHA (Sporosarcinapasteurii) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 5 | TYR C 79ALA C 421GLY C 425ASN C 413GLY C 419 | None | 1.32A | 4obwD-5fseC:undetectable | 4obwD-5fseC:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5grh | ISOCITRATEDEHYDROGENASE [NAD]SUBUNIT GAMMA,MITOCHONDRIAL (Homo sapiens) |
PF00180(Iso_dh) | 5 | ALA B 256GLY B 257ASN B 285GLY B 253ARG B 310 | None | 1.25A | 4obwD-5grhB:undetectable | 4obwD-5grhB:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5itw | DIHYDROANTICAPSIN7-DEHYDROGENASE (Bacillussubtilis) |
PF13561(adh_short_C2) | 5 | TYR A 154GLY A 91ILE A 19GLY A 18ASN A 192 | NoneNoneSO4 A 302 (-3.9A)SO4 A 302 (-3.5A)None | 1.24A | 4obwD-5itwA:6.9 | 4obwD-5itwA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mfd | YIIIM''6AIICAPSID DECORATIONPROTEIN,PD_(KR)5 (syntheticconstruct;Escherichiavirus Lambda) |
PF00514(Arm)PF02924(HDPD) | 5 | ALA A 123ILE A 88ASN A 85GLY A 126ARG B 118 | None | 1.19A | 4obwD-5mfdA:undetectable | 4obwD-5mfdA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mfd | YIIIM''6AIICAPSID DECORATIONPROTEIN,PD_(KR)5 (syntheticconstruct;Escherichiavirus Lambda) |
PF00514(Arm)PF02924(HDPD) | 5 | ALA A 165ILE A 130ASN A 127ARG B 118ASN A 163 | None | 1.29A | 4obwD-5mfdA:undetectable | 4obwD-5mfdA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mfd | YIIIM''6AIICAPSID DECORATIONPROTEIN,PD_(KR)5 (syntheticconstruct;Escherichiavirus Lambda) |
PF00514(Arm)PF02924(HDPD) | 5 | ALA A 165ILE A 130ASN A 127GLY A 168ARG B 116 | NoneNoneNoneNone CA A 406 ( 4.9A) | 1.25A | 4obwD-5mfdA:undetectable | 4obwD-5mfdA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mfd | YIIIM''6AIICAPSID DECORATIONPROTEIN,PD_(KR)5 (syntheticconstruct;Escherichiavirus Lambda) |
PF00514(Arm)PF02924(HDPD) | 5 | ALA A 165ILE A 130ASN A 127GLY A 168ARG B 118 | None | 1.28A | 4obwD-5mfdA:undetectable | 4obwD-5mfdA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mln | ALCOHOLDEHYDROGENASE 3 ([Candida]magnoliae) |
no annotation | 5 | TYR A 141ALA A 172GLY A 230ILE A 180GLY A 176 | None | 1.29A | 4obwD-5mlnA:6.0 | 4obwD-5mlnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n6u | BETA-MANNOSIDASE (Dictyoglomusthermophilum) |
PF00703(Glyco_hydro_2)PF02837(Glyco_hydro_2_N) | 5 | GLY A 582ILE A 506ASN A 485GLY A 595ASN A 502 | None | 1.12A | 4obwD-5n6uA:undetectable | 4obwD-5n6uA:15.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o7o | DESFERRIOXAMINESIDEROPHOREBIOSYNTHESIS PROTEINDFOC (Erwiniaamylovora) |
no annotation | 5 | GLY A 69ILE A 106MET A 79ARG A 11PHE A 116 | None | 0.90A | 4obwD-5o7oA:undetectable | 4obwD-5o7oA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tjz | 4-HYDROXY-TETRAHYDRODIPICOLINATEREDUCTASE (Mycobacteriumtuberculosis) |
no annotation | 5 | ALA A 8GLY A 7ILE A 50GLY A 4ARG A 18 | NoneNAP A 304 (-3.4A)NoneNoneNone | 1.30A | 4obwD-5tjzA:2.6 | 4obwD-5tjzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u1o | GLUTATHIONEREDUCTASE (Vibrioparahaemolyticus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | TYR A 103LYS A 116GLY A 17GLY A 323ASN A 25 | NoneNoneFAD A 501 (-3.2A)NoneNone | 1.23A | 4obwD-5u1oA:undetectable | 4obwD-5u1oA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u9p | GLUCONATE5-DEHYDROGENASE (Burkholderiacenocepacia) |
PF13561(adh_short_C2) | 5 | TYR A 161GLY A 98ILE A 24GLY A 23ASN A 199 | TLA A 302 ( 4.0A)NAP A 301 (-3.8A)NAP A 301 (-3.9A)NAP A 301 (-3.5A)TLA A 302 ( 3.0A) | 1.15A | 4obwD-5u9pA:6.4 | 4obwD-5u9pA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uyt | ICE-BINDING PROTEIN (Flavobacteriaceaebacterium3519-10) |
no annotation | 5 | ALA A 77GLY A 76GLY A 55ASN A 32PHE A 33 | None | 1.13A | 4obwD-5uytA:undetectable | 4obwD-5uytA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5voh | NADH OXIDASE (Lactobacillusbrevis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | TYR A 318ALA A 277GLY A 304ASN A 299GLY A 112 | NoneNoneNoneNoneFAD A 501 (-2.6A) | 1.25A | 4obwD-5vohA:undetectable | 4obwD-5vohA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yat | MITOCHONDRIALALCOHOLDEHYDROGENASEISOZYME III (Komagataellaphaffii) |
no annotation | 5 | ALA A 181GLY A 186ILE A 203GLY A 205PHE A 221 | None | 1.24A | 4obwD-5yatA:6.4 | 4obwD-5yatA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yl7 | PSEUDOALTEROMONASARCTICA PAMC 21717 (Pseudoalteromonasarctica) |
no annotation | 5 | ALA A 263GLY A 264ASN A 197GLY A 261ASN A 257 | NoneNoneNone CA A 801 ( 4.3A)None | 1.24A | 4obwD-5yl7A:2.2 | 4obwD-5yl7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c3p | ATP-BINDING CASSETTESUB-FAMILY C MEMBER8 (Homo sapiens) |
no annotation | 5 | ALA E1472GLY E1468ASN E1438GLY E1433ASN E1480 | NoneNoneNoneNoneATP E2004 (-4.4A) | 1.14A | 4obwD-6c3pE:undetectable | 4obwD-6c3pE:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c3p | ATP-BINDING CASSETTESUB-FAMILY C MEMBER8 (Homo sapiens) |
no annotation | 5 | ALA E1472GLY E1468ILE E1435ASN E1438GLY E1433 | None | 1.23A | 4obwD-6c3pE:undetectable | 4obwD-6c3pE:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cij | HIGH MOBILITY GROUPPROTEIN B1 (Homo sapiens) |
no annotation | 5 | ALA N 126GLY N 123ASN N 134GLY N 130PHE N 102 | None | 1.31A | 4obwD-6cijN:undetectable | 4obwD-6cijN:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eoe | 78 KDAGLUCOSE-REGULATEDPROTEIN (Cricetulusgriseus) |
no annotation | 5 | GLY A 216ILE A 220ASN A 219GLY A 210PHE A 242 | None | 1.22A | 4obwD-6eoeA:undetectable | 4obwD-6eoeA:20.75 |