SIMILAR PATTERNS OF AMINO ACIDS FOR 4OBW_C_SAMC601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL
SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa;
Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		4 LYS A 298
ALA A 290
ASP B 380
ASN B 324
 None
 1.30A 4obwC-2fpgA:
4.1		 4obwC-2fpgA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixb ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Elizabethkingia
meningoseptica) 		PF01408
(GFO_IDH_MocA) 		4 ALA A  27
ASP A  52
MET A  57
ASN A  80
 NAD  A1445 (-3.4A)
NAD  A1445 (-2.7A)
NAD  A1445 (-4.3A)
NAD  A1445 (-4.4A)
 0.99A 4obwC-2ixbA:
3.6		 4obwC-2ixbA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01209
(Ubie_methyltran) 		5 LYS A  94
ALA A 119
ASP A 148
MET A 153
ASN A 179
 SAM  A 602 (-3.3A)
SAM  A 602 (-3.2A)
SAM  A 602 (-2.9A)
SAM  A 602 (-3.7A)
SAM  A 602 (-3.7A)
 0.34A 4obwC-4obwA:
40.4		 4obwC-4obwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pp1 LIGHT CHAIN OF FAB
FRAGMENT OF MAB 5H8
HEAVY CHAIN OF FAB
FRAGMENT OF MAB 5H8

(Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 LYS D  71
ALA D  98
ASP D 108
ASN C  34
 None
 1.40A 4obwC-4pp1D:
0.0		 4obwC-4pp1D:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n13 BROMODOMAIN-CONTAINI
NG FACTOR 1

(Candida
albicans) 		PF00439
(Bromodomain) 		4 ALA A 413
ASP A 434
MET A 433
ASN A 408
 GOL  A 502 (-3.6A)
None
None
None
 1.43A 4obwC-5n13A:
undetectable		 4obwC-5n13A:
14.79