SIMILAR PATTERNS OF AMINO ACIDS FOR 4OBW_B_SAMB601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfc PROTEIN
(SYNAPTOBREVIN 2)
PROTEIN (SYNTAXIN
1A)

(Rattus
norvegicus;
Rattus
norvegicus) 		PF00957
(Synaptobrevin)
PF00804
(Syntaxin)
PF05739
(SNARE) 		4 LYS B 204
ASP A  44
ASN A  49
SER B 208
 None
 1.48A 4obwB-1sfcB:
undetectable		 4obwB-1sfcB:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2my7 CUGBP ELAV-LIKE
FAMILY MEMBER 2

(Homo sapiens) 		PF00076
(RRM_1) 		4 LYS A 484
ASP A 439
ASN A 443
SER A 487
 None
 1.46A 4obwB-2my7A:
undetectable		 4obwB-2my7A:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01209
(Ubie_methyltran) 		4 LYS A  94
ASP A 148
ASN A 179
SER A 197
 SAM  A 602 (-3.3A)
SAM  A 602 (-2.9A)
SAM  A 602 (-3.7A)
SAM  A 602 (-2.9A)
 0.27A 4obwB-4obwA:
39.2		 4obwB-4obwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF12157
(DUF3591)
PF04658
(TAFII55_N) 		4 LYS A 507
ASP B 137
ASN B 131
SER B 142
 None
 1.11A 4obwB-4oy2A:
0.0		 4obwB-4oy2A:
20.19