SIMILAR PATTERNS OF AMINO ACIDS FOR 4OBW_A_SAMA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		3 ASP A 214
ASN A 139
SER A 265
 None
 0.82A 4obwA-1b1yA:
undetectable		 4obwA-1b1yA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b43 PROTEIN (FEN-1)

(Pyrococcus
furiosus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 ASP A 235
ASN A 237
SER A 175
 None
 0.86A 4obwA-1b43A:
undetectable		 4obwA-1b43A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d3b PROTEIN (SMALL
NUCLEAR
RIBONUCLEOPROTEIN SM
D3)
PROTEIN (SMALL
NUCLEAR
RIBONUCLEOPROTEIN
ASSOCIATED PROTEIN
B)

(Homo sapiens;
Homo sapiens) 		PF01423
(LSM)
PF01423
(LSM) 		3 ASP B  23
ASN A  23
SER B  79
 GOL  B 608 ( 2.9A)
GOL  B 608 (-3.4A)
None
 0.75A 4obwA-1d3bB:
undetectable		 4obwA-1d3bB:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbh PROTEIN (HUMAN SOS
1)

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		3 ASP A 241
ASN A 233
SER A 313
 None
 0.53A 4obwA-1dbhA:
undetectable		 4obwA-1dbhA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtp DIPHTHERIA TOXIN

(Corynephage
beta) 		PF02763
(Diphtheria_C) 		3 ASP A  49
ASN A  98
SER A 109
 None
 0.74A 4obwA-1dtpA:
undetectable		 4obwA-1dtpA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		3 ASP A 408
ASN A 103
SER A  81
 None
ONL  A 505 (-4.4A)
None
 0.46A 4obwA-1ecgA:
4.4		 4obwA-1ecgA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee2 ALCOHOL
DEHYDROGENASE

(Equus caballus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A 226
ASN A 241
SER A 363
 None
 0.77A 4obwA-1ee2A:
7.5		 4obwA-1ee2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei6 PHOSPHONOACETATE
HYDROLASE

(Pseudomonas
fluorescens) 		PF01663
(Phosphodiest) 		3 ASP A 397
ASN A 404
SER A  70
 None
 0.81A 4obwA-1ei6A:
undetectable		 4obwA-1ei6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fob BETA-1,4-GALACTANASE

(Aspergillus
aculeatus) 		PF07745
(Glyco_hydro_53) 		3 ASP A 187
ASN A 233
SER A 221
 None
 0.74A 4obwA-1fobA:
undetectable		 4obwA-1fobA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjq BETA-1,4-GALACTANASE

(Humicola
insolens) 		PF07745
(Glyco_hydro_53) 		3 ASP A 186
ASN A 232
SER A 220
 None
 0.85A 4obwA-1hjqA:
undetectable		 4obwA-1hjqA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjq BETA-1,4-GALACTANASE

(Humicola
insolens) 		PF07745
(Glyco_hydro_53) 		3 ASP A 224
ASN A 231
SER A 279
 None
 0.71A 4obwA-1hjqA:
undetectable		 4obwA-1hjqA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igr INSULIN-LIKE GROWTH
FACTOR RECEPTOR 1

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		3 ASP A 405
ASN A 408
SER A 427
 None
 0.81A 4obwA-1igrA:
undetectable		 4obwA-1igrA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9l STATIONARY PHASE
SURVIVAL PROTEIN

(Thermotoga
maritima) 		PF01975
(SurE) 		3 ASP A  73
ASN A  80
SER A 111
 None
 0.86A 4obwA-1j9lA:
2.2		 4obwA-1j9lA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		3 ASP A 429
ASN A 471
SER A 422
 None
 0.79A 4obwA-1mqqA:
2.0		 4obwA-1mqqA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7u ADSORPTION PROTEIN
P2

(Salmonella
virus PRD1) 		PF09214
(Prd1-P2) 		3 ASP A 132
ASN A 142
SER A  62
 None
 0.76A 4obwA-1n7uA:
undetectable		 4obwA-1n7uA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		3 ASP A 184
ASN A 228
SER A 378
 CA  A 601 (-2.3A)
None
None
 0.85A 4obwA-1ot5A:
2.2		 4obwA-1ot5A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3w CYSTEINE DESULFURASE

(Escherichia
coli) 		no annotation 3 ASP B 180
ASN B  80
SER B 100
 PLP  B 764 (-2.8A)
None
None
 0.83A 4obwA-1p3wB:
4.3		 4obwA-1p3wB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ASP A 654
ASN A 707
SER A 657
 None
 0.84A 4obwA-1po0A:
undetectable		 4obwA-1po0A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqs CELL DIVISION
CONTROL PROTEIN 24

(Saccharomyces
cerevisiae) 		PF00564
(PB1) 		3 ASP A 792
ASN A 799
SER A 830
 None
 0.71A 4obwA-1pqsA:
undetectable		 4obwA-1pqsA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0p COMPLEMENT FACTOR B

(Homo sapiens) 		PF00092
(VWA) 		3 ASP A 251
ASN A 260
SER A 326
 MN  A 500 ( 4.0A)
None
None
 0.73A 4obwA-1q0pA:
undetectable		 4obwA-1q0pA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		3 ASP A 283
ASN A 280
SER A 353
 None
 0.81A 4obwA-1qhoA:
undetectable		 4obwA-1qhoA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		3 ASP A 528
ASN A 521
SER A 291
 None
 0.86A 4obwA-1qleA:
undetectable		 4obwA-1qleA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rmg RHAMNOGALACTURONASE
A

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		3 ASP A 279
ASN A 247
SER A 254
 None
 0.66A 4obwA-1rmgA:
undetectable		 4obwA-1rmgA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2z HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Saccharomyces
cerevisiae) 		PF08123
(DOT1) 		3 ASP A 397
ASN A 404
SER A 455
 SAH  A 801 (-3.0A)
SAH  A 801 ( 4.9A)
None
 0.77A 4obwA-1u2zA:
9.3		 4obwA-1u2zA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udq RIBONUCLEASE PH

(Aquifex
aeolicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		3 ASP A 174
ASN A 188
SER A  31
 None
PO4  A 701 ( 4.8A)
None
 0.83A 4obwA-1udqA:
undetectable		 4obwA-1udqA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		3 ASP A 661
ASN A 612
SER A 305
 None
 0.58A 4obwA-1uf2A:
undetectable		 4obwA-1uf2A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		3 ASP A 300
ASN A 358
SER A 392
 None
 0.67A 4obwA-1ukcA:
undetectable		 4obwA-1ukcA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		3 ASP A 433
ASN A  46
SER A 437
 None
 0.80A 4obwA-1vg0A:
undetectable		 4obwA-1vg0A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Bacillus
subtilis) 		PF02504
(FA_synthesis) 		3 ASP A 139
ASN A 229
SER A 283
 None
 0.85A 4obwA-1vi1A:
2.7		 4obwA-1vi1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 ASP A 415
ASN A 474
SER A  50
 None
 0.87A 4obwA-1w1kA:
undetectable		 4obwA-1w1kA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		3 ASP A 241
ASN A 233
SER A 313
 None
 0.52A 4obwA-1xdvA:
undetectable		 4obwA-1xdvA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)

(Homo sapiens) 		PF01834
(XRCC1_N) 		3 ASP A  63
ASN A  23
SER A 140
 None
 0.76A 4obwA-1xntA:
undetectable		 4obwA-1xntA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		3 ASP A 290
ASN A 411
SER A 344
 None
 0.80A 4obwA-1ybeA:
undetectable		 4obwA-1ybeA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Actinobacillus
succinogenes) 		PF01293
(PEPCK_ATP) 		3 ASP A  93
ASN A 186
SER A  86
 None
 0.81A 4obwA-1yggA:
undetectable		 4obwA-1yggA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvm TOXIN B

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		3 ASP A 109
ASN A 116
SER A 228
 None
 0.77A 4obwA-2bvmA:
undetectable		 4obwA-2bvmA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		3 ASP A 138
ASN A  29
SER A 142
 None
 0.86A 4obwA-2dulA:
12.8		 4obwA-2dulA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e47 TIME INTERVAL
MEASURING ENZYME
TIME

(Bombyx mori) 		PF00080
(Sod_Cu) 		3 ASP A  87
ASN A  90
SER A  66
 ZN  A 172 (-2.4A)
None
None
 0.75A 4obwA-2e47A:
undetectable		 4obwA-2e47A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6a COLLAGEN ADHESIN

(Staphylococcus
aureus) 		PF05737
(Collagen_bind) 		3 ASP A  40
ASN A 155
SER A 126
 None
 0.84A 4obwA-2f6aA:
undetectable		 4obwA-2f6aA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		3 ASP B 337
ASN B 449
SER B 400
 None
 0.69A 4obwA-2fffB:
undetectable		 4obwA-2fffB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		3 ASP B 337
ASN B 449
SER B 404
 None
 0.79A 4obwA-2fffB:
undetectable		 4obwA-2fffB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A 226
ASN A 241
SER A 363
 None
 0.85A 4obwA-2fzwA:
6.8		 4obwA-2fzwA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf2 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Homo sapiens) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		3 ASP A 285
ASN A 212
SER A 133
 None
 0.82A 4obwA-2gf2A:
3.0		 4obwA-2gf2A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		3 ASP A 232
ASN A 230
SER A 126
 None
 0.80A 4obwA-2h4tA:
undetectable		 4obwA-2h4tA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i54 PHOSPHOMANNOMUTASE

(Leishmania
mexicana) 		PF03332
(PMM) 		3 ASP A  10
ASN A  70
SER A 210
 MG  A2002 (-2.8A)
None
None
 0.78A 4obwA-2i54A:
undetectable		 4obwA-2i54A:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 ASP A 484
ASN A 437
SER A 810
 None
 0.83A 4obwA-2inyA:
undetectable		 4obwA-2inyA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqj STROMAL
MEMBRANE-ASSOCIATED
PROTEIN 1-LIKE

(Homo sapiens) 		PF01412
(ArfGap) 		3 ASP A  71
ASN A  69
SER A  40
 None
 0.84A 4obwA-2iqjA:
undetectable		 4obwA-2iqjA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iye COPPER-TRANSPORTING
ATPASE

(Sulfolobus
solfataricus) 		PF00702
(Hydrolase) 		3 ASP A 546
ASN A 563
SER A 516
 None
 0.75A 4obwA-2iyeA:
3.3		 4obwA-2iyeA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		3 ASP A 329
ASN A 133
SER A  75
 ERY  A1400 (-4.7A)
ERY  A1400 (-3.6A)
None
 0.85A 4obwA-2iyfA:
4.0		 4obwA-2iyfA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		3 ASP A 200
ASN A 193
SER A 601
 None
 0.87A 4obwA-2j0jA:
undetectable		 4obwA-2j0jA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbe ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		3 ASP A 239
ASN A 243
SER A 138
 None
 0.84A 4obwA-2kbeA:
3.8		 4obwA-2kbeA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lcu BC28.1

(Babesia canis) 		no annotation 3 ASP A 148
ASN A 144
SER A 135
 None
 0.80A 4obwA-2lcuA:
undetectable		 4obwA-2lcuA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ASP A 137
ASN A 134
SER A 777
 None
 0.83A 4obwA-2nyaA:
3.2		 4obwA-2nyaA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o57 PUTATIVE SARCOSINE
DIMETHYLGLYCINE
METHYLTRANSFERASE

(Galdieria
sulphuraria) 		PF08241
(Methyltransf_11) 		3 ASP A  31
ASN A 267
SER A 258
 None
 0.77A 4obwA-2o57A:
17.1		 4obwA-2o57A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 3 ASP A 276
ASN A 255
SER A 367
 CA  A 620 (-2.1A)
None
None
 0.81A 4obwA-2quaA:
3.2		 4obwA-2quaA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7y RIBONUCLEASE H

(Bacillus
halodurans) 		no annotation 3 ASP A 163
ASN A 170
SER A 147
 None
 0.87A 4obwA-2r7yA:
undetectable		 4obwA-2r7yA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4x CAPSID PROTEIN P27

(Jaagsiekte
sheep
retrovirus) 		PF00607
(Gag_p24) 		3 ASP A 106
ASN A 110
SER A  13
 None
 0.81A 4obwA-2v4xA:
undetectable		 4obwA-2v4xA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjh PHYCOERYTHRIN BETA
SUBUNIT

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		3 ASP B  54
ASN B  47
SER B 132
 PUB  B1050 (-3.0A)
None
None
 0.86A 4obwA-2vjhB:
undetectable		 4obwA-2vjhB:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		3 ASP A 109
ASN A 116
SER A 228
 None
 0.85A 4obwA-2vl8A:
undetectable		 4obwA-2vl8A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w38 SIALIDASE

(Pseudomonas
aeruginosa) 		PF13088
(BNR_2) 		3 ASP A  79
ASN A 181
SER A 299
 None
 0.82A 4obwA-2w38A:
undetectable		 4obwA-2w38A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 ASP A  43
ASN A  45
SER A  35
 None
NAG  A1614 (-1.9A)
None
 0.85A 4obwA-2xydA:
undetectable		 4obwA-2xydA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7b ACTIN-BINDING
PROTEIN ANILLIN

(Homo sapiens) 		PF00169
(PH) 		3 ASP A1096
ASN A1103
SER A1088
 None
 0.72A 4obwA-2y7bA:
undetectable		 4obwA-2y7bA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9c TRANSLATION
INITIATION FACTOR
EIF-2B, DELTA
SUBUNIT

(Thermococcus
kodakarensis) 		PF01008
(IF-2B) 		3 ASP A  89
ASN A  44
SER A  86
 None
 0.87A 4obwA-3a9cA:
5.9		 4obwA-3a9cA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		3 ASP A 422
ASN A 489
SER A 418
 None
 0.87A 4obwA-3actA:
undetectable		 4obwA-3actA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		3 ASP A 230
ASN A 266
SER A 223
 None
 0.73A 4obwA-3afgA:
2.1		 4obwA-3afgA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aj6 MAIN HEMAGGLUTININ
COMPONENT

(Clostridium
botulinum) 		no annotation 3 ASP A 271
ASN A 215
SER A 260
 None
 0.75A 4obwA-3aj6A:
undetectable		 4obwA-3aj6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II

(Streptomyces
avermitilis) 		PF04616
(Glyco_hydro_43)
PF05270
(AbfB) 		3 ASP A 135
ASN A 195
SER A 262
 GOL  A 591 (-3.0A)
None
None
 0.74A 4obwA-3akfA:
undetectable		 4obwA-3akfA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145

(Methanococcus
maripaludis) 		PF01968
(Hydantoinase_A) 		3 ASP A 140
ASN A 266
SER A 136
 None
 0.80A 4obwA-3c0bA:
undetectable		 4obwA-3c0bA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnc FIBER PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		3 ASP A 283
ASN A 321
SER A 266
 None
 0.83A 4obwA-3cncA:
undetectable		 4obwA-3cncA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czm L-LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ASP A 111
ASN A 140
SER A 103
 None
OXQ  A 708 ( 3.4A)
None
 0.83A 4obwA-3czmA:
4.8		 4obwA-3czmA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d43 SPHERICASE

(Lysinibacillus
sphaericus) 		PF00082
(Peptidase_S8) 		3 ASP A  67
ASN A 240
SER A 108
 None
 0.55A 4obwA-3d43A:
undetectable		 4obwA-3d43A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		3 ASP A  61
ASN A  57
SER A  94
 None
 0.67A 4obwA-3fdhA:
undetectable		 4obwA-3fdhA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASP A 405
ASN A 338
SER A 375
 None
MG  A 901 ( 2.8A)
None
 0.82A 4obwA-3g2fA:
undetectable		 4obwA-3g2fA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 ASP A 398
ASN A 395
SER A 451
 MG  A 601 (-2.8A)
None
None
 0.79A 4obwA-3hztA:
undetectable		 4obwA-3hztA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		3 ASP A 433
ASN A 435
SER A 485
 None
 0.71A 4obwA-3i6rA:
undetectable		 4obwA-3i6rA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imh GALACTOSE-1-EPIMERAS
E

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		3 ASP A 292
ASN A 280
SER A  51
 MG  A 337 ( 4.0A)
None
None
 0.83A 4obwA-3imhA:
undetectable		 4obwA-3imhA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B

(Francisella
tularensis) 		PF05943
(VipB) 		3 ASP B 276
ASN B 261
SER B 282
 None
 0.68A 4obwA-3j9oB:
undetectable		 4obwA-3j9oB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmh D-LYXOSE ISOMERASE

(Escherichia
coli) 		PF07385
(Lyx_isomer) 		3 ASP A 194
ASN A 197
SER A  77
 None
 0.74A 4obwA-3kmhA:
undetectable		 4obwA-3kmhA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksy SON OF SEVENLESS
HOMOLOG 1

(Homo sapiens) 		PF00125
(Histone)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		3 ASP A 241
ASN A 233
SER A 313
 None
 0.86A 4obwA-3ksyA:
undetectable		 4obwA-3ksyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxf SB27 T CELL RECEPTOR
ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 ASP D 153
ASN D 192
SER D 183
 None
 0.77A 4obwA-3kxfD:
undetectable		 4obwA-3kxfD:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE

(Methanocaldococcus
jannaschii) 		PF02277
(DBI_PRT) 		3 ASP A 111
ASN A 125
SER A  28
 None
 0.87A 4obwA-3l0zA:
undetectable		 4obwA-3l0zA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5

(Homo sapiens) 		PF01094
(ANF_receptor) 		3 ASP A 309
ASN A 483
SER A 304
 None
 0.70A 4obwA-3lmkA:
2.8		 4obwA-3lmkA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1

(Saccharomyces
cerevisiae) 		PF16499
(Melibiase_2) 		3 ASP A 149
ASN A 153
SER A 207
 GOL  A7001 (-4.1A)
None
None
 0.71A 4obwA-3lrkA:
undetectable		 4obwA-3lrkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mue PANTOTHENATE
SYNTHETASE

(Salmonella
enterica) 		PF02569
(Pantoate_ligase) 		3 ASP A 276
ASN A 206
SER A 279
 None
 0.75A 4obwA-3mueA:
undetectable		 4obwA-3mueA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhe UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2

(Homo sapiens) 		PF00443
(UCH) 		3 ASP A 392
ASN A 535
SER A 421
 None
 0.86A 4obwA-3nheA:
undetectable		 4obwA-3nheA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ASP A 146
ASN A 143
SER A 787
 None
None
OCS  A 784 ( 3.2A)
 0.76A 4obwA-3o5aA:
3.6		 4obwA-3o5aA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of1 CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT

(Saccharomyces
cerevisiae) 		PF00027
(cNMP_binding) 		3 ASP A 364
ASN A 411
SER A 299
 None
 0.66A 4obwA-3of1A:
undetectable		 4obwA-3of1A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om9 LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ASP A 111
ASN A 140
SER A 105
 None
OXQ  A 702 ( 3.2A)
None
 0.47A 4obwA-3om9A:
3.8		 4obwA-3om9A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8a UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF13468
(Glyoxalase_3) 		3 ASP A 160
ASN A 109
SER A 206
 None
 0.83A 4obwA-3p8aA:
undetectable		 4obwA-3p8aA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		3 ASP A 330
ASN A 337
SER A  66
 None
 0.77A 4obwA-3p9uA:
2.7		 4obwA-3p9uA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg8 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		3 ASP A 269
ASN A 248
SER A 313
 None
 0.75A 4obwA-3pg8A:
undetectable		 4obwA-3pg8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		3 ASP A 247
ASN A 174
SER A  95
 NAD  A 299 (-3.8A)
None
None
 0.81A 4obwA-3q3cA:
5.1		 4obwA-3q3cA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlb ENANTIO-PYOCHELIN
RECEPTOR

(Pseudomonas
fluorescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ASP A 362
ASN A 343
SER A 138
 None
 0.58A 4obwA-3qlbA:
undetectable		 4obwA-3qlbA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rdn ANTIFREEZE PROTEIN
RD3 TYPE III

(Lycodichthys
dearborni) 		no annotation 3 ASP A  58
ASN A  46
SER A  69
 None
 0.84A 4obwA-3rdnA:
undetectable		 4obwA-3rdnA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE

(Wolinella
succinogenes) 		PF01053
(Cys_Met_Meta_PP) 		3 ASP A 180
ASN A 155
SER A 203
 None
 0.74A 4obwA-3ri6A:
3.0		 4obwA-3ri6A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rof LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE PTPA

(Staphylococcus
aureus) 		PF01451
(LMWPc) 		3 ASP A 120
ASN A 125
SER A  15
 PO4  A 201 (-2.8A)
None
None
 0.84A 4obwA-3rofA:
3.7		 4obwA-3rofA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3saj GLUTAMATE RECEPTOR 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 ASP A 185
ASN A 158
SER A 188
 None
 0.78A 4obwA-3sajA:
4.0		 4obwA-3sajA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sns LIPOPROTEIN 34

(Escherichia
coli) 		PF06804
(Lipoprotein_18) 		3 ASP A 229
ASN A 312
SER A 232
 None
 0.87A 4obwA-3snsA:
undetectable		 4obwA-3snsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		3 ASP A 294
ASN A 121
SER A  96
 None
 0.81A 4obwA-3u95A:
4.0		 4obwA-3u95A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugg SUCROSE:(SUCROSE/FRU
CTAN)
6-FRUCTOSYLTRANSFERA
SE

(Pachysandra
terminalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 ASP A 451
ASN A 521
SER A 421
 None
NAG  A 553 (-1.8A)
None
 0.84A 4obwA-3uggA:
undetectable		 4obwA-3uggA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ASP A 849
ASN A 867
SER A 956
 None
 0.87A 4obwA-3va7A:
3.3		 4obwA-3va7A:
11.50