SIMILAR PATTERNS OF AMINO ACIDS FOR 4OBW_A_SAMA602_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aor | ALDEHYDE FERREDOXINOXIDOREDUCTASE (Pyrococcusfuriosus) |
PF01314(AFOR_C)PF02730(AFOR_N) | 5 | ALA A 174GLY A 188SER A 83ILE A 163GLY A 341 | None | 1.24A | 4obwA-1aorA:undetectable | 4obwA-1aorA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bxz | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 242GLY A 174ILE A 240GLY A 155ASN A 264 | None | 1.15A | 4obwA-1bxzA:7.8 | 4obwA-1bxzA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hzv | NITRITE REDUCTASE (Pseudomonasaeruginosa) |
PF02239(Cytochrom_D1)PF13442(Cytochrome_CBB3) | 5 | ALA A 200GLY A 221ILE A 202MET A 124GLY A 197 | None | 1.24A | 4obwA-1hzvA:undetectable | 4obwA-1hzvA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ig0 | THIAMINPYROPHOSPHOKINASE (Saccharomycescerevisiae) |
PF04263(TPK_catalytic)PF04265(TPK_B1_binding) | 5 | TYR A 109ALA A 71GLY A 70ILE A 48GLY A 190 | None | 1.02A | 4obwA-1ig0A:2.3 | 4obwA-1ig0A:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kb0 | QUINOHEMOPROTEINALCOHOLDEHYDROGENASE (Comamonastestosteroni) |
PF13360(PQQ_2)PF13442(Cytochrome_CBB3) | 5 | ASN A 427ALA A 184GLY A 183SER A 163GLY A 262 | NonePQQ A1800 (-3.2A)PQQ A1800 (-3.7A)NoneNone | 1.22A | 4obwA-1kb0A:undetectable | 4obwA-1kb0A:16.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lnl | HEMOCYANIN (Rapana venosa) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | ALA A 186GLY A 189SER A 195ILE A 184ASN A 182 | None | 1.25A | 4obwA-1lnlA:undetectable | 4obwA-1lnlA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mg5 | ALCOHOLDEHYDROGENASE (Drosophilamelanogaster) |
PF00106(adh_short) | 5 | ALA A 13GLY A 14SER A 23GLY A 94ASN A 91 | NAI A 850 (-3.2A)NoneNoneNAI A 850 (-3.5A)None | 1.04A | 4obwA-1mg5A:6.2 | 4obwA-1mg5A:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nff | PUTATIVEOXIDOREDUCTASERV2002 (Mycobacteriumtuberculosis) |
PF13561(adh_short_C2) | 5 | ALA A 168GLY A 229SER A 180ILE A 176GLY A 172 | None | 1.23A | 4obwA-1nffA:7.2 | 4obwA-1nffA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8f | PYRIMIDINENUCLEOSIDE HYDROLASE (Escherichiacoli) |
PF01156(IU_nuc_hydro) | 5 | ALA A 153GLY A 188ILE A 167ASN A 166MET A 150 | NoneNoneNoneGOL A3001 (-3.3A)GOL A3001 (-3.4A) | 1.22A | 4obwA-1q8fA:3.4 | 4obwA-1q8fA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rdr | POLIOVIRUS 3DPOLYMERASE (Enterovirus C) |
PF00680(RdRP_1) | 5 | ASN A 18ALA A 209SER A 294GLY A 203PHE A 217 | None | 1.08A | 4obwA-1rdrA:undetectable | 4obwA-1rdrA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v3t | LEUKOTRIENE B412-HYDROXYDEHYDROGENASE/PROSTAGLANDIN15-KETO REDUCTASE (Cavia porcellus) |
PF00107(ADH_zinc_N)PF16884(ADH_N_2) | 5 | TYR A 214ALA A 172GLY A 171ASN A 217GLY A 174 | NoneNoneNoneNAP A1350 (-3.9A)NAP A1350 (-3.2A) | 0.89A | 4obwA-1v3tA:7.2 | 4obwA-1v3tA:24.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ve3 | HYPOTHETICAL PROTEINPH0226 (Pyrococcushorikoshii) |
PF13649(Methyltransf_25) | 5 | TYR A 7ALA A 46ILE A 68MET A 72PHE A 116 | SAM A 302 (-4.6A)SAM A 302 (-3.4A)SAM A 302 (-3.7A)SAM A 302 (-3.9A)SAM A 302 (-4.4A) | 1.16A | 4obwA-1ve3A:7.6 | 4obwA-1ve3A:24.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xc6 | BETA-GALACTOSIDASE (Penicillium sp.) |
PF01301(Glyco_hydro_35)PF10435(BetaGal_dom2)PF13363(BetaGal_dom3)PF13364(BetaGal_dom4_5) | 5 | TYR A 363ALA A 304SER A 367MET A 344GLY A 264 | NoneNoneNoneNoneIOD A9050 ( 3.8A) | 1.23A | 4obwA-1xc6A:undetectable | 4obwA-1xc6A:13.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3v | CELLULASE (Phanerochaetechrysosporium) |
PF00840(Glyco_hydro_7) | 5 | TYR A 51ASN A 49ASN A 37GLY A 102ASN A 195 | None | 1.21A | 4obwA-1z3vA:undetectable | 4obwA-1z3vA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z9n | SUPEROXIDE DISMUTASE[CU-ZN] ([Haemophilus]ducreyi) |
PF00080(Sod_Cu) | 5 | GLY A 174SER A 147MET A 149GLY A 42ASN A 38 | None | 1.13A | 4obwA-1z9nA:undetectable | 4obwA-1z9nA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z9p | SUPEROXIDE DISMUTASE[CU-ZN] ([Haemophilus]ducreyi) |
PF00080(Sod_Cu) | 5 | GLY A 174SER A 147MET A 149GLY A 42ASN A 38 | None | 1.18A | 4obwA-1z9pA:undetectable | 4obwA-1z9pA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aqt | SUPEROXIDE DISMUTASE[CU-ZN] (Neisseriameningitidis) |
no annotation | 5 | GLY C 183SER C 156MET C 158GLY C 51ASN C 47 | None | 1.19A | 4obwA-2aqtC:undetectable | 4obwA-2aqtC:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2et6 | (3R)-HYDROXYACYL-COADEHYDROGENASE (Candidatropicalis) |
PF00106(adh_short) | 5 | ALA A 472GLY A 457SER A 456ILE A 474GLY A 476 | None | 1.09A | 4obwA-2et6A:5.4 | 4obwA-2et6A:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gp4 | 6-PHOSPHOGLUCONATEDEHYDRATASE (Shewanellaoneidensis) |
PF00920(ILVD_EDD) | 5 | ALA A 314GLY A 315SER A 16ASN A 283GLY A 169 | None | 1.05A | 4obwA-2gp4A:undetectable | 4obwA-2gp4A:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ibu | ACETYL-COAACETYLTRANSFERASE (Homo sapiens) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA A 392GLY A 129SER A 128ASN A 353GLY A 396 | NoneNoneCSO A 126 ( 4.8A)NoneNone | 1.13A | 4obwA-2ibuA:undetectable | 4obwA-2ibuA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ibu | ACETYL-COAACETYLTRANSFERASE (Homo sapiens) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA A 392GLY A 129SER A 128ILE A 394GLY A 396 | NoneNoneCSO A 126 ( 4.8A)NoneNone | 1.13A | 4obwA-2ibuA:undetectable | 4obwA-2ibuA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jks | BRADYZOITE SURFACEANTIGEN BSR4 (Toxoplasmagondii) |
PF04092(SAG) | 5 | GLY A 206SER A 204ILE A 200ASN A 201GLY A 274 | None ZN A1320 ( 4.9A)NoneNoneNone | 1.18A | 4obwA-2jksA:undetectable | 4obwA-2jksA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m4l | PROTEIN BT_0846 (Bacteroidesthetaiotaomicron) |
no annotation | 5 | GLY A 14SER A 28ILE A 79GLY A 81ASN A 10 | None | 1.05A | 4obwA-2m4lA:undetectable | 4obwA-2m4lA:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mvb | UNCHARACTERIZEDPROTEIN (Streptococcuspneumoniae) |
no annotation | 5 | TYR A 153ASN A 148GLY A 141ILE A 58PHE A 121 | None | 1.17A | 4obwA-2mvbA:undetectable | 4obwA-2mvbA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2obe | HEXON (HumanmastadenovirusE) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 5 | ASN A 306GLY A 309ILE A 572GLY A 316ASN A 570 | None | 1.20A | 4obwA-2obeA:undetectable | 4obwA-2obeA:13.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2paj | PUTATIVECYTOSINE/GUANINEDEAMINASE (unidentified) |
PF01979(Amidohydro_1) | 5 | ALA A 392GLY A 393SER A 332ILE A 387GLY A 24 | None | 1.21A | 4obwA-2pajA:3.2 | 4obwA-2pajA:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vtc | CEL61B (Trichodermareesei) |
PF03443(Glyco_hydro_61) | 5 | ALA A 167GLY A 172GLY A 208ASN A 212PHE A 211 | None | 1.20A | 4obwA-2vtcA:undetectable | 4obwA-2vtcA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y05 | PROSTAGLANDINREDUCTASE 1 (Homo sapiens) |
PF00107(ADH_zinc_N)PF16884(ADH_N_2) | 5 | TYR A 214ALA A 172GLY A 171ASN A 217GLY A 174 | NoneNoneNoneNAP A 701 (-3.8A)NAP A 701 (-3.3A) | 0.99A | 4obwA-2y05A:7.9 | 4obwA-2y05A:25.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ylz | PHENYLACETONEMONOOXYGENASE (Thermobifidafusca) |
PF13738(Pyr_redox_3) | 5 | ASN A 58GLY A 198SER A 196ILE A 192GLY A 190 | FAD A 700 (-4.2A)NoneSO4 A1543 (-4.6A)NoneNone | 1.06A | 4obwA-2ylzA:undetectable | 4obwA-2ylzA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cj1 | ECTONUCLEOSIDETRIPHOSPHATEDIPHOSPHOHYDROLASE 2 (Rattusnorvegicus) |
PF01150(GDA1_CD39) | 5 | ALA A 123GLY A 124SER A 83ASN A 129GLY A 162 | None | 0.96A | 4obwA-3cj1A:undetectable | 4obwA-3cj1A:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clk | TRANSCRIPTIONREGULATOR (Lactobacillusplantarum) |
PF13377(Peripla_BP_3) | 5 | ALA A 184GLY A 185ILE A 216GLY A 182PHE A 233 | None | 1.04A | 4obwA-3clkA:2.9 | 4obwA-3clkA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3a | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF01301(Glyco_hydro_35) | 5 | ASN A 216ALA A 185GLY A 184GLY A 474PHE A 473 | None | 1.18A | 4obwA-3d3aA:undetectable | 4obwA-3d3aA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eo3 | BIFUNCTIONALUDP-N-ACETYLGLUCOSAMINE2-EPIMERASE/N-ACETYLMANNOSAMINE KINASE (Homo sapiens) |
PF00480(ROK) | 5 | ASN A 516ALA A 524GLY A 708MET A 712GLY A 529 | None | 1.22A | 4obwA-3eo3A:undetectable | 4obwA-3eo3A:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fpl | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Clostridiumbeijerinckii;Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 242GLY A 174ILE A 240GLY A 155ASN A 264 | None | 1.24A | 4obwA-3fplA:7.7 | 4obwA-3fplA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7s | LONG-CHAIN-FATTY-ACID--COA LIGASE(FADD-1) (Archaeoglobusfulgidus) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | ASN A 84ALA A 232GLY A 235ILE A 332GLY A 334 | None | 1.26A | 4obwA-3g7sA:undetectable | 4obwA-3g7sA:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hid | ADENYLOSUCCINATESYNTHETASE (Yersinia pestis) |
PF00709(Adenylsucc_synt) | 5 | ASN A 39ALA A 137GLY A 135SER A 241GLY A 146 | None | 1.15A | 4obwA-3hidA:2.2 | 4obwA-3hidA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjr | EXTRACELLULAR SERINEPROTEASE (Aeromonassobria) |
PF00082(Peptidase_S8)PF01483(P_proprotein) | 5 | ALA A 453GLY A 456SER A 385ASN A 556GLY A 583 | None | 1.18A | 4obwA-3hjrA:undetectable | 4obwA-3hjrA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrd | NICOTINATEDEHYDROGENASE MEDIUMMOLYBDOPTERINSUBUNIT (Eubacteriumbarkeri) |
PF02738(Ald_Xan_dh_C2) | 5 | ALA B 25GLY B 160ILE B 92ASN B 95GLY B 81 | None | 1.22A | 4obwA-3hrdB:undetectable | 4obwA-3hrdB:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i9v | NADH-QUINONEOXIDOREDUCTASESUBUNIT 1 (Thermusthermophilus) |
PF01512(Complex1_51K)PF10531(SLBB)PF10589(NADH_4Fe-4S) | 5 | ASN 1 343GLY 1 99SER 1 295ILE 1 254GLY 1 262 | NoneFES 2 182 ( 4.8A)NoneNoneNone | 0.99A | 4obwA-3i9v1:2.6 | 4obwA-3i9v1:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR CWF17 (Schizosaccharomycespombe) |
PF00400(WD40) | 5 | ASN L 85GLY L 68SER L 67GLY L 94ASN L 90 | None | 1.25A | 4obwA-3jb9L:undetectable | 4obwA-3jb9L:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khk | TYPE IRESTRICTION-MODIFICATION SYSTEMMETHYLATION SUBUNIT (Methanosarcinamazei) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 5 | TYR A 226ASN A 432GLY A 253SER A 254ASN A 291 | None | 1.23A | 4obwA-3khkA:11.8 | 4obwA-3khkA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khp | MAOC FAMILY PROTEIN (Mycobacteriumtuberculosis) |
PF01575(MaoC_dehydratas)PF13452(MaoC_dehydrat_N) | 5 | ALA A 67GLY A 65GLY A 71ASN A 74PHE A 73 | None | 0.99A | 4obwA-3khpA:undetectable | 4obwA-3khpA:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l8k | DIHYDROLIPOYLDEHYDROGENASE (Sulfolobussolfataricus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ALA A 13GLY A 305ILE A 135MET A 294GLY A 9 | ADP A 465 (-3.2A)ADP A 465 (-3.3A)NoneNoneADP A 465 (-3.4A) | 1.26A | 4obwA-3l8kA:2.6 | 4obwA-3l8kA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lpd | ACIDIC EXTRACELLULARSUBTILISIN-LIKEPROTEASE APRV2 (Dichelobacternodosus) |
PF00082(Peptidase_S8) | 5 | ALA A 124GLY A 125ASN A 53GLY A 122ASN A 118 | NoneNoneNone CA A 1 ( 4.3A)None | 1.14A | 4obwA-3lpdA:2.5 | 4obwA-3lpdA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6i | L-ARABINITOL4-DEHYDROGENASE (Neurosporacrassa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | TYR A 309ASN A 120GLY A 171ILE A 194GLY A 192 | None | 1.22A | 4obwA-3m6iA:8.3 | 4obwA-3m6iA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mpp | BOTULINUM NEUROTOXINTYPE G (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 5 | ALA G 869SER G 883ILE G1069GLY G1071ASN G 936 | None | 1.09A | 4obwA-3mppG:undetectable | 4obwA-3mppG:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8q | SHIKIMATE5-DEHYDROGENASE IALPHA (Vibrio cholerae) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 5 | ASN B 90ALA B 250GLY B 247ILE B 266GLY B 262 | None | 1.22A | 4obwA-3o8qB:2.2 | 4obwA-3o8qB:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ovg | AMIDOHYDROLASE (Mycoplasmasynoviae) |
PF02126(PTE) | 5 | GLY A 11ILE A 94ASN A 92GLY A 150PHE A 328 | None | 1.14A | 4obwA-3ovgA:undetectable | 4obwA-3ovgA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pxn | KINESIN-LIKE PROTEINNOD (Drosophilamelanogaster) |
PF00225(Kinesin) | 5 | GLY A 252SER A 255ILE A 249ASN A 248GLY A 229 | None | 0.99A | 4obwA-3pxnA:undetectable | 4obwA-3pxnA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qvm | OLEI00960 (Oleispiraantarctica) |
PF00561(Abhydrolase_1) | 5 | TYR A 61ASN A 18ALA A 84GLY A 82ILE A 109 | None | 1.25A | 4obwA-3qvmA:3.2 | 4obwA-3qvmA:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s1s | RESTRICTIONENDONUCLEASE BPUSI (Bacilluspumilus) |
PF02384(N6_Mtase)PF15516(BpuSI_N) | 5 | ALA A 329GLY A 331SER A 332ILE A 356PHE A 447 | SAH A 900 (-3.2A)SAH A 900 (-3.2A)SAH A 900 (-2.6A)SAH A 900 (-3.8A)None | 1.20A | 4obwA-3s1sA:11.5 | 4obwA-3s1sA:14.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrb | FLAVOPROTEIN SUBUNITOF COMPLEX II (Ascaris suum) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | ASN A 252ALA A 52GLY A 50ILE A 233GLY A 445 | FAD A 702 ( 3.7A)FAD A 702 (-4.0A)FAD A 702 (-3.0A)NoneNone | 0.98A | 4obwA-3vrbA:undetectable | 4obwA-3vrbA:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vsv | XYLOSIDASE (Thermoanaerobacteriumsaccharolyticum) |
PF13229(Beta_helix) | 5 | TYR A 494ASN A 495ILE A 424ASN A 426GLY A 440 | None | 1.06A | 4obwA-3vsvA:undetectable | 4obwA-3vsvA:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wfz | LACTO-N-BIOSEPHOSPHORYLASE (Bifidobacteriumlongum) |
PF09508(Lact_bio_phlase)PF17385(LBP_M)PF17386(LBP_C) | 5 | ASN A 720GLY A 340SER A 478ILE A 394GLY A 357 | None | 1.22A | 4obwA-3wfzA:undetectable | 4obwA-3wfzA:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wtb | PUTATIVEOXIDOREDUCTASE (Gluconobacteroxydans) |
PF13561(adh_short_C2) | 5 | TYR A 135ALA A 167GLY A 232ILE A 175GLY A 171 | None | 1.11A | 4obwA-3wtbA:6.7 | 4obwA-3wtbA:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a6u | OMEGA TRANSAMINASE (Chromobacteriumviolaceum) |
PF00202(Aminotran_3) | 5 | ALA A 287GLY A 120SER A 121ILE A 262GLY A 264 | None | 1.23A | 4obwA-4a6uA:undetectable | 4obwA-4a6uA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ap3 | STEROIDMONOOXYGENASE (Rhodococcusrhodochrous) |
PF00743(FMO-like) | 5 | ASN A 63GLY A 203SER A 201ILE A 197GLY A 195 | FAD A1552 (-4.4A)NoneNAP A1553 (-2.9A)NoneNone | 1.01A | 4obwA-4ap3A:2.1 | 4obwA-4ap3A:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3i | FATTY ACIDBETA-OXIDATIONCOMPLEX BETA-CHAINFADA (Mycobacteriumtuberculosis) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA C 366GLY C 95SER C 94ASN C 327GLY C 370 | None | 1.13A | 4obwA-4b3iC:undetectable | 4obwA-4b3iC:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3i | FATTY ACIDBETA-OXIDATIONCOMPLEX BETA-CHAINFADA (Mycobacteriumtuberculosis) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA C 366GLY C 95SER C 94ILE C 368GLY C 370 | None | 1.14A | 4obwA-4b3iC:undetectable | 4obwA-4b3iC:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cql | ESTRADIOL17-BETA-DEHYDROGENASE 8 (Homo sapiens) |
PF13561(adh_short_C2) | 5 | ALA A 184GLY A 250SER A 196ILE A 192GLY A 188 | None | 1.26A | 4obwA-4cqlA:7.3 | 4obwA-4cqlA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d5r | A49 (Vaccinia virus) |
PF06489(Orthopox_A49R) | 5 | GLY A 134SER A 135ILE A 47ASN A 44ASN A 49 | None | 1.22A | 4obwA-4d5rA:undetectable | 4obwA-4d5rA:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4haq | GH7 FAMILY PROTEIN (Limnoriaquadripunctata) |
PF00840(Glyco_hydro_7) | 5 | TYR A 68ASN A 66ASN A 54GLY A 126ASN A 221 | None | 1.25A | 4obwA-4haqA:undetectable | 4obwA-4haqA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jrm | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Vibrio cholerae) |
no annotation | 5 | ASN D 170ILE D 149ASN D 146GLY D 152ASN D 157 | None | 1.23A | 4obwA-4jrmD:undetectable | 4obwA-4jrmD:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l4y | TRANSCRIPTIONALREGULATOR LSRR (Escherichiacoli) |
PF04198(Sugar-bind) | 5 | TYR A 156GLY A 125ILE A 207MET A 129GLY A 281 | None | 1.25A | 4obwA-4l4yA:5.6 | 4obwA-4l4yA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mi4 | SPERMIDINEN1-ACETYLTRANSFERASE (Vibrio cholerae) |
PF13302(Acetyltransf_3) | 5 | ALA A 90ILE A 88GLY A 69ASN A 20PHE A 17 | None | 0.96A | 4obwA-4mi4A:2.8 | 4obwA-4mi4A:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o6v | OXIDOREDUCTASE,SHORT-CHAINDEHYDROGENASE/REDUCTASE FAMILY (Brucella suis) |
PF13561(adh_short_C2) | 5 | ALA A 11SER A 55ILE A 9GLY A 17ASN A 81 | None | 1.26A | 4obwA-4o6vA:6.5 | 4obwA-4o6vA:25.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4obw | 2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOLMETHYLASE,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF01209(Ubie_methyltran) | 12 | TYR A 78ASN A 82LYS A 94ALA A 119GLY A 120SER A 122ILE A 149ASN A 150MET A 153GLY A 180ASN A 202PHE A 203 | SAM A 602 (-3.9A)SAM A 602 ( 4.2A)SAM A 602 (-3.3A)SAM A 602 (-3.2A)SAM A 602 (-3.4A)SAM A 602 (-3.1A)SAM A 602 (-3.8A)SAM A 602 (-4.9A)SAM A 602 (-3.7A)SAM A 602 (-3.5A)SAM A 602 ( 4.9A)SAM A 602 (-3.9A) | 0.04A | 4obwA-4obwA:43.8 | 4obwA-4obwA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4obw | 2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOLMETHYLASE,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF01209(Ubie_methyltran) | 7 | TYR A 78GLY A 121SER A 122ILE A 149ASN A 150GLY A 180ASN A 202 | SAM A 602 (-3.9A)NoneSAM A 602 (-3.1A)SAM A 602 (-3.8A)SAM A 602 (-4.9A)SAM A 602 (-3.5A)SAM A 602 ( 4.9A) | 1.10A | 4obwA-4obwA:43.8 | 4obwA-4obwA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oc9 | PUTATIVEO-ACETYLHOMOSERINE(THIOL)-LYASE (Campylobacterjejuni) |
PF01053(Cys_Met_Meta_PP) | 5 | ALA A 217GLY A 216SER A 82ILE A 78GLY A 65 | NoneNoneLLP A 205 ( 3.7A)NoneNone | 1.18A | 4obwA-4oc9A:3.0 | 4obwA-4oc9A:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wem | ANTI-F4+ETECBACTERIA VHHVARIABLE REGION (Lama glama) |
PF07686(V-set) | 5 | GLY B 901SER B 898ILE B 851GLY B 855ASN B 858 | None | 1.22A | 4obwA-4wemB:undetectable | 4obwA-4wemB:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wr2 | PYRIMIDINE-SPECIFICRIBONUCLEOSIDEHYDROLASE RIHA (Shewanellaloihica) |
PF01156(IU_nuc_hydro) | 5 | ALA A 199GLY A 234ILE A 213ASN A 212MET A 196 | 1PE A 402 ( 4.4A)NoneNone CA A 401 ( 4.4A)None | 1.24A | 4obwA-4wr2A:undetectable | 4obwA-4wr2A:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x0o | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 PROTEIN 2 (Vibrio cholerae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | ASN A 110GLY A 312ILE A 190GLY A 216PHE A 214 | NoneSCY A 113 ( 3.1A)NoneNoneNone | 1.20A | 4obwA-4x0oA:undetectable | 4obwA-4x0oA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x68 | BETA-LACTAMASE (Pseudomonasaeruginosa) |
PF00144(Beta-lactamase) | 5 | ALA A 367GLY A 350SER A 345GLY A 53ASN A 49 | NoneNoneOP0 A 401 (-4.6A)NoneNone | 1.10A | 4obwA-4x68A:undetectable | 4obwA-4x68A:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xn3 | TAIL SPIKE PROTEIN (Salmonellavirus HK620) |
no annotation | 5 | ASN A 315ALA A 287GLY A 289ILE A 310GLY A 285 | NAG A1004 (-3.1A)NoneNoneNoneNone | 1.25A | 4obwA-4xn3A:undetectable | 4obwA-4xn3A:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z9r | OMEGA-3POLYUNSATURATEDFATTY ACID SYNTHASESUBUNIT PFAD (Shewanellaoneidensis) |
PF03060(NMO) | 5 | LYS A 294ALA A 311GLY A 310ILE A 315GLY A 313 | NoneNoneNoneNoneFMN A 602 (-3.4A) | 0.98A | 4obwA-4z9rA:undetectable | 4obwA-4z9rA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b04 | TRANSLATIONINITIATION FACTOREIF-2B SUBUNIT ALPHA (Schizosaccharomycespombe) |
PF01008(IF-2B) | 5 | ALA A 81GLY A 82ILE A 77ASN A 76GLY A 213 | None | 1.09A | 4obwA-5b04A:2.6 | 4obwA-5b04A:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e84 | 78 KDAGLUCOSE-REGULATEDPROTEIN (Homo sapiens) |
PF00012(HSP70) | 5 | GLY A 216ILE A 220ASN A 219GLY A 210PHE A 242 | None | 1.24A | 4obwA-5e84A:undetectable | 4obwA-5e84A:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5evi | BETA-LACTAMASE/D-ALANINECARBOXYPEPTIDASE (Pseudomonassyringae groupgenomosp. 3) |
PF00144(Beta-lactamase) | 5 | ALA B 338GLY B 321SER B 316GLY B 26ASN B 22 | MLY B 340 ( 4.0A)MLY B 340 ( 3.1A)NoneNoneNone | 1.08A | 4obwA-5eviB:undetectable | 4obwA-5eviB:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ewx | ENDOLYSIN,IMMUNOGLOBULIN G-BINDINGPROTEIN A,ENDOLYSIN (Staphylococcusaureus;Escherichiavirus T4) |
PF00959(Phage_lysozyme)PF02216(B) | 5 | TYR A 161ILE A 3MET A 1ASN A 101PHE A 104 | None | 1.20A | 4obwA-5ewxA:undetectable | 4obwA-5ewxA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5exe | OXALATEOXIDOREDUCTASESUBUNIT BETA (Moorellathermoacetica) |
PF02775(TPP_enzyme_C) | 5 | ALA C 113GLY C 111SER C 149GLY C 77PHE C 133 | None5SR C 402 (-3.4A)NoneNoneNone | 1.26A | 4obwA-5exeC:2.9 | 4obwA-5exeC:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fav | CHOLINETRIMETHYLAMINE-LYASE (Desulfovibrioalaskensis) |
PF01228(Gly_radical)PF02901(PFL-like) | 5 | GLY A 726SER A 724ILE A 700ASN A 702GLY A 821 | None | 1.25A | 4obwA-5favA:undetectable | 4obwA-5favA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmg | PROTEASOME SUBUNITALPHA, PUTATIVE (Plasmodiumfalciparum) |
PF00227(Proteasome)PF10584(Proteasome_A_N) | 5 | GLY A 144SER A 143ILE A 75ASN A 74GLY A 83 | None | 1.11A | 4obwA-5fmgA:undetectable | 4obwA-5fmgA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fya | PATATIN-LIKEPROTEIN, PLPD (Pseudomonasaeruginosa) |
PF01734(Patatin) | 5 | ASN A 234GLY A 208SER A 60ILE A 168GLY A 171 | None | 1.07A | 4obwA-5fyaA:2.4 | 4obwA-5fyaA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gs7 | CHOLOYLGLYCINEHYDROLASE (Enterococcusfaecalis) |
PF02275(CBAH) | 5 | ASN A 170ALA A 76GLY A 77GLY A 74PHE A 14 | None | 1.25A | 4obwA-5gs7A:undetectable | 4obwA-5gs7A:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hzl | LMO2445 PROTEIN (Listeriamonocytogenes) |
no annotation | 5 | ALA B 155GLY B 156SER B 158ILE B 113GLY B 110 | NoneNonePG5 B 408 ( 4.2A)NoneNone | 1.26A | 4obwA-5hzlB:undetectable | 4obwA-5hzlB:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jvk | UNCHARACTERIZEDPROTEIN (Bacteroidescellulosilyticus) |
no annotation | 5 | TYR A 311ALA A 294GLY A 286SER A 285GLY A 330 | NoneNoneNoneNoneSO4 A 651 (-3.3A) | 1.20A | 4obwA-5jvkA:undetectable | 4obwA-5jvkA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lv9 | THERMOPHILICTRYPTOPHANHALOGENASE (Streptomycesviolaceusniger) |
PF04820(Trp_halogenase) | 5 | ALA A 13GLY A 349SER A 352ILE A 7GLY A 10 | None | 1.20A | 4obwA-5lv9A:4.1 | 4obwA-5lv9A:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mln | ALCOHOLDEHYDROGENASE 3 ([Candida]magnoliae) |
no annotation | 5 | TYR A 141ALA A 172GLY A 230ILE A 180GLY A 176 | None | 1.25A | 4obwA-5mlnA:6.4 | 4obwA-5mlnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sz8 | HEMOLYSIN (Proteusmirabilis) |
PF05860(Haemagg_act) | 5 | ASN A 96ALA A 92GLY A 93ASN A 47GLY A 77 | None | 1.23A | 4obwA-5sz8A:undetectable | 4obwA-5sz8A:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ti8 | AMINOTRANSFERASE (Pseudomonas sp.M1) |
PF00202(Aminotran_3) | 5 | ALA A 289GLY A 122SER A 123ILE A 264GLY A 266 | None | 1.19A | 4obwA-5ti8A:undetectable | 4obwA-5ti8A:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u9p | GLUCONATE5-DEHYDROGENASE (Burkholderiacenocepacia) |
PF13561(adh_short_C2) | 5 | TYR A 161GLY A 98ILE A 24GLY A 23ASN A 199 | TLA A 302 ( 4.0A)NAP A 301 (-3.8A)NAP A 301 (-3.9A)NAP A 301 (-3.5A)TLA A 302 ( 3.0A) | 1.17A | 4obwA-5u9pA:7.2 | 4obwA-5u9pA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ug4 | SPERMIDINEN(1)-ACETYLTRANSFERASE (Vibrio cholerae) |
PF13302(Acetyltransf_3) | 5 | ALA A 90ILE A 88GLY A 69ASN A 20PHE A 17 | None | 1.08A | 4obwA-5ug4A:3.9 | 4obwA-5ug4A:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uyt | ICE-BINDING PROTEIN (Flavobacteriaceaebacterium3519-10) |
no annotation | 5 | ALA A 77GLY A 76GLY A 55ASN A 32PHE A 33 | None | 1.17A | 4obwA-5uytA:undetectable | 4obwA-5uytA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5voh | NADH OXIDASE (Lactobacillusbrevis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | TYR A 318ALA A 277GLY A 304ASN A 299GLY A 112 | NoneNoneNoneNoneFAD A 501 (-2.6A) | 1.25A | 4obwA-5vohA:undetectable | 4obwA-5vohA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xmb | PANTOTHENATE KINASE (Mycobacteriumtuberculosis) |
no annotation | 5 | ALA A 96GLY A 97SER A 98ASN A 204GLY A 94 | None | 1.12A | 4obwA-5xmbA:undetectable | 4obwA-5xmbA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zi9 | CYTOKININ RIBOSIDE5'-MONOPHOSPHATEPHOSPHORIBOHYDROLASE (Streptomycescoelicolor) |
no annotation | 5 | ASN A 144SER A 130GLY A 64ASN A 152PHE A 153 | None | 1.20A | 4obwA-5zi9A:undetectable | 4obwA-5zi9A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b4o | GLUTATHIONEREDUCTASE (Enterococcusfaecalis) |
no annotation | 5 | ASN A 99GLY A 12ILE A 314GLY A 317ASN A 20 | NoneFAD A 501 (-3.3A)NoneNone CL A 504 (-4.2A) | 1.25A | 4obwA-6b4oA:2.1 | 4obwA-6b4oA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bj9 | ACETYL-COAACETYLTRANSFERASE A (Ascaris suum) |
no annotation | 5 | ALA A 355GLY A 94SER A 93ASN A 316GLY A 359 | None | 1.16A | 4obwA-6bj9A:undetectable | 4obwA-6bj9A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bj9 | ACETYL-COAACETYLTRANSFERASE A (Ascaris suum) |
no annotation | 5 | ALA A 355GLY A 94SER A 93ILE A 357GLY A 359 | None | 1.12A | 4obwA-6bj9A:undetectable | 4obwA-6bj9A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gct | NEUTRAL AMINO ACIDTRANSPORTER B(0) (Homo sapiens) |
no annotation | 5 | TYR A 325ALA A 479GLY A 478ASN A 484ASN A 368 | None | 1.01A | 4obwA-6gctA:undetectable | 4obwA-6gctA:undetectable |