SIMILAR PATTERNS OF AMINO ACIDS FOR 4OBW_A_SAMA602_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE


(Pyrococcus
furiosus)
PF01314
(AFOR_C)
PF02730
(AFOR_N)
5 ALA A 174
GLY A 188
SER A  83
ILE A 163
GLY A 341
None
1.24A 4obwA-1aorA:
undetectable
4obwA-1aorA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Thermoanaerobacter
brockii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 242
GLY A 174
ILE A 240
GLY A 155
ASN A 264
None
1.15A 4obwA-1bxzA:
7.8
4obwA-1bxzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzv NITRITE REDUCTASE

(Pseudomonas
aeruginosa)
PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3)
5 ALA A 200
GLY A 221
ILE A 202
MET A 124
GLY A 197
None
1.24A 4obwA-1hzvA:
undetectable
4obwA-1hzvA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig0 THIAMIN
PYROPHOSPHOKINASE


(Saccharomyces
cerevisiae)
PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding)
5 TYR A 109
ALA A  71
GLY A  70
ILE A  48
GLY A 190
None
1.02A 4obwA-1ig0A:
2.3
4obwA-1ig0A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE


(Comamonas
testosteroni)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3)
5 ASN A 427
ALA A 184
GLY A 183
SER A 163
GLY A 262
None
PQQ  A1800 (-3.2A)
PQQ  A1800 (-3.7A)
None
None
1.22A 4obwA-1kb0A:
undetectable
4obwA-1kb0A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa)
PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s)
5 ALA A 186
GLY A 189
SER A 195
ILE A 184
ASN A 182
None
1.25A 4obwA-1lnlA:
undetectable
4obwA-1lnlA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg5 ALCOHOL
DEHYDROGENASE


(Drosophila
melanogaster)
PF00106
(adh_short)
5 ALA A  13
GLY A  14
SER A  23
GLY A  94
ASN A  91
NAI  A 850 (-3.2A)
None
None
NAI  A 850 (-3.5A)
None
1.04A 4obwA-1mg5A:
6.2
4obwA-1mg5A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nff PUTATIVE
OXIDOREDUCTASE
RV2002


(Mycobacterium
tuberculosis)
PF13561
(adh_short_C2)
5 ALA A 168
GLY A 229
SER A 180
ILE A 176
GLY A 172
None
1.23A 4obwA-1nffA:
7.2
4obwA-1nffA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE


(Escherichia
coli)
PF01156
(IU_nuc_hydro)
5 ALA A 153
GLY A 188
ILE A 167
ASN A 166
MET A 150
None
None
None
GOL  A3001 (-3.3A)
GOL  A3001 (-3.4A)
1.22A 4obwA-1q8fA:
3.4
4obwA-1q8fA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE


(Enterovirus C)
PF00680
(RdRP_1)
5 ASN A  18
ALA A 209
SER A 294
GLY A 203
PHE A 217
None
1.08A 4obwA-1rdrA:
undetectable
4obwA-1rdrA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE


(Cavia porcellus)
PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2)
5 TYR A 214
ALA A 172
GLY A 171
ASN A 217
GLY A 174
None
None
None
NAP  A1350 (-3.9A)
NAP  A1350 (-3.2A)
0.89A 4obwA-1v3tA:
7.2
4obwA-1v3tA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226


(Pyrococcus
horikoshii)
PF13649
(Methyltransf_25)
5 TYR A   7
ALA A  46
ILE A  68
MET A  72
PHE A 116
SAM  A 302 (-4.6A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-4.4A)
1.16A 4obwA-1ve3A:
7.6
4obwA-1ve3A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
5 TYR A 363
ALA A 304
SER A 367
MET A 344
GLY A 264
None
None
None
None
IOD  A9050 ( 3.8A)
1.23A 4obwA-1xc6A:
undetectable
4obwA-1xc6A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium)
PF00840
(Glyco_hydro_7)
5 TYR A  51
ASN A  49
ASN A  37
GLY A 102
ASN A 195
None
1.21A 4obwA-1z3vA:
undetectable
4obwA-1z3vA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9n SUPEROXIDE DISMUTASE
[CU-ZN]


([Haemophilus]
ducreyi)
PF00080
(Sod_Cu)
5 GLY A 174
SER A 147
MET A 149
GLY A  42
ASN A  38
None
1.13A 4obwA-1z9nA:
undetectable
4obwA-1z9nA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9p SUPEROXIDE DISMUTASE
[CU-ZN]


([Haemophilus]
ducreyi)
PF00080
(Sod_Cu)
5 GLY A 174
SER A 147
MET A 149
GLY A  42
ASN A  38
None
1.18A 4obwA-1z9pA:
undetectable
4obwA-1z9pA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqt SUPEROXIDE DISMUTASE
[CU-ZN]


(Neisseria
meningitidis)
no annotation 5 GLY C 183
SER C 156
MET C 158
GLY C  51
ASN C  47
None
1.19A 4obwA-2aqtC:
undetectable
4obwA-2aqtC:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE


(Candida
tropicalis)
PF00106
(adh_short)
5 ALA A 472
GLY A 457
SER A 456
ILE A 474
GLY A 476
None
1.09A 4obwA-2et6A:
5.4
4obwA-2et6A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE


(Shewanella
oneidensis)
PF00920
(ILVD_EDD)
5 ALA A 314
GLY A 315
SER A  16
ASN A 283
GLY A 169
None
1.05A 4obwA-2gp4A:
undetectable
4obwA-2gp4A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE


(Homo sapiens)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ALA A 392
GLY A 129
SER A 128
ASN A 353
GLY A 396
None
None
CSO  A 126 ( 4.8A)
None
None
1.13A 4obwA-2ibuA:
undetectable
4obwA-2ibuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE


(Homo sapiens)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ALA A 392
GLY A 129
SER A 128
ILE A 394
GLY A 396
None
None
CSO  A 126 ( 4.8A)
None
None
1.13A 4obwA-2ibuA:
undetectable
4obwA-2ibuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jks BRADYZOITE SURFACE
ANTIGEN BSR4


(Toxoplasma
gondii)
PF04092
(SAG)
5 GLY A 206
SER A 204
ILE A 200
ASN A 201
GLY A 274
None
ZN  A1320 ( 4.9A)
None
None
None
1.18A 4obwA-2jksA:
undetectable
4obwA-2jksA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m4l PROTEIN BT_0846

(Bacteroides
thetaiotaomicron)
no annotation 5 GLY A  14
SER A  28
ILE A  79
GLY A  81
ASN A  10
None
1.05A 4obwA-2m4lA:
undetectable
4obwA-2m4lA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mvb UNCHARACTERIZED
PROTEIN


(Streptococcus
pneumoniae)
no annotation 5 TYR A 153
ASN A 148
GLY A 141
ILE A  58
PHE A 121
None
1.17A 4obwA-2mvbA:
undetectable
4obwA-2mvbA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E)
PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C)
5 ASN A 306
GLY A 309
ILE A 572
GLY A 316
ASN A 570
None
1.20A 4obwA-2obeA:
undetectable
4obwA-2obeA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE


(unidentified)
PF01979
(Amidohydro_1)
5 ALA A 392
GLY A 393
SER A 332
ILE A 387
GLY A  24
None
1.21A 4obwA-2pajA:
3.2
4obwA-2pajA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtc CEL61B

(Trichoderma
reesei)
PF03443
(Glyco_hydro_61)
5 ALA A 167
GLY A 172
GLY A 208
ASN A 212
PHE A 211
None
1.20A 4obwA-2vtcA:
undetectable
4obwA-2vtcA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2)
5 TYR A 214
ALA A 172
GLY A 171
ASN A 217
GLY A 174
None
None
None
NAP  A 701 (-3.8A)
NAP  A 701 (-3.3A)
0.99A 4obwA-2y05A:
7.9
4obwA-2y05A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylz PHENYLACETONE
MONOOXYGENASE


(Thermobifida
fusca)
PF13738
(Pyr_redox_3)
5 ASN A  58
GLY A 198
SER A 196
ILE A 192
GLY A 190
FAD  A 700 (-4.2A)
None
SO4  A1543 (-4.6A)
None
None
1.06A 4obwA-2ylzA:
undetectable
4obwA-2ylzA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2


(Rattus
norvegicus)
PF01150
(GDA1_CD39)
5 ALA A 123
GLY A 124
SER A  83
ASN A 129
GLY A 162
None
0.96A 4obwA-3cj1A:
undetectable
4obwA-3cj1A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clk TRANSCRIPTION
REGULATOR


(Lactobacillus
plantarum)
PF13377
(Peripla_BP_3)
5 ALA A 184
GLY A 185
ILE A 216
GLY A 182
PHE A 233
None
1.04A 4obwA-3clkA:
2.9
4obwA-3clkA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3a BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron)
PF01301
(Glyco_hydro_35)
5 ASN A 216
ALA A 185
GLY A 184
GLY A 474
PHE A 473
None
1.18A 4obwA-3d3aA:
undetectable
4obwA-3d3aA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE


(Homo sapiens)
PF00480
(ROK)
5 ASN A 516
ALA A 524
GLY A 708
MET A 712
GLY A 529
None
1.22A 4obwA-3eo3A:
undetectable
4obwA-3eo3A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Clostridium
beijerinckii;
Thermoanaerobacter
brockii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 242
GLY A 174
ILE A 240
GLY A 155
ASN A 264
None
1.24A 4obwA-3fplA:
7.7
4obwA-3fplA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7s LONG-CHAIN-FATTY-ACI
D--COA LIGASE
(FADD-1)


(Archaeoglobus
fulgidus)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 ASN A  84
ALA A 232
GLY A 235
ILE A 332
GLY A 334
None
1.26A 4obwA-3g7sA:
undetectable
4obwA-3g7sA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE


(Yersinia pestis)
PF00709
(Adenylsucc_synt)
5 ASN A  39
ALA A 137
GLY A 135
SER A 241
GLY A 146
None
1.15A 4obwA-3hidA:
2.2
4obwA-3hidA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE


(Aeromonas
sobria)
PF00082
(Peptidase_S8)
PF01483
(P_proprotein)
5 ALA A 453
GLY A 456
SER A 385
ASN A 556
GLY A 583
None
1.18A 4obwA-3hjrA:
undetectable
4obwA-3hjrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT


(Eubacterium
barkeri)
PF02738
(Ald_Xan_dh_C2)
5 ALA B  25
GLY B 160
ILE B  92
ASN B  95
GLY B  81
None
1.22A 4obwA-3hrdB:
undetectable
4obwA-3hrdB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1


(Thermus
thermophilus)
PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S)
5 ASN 1 343
GLY 1  99
SER 1 295
ILE 1 254
GLY 1 262
None
FES  2 182 ( 4.8A)
None
None
None
0.99A 4obwA-3i9v1:
2.6
4obwA-3i9v1:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF17


(Schizosaccharomyces
pombe)
PF00400
(WD40)
5 ASN L  85
GLY L  68
SER L  67
GLY L  94
ASN L  90
None
1.25A 4obwA-3jb9L:
undetectable
4obwA-3jb9L:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT


(Methanosarcina
mazei)
PF02384
(N6_Mtase)
PF12161
(HsdM_N)
5 TYR A 226
ASN A 432
GLY A 253
SER A 254
ASN A 291
None
1.23A 4obwA-3khkA:
11.8
4obwA-3khkA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khp MAOC FAMILY PROTEIN

(Mycobacterium
tuberculosis)
PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N)
5 ALA A  67
GLY A  65
GLY A  71
ASN A  74
PHE A  73
None
0.99A 4obwA-3khpA:
undetectable
4obwA-3khpA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE


(Sulfolobus
solfataricus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A  13
GLY A 305
ILE A 135
MET A 294
GLY A   9
ADP  A 465 (-3.2A)
ADP  A 465 (-3.3A)
None
None
ADP  A 465 (-3.4A)
1.26A 4obwA-3l8kA:
2.6
4obwA-3l8kA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2


(Dichelobacter
nodosus)
PF00082
(Peptidase_S8)
5 ALA A 124
GLY A 125
ASN A  53
GLY A 122
ASN A 118
None
None
None
CA  A   1 ( 4.3A)
None
1.14A 4obwA-3lpdA:
2.5
4obwA-3lpdA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6i L-ARABINITOL
4-DEHYDROGENASE


(Neurospora
crassa)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 TYR A 309
ASN A 120
GLY A 171
ILE A 194
GLY A 192
None
1.22A 4obwA-3m6iA:
8.3
4obwA-3m6iA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpp BOTULINUM NEUROTOXIN
TYPE G


(Clostridium
botulinum)
PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N)
5 ALA G 869
SER G 883
ILE G1069
GLY G1071
ASN G 936
None
1.09A 4obwA-3mppG:
undetectable
4obwA-3mppG:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8q SHIKIMATE
5-DEHYDROGENASE I
ALPHA


(Vibrio cholerae)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
5 ASN B  90
ALA B 250
GLY B 247
ILE B 266
GLY B 262
None
1.22A 4obwA-3o8qB:
2.2
4obwA-3o8qB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovg AMIDOHYDROLASE

(Mycoplasma
synoviae)
PF02126
(PTE)
5 GLY A  11
ILE A  94
ASN A  92
GLY A 150
PHE A 328
None
1.14A 4obwA-3ovgA:
undetectable
4obwA-3ovgA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxn KINESIN-LIKE PROTEIN
NOD


(Drosophila
melanogaster)
PF00225
(Kinesin)
5 GLY A 252
SER A 255
ILE A 249
ASN A 248
GLY A 229
None
0.99A 4obwA-3pxnA:
undetectable
4obwA-3pxnA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvm OLEI00960

(Oleispira
antarctica)
PF00561
(Abhydrolase_1)
5 TYR A  61
ASN A  18
ALA A  84
GLY A  82
ILE A 109
None
1.25A 4obwA-3qvmA:
3.2
4obwA-3qvmA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI


(Bacillus
pumilus)
PF02384
(N6_Mtase)
PF15516
(BpuSI_N)
5 ALA A 329
GLY A 331
SER A 332
ILE A 356
PHE A 447
SAH  A 900 (-3.2A)
SAH  A 900 (-3.2A)
SAH  A 900 (-2.6A)
SAH  A 900 (-3.8A)
None
1.20A 4obwA-3s1sA:
11.5
4obwA-3s1sA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II


(Ascaris suum)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
5 ASN A 252
ALA A  52
GLY A  50
ILE A 233
GLY A 445
FAD  A 702 ( 3.7A)
FAD  A 702 (-4.0A)
FAD  A 702 (-3.0A)
None
None
0.98A 4obwA-3vrbA:
undetectable
4obwA-3vrbA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum)
PF13229
(Beta_helix)
5 TYR A 494
ASN A 495
ILE A 424
ASN A 426
GLY A 440
None
1.06A 4obwA-3vsvA:
undetectable
4obwA-3vsvA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE


(Bifidobacterium
longum)
PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C)
5 ASN A 720
GLY A 340
SER A 478
ILE A 394
GLY A 357
None
1.22A 4obwA-3wfzA:
undetectable
4obwA-3wfzA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtb PUTATIVE
OXIDOREDUCTASE


(Gluconobacter
oxydans)
PF13561
(adh_short_C2)
5 TYR A 135
ALA A 167
GLY A 232
ILE A 175
GLY A 171
None
1.11A 4obwA-3wtbA:
6.7
4obwA-3wtbA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6u OMEGA TRANSAMINASE

(Chromobacterium
violaceum)
PF00202
(Aminotran_3)
5 ALA A 287
GLY A 120
SER A 121
ILE A 262
GLY A 264
None
1.23A 4obwA-4a6uA:
undetectable
4obwA-4a6uA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap3 STEROID
MONOOXYGENASE


(Rhodococcus
rhodochrous)
PF00743
(FMO-like)
5 ASN A  63
GLY A 203
SER A 201
ILE A 197
GLY A 195
FAD  A1552 (-4.4A)
None
NAP  A1553 (-2.9A)
None
None
1.01A 4obwA-4ap3A:
2.1
4obwA-4ap3A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA


(Mycobacterium
tuberculosis)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ALA C 366
GLY C  95
SER C  94
ASN C 327
GLY C 370
None
1.13A 4obwA-4b3iC:
undetectable
4obwA-4b3iC:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA


(Mycobacterium
tuberculosis)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ALA C 366
GLY C  95
SER C  94
ILE C 368
GLY C 370
None
1.14A 4obwA-4b3iC:
undetectable
4obwA-4b3iC:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cql ESTRADIOL
17-BETA-DEHYDROGENAS
E 8


(Homo sapiens)
PF13561
(adh_short_C2)
5 ALA A 184
GLY A 250
SER A 196
ILE A 192
GLY A 188
None
1.26A 4obwA-4cqlA:
7.3
4obwA-4cqlA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5r A49

(Vaccinia virus)
PF06489
(Orthopox_A49R)
5 GLY A 134
SER A 135
ILE A  47
ASN A  44
ASN A  49
None
1.22A 4obwA-4d5rA:
undetectable
4obwA-4d5rA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata)
PF00840
(Glyco_hydro_7)
5 TYR A  68
ASN A  66
ASN A  54
GLY A 126
ASN A 221
None
1.25A 4obwA-4haqA:
undetectable
4obwA-4haqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Vibrio cholerae)
no annotation 5 ASN D 170
ILE D 149
ASN D 146
GLY D 152
ASN D 157
None
1.23A 4obwA-4jrmD:
undetectable
4obwA-4jrmD:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4y TRANSCRIPTIONAL
REGULATOR LSRR


(Escherichia
coli)
PF04198
(Sugar-bind)
5 TYR A 156
GLY A 125
ILE A 207
MET A 129
GLY A 281
None
1.25A 4obwA-4l4yA:
5.6
4obwA-4l4yA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE


(Vibrio cholerae)
PF13302
(Acetyltransf_3)
5 ALA A  90
ILE A  88
GLY A  69
ASN A  20
PHE A  17
None
0.96A 4obwA-4mi4A:
2.8
4obwA-4mi4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY


(Brucella suis)
PF13561
(adh_short_C2)
5 ALA A  11
SER A  55
ILE A   9
GLY A  17
ASN A  81
None
1.26A 4obwA-4o6vA:
6.5
4obwA-4o6vA:
25.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF01209
(Ubie_methyltran)
12 TYR A  78
ASN A  82
LYS A  94
ALA A 119
GLY A 120
SER A 122
ILE A 149
ASN A 150
MET A 153
GLY A 180
ASN A 202
PHE A 203
SAM  A 602 (-3.9A)
SAM  A 602 ( 4.2A)
SAM  A 602 (-3.3A)
SAM  A 602 (-3.2A)
SAM  A 602 (-3.4A)
SAM  A 602 (-3.1A)
SAM  A 602 (-3.8A)
SAM  A 602 (-4.9A)
SAM  A 602 (-3.7A)
SAM  A 602 (-3.5A)
SAM  A 602 ( 4.9A)
SAM  A 602 (-3.9A)
0.04A 4obwA-4obwA:
43.8
4obwA-4obwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF01209
(Ubie_methyltran)
7 TYR A  78
GLY A 121
SER A 122
ILE A 149
ASN A 150
GLY A 180
ASN A 202
SAM  A 602 (-3.9A)
None
SAM  A 602 (-3.1A)
SAM  A 602 (-3.8A)
SAM  A 602 (-4.9A)
SAM  A 602 (-3.5A)
SAM  A 602 ( 4.9A)
1.10A 4obwA-4obwA:
43.8
4obwA-4obwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc9 PUTATIVE
O-ACETYLHOMOSERINE
(THIOL)-LYASE


(Campylobacter
jejuni)
PF01053
(Cys_Met_Meta_PP)
5 ALA A 217
GLY A 216
SER A  82
ILE A  78
GLY A  65
None
None
LLP  A 205 ( 3.7A)
None
None
1.18A 4obwA-4oc9A:
3.0
4obwA-4oc9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wem ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION


(Lama glama)
PF07686
(V-set)
5 GLY B 901
SER B 898
ILE B 851
GLY B 855
ASN B 858
None
1.22A 4obwA-4wemB:
undetectable
4obwA-4wemB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA


(Shewanella
loihica)
PF01156
(IU_nuc_hydro)
5 ALA A 199
GLY A 234
ILE A 213
ASN A 212
MET A 196
1PE  A 402 ( 4.4A)
None
None
CA  A 401 ( 4.4A)
None
1.24A 4obwA-4wr2A:
undetectable
4obwA-4wr2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2


(Vibrio cholerae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 ASN A 110
GLY A 312
ILE A 190
GLY A 216
PHE A 214
None
SCY  A 113 ( 3.1A)
None
None
None
1.20A 4obwA-4x0oA:
undetectable
4obwA-4x0oA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x68 BETA-LACTAMASE

(Pseudomonas
aeruginosa)
PF00144
(Beta-lactamase)
5 ALA A 367
GLY A 350
SER A 345
GLY A  53
ASN A  49
None
None
OP0  A 401 (-4.6A)
None
None
1.10A 4obwA-4x68A:
undetectable
4obwA-4x68A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620)
no annotation 5 ASN A 315
ALA A 287
GLY A 289
ILE A 310
GLY A 285
NAG  A1004 (-3.1A)
None
None
None
None
1.25A 4obwA-4xn3A:
undetectable
4obwA-4xn3A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9r OMEGA-3
POLYUNSATURATED
FATTY ACID SYNTHASE
SUBUNIT PFAD


(Shewanella
oneidensis)
PF03060
(NMO)
5 LYS A 294
ALA A 311
GLY A 310
ILE A 315
GLY A 313
None
None
None
None
FMN  A 602 (-3.4A)
0.98A 4obwA-4z9rA:
undetectable
4obwA-4z9rA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA


(Schizosaccharomyces
pombe)
PF01008
(IF-2B)
5 ALA A  81
GLY A  82
ILE A  77
ASN A  76
GLY A 213
None
1.09A 4obwA-5b04A:
2.6
4obwA-5b04A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN


(Homo sapiens)
PF00012
(HSP70)
5 GLY A 216
ILE A 220
ASN A 219
GLY A 210
PHE A 242
None
1.24A 4obwA-5e84A:
undetectable
4obwA-5e84A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE


(Pseudomonas
syringae group
genomosp. 3)
PF00144
(Beta-lactamase)
5 ALA B 338
GLY B 321
SER B 316
GLY B  26
ASN B  22
MLY  B 340 ( 4.0A)
MLY  B 340 ( 3.1A)
None
None
None
1.08A 4obwA-5eviB:
undetectable
4obwA-5eviB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewx ENDOLYSIN,IMMUNOGLOB
ULIN G-BINDING
PROTEIN A,ENDOLYSIN


(Staphylococcus
aureus;
Escherichia
virus T4)
PF00959
(Phage_lysozyme)
PF02216
(B)
5 TYR A 161
ILE A   3
MET A   1
ASN A 101
PHE A 104
None
1.20A 4obwA-5ewxA:
undetectable
4obwA-5ewxA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA


(Moorella
thermoacetica)
PF02775
(TPP_enzyme_C)
5 ALA C 113
GLY C 111
SER C 149
GLY C  77
PHE C 133
None
5SR  C 402 (-3.4A)
None
None
None
1.26A 4obwA-5exeC:
2.9
4obwA-5exeC:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE


(Desulfovibrio
alaskensis)
PF01228
(Gly_radical)
PF02901
(PFL-like)
5 GLY A 726
SER A 724
ILE A 700
ASN A 702
GLY A 821
None
1.25A 4obwA-5favA:
undetectable
4obwA-5favA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA, PUTATIVE


(Plasmodium
falciparum)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
5 GLY A 144
SER A 143
ILE A  75
ASN A  74
GLY A  83
None
1.11A 4obwA-5fmgA:
undetectable
4obwA-5fmgA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD


(Pseudomonas
aeruginosa)
PF01734
(Patatin)
5 ASN A 234
GLY A 208
SER A  60
ILE A 168
GLY A 171
None
1.07A 4obwA-5fyaA:
2.4
4obwA-5fyaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs7 CHOLOYLGLYCINE
HYDROLASE


(Enterococcus
faecalis)
PF02275
(CBAH)
5 ASN A 170
ALA A  76
GLY A  77
GLY A  74
PHE A  14
None
1.25A 4obwA-5gs7A:
undetectable
4obwA-5gs7A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzl LMO2445 PROTEIN

(Listeria
monocytogenes)
no annotation 5 ALA B 155
GLY B 156
SER B 158
ILE B 113
GLY B 110
None
None
PG5  B 408 ( 4.2A)
None
None
1.26A 4obwA-5hzlB:
undetectable
4obwA-5hzlB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN


(Bacteroides
cellulosilyticus)
no annotation 5 TYR A 311
ALA A 294
GLY A 286
SER A 285
GLY A 330
None
None
None
None
SO4  A 651 (-3.3A)
1.20A 4obwA-5jvkA:
undetectable
4obwA-5jvkA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE


(Streptomyces
violaceusniger)
PF04820
(Trp_halogenase)
5 ALA A  13
GLY A 349
SER A 352
ILE A   7
GLY A  10
None
1.20A 4obwA-5lv9A:
4.1
4obwA-5lv9A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mln ALCOHOL
DEHYDROGENASE 3


([Candida]
magnoliae)
no annotation 5 TYR A 141
ALA A 172
GLY A 230
ILE A 180
GLY A 176
None
1.25A 4obwA-5mlnA:
6.4
4obwA-5mlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sz8 HEMOLYSIN

(Proteus
mirabilis)
PF05860
(Haemagg_act)
5 ASN A  96
ALA A  92
GLY A  93
ASN A  47
GLY A  77
None
1.23A 4obwA-5sz8A:
undetectable
4obwA-5sz8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti8 AMINOTRANSFERASE

(Pseudomonas sp.
M1)
PF00202
(Aminotran_3)
5 ALA A 289
GLY A 122
SER A 123
ILE A 264
GLY A 266
None
1.19A 4obwA-5ti8A:
undetectable
4obwA-5ti8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9p GLUCONATE
5-DEHYDROGENASE


(Burkholderia
cenocepacia)
PF13561
(adh_short_C2)
5 TYR A 161
GLY A  98
ILE A  24
GLY A  23
ASN A 199
TLA  A 302 ( 4.0A)
NAP  A 301 (-3.8A)
NAP  A 301 (-3.9A)
NAP  A 301 (-3.5A)
TLA  A 302 ( 3.0A)
1.17A 4obwA-5u9pA:
7.2
4obwA-5u9pA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ug4 SPERMIDINE
N(1)-ACETYLTRANSFERA
SE


(Vibrio cholerae)
PF13302
(Acetyltransf_3)
5 ALA A  90
ILE A  88
GLY A  69
ASN A  20
PHE A  17
None
1.08A 4obwA-5ug4A:
3.9
4obwA-5ug4A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyt ICE-BINDING PROTEIN

(Flavobacteriaceae
bacterium
3519-10)
no annotation 5 ALA A  77
GLY A  76
GLY A  55
ASN A  32
PHE A  33
None
1.17A 4obwA-5uytA:
undetectable
4obwA-5uytA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voh NADH OXIDASE

(Lactobacillus
brevis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 TYR A 318
ALA A 277
GLY A 304
ASN A 299
GLY A 112
None
None
None
None
FAD  A 501 (-2.6A)
1.25A 4obwA-5vohA:
undetectable
4obwA-5vohA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmb PANTOTHENATE KINASE

(Mycobacterium
tuberculosis)
no annotation 5 ALA A  96
GLY A  97
SER A  98
ASN A 204
GLY A  94
None
1.12A 4obwA-5xmbA:
undetectable
4obwA-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zi9 CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE


(Streptomyces
coelicolor)
no annotation 5 ASN A 144
SER A 130
GLY A  64
ASN A 152
PHE A 153
None
1.20A 4obwA-5zi9A:
undetectable
4obwA-5zi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4o GLUTATHIONE
REDUCTASE


(Enterococcus
faecalis)
no annotation 5 ASN A  99
GLY A  12
ILE A 314
GLY A 317
ASN A  20
None
FAD  A 501 (-3.3A)
None
None
CL  A 504 (-4.2A)
1.25A 4obwA-6b4oA:
2.1
4obwA-6b4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bj9 ACETYL-COA
ACETYLTRANSFERASE A


(Ascaris suum)
no annotation 5 ALA A 355
GLY A  94
SER A  93
ASN A 316
GLY A 359
None
1.16A 4obwA-6bj9A:
undetectable
4obwA-6bj9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bj9 ACETYL-COA
ACETYLTRANSFERASE A


(Ascaris suum)
no annotation 5 ALA A 355
GLY A  94
SER A  93
ILE A 357
GLY A 359
None
1.12A 4obwA-6bj9A:
undetectable
4obwA-6bj9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)


(Homo sapiens)
no annotation 5 TYR A 325
ALA A 479
GLY A 478
ASN A 484
ASN A 368
None
1.01A 4obwA-6gctA:
undetectable
4obwA-6gctA:
undetectable