SIMILAR PATTERNS OF AMINO ACIDS FOR 4OBW_A_SAMA602
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aor | ALDEHYDE FERREDOXINOXIDOREDUCTASE (Pyrococcusfuriosus) |
PF01314(AFOR_C)PF02730(AFOR_N) | 5 | ALA A 174GLY A 188SER A 83ILE A 163GLY A 341 | None | 1.24A | 4obwA-1aorA:undetectable | 4obwA-1aorA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bxz | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 242GLY A 174ILE A 240GLY A 155ASN A 264 | None | 1.15A | 4obwA-1bxzA:7.8 | 4obwA-1bxzA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hzv | NITRITE REDUCTASE (Pseudomonasaeruginosa) |
PF02239(Cytochrom_D1)PF13442(Cytochrome_CBB3) | 5 | ALA A 200GLY A 221ILE A 202MET A 124GLY A 197 | None | 1.24A | 4obwA-1hzvA:undetectable | 4obwA-1hzvA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ig0 | THIAMINPYROPHOSPHOKINASE (Saccharomycescerevisiae) |
PF04263(TPK_catalytic)PF04265(TPK_B1_binding) | 5 | TYR A 109ALA A 71GLY A 70ILE A 48GLY A 190 | None | 1.02A | 4obwA-1ig0A:2.3 | 4obwA-1ig0A:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kb0 | QUINOHEMOPROTEINALCOHOLDEHYDROGENASE (Comamonastestosteroni) |
PF13360(PQQ_2)PF13442(Cytochrome_CBB3) | 5 | ASN A 427ALA A 184GLY A 183SER A 163GLY A 262 | NonePQQ A1800 (-3.2A)PQQ A1800 (-3.7A)NoneNone | 1.22A | 4obwA-1kb0A:undetectable | 4obwA-1kb0A:16.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lnl | HEMOCYANIN (Rapana venosa) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | ALA A 186GLY A 189SER A 195ILE A 184ASN A 182 | None | 1.25A | 4obwA-1lnlA:undetectable | 4obwA-1lnlA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mg5 | ALCOHOLDEHYDROGENASE (Drosophilamelanogaster) |
PF00106(adh_short) | 5 | ALA A 13GLY A 14SER A 23GLY A 94ASN A 91 | NAI A 850 (-3.2A)NoneNoneNAI A 850 (-3.5A)None | 1.04A | 4obwA-1mg5A:6.2 | 4obwA-1mg5A:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nff | PUTATIVEOXIDOREDUCTASERV2002 (Mycobacteriumtuberculosis) |
PF13561(adh_short_C2) | 5 | ALA A 168GLY A 229SER A 180ILE A 176GLY A 172 | None | 1.23A | 4obwA-1nffA:7.2 | 4obwA-1nffA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8f | PYRIMIDINENUCLEOSIDE HYDROLASE (Escherichiacoli) |
PF01156(IU_nuc_hydro) | 5 | ALA A 153GLY A 188ILE A 167ASN A 166MET A 150 | NoneNoneNoneGOL A3001 (-3.3A)GOL A3001 (-3.4A) | 1.22A | 4obwA-1q8fA:3.4 | 4obwA-1q8fA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rdr | POLIOVIRUS 3DPOLYMERASE (Enterovirus C) |
PF00680(RdRP_1) | 5 | ASN A 18ALA A 209SER A 294GLY A 203PHE A 217 | None | 1.08A | 4obwA-1rdrA:undetectable | 4obwA-1rdrA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v3t | LEUKOTRIENE B412-HYDROXYDEHYDROGENASE/PROSTAGLANDIN15-KETO REDUCTASE (Cavia porcellus) |
PF00107(ADH_zinc_N)PF16884(ADH_N_2) | 5 | TYR A 214ALA A 172GLY A 171ASN A 217GLY A 174 | NoneNoneNoneNAP A1350 (-3.9A)NAP A1350 (-3.2A) | 0.89A | 4obwA-1v3tA:7.2 | 4obwA-1v3tA:24.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ve3 | HYPOTHETICAL PROTEINPH0226 (Pyrococcushorikoshii) |
PF13649(Methyltransf_25) | 5 | TYR A 7ALA A 46ILE A 68MET A 72PHE A 116 | SAM A 302 (-4.6A)SAM A 302 (-3.4A)SAM A 302 (-3.7A)SAM A 302 (-3.9A)SAM A 302 (-4.4A) | 1.16A | 4obwA-1ve3A:7.6 | 4obwA-1ve3A:24.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xc6 | BETA-GALACTOSIDASE (Penicillium sp.) |
PF01301(Glyco_hydro_35)PF10435(BetaGal_dom2)PF13363(BetaGal_dom3)PF13364(BetaGal_dom4_5) | 5 | TYR A 363ALA A 304SER A 367MET A 344GLY A 264 | NoneNoneNoneNoneIOD A9050 ( 3.8A) | 1.23A | 4obwA-1xc6A:undetectable | 4obwA-1xc6A:13.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3v | CELLULASE (Phanerochaetechrysosporium) |
PF00840(Glyco_hydro_7) | 5 | TYR A 51ASN A 49ASN A 37GLY A 102ASN A 195 | None | 1.21A | 4obwA-1z3vA:undetectable | 4obwA-1z3vA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z9n | SUPEROXIDE DISMUTASE[CU-ZN] ([Haemophilus]ducreyi) |
PF00080(Sod_Cu) | 5 | GLY A 174SER A 147MET A 149GLY A 42ASN A 38 | None | 1.13A | 4obwA-1z9nA:undetectable | 4obwA-1z9nA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z9p | SUPEROXIDE DISMUTASE[CU-ZN] ([Haemophilus]ducreyi) |
PF00080(Sod_Cu) | 5 | GLY A 174SER A 147MET A 149GLY A 42ASN A 38 | None | 1.18A | 4obwA-1z9pA:undetectable | 4obwA-1z9pA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aqt | SUPEROXIDE DISMUTASE[CU-ZN] (Neisseriameningitidis) |
no annotation | 5 | GLY C 183SER C 156MET C 158GLY C 51ASN C 47 | None | 1.19A | 4obwA-2aqtC:undetectable | 4obwA-2aqtC:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2et6 | (3R)-HYDROXYACYL-COADEHYDROGENASE (Candidatropicalis) |
PF00106(adh_short) | 5 | ALA A 472GLY A 457SER A 456ILE A 474GLY A 476 | None | 1.09A | 4obwA-2et6A:5.4 | 4obwA-2et6A:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gp4 | 6-PHOSPHOGLUCONATEDEHYDRATASE (Shewanellaoneidensis) |
PF00920(ILVD_EDD) | 5 | ALA A 314GLY A 315SER A 16ASN A 283GLY A 169 | None | 1.05A | 4obwA-2gp4A:undetectable | 4obwA-2gp4A:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ibu | ACETYL-COAACETYLTRANSFERASE (Homo sapiens) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA A 392GLY A 129SER A 128ASN A 353GLY A 396 | NoneNoneCSO A 126 ( 4.8A)NoneNone | 1.13A | 4obwA-2ibuA:undetectable | 4obwA-2ibuA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ibu | ACETYL-COAACETYLTRANSFERASE (Homo sapiens) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA A 392GLY A 129SER A 128ILE A 394GLY A 396 | NoneNoneCSO A 126 ( 4.8A)NoneNone | 1.13A | 4obwA-2ibuA:undetectable | 4obwA-2ibuA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jks | BRADYZOITE SURFACEANTIGEN BSR4 (Toxoplasmagondii) |
PF04092(SAG) | 5 | GLY A 206SER A 204ILE A 200ASN A 201GLY A 274 | None ZN A1320 ( 4.9A)NoneNoneNone | 1.18A | 4obwA-2jksA:undetectable | 4obwA-2jksA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m4l | PROTEIN BT_0846 (Bacteroidesthetaiotaomicron) |
no annotation | 5 | GLY A 14SER A 28ILE A 79GLY A 81ASN A 10 | None | 1.05A | 4obwA-2m4lA:undetectable | 4obwA-2m4lA:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mvb | UNCHARACTERIZEDPROTEIN (Streptococcuspneumoniae) |
no annotation | 5 | TYR A 153ASN A 148GLY A 141ILE A 58PHE A 121 | None | 1.17A | 4obwA-2mvbA:undetectable | 4obwA-2mvbA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2obe | HEXON (HumanmastadenovirusE) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 5 | ASN A 306GLY A 309ILE A 572GLY A 316ASN A 570 | None | 1.20A | 4obwA-2obeA:undetectable | 4obwA-2obeA:13.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2paj | PUTATIVECYTOSINE/GUANINEDEAMINASE (unidentified) |
PF01979(Amidohydro_1) | 5 | ALA A 392GLY A 393SER A 332ILE A 387GLY A 24 | None | 1.21A | 4obwA-2pajA:3.2 | 4obwA-2pajA:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vtc | CEL61B (Trichodermareesei) |
PF03443(Glyco_hydro_61) | 5 | ALA A 167GLY A 172GLY A 208ASN A 212PHE A 211 | None | 1.20A | 4obwA-2vtcA:undetectable | 4obwA-2vtcA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y05 | PROSTAGLANDINREDUCTASE 1 (Homo sapiens) |
PF00107(ADH_zinc_N)PF16884(ADH_N_2) | 5 | TYR A 214ALA A 172GLY A 171ASN A 217GLY A 174 | NoneNoneNoneNAP A 701 (-3.8A)NAP A 701 (-3.3A) | 0.99A | 4obwA-2y05A:7.9 | 4obwA-2y05A:25.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ylz | PHENYLACETONEMONOOXYGENASE (Thermobifidafusca) |
PF13738(Pyr_redox_3) | 5 | ASN A 58GLY A 198SER A 196ILE A 192GLY A 190 | FAD A 700 (-4.2A)NoneSO4 A1543 (-4.6A)NoneNone | 1.06A | 4obwA-2ylzA:undetectable | 4obwA-2ylzA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cj1 | ECTONUCLEOSIDETRIPHOSPHATEDIPHOSPHOHYDROLASE 2 (Rattusnorvegicus) |
PF01150(GDA1_CD39) | 5 | ALA A 123GLY A 124SER A 83ASN A 129GLY A 162 | None | 0.96A | 4obwA-3cj1A:undetectable | 4obwA-3cj1A:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clk | TRANSCRIPTIONREGULATOR (Lactobacillusplantarum) |
PF13377(Peripla_BP_3) | 5 | ALA A 184GLY A 185ILE A 216GLY A 182PHE A 233 | None | 1.04A | 4obwA-3clkA:2.9 | 4obwA-3clkA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3a | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF01301(Glyco_hydro_35) | 5 | ASN A 216ALA A 185GLY A 184GLY A 474PHE A 473 | None | 1.18A | 4obwA-3d3aA:undetectable | 4obwA-3d3aA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eo3 | BIFUNCTIONALUDP-N-ACETYLGLUCOSAMINE2-EPIMERASE/N-ACETYLMANNOSAMINE KINASE (Homo sapiens) |
PF00480(ROK) | 5 | ASN A 516ALA A 524GLY A 708MET A 712GLY A 529 | None | 1.22A | 4obwA-3eo3A:undetectable | 4obwA-3eo3A:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fpl | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Clostridiumbeijerinckii;Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 242GLY A 174ILE A 240GLY A 155ASN A 264 | None | 1.24A | 4obwA-3fplA:7.7 | 4obwA-3fplA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7s | LONG-CHAIN-FATTY-ACID--COA LIGASE(FADD-1) (Archaeoglobusfulgidus) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | ASN A 84ALA A 232GLY A 235ILE A 332GLY A 334 | None | 1.26A | 4obwA-3g7sA:undetectable | 4obwA-3g7sA:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hid | ADENYLOSUCCINATESYNTHETASE (Yersinia pestis) |
PF00709(Adenylsucc_synt) | 5 | ASN A 39ALA A 137GLY A 135SER A 241GLY A 146 | None | 1.15A | 4obwA-3hidA:2.2 | 4obwA-3hidA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjr | EXTRACELLULAR SERINEPROTEASE (Aeromonassobria) |
PF00082(Peptidase_S8)PF01483(P_proprotein) | 5 | ALA A 453GLY A 456SER A 385ASN A 556GLY A 583 | None | 1.18A | 4obwA-3hjrA:undetectable | 4obwA-3hjrA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrd | NICOTINATEDEHYDROGENASE MEDIUMMOLYBDOPTERINSUBUNIT (Eubacteriumbarkeri) |
PF02738(Ald_Xan_dh_C2) | 5 | ALA B 25GLY B 160ILE B 92ASN B 95GLY B 81 | None | 1.22A | 4obwA-3hrdB:undetectable | 4obwA-3hrdB:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i9v | NADH-QUINONEOXIDOREDUCTASESUBUNIT 1 (Thermusthermophilus) |
PF01512(Complex1_51K)PF10531(SLBB)PF10589(NADH_4Fe-4S) | 5 | ASN 1 343GLY 1 99SER 1 295ILE 1 254GLY 1 262 | NoneFES 2 182 ( 4.8A)NoneNoneNone | 0.99A | 4obwA-3i9v1:2.6 | 4obwA-3i9v1:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR CWF17 (Schizosaccharomycespombe) |
PF00400(WD40) | 5 | ASN L 85GLY L 68SER L 67GLY L 94ASN L 90 | None | 1.25A | 4obwA-3jb9L:undetectable | 4obwA-3jb9L:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khk | TYPE IRESTRICTION-MODIFICATION SYSTEMMETHYLATION SUBUNIT (Methanosarcinamazei) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 5 | TYR A 226ASN A 432GLY A 253SER A 254ASN A 291 | None | 1.23A | 4obwA-3khkA:11.8 | 4obwA-3khkA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khp | MAOC FAMILY PROTEIN (Mycobacteriumtuberculosis) |
PF01575(MaoC_dehydratas)PF13452(MaoC_dehydrat_N) | 5 | ALA A 67GLY A 65GLY A 71ASN A 74PHE A 73 | None | 0.99A | 4obwA-3khpA:undetectable | 4obwA-3khpA:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l8k | DIHYDROLIPOYLDEHYDROGENASE (Sulfolobussolfataricus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ALA A 13GLY A 305ILE A 135MET A 294GLY A 9 | ADP A 465 (-3.2A)ADP A 465 (-3.3A)NoneNoneADP A 465 (-3.4A) | 1.26A | 4obwA-3l8kA:2.6 | 4obwA-3l8kA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lpd | ACIDIC EXTRACELLULARSUBTILISIN-LIKEPROTEASE APRV2 (Dichelobacternodosus) |
PF00082(Peptidase_S8) | 5 | ALA A 124GLY A 125ASN A 53GLY A 122ASN A 118 | NoneNoneNone CA A 1 ( 4.3A)None | 1.14A | 4obwA-3lpdA:2.5 | 4obwA-3lpdA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6i | L-ARABINITOL4-DEHYDROGENASE (Neurosporacrassa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | TYR A 309ASN A 120GLY A 171ILE A 194GLY A 192 | None | 1.22A | 4obwA-3m6iA:8.3 | 4obwA-3m6iA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mpp | BOTULINUM NEUROTOXINTYPE G (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 5 | ALA G 869SER G 883ILE G1069GLY G1071ASN G 936 | None | 1.09A | 4obwA-3mppG:undetectable | 4obwA-3mppG:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8q | SHIKIMATE5-DEHYDROGENASE IALPHA (Vibrio cholerae) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 5 | ASN B 90ALA B 250GLY B 247ILE B 266GLY B 262 | None | 1.22A | 4obwA-3o8qB:2.2 | 4obwA-3o8qB:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ovg | AMIDOHYDROLASE (Mycoplasmasynoviae) |
PF02126(PTE) | 5 | GLY A 11ILE A 94ASN A 92GLY A 150PHE A 328 | None | 1.14A | 4obwA-3ovgA:undetectable | 4obwA-3ovgA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pxn | KINESIN-LIKE PROTEINNOD (Drosophilamelanogaster) |
PF00225(Kinesin) | 5 | GLY A 252SER A 255ILE A 249ASN A 248GLY A 229 | None | 0.99A | 4obwA-3pxnA:undetectable | 4obwA-3pxnA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qvm | OLEI00960 (Oleispiraantarctica) |
PF00561(Abhydrolase_1) | 5 | TYR A 61ASN A 18ALA A 84GLY A 82ILE A 109 | None | 1.25A | 4obwA-3qvmA:3.2 | 4obwA-3qvmA:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s1s | RESTRICTIONENDONUCLEASE BPUSI (Bacilluspumilus) |
PF02384(N6_Mtase)PF15516(BpuSI_N) | 5 | ALA A 329GLY A 331SER A 332ILE A 356PHE A 447 | SAH A 900 (-3.2A)SAH A 900 (-3.2A)SAH A 900 (-2.6A)SAH A 900 (-3.8A)None | 1.20A | 4obwA-3s1sA:11.5 | 4obwA-3s1sA:14.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrb | FLAVOPROTEIN SUBUNITOF COMPLEX II (Ascaris suum) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | ASN A 252ALA A 52GLY A 50ILE A 233GLY A 445 | FAD A 702 ( 3.7A)FAD A 702 (-4.0A)FAD A 702 (-3.0A)NoneNone | 0.98A | 4obwA-3vrbA:undetectable | 4obwA-3vrbA:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vsv | XYLOSIDASE (Thermoanaerobacteriumsaccharolyticum) |
PF13229(Beta_helix) | 5 | TYR A 494ASN A 495ILE A 424ASN A 426GLY A 440 | None | 1.06A | 4obwA-3vsvA:undetectable | 4obwA-3vsvA:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wfz | LACTO-N-BIOSEPHOSPHORYLASE (Bifidobacteriumlongum) |
PF09508(Lact_bio_phlase)PF17385(LBP_M)PF17386(LBP_C) | 5 | ASN A 720GLY A 340SER A 478ILE A 394GLY A 357 | None | 1.22A | 4obwA-3wfzA:undetectable | 4obwA-3wfzA:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wtb | PUTATIVEOXIDOREDUCTASE (Gluconobacteroxydans) |
PF13561(adh_short_C2) | 5 | TYR A 135ALA A 167GLY A 232ILE A 175GLY A 171 | None | 1.11A | 4obwA-3wtbA:6.7 | 4obwA-3wtbA:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a6u | OMEGA TRANSAMINASE (Chromobacteriumviolaceum) |
PF00202(Aminotran_3) | 5 | ALA A 287GLY A 120SER A 121ILE A 262GLY A 264 | None | 1.23A | 4obwA-4a6uA:undetectable | 4obwA-4a6uA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ap3 | STEROIDMONOOXYGENASE (Rhodococcusrhodochrous) |
PF00743(FMO-like) | 5 | ASN A 63GLY A 203SER A 201ILE A 197GLY A 195 | FAD A1552 (-4.4A)NoneNAP A1553 (-2.9A)NoneNone | 1.01A | 4obwA-4ap3A:2.1 | 4obwA-4ap3A:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3i | FATTY ACIDBETA-OXIDATIONCOMPLEX BETA-CHAINFADA (Mycobacteriumtuberculosis) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA C 366GLY C 95SER C 94ASN C 327GLY C 370 | None | 1.13A | 4obwA-4b3iC:undetectable | 4obwA-4b3iC:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3i | FATTY ACIDBETA-OXIDATIONCOMPLEX BETA-CHAINFADA (Mycobacteriumtuberculosis) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA C 366GLY C 95SER C 94ILE C 368GLY C 370 | None | 1.14A | 4obwA-4b3iC:undetectable | 4obwA-4b3iC:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cql | ESTRADIOL17-BETA-DEHYDROGENASE 8 (Homo sapiens) |
PF13561(adh_short_C2) | 5 | ALA A 184GLY A 250SER A 196ILE A 192GLY A 188 | None | 1.26A | 4obwA-4cqlA:7.3 | 4obwA-4cqlA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d5r | A49 (Vaccinia virus) |
PF06489(Orthopox_A49R) | 5 | GLY A 134SER A 135ILE A 47ASN A 44ASN A 49 | None | 1.22A | 4obwA-4d5rA:undetectable | 4obwA-4d5rA:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4haq | GH7 FAMILY PROTEIN (Limnoriaquadripunctata) |
PF00840(Glyco_hydro_7) | 5 | TYR A 68ASN A 66ASN A 54GLY A 126ASN A 221 | None | 1.25A | 4obwA-4haqA:undetectable | 4obwA-4haqA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jrm | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Vibrio cholerae) |
no annotation | 5 | ASN D 170ILE D 149ASN D 146GLY D 152ASN D 157 | None | 1.23A | 4obwA-4jrmD:undetectable | 4obwA-4jrmD:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l4y | TRANSCRIPTIONALREGULATOR LSRR (Escherichiacoli) |
PF04198(Sugar-bind) | 5 | TYR A 156GLY A 125ILE A 207MET A 129GLY A 281 | None | 1.25A | 4obwA-4l4yA:5.6 | 4obwA-4l4yA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mi4 | SPERMIDINEN1-ACETYLTRANSFERASE (Vibrio cholerae) |
PF13302(Acetyltransf_3) | 5 | ALA A 90ILE A 88GLY A 69ASN A 20PHE A 17 | None | 0.96A | 4obwA-4mi4A:2.8 | 4obwA-4mi4A:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o6v | OXIDOREDUCTASE,SHORT-CHAINDEHYDROGENASE/REDUCTASE FAMILY (Brucella suis) |
PF13561(adh_short_C2) | 5 | ALA A 11SER A 55ILE A 9GLY A 17ASN A 81 | None | 1.26A | 4obwA-4o6vA:6.5 | 4obwA-4o6vA:25.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4obw | 2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOLMETHYLASE,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF01209(Ubie_methyltran) | 12 | TYR A 78ASN A 82LYS A 94ALA A 119GLY A 120SER A 122ILE A 149ASN A 150MET A 153GLY A 180ASN A 202PHE A 203 | SAM A 602 (-3.9A)SAM A 602 ( 4.2A)SAM A 602 (-3.3A)SAM A 602 (-3.2A)SAM A 602 (-3.4A)SAM A 602 (-3.1A)SAM A 602 (-3.8A)SAM A 602 (-4.9A)SAM A 602 (-3.7A)SAM A 602 (-3.5A)SAM A 602 ( 4.9A)SAM A 602 (-3.9A) | 0.04A | 4obwA-4obwA:43.8 | 4obwA-4obwA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4obw | 2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOLMETHYLASE,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF01209(Ubie_methyltran) | 7 | TYR A 78GLY A 121SER A 122ILE A 149ASN A 150GLY A 180ASN A 202 | SAM A 602 (-3.9A)NoneSAM A 602 (-3.1A)SAM A 602 (-3.8A)SAM A 602 (-4.9A)SAM A 602 (-3.5A)SAM A 602 ( 4.9A) | 1.10A | 4obwA-4obwA:43.8 | 4obwA-4obwA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oc9 | PUTATIVEO-ACETYLHOMOSERINE(THIOL)-LYASE (Campylobacterjejuni) |
PF01053(Cys_Met_Meta_PP) | 5 | ALA A 217GLY A 216SER A 82ILE A 78GLY A 65 | NoneNoneLLP A 205 ( 3.7A)NoneNone | 1.18A | 4obwA-4oc9A:3.0 | 4obwA-4oc9A:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wem | ANTI-F4+ETECBACTERIA VHHVARIABLE REGION (Lama glama) |
PF07686(V-set) | 5 | GLY B 901SER B 898ILE B 851GLY B 855ASN B 858 | None | 1.22A | 4obwA-4wemB:undetectable | 4obwA-4wemB:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wr2 | PYRIMIDINE-SPECIFICRIBONUCLEOSIDEHYDROLASE RIHA (Shewanellaloihica) |
PF01156(IU_nuc_hydro) | 5 | ALA A 199GLY A 234ILE A 213ASN A 212MET A 196 | 1PE A 402 ( 4.4A)NoneNone CA A 401 ( 4.4A)None | 1.24A | 4obwA-4wr2A:undetectable | 4obwA-4wr2A:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x0o | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 PROTEIN 2 (Vibrio cholerae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | ASN A 110GLY A 312ILE A 190GLY A 216PHE A 214 | NoneSCY A 113 ( 3.1A)NoneNoneNone | 1.20A | 4obwA-4x0oA:undetectable | 4obwA-4x0oA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x68 | BETA-LACTAMASE (Pseudomonasaeruginosa) |
PF00144(Beta-lactamase) | 5 | ALA A 367GLY A 350SER A 345GLY A 53ASN A 49 | NoneNoneOP0 A 401 (-4.6A)NoneNone | 1.10A | 4obwA-4x68A:undetectable | 4obwA-4x68A:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xn3 | TAIL SPIKE PROTEIN (Salmonellavirus HK620) |
no annotation | 5 | ASN A 315ALA A 287GLY A 289ILE A 310GLY A 285 | NAG A1004 (-3.1A)NoneNoneNoneNone | 1.25A | 4obwA-4xn3A:undetectable | 4obwA-4xn3A:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z9r | OMEGA-3POLYUNSATURATEDFATTY ACID SYNTHASESUBUNIT PFAD (Shewanellaoneidensis) |
PF03060(NMO) | 5 | LYS A 294ALA A 311GLY A 310ILE A 315GLY A 313 | NoneNoneNoneNoneFMN A 602 (-3.4A) | 0.98A | 4obwA-4z9rA:undetectable | 4obwA-4z9rA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b04 | TRANSLATIONINITIATION FACTOREIF-2B SUBUNIT ALPHA (Schizosaccharomycespombe) |
PF01008(IF-2B) | 5 | ALA A 81GLY A 82ILE A 77ASN A 76GLY A 213 | None | 1.09A | 4obwA-5b04A:2.6 | 4obwA-5b04A:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e84 | 78 KDAGLUCOSE-REGULATEDPROTEIN (Homo sapiens) |
PF00012(HSP70) | 5 | GLY A 216ILE A 220ASN A 219GLY A 210PHE A 242 | None | 1.24A | 4obwA-5e84A:undetectable | 4obwA-5e84A:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5evi | BETA-LACTAMASE/D-ALANINECARBOXYPEPTIDASE (Pseudomonassyringae groupgenomosp. 3) |
PF00144(Beta-lactamase) | 5 | ALA B 338GLY B 321SER B 316GLY B 26ASN B 22 | MLY B 340 ( 4.0A)MLY B 340 ( 3.1A)NoneNoneNone | 1.08A | 4obwA-5eviB:undetectable | 4obwA-5eviB:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ewx | ENDOLYSIN,IMMUNOGLOBULIN G-BINDINGPROTEIN A,ENDOLYSIN (Staphylococcusaureus;Escherichiavirus T4) |
PF00959(Phage_lysozyme)PF02216(B) | 5 | TYR A 161ILE A 3MET A 1ASN A 101PHE A 104 | None | 1.20A | 4obwA-5ewxA:undetectable | 4obwA-5ewxA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5exe | OXALATEOXIDOREDUCTASESUBUNIT BETA (Moorellathermoacetica) |
PF02775(TPP_enzyme_C) | 5 | ALA C 113GLY C 111SER C 149GLY C 77PHE C 133 | None5SR C 402 (-3.4A)NoneNoneNone | 1.26A | 4obwA-5exeC:2.9 | 4obwA-5exeC:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fav | CHOLINETRIMETHYLAMINE-LYASE (Desulfovibrioalaskensis) |
PF01228(Gly_radical)PF02901(PFL-like) | 5 | GLY A 726SER A 724ILE A 700ASN A 702GLY A 821 | None | 1.25A | 4obwA-5favA:undetectable | 4obwA-5favA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmg | PROTEASOME SUBUNITALPHA, PUTATIVE (Plasmodiumfalciparum) |
PF00227(Proteasome)PF10584(Proteasome_A_N) | 5 | GLY A 144SER A 143ILE A 75ASN A 74GLY A 83 | None | 1.11A | 4obwA-5fmgA:undetectable | 4obwA-5fmgA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fya | PATATIN-LIKEPROTEIN, PLPD (Pseudomonasaeruginosa) |
PF01734(Patatin) | 5 | ASN A 234GLY A 208SER A 60ILE A 168GLY A 171 | None | 1.07A | 4obwA-5fyaA:2.4 | 4obwA-5fyaA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gs7 | CHOLOYLGLYCINEHYDROLASE (Enterococcusfaecalis) |
PF02275(CBAH) | 5 | ASN A 170ALA A 76GLY A 77GLY A 74PHE A 14 | None | 1.25A | 4obwA-5gs7A:undetectable | 4obwA-5gs7A:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hzl | LMO2445 PROTEIN (Listeriamonocytogenes) |
no annotation | 5 | ALA B 155GLY B 156SER B 158ILE B 113GLY B 110 | NoneNonePG5 B 408 ( 4.2A)NoneNone | 1.26A | 4obwA-5hzlB:undetectable | 4obwA-5hzlB:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jvk | UNCHARACTERIZEDPROTEIN (Bacteroidescellulosilyticus) |
no annotation | 5 | TYR A 311ALA A 294GLY A 286SER A 285GLY A 330 | NoneNoneNoneNoneSO4 A 651 (-3.3A) | 1.20A | 4obwA-5jvkA:undetectable | 4obwA-5jvkA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lv9 | THERMOPHILICTRYPTOPHANHALOGENASE (Streptomycesviolaceusniger) |
PF04820(Trp_halogenase) | 5 | ALA A 13GLY A 349SER A 352ILE A 7GLY A 10 | None | 1.20A | 4obwA-5lv9A:4.1 | 4obwA-5lv9A:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mln | ALCOHOLDEHYDROGENASE 3 ([Candida]magnoliae) |
no annotation | 5 | TYR A 141ALA A 172GLY A 230ILE A 180GLY A 176 | None | 1.25A | 4obwA-5mlnA:6.4 | 4obwA-5mlnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sz8 | HEMOLYSIN (Proteusmirabilis) |
PF05860(Haemagg_act) | 5 | ASN A 96ALA A 92GLY A 93ASN A 47GLY A 77 | None | 1.23A | 4obwA-5sz8A:undetectable | 4obwA-5sz8A:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ti8 | AMINOTRANSFERASE (Pseudomonas sp.M1) |
PF00202(Aminotran_3) | 5 | ALA A 289GLY A 122SER A 123ILE A 264GLY A 266 | None | 1.19A | 4obwA-5ti8A:undetectable | 4obwA-5ti8A:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u9p | GLUCONATE5-DEHYDROGENASE (Burkholderiacenocepacia) |
PF13561(adh_short_C2) | 5 | TYR A 161GLY A 98ILE A 24GLY A 23ASN A 199 | TLA A 302 ( 4.0A)NAP A 301 (-3.8A)NAP A 301 (-3.9A)NAP A 301 (-3.5A)TLA A 302 ( 3.0A) | 1.17A | 4obwA-5u9pA:7.2 | 4obwA-5u9pA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ug4 | SPERMIDINEN(1)-ACETYLTRANSFERASE (Vibrio cholerae) |
PF13302(Acetyltransf_3) | 5 | ALA A 90ILE A 88GLY A 69ASN A 20PHE A 17 | None | 1.08A | 4obwA-5ug4A:3.9 | 4obwA-5ug4A:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uyt | ICE-BINDING PROTEIN (Flavobacteriaceaebacterium3519-10) |
no annotation | 5 | ALA A 77GLY A 76GLY A 55ASN A 32PHE A 33 | None | 1.17A | 4obwA-5uytA:undetectable | 4obwA-5uytA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5voh | NADH OXIDASE (Lactobacillusbrevis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | TYR A 318ALA A 277GLY A 304ASN A 299GLY A 112 | NoneNoneNoneNoneFAD A 501 (-2.6A) | 1.25A | 4obwA-5vohA:undetectable | 4obwA-5vohA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xmb | PANTOTHENATE KINASE (Mycobacteriumtuberculosis) |
no annotation | 5 | ALA A 96GLY A 97SER A 98ASN A 204GLY A 94 | None | 1.12A | 4obwA-5xmbA:undetectable | 4obwA-5xmbA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zi9 | CYTOKININ RIBOSIDE5'-MONOPHOSPHATEPHOSPHORIBOHYDROLASE (Streptomycescoelicolor) |
no annotation | 5 | ASN A 144SER A 130GLY A 64ASN A 152PHE A 153 | None | 1.20A | 4obwA-5zi9A:undetectable | 4obwA-5zi9A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b4o | GLUTATHIONEREDUCTASE (Enterococcusfaecalis) |
no annotation | 5 | ASN A 99GLY A 12ILE A 314GLY A 317ASN A 20 | NoneFAD A 501 (-3.3A)NoneNone CL A 504 (-4.2A) | 1.25A | 4obwA-6b4oA:2.1 | 4obwA-6b4oA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bj9 | ACETYL-COAACETYLTRANSFERASE A (Ascaris suum) |
no annotation | 5 | ALA A 355GLY A 94SER A 93ASN A 316GLY A 359 | None | 1.16A | 4obwA-6bj9A:undetectable | 4obwA-6bj9A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bj9 | ACETYL-COAACETYLTRANSFERASE A (Ascaris suum) |
no annotation | 5 | ALA A 355GLY A 94SER A 93ILE A 357GLY A 359 | None | 1.12A | 4obwA-6bj9A:undetectable | 4obwA-6bj9A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gct | NEUTRAL AMINO ACIDTRANSPORTER B(0) (Homo sapiens) |
no annotation | 5 | TYR A 325ALA A 479GLY A 478ASN A 484ASN A 368 | None | 1.01A | 4obwA-6gctA:undetectable | 4obwA-6gctA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b1y | PROTEIN(BETA-AMYLASE) (Hordeum vulgare) |
PF01373(Glyco_hydro_14) | 3 | ASP A 214ASN A 139SER A 265 | None | 0.82A | 4obwA-1b1yA:undetectable | 4obwA-1b1yA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b43 | PROTEIN (FEN-1) (Pyrococcusfuriosus) |
PF00752(XPG_N)PF00867(XPG_I) | 3 | ASP A 235ASN A 237SER A 175 | None | 0.86A | 4obwA-1b43A:undetectable | 4obwA-1b43A:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d3b | PROTEIN (SMALLNUCLEARRIBONUCLEOPROTEIN SMD3)PROTEIN (SMALLNUCLEARRIBONUCLEOPROTEINASSOCIATED PROTEINB) (Homo sapiens;Homo sapiens) |
PF01423(LSM)PF01423(LSM) | 3 | ASP B 23ASN A 23SER B 79 | GOL B 608 ( 2.9A)GOL B 608 (-3.4A)None | 0.75A | 4obwA-1d3bB:undetectable | 4obwA-1d3bB:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dbh | PROTEIN (HUMAN SOS1) (Homo sapiens) |
PF00169(PH)PF00621(RhoGEF) | 3 | ASP A 241ASN A 233SER A 313 | None | 0.53A | 4obwA-1dbhA:undetectable | 4obwA-1dbhA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dtp | DIPHTHERIA TOXIN (Corynephagebeta) |
PF02763(Diphtheria_C) | 3 | ASP A 49ASN A 98SER A 109 | None | 0.74A | 4obwA-1dtpA:undetectable | 4obwA-1dtpA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ecg | GLUTAMINEPHOSPHORIBOSYLPYROPHOSPHATEAMIDOTRANSFERASE (Escherichiacoli) |
PF00156(Pribosyltran)PF13522(GATase_6) | 3 | ASP A 408ASN A 103SER A 81 | NoneONL A 505 (-4.4A)None | 0.46A | 4obwA-1ecgA:4.4 | 4obwA-1ecgA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ee2 | ALCOHOLDEHYDROGENASE (Equus caballus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | ASP A 226ASN A 241SER A 363 | None | 0.77A | 4obwA-1ee2A:7.5 | 4obwA-1ee2A:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ei6 | PHOSPHONOACETATEHYDROLASE (Pseudomonasfluorescens) |
PF01663(Phosphodiest) | 3 | ASP A 397ASN A 404SER A 70 | None | 0.81A | 4obwA-1ei6A:undetectable | 4obwA-1ei6A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fob | BETA-1,4-GALACTANASE (Aspergillusaculeatus) |
PF07745(Glyco_hydro_53) | 3 | ASP A 187ASN A 233SER A 221 | None | 0.74A | 4obwA-1fobA:undetectable | 4obwA-1fobA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hjq | BETA-1,4-GALACTANASE (Humicolainsolens) |
PF07745(Glyco_hydro_53) | 3 | ASP A 186ASN A 232SER A 220 | None | 0.85A | 4obwA-1hjqA:undetectable | 4obwA-1hjqA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hjq | BETA-1,4-GALACTANASE (Humicolainsolens) |
PF07745(Glyco_hydro_53) | 3 | ASP A 224ASN A 231SER A 279 | None | 0.71A | 4obwA-1hjqA:undetectable | 4obwA-1hjqA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1igr | INSULIN-LIKE GROWTHFACTOR RECEPTOR 1 (Homo sapiens) |
PF00757(Furin-like)PF01030(Recep_L_domain) | 3 | ASP A 405ASN A 408SER A 427 | None | 0.81A | 4obwA-1igrA:undetectable | 4obwA-1igrA:17.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j9l | STATIONARY PHASESURVIVAL PROTEIN (Thermotogamaritima) |
PF01975(SurE) | 3 | ASP A 73ASN A 80SER A 111 | None | 0.86A | 4obwA-1j9lA:2.2 | 4obwA-1j9lA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mqq | ALPHA-D-GLUCURONIDASE (Geobacillusstearothermophilus) |
PF03648(Glyco_hydro_67N)PF07477(Glyco_hydro_67C)PF07488(Glyco_hydro_67M) | 3 | ASP A 429ASN A 471SER A 422 | None | 0.79A | 4obwA-1mqqA:2.0 | 4obwA-1mqqA:16.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n7u | ADSORPTION PROTEINP2 (Salmonellavirus PRD1) |
PF09214(Prd1-P2) | 3 | ASP A 132ASN A 142SER A 62 | None | 0.76A | 4obwA-1n7uA:undetectable | 4obwA-1n7uA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ot5 | KEXIN (Saccharomycescerevisiae) |
PF00082(Peptidase_S8)PF01483(P_proprotein) | 3 | ASP A 184ASN A 228SER A 378 | CA A 601 (-2.3A)NoneNone | 0.85A | 4obwA-1ot5A:2.2 | 4obwA-1ot5A:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p3w | CYSTEINE DESULFURASE (Escherichiacoli) |
no annotation | 3 | ASP B 180ASN B 80SER B 100 | PLP B 764 (-2.8A)NoneNone | 0.83A | 4obwA-1p3wB:4.3 | 4obwA-1p3wB:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1po0 | IRON(III) DICITRATETRANSPORT PROTEINFECA PRECURSOR (Escherichiacoli) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 3 | ASP A 654ASN A 707SER A 657 | None | 0.84A | 4obwA-1po0A:undetectable | 4obwA-1po0A:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pqs | CELL DIVISIONCONTROL PROTEIN 24 (Saccharomycescerevisiae) |
PF00564(PB1) | 3 | ASP A 792ASN A 799SER A 830 | None | 0.71A | 4obwA-1pqsA:undetectable | 4obwA-1pqsA:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q0p | COMPLEMENT FACTOR B (Homo sapiens) |
PF00092(VWA) | 3 | ASP A 251ASN A 260SER A 326 | MN A 500 ( 4.0A)NoneNone | 0.73A | 4obwA-1q0pA:undetectable | 4obwA-1q0pA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qho | ALPHA-AMYLASE (Geobacillusstearothermophilus) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 3 | ASP A 283ASN A 280SER A 353 | None | 0.81A | 4obwA-1qhoA:undetectable | 4obwA-1qhoA:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qle | CYTOCHROME C OXIDASEPOLYPEPTIDE I-BETA (Paracoccusdenitrificans) |
PF00115(COX1) | 3 | ASP A 528ASN A 521SER A 291 | None | 0.86A | 4obwA-1qleA:undetectable | 4obwA-1qleA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rmg | RHAMNOGALACTURONASEA (Aspergillusaculeatus) |
PF00295(Glyco_hydro_28) | 3 | ASP A 279ASN A 247SER A 254 | None | 0.66A | 4obwA-1rmgA:undetectable | 4obwA-1rmgA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u2z | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-79SPECIFIC (Saccharomycescerevisiae) |
PF08123(DOT1) | 3 | ASP A 397ASN A 404SER A 455 | SAH A 801 (-3.0A)SAH A 801 ( 4.9A)None | 0.77A | 4obwA-1u2zA:9.3 | 4obwA-1u2zA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1udq | RIBONUCLEASE PH (Aquifexaeolicus) |
PF01138(RNase_PH)PF03725(RNase_PH_C) | 3 | ASP A 174ASN A 188SER A 31 | NonePO4 A 701 ( 4.8A)None | 0.83A | 4obwA-1udqA:undetectable | 4obwA-1udqA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uf2 | CORE PROTEIN P3 (Rice dwarfvirus) |
PF09231(RDV-p3) | 3 | ASP A 661ASN A 612SER A 305 | None | 0.58A | 4obwA-1uf2A:undetectable | 4obwA-1uf2A:12.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ukc | ESTA (Aspergillusniger) |
PF00135(COesterase) | 3 | ASP A 300ASN A 358SER A 392 | None | 0.67A | 4obwA-1ukcA:undetectable | 4obwA-1ukcA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vg0 | RAB PROTEINSGERANYLGERANYLTRANSFERASE COMPONENT A 1 (Rattusnorvegicus) |
PF00996(GDI) | 3 | ASP A 433ASN A 46SER A 437 | None | 0.80A | 4obwA-1vg0A:undetectable | 4obwA-1vg0A:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vi1 | FATTYACID/PHOSPHOLIPIDSYNTHESIS PROTEINPLSX (Bacillussubtilis) |
PF02504(FA_synthesis) | 3 | ASP A 139ASN A 229SER A 283 | None | 0.85A | 4obwA-1vi1A:2.7 | 4obwA-1vi1A:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w1k | VANILLYL-ALCOHOLOXIDASE (Penicilliumsimplicissimum) |
PF01565(FAD_binding_4)PF02913(FAD-oxidase_C) | 3 | ASP A 415ASN A 474SER A 50 | None | 0.87A | 4obwA-1w1kA:undetectable | 4obwA-1w1kA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xdv | SON OF SEVENLESSPROTEIN HOMOLOG 1 (Homo sapiens) |
PF00169(PH)PF00617(RasGEF)PF00618(RasGEF_N)PF00621(RhoGEF) | 3 | ASP A 241ASN A 233SER A 313 | None | 0.52A | 4obwA-1xdvA:undetectable | 4obwA-1xdvA:13.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xnt | PROTEIN (DNA-REPAIRPROTEIN XRCC1) (Homo sapiens) |
PF01834(XRCC1_N) | 3 | ASP A 63ASN A 23SER A 140 | None | 0.76A | 4obwA-1xntA:undetectable | 4obwA-1xntA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ybe | NICOTINATEPHOSPHORIBOSYLTRANSFERASE (Agrobacteriumtumefaciens) |
PF04095(NAPRTase) | 3 | ASP A 290ASN A 411SER A 344 | None | 0.80A | 4obwA-1ybeA:undetectable | 4obwA-1ybeA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ygg | PHOSPHOENOLPYRUVATECARBOXYKINASE (Actinobacillussuccinogenes) |
PF01293(PEPCK_ATP) | 3 | ASP A 93ASN A 186SER A 86 | None | 0.81A | 4obwA-1yggA:undetectable | 4obwA-1yggA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvm | TOXIN B (Clostridioidesdifficile) |
PF12918(TcdB_N)PF12919(TcdA_TcdB) | 3 | ASP A 109ASN A 116SER A 228 | None | 0.77A | 4obwA-2bvmA:undetectable | 4obwA-2bvmA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dul | N(2),N(2)-DIMETHYLGUANOSINE TRNAMETHYLTRANSFERASE (Pyrococcushorikoshii) |
PF02005(TRM) | 3 | ASP A 138ASN A 29SER A 142 | None | 0.86A | 4obwA-2dulA:12.8 | 4obwA-2dulA:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e47 | TIME INTERVALMEASURING ENZYMETIME (Bombyx mori) |
PF00080(Sod_Cu) | 3 | ASP A 87ASN A 90SER A 66 | ZN A 172 (-2.4A)NoneNone | 0.75A | 4obwA-2e47A:undetectable | 4obwA-2e47A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f6a | COLLAGEN ADHESIN (Staphylococcusaureus) |
PF05737(Collagen_bind) | 3 | ASP A 40ASN A 155SER A 126 | None | 0.84A | 4obwA-2f6aA:undetectable | 4obwA-2f6aA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fff | PENICILLIN-BINDINGPROTEIN 1B (Streptococcuspneumoniae) |
PF00905(Transpeptidase) | 3 | ASP B 337ASN B 449SER B 400 | None | 0.69A | 4obwA-2fffB:undetectable | 4obwA-2fffB:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fff | PENICILLIN-BINDINGPROTEIN 1B (Streptococcuspneumoniae) |
PF00905(Transpeptidase) | 3 | ASP B 337ASN B 449SER B 404 | None | 0.79A | 4obwA-2fffB:undetectable | 4obwA-2fffB:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fzw | ALCOHOLDEHYDROGENASE CLASSIII CHI CHAIN (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | ASP A 226ASN A 241SER A 363 | None | 0.85A | 4obwA-2fzwA:6.8 | 4obwA-2fzwA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gf2 | 3-HYDROXYISOBUTYRATEDEHYDROGENASE (Homo sapiens) |
PF03446(NAD_binding_2)PF14833(NAD_binding_11) | 3 | ASP A 285ASN A 212SER A 133 | None | 0.82A | 4obwA-2gf2A:3.0 | 4obwA-2gf2A:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h4t | CARNITINEO-PALMITOYLTRANSFERASE II, MITOCHONDRIAL (Rattusnorvegicus) |
PF00755(Carn_acyltransf) | 3 | ASP A 232ASN A 230SER A 126 | None | 0.80A | 4obwA-2h4tA:undetectable | 4obwA-2h4tA:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i54 | PHOSPHOMANNOMUTASE (Leishmaniamexicana) |
PF03332(PMM) | 3 | ASP A 10ASN A 70SER A 210 | MG A2002 (-2.8A)NoneNone | 0.78A | 4obwA-2i54A:undetectable | 4obwA-2i54A:25.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iny | HEXON PROTEIN (Fowlaviadenovirus A) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 3 | ASP A 484ASN A 437SER A 810 | None | 0.83A | 4obwA-2inyA:undetectable | 4obwA-2inyA:13.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iqj | STROMALMEMBRANE-ASSOCIATEDPROTEIN 1-LIKE (Homo sapiens) |
PF01412(ArfGap) | 3 | ASP A 71ASN A 69SER A 40 | None | 0.84A | 4obwA-2iqjA:undetectable | 4obwA-2iqjA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iye | COPPER-TRANSPORTINGATPASE (Sulfolobussolfataricus) |
PF00702(Hydrolase) | 3 | ASP A 546ASN A 563SER A 516 | None | 0.75A | 4obwA-2iyeA:3.3 | 4obwA-2iyeA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iyf | OLEANDOMYCINGLYCOSYLTRANSFERASE (Streptomycesantibioticus) |
PF00201(UDPGT) | 3 | ASP A 329ASN A 133SER A 75 | ERY A1400 (-4.7A)ERY A1400 (-3.6A)None | 0.85A | 4obwA-2iyfA:4.0 | 4obwA-2iyfA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j0j | FOCAL ADHESIONKINASE 1 (Gallus gallus) |
PF00373(FERM_M)PF07714(Pkinase_Tyr) | 3 | ASP A 200ASN A 193SER A 601 | None | 0.87A | 4obwA-2j0jA:undetectable | 4obwA-2j0jA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kbe | ATP-DEPENDENT RNAHELICASE DBP5 (Saccharomycescerevisiae) |
PF00270(DEAD) | 3 | ASP A 239ASN A 243SER A 138 | None | 0.84A | 4obwA-2kbeA:3.8 | 4obwA-2kbeA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lcu | BC28.1 (Babesia canis) |
no annotation | 3 | ASP A 148ASN A 144SER A 135 | None | 0.80A | 4obwA-2lcuA:undetectable | 4obwA-2lcuA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nya | PERIPLASMIC NITRATEREDUCTASE (Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 3 | ASP A 137ASN A 134SER A 777 | None | 0.83A | 4obwA-2nyaA:3.2 | 4obwA-2nyaA:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o57 | PUTATIVE SARCOSINEDIMETHYLGLYCINEMETHYLTRANSFERASE (Galdieriasulphuraria) |
PF08241(Methyltransf_11) | 3 | ASP A 31ASN A 267SER A 258 | None | 0.77A | 4obwA-2o57A:17.1 | 4obwA-2o57A:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qua | EXTRACELLULAR LIPASE (Serratiamarcescens) |
no annotation | 3 | ASP A 276ASN A 255SER A 367 | CA A 620 (-2.1A)NoneNone | 0.81A | 4obwA-2quaA:3.2 | 4obwA-2quaA:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r7y | RIBONUCLEASE H (Bacillushalodurans) |
no annotation | 3 | ASP A 163ASN A 170SER A 147 | None | 0.87A | 4obwA-2r7yA:undetectable | 4obwA-2r7yA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v4x | CAPSID PROTEIN P27 (Jaagsiektesheepretrovirus) |
PF00607(Gag_p24) | 3 | ASP A 106ASN A 110SER A 13 | None | 0.81A | 4obwA-2v4xA:undetectable | 4obwA-2v4xA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vjh | PHYCOERYTHRIN BETASUBUNIT (Gloeobacterviolaceus) |
PF00502(Phycobilisome) | 3 | ASP B 54ASN B 47SER B 132 | PUB B1050 (-3.0A)NoneNone | 0.86A | 4obwA-2vjhB:undetectable | 4obwA-2vjhB:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vl8 | CYTOTOXIN L (Paeniclostridiumsordellii) |
PF12918(TcdB_N)PF12919(TcdA_TcdB) | 3 | ASP A 109ASN A 116SER A 228 | None | 0.85A | 4obwA-2vl8A:undetectable | 4obwA-2vl8A:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w38 | SIALIDASE (Pseudomonasaeruginosa) |
PF13088(BNR_2) | 3 | ASP A 79ASN A 181SER A 299 | None | 0.82A | 4obwA-2w38A:undetectable | 4obwA-2w38A:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xyd | ANGIOTENSIN-CONVERTING ENZYME (Homo sapiens) |
PF01401(Peptidase_M2) | 3 | ASP A 43ASN A 45SER A 35 | NoneNAG A1614 (-1.9A)None | 0.85A | 4obwA-2xydA:undetectable | 4obwA-2xydA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y7b | ACTIN-BINDINGPROTEIN ANILLIN (Homo sapiens) |
PF00169(PH) | 3 | ASP A1096ASN A1103SER A1088 | None | 0.72A | 4obwA-2y7bA:undetectable | 4obwA-2y7bA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a9c | TRANSLATIONINITIATION FACTOREIF-2B, DELTASUBUNIT (Thermococcuskodakarensis) |
PF01008(IF-2B) | 3 | ASP A 89ASN A 44SER A 86 | None | 0.87A | 4obwA-3a9cA:5.9 | 4obwA-3a9cA:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3act | CELLOBIOSEPHOSPHORYLASE (Cellulomonasgilvus) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 3 | ASP A 422ASN A 489SER A 418 | None | 0.87A | 4obwA-3actA:undetectable | 4obwA-3actA:13.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3afg | SUBTILISIN-LIKESERINE PROTEASE (Thermococcuskodakarensis) |
PF00082(Peptidase_S8)PF04151(PPC) | 3 | ASP A 230ASN A 266SER A 223 | None | 0.73A | 4obwA-3afgA:2.1 | 4obwA-3afgA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aj6 | MAIN HEMAGGLUTININCOMPONENT (Clostridiumbotulinum) |
no annotation | 3 | ASP A 271ASN A 215SER A 260 | None | 0.75A | 4obwA-3aj6A:undetectable | 4obwA-3aj6A:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3akf | PUTATIVE SECRETEDALPHAL-ARABINOFURANOSIDASE II (Streptomycesavermitilis) |
PF04616(Glyco_hydro_43)PF05270(AbfB) | 3 | ASP A 135ASN A 195SER A 262 | GOL A 591 (-3.0A)NoneNone | 0.74A | 4obwA-3akfA:undetectable | 4obwA-3akfA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c0b | CONSERVED ARCHAEALPROTEIN Q6M145 (Methanococcusmaripaludis) |
PF01968(Hydantoinase_A) | 3 | ASP A 140ASN A 266SER A 136 | None | 0.80A | 4obwA-3c0bA:undetectable | 4obwA-3c0bA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cnc | FIBER PROTEIN (HumanmastadenovirusB) |
PF00541(Adeno_knob) | 3 | ASP A 283ASN A 321SER A 266 | None | 0.83A | 4obwA-3cncA:undetectable | 4obwA-3cncA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3czm | L-LACTATEDEHYDROGENASE (Toxoplasmagondii) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 3 | ASP A 111ASN A 140SER A 103 | NoneOXQ A 708 ( 3.4A)None | 0.83A | 4obwA-3czmA:4.8 | 4obwA-3czmA:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d43 | SPHERICASE (Lysinibacillussphaericus) |
PF00082(Peptidase_S8) | 3 | ASP A 67ASN A 240SER A 108 | None | 0.55A | 4obwA-3d43A:undetectable | 4obwA-3d43A:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fdh | SUSD HOMOLOG (Bacteroidesthetaiotaomicron) |
PF12771(SusD-like_2) | 3 | ASP A 61ASN A 57SER A 94 | None | 0.67A | 4obwA-3fdhA:undetectable | 4obwA-3fdhA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g2f | BONE MORPHOGENETICPROTEIN RECEPTORTYPE-2 (Homo sapiens) |
PF00069(Pkinase) | 3 | ASP A 405ASN A 338SER A 375 | None MG A 901 ( 2.8A)None | 0.82A | 4obwA-3g2fA:undetectable | 4obwA-3g2fA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hzt | CALCIUM-DEPENDENTPROTEIN KINASE 3 (Toxoplasmagondii) |
PF00069(Pkinase)PF13499(EF-hand_7) | 3 | ASP A 398ASN A 395SER A 451 | MG A 601 (-2.8A)NoneNone | 0.79A | 4obwA-3hztA:undetectable | 4obwA-3hztA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i6r | DIHYDROOROTATEDEHYDROGENASEHOMOLOG,MITOCHONDRIAL (Plasmodiumfalciparum) |
PF01180(DHO_dh) | 3 | ASP A 433ASN A 435SER A 485 | None | 0.71A | 4obwA-3i6rA:undetectable | 4obwA-3i6rA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3imh | GALACTOSE-1-EPIMERASE (Lactobacillusacidophilus) |
PF01263(Aldose_epim) | 3 | ASP A 292ASN A 280SER A 51 | MG A 337 ( 4.0A)NoneNone | 0.83A | 4obwA-3imhA:undetectable | 4obwA-3imhA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j9o | INTRACELLULAR GROWTHLOCUS PROTEIN B (Francisellatularensis) |
PF05943(VipB) | 3 | ASP B 276ASN B 261SER B 282 | None | 0.68A | 4obwA-3j9oB:undetectable | 4obwA-3j9oB:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kmh | D-LYXOSE ISOMERASE (Escherichiacoli) |
PF07385(Lyx_isomer) | 3 | ASP A 194ASN A 197SER A 77 | None | 0.74A | 4obwA-3kmhA:undetectable | 4obwA-3kmhA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ksy | SON OF SEVENLESSHOMOLOG 1 (Homo sapiens) |
PF00125(Histone)PF00169(PH)PF00617(RasGEF)PF00618(RasGEF_N)PF00621(RhoGEF) | 3 | ASP A 241ASN A 233SER A 313 | None | 0.86A | 4obwA-3ksyA:undetectable | 4obwA-3ksyA:12.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kxf | SB27 T CELL RECEPTORALPHA CHAIN (Homo sapiens) |
PF07686(V-set)PF09291(DUF1968) | 3 | ASP D 153ASN D 192SER D 183 | None | 0.77A | 4obwA-3kxfD:undetectable | 4obwA-3kxfD:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l0z | PUTATIVENICOTINATE-NUCLEOTIDE-DIMETHYLBENZIMIDAZOLEPHOSPHORIBOSYLTRANSFERASE (Methanocaldococcusjannaschii) |
PF02277(DBI_PRT) | 3 | ASP A 111ASN A 125SER A 28 | None | 0.87A | 4obwA-3l0zA:undetectable | 4obwA-3l0zA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lmk | METABOTROPICGLUTAMATE RECEPTOR 5 (Homo sapiens) |
PF01094(ANF_receptor) | 3 | ASP A 309ASN A 483SER A 304 | None | 0.70A | 4obwA-3lmkA:2.8 | 4obwA-3lmkA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lrk | ALPHA-GALACTOSIDASE1 (Saccharomycescerevisiae) |
PF16499(Melibiase_2) | 3 | ASP A 149ASN A 153SER A 207 | GOL A7001 (-4.1A)NoneNone | 0.71A | 4obwA-3lrkA:undetectable | 4obwA-3lrkA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mue | PANTOTHENATESYNTHETASE (Salmonellaenterica) |
PF02569(Pantoate_ligase) | 3 | ASP A 276ASN A 206SER A 279 | None | 0.75A | 4obwA-3mueA:undetectable | 4obwA-3mueA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nhe | UBIQUITINCARBOXYL-TERMINALHYDROLASE 2 (Homo sapiens) |
PF00443(UCH) | 3 | ASP A 392ASN A 535SER A 421 | None | 0.86A | 4obwA-3nheA:undetectable | 4obwA-3nheA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o5a | PERIPLASMIC NITRATEREDUCTASE (Cupriavidusnecator) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 3 | ASP A 146ASN A 143SER A 787 | NoneNoneOCS A 784 ( 3.2A) | 0.76A | 4obwA-3o5aA:3.6 | 4obwA-3o5aA:15.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3of1 | CAMP-DEPENDENTPROTEIN KINASEREGULATORY SUBUNIT (Saccharomycescerevisiae) |
PF00027(cNMP_binding) | 3 | ASP A 364ASN A 411SER A 299 | None | 0.66A | 4obwA-3of1A:undetectable | 4obwA-3of1A:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3om9 | LACTATEDEHYDROGENASE (Toxoplasmagondii) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 3 | ASP A 111ASN A 140SER A 105 | NoneOXQ A 702 ( 3.2A)None | 0.47A | 4obwA-3om9A:3.8 | 4obwA-3om9A:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8a | UNCHARACTERIZEDPROTEIN (Staphylococcusaureus) |
PF13468(Glyoxalase_3) | 3 | ASP A 160ASN A 109SER A 206 | None | 0.83A | 4obwA-3p8aA:undetectable | 4obwA-3p8aA:24.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p9u | TETX2 PROTEIN (Bacteroidesthetaiotaomicron) |
PF01494(FAD_binding_3) | 3 | ASP A 330ASN A 337SER A 66 | None | 0.77A | 4obwA-3p9uA:2.7 | 4obwA-3p9uA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pg8 | PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATEALDOLASE (Thermotogamaritima) |
PF00793(DAHP_synth_1) | 3 | ASP A 269ASN A 248SER A 313 | None | 0.75A | 4obwA-3pg8A:undetectable | 4obwA-3pg8A:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3c | PROBABLE3-HYDROXYISOBUTYRATEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF03446(NAD_binding_2)PF14833(NAD_binding_11) | 3 | ASP A 247ASN A 174SER A 95 | NAD A 299 (-3.8A)NoneNone | 0.81A | 4obwA-3q3cA:5.1 | 4obwA-3q3cA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qlb | ENANTIO-PYOCHELINRECEPTOR (Pseudomonasfluorescens) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 3 | ASP A 362ASN A 343SER A 138 | None | 0.58A | 4obwA-3qlbA:undetectable | 4obwA-3qlbA:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rdn | ANTIFREEZE PROTEINRD3 TYPE III (Lycodichthysdearborni) |
no annotation | 3 | ASP A 58ASN A 46SER A 69 | None | 0.84A | 4obwA-3rdnA:undetectable | 4obwA-3rdnA:15.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ri6 | O-ACETYLHOMOSERINESULFHYDRYLASE (Wolinellasuccinogenes) |
PF01053(Cys_Met_Meta_PP) | 3 | ASP A 180ASN A 155SER A 203 | None | 0.74A | 4obwA-3ri6A:3.0 | 4obwA-3ri6A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rof | LOW MOLECULAR WEIGHTPROTEIN-TYROSINE-PHOSPHATASE PTPA (Staphylococcusaureus) |
PF01451(LMWPc) | 3 | ASP A 120ASN A 125SER A 15 | PO4 A 201 (-2.8A)NoneNone | 0.84A | 4obwA-3rofA:3.7 | 4obwA-3rofA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3saj | GLUTAMATE RECEPTOR 1 (Rattusnorvegicus) |
PF01094(ANF_receptor) | 3 | ASP A 185ASN A 158SER A 188 | None | 0.78A | 4obwA-3sajA:4.0 | 4obwA-3sajA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sns | LIPOPROTEIN 34 (Escherichiacoli) |
PF06804(Lipoprotein_18) | 3 | ASP A 229ASN A 312SER A 232 | None | 0.87A | 4obwA-3snsA:undetectable | 4obwA-3snsA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u95 | GLYCOSIDE HYDROLASE,FAMILY 4 (Thermotoganeapolitana) |
PF02056(Glyco_hydro_4)PF11975(Glyco_hydro_4C) | 3 | ASP A 294ASN A 121SER A 96 | None | 0.81A | 4obwA-3u95A:4.0 | 4obwA-3u95A:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ugg | SUCROSE:(SUCROSE/FRUCTAN)6-FRUCTOSYLTRANSFERASE (Pachysandraterminalis) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 3 | ASP A 451ASN A 521SER A 421 | NoneNAG A 553 (-1.8A)None | 0.84A | 4obwA-3uggA:undetectable | 4obwA-3uggA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va7 | KLLA0E08119P (Kluyveromyceslactis) |
PF00289(Biotin_carb_N)PF00364(Biotin_lipoyl)PF02626(CT_A_B)PF02682(CT_C_D)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 3 | ASP A 849ASN A 867SER A 956 | None | 0.87A | 4obwA-3va7A:3.3 | 4obwA-3va7A:11.50 |