SIMILAR PATTERNS OF AMINO ACIDS FOR 4OAE_A_CLMA207

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 PRO A 129
ALA A 153
ASN A 163
GLY A 193
LEU A 196
 None
 1.05A 4oaeA-1bh6A:
undetectable		 4oaeA-1bh6A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 ALA A 176
ASN A 163
ALA A 194
GLY A 193
LEU A 196
 CA  A 284 ( 4.3A)
None
None
None
None
 0.91A 4oaeA-1c3lA:
undetectable		 4oaeA-1c3lA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		5 PRO A 108
ALA A 409
ALA A 416
GLY A 417
LEU A 420
 None
 1.04A 4oaeA-1c4kA:
undetectable		 4oaeA-1c4kA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		5 PRO L  59
ALA L  88
ALA L  80
GLY L 419
LEU L 429
 None
 1.01A 4oaeA-1cc1L:
undetectable		 4oaeA-1cc1L:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		5 ALA A  42
ARG A  81
ALA A 279
GLY A 233
LEU A 231
 None
 1.05A 4oaeA-1cj0A:
undetectable		 4oaeA-1cj0A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		6 PHE A 318
PRO A 346
ALA A 315
ALA A 323
ALA A 293
GLY A 268
 None
 1.30A 4oaeA-1dabA:
undetectable		 4oaeA-1dabA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		5 ALA A 252
ALA A 287
ALA A 259
GLY A 258
LEU A 260
 None
 1.09A 4oaeA-1dgmA:
undetectable		 4oaeA-1dgmA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89

(Zoogloea
ramigera) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLU A 198
ALA A 375
ALA A 355
GLY A 354
LEU A  93
 None
None
None
SCY  A  89 ( 4.6A)
None
 1.03A 4oaeA-1dm3A:
undetectable		 4oaeA-1dm3A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I

(Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 PRO A 171
ALA A  63
ARG A 445
ALA A 156
GLY A 157
 None
 1.01A 4oaeA-1i1qA:
undetectable		 4oaeA-1i1qA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu4 MICROBIAL
TRANSGLUTAMINASE

(Streptomyces
mobaraensis) 		PF09017
(Transglut_prok) 		5 PRO A  99
GLU A 103
ARG A 111
ALA A 113
GLY A 218
 None
 1.10A 4oaeA-1iu4A:
undetectable		 4oaeA-1iu4A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp2 ARGININOSUCCINATE
SYNTHETASE

(Escherichia
coli) 		PF00764
(Arginosuc_synth) 		5 GLU A  79
ALA A 107
ARG A 344
ALA A 340
ALA A  88
 None
 1.08A 4oaeA-1kp2A:
undetectable		 4oaeA-1kp2A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp2 ARGININOSUCCINATE
SYNTHETASE

(Escherichia
coli) 		PF00764
(Arginosuc_synth) 		5 GLU A  79
ARG A 344
ALA A 340
ALA A  88
GLY A 327
 None
 1.09A 4oaeA-1kp2A:
undetectable		 4oaeA-1kp2A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg7 EARLY SWITCH PROTEIN
XOL-1 2.2K SPLICE
FORM

(Caenorhabditis
elegans) 		PF09108
(Xol-1_N)
PF09109
(Xol-1_GHMP-like) 		5 PHE A 121
PRO A 124
ALA A 132
MET A 136
LEU A 183
 None
 1.08A 4oaeA-1mg7A:
undetectable		 4oaeA-1mg7A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvz YDR533C PROTEIN

(Saccharomyces
cerevisiae) 		PF01965
(DJ-1_PfpI) 		5 GLU A  50
ALA A   9
ALA A 142
GLY A 109
LEU A 111
 None
 0.94A 4oaeA-1qvzA:
undetectable		 4oaeA-1qvzA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sef CONSERVED
HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF05899
(Cupin_3)
PF07883
(Cupin_2) 		5 PRO A 238
ALA A  30
ALA A  60
GLY A  59
LEU A  58
 None
 0.96A 4oaeA-1sefA:
undetectable		 4oaeA-1sefA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		5 PHE A  18
ALA A 278
MET A 295
ALA A 300
LEU A 256
 None
 0.90A 4oaeA-1u60A:
undetectable		 4oaeA-1u60A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Pseudomonas
aeruginosa) 		PF05690
(ThiG) 		5 ALA A1231
MET A1228
ALA A1038
ALA A1044
GLY A1043
 None
 0.97A 4oaeA-1wv2A:
undetectable		 4oaeA-1wv2A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwk PHOSPHOGLYCERATE
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A   7
ARG A  69
ALA A  68
ALA A 290
GLY A 291
 None
 0.94A 4oaeA-1wwkA:
undetectable		 4oaeA-1wwkA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjt LYSOZYME

(Escherichia
virus P1) 		PF00959
(Phage_lysozyme) 		5 ALA A 105
ASN A  31
ALA A  33
GLY A  34
LEU A  37
 None
 1.01A 4oaeA-1xjtA:
undetectable		 4oaeA-1xjtA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xju LYSOZYME

(Escherichia
virus P1) 		PF00959
(Phage_lysozyme) 		5 ALA A 105
ASN A  31
ALA A  33
GLY A  34
LEU A  37
 None
 1.08A 4oaeA-1xjuA:
undetectable		 4oaeA-1xjuA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		5 ALA A 126
ALA A  56
ALA A  88
GLY A  87
LEU A  89
 None
 1.06A 4oaeA-1xw8A:
undetectable		 4oaeA-1xw8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE

(Pseudomonas
putida;
Spinacia
oleracea) 		PF01070
(FMN_dh) 		5 ALA A 110
ASN A 112
ALA A  85
GLY A  84
LEU A  86
 FMN  A 390 ( 4.5A)
None
None
None
None
 1.00A 4oaeA-2a7nA:
undetectable		 4oaeA-2a7nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb9 FENGYCIN SYNTHETASE

(Bacillus
subtilis) 		PF00975
(Thioesterase) 		5 PHE A  37
GLU A 206
ALA A 210
ALA A 200
GLY A 199
 None
 1.09A 4oaeA-2cb9A:
1.9		 4oaeA-2cb9A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195

(Thermus
thermophilus) 		PF03746
(LamB_YcsF) 		5 ALA A 131
ALA A  61
ALA A  93
GLY A  92
LEU A  94
 None
 1.05A 4oaeA-2dfaA:
undetectable		 4oaeA-2dfaA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		PF00076
(RRM_1) 		5 GLU A 207
ALA A 211
ALA A 171
GLY A 176
LEU A 175
 None
 0.95A 4oaeA-2g4bA:
undetectable		 4oaeA-2g4bA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jlm PUTATIVE
PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE

(Acinetobacter
baylyi) 		PF13420
(Acetyltransf_4) 		5 ALA A  37
ARG A 103
ASN A 135
ALA A 137
LEU A 141
 None
 0.80A 4oaeA-2jlmA:
18.2		 4oaeA-2jlmA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN

(Cyanothece) 		PF00805
(Pentapeptide) 		5 ARG A  59
ALA A  77
ASN A  53
GLY A  55
LEU A  56
 None
 1.06A 4oaeA-2o6wA:
undetectable		 4oaeA-2o6wA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana) 		PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 ALA A 482
ALA A 518
ALA A 464
GLY A 465
LEU A 468
 None
 1.04A 4oaeA-2o7qA:
undetectable		 4oaeA-2o7qA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		5 ALA A  50
ALA A 243
ALA A 203
GLY A  63
LEU A 238
 None
 1.08A 4oaeA-2ogaA:
undetectable		 4oaeA-2ogaA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)

(Homo sapiens) 		PF00215
(OMPdecase) 		5 GLU A 265
ALA A 258
ARG A 459
ALA A 463
ALA A 272
 None
 0.95A 4oaeA-2qcmA:
undetectable		 4oaeA-2qcmA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLU A 299
ALA A 301
ARG A 313
ALA A 316
LEU A 268
 None
 0.87A 4oaeA-2vpwA:
undetectable		 4oaeA-2vpwA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens) 		PF08933
(DUF1864) 		5 PHE A 162
ALA A 278
ALA A 298
GLY A 295
LEU A 296
 None
 1.10A 4oaeA-2x66A:
undetectable		 4oaeA-2x66A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu2 UPF0271 PROTEIN
PA4511

(Pseudomonas
aeruginosa) 		PF03746
(LamB_YcsF) 		5 ALA A 137
ALA A  67
ALA A  99
GLY A  98
LEU A 100
 None
 1.10A 4oaeA-2xu2A:
undetectable		 4oaeA-2xu2A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		PF00076
(RRM_1) 		5 GLU A 207
ALA A 211
ALA A 171
GLY A 176
LEU A 175
 None
 0.85A 4oaeA-2yh0A:
undetectable		 4oaeA-2yh0A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3h ENDOGLUCANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		5 PHE A 201
GLU A 139
ALA A 198
ALA A 260
ALA A  64
 None
CTR  A   1 ( 2.4A)
None
None
None
 1.05A 4oaeA-3a3hA:
undetectable		 4oaeA-3a3hA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3u MENAQUINONE
BIOSYNTHETIC ENZYME

(Thermus
thermophilus) 		PF02621
(VitK2_biosynth) 		5 GLU A 137
ALA A 134
ARG A 128
ALA A 100
GLY A 141
 None
 1.00A 4oaeA-3a3uA:
undetectable		 4oaeA-3a3uA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		5 GLU A 202
ALA A 204
ARG A 354
ALA A 256
GLY A 198
 None
 1.10A 4oaeA-3b05A:
undetectable		 4oaeA-3b05A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		5 PHE A  22
GLU A  20
ALA A 342
GLY A 419
LEU A 418
 None
 0.95A 4oaeA-3cskA:
undetectable		 4oaeA-3cskA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dv9 BETA-PHOSPHOGLUCOMUT
ASE

(Bacteroides
vulgatus) 		PF13419
(HAD_2) 		5 PHE A  25
GLU A 186
ALA A 182
ALA A 198
GLY A 199
 None
MG  A 301 ( 4.6A)
None
None
None
 1.08A 4oaeA-3dv9A:
undetectable		 4oaeA-3dv9A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eod PROTEIN HNR

(Escherichia
coli) 		PF00072
(Response_reg) 		5 PRO A  81
ARG A  74
ALA A  97
GLY A  66
LEU A  67
 None
 1.10A 4oaeA-3eodA:
undetectable		 4oaeA-3eodA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8u TAPASIN

(Homo sapiens) 		PF07654
(C1-set) 		5 GLU B 311
ALA B 323
ARG B 313
ALA B 358
GLY B 317
 None
 1.09A 4oaeA-3f8uB:
undetectable		 4oaeA-3f8uB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Listeria
innocua) 		PF00155
(Aminotran_1_2) 		5 GLU A 273
ALA A 264
ASN A  39
GLY A 225
LEU A 226
 None
 1.09A 4oaeA-3ffhA:
undetectable		 4oaeA-3ffhA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fii BOTULINUM NEUROTOXIN
TYPE F

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 ALA A 226
ASN A 101
ALA A 103
GLY A 104
LEU A 107
 None
 1.04A 4oaeA-3fiiA:
undetectable		 4oaeA-3fiiA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Streptomyces
mobaraensis) 		PF09017
(Transglut_prok) 		5 PRO A 145
GLU A 149
ARG A 157
ALA A 159
GLY A 264
 None
 1.04A 4oaeA-3iu0A:
undetectable		 4oaeA-3iu0A:
16.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kkw PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		11 PHE A  19
PRO A  20
GLU A  25
TYR A  28
MET A  82
ARG A  88
ALA A  93
ASN A 121
ALA A 123
GLY A 124
LEU A 127
 None
EDO  A 163 ( 4.2A)
EDO  A 177 ( 3.3A)
None
None
EDO  A 177 ( 3.5A)
SO4  A 162 (-3.2A)
EDO  A 174 (-3.2A)
None
EDO  A 174 (-3.6A)
SO4  A 162 (-3.9A)
 0.31A 4oaeA-3kkwA:
31.5		 4oaeA-3kkwA:
98.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksw STEROL 14-ALPHA
DEMETHYLASE

(Trypanosoma
cruzi) 		PF00067
(p450) 		5 GLU A 149
ALA A 179
ALA A 198
ALA A 173
GLY A 172
 None
 1.07A 4oaeA-3kswA:
undetectable		 4oaeA-3kswA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk7 23S RRNA
METHYLTRANSFERASE

(Streptomyces
actuosus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		5 ALA A 266
ARG A 260
ALA A 142
GLY A 141
LEU A 140
 None
 0.88A 4oaeA-3nk7A:
undetectable		 4oaeA-3nk7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pea ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00378
(ECH_1) 		5 GLU A 158
ALA A 156
ALA A 171
GLY A 129
LEU A 128
 None
 1.02A 4oaeA-3peaA:
1.6		 4oaeA-3peaA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quc INORGANIC
PYROPHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		5 PHE A  10
GLU A 171
ALA A 167
ALA A 183
GLY A 184
 None
 1.04A 4oaeA-3qucA:
undetectable		 4oaeA-3qucA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Shewanella
denitrificans) 		PF00465
(Fe-ADH) 		5 ALA A 146
MET A 103
ALA A 108
GLY A 162
LEU A 163
 NAD  A 358 (-3.7A)
None
None
CL  A 364 (-3.5A)
None
 1.04A 4oaeA-3rf7A:
undetectable		 4oaeA-3rf7A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc2 SERINE
CARBOXYPEPTIDASE II
(CPDW-II)

(Triticum
aestivum) 		PF00450
(Peptidase_S10) 		5 TYR B 348
ALA B 345
ALA B 352
GLY B 351
LEU B 353
 None
 0.96A 4oaeA-3sc2B:
undetectable		 4oaeA-3sc2B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Bacillus
anthracis) 		PF04321
(RmlD_sub_bind) 		5 ALA A 246
ARG A  73
ALA A  76
ALA A 129
GLY A 128
 None
 0.94A 4oaeA-3sc6A:
1.1		 4oaeA-3sc6A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sim PROTEIN, FAMILY 18
CHITINASE

(Crocus vernus) 		PF00704
(Glyco_hydro_18) 		5 PHE A 219
TYR A 190
ALA A 237
GLY A 201
LEU A 200
 None
 1.10A 4oaeA-3simA:
1.7		 4oaeA-3simA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 PHE A 573
ALA A 392
ALA A 131
GLY A 128
LEU A 129
 None
 1.07A 4oaeA-3uszA:
undetectable		 4oaeA-3uszA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		5 PRO B  64
ALA B  93
ALA B  85
GLY B 416
LEU B 426
 None
 0.98A 4oaeA-3ze7B:
undetectable		 4oaeA-3ze7B:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4o EPIMERASE FAMILY
PROTEIN SDR39U1

(Homo sapiens) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		5 PHE A 281
ALA A 292
ALA A 234
GLY A 233
LEU A 236
 None
 1.09A 4oaeA-4b4oA:
undetectable		 4oaeA-4b4oA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4z DEOXYHYPUSINE
HYDROXYLASE

(Homo sapiens) 		PF13646
(HEAT_2) 		5 PRO A 101
ALA A  70
ALA A  94
GLY A  63
LEU A  62
 None
 1.10A 4oaeA-4d4zA:
undetectable		 4oaeA-4d4zA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4z DEOXYHYPUSINE
HYDROXYLASE

(Homo sapiens) 		PF13646
(HEAT_2) 		5 PRO A 252
ALA A 221
ALA A 245
GLY A 214
LEU A 213
 None
 0.98A 4oaeA-4d4zA:
undetectable		 4oaeA-4d4zA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Sinorhizobium
meliloti) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 PRO A 185
ALA A 213
ALA A 240
GLY A 239
LEU A 238
 None
 1.03A 4oaeA-4dioA:
undetectable		 4oaeA-4dioA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 PRO A 548
TYR A 580
ALA A  76
ASN A 585
GLY A 583
 None
 1.07A 4oaeA-4epaA:
undetectable		 4oaeA-4epaA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 TYR A  46
ALA A  47
ALA A 236
GLY A 235
LEU A 237
 PHB  A 406 (-4.1A)
None
None
None
None
 1.05A 4oaeA-4evqA:
undetectable		 4oaeA-4evqA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3y DIHYDRODIPICOLINATE
REDUCTASE

(Burkholderia
thailandensis) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		5 TYR A 240
ALA A  22
ALA A 244
GLY A 243
LEU A 245
 None
 1.09A 4oaeA-4f3yA:
undetectable		 4oaeA-4f3yA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi2 CROTONYL-COA
CARBOXYLASE/REDUCTAS
E

(Methylobacterium
extorquens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 370
ALA A 196
ASN A 405
GLY A 222
LEU A 223
 None
None
MG  A 501 (-4.3A)
NAP  A 502 (-3.2A)
NAP  A 502 (-4.0A)
 1.05A 4oaeA-4gi2A:
undetectable		 4oaeA-4gi2A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 5 PHE A 443
TYR A 439
ALA A 202
ALA A 174
GLY A 173
 None
 1.06A 4oaeA-4j0kA:
1.3		 4oaeA-4j0kA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		5 ALA A 359
ARG A 362
ALA A 364
ALA A 342
GLY A 341
 None
 1.08A 4oaeA-4j0wA:
undetectable		 4oaeA-4j0wA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvx N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX CATALYTIC
SUBUNIT ARD1

(Schizosaccharomyces
pombe) 		PF00583
(Acetyltransf_1) 		5 ARG A  83
ALA A  88
ASN A 116
ALA A 118
LEU A 122
 ACO  A 201 (-3.7A)
ACO  A 201 (-3.3A)
ACO  A 201 (-3.1A)
ACO  A 201 (-3.4A)
ACO  A 201 (-3.7A)
 0.84A 4oaeA-4kvxA:
16.7		 4oaeA-4kvxA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Thermomonospora
curvata) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		5 ARG A 149
ALA A 147
ALA A 178
GLY A 177
LEU A 179
 None
 0.98A 4oaeA-4lrsA:
undetectable		 4oaeA-4lrsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)

(Candida
albicans) 		PF01965
(DJ-1_PfpI) 		5 GLU A  48
ALA A   7
ALA A 140
GLY A 107
LEU A 109
 None
 1.03A 4oaeA-4lruA:
undetectable		 4oaeA-4lruA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0x CHLOROMUCONATE
CYCLOISOMERASE

(Rhodococcus
opacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 PHE A 296
ALA A 294
ALA A 246
ALA A 256
LEU A 259
 None
 1.02A 4oaeA-4m0xA:
1.4		 4oaeA-4m0xA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		6 GLU A 235
ALA A 206
ARG A 229
ALA A 259
GLY A 203
LEU A 262
 None
None
None
None
GOL  A 301 (-4.7A)
None
 1.42A 4oaeA-4nbrA:
undetectable		 4oaeA-4nbrA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2h PROTEIN BCAM1869

(Burkholderia
cenocepacia) 		PF16245
(DUF4902) 		5 ALA A 102
ALA A  99
ALA A  24
GLY A  23
LEU A  25
 None
 1.03A 4oaeA-4o2hA:
undetectable		 4oaeA-4o2hA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 GLU A 284
ALA A 298
ARG A 278
ALA A 208
ALA A 313
 None
 1.07A 4oaeA-4p72A:
2.1		 4oaeA-4p72A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)

(Agrobacterium
fabrum) 		PF01547
(SBP_bac_1) 		5 GLU A 233
ARG A 175
ALA A 173
GLY A 186
LEU A 177
 None
 1.09A 4oaeA-4rjzA:
undetectable		 4oaeA-4rjzA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqt D-HYDANTOINASE

(Brucella suis) 		PF01979
(Amidohydro_1) 		5 GLU A  29
ALA A   6
ALA A 392
GLY A 435
LEU A 432
 None
 1.10A 4oaeA-4tqtA:
undetectable		 4oaeA-4tqtA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqt D-HYDANTOINASE

(Brucella suis) 		PF01979
(Amidohydro_1) 		5 TYR A 416
ALA A 407
ALA A  83
ALA A 320
GLY A 341
 None
 1.09A 4oaeA-4tqtA:
undetectable		 4oaeA-4tqtA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uar PROTEIN CBBY

(Rhodobacter
sphaeroides) 		PF13419
(HAD_2) 		5 PHE A   7
GLU A 175
ALA A 171
ALA A 187
GLY A 188
 None
 1.08A 4oaeA-4uarA:
undetectable		 4oaeA-4uarA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PRO A 373
ALA A 339
ALA A 408
GLY A 409
LEU A 412
 None
 0.89A 4oaeA-4udrA:
1.5		 4oaeA-4udrA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 PHE A 230
ALA A 238
ALA A 100
ALA A  93
GLY A  94
 TRP  A 601 (-4.4A)
TRP  A 601 ( 3.9A)
None
None
None
 1.10A 4oaeA-4us4A:
undetectable		 4oaeA-4us4A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		5 PRO A 180
ALA A 201
ALA A  63
GLY A 194
LEU A 193
 None
 1.10A 4oaeA-4wzbA:
undetectable		 4oaeA-4wzbA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)

(Mycobacterium
tuberculosis) 		PF01180
(DHO_dh) 		5 ALA A  80
ALA A 325
ALA A  60
GLY A  84
LEU A  62
 None
 1.00A 4oaeA-4xq6A:
undetectable		 4oaeA-4xq6A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)

(Candidatus
Korarchaeum
cryptofilum) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		5 TYR A 121
ALA A 118
ALA A  71
ALA A  90
GLY A  91
 None
 1.09A 4oaeA-4xz3A:
undetectable		 4oaeA-4xz3A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg5 5'-NUCLEOTIDASE SURE

(Brucella
abortus) 		no annotation 5 PHE D 167
PRO D 168
ALA D 223
ALA D  98
GLY D 184
 None
 0.92A 4oaeA-4zg5D:
undetectable		 4oaeA-4zg5D:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE

(Streptomyces
globisporus) 		PF00668
(Condensation) 		5 ALA A 373
ALA A 166
ALA A  48
GLY A  47
LEU A 150
 None
None
None
SUC  A 502 ( 4.8A)
None
 1.01A 4oaeA-4zxwA:
undetectable		 4oaeA-4zxwA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE

(Penicillium
cyclopium) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		5 TYR A 169
ALA A 170
ARG A 159
ALA A 154
LEU A  78
 None
 0.94A 4oaeA-5ch8A:
1.9		 4oaeA-5ch8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gam PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08082
(PRO8NT)
PF08083
(PROCN) 		5 PRO A 206
ALA A 171
ALA A 567
GLY A 568
LEU A 571
 None
 1.06A 4oaeA-5gamA:
undetectable		 4oaeA-5gamA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		5 PRO B 707
GLU B 708
ALA B 666
GLY B 795
LEU B 796
 None
 1.05A 4oaeA-5gjeB:
undetectable		 4oaeA-5gjeB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htp PROBABLE SUGAR
KINASE

(Synechococcus
elongatus) 		PF02782
(FGGY_C) 		5 ALA A  16
ALA A  67
ALA A 224
GLY A 406
LEU A 410
 None
 1.07A 4oaeA-5htpA:
undetectable		 4oaeA-5htpA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 PRO A 120
ALA A 148
ALA A 190
GLY A 189
LEU A 191
 None
None
None
FAD  A 701 (-4.1A)
None
 1.10A 4oaeA-5k3jA:
undetectable		 4oaeA-5k3jA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5z PARA

(Sulfolobus sp.
NOB8H2) 		PF13614
(AAA_31) 		5 PRO A 249
TYR A 241
ALA A 244
GLY A 202
LEU A 201
 None
 1.05A 4oaeA-5k5zA:
undetectable		 4oaeA-5k5zA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE

(Shewanella
oneidensis) 		PF00465
(Fe-ADH) 		5 ALA A 146
MET A 103
ALA A 108
GLY A 162
LEU A 163
 NAD  A 401 (-3.5A)
None
None
None
None
 1.02A 4oaeA-5k8cA:
undetectable		 4oaeA-5k8cA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF00583
(Acetyltransf_1) 		5 ARG B  92
ALA B  97
ASN B 125
ALA B 127
LEU B 131
 None
 0.87A 4oaeA-5nnpB:
15.5		 4oaeA-5nnpB:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PRO A 374
ALA A 152
ALA A  71
GLY A  70
LEU A  92
 None
 0.98A 4oaeA-5tnxA:
undetectable		 4oaeA-5tnxA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5us8 ARGININOSUCCINATE
SYNTHASE

(Bordetella
pertussis) 		PF00764
(Arginosuc_synth) 		5 MET A 343
ARG A 345
ALA A 348
ALA A  89
GLY A 324
 None
 0.92A 4oaeA-5us8A:
undetectable		 4oaeA-5us8A:
18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vdb ACETYLTRANSFERASE
PA4794

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		11 PHE A  19
PRO A  20
GLU A  25
TYR A  28
MET A  82
ARG A  88
ALA A  93
ASN A 121
ALA A 123
GLY A 124
LEU A 127
 None
None
93M  A 207 ( 3.9A)
93M  A 207 (-4.8A)
None
93M  A 207 (-3.7A)
93M  A 207 (-3.2A)
93M  A 207 (-3.0A)
93M  A 207 (-3.7A)
93M  A 207 ( 4.2A)
93M  A 207 (-3.5A)
 0.58A 4oaeA-5vdbA:
31.4		 4oaeA-5vdbA:
98.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w62 APOPTOSIS REGULATOR
BAX

(Mus musculus) 		no annotation 5 PHE A 105
ARG A 109
ALA A 112
GLY A 179
LEU A 181
 None
 1.09A 4oaeA-5w62A:
undetectable		 4oaeA-5w62A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 5 PHE A2374
TYR A2250
ALA A2264
ALA A2380
ALA A2397
 None
 1.06A 4oaeA-5y2aA:
undetectable		 4oaeA-5y2aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S8E
RIBOSOMAL PROTEIN
S17

(Leishmania
donovani;
Leishmania
donovani) 		no annotation
no annotation 		5 ALA K  68
ARG K 187
ASN U  32
GLY K 205
LEU K 208
 G  1 244 ( 3.5A)
None
None
None
None
 0.97A 4oaeA-6az1K:
undetectable		 4oaeA-6az1K:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteichus
tenebrarius) 		no annotation 5 PRO B 115
ALA B 108
ALA B  93
GLY B 125
LEU B  96
 None
 0.97A 4oaeA-6fd2B:
undetectable		 4oaeA-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 5 TYR C 241
ALA C 113
ALA C 245
GLY C 243
LEU C 246
 None
 1.10A 4oaeA-6fkhC:
undetectable		 4oaeA-6fkhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 5 PHE A 414
ARG A 387
ALA A 391
ALA A 427
GLY A 428
 None
 0.93A 4oaeA-6fylA:
undetectable		 4oaeA-6fylA:
undetectable