SIMILAR PATTERNS OF AMINO ACIDS FOR 4O8Z_A_BBIA402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 PHE A 127
PHE A 126
LEU A 119
PRO A 111
 None
 1.29A 4o8zA-1b3bA:
3.7		 4o8zA-1b3bA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 PHE A 425
PHE A 262
LEU A 333
PRO A 442
 PC1  A 778 (-4.7A)
None
None
None
 1.41A 4o8zA-1bp1A:
undetectable		 4o8zA-1bp1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		4 PHE A 321
HIS A 240
PHE A 323
LEU A 340
 None
FE2  A 629 (-3.3A)
None
None
 1.39A 4o8zA-1cjxA:
undetectable		 4o8zA-1cjxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e33 ARYLSULFATASE A

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		4 HIS P 226
PHE P 144
LEU P 197
PRO P 192
 None
 1.36A 4o8zA-1e33P:
undetectable		 4o8zA-1e33P:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpm GMP SYNTHETASE

(Escherichia
coli) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 PHE A 281
PHE A 277
LEU A 247
PRO A 375
 None
 1.43A 4o8zA-1gpmA:
3.6		 4o8zA-1gpmA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ll2 GLYCOGENIN-1

(Oryctolagus
cuniculus) 		PF01501
(Glyco_transf_8) 		4 PHE A 100
HIS A 212
PHE A 137
PRO A 126
 None
MN  A 333 ( 3.4A)
None
None
 1.37A 4o8zA-1ll2A:
2.1		 4o8zA-1ll2A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyq THREONYL-TRNA
SYNTHETASE 1

(Staphylococcus
aureus) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		4 PHE A 530
PHE A 527
LEU A 252
PRO A 545
 None
 0.76A 4o8zA-1nyqA:
undetectable		 4o8zA-1nyqA:
19.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q1a HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		4 HIS A 135
PHE A  67
LEU A 188
PRO A 230
 OAD  A1001 (-3.8A)
OAD  A1001 ( 4.6A)
None
None
 1.37A 4o8zA-1q1aA:
28.4		 4o8zA-1q1aA:
41.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q1a HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		4 PHE A  67
HIS A 135
LEU A 188
PRO A 230
 OAD  A1001 ( 4.6A)
OAD  A1001 (-3.8A)
None
None
 1.02A 4o8zA-1q1aA:
28.4		 4o8zA-1q1aA:
41.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		4 PHE A 314
HIS A 360
PHE A 316
PRO A 356
 None
 1.31A 4o8zA-1qfxA:
undetectable		 4o8zA-1qfxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgj PEROXIDASE N

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		4 PHE A 229
HIS A 165
LEU A 239
PRO A 137
 None
HEM  A1350 (-3.4A)
None
HEM  A1350 (-4.2A)
 1.41A 4o8zA-1qgjA:
undetectable		 4o8zA-1qgjA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo4 PEROXIDASE

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		4 PHE A 233
HIS A 169
LEU A 243
PRO A 141
 None
HEM  A 374 (-3.5A)
None
HEM  A 374 (-3.9A)
 1.40A 4o8zA-1qo4A:
undetectable		 4o8zA-1qo4A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7g NAD-DEPENDENT
DEACETYLASE 2

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		4 HIS A 118
PHE A 165
LEU A 169
PRO A 198
 NAD  A 703 ( 4.9A)
EDO  A 505 ( 4.0A)
None
None
 0.97A 4o8zA-1s7gA:
23.2		 4o8zA-1s7gA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		4 PHE A  82
HIS A  87
LEU A 475
PRO A 339
 None
 1.45A 4o8zA-1v4gA:
undetectable		 4o8zA-1v4gA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 318
PHE A 317
LEU A 294
PRO A 254
 None
 1.35A 4o8zA-1vzoA:
undetectable		 4o8zA-1vzoA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 HIS A 788
PHE A 711
LEU A 772
PRO A 742
 None
 1.25A 4o8zA-1yguA:
undetectable		 4o8zA-1yguA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE

(Sarocladium
strictum) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 PHE A 410
PHE A 385
LEU A 418
PRO A 324
 None
 1.36A 4o8zA-1zr6A:
undetectable		 4o8zA-1zr6A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 PHE A 513
PHE A 512
LEU A 488
PRO A 443
 None
 1.33A 4o8zA-1zrzA:
undetectable		 4o8zA-1zrzA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cso PLECKSTRIN

(Homo sapiens) 		PF00610
(DEP) 		4 PHE A  44
PHE A 108
LEU A  77
PRO A 100
 None
 1.33A 4o8zA-2csoA:
undetectable		 4o8zA-2csoA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gc1 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Pyrococcus
furiosus) 		PF06560
(GPI) 		4 HIS A 136
PHE A 148
LEU A 110
PRO A 131
 ZN  A 401 ( 3.3A)
None
None
None
 1.40A 4o8zA-2gc1A:
undetectable		 4o8zA-2gc1A:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		4 PHE A 296
HIS A 364
LEU A 449
PRO A 478
 None
XYQ  A1222 (-3.8A)
None
None
 0.98A 4o8zA-2hjhA:
25.9		 4o8zA-2hjhA:
32.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwj HYPOTHETICAL PROTEIN
ATU1540

(Agrobacterium
fabrum) 		PF08857
(ParBc_2) 		4 HIS A  69
PHE A 156
LEU A 131
PRO A 125
 None
 1.02A 4o8zA-2hwjA:
undetectable		 4o8zA-2hwjA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n47 SLR1183 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13649
(Methyltransf_25) 		4 PHE A 132
PHE A 102
LEU A 150
PRO A 144
 None
 1.03A 4o8zA-2n47A:
4.6		 4o8zA-2n47A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v91 STRICTOSIDINE
SYNTHASE

(Rauvolfia
serpentina) 		PF03088
(Str_synth) 		4 PHE A  55
PHE A  46
LEU A 331
PRO A 300
 None
 1.29A 4o8zA-2v91A:
undetectable		 4o8zA-2v91A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN

(Shigella
flexneri) 		PF00497
(SBP_bac_3) 		4 PHE A 247
PHE A 260
LEU A 256
PRO A 196
 None
 1.33A 4o8zA-2vhaA:
undetectable		 4o8zA-2vhaA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 PHE A 935
PHE A 937
LEU A 954
PRO A 942
 None
 1.33A 4o8zA-2vsqA:
undetectable		 4o8zA-2vsqA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1z ROP2

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		4 PHE A 323
HIS A 407
PHE A 325
PRO A 441
 None
 1.45A 4o8zA-2w1zA:
undetectable		 4o8zA-2w1zA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 291
PHE A 290
LEU A 272
PRO A 232
 None
 1.40A 4o8zA-2y7jA:
undetectable		 4o8zA-2y7jA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 PHE A 194
HIS A  96
PHE A 199
PRO A 426
 None
 1.21A 4o8zA-2yd0A:
undetectable		 4o8zA-2yd0A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		4 PHE A 298
PHE A 264
LEU A  85
PRO A 232
 None
 1.30A 4o8zA-2zktA:
undetectable		 4o8zA-2zktA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 PHE A 516
PHE A 482
LEU A 930
PRO A 494
 None
 1.12A 4o8zA-2zxqA:
undetectable		 4o8zA-2zxqA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 352
PHE A 351
LEU A 328
PRO A 292
 None
 1.28A 4o8zA-3a62A:
undetectable		 4o8zA-3a62A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1

(Aquifex
aeolicus) 		PF02005
(TRM) 		4 PHE A 213
PHE A 224
LEU A 194
PRO A 137
 None
 1.18A 4o8zA-3axsA:
undetectable		 4o8zA-3axsA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 5

(Thermus
thermophilus) 		PF00329
(Complex1_30kDa)
PF00346
(Complex1_49kDa) 		4 HIS 4  63
PHE 4  66
LEU 5 121
PRO 5 145
 None
 1.38A 4o8zA-3i9v4:
undetectable		 4o8zA-3i9v4:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyj MAJOR CAPSID PROTEIN
L1

(Deltapapillomavirus
4) 		no annotation 4 PHE F 441
PHE F 443
LEU F 226
PRO F 228
 None
 1.45A 4o8zA-3iyjF:
undetectable		 4o8zA-3iyjF:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP1
PROTEIN VP3

(Enterovirus B) 		PF00073
(Rhv) 		4 PHE A  53
PHE A 123
LEU B  25
PRO A  86
 None
 1.24A 4o8zA-3j2jA:
undetectable		 4o8zA-3j2jA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg7 CURH

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		4 HIS A 965
PHE A1123
LEU A 941
PRO A1132
 None
 1.43A 4o8zA-3kg7A:
undetectable		 4o8zA-3kg7A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		4 PHE A 436
HIS A 299
LEU A 313
PRO A 398
 None
 1.25A 4o8zA-3mzsA:
undetectable		 4o8zA-3mzsA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		4 PHE A 475
HIS A 338
LEU A 352
PRO A 437
 None
 1.24A 4o8zA-3na0A:
undetectable		 4o8zA-3na0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH) 		4 PHE A 408
PHE A 407
LEU A 384
PRO A 348
 PHE  A 408 ( 1.3A)
PHE  A 407 ( 1.3A)
LEU  A 384 ( 0.6A)
PRO  A 348 ( 1.1A)
 1.23A 4o8zA-3o96A:
undetectable		 4o8zA-3o96A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkm CAS6 PROTEIN

(Pyrococcus
furiosus) 		PF01881
(Cas_Cas6) 		4 PHE A 198
PHE A 238
LEU A 211
PRO A 157
 A  G   7 ( 4.7A)
None
None
None
 1.40A 4o8zA-3pkmA:
undetectable		 4o8zA-3pkmA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3u LIGNIN PEROXIDASE

(Trametopsis
cervina) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 PHE A 204
HIS A 175
LEU A 233
PRO A 147
 None
HEM  A 338 (-3.3A)
HEM  A 338 (-4.5A)
HEM  A 338 (-4.1A)
 1.38A 4o8zA-3q3uA:
undetectable		 4o8zA-3q3uA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyb TBC1 DOMAIN FAMILY
MEMBER 4

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 PHE A 975
HIS A1022
PHE A 981
LEU A 878
 None
 1.40A 4o8zA-3qybA:
undetectable		 4o8zA-3qybA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qye TBC1 DOMAIN FAMILY
MEMBER 1

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 PHE A 856
HIS A 903
PHE A 862
LEU A 758
 None
 1.42A 4o8zA-3qyeA:
undetectable		 4o8zA-3qyeA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r72 ODORANT BINDING
PROTEIN ASP5

(Apis mellifera) 		PF01395
(PBP_GOBP) 		4 PHE A  64
HIS A 112
PHE A  66
LEU A  73
 None
NBB  A   1 (-3.4A)
None
NBB  A   1 ( 3.9A)
 1.23A 4o8zA-3r72A:
undetectable		 4o8zA-3r72A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmv GLYCOGENIN-1

(Homo sapiens) 		PF01501
(Glyco_transf_8) 		4 PHE A 100
HIS A 212
PHE A 137
PRO A 126
 None
MN  A 263 ( 3.3A)
None
None
 1.30A 4o8zA-3rmvA:
undetectable		 4o8zA-3rmvA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
fragilis) 		PF10282
(Lactonase) 		4 PHE A 228
HIS A 203
LEU A 180
PRO A 178
 None
 1.26A 4o8zA-3scyA:
undetectable		 4o8zA-3scyA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdo NITRILOTRIACETATE
MONOOXYGENASE

(Burkholderia
pseudomallei) 		PF00296
(Bac_luciferase) 		4 PHE A  54
PHE A  52
LEU A 394
PRO A 271
 None
 1.37A 4o8zA-3sdoA:
undetectable		 4o8zA-3sdoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 PHE A 365
PHE A 389
LEU A  58
PRO A  34
 None
 1.26A 4o8zA-3tk3A:
undetectable		 4o8zA-3tk3A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uat DISKS LARGE HOMOLOG
1

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		4 PHE A 871
PHE A 875
LEU A 825
PRO A 723
 None
 1.31A 4o8zA-3uatA:
undetectable		 4o8zA-3uatA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue9 ADENYLOSUCCINATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF00709
(Adenylsucc_synt) 		4 PHE A  43
PHE A 230
LEU A  33
PRO A 445
 None
 1.42A 4o8zA-3ue9A:
undetectable		 4o8zA-3ue9A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpq GLUTATHIONE
S-TRANSFERASE SIGMA

(Bombyx mori) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 PHE A 129
PHE A 130
LEU A 137
PRO A 182
 PEG  A 306 ( 4.5A)
None
None
None
 1.13A 4o8zA-3vpqA:
undetectable		 4o8zA-3vpqA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN
PROTEIN SMG-7

(Caenorhabditis
elegans) 		PF10373
(EST1_DNA_bind)
no annotation 		4 PHE A  69
PHE A  72
LEU B  77
PRO B  23
 None
 1.41A 4o8zA-3zheA:
undetectable		 4o8zA-3zheA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5g ANIONIC PEROXIDASE

(Raphanus
sativus) 		PF00141
(peroxidase) 		4 PHE A 235
HIS A 171
LEU A 245
PRO A 143
 None
HEM  A1307 (-3.4A)
HEM  A1307 ( 4.7A)
HEM  A1307 (-4.1A)
 1.43A 4o8zA-4a5gA:
undetectable		 4o8zA-4a5gA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ar9 COLLAGENASE COLT

(Clostridium
tetani) 		PF01752
(Peptidase_M9) 		4 HIS A 601
PHE A 554
LEU A 605
PRO A 515
 None
 1.12A 4o8zA-4ar9A:
undetectable		 4o8zA-4ar9A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3v E1 ENVELOPE
GLYCOPROTEIN

(Rubella virus) 		PF05748
(Rubella_E1) 		4 PHE A 102
PHE A 123
LEU A 257
PRO A 278
 None
 1.34A 4o8zA-4b3vA:
undetectable		 4o8zA-4b3vA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4beg PHOSPHATIDYLETHANOLA
MINE BINDING PROTEIN

(Mycobacterium
tuberculosis) 		PF01161
(PBP) 		4 PHE A 160
HIS A 162
PHE A 157
LEU A 144
 None
 1.34A 4o8zA-4begA:
undetectable		 4o8zA-4begA:
23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		4 PHE A 180
HIS A 248
LEU A 298
PRO A 326
 SR7  A1396 (-3.7A)
SR7  A1396 ( 3.5A)
None
None
 0.76A 4o8zA-4bn5A:
39.1		 4o8zA-4bn5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		4 PHE A 180
HIS A 248
PHE A 294
LEU A 298
 SR7  A1396 (-3.7A)
SR7  A1396 ( 3.5A)
SR7  A1396 (-3.5A)
None
 0.60A 4o8zA-4bn5A:
39.1		 4o8zA-4bn5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 PHE A 916
PHE A 915
LEU A 892
PRO A 856
 None
 1.35A 4o8zA-4crsA:
undetectable		 4o8zA-4crsA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 PHE A 202
HIS A 173
LEU A 243
PRO A 144
 None
HEM  A1374 (-3.5A)
HEM  A1374 ( 4.7A)
HEM  A1374 (-4.1A)
 1.38A 4o8zA-4czpA:
undetectable		 4o8zA-4czpA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 PHE B  28
PHE B 120
LEU B  90
PRO B  81
 None
 1.45A 4o8zA-4gnkB:
undetectable		 4o8zA-4gnkB:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 PHE A 408
PHE A 407
LEU A 384
PRO A 348
 None
 1.27A 4o8zA-4gv1A:
undetectable		 4o8zA-4gv1A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2

(Mus musculus) 		PF03372
(Exo_endo_phos) 		4 PHE A 269
PHE A 329
LEU A 342
PRO A 300
 None
 1.46A 4o8zA-4gz2A:
undetectable		 4o8zA-4gz2A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Vibrio cholerae) 		PF04095
(NAPRTase) 		4 PHE A 321
HIS A 293
PHE A 339
LEU A 327
 None
 1.34A 4o8zA-4hl7A:
undetectable		 4o8zA-4hl7A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		4 PHE A 296
HIS A 364
LEU A 449
PRO A 478
 None
APR  A 602 (-4.1A)
None
None
 0.88A 4o8zA-4iaoA:
26.2		 4o8zA-4iaoA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldy AUXIN RESPONSE
FACTOR 1

(Arabidopsis
thaliana) 		PF02362
(B3)
PF06507
(Auxin_resp) 		4 HIS A 178
PHE A 139
LEU A 164
PRO A 151
 None
 1.37A 4o8zA-4ldyA:
undetectable		 4o8zA-4ldyA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		4 PHE A 453
PHE A 452
LEU A 429
PRO A 390
 None
 1.28A 4o8zA-4mk0A:
undetectable		 4o8zA-4mk0A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 PHE D  88
PHE D 148
LEU D 111
PRO D 122
 None
 1.35A 4o8zA-4ngeD:
undetectable		 4o8zA-4ngeD:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 PHE D 168
HIS D 254
PHE D 169
LEU D 172
 None
None
MLY  D 287 ( 4.5A)
None
 1.44A 4o8zA-4ngeD:
undetectable		 4o8zA-4ngeD:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nlm LMO1340 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 PHE A 257
PHE A 248
LEU A 244
PRO A 273
 None
 1.40A 4o8zA-4nlmA:
undetectable		 4o8zA-4nlmA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 PHE B 476
HIS B 243
LEU B 529
PRO B 538
 None
 1.16A 4o8zA-4ouaB:
undetectable		 4o8zA-4ouaB:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		4 PHE B  42
HIS B  48
LEU B  87
PRO B 351
 None
 1.30A 4o8zA-4tyhB:
undetectable		 4o8zA-4tyhB:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yci BONE MORPHOGENETIC
PROTEIN 9 GROWTH
FACTOR DOMAIN

(Mus musculus) 		PF00688
(TGFb_propeptide) 		4 PHE A 105
HIS A 108
LEU A 110
PRO A 229
 None
 1.46A 4o8zA-4yciA:
undetectable		 4o8zA-4yciA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv1 ANCQR

(synthetic
construct) 		PF00497
(SBP_bac_3) 		4 PHE A  23
PHE A  20
LEU A  32
PRO A  55
 None
ARG  A 301 (-3.4A)
None
None
 1.42A 4o8zA-4zv1A:
undetectable		 4o8zA-4zv1A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an8 TRPV2

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF12796
(Ank_2) 		4 HIS A 436
PHE A 405
LEU A 432
PRO A 413
 None
 1.31A 4o8zA-5an8A:
undetectable		 4o8zA-5an8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnz GLUTAMINE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 PHE A 521
PHE A 523
LEU A 381
PRO A 461
 None
 1.00A 4o8zA-5bnzA:
undetectable		 4o8zA-5bnzA:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 PHE A 297
HIS A 363
LEU A 418
PRO A 447
 None
 0.82A 4o8zA-5btrA:
28.5		 4o8zA-5btrA:
32.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE

(Streptomyces
coelicolor) 		no annotation 4 PHE A  84
HIS A 105
LEU A 159
PRO A 110
 None
 1.42A 4o8zA-5dz2A:
undetectable		 4o8zA-5dz2A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa1 PUTATIVE N-ACETYL
GLUCOSAMINYL
TRANSFERASE

(Raoultella
terrigena) 		PF05159
(Capsule_synth) 		4 PHE A 208
HIS A 205
LEU A 286
PRO A 214
 None
 1.40A 4o8zA-5fa1A:
2.8		 4o8zA-5fa1A:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2

(Homo sapiens) 		PF02146
(SIR2) 		4 PHE A 119
HIS A 187
LEU A 239
PRO A 268
 None
 1.14A 4o8zA-5fyqA:
31.0		 4o8zA-5fyqA:
44.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hi9 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF12796
(Ank_2) 		4 HIS A 438
PHE A 407
LEU A 434
PRO A 415
 None
 0.90A 4o8zA-5hi9A:
undetectable		 4o8zA-5hi9A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 PHE A 259
PHE A 319
LEU A 334
PRO A 290
 None
 1.39A 4o8zA-5j3pA:
undetectable		 4o8zA-5j3pA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans) 		PF03055
(RPE65) 		4 PHE A 248
PHE A 310
LEU A 475
PRO A  45
 None
None
V55  A 503 ( 3.3A)
V55  A 503 ( 4.8A)
 1.34A 4o8zA-5j55A:
undetectable		 4o8zA-5j55A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 PHE A 211
HIS A 111
PHE A 216
PRO A 443
 None
 1.37A 4o8zA-5j6sA:
undetectable		 4o8zA-5j6sA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvv BETA-1,3-GLUCOSYLTRA
NSFERASE

(Paecilomyces
sp.
'thermophila') 		no annotation 4 PHE B 227
HIS B 135
LEU B 159
PRO B 113
 None
 1.18A 4o8zA-5jvvB:
undetectable		 4o8zA-5jvvB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m23 WD REPEAT-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40) 		4 PHE A 263
PHE A 219
LEU A 234
PRO A 216
 7DC  A 401 (-3.9A)
None
None
None
 1.44A 4o8zA-5m23A:
undetectable		 4o8zA-5m23A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2

(Leishmania
infantum) 		no annotation 4 PHE A  74
HIS A 144
LEU A 194
PRO A 223
 None
 0.95A 4o8zA-5ol0A:
31.1		 4o8zA-5ol0A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trw PYRIDOXAL KINASE
PDXY

(Paraburkholderia
xenovorans) 		PF08543
(Phos_pyr_kin) 		4 PHE A 242
PHE A 228
LEU A 223
PRO A  25
 None
 1.45A 4o8zA-5trwA:
5.1		 4o8zA-5trwA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		4 PHE A 223
HIS A 249
LEU A 199
PRO A 356
 None
 1.40A 4o8zA-5tulA:
2.9		 4o8zA-5tulA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulj RAI1

(Scheffersomyces
stipitis) 		PF08652
(RAI1) 		4 PHE A  25
PHE A  23
LEU A 244
PRO A  19
 None
 0.82A 4o8zA-5uljA:
undetectable		 4o8zA-5uljA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 PHE A 453
PHE A 452
LEU A 429
PRO A 390
 None
 1.25A 4o8zA-5uuuA:
undetectable		 4o8zA-5uuuA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 4 PHE B 427
HIS B 418
LEU A 461
PRO A 459
 None
 1.43A 4o8zA-5y58B:
3.8		 4o8zA-5y58B:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysq TM0415

(Thermotoga
maritima) 		no annotation 4 PHE A 121
HIS A 112
PHE A 143
LEU A 169
 None
 1.44A 4o8zA-5ysqA:
4.6		 4o8zA-5ysqA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT

(Thermococcus
kodakarensis) 		no annotation 4 HIS A  72
PHE A  45
LEU A 358
PRO A 377
 None
 1.35A 4o8zA-5yy0A:
undetectable		 4o8zA-5yy0A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a70 -

(-) 		no annotation 4 PHE B3977
PHE B3888
LEU B3956
PRO B3900
 None
 1.38A 4o8zA-6a70B:
undetectable		 4o8zA-6a70B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byn WD REPEAT-CONTAINING
PROTEIN 5

(Homo sapiens) 		no annotation 4 PHE W 263
PHE W 219
LEU W 234
PRO W 216
 None
 1.45A 4o8zA-6bynW:
undetectable		 4o8zA-6bynW:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)

(Escherichia
coli) 		no annotation 4 PHE A 521
HIS A 382
LEU A 480
PRO A 369
 None
 1.30A 4o8zA-6d5iA:
undetectable		 4o8zA-6d5iA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd6 PHOTOLYASE PHRB

(Agrobacterium
tumefaciens) 		no annotation 4 PHE A 330
PHE A 413
LEU A 464
PRO A 480
 None
 1.15A 4o8zA-6dd6A:
2.3		 4o8zA-6dd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egt GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		no annotation 4 PHE A 905
PHE A 850
LEU A 929
PRO A 972
 None
 1.34A 4o8zA-6egtA:
undetectable		 4o8zA-6egtA:
20.41