SIMILAR PATTERNS OF AMINO ACIDS FOR 4O8J_A_ADNA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		5 LEU A 658
GLN A 699
PRO A 661
ASP A 535
HIS A 223
 None
None
None
None
PLP  A 955 (-3.4A)
 1.49A 4o8jA-1c4kA:
0.9		 4o8jA-1c4kA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1

(Homo sapiens) 		PF00415
(RCC1) 		5 GLN B 123
LEU B  82
GLN B  71
PRO B  34
HIS B  30
 None
 1.23A 4o8jA-1i2mB:
0.0		 4o8jA-1i2mB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		5 LEU A 680
GLN A 635
PHE A 586
ASP A 732
HIS A 735
 None
 1.13A 4o8jA-1lnsA:
0.0		 4o8jA-1lnsA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 GLN A 570
LEU A 552
PRO A 576
TYR A 505
ASP A 545
 None
 1.46A 4o8jA-1qf7A:
0.0		 4o8jA-1qf7A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		6 ARG A 365
LEU A 286
GLN A 368
PRO A 256
PRO A 257
PHE A 253
 None
 1.44A 4o8jA-2gduA:
0.0		 4o8jA-2gduA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2s MUSCLEBLIND-LIKE
PROTEIN 1

(Homo sapiens) 		PF00642
(zf-CCCH) 		5 LEU A 182
PRO A 239
TYR A 224
GLN A 244
HIS A 242
 None
 1.25A 4o8jA-3d2sA:
0.0		 4o8jA-3d2sA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzy RTX TOXIN RTXA

(Vibrio cholerae) 		PF11713
(Peptidase_C80) 		5 GLN A3461
ARG A3513
GLN A3515
ASP A3606
HIS A3483
 None
IHP  A8000 (-2.6A)
IHP  A8000 ( 4.4A)
None
IHP  A8000 (-3.8A)
 1.19A 4o8jA-3fzyA:
0.0		 4o8jA-3fzyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cq6 ALLENE OXIDE CYCLASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF06351
(Allene_ox_cyc) 		5 LEU A 134
PRO A 164
PRO A 163
ASP A 110
GLN A 132
 None
 1.29A 4o8jA-4cq6A:
0.0		 4o8jA-4cq6A:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o89 RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Pyrococcus
horikoshii) 		PF01137
(RTC)
PF05189
(RTC_insert) 		11 GLN A  14
ARG A  17
LEU A  97
PRO A 127
PRO A 128
TYR A 131
ASP A 250
PHE A 283
ASP A 286
GLN A 287
HIS A 307
 None
CIT  A 401 (-3.0A)
None
None
None
None
None
None
None
None
None
 0.96A 4o8jA-4o89A:
56.9		 4o8jA-4o89A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o89 RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Pyrococcus
horikoshii) 		PF01137
(RTC)
PF05189
(RTC_insert) 		6 LEU A  97
GLN A 100
PRO A 127
ASP A 286
GLN A 287
HIS A 307
 None
 1.18A 4o8jA-4o89A:
56.9		 4o8jA-4o89A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3

(Pseudomonas
aeruginosa) 		PF01471
(PG_binding_1)
PF13406
(SLT_2) 		5 GLN A 365
LEU A 369
PRO A 410
TYR A 409
ASP A 407
 None
 1.20A 4o8jA-5ao8A:
undetectable		 4o8jA-5ao8A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrr PSEUDOKINASE FAM20A

(Homo sapiens) 		PF06702
(Fam20C) 		5 ARG A 352
LEU A 344
PRO A 279
PRO A 280
ASP A 430
 None
 1.46A 4o8jA-5wrrA:
0.2		 4o8jA-5wrrA:
20.41