SIMILAR PATTERNS OF AMINO ACIDS FOR 4O8F_A_BRLA501_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)

(Escherichia
coli) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain) 		4 GLY B1579
LEU B1618
ILE B1610
LEU B1653
 None
 0.82A 4o8fA-1a9xB:
0.0		 4o8fA-1a9xB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT
[NIFE] HYDROGENASE
SMALL SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 GLY B 174
LEU B 124
ILE A  48
LEU B 206
LEU B 133
 None
 1.47A 4o8fA-1e3dB:
0.0		 4o8fA-1e3dB:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 GLY A 158
LEU A  86
ILE A 160
LEU A 438
 None
 0.84A 4o8fA-1ewkA:
0.0		 4o8fA-1ewkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gdh D-GLYCERATE
DEHYDROGENASE

(Hyphomicrobium
methylovorum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A 262
LEU A 162
LEU A 145
LEU A 229
 None
 0.83A 4o8fA-1gdhA:
0.0		 4o8fA-1gdhA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpz COMPLEMENT C1R
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 GLY A 472
LEU A 546
LEU A 556
LEU A 561
 None
 0.85A 4o8fA-1gpzA:
undetectable		 4o8fA-1gpzA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mwi G/U
MISMATCH-SPECIFIC
DNA GLYCOSYLASE

(Escherichia
coli) 		PF03167
(UDG) 		4 GLY A  65
LEU A 159
ILE A  41
LEU A 107
 None
 0.83A 4o8fA-1mwiA:
0.0		 4o8fA-1mwiA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1quq PROTEIN (REPLICATION
PROTEIN A 14 KD
SUBUNIT)

(Homo sapiens) 		PF08661
(Rep_fac-A_3) 		4 GLY B  71
LEU B  17
ILE B  53
LEU B 115
 None
 0.77A 4o8fA-1quqB:
undetectable		 4o8fA-1quqB:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		4 GLY A  87
LEU A 176
LEU A 108
LEU A  71
 SAH  A 301 (-3.4A)
None
None
None
 0.88A 4o8fA-1susA:
0.0		 4o8fA-1susA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY B  31
LEU B 191
ILE B  51
LEU B 333
 NA  B1091 (-3.8A)
None
None
None
 0.70A 4o8fA-1tqyB:
0.0		 4o8fA-1tqyB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Archaeoglobus
fulgidus) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 GLY A  83
LEU A 102
ILE A 108
LEU A 124
LEU A  65
 None
 1.35A 4o8fA-1txgA:
undetectable		 4o8fA-1txgA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqr HYPOTHETICAL PROTEIN
CJ0248

(Campylobacter
jejuni) 		PF08668
(HDOD) 		4 GLY A  82
ILE A  37
LEU A  26
LEU A  57
 None
 0.73A 4o8fA-1vqrA:
undetectable		 4o8fA-1vqrA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 GLY A 937
LEU A 978
LEU A 964
LEU A 861
 None
 0.77A 4o8fA-1xc6A:
undetectable		 4o8fA-1xc6A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmx HYPOTHETICAL PROTEIN
VC1899

(Vibrio cholerae) 		PF09002
(DUF1887) 		4 GLY A 249
LEU A 275
LEU A 168
LEU A 366
 None
None
FMT  A 406 (-4.2A)
None
 0.80A 4o8fA-1xmxA:
undetectable		 4o8fA-1xmxA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbr CONSERVED
HYPOTHETICAL PROTEIN

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		4 GLY A  89
LEU A 141
LEU A 137
LEU A 187
 None
 0.83A 4o8fA-1zbrA:
undetectable		 4o8fA-1zbrA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A 163
LEU A  93
ILE A  44
LEU A 130
 None
 0.82A 4o8fA-1zwsA:
undetectable		 4o8fA-1zwsA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE

(Bacillus
anthracis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 GLY A 169
LEU A 178
ILE A 264
LEU A 236
 None
 0.84A 4o8fA-2btuA:
undetectable		 4o8fA-2btuA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 273
LEU A 291
ILE A 281
LEU A 344
 None
 0.86A 4o8fA-2cx9A:
undetectable		 4o8fA-2cx9A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES

(Escherichia
coli) 		PF07995
(GSDH) 		4 GLY A 100
LEU A  65
LEU A 132
LEU A  23
 None
None
None
EDO  A3016 ( 4.0A)
 0.74A 4o8fA-2g8sA:
undetectable		 4o8fA-2g8sA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ht6 GTP-BINDING PROTEIN
GEM

(Homo sapiens) 		PF00071
(Ras) 		4 GLY A  87
LEU A 129
LEU A 231
LEU A 171
 GDP  A 545 (-3.3A)
None
None
None
 0.84A 4o8fA-2ht6A:
undetectable		 4o8fA-2ht6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwa GLUTAMINE
CYCLOTRANSFERASE

(Carica papaya) 		PF05096
(Glu_cyclase_2) 		4 GLY A 208
LEU A 176
LEU A 274
LEU A 212
 None
 0.72A 4o8fA-2iwaA:
undetectable		 4o8fA-2iwaA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 GLY A 338
LEU A 373
ILE A 358
LEU A 197
 None
 0.86A 4o8fA-2iyoA:
undetectable		 4o8fA-2iyoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		4 GLY B 241
ILE B 191
LEU B 203
LEU B 257
 None
 0.86A 4o8fA-2p1nB:
undetectable		 4o8fA-2p1nB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5
REGULATOR OF
G-PROTEIN SIGNALING
9

(Mus musculus) 		PF00400
(WD40)
PF00610
(DEP)
PF00615
(RGS)
PF00631
(G-gamma) 		4 GLY B 295
LEU B  48
ILE A 260
LEU B  38
 None
GOL  A 905 ( 3.4A)
None
None
 0.86A 4o8fA-2pbiB:
undetectable		 4o8fA-2pbiB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi2 REPLICATION PROTEIN
A 14 KDA SUBUNIT

(Homo sapiens) 		PF08661
(Rep_fac-A_3) 		4 GLY E  71
LEU E  17
ILE E  53
LEU E 115
 None
 0.79A 4o8fA-2pi2E:
undetectable		 4o8fA-2pi2E:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qru UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF07859
(Abhydrolase_3) 		4 GLY A 105
LEU A 134
LEU A  76
LEU A 205
 None
None
EDO  A 279 (-4.7A)
None
 0.87A 4o8fA-2qruA:
undetectable		 4o8fA-2qruA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy0 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLY B 472
LEU B 546
LEU B 556
LEU B 561
 None
None
None
GOL  B 801 (-4.3A)
 0.84A 4o8fA-2qy0B:
undetectable		 4o8fA-2qy0B:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ro1 TRANSCRIPTION
INTERMEDIARY FACTOR
1-BETA

(Homo sapiens) 		PF00628
(PHD) 		4 GLY A 766
ILE A 785
LEU A 723
LEU A 747
 None
 0.86A 4o8fA-2ro1A:
undetectable		 4o8fA-2ro1A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 GLY A 149
LEU A  98
ILE A  89
LEU A  31
LEU A 183
 None
 1.37A 4o8fA-2wtbA:
undetectable		 4o8fA-2wtbA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 GLY A 447
LEU A 413
ILE A 435
LEU A 331
 None
 0.87A 4o8fA-2wtbA:
undetectable		 4o8fA-2wtbA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xj9 MIPZ

(Caulobacter
vibrioides) 		PF09140
(MipZ) 		4 GLY A  10
LEU A 108
ILE A  21
LEU A 264
 None
 0.84A 4o8fA-2xj9A:
undetectable		 4o8fA-2xj9A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 GLY A 139
ILE A 227
LEU A 345
LEU A 113
 None
HEM  A1400 (-3.6A)
HEM  A1400 ( 4.7A)
None
 0.74A 4o8fA-2xkrA:
undetectable		 4o8fA-2xkrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 GLY A 337
LEU A 333
ILE A 409
LEU A 362
 None
 0.88A 4o8fA-2xswA:
undetectable		 4o8fA-2xswA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxg DIHYDRODIPICOLINATE
SYNTHASE

(Methanocaldococcus
jannaschii) 		PF00701
(DHDPS) 		4 GLY A  42
LEU A  23
ILE A  59
LEU A 264
 None
 0.88A 4o8fA-2yxgA:
undetectable		 4o8fA-2yxgA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE

(Mycoplasma
pneumoniae) 		PF00579
(tRNA-synt_1b) 		4 GLY A  18
ILE A 212
LEU A 256
LEU A  27
 WSA  A1350 (-3.5A)
None
None
None
 0.78A 4o8fA-2yy5A:
undetectable		 4o8fA-2yy5A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		4 GLY A 418
LEU A 368
ILE A  28
LEU A  47
 None
 0.76A 4o8fA-2z00A:
undetectable		 4o8fA-2z00A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 GLY A  70
LEU A 101
ILE A  48
LEU A  85
 None
 0.81A 4o8fA-2z63A:
undetectable		 4o8fA-2z63A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 GLY A  70
LEU A 101
ILE A  48
LEU A  85
 None
 0.86A 4o8fA-2z65A:
undetectable		 4o8fA-2z65A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgh GRANZYME M

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLY A  27
LEU A 194
LEU A  87
LEU A  92
 None
 0.81A 4o8fA-2zghA:
undetectable		 4o8fA-2zghA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0p TRNA-DIHYDROURIDINE
SYNTHASE

(Thermus
thermophilus) 		PF01207
(Dus) 		4 GLY A 225
ILE A 206
LEU A   6
LEU A  22
 FMN  A 351 (-3.5A)
None
None
None
 0.86A 4o8fA-3b0pA:
undetectable		 4o8fA-3b0pA:
21.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLY A 284
LEU A 330
ILE A 341
LEU A 353
LEU A 453
 MC5  A   1 ( 4.5A)
MC5  A   1 (-4.4A)
MC5  A   1 (-4.5A)
MC5  A   1 (-4.7A)
MC5  A   1 (-4.2A)
 0.51A 4o8fA-3b0qA:
38.8		 4o8fA-3b0qA:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 GLY A 284
LEU A 353
ILE A 341
LEU A 255
 MC5  A   1 ( 4.5A)
MC5  A   1 (-4.7A)
MC5  A   1 (-4.5A)
None
 0.84A 4o8fA-3b0qA:
38.8		 4o8fA-3b0qA:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 LEU A 747
ILE A 704
LEU A 759
LEU A 563
 None
 0.84A 4o8fA-3bg9A:
undetectable		 4o8fA-3bg9A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clk TRANSCRIPTION
REGULATOR

(Lactobacillus
plantarum) 		PF13377
(Peripla_BP_3) 		4 GLY A 185
LEU A 239
ILE A 216
LEU A 286
 None
 0.84A 4o8fA-3clkA:
undetectable		 4o8fA-3clkA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		4 GLY A  61
LEU A  27
LEU A 267
LEU A  39
 None
 0.85A 4o8fA-3czeA:
undetectable		 4o8fA-3czeA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkn PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Canis lupus) 		PF00344
(SecY) 		4 LEU A 404
ILE A 170
LEU A 261
LEU A 375
 None
 0.88A 4o8fA-3dknA:
undetectable		 4o8fA-3dknA:
22.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		4 GLY D 284
LEU D 330
ILE D 341
LEU D 353
 PLB  D 701 (-3.3A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
None
 0.29A 4o8fA-3dzuD:
35.9		 4o8fA-3dzuD:
94.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb7 INSECTICIDAL
DELTA-ENDOTOXIN
CRY8EA1

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 GLY A  78
LEU A 103
ILE A 281
LEU A 208
 None
 0.88A 4o8fA-3eb7A:
undetectable		 4o8fA-3eb7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE

(Bacillus
subtilis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 GLY A 118
ILE A 166
LEU A  68
LEU A  78
 None
 0.85A 4o8fA-3egoA:
undetectable		 4o8fA-3egoA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 LEU A 914
ILE A 718
LEU A 773
LEU A 867
 None
 0.87A 4o8fA-3eh1A:
undetectable		 4o8fA-3eh1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1s VITAMIN K-DEPENDENT
PROTEIN Z

(Homo sapiens) 		PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		4 GLY B 164
LEU B 327
LEU B 222
LEU B 227
 None
 0.87A 4o8fA-3f1sB:
undetectable		 4o8fA-3f1sB:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 GLY A  70
LEU A 101
ILE A  48
LEU A  85
 None
 0.84A 4o8fA-3fxiA:
undetectable		 4o8fA-3fxiA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtu GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 GLY B  15
LEU B  80
LEU B   8
LEU B 201
 None
 0.82A 4o8fA-3gtuB:
undetectable		 4o8fA-3gtuB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1n PROBABLE GLUTATHIONE
S-TRANSFERASE

(Bordetella
bronchiseptica) 		PF14497
(GST_C_3) 		4 GLY A  13
LEU A  72
LEU A   5
LEU A 211
 CL  A 234 (-3.6A)
None
None
None
 0.86A 4o8fA-3h1nA:
undetectable		 4o8fA-3h1nA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomyces
pombe) 		no annotation 4 GLY B 133
LEU B 164
ILE B 122
LEU B 293
 None
 0.78A 4o8fA-3h4jB:
undetectable		 4o8fA-3h4jB:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5c VITAMIN K-DEPENDENT
PROTEIN Z

(Homo sapiens) 		PF00008
(EGF)
PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		4 GLY B 164
LEU B 327
LEU B 222
LEU B 227
 None
 0.75A 4o8fA-3h5cB:
undetectable		 4o8fA-3h5cB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il7 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Staphylococcus
aureus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 GLY A 158
ILE A  17
LEU A 148
LEU A 190
 None
 0.84A 4o8fA-3il7A:
undetectable		 4o8fA-3il7A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 GLY A 417
ILE A 437
LEU A  87
LEU A 128
 None
 0.87A 4o8fA-3juxA:
undetectable		 4o8fA-3juxA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS

(Corynebacterium
glutamicum) 		PF00578
(AhpC-TSA) 		4 GLY A  69
LEU A 118
LEU A  10
LEU A 146
 None
 0.86A 4o8fA-3lorA:
undetectable		 4o8fA-3lorA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxa PROTEIN S100-A16

(Homo sapiens) 		PF01023
(S_100) 		4 GLY A  88
LEU A  50
LEU A  62
LEU A  15
 None
 0.88A 4o8fA-3nxaA:
undetectable		 4o8fA-3nxaA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odg XANTHOSINE
PHOSPHORYLASE

(Yersinia
pseudotuberculosis) 		PF01048
(PNP_UDP_1) 		4 LEU A 281
ILE A  51
LEU A  40
LEU A 237
 None
 0.88A 4o8fA-3odgA:
undetectable		 4o8fA-3odgA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 LEU A 324
ILE A 309
LEU A 279
LEU A 384
 None
 0.76A 4o8fA-3ov3A:
undetectable		 4o8fA-3ov3A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oxn PUTATIVE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Vibrio
parahaemolyticus) 		PF03466
(LysR_substrate) 		4 GLY A 165
LEU A 152
LEU A 180
LEU A 308
 None
 0.85A 4o8fA-3oxnA:
undetectable		 4o8fA-3oxnA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q87 N6 ADENINE SPECIFIC
DNA METHYLASE

(Encephalitozoon
cuniculi) 		PF05175
(MTS) 		4 GLY B 161
LEU B  13
LEU B  22
LEU B  71
 None
 0.85A 4o8fA-3q87B:
undetectable		 4o8fA-3q87B:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		4 GLY A 216
ILE A 224
LEU A 259
LEU A 293
 None
None
None
PHE  A 400 (-4.1A)
 0.79A 4o8fA-3td9A:
undetectable		 4o8fA-3td9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 GLY A  42
ILE A 270
LEU A 182
LEU A 147
 None
 0.87A 4o8fA-3vlaA:
undetectable		 4o8fA-3vlaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx4 PUTATIVE ABC
TRANSPORTER,
ATP-BINDING PROTEIN
COMA

(Streptococcus
mutans) 		PF00005
(ABC_tran) 		4 LEU A 695
ILE A 704
LEU A 688
LEU A 622
 None
 0.87A 4o8fA-3vx4A:
undetectable		 4o8fA-3vx4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE
REGULATORY PROTEIN

(Xenopus laevis) 		no annotation 4 GLY B 457
ILE B 484
LEU B 406
LEU B 415
 None
 0.84A 4o8fA-3w0lB:
undetectable		 4o8fA-3w0lB:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 GLY A 372
LEU A 384
LEU A 343
LEU A 324
 GLY  A 372 ( 0.0A)
LEU  A 384 ( 0.6A)
LEU  A 343 ( 0.6A)
LEU  A 324 ( 0.5A)
 0.88A 4o8fA-3wd7A:
undetectable		 4o8fA-3wd7A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		4 GLY A 142
ILE A 230
LEU A 348
LEU A 116
 None
HEM  A1402 (-4.4A)
HEM  A1402 ( 4.7A)
None
 0.79A 4o8fA-3zbyA:
undetectable		 4o8fA-3zbyA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 341
ILE A 432
LEU A 514
LEU A 528
 None
 0.87A 4o8fA-3zz1A:
undetectable		 4o8fA-3zz1A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b16 CHITINASE LIKE
LECTIN

(Tamarindus
indica) 		PF00704
(Glyco_hydro_18) 		4 GLY A  85
LEU A 105
ILE A 127
LEU A 136
 None
 0.88A 4o8fA-4b16A:
undetectable		 4o8fA-4b16A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 GLY A 974
ILE A 962
LEU A 954
LEU A1032
 None
 0.78A 4o8fA-4bfrA:
undetectable		 4o8fA-4bfrA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7w SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		4 GLY A 148
LEU A 164
ILE A 110
LEU A 197
 None
 0.83A 4o8fA-4d7wA:
undetectable		 4o8fA-4d7wA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9r COMPLEMENT FACTOR D

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLY A  43
LEU A 209
LEU A 103
LEU A 108
 None
 0.87A 4o8fA-4d9rA:
undetectable		 4o8fA-4d9rA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		4 GLY A 108
LEU A  73
ILE A 103
LEU A 151
 None
 0.71A 4o8fA-4e4yA:
undetectable		 4o8fA-4e4yA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecd CHORISMATE SYNTHASE

(Bifidobacterium
longum) 		PF01264
(Chorismate_synt) 		4 GLY A 306
LEU A 248
ILE A 234
LEU A 180
 None
 0.88A 4o8fA-4ecdA:
undetectable		 4o8fA-4ecdA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4f THREONINE SYNTHASE

(Brucella
melitensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 LEU A 127
ILE A 136
LEU A 119
LEU A  13
 None
 0.83A 4o8fA-4f4fA:
undetectable		 4o8fA-4f4fA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomyces
pombe) 		no annotation 4 GLY B 159
ILE B 172
LEU B  61
LEU B 234
 None
 0.85A 4o8fA-4fcxB:
undetectable		 4o8fA-4fcxB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		4 GLY A  89
LEU A  37
LEU A 143
LEU A 128
 None
 0.81A 4o8fA-4fdjA:
undetectable		 4o8fA-4fdjA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE

(Thermothelomyces
thermophila) 		no annotation 4 GLY A 238
ILE A 264
LEU A 178
LEU A 301
 None
 0.77A 4o8fA-4g4iA:
undetectable		 4o8fA-4g4iA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		4 GLY M 580
LEU M 559
LEU M 656
LEU M 642
 None
 0.83A 4o8fA-4gq2M:
undetectable		 4o8fA-4gq2M:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxr MALONYL COA
SYNTHETASE,
BENZOATE-COA LIGASE
CHIMERIC PROTEIN

(Paraburkholderia
xenovorans;
Rhodopseudomonas
palustris) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLY A  78
ILE A 103
LEU A  69
LEU A 180
 None
MLY  A 102 ( 3.9A)
None
None
 0.85A 4o8fA-4gxrA:
undetectable		 4o8fA-4gxrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 GLY A 118
LEU A 127
LEU A 109
LEU A 182
 None
 0.85A 4o8fA-4j0mA:
undetectable		 4o8fA-4j0mA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1l TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27) 		4 GLY A 161
LEU A 157
ILE A  45
LEU A 231
 None
 0.83A 4o8fA-4j1lA:
undetectable		 4o8fA-4j1lA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyj ENOYL-COA
HYDRATASE/ISOMERASE

(Novosphingobium
aromaticivorans) 		PF00378
(ECH_1) 		4 GLY A  57
LEU A  34
ILE A  19
LEU A 116
 None
 0.87A 4o8fA-4jyjA:
undetectable		 4o8fA-4jyjA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5u VARIABLE LYMPHOCYTE
RECEPTOR

(Petromyzon
marinus) 		no annotation 4 GLY B 108
LEU B  97
LEU B  80
LEU B 149
 GAL  B 301 ( 4.1A)
None
None
None
 0.81A 4o8fA-4k5uB:
undetectable		 4o8fA-4k5uB:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		4 GLY A1221
LEU A1059
ILE A1159
LEU A1177
 None
 0.87A 4o8fA-4kegA:
undetectable		 4o8fA-4kegA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 4 GLY H 331
LEU H 372
LEU H 301
LEU H 148
 None
 0.83A 4o8fA-4l0oH:
undetectable		 4o8fA-4l0oH:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhs UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14606
(Lipase_GDSL_3)
PF14607
(GxDLY) 		4 GLY A 217
ILE A 214
LEU A  75
LEU A 101
 None
 0.88A 4o8fA-4lhsA:
undetectable		 4o8fA-4lhsA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf9 HEMIN DEGRADING
FACTOR

(Pseudomonas
aeruginosa) 		PF05171
(HemS) 		4 GLY A  68
LEU A 113
ILE A 109
LEU A 167
 None
 0.88A 4o8fA-4mf9A:
undetectable		 4o8fA-4mf9A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 529
ILE A 499
LEU A 510
LEU A 582
 None
 0.82A 4o8fA-4mnaA:
undetectable		 4o8fA-4mnaA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx8 PERIPLASMIC BINDING
PROTEIN

(Xylanimonas
cellulosilytica) 		PF01497
(Peripla_BP_2) 		4 GLY A 147
LEU A 129
ILE A  58
LEU A 106
 None
 0.85A 4o8fA-4mx8A:
undetectable		 4o8fA-4mx8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME

(Escherichia
virus T4;
Saccharomyces
cerevisiae) 		PF00959
(Phage_lysozyme)
PF11951
(Fungal_trans_2) 		4 GLY A 816
LEU A 703
LEU A 763
LEU A 855
 None
 0.86A 4o8fA-4n9nA:
undetectable		 4o8fA-4n9nA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 GLY A 475
LEU A 496
ILE A 502
LEU A 463
 None
 0.87A 4o8fA-4om9A:
undetectable		 4o8fA-4om9A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pph CONGLUTIN GAMMA

(Lupinus
angustifolius) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 LEU A 177
ILE A 201
LEU A 164
LEU A  38
 None
 0.86A 4o8fA-4pphA:
undetectable		 4o8fA-4pphA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA

(Schizosaccharomyces
pombe) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		4 GLY A 125
LEU A 159
LEU A 238
LEU A  34
 None
None
GPL  A  67 ( 4.7A)
None
 0.86A 4o8fA-4pz7A:
undetectable		 4o8fA-4pz7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhr ALANINE RACEMASE

(Acinetobacter
baumannii) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 GLY A 119
ILE A  91
LEU A 108
LEU A 188
 None
 0.83A 4o8fA-4qhrA:
undetectable		 4o8fA-4qhrA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq1 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 GLY A 147
ILE A 102
LEU A 201
LEU A  70
 None
 0.80A 4o8fA-4qq1A:
undetectable		 4o8fA-4qq1A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u08 LIC11098

(Leptospira
interrogans) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 GLY A  66
LEU A  74
ILE A  41
LEU A  79
 None
 0.79A 4o8fA-4u08A:
undetectable		 4o8fA-4u08A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzj NOTUM

(Drosophila
melanogaster) 		PF03283
(PAE) 		4 GLY A 235
LEU A 231
LEU A 211
LEU A  88
 None
 0.85A 4o8fA-4uzjA:
undetectable		 4o8fA-4uzjA:
20.78