SIMILAR PATTERNS OF AMINO ACIDS FOR 4O7G_B_ASCB304_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 PHE A 117
HIS A 118
PHE A 261
ASN A  93
 None
C2O  A 500 ( 3.3A)
C2O  A 500 (-3.6A)
None
 1.34A 4o7gB-1bt2A:
0.5		 4o7gB-1bt2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 PHE A 261
HIS A 244
ILE A 241
PHE A 114
 C2O  A 500 (-3.6A)
C2O  A 500 ( 3.2A)
None
None
 1.13A 4o7gB-1bt2A:
0.5		 4o7gB-1bt2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		4 PHE A 198
HIS A 170
TYR A 297
ASN A  93
 TSN  A 502 ( 3.9A)
ZN  A 501 ( 3.1A)
TSN  A 502 (-4.3A)
None
 1.31A 4o7gB-1c3rA:
undetectable		 4o7gB-1c3rA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef5 RGL

(Mus musculus) 		PF00788
(RA) 		4 PHE A 728
ILE A 652
PHE A 717
ASN A 715
 None
 1.16A 4o7gB-1ef5A:
undetectable		 4o7gB-1ef5A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7y TRANSLATIONALLY
CONTROLLED TUMOR
PROTEIN

(Schizosaccharomyces
pombe) 		PF00838
(TCTP) 		4 PHE A 117
ILE A 121
TYR A  84
PHE A 159
 None
 1.47A 4o7gB-1h7yA:
0.1		 4o7gB-1h7yA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbz CATALASE

(Micrococcus
luteus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 PHE A  68
ILE A 314
PHE A 319
ASN A 361
 None
None
HEM  A 504 (-4.6A)
None
 1.23A 4o7gB-1hbzA:
undetectable		 4o7gB-1hbzA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k77 HYPOTHETICAL PROTEIN
YGBM

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		4 HIS A 103
TYR A 153
PHE A 122
ASN A 125
 None
 1.37A 4o7gB-1k77A:
undetectable		 4o7gB-1k77A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2m REP PROTEIN

(Tomato yellow
leaf curl
Sardinia virus) 		PF00799
(Gemini_AL1) 		4 PHE A   7
ILE A   9
TYR A  68
PHE A  76
 None
 1.31A 4o7gB-1l2mA:
undetectable		 4o7gB-1l2mA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9x GAMMA-GLUTAMYL
HYDROLASE

(Homo sapiens) 		PF07722
(Peptidase_C26) 		4 PHE A 251
ILE A  12
PHE A 104
ASN A 258
 None
 1.25A 4o7gB-1l9xA:
undetectable		 4o7gB-1l9xA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE

(Pseudomonas sp.
WBC-3) 		PF00753
(Lactamase_B) 		4 PHE A 213
ILE A 145
TYR A 241
PHE A 216
 None
 1.48A 4o7gB-1p9eA:
0.0		 4o7gB-1p9eA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		4 PHE A 368
ILE A 366
PHE A 351
ASN A 677
 None
 1.39A 4o7gB-1pemA:
1.2		 4o7gB-1pemA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u69 HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF06983
(3-dmu-9_3-mt) 		4 PHE A  76
HIS A  72
ILE A 114
TYR A  11
 None
 1.04A 4o7gB-1u69A:
undetectable		 4o7gB-1u69A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE

(Bacillus
subtilis) 		PF03102
(NeuB)
PF08666
(SAF) 		4 PHE A 340
ILE A 306
PHE A 318
ASN A 322
 None
 1.33A 4o7gB-1vliA:
undetectable		 4o7gB-1vliA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		4 PHE A 265
ILE A 266
TYR A 291
PHE A 251
 None
 1.11A 4o7gB-1wraA:
undetectable		 4o7gB-1wraA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA

(Bacillus
subtilis) 		PF00496
(SBP_bac_5) 		4 PHE A 105
TYR A  53
PHE A 177
ASN A 175
 None
 1.28A 4o7gB-1xocA:
undetectable		 4o7gB-1xocA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3d 2-OXOPROPYL-COM
REDUCTASE

(Xanthobacter
autotrophicus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PHE A 233
ILE A 122
TYR A 211
PHE A 200
 None
 1.18A 4o7gB-2c3dA:
undetectable		 4o7gB-2c3dA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		4 PHE A  73
ILE A 277
PHE A  53
ASN A  55
 None
 1.42A 4o7gB-2eaeA:
1.6		 4o7gB-2eaeA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 PHE A 628
TYR A 310
PHE A 445
ASN A 441
 None
 1.43A 4o7gB-2fuqA:
2.3		 4o7gB-2fuqA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL

(Escherichia
coli) 		PF03466
(LysR_substrate) 		4 PHE A 265
HIS A 168
ILE A 207
TYR A 197
 None
 1.50A 4o7gB-2fyiA:
undetectable		 4o7gB-2fyiA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hng HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF06619
(DUF1149) 		4 PHE A  65
ILE A  70
PHE A 128
ASN A 108
 None
 1.48A 4o7gB-2hngA:
undetectable		 4o7gB-2hngA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8v THIOREDOXIN
DOMAIN-CONTAINING
PROTEIN 12

(Homo sapiens) 		PF13899
(Thioredoxin_7) 		4 HIS A  24
ILE A  45
TYR A 126
PHE A 102
 None
 1.30A 4o7gB-2k8vA:
undetectable		 4o7gB-2k8vA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2le1 UNCHARACTERIZED
PROTEIN

(Thermobifida
fusca) 		PF10604
(Polyketide_cyc2) 		4 PHE A 111
HIS A  89
TYR A  77
PHE A 130
 None
 1.15A 4o7gB-2le1A:
undetectable		 4o7gB-2le1A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p31 GLUTATHIONE
PEROXIDASE 7

(Homo sapiens) 		PF00255
(GSHPx) 		4 PHE A 129
HIS A 126
ILE A 118
PHE A 115
 None
 1.27A 4o7gB-2p31A:
undetectable		 4o7gB-2p31A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 230
TYR A 207
PHE A 320
ASN A 321
 None
 1.46A 4o7gB-2w4oA:
undetectable		 4o7gB-2w4oA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3

(Mus musculus) 		PF06470
(SMC_hinge) 		4 PHE B 586
HIS B 560
PHE B 575
ASN B 576
 None
 1.37A 4o7gB-2wd5B:
undetectable		 4o7gB-2wd5B:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywg GTP-BINDING PROTEIN
LEPA

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		4 PHE A  86
HIS A 349
ILE A 352
TYR A 319
 None
 1.24A 4o7gB-2ywgA:
undetectable		 4o7gB-2ywgA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 PHE A 345
ILE A 439
PHE A 408
ASN A 390
 None
 1.16A 4o7gB-3cwgA:
3.9		 4o7gB-3cwgA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gec PERIOD CIRCADIAN
PROTEIN

(Drosophila
melanogaster) 		PF00989
(PAS)
PF14598
(PAS_11) 		4 PHE A 461
ILE A 463
TYR A 377
PHE A 391
 None
 1.05A 4o7gB-3gecA:
undetectable		 4o7gB-3gecA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana) 		PF13847
(Methyltransf_31) 		4 PHE A 809
ILE A 779
TYR A 924
PHE A 817
 None
SAH  A 951 (-3.9A)
None
None
 1.30A 4o7gB-3htxA:
undetectable		 4o7gB-3htxA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq3 LOMBRICINE KINASE

(Urechis caupo) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 PHE A  87
HIS A  84
ILE A  80
ASN A 261
 None
 0.97A 4o7gB-3jq3A:
undetectable		 4o7gB-3jq3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju5 ARGININE KINASE

(Apostichopus
japonicus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 PHE A  91
HIS A  88
ILE A  84
ASN A 265
 None
 0.82A 4o7gB-3ju5A:
undetectable		 4o7gB-3ju5A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpx APOPHOTOPROTEIN
CLYTIN-3

(Clytia gregaria) 		PF13202
(EF-hand_5) 		4 PHE A  91
HIS A  25
TYR A 183
PHE A  74
 CZH  A 201 (-4.2A)
CZH  A 201 (-3.8A)
None
None
 1.46A 4o7gB-3kpxA:
undetectable		 4o7gB-3kpxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ILE A 382
TYR A 405
PHE A 350
ASN A 395
 None
 1.46A 4o7gB-3m4pA:
undetectable		 4o7gB-3m4pA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msv NUCLEAR IMPORT
ADAPTOR, NRO1

(Schizosaccharomyces
pombe) 		PF12753
(Nro1) 		4 PHE A  93
HIS A  97
ILE A  96
ASN A 142
 None
 1.25A 4o7gB-3msvA:
4.0		 4o7gB-3msvA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		4 PHE A 379
HIS A 376
ILE A 380
TYR A 283
 None
 1.39A 4o7gB-3mx3A:
4.5		 4o7gB-3mx3A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q33 HISTONE
ACETYLTRANSFERASE
RTT109

(Saccharomyces
cerevisiae) 		PF08214
(HAT_KAT11) 		4 PHE A  53
HIS A  51
ILE A 111
TYR A 119
 None
 1.48A 4o7gB-3q33A:
undetectable		 4o7gB-3q33A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvn MANGANESE-CONTAINING
SUPEROXIDE DISMUTASE

(Candida
albicans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 ILE A  24
TYR A 187
PHE A  83
ASN A  86
 None
 1.39A 4o7gB-3qvnA:
undetectable		 4o7gB-3qvnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4r HYPOTHETICAL
FIMBRIAL ASSEMBLY
PROTEIN

(Parabacteroides
distasonis) 		PF06321
(P_gingi_FimA) 		4 PHE A 136
ILE A 154
TYR A 254
ASN A  68
 None
EDO  A 325 ( 4.4A)
None
None
 1.48A 4o7gB-3r4rA:
undetectable		 4o7gB-3r4rA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpc POSSIBLE
METAL-DEPENDENT
HYDROLASE

(Veillonella
parvula) 		PF12706
(Lactamase_B_2) 		4 HIS A 129
ILE A 200
PHE A  36
ASN A 228
 ZN  A 301 (-3.3A)
None
None
None
 1.48A 4o7gB-3rpcA:
undetectable		 4o7gB-3rpcA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtg HIGH CHORIOLYTIC
ENZYME 1

(Oryzias latipes) 		PF01400
(Astacin) 		4 HIS A 154
ILE A 179
TYR A 147
ASN A 123
 None
 1.24A 4o7gB-3vtgA:
undetectable		 4o7gB-3vtgA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 ILE A 331
TYR A 419
PHE A 344
ASN A 334
 None
 1.17A 4o7gB-3zx2A:
undetectable		 4o7gB-3zx2A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 PHE A 222
ILE A 220
PHE A 430
ASN A 429
 None
 1.29A 4o7gB-3zx2A:
undetectable		 4o7gB-3zx2A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apl APICAL MEMBRANE
ANTIGEN 1

(Neospora
caninum) 		PF02430
(AMA-1) 		4 PHE A 434
TYR A 288
PHE A  67
ASN A  65
 None
 1.49A 4o7gB-4aplA:
undetectable		 4o7gB-4aplA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4br6 SUPEROXIDE DISMUTASE

(Chaetomium
thermophilum) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 ILE A  18
TYR A 177
PHE A  77
ASN A  80
 None
 1.46A 4o7gB-4br6A:
undetectable		 4o7gB-4br6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PHE A  79
HIS A 134
ILE A  60
TYR A  44
 None
 1.43A 4o7gB-4ewtA:
undetectable		 4o7gB-4ewtA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 PHE A 174
ILE A 331
PHE A  41
ASN A 304
 None
 1.09A 4o7gB-4hjlA:
undetectable		 4o7gB-4hjlA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkh PUTATIVE TYPE VI
SECRETION PROTEIN

(Escherichia
coli) 		PF05638
(T6SS_HCP) 		4 PHE A  59
ILE A 142
PHE A 102
ASN A 103
 None
 1.38A 4o7gB-4hkhA:
undetectable		 4o7gB-4hkhA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		4 PHE A 221
ILE A 121
PHE A 260
ASN A 102
 PHE  A 221 ( 1.3A)
ILE  A 121 ( 0.7A)
PHE  A 260 ( 1.3A)
ASN  A 102 ( 0.6A)
 1.47A 4o7gB-4hneA:
undetectable		 4o7gB-4hneA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		4 PHE A 558
ILE A 542
PHE A 587
ASN A 588
 None
 1.27A 4o7gB-4mr0A:
undetectable		 4o7gB-4mr0A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		4 PHE A 123
HIS A 324
ILE A 351
ASN A 162
 None
 1.40A 4o7gB-4n0rA:
undetectable		 4o7gB-4n0rA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 218
ILE A 179
TYR A 275
PHE A 188
 None
 1.42A 4o7gB-4n5cA:
4.0		 4o7gB-4n5cA:
14.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o79 PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2

(Arabidopsis
thaliana) 		PF03188
(Cytochrom_B561) 		6 PHE A 105
HIS A 106
ILE A 111
TYR A 115
PHE A 182
ASN A 186
 None
HEM  A 301 (-3.8A)
None
HEM  A 301 ( 4.8A)
None
None
 0.43A 4o7gB-4o79A:
36.0		 4o7gB-4o79A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00496
(SBP_bac_5) 		4 ILE A 382
TYR A 241
PHE A 398
ASN A 412
 None
 1.32A 4o7gB-4oetA:
undetectable		 4o7gB-4oetA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p08 COCAINE ESTERASE

(Rhodococcus sp.
MB1) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 PHE A  84
ILE A 170
PHE A  78
ASN A  42
 None
 1.21A 4o7gB-4p08A:
undetectable		 4o7gB-4p08A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p08 COCAINE ESTERASE

(Rhodococcus sp.
MB1) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 PHE A 468
ILE A 474
TYR A 258
PHE A 299
 None
 1.46A 4o7gB-4p08A:
undetectable		 4o7gB-4p08A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbo C-REACTIVE PROTEIN

(Danio rerio) 		PF00354
(Pentaxin) 		4 PHE A  33
ILE A 128
PHE A  52
ASN A  63
 None
 1.21A 4o7gB-4pboA:
undetectable		 4o7gB-4pboA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdf 3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE

(Rhodococcus
rhodochrous) 		PF00355
(Rieske) 		4 PHE B 268
HIS B 260
ILE B 172
TYR B 233
 None
 1.49A 4o7gB-4qdfB:
undetectable		 4o7gB-4qdfB:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		4 PHE A1121
HIS A1124
ILE A1120
TYR A1093
 None
 1.48A 4o7gB-4rwfA:
undetectable		 4o7gB-4rwfA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux7 PUTATIVE PEPTIDASE
C60B, SORTASE B

(Clostridioides
difficile) 		PF04203
(Sortase) 		4 HIS A 238
ILE A 220
TYR A 198
ASN A 120
 None
 1.12A 4o7gB-4ux7A:
undetectable		 4o7gB-4ux7A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjf D-AMINO-ACID OXIDASE

(Sus scrofa) 		PF01266
(DAO) 		4 HIS B 217
ILE B 215
TYR B 224
ASN B 134
 None
None
98B  B 404 (-3.3A)
None
 1.49A 4o7gB-4yjfB:
undetectable		 4o7gB-4yjfB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		4 PHE A 124
HIS A 125
PHE A 273
ASN A  98
 None
CU  A 700 (-3.2A)
None
None
 1.27A 4o7gB-4z11A:
undetectable		 4o7gB-4z11A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zng PROLIDASE

(Lactococcus
lactis) 		no annotation 4 ILE C 330
TYR C 286
PHE C 245
ASN C 243
 None
 1.30A 4o7gB-4zngC:
undetectable		 4o7gB-4zngC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 PHE A1137
HIS A1138
TYR A1552
ASN A1248
 None
 1.49A 4o7gB-5a31A:
undetectable		 4o7gB-5a31A:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa1 PUTATIVE N-ACETYL
GLUCOSAMINYL
TRANSFERASE

(Raoultella
terrigena) 		PF05159
(Capsule_synth) 		4 HIS A  77
ILE A  33
TYR A  79
PHE A  22
 None
 1.34A 4o7gB-5fa1A:
undetectable		 4o7gB-5fa1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyj PUTATIVE PEPTIDASE
C60B, SORTASE B

(Clostridioides
difficile) 		PF04203
(Sortase) 		4 HIS A 221
ILE A 203
TYR A 181
ASN A 103
 None
 1.22A 4o7gB-5gyjA:
undetectable		 4o7gB-5gyjA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH

(synthetic
construct) 		PF00753
(Lactamase_B) 		4 PHE A 179
ILE A 112
TYR A 207
PHE A 182
 None
 1.47A 4o7gB-5hifA:
undetectable		 4o7gB-5hifA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		4 PHE A 463
HIS A 437
ILE A 460
TYR A 427
 None
 1.26A 4o7gB-5k04A:
1.1		 4o7gB-5k04A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 PHE B 106
HIS B 105
PHE B 228
ASN B 232
 None
 1.26A 4o7gB-5kohB:
undetectable		 4o7gB-5kohB:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n05 AUXILIARY ACTIVITY 9

(Lentinus
similis) 		PF03443
(Glyco_hydro_61) 		4 PHE A 102
HIS A 125
ILE A  82
ASN A 107
 None
 1.42A 4o7gB-5n05A:
undetectable		 4o7gB-5n05A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nop ATTACHMENT
GLYCOPROTEIN

(Mojiang
henipavirus) 		PF00423
(HN) 		4 PHE A 467
ILE A 448
TYR A 182
PHE A 515
 None
 1.23A 4o7gB-5nopA:
undetectable		 4o7gB-5nopA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2x UNCHARACTERIZED
PROTEIN LPG1670

(Legionella
pneumophila) 		no annotation 4 ILE A  98
TYR A 133
PHE A  81
ASN A  77
 None
 1.40A 4o7gB-5t2xA:
undetectable		 4o7gB-5t2xA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tir SUPEROXIDE DISMUTASE

(Trichoderma
reesei) 		no annotation 4 ILE A  22
TYR A 180
PHE A  81
ASN A  84
 None
 1.50A 4o7gB-5tirA:
undetectable		 4o7gB-5tirA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		4 PHE A 406
HIS A 398
ILE A 250
TYR A 369
 NAP  A 501 (-4.6A)
None
ZBZ  A 249 ( 4.0A)
None
 1.39A 4o7gB-5ucdA:
undetectable		 4o7gB-5ucdA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		4 HIS A  79
TYR A 302
PHE A  92
ASN A 258
 None
None
SAH  A 402 (-3.6A)
SAH  A 402 (-4.4A)
 1.31A 4o7gB-5vslA:
undetectable		 4o7gB-5vslA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x00 NUCLEOSIDE
DIPHOSPHATE KINASE

(Vibrio cholerae) 		no annotation 4 PHE A   7
HIS A 117
ILE A   9
TYR A  51
 None
 1.42A 4o7gB-5x00A:
undetectable		 4o7gB-5x00A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN

(SFTS
phlebovirus) 		PF07243
(Phlebovirus_G1) 		4 PHE C 135
ILE C 239
TYR C 318
ASN C 214
 None
 1.12A 4o7gB-5y10C:
undetectable		 4o7gB-5y10C:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		4 PHE A 492
HIS A 488
ILE A 489
PHE A 614
 None
 1.46A 4o7gB-5y7oA:
undetectable		 4o7gB-5y7oA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brm PUTATIVE
METAL-DEPENDENT
ISOTHIOCYANATE
HYDROLASE SAXA

(Pectobacterium
carotovorum) 		no annotation 4 HIS A 128
ILE A 198
PHE A  35
ASN A 226
 ZN  A 301 (-3.3A)
None
FMT  A 303 (-4.1A)
None
 1.34A 4o7gB-6brmA:
undetectable		 4o7gB-6brmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza B
virus) 		no annotation 4 PHE A 654
ILE A 686
PHE A 703
ASN A 704
 None
 1.04A 4o7gB-6f5oA:
undetectable		 4o7gB-6f5oA:
undetectable