SIMILAR PATTERNS OF AMINO ACIDS FOR 4O79_B_ASCB303

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lb3 FERRITIN LIGHT CHAIN
1

(Mus musculus) 		PF00210
(Ferritin) 		4 LYS A 140
TYR A 137
ARG A  68
ALA A  66
 None
 1.41A 4o79B-1lb3A:
4.7		 4o79B-1lb3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkb LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 LYS A  32
LYS A  35
TYR A  37
ALA A 537
 None
 1.26A 4o79B-1wkbA:
0.1		 4o79B-1wkbA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		4 LYS A 539
LYS A 543
ARG A  24
ALA A  25
 None
 1.45A 4o79B-2vlcA:
0.0		 4o79B-2vlcA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		4 TYR A 251
ARG A 290
ALA A 289
MET A 288
 None
 1.04A 4o79B-2zuyA:
undetectable		 4o79B-2zuyA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR

(Bordetella
pertussis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 LYS A 417
TYR A 414
ARG A 450
ALA A 449
 None
 1.25A 4o79B-3efmA:
undetectable		 4o79B-3efmA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1

(Danio rerio) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 LYS A 336
TYR A 317
ARG A 268
ALA A 264
 None
 1.33A 4o79B-3jafA:
5.4		 4o79B-3jafA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1

(Danio rerio) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 LYS A 336
TYR A 317
ARG A 268
ALA A 267
 None
 1.45A 4o79B-3jafA:
5.4		 4o79B-3jafA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5w L-ORNITHINE
5-MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF13434
(K_oxygenase) 		4 LYS A 206
TYR A 230
ALA A 198
MET A 197
 None
 1.21A 4o79B-3s5wA:
0.0		 4o79B-3s5wA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl6 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Entamoeba
histolytica) 		PF01048
(PNP_UDP_1) 		4 TYR A 124
ARG A 195
ALA A 194
MET A 191
 None
 1.34A 4o79B-3tl6A:
undetectable		 4o79B-3tl6A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN

(Bacillus
licheniformis) 		PF01839
(FG-GAP) 		4 TYR A 254
ARG A 293
ALA A 292
MET A 291
 None
 1.00A 4o79B-4cagA:
undetectable		 4o79B-4cagA:
18.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o79 PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2

(Arabidopsis
thaliana) 		PF03188
(Cytochrom_B561) 		4 LYS A  81
TYR A 140
ALA A 151
MET A 154
 SO4  A 303 (-2.6A)
HEM  A 302 (-4.3A)
None
HEM  A 302 (-3.8A)
 0.31A 4o79B-4o79A:
36.0		 4o79B-4o79A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o79 PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2

(Arabidopsis
thaliana) 		PF03188
(Cytochrom_B561) 		4 LYS A  81
TYR A 140
ARG A 150
MET A 154
 SO4  A 303 (-2.6A)
HEM  A 302 (-4.3A)
SO4  A 303 (-3.8A)
HEM  A 302 (-3.8A)
 1.26A 4o79B-4o79A:
36.0		 4o79B-4o79A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 LYS A 915
TYR A 913
ALA A 968
MET A 954
 None
 1.41A 4o79B-5fqdA:
0.0		 4o79B-5fqdA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0v PROTEIN
O-GLUCOSYLTRANSFERAS
E 1

(Homo sapiens) 		PF05686
(Glyco_transf_90) 		4 TYR A 372
ARG A  74
ALA A  78
MET A  77
 None
 1.29A 4o79B-5l0vA:
0.2		 4o79B-5l0vA:
20.49