SIMILAR PATTERNS OF AMINO ACIDS FOR 4O4D_A_ACTA406

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea) 		PF01070
(FMN_dh) 		4 ASP A 293
THR A 292
PHE A  42
SER A  43
 None
 1.30A 4o4dA-1al8A:
0.0		 4o4dA-1al8A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)

(Sulfolobus
solfataricus) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		4 ASP O 196
THR O 141
SER O 191
HIS O 192
 None
None
SO4  O 607 (-4.8A)
SO4  O 601 (-3.8A)
 1.19A 4o4dA-1b7gO:
0.0		 4o4dA-1b7gO:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dci DIENOYL-COA
ISOMERASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 ASP A 305
THR A 303
PHE A 324
SER A 325
 None
 1.33A 4o4dA-1dciA:
0.0		 4o4dA-1dciA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 THR A 558
PHE A 606
SER A 624
HIS A 605
 None
 1.45A 4o4dA-1ex0A:
0.0		 4o4dA-1ex0A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhf SEED COAT PEROXIDASE

(Glycine max) 		PF00141
(peroxidase) 		4 ASP A 221
THR A 224
ARG A 231
SER A 234
 CA  A 502 (-3.5A)
CA  A 502 (-3.5A)
None
None
 1.44A 4o4dA-1fhfA:
0.0		 4o4dA-1fhfA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ASP A 464
THR A 436
ARG A 387
PHE A 459
 None
 1.31A 4o4dA-1gpeA:
undetectable		 4o4dA-1gpeA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyn CHLOROPLASTIC
ASCORBATE PEROXIDASE

(Nicotiana
tabacum) 		PF00141
(peroxidase) 		4 ASP A 224
THR A 223
SER A 160
HIS A 163
 None
HEM  A 296 (-3.5A)
HEM  A 296 ( 3.7A)
HEM  A 296 (-3.4A)
 1.22A 4o4dA-1iynA:
0.0		 4o4dA-1iynA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmo HEPARIN COFACTOR II

(Homo sapiens) 		PF00079
(Serpin) 		4 ASP A 453
THR A 451
PHE A 294
HIS A 292
 None
 1.50A 4o4dA-1jmoA:
0.0		 4o4dA-1jmoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		4 TRP A 221
THR A 224
PHE A 218
SER A  30
 None
 1.33A 4o4dA-1k1xA:
0.0		 4o4dA-1k1xA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqg FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
IRON-SULFUR SUBUNIT

(Escherichia
coli) 		PF09163
(Form-deh_trans)
PF12800
(Fer4_4)
PF13247
(Fer4_11) 		4 ASP B  67
PHE B  82
SER B  83
HIS B 238
 None
 1.45A 4o4dA-1kqgB:
undetectable		 4o4dA-1kqgB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n91 ORF, HYPOTHETICAL
PROTEIN

(Escherichia
coli) 		PF02594
(DUF167) 		4 ASP A  28
THR A  43
PHE A  58
HIS A  54
 None
 1.44A 4o4dA-1n91A:
undetectable		 4o4dA-1n91A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1of3 BETA-MANNOSIDASE

(Thermotoga
maritima) 		PF09212
(CBM27) 		4 TRP A  60
ASP A 154
SER A  58
HIS A 155
 None
 1.44A 4o4dA-1of3A:
undetectable		 4o4dA-1of3A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		4 ASP A 150
THR A 149
SER A  95
HIS A  91
 None
 1.45A 4o4dA-1pemA:
undetectable		 4o4dA-1pemA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhh SONIC HEDGEHOG

(Mus musculus) 		PF01085
(HH_signal) 		4 ASP A  96
THR A 126
ARG A 124
PHE A  87
 None
SO4  A 401 (-3.7A)
SO4  A 401 (-2.7A)
None
 1.45A 4o4dA-1vhhA:
undetectable		 4o4dA-1vhhA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqb UBIQUILIN 3

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ASP A  39
THR A  38
SER A  18
HIS A  20
 None
 1.45A 4o4dA-1yqbA:
undetectable		 4o4dA-1yqbA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0l 33H1 FV FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		4 THR C  20
ARG C  18
PHE C  63
SER C  64
 None
 1.25A 4o4dA-2a0lC:
undetectable		 4o4dA-2a0lC:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ASP A 440
THR A 148
SER A 438
HIS A 155
 GOL  A 778 (-4.0A)
PGE  A 777 ( 4.4A)
None
GOL  A 778 (-4.3A)
 1.42A 4o4dA-2f3oA:
undetectable		 4o4dA-2f3oA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT

(Mycobacterium
tuberculosis) 		no annotation 4 ASP H 478
THR H 481
PHE H 445
SER H 443
 None
 1.48A 4o4dA-2fhgH:
undetectable		 4o4dA-2fhgH:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj8 INTERFERON-INDUCED
17 KDA PROTEIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 TRP A 130
ASP A 126
ARG A 160
PHE A 129
 None
 1.43A 4o4dA-2hj8A:
undetectable		 4o4dA-2hj8A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivd PROTOPORPHYRINOGEN
OXIDASE

(Myxococcus
xanthus) 		PF01593
(Amino_oxidase) 		4 THR A 157
ARG A 149
PHE A 147
SER A 143
 None
 0.97A 4o4dA-2ivdA:
undetectable		 4o4dA-2ivdA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgr YEGS

(Escherichia
coli) 		PF00781
(DAGK_cat) 		4 ASP A 178
ARG A 179
PHE A 143
HIS A 262
 None
 1.50A 4o4dA-2jgrA:
undetectable		 4o4dA-2jgrA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mcm MACROMOMYCIN

(Streptomyces
macromomyceticus) 		PF00960
(Neocarzinostat) 		4 ASP A  47
THR A  50
PHE A  72
HIS A  69
 None
MRD  A 115 (-4.3A)
None
None
 1.13A 4o4dA-2mcmA:
undetectable		 4o4dA-2mcmA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE

(Rhodobacter
sphaeroides) 		PF00221
(Lyase_aromatic) 		4 ASP A 197
THR A 125
SER A 194
HIS A 195
 None
 1.37A 4o4dA-2o78A:
undetectable		 4o4dA-2o78A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q14 PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01966
(HD) 		4 ARG A  55
PHE A 102
SER A 103
HIS A 104
 None
 1.46A 4o4dA-2q14A:
undetectable		 4o4dA-2q14A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgo PUTATIVE FE-S
BIOSYNTHESIS PROTEIN

(Lactobacillus
acidophilus) 		PF01521
(Fe-S_biosyn) 		4 ASP A 107
PHE A  50
SER A  51
HIS A  49
 None
 1.42A 4o4dA-2qgoA:
undetectable		 4o4dA-2qgoA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN

(Shigella
flexneri) 		PF00497
(SBP_bac_3) 		4 THR A  91
ARG A  24
PHE A  30
SER A  27
 GLU  A1280 (-4.4A)
GLU  A1280 (-3.0A)
None
GLU  A1280 ( 4.0A)
 1.39A 4o4dA-2vhaA:
undetectable		 4o4dA-2vhaA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9p PIMD PROTEIN

(Streptomyces
natalensis) 		PF00067
(p450) 		4 ASP A 244
THR A 146
PHE A 390
HIS A 142
 None
 1.44A 4o4dA-2x9pA:
undetectable		 4o4dA-2x9pA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 ASP A 162
THR A 165
ARG A  42
SER A  60
 None
 1.33A 4o4dA-2xsgA:
undetectable		 4o4dA-2xsgA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 4 THR A 610
ARG A 546
PHE A 606
SER A 477
 None
SO4  A3001 (-3.7A)
None
None
 1.49A 4o4dA-2yr5A:
undetectable		 4o4dA-2yr5A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aka PUTATIVE CALCIUM
BINDING PROTEIN

(Streptomyces
coelicolor) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 TRP A  61
ASP A  29
PHE A  30
SER A  31
 None
CA  A 171 (-2.2A)
None
None
 1.36A 4o4dA-3akaA:
undetectable		 4o4dA-3akaA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 TRP A 390
THR A 379
PHE A 392
SER A 398
 None
 1.49A 4o4dA-3ce6A:
undetectable		 4o4dA-3ce6A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7n FLAVODOXIN,
WRBA-LIKE PROTEIN

(Agrobacterium
fabrum) 		PF03358
(FMN_red) 		4 THR A  20
PHE A  73
SER A  70
HIS A  14
 None
 1.14A 4o4dA-3d7nA:
undetectable		 4o4dA-3d7nA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF01191
(RNA_pol_Rpb5_C)
PF03871
(RNA_pol_Rpb5_N) 		4 ASP A1379
THR A1382
ARG E 207
SER E 205
 None
 1.32A 4o4dA-3h0gA:
1.7		 4o4dA-3h0gA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 ASP A 471
ARG A 170
PHE A 472
SER A 473
 None
 1.37A 4o4dA-3hhsA:
undetectable		 4o4dA-3hhsA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 183
ARG A 198
SER A 232
HIS A 180
 SO4  A 338 (-2.8A)
SO4  A 338 (-3.5A)
SO4  A 336 ( 4.6A)
SO4  A 336 (-4.4A)
 1.25A 4o4dA-3hjaA:
undetectable		 4o4dA-3hjaA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 ASP A 530
THR A 555
SER A 562
HIS A 533
 None
 1.34A 4o4dA-3k30A:
undetectable		 4o4dA-3k30A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		4 TRP A 349
THR A 157
PHE A 350
SER A 343
 ACT  A 962 (-4.3A)
None
ACT  A 962 ( 4.7A)
None
 1.08A 4o4dA-3k8kA:
undetectable		 4o4dA-3k8kA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Coxiella
burnetii) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 THR A  93
ARG A  94
PHE A  88
HIS A  89
 None
 1.29A 4o4dA-3k96A:
undetectable		 4o4dA-3k96A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0d GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bartonella
henselae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 183
ARG A 198
SER A 232
HIS A 180
 None
 1.30A 4o4dA-3l0dA:
1.0		 4o4dA-3l0dA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		4 ASP B 671
ARG B 513
PHE B 674
HIS B 673
 None
 1.15A 4o4dA-3l91B:
undetectable		 4o4dA-3l91B:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		4 ASP A 494
THR A 441
SER A 497
HIS A 519
 PO4  A 844 (-3.2A)
None
None
NI  A 842 (-3.2A)
 1.36A 4o4dA-3la4A:
undetectable		 4o4dA-3la4A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldu PUTATIVE METHYLASE

(Clostridioides
difficile) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 ASP A 156
THR A 157
PHE A 143
SER A 154
 None
 1.44A 4o4dA-3lduA:
0.3		 4o4dA-3lduA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		4 ASP A 438
ARG A 427
SER A 431
HIS A 435
 None
 1.26A 4o4dA-3mx3A:
undetectable		 4o4dA-3mx3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n1q DESERT HEDGEHOG
PROTEIN

(Homo sapiens) 		no annotation 4 ASP B  96
THR B 126
ARG B 124
PHE B  87
 CA  B 192 (-2.6A)
None
None
None
 1.44A 4o4dA-3n1qB:
undetectable		 4o4dA-3n1qB:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 ARG A 972
PHE A 746
SER A 744
HIS A 693
 None
 1.43A 4o4dA-3nafA:
undetectable		 4o4dA-3nafA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		4 THR A 292
ARG A 325
PHE A 424
SER A 425
 None
 1.34A 4o4dA-3qanA:
undetectable		 4o4dA-3qanA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyn TUMOR PROTEIN 63

(Homo sapiens) 		PF00870
(P53) 		4 THR A 157
ARG A 313
PHE A 142
SER A 145
 None
 1.44A 4o4dA-3qynA:
undetectable		 4o4dA-3qynA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rha PUTRESCINE OXIDASE

(Paenarthrobacter
aurescens) 		PF01593
(Amino_oxidase) 		4 TRP A 153
PHE A 150
SER A 149
HIS A 151
 None
 1.11A 4o4dA-3rhaA:
undetectable		 4o4dA-3rhaA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyp CIP1

(Trichoderma
reesei) 		no annotation 4 ASP A 206
ARG A  70
PHE A 138
HIS A  36
 CA  A1220 (-2.2A)
PEG  A1225 (-4.1A)
PEG  A1227 ( 4.6A)
None
 1.39A 4o4dA-3zypA:
undetectable		 4o4dA-3zypA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arv PHYTASE

(Yersinia
kristensenii) 		PF00328
(His_Phos_2) 		4 ASP A  88
ARG A  92
PHE A 125
HIS A 126
 PO4  A1416 ( 4.6A)
PO4  A1416 ( 3.2A)
None
PO4  A1416 (-4.1A)
 1.18A 4o4dA-4arvA:
undetectable		 4o4dA-4arvA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bh6 APC/C ACTIVATOR
PROTEIN CDH1

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ASP A 536
THR A 538
PHE A 516
HIS A 514
 None
 1.39A 4o4dA-4bh6A:
undetectable		 4o4dA-4bh6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn2 KINESIN-LIKE PROTEIN
KIF15

(Homo sapiens) 		PF00225
(Kinesin) 		4 TRP A 205
THR A 102
ARG A 208
SER A 219
 None
MG  A 601 ( 3.5A)
MG  A 601 ( 4.8A)
None
 1.19A 4o4dA-4bn2A:
undetectable		 4o4dA-4bn2A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF14574
(DUF4445) 		4 THR I 373
ARG I 537
PHE I 567
SER I 568
 None
 1.22A 4o4dA-4c1nI:
undetectable		 4o4dA-4c1nI:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnm TROPHOBLAST
GLYCOPROTEIN

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 ASP A 240
ARG A 214
SER A 262
HIS A 264
 None
 1.11A 4o4dA-4cnmA:
undetectable		 4o4dA-4cnmA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz6 NUCLEOSIDE
DIPHOSPHATE KINASE

(Borreliella
burgdorferi) 		PF00334
(NDK) 		4 ASP A 113
THR A 109
PHE A 114
SER A 115
 None
 1.12A 4o4dA-4dz6A:
0.9		 4o4dA-4dz6A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Burkholderia
pseudomallei) 		PF00753
(Lactamase_B) 		4 ASP A  72
THR A  11
SER A 266
HIS A  73
 CA  A 301 ( 4.9A)
None
None
None
 1.30A 4o4dA-4efzA:
undetectable		 4o4dA-4efzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejs ELONGATOR COMPLEX
PROTEIN 5
ELONGATOR COMPLEX
PROTEIN 6

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF10483
(Elong_Iki1)
no annotation 		4 THR C 172
ARG C 176
PHE B  60
SER B  59
 None
 1.49A 4o4dA-4ejsC:
undetectable		 4o4dA-4ejsC:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0c PHOSPHOLIPASE/CARBOX
YLESTERASE

(Dyadobacter
fermentans) 		PF02230
(Abhydrolase_2) 		4 ASP A 159
THR A 155
ARG A 189
HIS A 191
 None
None
None
CIT  A 301 (-4.2A)
 1.42A 4o4dA-4h0cA:
undetectable		 4o4dA-4h0cA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvv PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF00018
(SH3_1) 		4 THR A 126
ARG A 128
PHE A 102
SER A 101
 None
SO4  A 201 ( 4.4A)
None
SO4  A 201 (-2.9A)
 1.45A 4o4dA-4hvvA:
undetectable		 4o4dA-4hvvA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu4 ARGINASE

(Leishmania
mexicana) 		PF00491
(Arginase) 		4 ASP A 137
THR A 246
ARG A 191
HIS A 139
 MN  A 401 (-2.6A)
None
None
MN  A 402 ( 3.4A)
 1.31A 4o4dA-4iu4A:
undetectable		 4o4dA-4iu4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqr HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF14717
(DUF4465) 		4 ASP A 116
THR A 124
PHE A  82
SER A  81
 EDO  A 315 ( 4.9A)
EDO  A 311 ( 4.8A)
None
EDO  A 314 ( 3.7A)
 1.46A 4o4dA-4jqrA:
undetectable		 4o4dA-4jqrA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE

(Rhizomucor
miehei) 		PF03639
(Glyco_hydro_81) 		4 ASP A  98
THR A  96
ARG A 631
PHE A 632
 TRS  A 802 (-3.7A)
None
None
TRS  A 802 ( 4.0A)
 1.33A 4o4dA-4k35A:
1.4		 4o4dA-4k35A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		4 ASP A 308
THR A 286
ARG A 283
HIS A 311
 None
 1.33A 4o4dA-4k70A:
undetectable		 4o4dA-4k70A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2

(Homo sapiens) 		PF00415
(RCC1) 		4 ASP A 743
THR A 744
PHE A 742
HIS A 741
 None
 1.48A 4o4dA-4l1mA:
undetectable		 4o4dA-4l1mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 4 THR A 352
ARG A 259
SER A 490
HIS A 494
 None
 1.35A 4o4dA-4lc9A:
undetectable		 4o4dA-4lc9A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 THR A 303
PHE A 294
SER A 297
HIS A 292
 None
 1.39A 4o4dA-4lq1A:
undetectable		 4o4dA-4lq1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvo SUBTILISIN-LIKE
SERINE PROTEASE

(Plasmodium
falciparum) 		PF00082
(Peptidase_S8) 		4 ASP A 376
THR A 430
SER A 598
HIS A 379
 None
 1.36A 4o4dA-4lvoA:
undetectable		 4o4dA-4lvoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o01 BACTERIOPHYTOCHROME

(Deinococcus
radiodurans) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 ASP A 300
THR A 303
ARG A 100
SER A 112
 None
 1.49A 4o4dA-4o01A:
undetectable		 4o4dA-4o01A:
16.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o4f INOSITOL
HEXAKISPHOSPHATE
KINASE

(Entamoeba
histolytica) 		PF03770
(IPK) 		7 TRP A 107
ASP A 108
THR A 111
ARG A 119
PHE A 206
SER A 207
HIS A 234
 None
None
None
IHP  A 403 (-3.1A)
None
MG  A 402 ( 4.5A)
None
 0.68A 4o4dA-4o4fA:
40.9		 4o4dA-4o4fA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF12157
(DUF3591)
PF04658
(TAFII55_N) 		4 THR A 819
ARG B 276
SER A 882
HIS A 879
 None
 1.43A 4o4dA-4oy2A:
undetectable		 4o4dA-4oy2A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7w L-PROLINE
CIS-4-HYDROXYLASE

(Mesorhizobium
japonicum) 		PF05118
(Asp_Arg_Hydrox)
PF05373
(Pro_3_hydrox_C) 		4 THR A 193
PHE A 138
SER A 130
HIS A 139
 None
 1.47A 4o4dA-4p7wA:
undetectable		 4o4dA-4p7wA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pws PROLINE-RICH 28 KDA
ANTIGEN

(Mycobacterium
tuberculosis) 		PF10738
(Lpp-LpqN) 		4 ASP A 207
ARG A 230
PHE A 209
SER A 211
 None
 1.39A 4o4dA-4pwsA:
undetectable		 4o4dA-4pwsA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tjv VACUOLAR-SORTING
RECEPTOR 1

(Arabidopsis
thaliana) 		PF02225
(PA) 		4 ASP A 129
THR A 130
ARG A  95
PHE A  21
 None
 1.49A 4o4dA-4tjvA:
undetectable		 4o4dA-4tjvA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whm UDP-GLUCOSE:ANTHOCYA
NIDIN
3-O-GLUCOSYLTRANSFER
ASE

(Clitoria
ternatea) 		PF00201
(UDPGT) 		4 THR A 109
PHE A  37
SER A  36
HIS A   6
 None
None
ACT  A1004 (-2.8A)
None
 1.50A 4o4dA-4whmA:
undetectable		 4o4dA-4whmA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNG
ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNI

(Escherichia
coli;
Escherichia
coli) 		PF06754
(PhnG)
PF05861
(PhnI) 		4 THR A  56
PHE C 156
SER C 157
HIS C 154
 None
 1.20A 4o4dA-4xb6A:
undetectable		 4o4dA-4xb6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida) 		PF00753
(Lactamase_B) 		4 ASP A  78
THR A  17
SER A 266
HIS A  79
 GSH  A 302 ( 4.4A)
None
None
None
 1.30A 4o4dA-4yslA:
undetectable		 4o4dA-4yslA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zvi DNA GYRASE SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 ARG A 204
PHE A 216
SER A 202
HIS A 217
 None
 1.08A 4o4dA-4zviA:
undetectable		 4o4dA-4zviA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brq GLYCOSIDE HYDROLASE
FAMILY 13

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ASP A 168
PHE A 148
SER A 146
HIS A 165
 None
 1.45A 4o4dA-5brqA:
undetectable		 4o4dA-5brqA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8s GUANINE-N7
METHYLTRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		4 THR B 173
ARG B  84
PHE B 111
SER B 112
 None
 1.14A 4o4dA-5c8sB:
undetectable		 4o4dA-5c8sB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 ASP A 274
THR A 275
PHE A 186
HIS A 188
 None
 1.46A 4o4dA-5clwA:
undetectable		 4o4dA-5clwA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d88 PREDICTED PROTEASE
OF THE COLLAGENASE
FAMILY

(Methanopyrus
kandleri) 		PF01136
(Peptidase_U32) 		4 ASP A  15
THR A  16
SER A  10
HIS A  12
 None
 1.41A 4o4dA-5d88A:
undetectable		 4o4dA-5d88A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0q NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96

(Xenopus
tropicalis) 		PF04096
(Nucleoporin2) 		4 ASP B 810
THR B 808
ARG B 853
SER B 856
 None
 1.48A 4o4dA-5e0qB:
undetectable		 4o4dA-5e0qB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7l CONTACTIN-2

(Mus musculus) 		PF00041
(fn3) 		4 THR A 784
ARG A 754
SER A 779
HIS A 781
 None
 1.44A 4o4dA-5e7lA:
undetectable		 4o4dA-5e7lA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcr COMPLEMENT FACTOR D

(Mus musculus) 		PF00089
(Trypsin) 		4 ASP A 102
THR A 214
SER A  98
HIS A  57
 None
 1.36A 4o4dA-5fcrA:
undetectable		 4o4dA-5fcrA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcd CHITIN
ELICITOR-BINDING
PROTEIN

(Oryza sativa) 		PF01476
(LysM) 		4 ASP A 218
PHE A  31
SER A 163
HIS A 174
 None
 1.07A 4o4dA-5jcdA:
undetectable		 4o4dA-5jcdA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		4 ASP A  13
THR A 516
PHE A 329
SER A 332
 None
 1.01A 4o4dA-5mtzA:
undetectable		 4o4dA-5mtzA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ASP A 492
THR A 491
SER A 534
HIS A 531
 None
 1.47A 4o4dA-5nd5A:
undetectable		 4o4dA-5nd5A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0l RETICULON-4 RECEPTOR

(Mus musculus) 		no annotation 4 ASP A 111
ARG A 139
SER A  90
HIS A  89
 None
 1.41A 4o4dA-5o0lA:
undetectable		 4o4dA-5o0lA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
C-C MOTIF CHEMOKINE
5

(Clostridium
pasteurianum;
Homo sapiens;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin)
PF00048
(IL8) 		4 THR A 167
PHE A 182
SER B  31
HIS A 181
 None
 1.35A 4o4dA-5uiwA:
undetectable		 4o4dA-5uiwA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 ASP A 376
ARG A 277
SER A 281
HIS A  99
 UDP  A 501 ( 4.5A)
UDP  A 501 ( 3.9A)
None
None
 1.46A 4o4dA-5v0tA:
undetectable		 4o4dA-5v0tA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v23 TYPE IV PILIN
PROTEIN

(Neisseria
meningitidis) 		no annotation 4 ASP A 105
PHE A  83
SER A  79
HIS A  82
 None
 1.26A 4o4dA-5v23A:
undetectable		 4o4dA-5v23A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ASP B 379
THR B 381
PHE B 338
HIS B 336
 None
 1.33A 4o4dA-5vljB:
undetectable		 4o4dA-5vljB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4k DMSP LYASE DDDY

(Acinetobacter
bereziniae) 		no annotation 4 TRP A 318
PHE A 319
SER A 320
HIS A 285
 None
 1.07A 4o4dA-5y4kA:
undetectable		 4o4dA-5y4kA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 4 TRP A 243
THR A 246
SER A 417
HIS A 191
 None
 1.25A 4o4dA-5yl7A:
undetectable		 4o4dA-5yl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zic -

(-) 		no annotation 4 ASP A 696
PHE A 695
SER A 694
HIS A 720
 None
 0.97A 4o4dA-5zicA:
undetectable		 4o4dA-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 2

(Mus musculus) 		no annotation 4 THR D 125
ARG D 123
PHE D  62
SER D  63
 None
 0.91A 4o4dA-6cg0D:
undetectable		 4o4dA-6cg0D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33

(Homo sapiens) 		no annotation 4 ASP B 214
THR B 213
PHE B 210
HIS B 171
 None
 1.22A 4o4dA-6f9nB:
undetectable		 4o4dA-6f9nB:
undetectable