SIMILAR PATTERNS OF AMINO ACIDS FOR 4O2B_D_LOCD503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aog TRYPANOTHIONE
REDUCTASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 SER A 475
ALA A 390
VAL A 389
 None
 0.64A 4o2bC-1aogA:
2.1		 4o2bC-1aogA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at0 17-HEDGEHOG

(Drosophila
melanogaster) 		PF01079
(Hint) 		3 SER A 399
ALA A 397
VAL A 396
 None
 0.52A 4o2bC-1at0A:
undetectable		 4o2bC-1at0A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b89 PROTEIN (CLATHRIN
HEAVY CHAIN)

(Bos taurus) 		PF00637
(Clathrin) 		3 SER A1229
ALA A1240
VAL A1241
 None
 0.68A 4o2bC-1b89A:
undetectable		 4o2bC-1b89A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		3 SER M  36
ALA M  34
VAL M  33
 GOL  M 936 ( 4.5A)
None
None
 0.63A 4o2bC-1dwaM:
1.5		 4o2bC-1dwaM:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1etz FAB NC10.14 - HEAVY
CHAIN

(Mus musculus) 		no annotation 3 SER H 216
ALA H 211
VAL H 210
 None
 0.62A 4o2bC-1etzH:
undetectable		 4o2bC-1etzH:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3

(Rattus
norvegicus) 		PF06325
(PrmA) 		3 SER A 368
ALA A 366
VAL A 365
 None
 0.54A 4o2bC-1f3lA:
undetectable		 4o2bC-1f3lA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f89 32.5 KDA PROTEIN
YLR351C

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		3 SER A 238
ALA A 249
VAL A 248
 None
 0.62A 4o2bC-1f89A:
undetectable		 4o2bC-1f89A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.61A 4o2bC-1fptH:
undetectable		 4o2bC-1fptH:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hq8 NKG2-D

(Mus musculus) 		PF00059
(Lectin_C) 		3 SER A 204
ALA A 206
VAL A 207
 None
 0.68A 4o2bC-1hq8A:
undetectable		 4o2bC-1hq8A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli) 		PF00923
(TAL_FSA) 		3 SER A  94
ALA A  96
VAL A  97
 None
 0.62A 4o2bC-1i2oA:
undetectable		 4o2bC-1i2oA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		3 SER A 329
ALA A 388
VAL A 387
 None
 0.64A 4o2bC-1i5pA:
undetectable		 4o2bC-1i5pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibg IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.58A 4o2bC-1ibgH:
undetectable		 4o2bC-1ibgH:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibx CHIMERA OF IGG
BINDING PROTEIN G
AND DNA
FRAGMENTATION FACTOR
45

(Homo sapiens;
Streptococcus
sp.) 		PF02017
(CIDE-N) 		3 SER B  37
ALA B  35
VAL B  34
 None
 0.64A 4o2bC-1ibxB:
undetectable		 4o2bC-1ibxB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igj IGG2A-KAPPA 26-10
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 216
ALA B 211
VAL B 210
 None
 0.69A 4o2bC-1igjB:
undetectable		 4o2bC-1igjB:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igt IGG2A INTACT
ANTIBODY - MAB231

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 216
ALA B 211
VAL B 210
 None
 0.62A 4o2bC-1igtB:
undetectable		 4o2bC-1igtB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		3 SER B  64
ALA B  40
VAL B  39
 None
 0.59A 4o2bC-1jtdB:
undetectable		 4o2bC-1jtdB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzq MAJOR SURFACE
ANTIGEN P30

(Toxoplasma
gondii) 		PF04092
(SAG) 		3 SER A 133
ALA A 140
VAL A 139
 None
 0.65A 4o2bC-1kzqA:
undetectable		 4o2bC-1kzqA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpc DIANTHIN 30

(Dianthus
caryophyllus) 		PF00161
(RIP) 		3 SER A  64
ALA A  76
VAL A  75
 None
 0.69A 4o2bC-1lpcA:
undetectable		 4o2bC-1lpcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		3 SER A 782
ALA A 786
VAL A 789
 None
 0.62A 4o2bC-1lufA:
undetectable		 4o2bC-1lufA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwd ISOCITRATE
DEHYDROGENASE

(Sus scrofa) 		PF00180
(Iso_dh) 		3 SER A  69
ALA A  71
VAL A  72
 None
 0.69A 4o2bC-1lwdA:
undetectable		 4o2bC-1lwdA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		3 SER A  60
ALA A  58
VAL A 175
 None
 0.66A 4o2bC-1m33A:
3.2		 4o2bC-1m33A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnw HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		no annotation 3 SER A 194
ALA A 174
VAL A 173
 None
 0.66A 4o2bC-1nnwA:
undetectable		 4o2bC-1nnwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE

(Bacillus
intermedius) 		PF00089
(Trypsin) 		3 SER A 130
ALA A 174
VAL A 185
 None
 0.59A 4o2bC-1p3cA:
undetectable		 4o2bC-1p3cA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psk ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 203
ALA H 199
VAL H 198
 None
 0.68A 4o2bC-1pskH:
undetectable		 4o2bC-1pskH:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfd FAB M82G2, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.68A 4o2bC-1rfdH:
undetectable		 4o2bC-1rfdH:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spj KALLIKREIN 1

(Homo sapiens) 		PF00089
(Trypsin) 		3 SER A 226
ALA A 228
VAL A 229
 None
 0.54A 4o2bC-1spjA:
undetectable		 4o2bC-1spjA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		3 SER A  35
ALA A  33
VAL A  32
 None
 0.66A 4o2bC-1t6pA:
undetectable		 4o2bC-1t6pA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		3 SER A 239
ALA A 174
VAL A 173
 None
 0.60A 4o2bC-1t8hA:
undetectable		 4o2bC-1t8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uun MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		3 SER A  43
ALA A 143
VAL A 142
 None
 0.68A 4o2bC-1uunA:
undetectable		 4o2bC-1uunA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uus STAT PROTEIN

(Dictyostelium
discoideum) 		PF00017
(SH2)
PF09267
(Dict-STAT-coil) 		3 SER A 473
ALA A 363
VAL A 362
 None
 0.64A 4o2bC-1uusA:
undetectable		 4o2bC-1uusA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux4 BNI1 PROTEIN

(Saccharomyces
cerevisiae) 		PF02181
(FH2) 		3 SER A1527
ALA A1531
VAL A1534
 None
 0.68A 4o2bC-1ux4A:
undetectable		 4o2bC-1ux4A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpb PUTATIVE MODULATOR
OF DNA GYRASE

(Bacteroides
thetaiotaomicron) 		PF01523
(PmbA_TldD) 		3 SER A 428
ALA A 413
VAL A 412
 None
 0.64A 4o2bC-1vpbA:
undetectable		 4o2bC-1vpbA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		3 SER A 106
ALA A 104
VAL A 103
 None
 0.56A 4o2bC-1wdtA:
2.7		 4o2bC-1wdtA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		3 SER A 649
ALA A 626
VAL A 690
 None
 0.67A 4o2bC-1xf1A:
undetectable		 4o2bC-1xf1A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xov PLY PROTEIN

(Listeria virus
PSA) 		PF01520
(Amidase_3) 		3 SER A 185
ALA A 187
VAL A 188
 None
 0.41A 4o2bC-1xovA:
3.9		 4o2bC-1xovA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		3 SER A  48
ALA A  70
VAL A  75
 SO4  A 501 ( 3.9A)
None
None
 0.67A 4o2bC-1xviA:
2.8		 4o2bC-1xviA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xww LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Homo sapiens) 		PF01451
(LMWPc) 		3 SER A  43
ALA A  45
VAL A  46
 None
 0.66A 4o2bC-1xwwA:
2.9		 4o2bC-1xwwA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y30 HYPOTHETICAL PROTEIN
RV1155

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx) 		3 SER A 137
ALA A  82
VAL A  81
 None
 0.47A 4o2bC-1y30A:
undetectable		 4o2bC-1y30A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqq XANTHOSINE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		3 SER A  50
ALA A  48
VAL A  47
 None
 0.61A 4o2bC-1yqqA:
undetectable		 4o2bC-1yqqA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c94 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00885
(DMRL_synthase) 		3 SER A  25
ALA A  78
VAL A  77
 TSF  A 701 (-3.1A)
None
None
 0.68A 4o2bC-2c94A:
2.2		 4o2bC-2c94A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 SER A  47
ALA A  45
VAL A  44
 None
 0.50A 4o2bC-2e5vA:
2.1		 4o2bC-2e5vA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecr FLAVIN REDUCTASE
COMPONENT (HPAC) OF
4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		3 SER A  37
ALA A  46
VAL A 120
 None
 0.67A 4o2bC-2ecrA:
undetectable		 4o2bC-2ecrA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 SER A 304
ALA A 307
VAL A 308
 None
 0.68A 4o2bC-2ep5A:
undetectable		 4o2bC-2ep5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF00881
(Nitroreductase) 		3 SER A  86
ALA A 160
VAL A 159
 None
 0.49A 4o2bC-2freA:
undetectable		 4o2bC-2freA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuk XC6422 PROTEIN

(Xanthomonas
campestris) 		PF12146
(Hydrolase_4) 		3 SER A  10
ALA A  25
VAL A  24
 None
 0.62A 4o2bC-2fukA:
4.9		 4o2bC-2fukA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g60 ANTI-FLAG M2 FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.68A 4o2bC-2g60H:
undetectable		 4o2bC-2g60H:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfq UPF0204 PROTEIN
PH0006

(Pyrococcus
horikoshii) 		PF04414
(tRNA_deacylase) 		3 SER A 108
ALA A 110
VAL A 111
 None
 0.67A 4o2bC-2gfqA:
2.2		 4o2bC-2gfqA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h64 BONE MORPHOGENETIC
PROTEIN 2

(Homo sapiens) 		PF00019
(TGF_beta) 		3 SER A  88
ALA A  34
VAL A  33
 None
 0.59A 4o2bC-2h64A:
undetectable		 4o2bC-2h64A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf0 BILE SALT HYDROLASE

(Bifidobacterium
longum) 		PF02275
(CBAH) 		3 SER A 129
ALA A 100
VAL A  99
 None
 0.64A 4o2bC-2hf0A:
undetectable		 4o2bC-2hf0A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER D 213
ALA D 208
VAL D 207
 None
 0.59A 4o2bC-2hmiD:
undetectable		 4o2bC-2hmiD:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxs RAS-RELATED PROTEIN
RAB-28

(Homo sapiens) 		PF00071
(Ras) 		3 SER A 155
ALA A 125
VAL A 124
 None
 0.65A 4o2bC-2hxsA:
4.9		 4o2bC-2hxsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4s GENERAL SECRETION
PATHWAY PROTEIN C

(Vibrio cholerae) 		no annotation 3 SER A 289
ALA A 263
VAL A 262
 None
 0.62A 4o2bC-2i4sA:
undetectable		 4o2bC-2i4sA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iee PROBABLE ABC
TRANSPORTER
EXTRACELLULAR-BINDIN
G PROTEIN YCKB

(Bacillus
subtilis) 		PF00497
(SBP_bac_3) 		3 SER A  28
ALA A  26
VAL A  25
 None
 0.63A 4o2bC-2ieeA:
undetectable		 4o2bC-2ieeA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iks DNA-BINDING
TRANSCRIPTIONAL DUAL
REGULATOR

(Escherichia
coli) 		PF00532
(Peripla_BP_1) 		3 SER A 124
ALA A 146
VAL A 145
 None
 0.67A 4o2bC-2iksA:
undetectable		 4o2bC-2iksA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		3 SER A 356
ALA A 354
VAL A 353
 CSF  A1415 (-2.6A)
None
None
 0.58A 4o2bC-2iy8A:
5.4		 4o2bC-2iy8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 YDR362CP

(Saccharomyces
cerevisiae) 		no annotation 3 SER B 457
ALA B 446
VAL B 445
 None
 0.55A 4o2bC-2j04B:
undetectable		 4o2bC-2j04B:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ksm MYCOBACTERIUM
TUBERCULOSIS
RV0899/MT0922/OMPATB

(Mycobacterium
tuberculosis) 		PF04972
(BON) 		3 SER A 136
ALA A 138
VAL A 141
 None
 0.68A 4o2bC-2ksmA:
undetectable		 4o2bC-2ksmA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mfi 30S RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		PF00575
(S1) 		3 SER A  22
ALA A  71
VAL A  70
 None
 0.45A 4o2bC-2mfiA:
undetectable		 4o2bC-2mfiA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mlk RSTA

(Klebsiella
pneumoniae) 		PF00486
(Trans_reg_C) 		3 SER A 162
ALA A 160
VAL A 159
 None
 0.54A 4o2bC-2mlkA:
undetectable		 4o2bC-2mlkA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mou STAR-RELATED LIPID
TRANSFER PROTEIN 6

(Homo sapiens) 		PF01852
(START) 		3 SER A 100
ALA A 102
VAL A 103
 None
 0.65A 4o2bC-2mouA:
undetectable		 4o2bC-2mouA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obp PUTATIVE DNA-BINDING
PROTEIN

(Cupriavidus
pinatubonensis) 		no annotation 3 SER A  37
ALA A  77
VAL A  67
 None
 0.68A 4o2bC-2obpA:
undetectable		 4o2bC-2obpA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		3 SER D  17
ALA D  12
VAL D  11
 None
 0.66A 4o2bC-2ocfD:
undetectable		 4o2bC-2ocfD:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok0 FAB ED10 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.68A 4o2bC-2ok0H:
undetectable		 4o2bC-2ok0H:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qwu INTRACELLULAR GROWTH
LOCUS, SUBUNIT C

(Francisella
tularensis) 		PF11550
(IglC) 		3 SER A  40
ALA A  71
VAL A  93
 None
 0.68A 4o2bC-2qwuA:
undetectable		 4o2bC-2qwuA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz8 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN

(Mycobacterium
tuberculosis) 		PF01037
(AsnC_trans_reg)
PF13412
(HTH_24) 		3 SER A 105
ALA A  72
VAL A  71
 None
 0.55A 4o2bC-2qz8A:
undetectable		 4o2bC-2qz8A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9u MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		3 SER A  43
ALA A 143
VAL A 142
 SER  A  43 ( 0.0A)
ALA  A 143 ( 0.0A)
VAL  A 142 ( 0.5A)
 0.64A 4o2bC-2v9uA:
undetectable		 4o2bC-2v9uA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		3 SER A 173
ALA A 171
VAL A 170
 None
 0.62A 4o2bC-2vp3A:
2.0		 4o2bC-2vp3A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1v NITRILASE HOMOLOG 2

(Mus musculus) 		PF00795
(CN_hydrolase) 		3 SER A 260
ALA A 242
VAL A 241
 None
 0.63A 4o2bC-2w1vA:
undetectable		 4o2bC-2w1vA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		3 SER A 400
ALA A 398
VAL A 397
 None
 0.57A 4o2bC-2w9mA:
undetectable		 4o2bC-2w9mA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wba TRYPANOTHIONE
REDUCTASE

(Trypanosoma
brucei) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 SER A 475
ALA A 390
VAL A 389
 None
 0.65A 4o2bC-2wbaA:
undetectable		 4o2bC-2wbaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF13519
(VWA_2) 		3 SER A 320
ALA A 271
VAL A 270
 None
 0.67A 4o2bC-2ww8A:
undetectable		 4o2bC-2ww8A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xjq FLOCCULATION PROTEIN
FLO5

(Saccharomyces
cerevisiae) 		PF07691
(PA14) 		3 SER A  47
ALA A 225
VAL A 226
 None
None
NA  A1274 (-4.7A)
 0.60A 4o2bC-2xjqA:
undetectable		 4o2bC-2xjqA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy A13-D6.3 MONOCLONAL
ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER G 203
ALA G 198
VAL G 197
 None
 0.65A 4o2bC-2xqyG:
undetectable		 4o2bC-2xqyG:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyc NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		3 SER A 498
ALA A 571
VAL A 572
 None
 0.68A 4o2bC-2xycA:
undetectable		 4o2bC-2xycA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		3 SER A 224
ALA A 226
VAL A 227
 None
 0.66A 4o2bC-2yg1A:
undetectable		 4o2bC-2yg1A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE

(Streptococcus
pneumoniae) 		PF08305
(NPCBM) 		3 SER A 126
ALA A 124
VAL A 123
 None
 0.68A 4o2bC-2yglA:
undetectable		 4o2bC-2yglA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		3 SER A 934
ALA A 699
VAL A 687
 None
 0.60A 4o2bC-2yhaA:
2.2		 4o2bC-2yhaA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		3 SER A 934
ALA A 699
VAL A 687
 None
 0.61A 4o2bC-2yhbA:
2.0		 4o2bC-2yhbA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk1 FAB FRAGMENT, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  28
ALA H  94
VAL H  93
 None
None
NCT  H 300 (-4.3A)
 0.55A 4o2bC-2yk1H:
undetectable		 4o2bC-2yk1H:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 208
ALA B 203
VAL B 202
 None
 0.67A 4o2bC-2z4qB:
undetectable		 4o2bC-2z4qB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		3 SER A 167
ALA A 159
VAL A 158
 None
 0.61A 4o2bC-3aupA:
undetectable		 4o2bC-3aupA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0z FLAGELLAR
BIOSYNTHETIC PROTEIN
FLHB

(Salmonella
enterica) 		PF01312
(Bac_export_2) 		3 SER B 274
ALA B 291
VAL B 290
 None
 0.63A 4o2bC-3b0zB:
undetectable		 4o2bC-3b0zB:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE

(Homo sapiens) 		PF00198
(2-oxoacid_dh) 		3 SER A 430
ALA A 428
VAL A 427
 None
 0.52A 4o2bC-3b8kA:
undetectable		 4o2bC-3b8kA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9k FAB HEAVY CHAIN

(Rattus rattus) 		no annotation 3 SER H 216
ALA H 211
VAL H 210
 None
 0.68A 4o2bC-3b9kH:
undetectable		 4o2bC-3b9kH:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf8 ESTERASE YBFF

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		3 SER A  89
ALA A 111
VAL A 110
 MLA  A4892 (-3.2A)
None
None
 0.58A 4o2bC-3bf8A:
undetectable		 4o2bC-3bf8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cit SENSOR HISTIDINE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 3 SER A 138
ALA A 136
VAL A 135
 None
None
GOL  A 176 ( 4.8A)
 0.56A 4o2bC-3citA:
undetectable		 4o2bC-3citA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 SER A 360
ALA A 326
VAL A 327
 None
 0.68A 4o2bC-3dmkA:
undetectable		 4o2bC-3dmkA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpu RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF08477
(Roc)
PF16095
(COR) 		3 SER A 852
ALA A 847
VAL A 846
 None
 0.59A 4o2bC-3dpuA:
undetectable		 4o2bC-3dpuA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ds8 LIN2722 PROTEIN

(Listeria
innocua) 		PF06028
(DUF915) 		3 SER A 102
ALA A 129
VAL A 128
 SO4  A 255 (-2.2A)
None
None
 0.52A 4o2bC-3ds8A:
4.2		 4o2bC-3ds8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epm THIAMINE
BIOSYNTHESIS PROTEIN
THIC

(Caulobacter
vibrioides) 		PF01964
(ThiC_Rad_SAM)
PF13667
(ThiC-associated) 		3 SER A  22
ALA A  43
VAL A  44
 None
 0.65A 4o2bC-3epmA:
undetectable		 4o2bC-3epmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 SER A  73
ALA A  99
VAL A 158
 PO4  A 614 ( 3.9A)
None
None
 0.54A 4o2bC-3eyaA:
2.8		 4o2bC-3eyaA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 SER A 183
ALA A 185
VAL A 186
 None
 0.64A 4o2bC-3gd5A:
undetectable		 4o2bC-3gd5A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		3 SER A  21
ALA A  72
VAL A  97
 RIB  A 305 ( 4.7A)
None
None
 0.60A 4o2bC-3go7A:
4.2		 4o2bC-3go7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A

(Bartonella
henselae) 		PF06026
(Rib_5-P_isom_A) 		3 SER A 245
ALA A 241
VAL A 240
 None
 0.52A 4o2bC-3hheA:
undetectable		 4o2bC-3hheA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzg THYMIDYLATE SYNTHASE
THYX

(Mycobacterium
tuberculosis) 		PF02511
(Thy1) 		3 SER A 201
ALA A 242
VAL A 232
 None
 0.64A 4o2bC-3hzgA:
undetectable		 4o2bC-3hzgA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if1 IMMUNOGLOBULIN HEAVY
CHAIN (IGG2A)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 203
ALA B 198
VAL B 197
 None
 0.69A 4o2bC-3if1B:
undetectable		 4o2bC-3if1B:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 SER A 334
ALA A 332
VAL A 331
 None
 0.69A 4o2bC-3iveA:
undetectable		 4o2bC-3iveA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		3 SER A 142
ALA A 113
VAL A 112
 None
 0.68A 4o2bC-3k9dA:
undetectable		 4o2bC-3k9dA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kk4 UNCHARACTERIZED
PROTEIN BP1543

(Bordetella
pertussis) 		PF13467
(RHH_4) 		3 SER A  28
ALA A  26
VAL A  25
 None
 0.60A 4o2bC-3kk4A:
undetectable		 4o2bC-3kk4A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpt COLLAGEN ADHESION
PROTEIN

(Bacillus cereus) 		no annotation 3 SER A 244
ALA A 169
VAL A 170
 None
 0.59A 4o2bC-3kptA:
undetectable		 4o2bC-3kptA:
22.29