SIMILAR PATTERNS OF AMINO ACIDS FOR 4O2B_D_LOCD503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aog TRYPANOTHIONE
REDUCTASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 SER A 475
ALA A 390
VAL A 389
 None
 0.64A 4o2bC-1aogA:
2.1		 4o2bC-1aogA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at0 17-HEDGEHOG

(Drosophila
melanogaster) 		PF01079
(Hint) 		3 SER A 399
ALA A 397
VAL A 396
 None
 0.52A 4o2bC-1at0A:
undetectable		 4o2bC-1at0A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b89 PROTEIN (CLATHRIN
HEAVY CHAIN)

(Bos taurus) 		PF00637
(Clathrin) 		3 SER A1229
ALA A1240
VAL A1241
 None
 0.68A 4o2bC-1b89A:
undetectable		 4o2bC-1b89A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		3 SER M  36
ALA M  34
VAL M  33
 GOL  M 936 ( 4.5A)
None
None
 0.63A 4o2bC-1dwaM:
1.5		 4o2bC-1dwaM:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1etz FAB NC10.14 - HEAVY
CHAIN

(Mus musculus) 		no annotation 3 SER H 216
ALA H 211
VAL H 210
 None
 0.62A 4o2bC-1etzH:
undetectable		 4o2bC-1etzH:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3

(Rattus
norvegicus) 		PF06325
(PrmA) 		3 SER A 368
ALA A 366
VAL A 365
 None
 0.54A 4o2bC-1f3lA:
undetectable		 4o2bC-1f3lA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f89 32.5 KDA PROTEIN
YLR351C

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		3 SER A 238
ALA A 249
VAL A 248
 None
 0.62A 4o2bC-1f89A:
undetectable		 4o2bC-1f89A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.61A 4o2bC-1fptH:
undetectable		 4o2bC-1fptH:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hq8 NKG2-D

(Mus musculus) 		PF00059
(Lectin_C) 		3 SER A 204
ALA A 206
VAL A 207
 None
 0.68A 4o2bC-1hq8A:
undetectable		 4o2bC-1hq8A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli) 		PF00923
(TAL_FSA) 		3 SER A  94
ALA A  96
VAL A  97
 None
 0.62A 4o2bC-1i2oA:
undetectable		 4o2bC-1i2oA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		3 SER A 329
ALA A 388
VAL A 387
 None
 0.64A 4o2bC-1i5pA:
undetectable		 4o2bC-1i5pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibg IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.58A 4o2bC-1ibgH:
undetectable		 4o2bC-1ibgH:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibx CHIMERA OF IGG
BINDING PROTEIN G
AND DNA
FRAGMENTATION FACTOR
45

(Homo sapiens;
Streptococcus
sp.) 		PF02017
(CIDE-N) 		3 SER B  37
ALA B  35
VAL B  34
 None
 0.64A 4o2bC-1ibxB:
undetectable		 4o2bC-1ibxB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igj IGG2A-KAPPA 26-10
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 216
ALA B 211
VAL B 210
 None
 0.69A 4o2bC-1igjB:
undetectable		 4o2bC-1igjB:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igt IGG2A INTACT
ANTIBODY - MAB231

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 216
ALA B 211
VAL B 210
 None
 0.62A 4o2bC-1igtB:
undetectable		 4o2bC-1igtB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		3 SER B  64
ALA B  40
VAL B  39
 None
 0.59A 4o2bC-1jtdB:
undetectable		 4o2bC-1jtdB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzq MAJOR SURFACE
ANTIGEN P30

(Toxoplasma
gondii) 		PF04092
(SAG) 		3 SER A 133
ALA A 140
VAL A 139
 None
 0.65A 4o2bC-1kzqA:
undetectable		 4o2bC-1kzqA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpc DIANTHIN 30

(Dianthus
caryophyllus) 		PF00161
(RIP) 		3 SER A  64
ALA A  76
VAL A  75
 None
 0.69A 4o2bC-1lpcA:
undetectable		 4o2bC-1lpcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		3 SER A 782
ALA A 786
VAL A 789
 None
 0.62A 4o2bC-1lufA:
undetectable		 4o2bC-1lufA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwd ISOCITRATE
DEHYDROGENASE

(Sus scrofa) 		PF00180
(Iso_dh) 		3 SER A  69
ALA A  71
VAL A  72
 None
 0.69A 4o2bC-1lwdA:
undetectable		 4o2bC-1lwdA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		3 SER A  60
ALA A  58
VAL A 175
 None
 0.66A 4o2bC-1m33A:
3.2		 4o2bC-1m33A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnw HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		no annotation 3 SER A 194
ALA A 174
VAL A 173
 None
 0.66A 4o2bC-1nnwA:
undetectable		 4o2bC-1nnwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE

(Bacillus
intermedius) 		PF00089
(Trypsin) 		3 SER A 130
ALA A 174
VAL A 185
 None
 0.59A 4o2bC-1p3cA:
undetectable		 4o2bC-1p3cA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psk ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 203
ALA H 199
VAL H 198
 None
 0.68A 4o2bC-1pskH:
undetectable		 4o2bC-1pskH:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfd FAB M82G2, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.68A 4o2bC-1rfdH:
undetectable		 4o2bC-1rfdH:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spj KALLIKREIN 1

(Homo sapiens) 		PF00089
(Trypsin) 		3 SER A 226
ALA A 228
VAL A 229
 None
 0.54A 4o2bC-1spjA:
undetectable		 4o2bC-1spjA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		3 SER A  35
ALA A  33
VAL A  32
 None
 0.66A 4o2bC-1t6pA:
undetectable		 4o2bC-1t6pA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		3 SER A 239
ALA A 174
VAL A 173
 None
 0.60A 4o2bC-1t8hA:
undetectable		 4o2bC-1t8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uun MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		3 SER A  43
ALA A 143
VAL A 142
 None
 0.68A 4o2bC-1uunA:
undetectable		 4o2bC-1uunA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uus STAT PROTEIN

(Dictyostelium
discoideum) 		PF00017
(SH2)
PF09267
(Dict-STAT-coil) 		3 SER A 473
ALA A 363
VAL A 362
 None
 0.64A 4o2bC-1uusA:
undetectable		 4o2bC-1uusA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux4 BNI1 PROTEIN

(Saccharomyces
cerevisiae) 		PF02181
(FH2) 		3 SER A1527
ALA A1531
VAL A1534
 None
 0.68A 4o2bC-1ux4A:
undetectable		 4o2bC-1ux4A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpb PUTATIVE MODULATOR
OF DNA GYRASE

(Bacteroides
thetaiotaomicron) 		PF01523
(PmbA_TldD) 		3 SER A 428
ALA A 413
VAL A 412
 None
 0.64A 4o2bC-1vpbA:
undetectable		 4o2bC-1vpbA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		3 SER A 106
ALA A 104
VAL A 103
 None
 0.56A 4o2bC-1wdtA:
2.7		 4o2bC-1wdtA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		3 SER A 649
ALA A 626
VAL A 690
 None
 0.67A 4o2bC-1xf1A:
undetectable		 4o2bC-1xf1A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xov PLY PROTEIN

(Listeria virus
PSA) 		PF01520
(Amidase_3) 		3 SER A 185
ALA A 187
VAL A 188
 None
 0.41A 4o2bC-1xovA:
3.9		 4o2bC-1xovA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		3 SER A  48
ALA A  70
VAL A  75
 SO4  A 501 ( 3.9A)
None
None
 0.67A 4o2bC-1xviA:
2.8		 4o2bC-1xviA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xww LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Homo sapiens) 		PF01451
(LMWPc) 		3 SER A  43
ALA A  45
VAL A  46
 None
 0.66A 4o2bC-1xwwA:
2.9		 4o2bC-1xwwA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y30 HYPOTHETICAL PROTEIN
RV1155

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx) 		3 SER A 137
ALA A  82
VAL A  81
 None
 0.47A 4o2bC-1y30A:
undetectable		 4o2bC-1y30A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqq XANTHOSINE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		3 SER A  50
ALA A  48
VAL A  47
 None
 0.61A 4o2bC-1yqqA:
undetectable		 4o2bC-1yqqA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c94 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00885
(DMRL_synthase) 		3 SER A  25
ALA A  78
VAL A  77
 TSF  A 701 (-3.1A)
None
None
 0.68A 4o2bC-2c94A:
2.2		 4o2bC-2c94A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 SER A  47
ALA A  45
VAL A  44
 None
 0.50A 4o2bC-2e5vA:
2.1		 4o2bC-2e5vA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecr FLAVIN REDUCTASE
COMPONENT (HPAC) OF
4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		3 SER A  37
ALA A  46
VAL A 120
 None
 0.67A 4o2bC-2ecrA:
undetectable		 4o2bC-2ecrA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 SER A 304
ALA A 307
VAL A 308
 None
 0.68A 4o2bC-2ep5A:
undetectable		 4o2bC-2ep5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF00881
(Nitroreductase) 		3 SER A  86
ALA A 160
VAL A 159
 None
 0.49A 4o2bC-2freA:
undetectable		 4o2bC-2freA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuk XC6422 PROTEIN

(Xanthomonas
campestris) 		PF12146
(Hydrolase_4) 		3 SER A  10
ALA A  25
VAL A  24
 None
 0.62A 4o2bC-2fukA:
4.9		 4o2bC-2fukA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g60 ANTI-FLAG M2 FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.68A 4o2bC-2g60H:
undetectable		 4o2bC-2g60H:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfq UPF0204 PROTEIN
PH0006

(Pyrococcus
horikoshii) 		PF04414
(tRNA_deacylase) 		3 SER A 108
ALA A 110
VAL A 111
 None
 0.67A 4o2bC-2gfqA:
2.2		 4o2bC-2gfqA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h64 BONE MORPHOGENETIC
PROTEIN 2

(Homo sapiens) 		PF00019
(TGF_beta) 		3 SER A  88
ALA A  34
VAL A  33
 None
 0.59A 4o2bC-2h64A:
undetectable		 4o2bC-2h64A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf0 BILE SALT HYDROLASE

(Bifidobacterium
longum) 		PF02275
(CBAH) 		3 SER A 129
ALA A 100
VAL A  99
 None
 0.64A 4o2bC-2hf0A:
undetectable		 4o2bC-2hf0A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER D 213
ALA D 208
VAL D 207
 None
 0.59A 4o2bC-2hmiD:
undetectable		 4o2bC-2hmiD:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxs RAS-RELATED PROTEIN
RAB-28

(Homo sapiens) 		PF00071
(Ras) 		3 SER A 155
ALA A 125
VAL A 124
 None
 0.65A 4o2bC-2hxsA:
4.9		 4o2bC-2hxsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4s GENERAL SECRETION
PATHWAY PROTEIN C

(Vibrio cholerae) 		no annotation 3 SER A 289
ALA A 263
VAL A 262
 None
 0.62A 4o2bC-2i4sA:
undetectable		 4o2bC-2i4sA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iee PROBABLE ABC
TRANSPORTER
EXTRACELLULAR-BINDIN
G PROTEIN YCKB

(Bacillus
subtilis) 		PF00497
(SBP_bac_3) 		3 SER A  28
ALA A  26
VAL A  25
 None
 0.63A 4o2bC-2ieeA:
undetectable		 4o2bC-2ieeA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iks DNA-BINDING
TRANSCRIPTIONAL DUAL
REGULATOR

(Escherichia
coli) 		PF00532
(Peripla_BP_1) 		3 SER A 124
ALA A 146
VAL A 145
 None
 0.67A 4o2bC-2iksA:
undetectable		 4o2bC-2iksA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		3 SER A 356
ALA A 354
VAL A 353
 CSF  A1415 (-2.6A)
None
None
 0.58A 4o2bC-2iy8A:
5.4		 4o2bC-2iy8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 YDR362CP

(Saccharomyces
cerevisiae) 		no annotation 3 SER B 457
ALA B 446
VAL B 445
 None
 0.55A 4o2bC-2j04B:
undetectable		 4o2bC-2j04B:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ksm MYCOBACTERIUM
TUBERCULOSIS
RV0899/MT0922/OMPATB

(Mycobacterium
tuberculosis) 		PF04972
(BON) 		3 SER A 136
ALA A 138
VAL A 141
 None
 0.68A 4o2bC-2ksmA:
undetectable		 4o2bC-2ksmA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mfi 30S RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		PF00575
(S1) 		3 SER A  22
ALA A  71
VAL A  70
 None
 0.45A 4o2bC-2mfiA:
undetectable		 4o2bC-2mfiA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mlk RSTA

(Klebsiella
pneumoniae) 		PF00486
(Trans_reg_C) 		3 SER A 162
ALA A 160
VAL A 159
 None
 0.54A 4o2bC-2mlkA:
undetectable		 4o2bC-2mlkA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mou STAR-RELATED LIPID
TRANSFER PROTEIN 6

(Homo sapiens) 		PF01852
(START) 		3 SER A 100
ALA A 102
VAL A 103
 None
 0.65A 4o2bC-2mouA:
undetectable		 4o2bC-2mouA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obp PUTATIVE DNA-BINDING
PROTEIN

(Cupriavidus
pinatubonensis) 		no annotation 3 SER A  37
ALA A  77
VAL A  67
 None
 0.68A 4o2bC-2obpA:
undetectable		 4o2bC-2obpA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		3 SER D  17
ALA D  12
VAL D  11
 None
 0.66A 4o2bC-2ocfD:
undetectable		 4o2bC-2ocfD:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok0 FAB ED10 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H 216
ALA H 211
VAL H 210
 None
 0.68A 4o2bC-2ok0H:
undetectable		 4o2bC-2ok0H:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qwu INTRACELLULAR GROWTH
LOCUS, SUBUNIT C

(Francisella
tularensis) 		PF11550
(IglC) 		3 SER A  40
ALA A  71
VAL A  93
 None
 0.68A 4o2bC-2qwuA:
undetectable		 4o2bC-2qwuA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz8 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN

(Mycobacterium
tuberculosis) 		PF01037
(AsnC_trans_reg)
PF13412
(HTH_24) 		3 SER A 105
ALA A  72
VAL A  71
 None
 0.55A 4o2bC-2qz8A:
undetectable		 4o2bC-2qz8A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9u MSPA

(Mycolicibacterium
smegmatis) 		PF09203
(MspA) 		3 SER A  43
ALA A 143
VAL A 142
 SER  A  43 ( 0.0A)
ALA  A 143 ( 0.0A)
VAL  A 142 ( 0.5A)
 0.64A 4o2bC-2v9uA:
undetectable		 4o2bC-2v9uA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		3 SER A 173
ALA A 171
VAL A 170
 None
 0.62A 4o2bC-2vp3A:
2.0		 4o2bC-2vp3A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1v NITRILASE HOMOLOG 2

(Mus musculus) 		PF00795
(CN_hydrolase) 		3 SER A 260
ALA A 242
VAL A 241
 None
 0.63A 4o2bC-2w1vA:
undetectable		 4o2bC-2w1vA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		3 SER A 400
ALA A 398
VAL A 397
 None
 0.57A 4o2bC-2w9mA:
undetectable		 4o2bC-2w9mA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wba TRYPANOTHIONE
REDUCTASE

(Trypanosoma
brucei) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 SER A 475
ALA A 390
VAL A 389
 None
 0.65A 4o2bC-2wbaA:
undetectable		 4o2bC-2wbaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF13519
(VWA_2) 		3 SER A 320
ALA A 271
VAL A 270
 None
 0.67A 4o2bC-2ww8A:
undetectable		 4o2bC-2ww8A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xjq FLOCCULATION PROTEIN
FLO5

(Saccharomyces
cerevisiae) 		PF07691
(PA14) 		3 SER A  47
ALA A 225
VAL A 226
 None
None
NA  A1274 (-4.7A)
 0.60A 4o2bC-2xjqA:
undetectable		 4o2bC-2xjqA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy A13-D6.3 MONOCLONAL
ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER G 203
ALA G 198
VAL G 197
 None
 0.65A 4o2bC-2xqyG:
undetectable		 4o2bC-2xqyG:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyc NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		3 SER A 498
ALA A 571
VAL A 572
 None
 0.68A 4o2bC-2xycA:
undetectable		 4o2bC-2xycA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		3 SER A 224
ALA A 226
VAL A 227
 None
 0.66A 4o2bC-2yg1A:
undetectable		 4o2bC-2yg1A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE

(Streptococcus
pneumoniae) 		PF08305
(NPCBM) 		3 SER A 126
ALA A 124
VAL A 123
 None
 0.68A 4o2bC-2yglA:
undetectable		 4o2bC-2yglA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		3 SER A 934
ALA A 699
VAL A 687
 None
 0.60A 4o2bC-2yhaA:
2.2		 4o2bC-2yhaA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		3 SER A 934
ALA A 699
VAL A 687
 None
 0.61A 4o2bC-2yhbA:
2.0		 4o2bC-2yhbA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk1 FAB FRAGMENT, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER H  28
ALA H  94
VAL H  93
 None
None
NCT  H 300 (-4.3A)
 0.55A 4o2bC-2yk1H:
undetectable		 4o2bC-2yk1H:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 208
ALA B 203
VAL B 202
 None
 0.67A 4o2bC-2z4qB:
undetectable		 4o2bC-2z4qB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		3 SER A 167
ALA A 159
VAL A 158
 None
 0.61A 4o2bC-3aupA:
undetectable		 4o2bC-3aupA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0z FLAGELLAR
BIOSYNTHETIC PROTEIN
FLHB

(Salmonella
enterica) 		PF01312
(Bac_export_2) 		3 SER B 274
ALA B 291
VAL B 290
 None
 0.63A 4o2bC-3b0zB:
undetectable		 4o2bC-3b0zB:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE

(Homo sapiens) 		PF00198
(2-oxoacid_dh) 		3 SER A 430
ALA A 428
VAL A 427
 None
 0.52A 4o2bC-3b8kA:
undetectable		 4o2bC-3b8kA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9k FAB HEAVY CHAIN

(Rattus rattus) 		no annotation 3 SER H 216
ALA H 211
VAL H 210
 None
 0.68A 4o2bC-3b9kH:
undetectable		 4o2bC-3b9kH:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf8 ESTERASE YBFF

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		3 SER A  89
ALA A 111
VAL A 110
 MLA  A4892 (-3.2A)
None
None
 0.58A 4o2bC-3bf8A:
undetectable		 4o2bC-3bf8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cit SENSOR HISTIDINE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 3 SER A 138
ALA A 136
VAL A 135
 None
None
GOL  A 176 ( 4.8A)
 0.56A 4o2bC-3citA:
undetectable		 4o2bC-3citA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 SER A 360
ALA A 326
VAL A 327
 None
 0.68A 4o2bC-3dmkA:
undetectable		 4o2bC-3dmkA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpu RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF08477
(Roc)
PF16095
(COR) 		3 SER A 852
ALA A 847
VAL A 846
 None
 0.59A 4o2bC-3dpuA:
undetectable		 4o2bC-3dpuA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ds8 LIN2722 PROTEIN

(Listeria
innocua) 		PF06028
(DUF915) 		3 SER A 102
ALA A 129
VAL A 128
 SO4  A 255 (-2.2A)
None
None
 0.52A 4o2bC-3ds8A:
4.2		 4o2bC-3ds8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epm THIAMINE
BIOSYNTHESIS PROTEIN
THIC

(Caulobacter
vibrioides) 		PF01964
(ThiC_Rad_SAM)
PF13667
(ThiC-associated) 		3 SER A  22
ALA A  43
VAL A  44
 None
 0.65A 4o2bC-3epmA:
undetectable		 4o2bC-3epmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 SER A  73
ALA A  99
VAL A 158
 PO4  A 614 ( 3.9A)
None
None
 0.54A 4o2bC-3eyaA:
2.8		 4o2bC-3eyaA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 SER A 183
ALA A 185
VAL A 186
 None
 0.64A 4o2bC-3gd5A:
undetectable		 4o2bC-3gd5A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		3 SER A  21
ALA A  72
VAL A  97
 RIB  A 305 ( 4.7A)
None
None
 0.60A 4o2bC-3go7A:
4.2		 4o2bC-3go7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A

(Bartonella
henselae) 		PF06026
(Rib_5-P_isom_A) 		3 SER A 245
ALA A 241
VAL A 240
 None
 0.52A 4o2bC-3hheA:
undetectable		 4o2bC-3hheA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzg THYMIDYLATE SYNTHASE
THYX

(Mycobacterium
tuberculosis) 		PF02511
(Thy1) 		3 SER A 201
ALA A 242
VAL A 232
 None
 0.64A 4o2bC-3hzgA:
undetectable		 4o2bC-3hzgA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if1 IMMUNOGLOBULIN HEAVY
CHAIN (IGG2A)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER B 203
ALA B 198
VAL B 197
 None
 0.69A 4o2bC-3if1B:
undetectable		 4o2bC-3if1B:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 SER A 334
ALA A 332
VAL A 331
 None
 0.69A 4o2bC-3iveA:
undetectable		 4o2bC-3iveA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		3 SER A 142
ALA A 113
VAL A 112
 None
 0.68A 4o2bC-3k9dA:
undetectable		 4o2bC-3k9dA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kk4 UNCHARACTERIZED
PROTEIN BP1543

(Bordetella
pertussis) 		PF13467
(RHH_4) 		3 SER A  28
ALA A  26
VAL A  25
 None
 0.60A 4o2bC-3kk4A:
undetectable		 4o2bC-3kk4A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpt COLLAGEN ADHESION
PROTEIN

(Bacillus cereus) 		no annotation 3 SER A 244
ALA A 169
VAL A 170
 None
 0.59A 4o2bC-3kptA:
undetectable		 4o2bC-3kptA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		6 LEU A 225
LEU A 450
ALA A 227
ILE A 254
ALA A 265
ILE A 463
 None
 1.31A 4o2bD-1br2A:
undetectable		 4o2bD-1br2A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpc C-PHYCOCYANIN (BETA
SUBUNIT)

(Microchaete
diplosiphon) 		PF00502
(Phycobilisome) 		5 LEU B 107
ALA B 169
ILE B  99
ALA B  98
ILE B  44
 None
 0.97A 4o2bD-1cpcB:
undetectable		 4o2bD-1cpcB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		6 LEU A 197
THR A 241
ALA A 239
ILE A   3
ALA A 226
ILE A 236
 None
 1.17A 4o2bD-1f6yA:
2.4		 4o2bD-1f6yA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g61 TRANSLATION
INITIATION FACTOR 6

(Methanocaldococcus
jannaschii) 		PF01912
(eIF-6) 		5 LEU A2020
LEU A2107
LEU A2070
ILE A2053
ILE A2084
 None
 0.98A 4o2bD-1g61A:
undetectable		 4o2bD-1g61A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		5 LEU A 512
ALA A 293
LEU A 291
ALA A 444
ILE A 390
 None
 0.96A 4o2bD-1gz4A:
3.8		 4o2bD-1gz4A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6u INTERNALIN H

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		6 LEU A 103
ALA A  83
LEU A  53
ILE A  78
LYS A  58
ALA A  60
 None
 0.94A 4o2bD-1h6uA:
undetectable		 4o2bD-1h6uA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		5 LEU S 450
ALA S 227
ILE S 254
ALA S 265
ILE S 463
 None
 0.86A 4o2bD-1i84S:
undetectable		 4o2bD-1i84S:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8a ENDO-1,4-BETA-XYLANA
SE A

(Thermotoga
maritima) 		PF06452
(CBM9_1) 		5 LEU A  52
LEU A 184
ASN A 183
ILE A 150
ILE A  25
 None
 0.95A 4o2bD-1i8aA:
undetectable		 4o2bD-1i8aA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU) 		5 CYH A 193
ALA A 159
ILE A 486
ALA A 419
ILE A 490
 None
 0.96A 4o2bD-1iwpA:
undetectable		 4o2bD-1iwpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		5 ALA A 256
ASN A 167
ALA A  52
ILE A 236
ALA A 160
 None
 0.94A 4o2bD-1j33A:
3.5		 4o2bD-1j33A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II

(Thermus
thermophilus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 206
LEU A  44
ILE A  36
ALA A  41
ILE A 192
 None
 0.96A 4o2bD-1j3nA:
undetectable		 4o2bD-1j3nA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		5 CYH A 227
LEU A  55
ALA A 100
ALA A  30
ILE A 126
 None
 0.86A 4o2bD-1kyhA:
3.0		 4o2bD-1kyhA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0q SURFACE LAYER
PROTEIN

(Methanosarcina
mazei) 		PF00801
(PKD)
PF10282
(Lactonase) 		5 THR A   2
ALA A   4
ILE A   6
ALA A 290
ILE A  17
 None
 0.84A 4o2bD-1l0qA:
undetectable		 4o2bD-1l0qA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		5 LEU A 286
ALA A 259
ASN A 254
ALA A 234
ILE A 231
 None
 0.87A 4o2bD-1l8wA:
undetectable		 4o2bD-1l8wA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A

(Thermobifida
fusca) 		PF00079
(Serpin) 		5 LEU A 145
THR A 298
ALA A 319
ALA A 317
ILE A 157
 None
 0.85A 4o2bD-1mtpA:
undetectable		 4o2bD-1mtpA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 LEU A1365
ALA A1392
ILE A1394
ALA A1375
ILE A1410
 None
 0.97A 4o2bD-1ofeA:
undetectable		 4o2bD-1ofeA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 LEU A  50
ALA A  39
ILE A  34
ALA A  64
ILE A   3
 None
 0.95A 4o2bD-1ptjA:
3.9		 4o2bD-1ptjA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli) 		PF00294
(PfkB) 		5 LEU A   7
ALA A  51
ALA A 164
ALA A 137
ILE A 183
 None
 0.95A 4o2bD-1rk2A:
5.1		 4o2bD-1rk2A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli) 		PF00294
(PfkB) 		6 LEU A   7
ALA A  56
ALA A 164
ILE A 162
ALA A 137
ILE A 183
 None
 1.39A 4o2bD-1rk2A:
5.1		 4o2bD-1rk2A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkv HOMOSERINE KINASE

(Pseudomonas
aeruginosa) 		PF12710
(HAD) 		5 LEU A  80
LEU A 191
ALA A 150
ILE A 148
ALA A   4
 None
 0.96A 4o2bD-1rkvA:
3.6		 4o2bD-1rkvA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkv HOMOSERINE KINASE

(Pseudomonas
aeruginosa) 		PF12710
(HAD) 		5 LEU A 191
ALA A 150
ILE A 148
ALA A   4
ILE A 167
 None
 0.92A 4o2bD-1rkvA:
3.6		 4o2bD-1rkvA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5l PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE

(Thermosynechococcus
elongatus) 		PF01716
(MSP) 		6 LEU O  93
ALA O 127
ALA O 241
ILE O 243
ALA O  41
ILE O 211
 None
 1.36A 4o2bD-1s5lO:
undetectable		 4o2bD-1s5lO:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szq 2-METHYLCITRATE
DEHYDRATASE

(Escherichia
coli) 		PF03972
(MmgE_PrpD) 		6 LEU A 379
LEU A 409
THR A 302
ALA A 300
ALA A 353
ILE A 407
 None
 1.49A 4o2bD-1szqA:
undetectable		 4o2bD-1szqA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		5 ALA A 149
LEU A 147
ALA A 107
ILE A  69
ALA A  91
 None
 0.92A 4o2bD-1ur4A:
3.1		 4o2bD-1ur4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47) 		PF00544
(Pec_lyase_C) 		5 LEU A  69
LEU A  41
ILE A 163
ALA A 143
ILE A 136
 None
 0.97A 4o2bD-1vblA:
undetectable		 4o2bD-1vblA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 LEU A 517
LEU A 511
ALA A 495
THR A 609
ALA A 611
 None
 0.94A 4o2bD-1w99A:
undetectable		 4o2bD-1w99A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcr HYPOTHETICAL PROTEIN
PTD012

(Homo sapiens) 		PF08925
(DUF1907) 		5 CYH A 140
LEU A 142
THR A 267
ILE A 218
ALA A 131
 None
 0.95A 4o2bD-1xcrA:
undetectable		 4o2bD-1xcrA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF01717
(Meth_synt_2) 		5 LEU A 186
ALA A 224
ILE A 173
ALA A 172
ILE A 225
 None
 0.98A 4o2bD-1ypxA:
2.8		 4o2bD-1ypxA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aie PEPTIDE DEFORMYLASE

(Streptococcus
pneumoniae) 		PF01327
(Pep_deformylase) 		5 LEU P  77
ALA P  85
ILE P  83
ALA P  74
ILE P 107
 None
 0.82A 4o2bD-2aieP:
undetectable		 4o2bD-2aieP:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc1 L-ASPARTATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF01958
(DUF108)
PF03447
(NAD_binding_3) 		5 LEU A  80
ALA A  57
LEU A  15
ILE A 226
ALA A 108
 NAD  A 242 (-4.1A)
NAD  A 242 ( 4.9A)
None
None
None
 0.97A 4o2bD-2dc1A:
undetectable		 4o2bD-2dc1A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1r DIMETHYLADENOSINE
TRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00398
(RrnaAD) 		5 LEU A 173
LEU A 101
ALA A  91
ALA A 115
ILE A  28
 None
 0.83A 4o2bD-2h1rA:
undetectable		 4o2bD-2h1rA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		5 LEU A  84
ALA A  73
ILE A   6
ALA A  91
ILE A 290
 None
 0.95A 4o2bD-2ivpA:
undetectable		 4o2bD-2ivpA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m1x TIR
DOMAIN-CONTAINING
ADAPTER MOLECULE 1

(Homo sapiens) 		no annotation 5 LEU A 533
LEU A 416
THR A 426
ALA A 450
ILE A 453
 None
 0.88A 4o2bD-2m1xA:
2.5		 4o2bD-2m1xA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 338
ALA A 336
ALA A 361
ALA A 342
ILE A 378
 None
 0.82A 4o2bD-2oi6A:
undetectable		 4o2bD-2oi6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.89A 4o2bD-2oi6A:
undetectable		 4o2bD-2oi6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A 208
LEU A 151
THR A 127
ALA A 224
ILE A 185
 None
 0.78A 4o2bD-2qo3A:
undetectable		 4o2bD-2qo3A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsj DNA-BINDING RESPONSE
REGULATOR, LUXR
FAMILY

(Ruegeria
pomeroyi) 		PF00072
(Response_reg) 		5 ALA A  41
LEU A  43
ASN A  47
ALA A  33
ILE A  52
 None
 0.97A 4o2bD-2qsjA:
undetectable		 4o2bD-2qsjA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Pseudomonas
syringae group
genomosp. 3) 		PF04198
(Sugar-bind) 		5 LEU A 283
ALA A 100
LEU A 104
ILE A 116
ILE A 114
 None
 0.97A 4o2bD-2r5fA:
undetectable		 4o2bD-2r5fA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 167
LEU A  65
ALA A 123
ILE A 125
ILE A  76
 None
 0.89A 4o2bD-2v7bA:
undetectable		 4o2bD-2v7bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbi PYRUVATE
DECARBOXYLASE

(Acetobacter
pasteurianus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 LEU A 331
LEU A 324
ALA A 307
LEU A 281
THR A 241
ALA A 225
 None
 1.26A 4o2bD-2vbiA:
undetectable		 4o2bD-2vbiA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		6 CYH A  72
LEU A  69
THR A 212
ILE A  35
ALA A  80
ILE A 210
 None
 1.42A 4o2bD-2vfwA:
undetectable		 4o2bD-2vfwA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 LEU A 203
ASN A 205
ILE A 103
ALA A 187
ILE A  73
 None
 0.99A 4o2bD-2vxoA:
undetectable		 4o2bD-2vxoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Bacillus
subtilis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 ALA A 164
LEU A 166
ILE A 140
ALA A 156
ILE A 184
 None
 0.93A 4o2bD-2xd4A:
undetectable		 4o2bD-2xd4A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]

(Methanocaldococcus
jannaschii) 		PF13847
(Methyltransf_31) 		5 THR A 131
ALA A 129
ILE A 127
ALA A 181
ILE A 106
 None
 0.78A 4o2bD-2yxdA:
3.2		 4o2bD-2yxdA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		5 LEU A  32
ALA A  59
ILE A 194
ALA A  42
ILE A  46
 None
 0.91A 4o2bD-2zj8A:
undetectable		 4o2bD-2zj8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		5 LEU A 316
LEU A 373
THR A 123
ILE A 380
ALA A 377
 None
 0.96A 4o2bD-3aflA:
undetectable		 4o2bD-3aflA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgw DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		6 LEU A 357
LEU A 317
LEU A 374
ALA A 384
ALA A 353
ILE A 387
 None
 1.44A 4o2bD-3bgwA:
undetectable		 4o2bD-3bgwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 LEU A   9
ALA A  63
ILE A  65
ALA A  70
ILE A  32
 None
 0.64A 4o2bD-3ctzA:
undetectable		 4o2bD-3ctzA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A 220
ALA A 151
ILE A 149
ALA A 228
ILE A 242
 None
 0.94A 4o2bD-3db2A:
4.5		 4o2bD-3db2A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddu PROLYL ENDOPEPTIDASE

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 LEU A 470
ALA A 534
ILE A 454
ALA A 500
ILE A 440
 None
 0.93A 4o2bD-3dduA:
3.3		 4o2bD-3dduA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkt MARITIMACIN

(Thermotoga
maritima) 		PF04454
(Linocin_M18) 		5 LEU A 266
ALA A 154
ILE A 175
ALA A 215
ILE A 206
 None
 0.91A 4o2bD-3dktA:
undetectable		 4o2bD-3dktA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 193
ALA A  86
ILE A 177
ALA A 354
ILE A   6
 None
 0.95A 4o2bD-3e60A:
undetectable		 4o2bD-3e60A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 LEU A1021
LEU A 964
THR A 946
ALA A 961
ILE A 926
 None
 0.99A 4o2bD-3eh1A:
3.0		 4o2bD-3eh1A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fww BIFUNCTIONAL PROTEIN
GLMU

(Yersinia pestis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 338
ALA A 336
ALA A 361
ALA A 342
ILE A 378
 None
 0.84A 4o2bD-3fwwA:
undetectable		 4o2bD-3fwwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fww BIFUNCTIONAL PROTEIN
GLMU

(Yersinia pestis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.96A 4o2bD-3fwwA:
undetectable		 4o2bD-3fwwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)

(Clostridium
acetobutylicum) 		PF13377
(Peripla_BP_3) 		5 CYH A 248
LEU A 246
ALA A 185
ALA A 232
ILE A 253
 None
 0.96A 4o2bD-3g85A:
4.0		 4o2bD-3g85A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmu AMINOTRANSFERASE,
CLASS III

(Ruegeria
pomeroyi) 		PF00202
(Aminotran_3) 		5 LEU A 357
ALA A 380
ILE A 382
ALA A 373
ILE A 425
 None
 0.90A 4o2bD-3hmuA:
undetectable		 4o2bD-3hmuA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		5 LEU A 450
ALA A 227
ILE A 254
ALA A 265
ILE A 463
 None
 0.96A 4o2bD-3j04A:
undetectable		 4o2bD-3j04A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens) 		PF01582
(TIR)
PF13855
(LRR_8) 		5 LEU A 410
LEU A 389
ILE A 421
ALA A 425
ILE A 402
 None
 0.98A 4o2bD-3j0aA:
undetectable		 4o2bD-3j0aA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv9 TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF03466
(LysR_substrate) 		5 LEU A 106
LEU A 113
LEU A  95
ILE A 293
ALA A 292
 None
 0.76A 4o2bD-3jv9A:
undetectable		 4o2bD-3jv9A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		5 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
 None
 0.79A 4o2bD-3k1jA:
undetectable		 4o2bD-3k1jA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvs C-PHYCOCYANIN BETA
CHAIN

(Galdieria
sulphuraria) 		PF00502
(Phycobilisome) 		5 LEU B 105
ALA B 167
ILE B  97
ALA B  96
ILE B  44
 None
 0.98A 4o2bD-3kvsB:
undetectable		 4o2bD-3kvsB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nur AMIDOHYDROLASE

(Staphylococcus
aureus) 		PF04909
(Amidohydro_2) 		5 LEU A 135
ALA A 143
ALA A 182
ILE A 189
ALA A 159
 None
 0.97A 4o2bD-3nurA:
undetectable		 4o2bD-3nurA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2s RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
SSU72

(Homo sapiens) 		PF04722
(Ssu72) 		5 ASN B  24
ALA B 152
ILE B 141
ALA B 148
ILE B 155
 None
 0.98A 4o2bD-3o2sB:
undetectable		 4o2bD-3o2sB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		5 ALA A  87
LEU A  83
ILE A 145
ALA A 120
ILE A 147
 None
 0.89A 4o2bD-3o75A:
2.5		 4o2bD-3o75A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica) 		PF13561
(adh_short_C2) 		6 ALA A  68
THR A 184
ALA A 133
ILE A 131
ALA A  52
ILE A 182
 None
NAD  A 300 ( 4.4A)
None
None
None
None
 1.29A 4o2bD-3r3sA:
6.8		 4o2bD-3r3sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE

(Bartonella
henselae) 		PF00701
(DHDPS) 		5 ALA A 293
LEU A 244
ALA A 260
LYS A 263
ILE A 257
 None
 0.95A 4o2bD-3si9A:
undetectable		 4o2bD-3si9A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twd BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep) 		5 LEU A 338
ALA A 336
ALA A 361
ALA A 342
ILE A 378
 None
 0.69A 4o2bD-3twdA:
undetectable		 4o2bD-3twdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twd BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep) 		5 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.84A 4o2bD-3twdA:
undetectable		 4o2bD-3twdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 LEU A 214
ALA A 233
ILE A 245
ALA A 244
ILE A 575
 None
 0.91A 4o2bD-3u1kA:
undetectable		 4o2bD-3u1kA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		5 LEU A 107
ALA A 249
ILE A 173
ALA A 172
ILE A 184
 None
 0.98A 4o2bD-3wrcA:
undetectable		 4o2bD-3wrcA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtc PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00106
(adh_short) 		5 LEU A  73
THR A  11
ALA A   9
ILE A   7
ILE A  33
 None
 0.98A 4o2bD-3wtcA:
7.2		 4o2bD-3wtcA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdj ENCA BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		5 CYH A  77
LEU A  81
LEU A 138
ILE A 127
ALA A 126
 None
 0.84A 4o2bD-3zdjA:
undetectable		 4o2bD-3zdjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bru ATP-DEPENDENT RNA
HELICASE DHH1

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 223
ALA A  80
ALA A 117
ILE A 119
ILE A 167
 None
 0.95A 4o2bD-4bruA:
undetectable		 4o2bD-4bruA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		5 LEU A  86
THR A 100
ALA A  98
ILE A  96
ILE A 145
 None
 0.89A 4o2bD-4c90A:
undetectable		 4o2bD-4c90A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5r A49

(Vaccinia virus) 		PF06489
(Orthopox_A49R) 		5 LEU A  65
LEU A 153
ASN A 108
ILE A 146
ILE A 142
 None
 0.97A 4o2bD-4d5rA:
undetectable		 4o2bD-4d5rA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00701
(DHDPS) 		5 ALA A  65
ALA A 162
ILE A 192
ALA A 219
ILE A 137
 None
 0.92A 4o2bD-4dppA:
3.1		 4o2bD-4dppA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3w ACID PHOSPHATASE

(Francisella
tularensis) 		PF00328
(His_Phos_2) 		5 ALA A  29
LEU A 170
THR A 182
ALA A 190
ILE A 209
 None
 0.96A 4o2bD-4e3wA:
undetectable		 4o2bD-4e3wA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e51 HISTIDINE--TRNA
LIGASE

(Burkholderia
thailandensis) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 LEU A 140
ALA A 308
LEU A 297
ILE A 100
ALA A  99
 None
 0.79A 4o2bD-4e51A:
undetectable		 4o2bD-4e51A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fho INTERNALIN C2

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		6 LEU A 103
ALA A  83
LEU A  53
ILE A  78
LYS A  58
ALA A  60
 None
 1.04A 4o2bD-4fhoA:
undetectable		 4o2bD-4fhoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmt CHPT PROTEIN

(Caulobacter
vibrioides) 		PF10090
(HPTransfase) 		5 LEU A 112
ALA A 101
ALA A 161
ALA A 146
ILE A 219
 None
 0.87A 4o2bD-4fmtA:
undetectable		 4o2bD-4fmtA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE

(Photorhabdus
laumondii) 		PF01494
(FAD_binding_3) 		5 LEU A 117
LEU A  54
ILE A 108
ALA A  69
ILE A  46
 None
 0.91A 4o2bD-4hb9A:
undetectable		 4o2bD-4hb9A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyk UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF12866
(DUF3823) 		5 LEU A 140
ALA A 216
ILE A 214
ALA A 231
ILE A 152
 None
 0.97A 4o2bD-4iykA:
undetectable		 4o2bD-4iykA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		5 LEU A  38
ALA A  71
LEU A  67
THR A  50
ALA A  37
 None
 0.90A 4o2bD-4kpnA:
6.2		 4o2bD-4kpnA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhq CAMELID NANOBODY

(Vicugna pacos) 		PF07686
(V-set) 		5 CYH B  22
LEU B   4
ALA B  24
ASN B  32
ILE B  51
 None
 0.86A 4o2bD-4lhqB:
undetectable		 4o2bD-4lhqB:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 LEU A 125
ALA A 121
ALA A 221
ILE A 224
ILE A 226
 None
 0.99A 4o2bD-4lixA:
undetectable		 4o2bD-4lixA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6s C-PHYCOCYANIN BETA
SUBUNIT

(Thermosynechococcus
vulcanus) 		PF00502
(Phycobilisome) 		5 LEU B 107
ALA B 169
ILE B  99
ALA B  98
ILE B  44
 None
 0.97A 4o2bD-4n6sB:
undetectable		 4o2bD-4n6sB:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf2 ORNITHINE
CARBAMOYLTRANSFERASE

(Bacillus
anthracis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A 173
ASN A 193
ILE A 211
ALA A 200
ILE A 213
 None
 0.95A 4o2bD-4nf2A:
undetectable		 4o2bD-4nf2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5h PHENYLACETALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 LEU A 180
ALA A 128
ILE A 187
ALA A 188
ILE A 216
 None
 0.97A 4o2bD-4o5hA:
undetectable		 4o2bD-4o5hA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3

(Populus
trichocarpa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 ALA A   4
ILE A  49
LYS A 222
ALA A 220
ILE A 183
 None
 0.99A 4o2bD-4pqiA:
undetectable		 4o2bD-4pqiA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpg PROTON:OLIGOPEPTIDE
SYMPORTER POT FAMILY

(Shewanella
oneidensis) 		PF00854
(PTR2) 		5 LEU A 160
LEU A  34
ALA A 181
ASN A 169
ALA A 323
 None
 0.89A 4o2bD-4tpgA:
undetectable		 4o2bD-4tpgA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		5 LEU A  95
ALA A 184
ILE A 182
ALA A  17
ILE A 210
 None
 0.80A 4o2bD-4twiA:
3.8		 4o2bD-4twiA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct) 		PF00805
(Pentapeptide) 		5 ALA A  75
LEU A  52
ILE A  40
ALA A  60
ILE A  26
 None
 0.90A 4o2bD-4yeiA:
undetectable		 4o2bD-4yeiA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		5 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
 None
 0.81A 4o2bD-4zpxA:
undetectable		 4o2bD-4zpxA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztk CELL DIVISION
PROTEIN
FTSI/PENICILLIN
BINDING PROTEIN 2

(Legionella
pneumophila) 		PF00905
(Transpeptidase) 		5 LEU A 447
THR A 569
ILE A 542
LYS A 403
ALA A 407
 None
NHE  A 901 (-3.6A)
None
None
None
 0.98A 4o2bD-4ztkA:
undetectable		 4o2bD-4ztkA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 LEU A  91
LEU A  98
LEU A 235
ILE A  82
ALA A 104
 None
 0.98A 4o2bD-5d6nA:
undetectable		 4o2bD-5d6nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgt BENZOYLFORMATE
DECARBOXYLASE

(Pseudomonas
putida) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 LEU A 373
LEU A 407
ALA A 441
ILE A  53
ALA A 437
ILE A 446
 None
 1.27A 4o2bD-5dgtA:
2.5		 4o2bD-5dgtA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1v POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		no annotation 5 LEU B  62
ALA B  94
ILE B  92
ALA B 114
ILE B  80
 None
 0.91A 4o2bD-5e1vB:
undetectable		 4o2bD-5e1vB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecx DEHYDROFOLATE
REDUCTASE TYPE I

(Klebsiella
pneumoniae) 		PF00186
(DHFR_1) 		6 LEU A   2
LEU A  86
THR A  46
ILE A  79
ALA A  82
ILE A 101
 None
None
NAP  A 201 (-3.2A)
NAP  A 201 (-4.2A)
None
NAP  A 201 (-4.1A)
 1.38A 4o2bD-5ecxA:
undetectable		 4o2bD-5ecxA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		6 LEU L 125
LEU L   4
ALA L 135
ASN L 158
ILE L  13
ALA L  15
 None
 1.31A 4o2bD-5fmgL:
undetectable		 4o2bD-5fmgL:
18.34