SIMILAR PATTERNS OF AMINO ACIDS FOR 4O1Z_B_MXMB807_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 MET A 113
VAL A 116
LEU A 117
ARG A 120
ALA A 527
LEU A 531
 None
None
None
SCL  A 700 (-3.9A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.92A 4o1zB-1ebvA:
62.4		 4o1zB-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 MET A 113
VAL A 116
LEU A 117
ARG A 120
ILE A 345
VAL A 349
LEU A 359
TRP A 387
PHE A 518
ALA A 527
 None
None
None
SCL  A 700 (-3.9A)
None
SCL  A 700 ( 4.6A)
None
None
None
SCL  A 700 (-2.9A)
 0.57A 4o1zB-1ebvA:
62.4		 4o1zB-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gll GLYCEROL KINASE

(Escherichia
coli) 		no annotation 5 MET Y 203
VAL Y 206
LEU Y 207
ILE Y 132
LEU Y 120
 None
 1.09A 4o1zB-1gllY:
0.0		 4o1zB-1gllY:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		5 LEU A 315
ILE A 243
VAL A 287
PHE A 344
ALA A 308
 None
 1.02A 4o1zB-1gqjA:
0.0		 4o1zB-1gqjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iov D-ALA:D-ALA LIGASE

(Escherichia
coli) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 LEU A 248
VAL A 111
LEU A 268
ALA A 107
LEU A 103
 None
 1.04A 4o1zB-1iovA:
0.0		 4o1zB-1iovA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		5 LEU A 308
ILE A 236
VAL A 280
PHE A 343
ALA A 301
 None
 1.02A 4o1zB-1mqqA:
0.9		 4o1zB-1mqqA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rmg RHAMNOGALACTURONASE
A

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		5 VAL A  53
ILE A  93
VAL A  66
LEU A  68
ALA A  39
 None
 1.10A 4o1zB-1rmgA:
undetectable		 4o1zB-1rmgA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		5 VAL A 339
LEU A 328
ILE A 402
VAL A 400
LEU A 410
 None
 1.02A 4o1zB-1sqjA:
0.0		 4o1zB-1sqjA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1

(Mus musculus) 		PF03036
(Perilipin) 		5 ILE A 218
VAL A 241
LEU A 215
ALA A 254
LEU A 250
 None
 1.08A 4o1zB-1sziA:
undetectable		 4o1zB-1sziA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3g X-LINKED
INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1

(Homo sapiens) 		PF01582
(TIR) 		5 ILE A 448
TRP A 552
PHE A 551
ALA A 430
LEU A 431
 None
 1.11A 4o1zB-1t3gA:
undetectable		 4o1zB-1t3gA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu7 HISTIDYL-TRNA
SYNTHETASE

(Thermoplasma
acidophilum) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 ILE A 317
VAL A 316
LEU A 320
ALA A 286
LEU A 288
 None
 1.05A 4o1zB-1wu7A:
0.0		 4o1zB-1wu7A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y13 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE

(Plasmodium
falciparum) 		PF01242
(PTPS) 		5 MET A 142
LEU A 147
ARG A 150
VAL A  16
LEU A  67
 None
 1.07A 4o1zB-1y13A:
undetectable		 4o1zB-1y13A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Thermotoga
maritima) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 ILE A 244
VAL A 240
LEU A 256
ALA A 267
SER A 269
 None
 1.01A 4o1zB-1zczA:
undetectable		 4o1zB-1zczA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zel HYPOTHETICAL PROTEIN
RV2827C

(Mycobacterium
tuberculosis) 		PF09407
(AbiEi_1)
PF13338
(AbiEi_4) 		5 VAL A 285
LEU A 284
LEU A 200
TRP A 146
ALA A 188
 None
 1.07A 4o1zB-1zelA:
undetectable		 4o1zB-1zelA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE

(Alcaligenaceae
bacterium FB188) 		PF00850
(Hist_deacetyl) 		5 MET A 245
VAL A 249
LEU A 250
VAL A 263
ALA A 175
 None
 1.08A 4o1zB-1zz3A:
undetectable		 4o1zB-1zz3A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anp LEUCYL
AMINOPEPTIDASE

(Vibrio
proteolyticus) 		PF04389
(Peptidase_M28) 		5 VAL A  10
LEU A  14
LEU A 208
ALA A 283
LEU A 280
 None
 1.02A 4o1zB-2anpA:
undetectable		 4o1zB-2anpA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7u CHARYBDIN

(Drimia maritima) 		PF00161
(RIP) 		5 LEU A  78
VAL A  12
LEU A  60
SER A  34
LEU A  35
 None
 1.11A 4o1zB-2b7uA:
undetectable		 4o1zB-2b7uA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 LEU A 164
ILE A 122
VAL A 124
LEU A 176
ALA A 157
 None
 1.03A 4o1zB-2de2A:
undetectable		 4o1zB-2de2A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djt UNNAMED PROTEIN
PRODUCT

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A  28
ILE A  94
VAL A  15
LEU A  92
ALA A  51
 None
 1.06A 4o1zB-2djtA:
undetectable		 4o1zB-2djtA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		5 VAL A 306
ILE A 235
VAL A 206
LEU A 255
ALA A 136
 None
 1.11A 4o1zB-2fqxA:
undetectable		 4o1zB-2fqxA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7g MONOOXYGENASE

(Agrobacterium
fabrum) 		PF00296
(Bac_luciferase) 		5 LEU A  47
ILE A  34
LEU A  31
ALA A  65
LEU A  64
 None
 1.11A 4o1zB-2i7gA:
undetectable		 4o1zB-2i7gA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		5 LEU A 316
ARG A 317
PHE A 383
ALA A 258
SER A 260
 None
 1.04A 4o1zB-2nxxA:
undetectable		 4o1zB-2nxxA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 VAL A 376
ILE A 479
LEU A 398
ALA A 390
LEU A 388
 None
 1.03A 4o1zB-2omvA:
undetectable		 4o1zB-2omvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3e DIAMINOPIMELATE
DECARBOXYLASE

(Aquifex
aeolicus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A 135
ILE A 198
VAL A 199
ALA A 149
LEU A 196
 None
 1.08A 4o1zB-2p3eA:
undetectable		 4o1zB-2p3eA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Aquifex
aeolicus) 		PF13561
(adh_short_C2) 		5 LEU A 146
ARG A 143
ILE A 156
LEU A 188
ALA A 140
 None
 1.08A 4o1zB-2p91A:
undetectable		 4o1zB-2p91A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE

(Ruegeria sp.
TM1040) 		PF07859
(Abhydrolase_3) 		5 LEU A 151
ILE A 130
VAL A  66
LEU A 132
ALA A 118
 None
 1.11A 4o1zB-2pblA:
undetectable		 4o1zB-2pblA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		5 LEU A 281
ILE A 330
VAL A 412
ALA A 255
LEU A 252
 None
 1.10A 4o1zB-2pqdA:
undetectable		 4o1zB-2pqdA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermotoga
maritima) 		PF00342
(PGI) 		5 MET A 118
VAL A 121
LEU A 122
LEU A  72
TRP A  62
 None
 1.01A 4o1zB-2q8nA:
undetectable		 4o1zB-2q8nA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2riu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Candida
albicans) 		PF00926
(DHBP_synthase) 		5 LEU A 198
ILE A  36
LEU A  21
ALA A 156
SER A 153
 None
 1.02A 4o1zB-2riuA:
undetectable		 4o1zB-2riuA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq6 ATP SYNTHASE EPSILON
CHAIN

(Thermosynechococcus
elongatus) 		PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N) 		5 MET A  49
LEU A  24
ILE A  76
VAL A  78
LEU A  44
 None
 1.11A 4o1zB-2rq6A:
undetectable		 4o1zB-2rq6A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl7 XPD

(Sulfurisphaera
tokodaii) 		PF06733
(DEAD_2)
PF13307
(Helicase_C_2) 		5 VAL A  43
LEU A  46
ILE A 341
VAL A 343
LEU A  31
 None
 1.11A 4o1zB-2vl7A:
undetectable		 4o1zB-2vl7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE

(Pseudomonas
fluorescens) 		PF00378
(ECH_1) 		5 MET C  41
VAL C  44
LEU C  45
ALA C  20
LEU C  57
 None
 0.70A 4o1zB-2vsuC:
undetectable		 4o1zB-2vsuC:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0i MALATE DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A  46
LEU A  44
VAL A  95
ALA A  37
SER A  36
 None
 1.08A 4o1zB-2x0iA:
0.5		 4o1zB-2x0iA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		5 MET A 532
VAL A 531
ILE A 422
VAL A 407
ALA A 459
 None
 1.09A 4o1zB-2x24A:
undetectable		 4o1zB-2x24A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 VAL A 605
LEU A 545
TRP A 589
ALA A 534
SER A 513
 None
 1.01A 4o1zB-2yr5A:
undetectable		 4o1zB-2yr5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1t IRON(II) TRANSPORT
PROTEIN B

(Thermotoga
maritima) 		PF02421
(FeoB_N) 		5 ILE A 152
VAL A 154
LEU A 150
ALA A 102
LEU A 100
 None
 1.10A 4o1zB-3a1tA:
undetectable		 4o1zB-3a1tA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1w IRON(II) TRANSPORT
PROTEIN B

(Thermotoga
maritima) 		PF02421
(FeoB_N) 		5 ILE A 152
VAL A 154
LEU A 150
ALA A 102
LEU A 100
 None
 1.02A 4o1zB-3a1wA:
undetectable		 4o1zB-3a1wA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anp TRANSCRIPTIONAL
REPRESSOR, TETR
FAMILY

(Thermus
thermophilus) 		no annotation 5 LEU C 186
ILE C 135
LEU C  89
ALA C 159
LEU C 158
 None
 1.09A 4o1zB-3anpC:
undetectable		 4o1zB-3anpC:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1

(Saccharomyces
cerevisiae) 		PF00128
(Alpha-amylase) 		6 VAL A 377
LEU A 374
PHE A 559
ALA A 539
SER A 527
LEU A 541
 None
 1.46A 4o1zB-3axiA:
undetectable		 4o1zB-3axiA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh6 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3

(Mus musculus) 		PF00025
(Arf) 		5 LEU A  37
ILE A  89
VAL A  91
LEU A  22
ALA A 160
 None
None
None
None
GNP  A   1 (-3.7A)
 1.01A 4o1zB-3bh6A:
undetectable		 4o1zB-3bh6A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnr TYPE IV FIMBRIAE
ASSEMBLY PROTEIN

(Xanthomonas
citri) 		PF07238
(PilZ) 		5 LEU A  54
ILE A  34
LEU A  13
ALA A  20
LEU A  21
 None
 1.04A 4o1zB-3cnrA:
undetectable		 4o1zB-3cnrA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsg TYPE IV FIMBRIAE
ASSEMBLY PROTEIN

(Xanthomonas
campestris) 		PF07238
(PilZ) 		5 LEU A  54
ILE A  34
LEU A  13
ALA A  20
LEU A  21
 None
 1.12A 4o1zB-3dsgA:
undetectable		 4o1zB-3dsgA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1h PUTATIVE
UNCHARACTERIZED
PROTEIN

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 MET A  45
VAL A  48
LEU A  49
VAL A 190
LEU A 194
 None
 1.04A 4o1zB-3e1hA:
undetectable		 4o1zB-3e1hA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 MET A  45
VAL A  48
LEU A  49
VAL A 190
LEU A 194
 None
 1.03A 4o1zB-3euoA:
undetectable		 4o1zB-3euoA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7o SERINE PROTEASE

(Purpureocillium
lilacinum) 		PF00082
(Peptidase_S8) 		5 MET A 151
VAL A 156
LEU A 158
ILE A  40
ALA A  37
 None
 1.09A 4o1zB-3f7oA:
undetectable		 4o1zB-3f7oA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fib FIBRINOGEN GAMMA
CHAIN RESIDUES

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		5 MET A 384
VAL A 248
LEU A 246
PHE A 295
ALA A 289
 None
 1.05A 4o1zB-3fibA:
undetectable		 4o1zB-3fibA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 MET A 253
VAL A 250
ILE A 116
PHE A 294
ALA A 217
 None
 1.06A 4o1zB-3gbdA:
undetectable		 4o1zB-3gbdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfv UNCHARACTERIZED ABC
TRANSPORTER
SOLUTE-BINDING
PROTEIN YCLQ

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		5 VAL A  80
ILE A 115
PHE A 143
ALA A  58
LEU A  94
 None
 1.09A 4o1zB-3gfvA:
undetectable		 4o1zB-3gfvA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghg FIBRINOGEN GAMMA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		6 MET C 384
VAL C 248
LEU C 246
LEU C 344
PHE C 295
ALA C 289
 MET  C 384 ( 0.0A)
VAL  C 248 ( 0.6A)
LEU  C 246 ( 0.6A)
LEU  C 344 ( 0.6A)
PHE  C 295 ( 1.3A)
ALA  C 289 ( 0.0A)
 1.50A 4o1zB-3ghgC:
undetectable		 4o1zB-3ghgC:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv9 TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF03466
(LysR_substrate) 		5 LEU A 124
ILE A 110
LEU A 113
PHE A 303
LEU A 106
 None
 1.05A 4o1zB-3jv9A:
undetectable		 4o1zB-3jv9A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n28 PHOSPHOSERINE
PHOSPHATASE

(Vibrio cholerae) 		PF00702
(Hydrolase) 		5 MET A 180
ILE A 199
VAL A 197
LEU A 112
LEU A 215
 None
 1.11A 4o1zB-3n28A:
undetectable		 4o1zB-3n28A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nns DNA BINDING RESPONSE
REGULATOR B

(Thermotoga
maritima) 		PF00072
(Response_reg) 		5 VAL A  18
LEU A  22
ILE A  75
VAL A  98
LEU A  77
 None
 1.09A 4o1zB-3nnsA:
undetectable		 4o1zB-3nnsA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 VAL A 797
LEU A 794
LEU A 806
PHE A 709
ALA A 678
 None
 0.93A 4o1zB-3pihA:
undetectable		 4o1zB-3pihA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmt 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
halodurans) 		PF00275
(EPSP_synthase) 		5 VAL A 272
LEU A 273
ILE A 322
ALA A 327
LEU A 326
 None
 1.10A 4o1zB-3rmtA:
undetectable		 4o1zB-3rmtA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whp PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		5 LEU A 229
VAL A 244
LEU A 221
ALA A 236
LEU A 259
 None
 1.12A 4o1zB-3whpA:
undetectable		 4o1zB-3whpA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 6 VAL A  64
LEU A  39
VAL A  51
LEU A  48
ALA A  31
LEU A  27
 None
 1.44A 4o1zB-3wvrA:
undetectable		 4o1zB-3wvrA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE

(Thermococcus
litoralis) 		PF04587
(ADP_PFK_GK) 		5 ILE A 135
LEU A 129
PHE A 223
ALA A 237
LEU A 236
 None
 1.07A 4o1zB-4b8sA:
0.9		 4o1zB-4b8sA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		5 VAL A 443
LEU A 376
ILE A 477
VAL A 550
LEU A 474
 None
 0.90A 4o1zB-4conA:
1.0		 4o1zB-4conA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3s IMINE REDUCTASE

(Nocardiopsis
halophila) 		PF03446
(NAD_binding_2) 		5 VAL A  81
ILE A  94
VAL A  68
LEU A  70
ALA A  61
 None
 1.06A 4o1zB-4d3sA:
undetectable		 4o1zB-4d3sA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnh UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF06187
(DUF993) 		5 MET A 379
VAL A 382
LEU A 383
SER A 352
LEU A 353
 None
 1.02A 4o1zB-4dnhA:
undetectable		 4o1zB-4dnhA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fha DIHYDRODIPICOLINATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00701
(DHDPS) 		5 LEU A  37
ILE A  16
VAL A 258
LEU A 262
ALA A 212
 None
 1.04A 4o1zB-4fhaA:
undetectable		 4o1zB-4fhaA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 LEU A  43
ILE A 207
VAL A 209
LEU A  28
ALA A 327
 None
None
None
None
GDP  A 401 (-3.2A)
 1.10A 4o1zB-4fidA:
undetectable		 4o1zB-4fidA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 LEU A 106
VAL A 313
LEU A 368
SER A 164
LEU A 163
 None
 1.02A 4o1zB-4grvA:
undetectable		 4o1zB-4grvA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Acidimicrobium
ferrooxidans) 		PF09481
(CRISPR_Cse1) 		6 VAL A  57
LEU A  60
ILE A  88
PHE A  19
SER A  28
LEU A  29
 None
 1.31A 4o1zB-4h3tA:
undetectable		 4o1zB-4h3tA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfk PUTATIVE CYTOPLASMIC
PROTEIN

(Enterobacter
cloacae) 		PF14113
(Tae4) 		5 MET A  50
VAL A  53
LEU A  54
LEU A 131
ALA A  10
 None
 1.11A 4o1zB-4hfkA:
undetectable		 4o1zB-4hfkA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 MET A 280
VAL A 277
ILE A 143
PHE A 321
ALA A 244
 None
 1.10A 4o1zB-4hozA:
undetectable		 4o1zB-4hozA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE

(Toxoplasma
gondii) 		PF00316
(FBPase) 		5 LEU A  31
LEU A 183
ALA A 153
SER A 154
LEU A 155
 None
 1.08A 4o1zB-4ir8A:
undetectable		 4o1zB-4ir8A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED

(Xanthomonas
oryzae) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU B 375
ILE B 285
LEU B 317
ALA B 392
LEU B 389
 None
 1.07A 4o1zB-4iyoB:
undetectable		 4o1zB-4iyoB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ltm NADH-DEPENDENT FMN
REDUCTASE

(EDTA-degrading
bacterium BNC1) 		PF03358
(FMN_red) 		5 VAL A  29
ARG A 172
VAL A 137
LEU A 106
LEU A 175
 None
 1.09A 4o1zB-4ltmA:
undetectable		 4o1zB-4ltmA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh1 L-IDITOL
2-DEHYDROGENASE

([Clostridium]
scindens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 178
VAL A 176
LEU A 245
ALA A 195
LEU A 191
 None
 1.07A 4o1zB-4oh1A:
undetectable		 4o1zB-4oh1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4olq ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Hyphomonas
neptunium) 		PF00378
(ECH_1) 		5 LEU A 116
ILE A   5
ALA A  26
SER A  28
LEU A  27
 None
 1.06A 4o1zB-4olqA:
undetectable		 4o1zB-4olqA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt RETINOID X RECEPTOR

(Pediculus
humanus) 		PF00104
(Hormone_recep) 		5 LEU U 303
ARG U 304
PHE U 370
ALA U 245
SER U 247
 None
 1.07A 4o1zB-4oztU:
undetectable		 4o1zB-4oztU:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p68 DIHYDROFOLATE
REDUCTASE

(Escherichia
coli) 		PF00186
(DHFR_1) 		5 VAL A  93
ILE A  61
VAL A  75
LEU A  62
ALA A  85
 None
None
None
NAP  A 202 (-3.9A)
None
 0.93A 4o1zB-4p68A:
undetectable		 4o1zB-4p68A:
13.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 MET A 114
VAL A 117
LEU A 118
ARG A 121
ILE A 346
VAL A 350
LEU A 360
TRP A 388
PHE A 519
ALA A 528
SER A 531
 None
BOG  A 604 (-3.9A)
None
BOG  A 604 ( 3.7A)
None
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
None
None
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
 0.77A 4o1zB-4ph9A:
58.8		 4o1zB-4ph9A:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		9 MET A 114
VAL A 117
LEU A 118
ARG A 121
TRP A 388
PHE A 519
ALA A 528
SER A 531
LEU A 532
 None
BOG  A 604 (-3.9A)
None
BOG  A 604 ( 3.7A)
None
None
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
 1.07A 4o1zB-4ph9A:
58.8		 4o1zB-4ph9A:
64.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00266
(Aminotran_5) 		5 LEU A 331
ILE A 378
VAL A 376
LEU A  42
LEU A 418
 None
 1.07A 4o1zB-4q76A:
undetectable		 4o1zB-4q76A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2

(Mycobacterium
tuberculosis) 		PF00574
(CLP_protease) 		5 MET A  93
LEU A  60
LEU A 115
ALA A  53
SER A  52
 None
 0.91A 4o1zB-4u0gA:
undetectable		 4o1zB-4u0gA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu4 HEMOGLOBIN

(Helogale
parvula) 		PF00042
(Globin) 		5 VAL B 137
LEU B  81
VAL B  11
LEU B  75
PHE B 122
 None
 1.11A 4o1zB-4yu4B:
undetectable		 4o1zB-4yu4B:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a87 METALLO-BETA-LACTAMA
SE VIM-5

(Klebsiella
pneumoniae) 		PF00753
(Lactamase_B) 		5 LEU A 172
ARG A 166
ILE A  83
VAL A  74
LEU A  81
 None
 1.01A 4o1zB-5a87A:
undetectable		 4o1zB-5a87A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF12897
(Aminotran_MocR) 		5 VAL A 325
LEU A 329
ILE A 391
VAL A 373
ALA A 406
 None
 0.96A 4o1zB-5c6uA:
undetectable		 4o1zB-5c6uA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2

(Mus musculus) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 VAL A 354
LEU A 358
VAL A 239
ALA A 300
SER A 304
 None
 0.95A 4o1zB-5cm9A:
undetectable		 4o1zB-5cm9A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 MET A 224
ILE A   6
VAL A 166
LEU A 188
PHE A 100
 None
 0.94A 4o1zB-5e7qA:
undetectable		 4o1zB-5e7qA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g10 HDAH

(Pseudomonas
aeruginosa) 		PF00850
(Hist_deacetyl) 		5 MET A 246
VAL A 250
LEU A 251
VAL A 264
ALA A 176
 None
 1.10A 4o1zB-5g10A:
undetectable		 4o1zB-5g10A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtj DUAL SPECIFICITY
PROTEIN PHOSPHATASE
26

(Homo sapiens) 		PF00782
(DSPc) 		5 LEU A 167
ILE A 137
VAL A 150
LEU A  69
ALA A 160
 None
 1.11A 4o1zB-5gtjA:
undetectable		 4o1zB-5gtjA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG

(Microbacterium
sp.) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		5 LEU A 181
VAL A 113
ALA A 139
SER A 140
LEU A 144
 None
 1.11A 4o1zB-5h1aA:
undetectable		 4o1zB-5h1aA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ha4 DIAMINOPIMELATE
EPIMERASE

(Acinetobacter
baumannii) 		PF01678
(DAP_epimerase) 		5 MET A  16
VAL A  18
ILE A  32
LEU A  35
ALA A  25
 None
 1.08A 4o1zB-5ha4A:
undetectable		 4o1zB-5ha4A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		5 VAL A 154
LEU A 152
ARG A 150
LEU A 125
ALA A 146
 None
 1.00A 4o1zB-5hxaA:
undetectable		 4o1zB-5hxaA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 MET A 113
VAL A 116
LEU A 117
ARG A 120
ILE A 345
VAL A 349
LEU A 359
TRP A 387
PHE A 518
ALA A 527
SER A 530
 None
None
None
ID8  A 601 ( 4.4A)
None
ID8  A 601 (-3.9A)
None
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.73A 4o1zB-5ikrA:
58.8		 4o1zB-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		8 MET A 113
VAL A 116
LEU A 117
ARG A 120
TRP A 387
PHE A 518
ALA A 527
LEU A 531
 None
None
None
ID8  A 601 ( 4.4A)
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.97A 4o1zB-5ikrA:
58.8		 4o1zB-5ikrA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izh RNA-DIRECTED RNA
POLYMERASE L

(Lassa
mammarenavirus) 		PF17296
(ArenaCapSnatch) 		5 LEU A 160
ARG A 161
LEU A  39
SER A  47
LEU A  46
 None
 0.90A 4o1zB-5izhA:
undetectable		 4o1zB-5izhA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6c PUTATIVE REDUCTASE

(Clostridioides
difficile) 		PF00881
(Nitroreductase) 		5 VAL A 142
LEU A 140
ARG A 137
ILE A 151
VAL A 121
 None
 1.10A 4o1zB-5j6cA:
undetectable		 4o1zB-5j6cA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		6 LEU A 946
ARG A 848
ILE A 833
PHE A 708
ALA A 846
LEU A 847
 None
None
None
PG4  A2005 (-3.7A)
None
None
 1.47A 4o1zB-5kf7A:
0.5		 4o1zB-5kf7A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		5 LEU B  95
ILE B 197
VAL B 209
ALA B 173
LEU B 168
 None
 1.11A 4o1zB-5l9wB:
undetectable		 4o1zB-5l9wB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 LEU A 673
ILE A 634
LEU A 631
SER A 710
LEU A 711
 None
 1.03A 4o1zB-5lmgA:
1.7		 4o1zB-5lmgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol9 TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 LEU A 112
ILE A 133
LEU A 134
ALA A  71
LEU A  74
 None
 1.12A 4o1zB-5ol9A:
undetectable		 4o1zB-5ol9A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvg ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Burkholderia
vietnamiensis) 		PF00982
(Glyco_transf_20) 		5 VAL A 147
LEU A 145
ARG A 143
LEU A 118
ALA A 139
 None
 1.05A 4o1zB-5tvgA:
undetectable		 4o1zB-5tvgA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhv ALKYLPURINE DNA
GLYCOSYLASE ALKC

(Pseudomonas
fluorescens) 		no annotation 5 LEU A  18
VAL A  64
LEU A  61
ALA A  34
LEU A  38
 None
 1.08A 4o1zB-5vhvA:
undetectable		 4o1zB-5vhvA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi9 -

(-) 		no annotation 5 LEU A 141
VAL A  96
PHE A 483
SER A 461
LEU A 462
 None
 1.10A 4o1zB-5wi9A:
undetectable		 4o1zB-5wi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjb CYSTATHIONINE
BETA-LYASE

(Legionella
pneumophila) 		no annotation 5 LEU A 364
ILE A 274
LEU A 306
ALA A 381
LEU A 378
 None
 0.89A 4o1zB-6cjbA:
undetectable		 4o1zB-6cjbA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fc3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Saccharomyces
cerevisiae) 		no annotation 5 VAL A 185
LEU A 186
VAL A 152
LEU A 165
PHE A  68
 None
 0.88A 4o1zB-6fc3A:
undetectable		 4o1zB-6fc3A:
12.26