SIMILAR PATTERNS OF AMINO ACIDS FOR 4O1Z_A_MXMA807_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE

(Gadus morhua) 		PF00171
(Aldedh) 		4 VAL A  17
LEU A  49
LEU A 103
PHE A 188
 None
 1.05A 4o1zA-1a4sA:
0.0		 4o1zA-1a4sA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6g MYOGLOBIN

(Physeter
catodon) 		PF00042
(Globin) 		4 VAL A 114
LEU A 115
ARG A 118
LEU A  69
 None
 0.98A 4o1zA-1a6gA:
undetectable		 4o1zA-1a6gA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8u PROTEIN (MALATE
DEHYDROGENASE)

(Aquaspirillum
arcticum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A   8
LEU A  39
LEU A  21
PHE A 112
 None
 1.08A 4o1zA-1b8uA:
0.0		 4o1zA-1b8uA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		4 VAL A  93
LEU A  97
ARG A  96
LEU A  52
 None
 0.96A 4o1zA-1cg4A:
undetectable		 4o1zA-1cg4A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)

(Burkholderia
gladioli) 		PF00144
(Beta-lactamase) 		4 LEU A 131
LEU A 163
PHE A 219
MET A 277
 None
 1.07A 4o1zA-1ci9A:
0.0		 4o1zA-1ci9A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1civ NADP-MALATE
DEHYDROGENASE

(Flaveria
bidentis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A  45
LEU A  76
LEU A  58
PHE A 147
 None
 1.10A 4o1zA-1civA:
0.0		 4o1zA-1civA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 VAL A 116
LEU A 117
ARG A 120
LEU A 359
PHE A 518
MET A 522
 None
None
SCL  A 700 (-3.9A)
None
None
None
 0.49A 4o1zA-1ebvA:
62.2		 4o1zA-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 VAL A 335
LEU A 354
PHE A 180
MET A 156
 None
 1.13A 4o1zA-1g0dA:
0.0		 4o1zA-1g0dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
mutans) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 VAL A 227
LEU A 228
ARG A 230
LEU A 252
 None
 0.95A 4o1zA-1i74A:
0.0		 4o1zA-1i74A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
gordonii) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 VAL A 229
LEU A 230
ARG A 232
LEU A 254
 None
 0.70A 4o1zA-1k20A:
undetectable		 4o1zA-1k20A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldn L-LACTATE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A 215
LEU A 214
ARG A 212
LEU A 174
 None
 1.10A 4o1zA-1ldnA:
undetectable		 4o1zA-1ldnA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nuq FKSG76

(Homo sapiens) 		PF01467
(CTP_transf_like) 		4 VAL A  41
LEU A  33
ARG A  30
LEU A 133
 None
 1.00A 4o1zA-1nuqA:
undetectable		 4o1zA-1nuqA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4a PUR OPERON REPRESSOR

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF09182
(PuR_N) 		4 VAL A 114
LEU A 115
LEU A 232
PHE A 273
 None
 1.05A 4o1zA-1p4aA:
undetectable		 4o1zA-1p4aA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Pseudomonas
putida) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 VAL A 243
LEU A 242
LEU A 180
PHE A  19
 None
 0.99A 4o1zA-1re5A:
undetectable		 4o1zA-1re5A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5i C_TERMINAL DOMAIN OF
A PROBABLE
ATP-DEPENDENT RNA
HELICASE

(Homo sapiens) 		PF00271
(Helicase_C) 		4 VAL A 291
LEU A 341
LEU A 346
PHE A 381
 None
 0.97A 4o1zA-1t5iA:
undetectable		 4o1zA-1t5iA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		4 VAL A 282
LEU A 283
LEU A 234
PHE A 219
 None
 0.95A 4o1zA-1ua4A:
undetectable		 4o1zA-1ua4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens) 		PF00079
(Serpin) 		4 LEU I 362
LEU I 146
PHE I 108
MET I 103
 None
 1.05A 4o1zA-2b4xI:
undetectable		 4o1zA-2b4xI:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A

(Starkeya
novella) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 VAL A 152
LEU A 172
LEU A 136
PHE A  70
 None
 1.10A 4o1zA-2ca4A:
undetectable		 4o1zA-2ca4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9o DNAJ (HSP40)
HOMOLOG, SUBFAMILY
C, MEMBER 17

(Homo sapiens) 		PF00076
(RRM_1) 		4 VAL A 193
LEU A 194
ARG A 196
LEU A 237
 None
 0.96A 4o1zA-2d9oA:
undetectable		 4o1zA-2d9oA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2diw PUTATIVE RNA-BINDING
PROTEIN 16

(Homo sapiens) 		PF04818
(CTD_bind) 		4 VAL A 122
LEU A 123
LEU A 108
PHE A  16
 None
 0.92A 4o1zA-2diwA:
undetectable		 4o1zA-2diwA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN

(Aequorea
victoria;
Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin)
PF01353
(GFP) 		4 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
PIA  A  66 ( 4.9A)
 0.97A 4o1zA-2jadA:
undetectable		 4o1zA-2jadA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kt0 HOMEOBOX PROTEIN
NANOG

(Homo sapiens) 		PF00046
(Homeobox) 		4 VAL A  36
LEU A  37
ARG A  40
LEU A  59
 None
 0.82A 4o1zA-2kt0A:
undetectable		 4o1zA-2kt0A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 VAL A  93
LEU A  91
LEU A 187
PHE A  63
 None
 1.01A 4o1zA-2rjtA:
undetectable		 4o1zA-2rjtA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		4 VAL A 414
LEU A 413
LEU A 281
PHE A 300
 None
None
EDO  A1481 (-4.0A)
None
 1.11A 4o1zA-2vg8A:
undetectable		 4o1zA-2vg8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyo POLYSACCHARIDE
DEACETYLASE
DOMAIN-CONTAINING
PROTEIN ECU11_0510

(Encephalitozoon
cuniculi) 		PF01522
(Polysacc_deac_1) 		4 VAL A  53
LEU A  51
LEU A 195
PHE A  59
 None
 1.12A 4o1zA-2vyoA:
undetectable		 4o1zA-2vyoA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Homo sapiens) 		PF04869
(Uso1_p115_head) 		4 VAL A 509
LEU A 513
PHE A 613
MET A 496
 None
 1.07A 4o1zA-2w3cA:
undetectable		 4o1zA-2w3cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN

(Aequorea
victoria;
Mus musculus) 		PF00240
(ubiquitin)
PF01353
(GFP) 		4 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CR2  A  66 ( 4.3A)
 0.94A 4o1zA-3ai5A:
undetectable		 4o1zA-3ai5A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ako VENUS

(Plant
transformation
vector
pSITEII-4C1) 		PF01353
(GFP) 		4 VAL A  55
LEU A  53
LEU A 125
PHE B 165
 None
None
None
CR2  A  66 ( 4.5A)
 0.94A 4o1zA-3akoA:
undetectable		 4o1zA-3akoA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9j XANTHINE OXIDASE

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 VAL B 330
LEU B 334
LEU B 348
PHE B 390
 None
 0.93A 4o1zA-3b9jB:
undetectable		 4o1zA-3b9jB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		4 VAL A 364
LEU A 365
LEU A 466
PHE A 473
 None
 0.97A 4o1zA-3c6gA:
undetectable		 4o1zA-3c6gA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crn RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN, CHEY-LIKE

(Methanospirillum
hungatei) 		PF00072
(Response_reg) 		4 VAL A   7
LEU A   5
LEU A  38
PHE A  90
 None
 1.02A 4o1zA-3crnA:
undetectable		 4o1zA-3crnA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5t MALATE DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A   8
LEU A  39
LEU A  21
PHE A 110
 None
 1.07A 4o1zA-3d5tA:
undetectable		 4o1zA-3d5tA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dli METHYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF13489
(Methyltransf_23) 		4 VAL A 352
LEU A 355
LEU A 364
PHE A 280
 None
 0.87A 4o1zA-3dliA:
undetectable		 4o1zA-3dliA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evp GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		4 VAL A 213
LEU A 211
LEU A 283
PHE A  78
 None
None
None
CRO  A 224 ( 4.4A)
 0.95A 4o1zA-3evpA:
undetectable		 4o1zA-3evpA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 VAL A 213
LEU A 211
LEU A 283
PHE A  78
 None
None
None
CRO  A 224 ( 4.5A)
 0.93A 4o1zA-3evrA:
undetectable		 4o1zA-3evrA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq2 GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Bos taurus) 		PF04869
(Uso1_p115_head) 		4 VAL A 509
LEU A 513
PHE A 613
MET A 496
 None
 1.11A 4o1zA-3gq2A:
1.4		 4o1zA-3gq2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6p PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		4 VAL A 426
LEU A 423
LEU A 322
PHE A 447
 NA  A 601 (-4.6A)
None
None
None
 1.13A 4o1zA-3o6pA:
undetectable		 4o1zA-3o6pA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 VAL A 329
LEU A 327
LEU A 399
PHE A 194
 None
None
None
C12  A 340 ( 4.7A)
 0.95A 4o1zA-3osqA:
undetectable		 4o1zA-3osqA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		4 VAL A 467
LEU A 465
LEU A 537
PHE A 332
 None
None
None
C12  A 478 ( 4.5A)
 0.92A 4o1zA-3osrA:
undetectable		 4o1zA-3osrA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 VAL A 797
LEU A 794
LEU A 806
PHE A 709
 None
 0.86A 4o1zA-3pihA:
undetectable		 4o1zA-3pihA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		4 VAL A 461
ARG A 420
LEU A 430
PHE A   7
 None
 1.10A 4o1zA-3pt1A:
undetectable		 4o1zA-3pt1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qj4 RENALASE

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 VAL A   4
LEU A  28
LEU A 338
MET A  11
 None
 1.10A 4o1zA-3qj4A:
undetectable		 4o1zA-3qj4A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		4 VAL A 520
LEU A 524
LEU A 619
PHE A 406
 None
 1.12A 4o1zA-3thcA:
undetectable		 4o1zA-3thcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 VAL A 659
LEU A 707
LEU A 671
PHE A 490
 None
 0.88A 4o1zA-3wdjA:
undetectable		 4o1zA-3wdjA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		4 VAL A 834
LEU A 831
LEU A 843
PHE A 746
 None
 1.01A 4o1zA-3zqjA:
undetectable		 4o1zA-3zqjA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PDX2 PROTEIN

(Plasmodium
falciparum) 		PF01174
(SNO) 		4 VAL G  57
LEU G  11
LEU G  72
PHE G 209
 None
 1.12A 4o1zA-4adsG:
undetectable		 4o1zA-4adsG:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		4 VAL A1055
LEU A1053
LEU A1125
PHE A1165
 None
None
None
CR2  A1065 ( 4.2A)
 0.84A 4o1zA-4anjA:
undetectable		 4o1zA-4anjA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04054
(Not1) 		4 VAL A1601
LEU A1600
LEU A1612
PHE A1726
 None
 1.07A 4o1zA-4by6A:
undetectable		 4o1zA-4by6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3

(Homo sapiens) 		PF01825
(GPS)
PF02793
(HRM)
PF16489
(GAIN) 		4 VAL A 739
LEU A 803
LEU A 762
PHE A 646
 None
 1.12A 4o1zA-4dloA:
0.6		 4o1zA-4dloA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola) 		PF13354
(Beta-lactamase2) 		4 LEU A  90
LEU A 138
PHE A 211
MET A 208
 None
 0.84A 4o1zA-4ev4A:
undetectable		 4o1zA-4ev4A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 VAL A 593
LEU A 597
LEU A 565
PHE A 504
 None
 1.03A 4o1zA-4fddA:
1.8		 4o1zA-4fddA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1i MALATE DEHYDROGENASE

(Leishmania
major) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A   6
LEU A  37
LEU A  19
PHE A 108
 None
 1.04A 4o1zA-4i1iA:
undetectable		 4o1zA-4i1iA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 4 VAL A 296
LEU A 300
LEU A 336
PHE A 348
 None
None
PGE  A 502 (-4.7A)
EGR  A 501 ( 4.7A)
 1.09A 4o1zA-4j0kA:
undetectable		 4o1zA-4j0kA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7m PROTEIN DOM3Z

(Mus musculus) 		PF08652
(RAI1) 		4 VAL A 361
LEU A  29
LEU A 138
PHE A 373
 None
 0.77A 4o1zA-4j7mA:
undetectable		 4o1zA-4j7mA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrb GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Blattella
germanica) 		PF01353
(GFP)
PF06757
(Ins_allergen_rp) 		4 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CR2  A  66 ( 4.4A)
 1.01A 4o1zA-4jrbA:
undetectable		 4o1zA-4jrbA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k08 METHYL-ACCEPTING
CHEMOTAXIS SENSORY
TRANSDUCER

(Anaeromyxobacter
dehalogenans) 		PF17200
(sCache_2) 		4 VAL A  59
LEU A  58
LEU A  81
PHE A 130
 None
None
None
ACT  A 201 ( 4.8A)
 0.98A 4o1zA-4k08A:
undetectable		 4o1zA-4k08A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		4 VAL A 125
LEU A 126
LEU A 102
PHE A  23
 None
 0.92A 4o1zA-4kwgA:
undetectable		 4o1zA-4kwgA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,

(Aequorea
victoria;
Eimeria
acervulina) 		PF00046
(Homeobox)
PF01353
(GFP) 		4 VAL A 108
LEU A 106
LEU A 178
PHE A 218
 None
None
None
CR2  A 118 ( 4.9A)
 0.99A 4o1zA-4ndkA:
undetectable		 4o1zA-4ndkA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ok7 ENDOLYSIN

(Salmonella
virus SPN1S) 		PF00182
(Glyco_hydro_19) 		4 VAL A 144
LEU A 153
PHE A  42
MET A  28
 None
 1.08A 4o1zA-4ok7A:
undetectable		 4o1zA-4ok7A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		4 VAL A 842
LEU A 840
LEU A 912
PHE A 952
 None
None
None
CRO  A 853 ( 4.6A)
 0.88A 4o1zA-4p7hA:
undetectable		 4o1zA-4p7hA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pa1 INTEGRASE

(Feline
immunodeficiency
virus) 		PF00665
(rve) 		4 VAL A 103
LEU A 104
LEU A 132
MET A  60
 None
 0.97A 4o1zA-4pa1A:
undetectable		 4o1zA-4pa1A:
15.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 VAL A 117
LEU A 118
ARG A 121
LEU A 360
MET A 523
 BOG  A 604 (-3.9A)
None
BOG  A 604 ( 3.7A)
IBP  A 601 ( 4.7A)
None
 0.64A 4o1zA-4ph9A:
58.8		 4o1zA-4ph9A:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 VAL A 117
LEU A 118
LEU A 360
PHE A 519
MET A 523
 BOG  A 604 (-3.9A)
None
IBP  A 601 ( 4.7A)
None
None
 0.77A 4o1zA-4ph9A:
58.8		 4o1zA-4ph9A:
64.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 VAL A 455
LEU A  73
LEU A 772
MET A 194
 None
 1.06A 4o1zA-4q73A:
undetectable		 4o1zA-4q73A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qei GLYCINE--TRNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 LEU A 252
LEU A 135
PHE A 292
MET A 294
 None
None
AMP  A 701 (-3.6A)
AMP  A 701 (-3.2A)
 1.06A 4o1zA-4qeiA:
undetectable		 4o1zA-4qeiA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpa PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 VAL A 227
LEU A 228
ARG A 230
LEU A 252
 None
 0.93A 4o1zA-4rpaA:
undetectable		 4o1zA-4rpaA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rus FISH-EGG LECTIN

(Cyprinus carpio) 		PF06462
(Hyd_WA) 		4 LEU A  55
LEU A  78
PHE A 159
MET A 145
 None
1PE  A 305 (-4.4A)
None
None
 1.10A 4o1zA-4rusA:
undetectable		 4o1zA-4rusA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvo MALATE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A   9
LEU A  40
LEU A  22
PHE A 111
 None
 0.97A 4o1zA-4tvoA:
undetectable		 4o1zA-4tvoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uul L-LACTATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A   7
LEU A  37
LEU A  20
PHE A 108
 None
 1.04A 4o1zA-4uulA:
undetectable		 4o1zA-4uulA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uup MALATE DEHYDROGENASE

(synthetic
construct) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A   7
LEU A  37
LEU A  20
PHE A 108
 None
 0.91A 4o1zA-4uupA:
undetectable		 4o1zA-4uupA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Plasmodium
falciparum) 		PF01353
(GFP)
PF02861
(Clp_N) 		4 VAL A 204
LEU A 202
LEU A 274
PHE A 314
 None
None
None
CRO  A 215 ( 4.9A)
 1.00A 4o1zA-4xbiA:
1.3		 4o1zA-4xbiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgy GREEN FLUORESCENT
PROTEIN, MAB LCDR3,
GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Vibrio
parahaemolyticus;
synthetic
construct) 		PF01353
(GFP) 		4 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CRO  A  66 ( 4.0A)
 1.00A 4o1zA-4xgyA:
undetectable		 4o1zA-4xgyA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu4 HEMOGLOBIN

(Helogale
parvula) 		PF00042
(Globin) 		4 VAL B 137
LEU B  81
LEU B  75
PHE B 122
 None
 1.12A 4o1zA-4yu4B:
undetectable		 4o1zA-4yu4B:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0v 2',5'-PHOSPHODIESTER
ASE 12

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 VAL A 428
LEU A 429
LEU A 414
PHE A 493
 None
None
GOL  A 707 ( 4.0A)
None
 1.06A 4o1zA-4z0vA:
undetectable		 4o1zA-4z0vA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1

(Aequorea
victoria;
Homo sapiens) 		PF01353
(GFP) 		4 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CR2  A  66 ( 4.1A)
 0.93A 4o1zA-4z4mA:
undetectable		 4o1zA-4z4mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zf4 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		4 VAL A   5
LEU A   3
LEU A  75
PHE A 115
 None
None
None
4NT  A  15 ( 4.2A)
 0.90A 4o1zA-4zf4A:
undetectable		 4o1zA-4zf4A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ch6 FRIGIDA

(Vitis vinifera) 		PF07899
(Frigida) 		4 VAL A 144
LEU A 140
LEU A 126
PHE A 244
 None
 1.10A 4o1zA-5ch6A:
undetectable		 4o1zA-5ch6A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 VAL B 531
LEU B 530
LEU B 465
PHE B 508
 None
 1.08A 4o1zA-5do8B:
undetectable		 4o1zA-5do8B:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewu MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF02514
(CobN-Mg_chel) 		4 VAL A1084
LEU A1030
LEU A1045
MET A1107
 None
 1.01A 4o1zA-5ewuA:
undetectable		 4o1zA-5ewuA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex8 CYTOCHROME P450

(Streptomyces
toyocaensis) 		PF00067
(p450) 		4 VAL A 249
LEU A 366
LEU A 387
MET A 273
 None
None
None
HEM  A 401 ( 4.9A)
 0.94A 4o1zA-5ex8A:
undetectable		 4o1zA-5ex8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgm ECF RNA POLYMERASE
SIGMA FACTOR SIGR

(Streptomyces
coelicolor) 		PF08281
(Sigma70_r4_2) 		4 VAL A 187
LEU A 191
ARG A 190
LEU A 165
 None
 0.88A 4o1zA-5fgmA:
undetectable		 4o1zA-5fgmA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D

(Aequorea
victoria;
Streptococcus
pyogenes) 		PF01353
(GFP)
PF13930
(Endonuclea_NS_2) 		4 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CR2  A  66 (-4.8A)
 0.95A 4o1zA-5fguA:
undetectable		 4o1zA-5fguA:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 VAL A 116
LEU A 117
ARG A 120
LEU A 359
PHE A 518
MET A 522
 None
None
ID8  A 601 ( 4.4A)
None
None
ID8  A 601 (-4.2A)
 0.79A 4o1zA-5ikrA:
58.8		 4o1zA-5ikrA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3n GREEN FLUORESCENT
PROTEIN,HSDR

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF12008
(EcoR124_C) 		4 VAL A  61
LEU A  59
LEU A 131
PHE A 171
 None
None
None
GYS  A  72 ( 4.5A)
 0.94A 4o1zA-5j3nA:
undetectable		 4o1zA-5j3nA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF12436
(USP7_ICP0_bdg) 		4 VAL A 401
LEU A 323
LEU A 528
PHE A 480
 None
 1.04A 4o1zA-5j7tA:
undetectable		 4o1zA-5j7tA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		4 VAL A 582
LEU A 580
ARG A 577
PHE A 534
 None
 0.96A 4o1zA-5jjhA:
undetectable		 4o1zA-5jjhA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF14533
(USP7_C2) 		4 VAL A 401
LEU A 323
LEU A 528
PHE A 480
 None
 1.00A 4o1zA-5jtvA:
undetectable		 4o1zA-5jtvA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens) 		PF04858
(TH1)
no annotation 		4 LEU A  61
LEU B 283
PHE B 227
MET B 230
 None
 0.96A 4o1zA-5l3xA:
undetectable		 4o1zA-5l3xA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, 18 KDA
SUBUNIT
MITOCHONDRIAL
COMPLEX I, B14
SUBUNIT

(Ovis aries) 		no annotation 4 VAL g  77
LEU g  80
ARG g  76
LEU c  22
 None
 1.11A 4o1zA-5lnkg:
undetectable		 4o1zA-5lnkg:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0o TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE

(Jeotgalicoccus
sp. ATCC 8456) 		PF00067
(p450) 		4 VAL A  16
LEU A  17
LEU A  41
PHE A  58
 None
 0.83A 4o1zA-5m0oA:
0.4		 4o1zA-5m0oA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mse GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		no annotation 4 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CRO  A  66 ( 4.4A)
 0.91A 4o1zA-5mseA:
undetectable		 4o1zA-5mseA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nge UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		no annotation 4 VAL A 401
LEU A 323
LEU A 528
PHE A 480
 None
 0.99A 4o1zA-5ngeA:
undetectable		 4o1zA-5ngeA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0h 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		4 LEU f 231
LEU f 255
PHE f 324
MET f 365
 None
 1.10A 4o1zA-5t0hf:
0.7		 4o1zA-5t0hf:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 VAL A 483
LEU A 482
LEU A 461
PHE A 419
 None
 1.01A 4o1zA-5t88A:
undetectable		 4o1zA-5t88A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujd SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNI

(Staphylococcus
pseudintermedius) 		no annotation 4 VAL A 214
LEU A 212
LEU A  10
MET A  64
 None
 1.06A 4o1zA-5ujdA:
undetectable		 4o1zA-5ujdA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme)
PF02793
(HRM) 		4 VAL A 396
LEU A 395
LEU A 358
MET A 231
 None
 1.03A 4o1zA-5xezA:
undetectable		 4o1zA-5xezA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv5 CONSERVED PROTEIN

(Methanosarcina
mazei) 		no annotation 4 VAL A 155
LEU A 153
LEU A 138
PHE A 197
 None
 1.05A 4o1zA-5xv5A:
undetectable		 4o1zA-5xv5A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7t GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria) 		no annotation 4 VAL A  85
LEU A  83
LEU A 155
PHE A 195
 None
None
None
GYS  A  96 ( 4.6A)
 0.90A 4o1zA-6b7tA:
undetectable		 4o1zA-6b7tA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bme TRUNCATED HEMOGLOBIN
4

(Chlamydomonas
reinhardtii) 		no annotation 5 VAL A 122
LEU A 125
LEU A 142
PHE A  65
MET A  56
 None
None
HEM  A 201 (-4.9A)
HEM  A 201 (-4.3A)
None
 1.50A 4o1zA-6bmeA:
undetectable		 4o1zA-6bmeA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fc3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A 185
LEU A 186
LEU A 165
PHE A  68
 None
 0.80A 4o1zA-6fc3A:
undetectable		 4o1zA-6fc3A:
12.26