SIMILAR PATTERNS OF AMINO ACIDS FOR 4O1Z_A_MXMA807_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)


(Escherichia
coli)
PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C)
6 VAL A 147
LEU A 150
GLY A 183
ALA A 182
LEU A 181
LEU A 131
None
1.39A 4o1zA-1b0aA:
0.0
4o1zA-1b0aA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)


(Pyrococcus
furiosus)
PF01314
(AFOR_C)
PF02730
(AFOR_N)
6 MET A 241
ILE A 269
VAL A 325
LEU A 328
GLY A 343
LEU A 253
None
1.04A 4o1zA-1b25A:
0.0
4o1zA-1b25A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 VAL A 103
ILE A  37
GLY A  21
ALA A  17
LEU A  48
None
0.97A 4o1zA-1ebdA:
0.0
4o1zA-1ebdA:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE


(Ovis aries)
PF00008
(EGF)
PF03098
(An_peroxidase)
7 ILE A 345
VAL A 349
LEU A 352
TRP A 387
GLY A 526
ALA A 527
LEU A 117
None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
None
1.29A 4o1zA-1ebvA:
62.2
4o1zA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE


(Ovis aries)
PF00008
(EGF)
PF03098
(An_peroxidase)
10 MET A 113
ILE A 345
VAL A 349
LEU A 352
TRP A 387
ILE A 523
GLY A 526
ALA A 527
LEU A 534
LEU A 535
None
None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 ( 3.3A)
None
0.56A 4o1zA-1ebvA:
62.2
4o1zA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE


(Ovis aries)
PF00008
(EGF)
PF03098
(An_peroxidase)
7 MET A 113
ILE A 523
GLY A 526
ALA A 527
LEU A 531
LEU A 534
LEU A 535
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
OAS  A 530 ( 3.3A)
None
1.07A 4o1zA-1ebvA:
62.2
4o1zA-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE


(Zymomonas
mobilis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 GLY A 207
ALA A 206
SER A 109
LEU A 110
LEU A 106
None
None
None
None
NAD  A 500 (-3.9A)
0.92A 4o1zA-1evjA:
0.0
4o1zA-1evjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius)
PF07859
(Abhydrolase_3)
5 ILE A 182
ILE A   7
GLY A 293
ALA A 294
LEU A 298
None
0.84A 4o1zA-1evqA:
0.0
4o1zA-1evqA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ILE A  28
VAL A   5
GLY A  11
LEU A  19
LEU A  20
None
None
FAD  A 448 (-3.7A)
None
None
0.97A 4o1zA-1f8wA:
0.0
4o1zA-1f8wA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE


(Zymomonas
mobilis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 GLY A 259
ALA A 258
SER A 161
LEU A 162
LEU A 158
None
None
None
None
NDP  A 500 (-4.1A)
0.92A 4o1zA-1h6dA:
0.0
4o1zA-1h6dA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7z ADENOVIRUS FIBRE
PROTEIN


(Human
mastadenovirus
B)
PF00541
(Adeno_knob)
6 MET A 230
ILE A 203
GLY A 136
LEU A 158
LEU A 210
LEU A 195
None
1.40A 4o1zA-1h7zA:
0.0
4o1zA-1h7zA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E


(Trichoderma
reesei)
PF01532
(Glyco_hydro_47)
5 ILE A  66
GLY A 107
SER A 111
LEU A 115
LEU A 116
None
0.91A 4o1zA-1hcuA:
0.0
4o1zA-1hcuA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icp 12-OXOPHYTODIENOATE
REDUCTASE 1


(Solanum
lycopersicum)
PF00724
(Oxidored_FMN)
5 LEU A 326
GLY A  23
ALA A 271
LEU A 270
LEU A 265
None
0.93A 4o1zA-1icpA:
undetectable
4o1zA-1icpA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j31 HYPOTHETICAL PROTEIN
PH0642


(Pyrococcus
horikoshii)
PF00795
(CN_hydrolase)
6 ILE A   7
VAL A  38
LEU A  37
GLY A 103
ALA A  76
LEU A  75
None
1.34A 4o1zA-1j31A:
undetectable
4o1zA-1j31A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9l STATIONARY PHASE
SURVIVAL PROTEIN


(Thermotoga
maritima)
PF01975
(SurE)
5 ILE A 226
VAL A 224
GLY A 138
ALA A 139
LEU A 143
None
0.85A 4o1zA-1j9lA:
undetectable
4o1zA-1j9lA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE


(Homo sapiens)
PF00135
(COesterase)
5 GLY A 197
ALA A 198
SER A 201
LEU A 202
LEU A 205
None
0.71A 4o1zA-1jmyA:
undetectable
4o1zA-1jmyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1


(Hordeum vulgare)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
5 ILE A 342
VAL A 346
ILE A  88
GLY A  51
LEU A 328
None
0.97A 4o1zA-1lq2A:
undetectable
4o1zA-1lq2A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE


(Homo sapiens)
PF02574
(S-methyl_trans)
6 ILE A  13
GLY A 209
ALA A 210
SER A 211
LEU A  14
LEU A  17
None
1.24A 4o1zA-1lt8A:
undetectable
4o1zA-1lt8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE


(Homo sapiens)
PF02574
(S-methyl_trans)
6 MET A 245
ILE A  13
GLY A 209
ALA A 210
LEU A  14
LEU A  17
None
1.41A 4o1zA-1lt8A:
undetectable
4o1zA-1lt8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8b RIBOSE 5-PHOSPHATE
ISOMERASE


(Escherichia
coli)
PF06026
(Rib_5-P_isom_A)
5 ILE A 189
VAL A 192
GLY A 196
LEU A 147
LEU A 150
None
0.95A 4o1zA-1o8bA:
undetectable
4o1zA-1o8bA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og6 HYPOTHETICAL
OXIDOREDUCTASE YDHF


(Escherichia
coli)
PF00248
(Aldo_ket_red)
5 ILE A  80
ALA A 110
SER A 113
LEU A 114
LEU A 117
None
0.88A 4o1zA-1og6A:
undetectable
4o1zA-1og6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum)
PF01229
(Glyco_hydro_39)
5 ILE A  82
ILE A  36
ALA A  30
LEU A  27
LEU A  56
None
0.89A 4o1zA-1px8A:
undetectable
4o1zA-1px8A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
6 ILE A 200
VAL A 177
LEU A 178
ILE A 369
LEU A 170
LEU A 260
None
1.23A 4o1zA-1s9iA:
undetectable
4o1zA-1s9iA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))


(Thermus
thermophilus)
PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N)
5 ILE A 387
ALA A 302
LEU A 306
LEU A 309
LEU A 311
None
0.96A 4o1zA-1serA:
undetectable
4o1zA-1serA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sh8 HYPOTHETICAL PROTEIN
PA5026


(Pseudomonas
aeruginosa)
PF14539
(DUF4442)
5 GLY A  53
ALA A  54
LEU A  58
LEU A  61
LEU A  36
None
0.95A 4o1zA-1sh8A:
undetectable
4o1zA-1sh8A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT


(Klebsiella
oxytoca)
PF02286
(Dehydratase_LU)
6 ILE A 154
ILE A 411
GLY A 193
ALA A 159
SER A 190
LEU A 186
None
1.44A 4o1zA-1uc4A:
undetectable
4o1zA-1uc4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE


(Pyrococcus
furiosus)
PF13476
(AAA_23)
no annotation
5 ILE A 146
ILE B 839
ALA B 799
LEU B 800
LEU A 147
None
0.96A 4o1zA-1us8A:
undetectable
4o1zA-1us8A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE


(Thermus
thermophilus)
PF00155
(Aminotran_1_2)
6 ILE A 189
GLY A  86
ALA A  87
LEU A  91
LEU A  94
LEU A  95
None
PLP  A 510 (-3.4A)
PLP  A 510 (-3.3A)
None
None
None
1.42A 4o1zA-1v2dA:
undetectable
4o1zA-1v2dA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE


(Thermus
thermophilus)
PF00155
(Aminotran_1_2)
6 ILE A 189
GLY A 232
ALA A  87
LEU A  91
LEU A  94
LEU A  95
None
None
PLP  A 510 (-3.3A)
None
None
None
1.33A 4o1zA-1v2dA:
undetectable
4o1zA-1v2dA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE


(Thermus
thermophilus)
PF00155
(Aminotran_1_2)
5 ILE A 189
VAL A 217
GLY A  86
LEU A  94
LEU A  95
None
None
PLP  A 510 (-3.4A)
None
None
0.93A 4o1zA-1v2dA:
undetectable
4o1zA-1v2dA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlm SAM-DEPENDENT
METHYLTRANSFERASE


(Thermotoga
maritima)
PF08241
(Methyltransf_11)
5 ILE A 100
GLY A 167
ALA A 166
LEU A 162
LEU A 159
None
0.99A 4o1zA-1vlmA:
undetectable
4o1zA-1vlmA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT


(Corynebacterium
sp. U-96)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4)
5 ILE A 636
GLY A 695
ALA A 696
LEU A 700
LEU A 703
None
None
SO4  A2002 (-2.8A)
None
None
0.85A 4o1zA-1vrqA:
undetectable
4o1zA-1vrqA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN


(Bacillus
subtilis)
PF02113
(Peptidase_S13)
6 GLY A 413
ALA A  51
SER A  53
LEU A  54
LEU A  56
LEU A  57
None
1.44A 4o1zA-1w5dA:
undetectable
4o1zA-1w5dA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu7 HISTIDYL-TRNA
SYNTHETASE


(Thermoplasma
acidophilum)
PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His)
5 ILE A 317
ALA A 145
LEU A 149
LEU A 152
LEU A 154
None
0.90A 4o1zA-1wu7A:
undetectable
4o1zA-1wu7A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR


(Homo sapiens)
PF01462
(LRRNT)
PF13306
(LRR_5)
5 ILE C  77
LEU C 126
ILE C 151
LEU C 108
LEU C  83
None
0.95A 4o1zA-1xwdC:
undetectable
4o1zA-1xwdC:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4k 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE


(Thermus
thermophilus)
PF13561
(adh_short_C2)
6 ILE A   9
ILE A  18
ALA A 214
LEU A 218
LEU A 221
LEU A   4
None
1.48A 4o1zA-2a4kA:
undetectable
4o1zA-2a4kA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 VAL A  97
ILE A  31
GLY A  15
ALA A  11
LEU A  42
MPD  A 590 ( 4.6A)
None
None
None
None
0.92A 4o1zA-2a8xA:
undetectable
4o1zA-2a8xA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb6 TRANSCOBALAMIN II

(Bos taurus)
PF01122
(Cobalamin_bind)
6 ILE A 290
VAL A 287
GLY A 185
ALA A 187
SER A 189
LEU A 193
None
1.05A 4o1zA-2bb6A:
undetectable
4o1zA-2bb6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0z VIRUS-LIKE PARTICLE

(Pyrococcus
furiosus)
PF04454
(Linocin_M18)
5 ILE A 250
LEU A 286
GLY A 127
SER A 129
LEU A 134
None
0.86A 4o1zA-2e0zA:
undetectable
4o1zA-2e0zA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e44 INSULIN-LIKE GROWTH
FACTOR 2 MRNA
BINDING PROTEIN 3


(Homo sapiens)
PF00076
(RRM_1)
5 ILE A  85
VAL A 124
ALA A 132
LEU A 136
LEU A 139
None
0.96A 4o1zA-2e44A:
undetectable
4o1zA-2e44A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT


(Thermus
thermophilus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ILE A  15
VAL A  38
LEU A 115
GLY A 134
LEU A 281
FAD  A8482 (-4.5A)
FAD  A8482 ( 4.8A)
None
None
FAD  A8482 (-4.7A)
0.90A 4o1zA-2eq9A:
undetectable
4o1zA-2eq9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE


(Thermotoga
maritima)
PF00348
(polyprenyl_synt)
6 LEU A  20
ILE A  99
ALA A 103
LEU A 107
LEU A 110
LEU A  65
None
0.90A 4o1zA-2ftzA:
undetectable
4o1zA-2ftzA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6l HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus)
PF03479
(DUF296)
6 ILE A  51
VAL A  92
LEU A  75
GLY A  44
LEU A  70
LEU A  66
None
1.20A 4o1zA-2h6lA:
undetectable
4o1zA-2h6lA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE


(Mycobacterium
tuberculosis)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
6 VAL A 182
ILE A 250
ALA A 162
LEU A 164
LEU A 167
LEU A 227
None
1.27A 4o1zA-2i3aA:
undetectable
4o1zA-2i3aA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1


(Anopheles
gambiae)
PF00481
(PP2C)
5 LEU A  61
ILE A 103
GLY A 179
LEU A 280
LEU A 188
None
0.99A 4o1zA-2irmA:
0.0
4o1zA-2irmA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D


(Homo sapiens)
PF00069
(Pkinase)
6 ILE A 161
LEU A 129
GLY A 208
ALA A 211
LEU A 150
LEU A 106
None
1.09A 4o1zA-2jc6A:
undetectable
4o1zA-2jc6A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D


(Homo sapiens)
PF00069
(Pkinase)
6 ILE A 161
VAL A 128
LEU A 129
GLY A 208
ALA A 211
LEU A 106
None
1.43A 4o1zA-2jc6A:
undetectable
4o1zA-2jc6A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE


(Staphylococcus
aureus)
PF00294
(PfkB)
5 ILE A 200
VAL A 199
GLY A 222
ALA A 223
LEU A 303
None
0.96A 4o1zA-2jg5A:
undetectable
4o1zA-2jg5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgn ATP-DEPENDENT RNA
HELICASE DDX3X


(Homo sapiens)
PF00271
(Helicase_C)
5 ILE A 493
VAL A 445
GLY A 452
ALA A 453
LEU A 460
None
0.89A 4o1zA-2jgnA:
undetectable
4o1zA-2jgnA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbk KSHV PROTEASE

(Human
gammaherpesvirus
8)
PF00716
(Peptidase_S21)
6 ILE A  65
VAL A  11
LEU A 113
ILE A  42
GLY A  69
LEU A  34
ACT  A 601 (-4.5A)
None
None
None
None
None
1.17A 4o1zA-2pbkA:
undetectable
4o1zA-2pbkA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis)
PF00378
(ECH_1)
5 ILE A  46
ALA A  21
SER A  24
LEU A  28
LEU A  29
None
0.96A 4o1zA-2pg8A:
undetectable
4o1zA-2pg8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056


(Geobacillus
kaustophilus)
PF08282
(Hydrolase_3)
5 VAL A 222
GLY A 246
LEU A 251
LEU A 254
LEU A 256
None
0.89A 4o1zA-2pq0A:
undetectable
4o1zA-2pq0A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qbu PRECORRIN-2
METHYLTRANSFERASE


(Methanothermobacter
thermautotrophicus)
PF00590
(TP_methylase)
5 ILE A  48
LEU A  53
ILE A  62
ALA A  34
LEU A 102
None
0.96A 4o1zA-2qbuA:
undetectable
4o1zA-2qbuA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE


(Bacillus
anthracis)
PF13561
(adh_short_C2)
5 ILE A  20
GLY A  23
SER A  27
LEU A  28
LEU A   4
NAD  A 501 (-3.9A)
None
None
None
None
0.90A 4o1zA-2qioA:
undetectable
4o1zA-2qioA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpt EH DOMAIN-CONTAINING
PROTEIN-2


(Mus musculus)
PF00350
(Dynamin_N)
PF12763
(EF-hand_4)
PF16880
(EHD_N)
5 ILE A 151
VAL A  63
GLY A  70
LEU A  78
LEU A  79
None
None
ANP  A 600 (-3.0A)
None
None
0.97A 4o1zA-2qptA:
undetectable
4o1zA-2qptA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME


(Aeropyrum
pernix)
PF00326
(Peptidase_S9)
5 ILE A  78
ALA A 138
LEU A 139
LEU A  92
LEU A 106
None
0.92A 4o1zA-2qzpA:
undetectable
4o1zA-2qzpA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1h HEMOGLOBIN SUBUNIT
BETA-4


(Oncorhynchus
mykiss)
PF00042
(Globin)
5 ILE B 110
VAL B 114
LEU B 118
GLY B  13
LEU B  71
None
0.94A 4o1zA-2r1hB:
undetectable
4o1zA-2r1hB:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II


(Streptococcus
pneumoniae)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 ILE A 390
VAL A 402
GLY A 278
ALA A 279
LEU A 322
None
0.72A 4o1zA-2rjtA:
undetectable
4o1zA-2rjtA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor)
PF01565
(FAD_binding_4)
PF04030
(ALO)
5 ILE A 149
VAL A 137
LEU A 172
LEU A 166
LEU A 397
None
0.98A 4o1zA-2vfvA:
undetectable
4o1zA-2vfvA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhe ACETYLTRANSFERASE

(Campylobacter
jejuni)
PF00132
(Hexapep)
5 GLY A 174
ALA A 175
LEU A 177
LEU A 160
LEU A 163
None
0.89A 4o1zA-2vheA:
undetectable
4o1zA-2vheA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9f CELL DIVISION
PROTEIN KINASE 4


(Homo sapiens)
PF00069
(Pkinase)
5 LEU B 161
ALA B 157
LEU B 156
LEU B 131
LEU B 128
None
0.94A 4o1zA-2w9fB:
undetectable
4o1zA-2w9fB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdt UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE L3


(Plasmodium
falciparum)
PF01088
(Peptidase_C12)
6 ILE A  53
VAL A 167
LEU A 178
GLY A 102
LEU A  97
LEU A  17
None
1.27A 4o1zA-2wdtA:
undetectable
4o1zA-2wdtA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1


(Mycobacterium
tuberculosis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 ILE A 178
GLY A 174
ALA A 352
LEU A 353
LEU A 343
None
0.95A 4o1zA-2wgeA:
undetectable
4o1zA-2wgeA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsb GALACTITOL
DEHYDROGENASE


(Rhodobacter
sphaeroides)
PF13561
(adh_short_C2)
6 ILE A  88
VAL A  90
ILE A  23
ALA A 226
LEU A 230
LEU A   9
None
None
NAD  A 500 (-3.9A)
None
None
None
1.44A 4o1zA-2wsbA:
undetectable
4o1zA-2wsbA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE


(Nocardia
farcinica)
no annotation 5 GLY A 221
ALA A 222
LEU A 226
LEU A 229
LEU A 231
None
0.88A 4o1zA-2xecA:
undetectable
4o1zA-2xecA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
BETA SUBUNIT


(Desulfomicrobium
norvegicum)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF12838
(Fer4_7)
5 VAL B 162
LEU B 166
GLY B  69
ALA B  70
LEU B  72
None
0.95A 4o1zA-2xsjB:
undetectable
4o1zA-2xsjB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
SUBUNIT 2


(Thermus
thermophilus)
PF00034
(Cytochrom_C)
PF00116
(COX2)
PF02790
(COX2_TM)
5 VAL B 149
ILE B 113
GLY B 115
ALA B 116
LEU B 135
None
0.96A 4o1zA-2yevB:
undetectable
4o1zA-2yevB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeb SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL


(Sus scrofa)
PF01127
(Sdh_cyt)
5 ILE C  50
ALA C  54
SER C  57
LEU C  58
LEU C  61
None
0.93A 4o1zA-3aebC:
undetectable
4o1zA-3aebC:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE


(Pyrococcus
horikoshii)
PF00150
(Cellulase)
5 ILE A 140
GLY A  65
ALA A 100
LEU A 103
LEU A 152
None
0.97A 4o1zA-3axxA:
undetectable
4o1zA-3axxA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axy 14-3-3-LIKE PROTEIN
GF14-C


(Oryza sativa)
PF00244
(14-3-3)
5 ILE C  54
ILE C 185
ALA C 134
LEU C 133
LEU C  94
None
0.96A 4o1zA-3axyC:
undetectable
4o1zA-3axyC:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense)
PF00326
(Peptidase_S9)
5 ILE A 256
GLY A 319
LEU A 321
LEU A 267
LEU A 280
None
0.96A 4o1zA-3azqA:
undetectable
4o1zA-3azqA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9p CG5977-PA, ISOFORM A

(Drosophila
melanogaster)
PF00004
(AAA)
PF09336
(Vps4_C)
5 ILE A 473
ALA A 549
SER A 551
LEU A 552
LEU A 563
None
0.95A 4o1zA-3b9pA:
undetectable
4o1zA-3b9pA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcz PROTEIN MEMO1

(Homo sapiens)
PF01875
(Memo)
5 ILE A  46
VAL A 186
LEU A  77
GLY A 170
LEU A 253
None
0.98A 4o1zA-3bczA:
undetectable
4o1zA-3bczA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bio OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY


(Porphyromonas
gingivalis)
PF01408
(GFO_IDH_MocA)
PF16654
(DAPDH_C)
5 ILE A  33
ILE A  87
ALA A  66
LEU A  25
LEU A  22
None
0.78A 4o1zA-3bioA:
undetectable
4o1zA-3bioA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR


(Mycobacterium
tuberculosis)
PF00072
(Response_reg)
PF00196
(GerE)
5 ILE A  63
VAL A  55
LEU A 188
LEU A 161
LEU A 158
None
0.94A 4o1zA-3c3wA:
undetectable
4o1zA-3c3wA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6l TCR 2W20 ALPHA CHAIN

(Mus musculus)
PF07686
(V-set)
PF09291
(DUF1968)
5 LEU A  45
ILE A  99
ALA A  90
LEU A  74
LEU A  20
None
0.95A 4o1zA-3c6lA:
undetectable
4o1zA-3c6lA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE


(Escherichia
coli)
PF02798
(GST_N)
PF13410
(GST_C_2)
5 ILE A 121
GLY A  72
ALA A  73
LEU A 104
LEU A  47
None
0.84A 4o1zA-3c8eA:
0.0
4o1zA-3c8eA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cng NUDIX HYDROLASE

(Nitrosomonas
europaea)
PF00293
(NUDIX)
PF14803
(Nudix_N_2)
6 ILE A 146
ILE A  40
GLY A  70
ALA A  69
LEU A  67
LEU A  53
None
GOL  A 501 (-4.8A)
NA  A 512 ( 4.2A)
None
None
None
1.37A 4o1zA-3cngA:
undetectable
4o1zA-3cngA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622


(Lactobacillus
plantarum)
PF04263
(TPK_catalytic)
5 ILE A  70
VAL A  72
ALA A  84
SER A  87
LEU A  92
None
0.88A 4o1zA-3cq9A:
undetectable
4o1zA-3cq9A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkn PREPROTEIN
TRANSLOCASE SUBUNIT
SECY


(Canis lupus)
PF00344
(SecY)
5 ILE A 210
ILE A 182
GLY A 185
ALA A 186
LEU A 193
None
0.91A 4o1zA-3dknA:
undetectable
4o1zA-3dknA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkx REPLICATION PROTEIN
REPB


(Streptococcus
agalactiae)
PF01719
(Rep_2)
5 MET A  33
ILE A  75
VAL A  71
LEU A  84
LEU A  13
None
0.97A 4o1zA-3dkxA:
undetectable
4o1zA-3dkxA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ILE A 274
LEU A 339
ILE A 399
ALA A 250
LEU A 290
None
0.98A 4o1zA-3dtcA:
undetectable
4o1zA-3dtcA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN


(Plexaura
homomalla)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
5 LEU A 964
GLY A 745
ALA A 747
SER A 749
LEU A 754
None
0.87A 4o1zA-3dy5A:
undetectable
4o1zA-3dy5A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egc PUTATIVE RIBOSE
OPERON REPRESSOR


(Burkholderia
thailandensis)
PF00532
(Peripla_BP_1)
5 GLY A 259
ALA A 260
LEU A 264
LEU A 267
LEU A 269
None
0.91A 4o1zA-3egcA:
undetectable
4o1zA-3egcA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3err FUSION PROTEIN OF
MICROTUBULE BINDING
DOMAIN FROM MOUSE
CYTOPLASMIC DYNEIN
AND SERYL-TRNA
SYNTHETASE FROM
THERMUS THERMOPHILUS


(Mus musculus;
Thermus
thermophilus)
PF00587
(tRNA-synt_2b)
PF12777
(MT)
5 ILE A 387
ALA A 302
LEU A 306
LEU A 309
LEU A 311
None
0.94A 4o1zA-3errA:
undetectable
4o1zA-3errA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1


(Homo sapiens)
PF00069
(Pkinase)
5 ILE A 173
LEU A 232
TRP A 289
ILE A 284
LEU A 182
None
0.89A 4o1zA-3f2aA:
undetectable
4o1zA-3f2aA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB


(Escherichia
coli)
PF04449
(Fimbrial_CS1)
PF07434
(CblD)
5 ILE A 100
ILE A  94
GLY A  96
ALA A 135
LEU A 155
None
0.99A 4o1zA-3f83A:
undetectable
4o1zA-3f83A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC


(Cytophaga
hutchinsonii)
PF00266
(Aminotran_5)
7 ILE A 202
VAL A 200
ILE A 248
GLY A 252
ALA A  47
LEU A  55
LEU A  57
None
1.22A 4o1zA-3ffrA:
undetectable
4o1zA-3ffrA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gff IROE-LIKE SERINE
HYDROLASE


(Shewanella
oneidensis)
PF00756
(Esterase)
5 ILE A  76
VAL A  78
ILE A 120
ALA A 125
LEU A 132
None
0.79A 4o1zA-3gffA:
undetectable
4o1zA-3gffA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609


(Methanocaldococcus
jannaschii)
PF13520
(AA_permease_2)
5 LEU C 162
ILE C 276
GLY C 279
ALA C 280
SER C 283
None
0.85A 4o1zA-3gi8C:
1.0
4o1zA-3gi8C:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE


(Vibrio cholerae)
PF00342
(PGI)
6 ILE A 478
LEU A 294
TRP A 275
ILE A 282
GLY A 162
LEU A 343
None
1.43A 4o1zA-3hjbA:
undetectable
4o1zA-3hjbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE


(Solanum
lycopersicum)
PF00082
(Peptidase_S8)
6 ILE A 374
VAL A 373
ILE A 466
GLY A 441
ALA A 421
LEU A 419
None
1.46A 4o1zA-3i6sA:
undetectable
4o1zA-3i6sA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2z LEXA REPRESSOR

(Thermotoga
maritima)
PF00717
(Peptidase_S24)
PF01726
(LexA_DNA_bind)
6 ILE A  15
VAL A  11
ILE A  37
GLY A  41
ALA A  42
LEU A  65
None
1.14A 4o1zA-3k2zA:
undetectable
4o1zA-3k2zA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khj INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE


(Cryptosporidium
parvum)
PF00478
(IMPDH)
5 ILE A 188
ILE A 235
GLY A 268
ALA A 269
LEU A  35
None
0.94A 4o1zA-3khjA:
undetectable
4o1zA-3khjA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6y CATENIN DELTA-1

(Homo sapiens)
PF00514
(Arm)
5 LEU A 666
ILE A 682
GLY A 680
ALA A 681
LEU A 583
None
0.98A 4o1zA-3l6yA:
0.9
4o1zA-3l6yA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lst CALO1
METHYLTRANSFERASE


(Micromonospora
echinospora)
PF00891
(Methyltransf_2)
5 VAL A 247
ILE A 339
GLY A 177
LEU A 206
LEU A 200
None
0.98A 4o1zA-3lstA:
undetectable
4o1zA-3lstA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2


(Drosophila
melanogaster)
PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N)
6 VAL X 367
ILE X  40
GLY X 470
ALA X 473
LEU X 475
LEU X 524
None
1.41A 4o1zA-3lxuX:
0.0
4o1zA-3lxuX:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1l 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE


(Mycobacterium
tuberculosis)
PF13561
(adh_short_C2)
5 ILE A 444
VAL A 388
LEU A 345
ILE A 229
ALA A 425
None
0.92A 4o1zA-3m1lA:
undetectable
4o1zA-3m1lA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN


(Schizosaccharomyces
pombe)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
6 ILE A 273
VAL A 283
LEU A 284
LEU A 313
LEU A 310
LEU A 309
None
1.44A 4o1zA-3mcaA:
undetectable
4o1zA-3mcaA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE


(Vibrio
vulnificus)
PF02784
(Orn_Arg_deC_N)
5 ILE A  81
LEU A  74
GLY A 549
ALA A 350
LEU A 296
None
0.97A 4o1zA-3n2oA:
undetectable
4o1zA-3n2oA:
20.79