SIMILAR PATTERNS OF AMINO ACIDS FOR 4O1Z_A_MXMA807_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b0a | PROTEIN (FOLDBIFUNCTIONALPROTEIN) (Escherichiacoli) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 6 | VAL A 147LEU A 150GLY A 183ALA A 182LEU A 181LEU A 131 | None | 1.39A | 4o1zA-1b0aA:0.0 | 4o1zA-1b0aA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b25 | PROTEIN(FORMALDEHYDEFERREDOXINOXIDOREDUCTASE) (Pyrococcusfuriosus) |
PF01314(AFOR_C)PF02730(AFOR_N) | 6 | MET A 241ILE A 269VAL A 325LEU A 328GLY A 343LEU A 253 | None | 1.04A | 4o1zA-1b25A:0.0 | 4o1zA-1b25A:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ebd | DIHYDROLIPOAMIDEDEHYDROGENASE (Geobacillusstearothermophilus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | VAL A 103ILE A 37GLY A 21ALA A 17LEU A 48 | None | 0.97A | 4o1zA-1ebdA:0.0 | 4o1zA-1ebdA:20.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ebv | PROSTAGLANDIN H2SYNTHASE (Ovis aries) |
PF00008(EGF)PF03098(An_peroxidase) | 7 | ILE A 345VAL A 349LEU A 352TRP A 387GLY A 526ALA A 527LEU A 117 | NoneSCL A 700 ( 4.6A)SCL A 700 ( 4.8A)NoneSCL A 700 ( 4.0A)SCL A 700 (-2.9A)None | 1.29A | 4o1zA-1ebvA:62.2 | 4o1zA-1ebvA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ebv | PROSTAGLANDIN H2SYNTHASE (Ovis aries) |
PF00008(EGF)PF03098(An_peroxidase) | 10 | MET A 113ILE A 345VAL A 349LEU A 352TRP A 387ILE A 523GLY A 526ALA A 527LEU A 534LEU A 535 | NoneNoneSCL A 700 ( 4.6A)SCL A 700 ( 4.8A)NoneSCL A 700 (-3.4A)SCL A 700 ( 4.0A)SCL A 700 (-2.9A)OAS A 530 ( 3.3A)None | 0.56A | 4o1zA-1ebvA:62.2 | 4o1zA-1ebvA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ebv | PROSTAGLANDIN H2SYNTHASE (Ovis aries) |
PF00008(EGF)PF03098(An_peroxidase) | 7 | MET A 113ILE A 523GLY A 526ALA A 527LEU A 531LEU A 534LEU A 535 | NoneSCL A 700 (-3.4A)SCL A 700 ( 4.0A)SCL A 700 (-2.9A)OAS A 530 (-4.1A)OAS A 530 ( 3.3A)None | 1.07A | 4o1zA-1ebvA:62.2 | 4o1zA-1ebvA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1evj | GLUCOSE-FRUCTOSEOXIDOREDUCTASE (Zymomonasmobilis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | GLY A 207ALA A 206SER A 109LEU A 110LEU A 106 | NoneNoneNoneNoneNAD A 500 (-3.9A) | 0.92A | 4o1zA-1evjA:0.0 | 4o1zA-1evjA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1evq | SERINE HYDROLASE (Alicyclobacillusacidocaldarius) |
PF07859(Abhydrolase_3) | 5 | ILE A 182ILE A 7GLY A 293ALA A 294LEU A 298 | None | 0.84A | 4o1zA-1evqA:0.0 | 4o1zA-1evqA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f8w | NADH PEROXIDASE (Enterococcusfaecalis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ILE A 28VAL A 5GLY A 11LEU A 19LEU A 20 | NoneNoneFAD A 448 (-3.7A)NoneNone | 0.97A | 4o1zA-1f8wA:0.0 | 4o1zA-1f8wA:21.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h6d | PRECURSOR FORM OFGLUCOSE-FRUCTOSEOXIDOREDUCTASE (Zymomonasmobilis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | GLY A 259ALA A 258SER A 161LEU A 162LEU A 158 | NoneNoneNoneNoneNDP A 500 (-4.1A) | 0.92A | 4o1zA-1h6dA:0.0 | 4o1zA-1h6dA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h7z | ADENOVIRUS FIBREPROTEIN (HumanmastadenovirusB) |
PF00541(Adeno_knob) | 6 | MET A 230ILE A 203GLY A 136LEU A 158LEU A 210LEU A 195 | None | 1.40A | 4o1zA-1h7zA:0.0 | 4o1zA-1h7zA:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hcu | ALPHA-1,2-MANNOSIDASE (Trichodermareesei) |
PF01532(Glyco_hydro_47) | 5 | ILE A 66GLY A 107SER A 111LEU A 115LEU A 116 | None | 0.91A | 4o1zA-1hcuA:0.0 | 4o1zA-1hcuA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1icp | 12-OXOPHYTODIENOATEREDUCTASE 1 (Solanumlycopersicum) |
PF00724(Oxidored_FMN) | 5 | LEU A 326GLY A 23ALA A 271LEU A 270LEU A 265 | None | 0.93A | 4o1zA-1icpA:undetectable | 4o1zA-1icpA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j31 | HYPOTHETICAL PROTEINPH0642 (Pyrococcushorikoshii) |
PF00795(CN_hydrolase) | 6 | ILE A 7VAL A 38LEU A 37GLY A 103ALA A 76LEU A 75 | None | 1.34A | 4o1zA-1j31A:undetectable | 4o1zA-1j31A:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j9l | STATIONARY PHASESURVIVAL PROTEIN (Thermotogamaritima) |
PF01975(SurE) | 5 | ILE A 226VAL A 224GLY A 138ALA A 139LEU A 143 | None | 0.85A | 4o1zA-1j9lA:undetectable | 4o1zA-1j9lA:17.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jmy | BILE-SALT-ACTIVATEDLIPASE (Homo sapiens) |
PF00135(COesterase) | 5 | GLY A 197ALA A 198SER A 201LEU A 202LEU A 205 | None | 0.71A | 4o1zA-1jmyA:undetectable | 4o1zA-1jmyA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lq2 | BETA-D-GLUCANGLUCOHYDROLASEISOENZYME EXO1 (Hordeum vulgare) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C) | 5 | ILE A 342VAL A 346ILE A 88GLY A 51LEU A 328 | None | 0.97A | 4o1zA-1lq2A:undetectable | 4o1zA-1lq2A:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lt8 | BETAINE-HOMOCYSTEINEMETHYLTRANSFERASE (Homo sapiens) |
PF02574(S-methyl_trans) | 6 | ILE A 13GLY A 209ALA A 210SER A 211LEU A 14LEU A 17 | None | 1.24A | 4o1zA-1lt8A:undetectable | 4o1zA-1lt8A:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lt8 | BETAINE-HOMOCYSTEINEMETHYLTRANSFERASE (Homo sapiens) |
PF02574(S-methyl_trans) | 6 | MET A 245ILE A 13GLY A 209ALA A 210LEU A 14LEU A 17 | None | 1.41A | 4o1zA-1lt8A:undetectable | 4o1zA-1lt8A:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o8b | RIBOSE 5-PHOSPHATEISOMERASE (Escherichiacoli) |
PF06026(Rib_5-P_isom_A) | 5 | ILE A 189VAL A 192GLY A 196LEU A 147LEU A 150 | None | 0.95A | 4o1zA-1o8bA:undetectable | 4o1zA-1o8bA:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1og6 | HYPOTHETICALOXIDOREDUCTASE YDHF (Escherichiacoli) |
PF00248(Aldo_ket_red) | 5 | ILE A 80ALA A 110SER A 113LEU A 114LEU A 117 | None | 0.88A | 4o1zA-1og6A:undetectable | 4o1zA-1og6A:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1px8 | BETA-XYLOSIDASE (Thermoanaerobacteriumsaccharolyticum) |
PF01229(Glyco_hydro_39) | 5 | ILE A 82ILE A 36ALA A 30LEU A 27LEU A 56 | None | 0.89A | 4o1zA-1px8A:undetectable | 4o1zA-1px8A:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s9i | DUAL SPECIFICITYMITOGEN-ACTIVATEDPROTEIN KINASEKINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 6 | ILE A 200VAL A 177LEU A 178ILE A 369LEU A 170LEU A 260 | None | 1.23A | 4o1zA-1s9iA:undetectable | 4o1zA-1s9iA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ser | PROTEIN (SERYL-TRNASYNTHETASE(E.C.6.1.1.11)) (Thermusthermophilus) |
PF00587(tRNA-synt_2b)PF02403(Seryl_tRNA_N) | 5 | ILE A 387ALA A 302LEU A 306LEU A 309LEU A 311 | None | 0.96A | 4o1zA-1serA:undetectable | 4o1zA-1serA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sh8 | HYPOTHETICAL PROTEINPA5026 (Pseudomonasaeruginosa) |
PF14539(DUF4442) | 5 | GLY A 53ALA A 54LEU A 58LEU A 61LEU A 36 | None | 0.95A | 4o1zA-1sh8A:undetectable | 4o1zA-1sh8A:13.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uc4 | DIOL DEHYDRASE ALPHASUBUNIT (Klebsiellaoxytoca) |
PF02286(Dehydratase_LU) | 6 | ILE A 154ILE A 411GLY A 193ALA A 159SER A 190LEU A 186 | None | 1.44A | 4o1zA-1uc4A:undetectable | 4o1zA-1uc4A:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1us8 | DNA DOUBLE-STRANDBREAK REPAIR RAD50ATPASE (Pyrococcusfuriosus) |
PF13476(AAA_23)no annotation | 5 | ILE A 146ILE B 839ALA B 799LEU B 800LEU A 147 | None | 0.96A | 4o1zA-1us8A:undetectable | 4o1zA-1us8A:12.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v2d | GLUTAMINEAMINOTRANSFERASE (Thermusthermophilus) |
PF00155(Aminotran_1_2) | 6 | ILE A 189GLY A 86ALA A 87LEU A 91LEU A 94LEU A 95 | NonePLP A 510 (-3.4A)PLP A 510 (-3.3A)NoneNoneNone | 1.42A | 4o1zA-1v2dA:undetectable | 4o1zA-1v2dA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v2d | GLUTAMINEAMINOTRANSFERASE (Thermusthermophilus) |
PF00155(Aminotran_1_2) | 6 | ILE A 189GLY A 232ALA A 87LEU A 91LEU A 94LEU A 95 | NoneNonePLP A 510 (-3.3A)NoneNoneNone | 1.33A | 4o1zA-1v2dA:undetectable | 4o1zA-1v2dA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v2d | GLUTAMINEAMINOTRANSFERASE (Thermusthermophilus) |
PF00155(Aminotran_1_2) | 5 | ILE A 189VAL A 217GLY A 86LEU A 94LEU A 95 | NoneNonePLP A 510 (-3.4A)NoneNone | 0.93A | 4o1zA-1v2dA:undetectable | 4o1zA-1v2dA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vlm | SAM-DEPENDENTMETHYLTRANSFERASE (Thermotogamaritima) |
PF08241(Methyltransf_11) | 5 | ILE A 100GLY A 167ALA A 166LEU A 162LEU A 159 | None | 0.99A | 4o1zA-1vlmA:undetectable | 4o1zA-1vlmA:17.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vrq | SARCOSINE OXIDASEALPHA SUBUNIT (Corynebacteriumsp. U-96) |
PF01571(GCV_T)PF08669(GCV_T_C)PF12831(FAD_oxidored)PF13510(Fer2_4) | 5 | ILE A 636GLY A 695ALA A 696LEU A 700LEU A 703 | NoneNoneSO4 A2002 (-2.8A)NoneNone | 0.85A | 4o1zA-1vrqA:undetectable | 4o1zA-1vrqA:19.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w5d | PENICILLIN-BINDINGPROTEIN (Bacillussubtilis) |
PF02113(Peptidase_S13) | 6 | GLY A 413ALA A 51SER A 53LEU A 54LEU A 56LEU A 57 | None | 1.44A | 4o1zA-1w5dA:undetectable | 4o1zA-1w5dA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wu7 | HISTIDYL-TRNASYNTHETASE (Thermoplasmaacidophilum) |
PF03129(HGTP_anticodon)PF13393(tRNA-synt_His) | 5 | ILE A 317ALA A 145LEU A 149LEU A 152LEU A 154 | None | 0.90A | 4o1zA-1wu7A:undetectable | 4o1zA-1wu7A:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xwd | FOLLICLE STIMULATINGHORMONE RECEPTOR (Homo sapiens) |
PF01462(LRRNT)PF13306(LRR_5) | 5 | ILE C 77LEU C 126ILE C 151LEU C 108LEU C 83 | None | 0.95A | 4o1zA-1xwdC:undetectable | 4o1zA-1xwdC:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a4k | 3-OXOACYL-[ACYLCARRIER PROTEIN]REDUCTASE (Thermusthermophilus) |
PF13561(adh_short_C2) | 6 | ILE A 9ILE A 18ALA A 214LEU A 218LEU A 221LEU A 4 | None | 1.48A | 4o1zA-2a4kA:undetectable | 4o1zA-2a4kA:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a8x | DIHYDROLIPOYLDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | VAL A 97ILE A 31GLY A 15ALA A 11LEU A 42 | MPD A 590 ( 4.6A)NoneNoneNoneNone | 0.92A | 4o1zA-2a8xA:undetectable | 4o1zA-2a8xA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bb6 | TRANSCOBALAMIN II (Bos taurus) |
PF01122(Cobalamin_bind) | 6 | ILE A 290VAL A 287GLY A 185ALA A 187SER A 189LEU A 193 | None | 1.05A | 4o1zA-2bb6A:undetectable | 4o1zA-2bb6A:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0z | VIRUS-LIKE PARTICLE (Pyrococcusfuriosus) |
PF04454(Linocin_M18) | 5 | ILE A 250LEU A 286GLY A 127SER A 129LEU A 134 | None | 0.86A | 4o1zA-2e0zA:undetectable | 4o1zA-2e0zA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e44 | INSULIN-LIKE GROWTHFACTOR 2 MRNABINDING PROTEIN 3 (Homo sapiens) |
PF00076(RRM_1) | 5 | ILE A 85VAL A 124ALA A 132LEU A 136LEU A 139 | None | 0.96A | 4o1zA-2e44A:undetectable | 4o1zA-2e44A:10.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eq9 | PYRUVATEDEHYDROGENASECOMPLEX,DIHYDROLIPOAMIDEDEHYDROGENASE E3COMPONENT (Thermusthermophilus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ILE A 15VAL A 38LEU A 115GLY A 134LEU A 281 | FAD A8482 (-4.5A)FAD A8482 ( 4.8A)NoneNoneFAD A8482 (-4.7A) | 0.90A | 4o1zA-2eq9A:undetectable | 4o1zA-2eq9A:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ftz | GERANYLTRANSTRANSFERASE (Thermotogamaritima) |
PF00348(polyprenyl_synt) | 6 | LEU A 20ILE A 99ALA A 103LEU A 107LEU A 110LEU A 65 | None | 0.90A | 4o1zA-2ftzA:undetectable | 4o1zA-2ftzA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h6l | HYPOTHETICAL PROTEIN (Archaeoglobusfulgidus) |
PF03479(DUF296) | 6 | ILE A 51VAL A 92LEU A 75GLY A 44LEU A 70LEU A 66 | None | 1.20A | 4o1zA-2h6lA:undetectable | 4o1zA-2h6lA:12.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i3a | N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Mycobacteriumtuberculosis) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 6 | VAL A 182ILE A 250ALA A 162LEU A 164LEU A 167LEU A 227 | None | 1.27A | 4o1zA-2i3aA:undetectable | 4o1zA-2i3aA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2irm | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE 7INTERACTING PROTEIN1 (Anophelesgambiae) |
PF00481(PP2C) | 5 | LEU A 61ILE A 103GLY A 179LEU A 280LEU A 188 | None | 0.99A | 4o1zA-2irmA:0.0 | 4o1zA-2irmA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jc6 | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE 1D (Homo sapiens) |
PF00069(Pkinase) | 6 | ILE A 161LEU A 129GLY A 208ALA A 211LEU A 150LEU A 106 | None | 1.09A | 4o1zA-2jc6A:undetectable | 4o1zA-2jc6A:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jc6 | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE 1D (Homo sapiens) |
PF00069(Pkinase) | 6 | ILE A 161VAL A 128LEU A 129GLY A 208ALA A 211LEU A 106 | None | 1.43A | 4o1zA-2jc6A:undetectable | 4o1zA-2jc6A:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jg5 | FRUCTOSE 1-PHOSPHATEKINASE (Staphylococcusaureus) |
PF00294(PfkB) | 5 | ILE A 200VAL A 199GLY A 222ALA A 223LEU A 303 | None | 0.96A | 4o1zA-2jg5A:undetectable | 4o1zA-2jg5A:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jgn | ATP-DEPENDENT RNAHELICASE DDX3X (Homo sapiens) |
PF00271(Helicase_C) | 5 | ILE A 493VAL A 445GLY A 452ALA A 453LEU A 460 | None | 0.89A | 4o1zA-2jgnA:undetectable | 4o1zA-2jgnA:13.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pbk | KSHV PROTEASE (Humangammaherpesvirus8) |
PF00716(Peptidase_S21) | 6 | ILE A 65VAL A 11LEU A 113ILE A 42GLY A 69LEU A 34 | ACT A 601 (-4.5A)NoneNoneNoneNoneNone | 1.17A | 4o1zA-2pbkA:undetectable | 4o1zA-2pbkA:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pg8 | DPGC (Streptomycestoyocaensis) |
PF00378(ECH_1) | 5 | ILE A 46ALA A 21SER A 24LEU A 28LEU A 29 | None | 0.96A | 4o1zA-2pg8A:undetectable | 4o1zA-2pg8A:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pq0 | HYPOTHETICALCONSERVED PROTEINGK1056 (Geobacilluskaustophilus) |
PF08282(Hydrolase_3) | 5 | VAL A 222GLY A 246LEU A 251LEU A 254LEU A 256 | None | 0.89A | 4o1zA-2pq0A:undetectable | 4o1zA-2pq0A:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qbu | PRECORRIN-2METHYLTRANSFERASE (Methanothermobacterthermautotrophicus) |
PF00590(TP_methylase) | 5 | ILE A 48LEU A 53ILE A 62ALA A 34LEU A 102 | None | 0.96A | 4o1zA-2qbuA:undetectable | 4o1zA-2qbuA:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qio | ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (Bacillusanthracis) |
PF13561(adh_short_C2) | 5 | ILE A 20GLY A 23SER A 27LEU A 28LEU A 4 | NAD A 501 (-3.9A)NoneNoneNoneNone | 0.90A | 4o1zA-2qioA:undetectable | 4o1zA-2qioA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qpt | EH DOMAIN-CONTAININGPROTEIN-2 (Mus musculus) |
PF00350(Dynamin_N)PF12763(EF-hand_4)PF16880(EHD_N) | 5 | ILE A 151VAL A 63GLY A 70LEU A 78LEU A 79 | NoneNoneANP A 600 (-3.0A)NoneNone | 0.97A | 4o1zA-2qptA:undetectable | 4o1zA-2qptA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzp | ACYLAMINO-ACID-RELEASING ENZYME (Aeropyrumpernix) |
PF00326(Peptidase_S9) | 5 | ILE A 78ALA A 138LEU A 139LEU A 92LEU A 106 | None | 0.92A | 4o1zA-2qzpA:undetectable | 4o1zA-2qzpA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r1h | HEMOGLOBIN SUBUNITBETA-4 (Oncorhynchusmykiss) |
PF00042(Globin) | 5 | ILE B 110VAL B 114LEU B 118GLY B 13LEU B 71 | None | 0.94A | 4o1zA-2r1hB:undetectable | 4o1zA-2r1hB:14.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rjt | BETA-KETOACYL-ACPSYNTHASE II (Streptococcuspneumoniae) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ILE A 390VAL A 402GLY A 278ALA A 279LEU A 322 | None | 0.72A | 4o1zA-2rjtA:undetectable | 4o1zA-2rjtA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vfv | XYLITOL OXIDASE (Streptomycescoelicolor) |
PF01565(FAD_binding_4)PF04030(ALO) | 5 | ILE A 149VAL A 137LEU A 172LEU A 166LEU A 397 | None | 0.98A | 4o1zA-2vfvA:undetectable | 4o1zA-2vfvA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vhe | ACETYLTRANSFERASE (Campylobacterjejuni) |
PF00132(Hexapep) | 5 | GLY A 174ALA A 175LEU A 177LEU A 160LEU A 163 | None | 0.89A | 4o1zA-2vheA:undetectable | 4o1zA-2vheA:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w9f | CELL DIVISIONPROTEIN KINASE 4 (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU B 161ALA B 157LEU B 156LEU B 131LEU B 128 | None | 0.94A | 4o1zA-2w9fB:undetectable | 4o1zA-2w9fB:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wdt | UBIQUITINCARBOXYL-TERMINALHYDROLASE L3 (Plasmodiumfalciparum) |
PF01088(Peptidase_C12) | 6 | ILE A 53VAL A 167LEU A 178GLY A 102LEU A 97LEU A 17 | None | 1.27A | 4o1zA-2wdtA:undetectable | 4o1zA-2wdtA:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wge | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 1 (Mycobacteriumtuberculosis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ILE A 178GLY A 174ALA A 352LEU A 353LEU A 343 | None | 0.95A | 4o1zA-2wgeA:undetectable | 4o1zA-2wgeA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsb | GALACTITOLDEHYDROGENASE (Rhodobactersphaeroides) |
PF13561(adh_short_C2) | 6 | ILE A 88VAL A 90ILE A 23ALA A 226LEU A 230LEU A 9 | NoneNoneNAD A 500 (-3.9A)NoneNoneNone | 1.44A | 4o1zA-2wsbA:undetectable | 4o1zA-2wsbA:17.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xec | PUTATIVE MALEATEISOMERASE (Nocardiafarcinica) |
no annotation | 5 | GLY A 221ALA A 222LEU A 226LEU A 229LEU A 231 | None | 0.88A | 4o1zA-2xecA:undetectable | 4o1zA-2xecA:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xsj | SULFITE REDUCTASEBETA SUBUNIT (Desulfomicrobiumnorvegicum) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr)PF12838(Fer4_7) | 5 | VAL B 162LEU B 166GLY B 69ALA B 70LEU B 72 | None | 0.95A | 4o1zA-2xsjB:undetectable | 4o1zA-2xsjB:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yev | CYTOCHROME C OXIDASESUBUNIT 2 (Thermusthermophilus) |
PF00034(Cytochrom_C)PF00116(COX2)PF02790(COX2_TM) | 5 | VAL B 149ILE B 113GLY B 115ALA B 116LEU B 135 | None | 0.96A | 4o1zA-2yevB:undetectable | 4o1zA-2yevB:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aeb | SUCCINATEDEHYDROGENASECYTOCHROME B560SUBUNIT,MITOCHONDRIAL (Sus scrofa) |
PF01127(Sdh_cyt) | 5 | ILE C 50ALA C 54SER C 57LEU C 58LEU C 61 | None | 0.93A | 4o1zA-3aebC:undetectable | 4o1zA-3aebC:15.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3axx | 458AA LONGHYPOTHETICALENDO-1,4-BETA-GLUCANASE (Pyrococcushorikoshii) |
PF00150(Cellulase) | 5 | ILE A 140GLY A 65ALA A 100LEU A 103LEU A 152 | None | 0.97A | 4o1zA-3axxA:undetectable | 4o1zA-3axxA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3axy | 14-3-3-LIKE PROTEINGF14-C (Oryza sativa) |
PF00244(14-3-3) | 5 | ILE C 54ILE C 185ALA C 134LEU C 133LEU C 94 | None | 0.96A | 4o1zA-3axyC:undetectable | 4o1zA-3axyC:15.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3azq | AMINOPEPTIDASE (Streptomycesmorookaense) |
PF00326(Peptidase_S9) | 5 | ILE A 256GLY A 319LEU A 321LEU A 267LEU A 280 | None | 0.96A | 4o1zA-3azqA:undetectable | 4o1zA-3azqA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9p | CG5977-PA, ISOFORM A (Drosophilamelanogaster) |
PF00004(AAA)PF09336(Vps4_C) | 5 | ILE A 473ALA A 549SER A 551LEU A 552LEU A 563 | None | 0.95A | 4o1zA-3b9pA:undetectable | 4o1zA-3b9pA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bcz | PROTEIN MEMO1 (Homo sapiens) |
PF01875(Memo) | 5 | ILE A 46VAL A 186LEU A 77GLY A 170LEU A 253 | None | 0.98A | 4o1zA-3bczA:undetectable | 4o1zA-3bczA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bio | OXIDOREDUCTASE,GFO/IDH/MOCA FAMILY (Porphyromonasgingivalis) |
PF01408(GFO_IDH_MocA)PF16654(DAPDH_C) | 5 | ILE A 33ILE A 87ALA A 66LEU A 25LEU A 22 | None | 0.78A | 4o1zA-3bioA:undetectable | 4o1zA-3bioA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c3w | TWO COMPONENTTRANSCRIPTIONALREGULATORY PROTEINDEVR (Mycobacteriumtuberculosis) |
PF00072(Response_reg)PF00196(GerE) | 5 | ILE A 63VAL A 55LEU A 188LEU A 161LEU A 158 | None | 0.94A | 4o1zA-3c3wA:undetectable | 4o1zA-3c3wA:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c6l | TCR 2W20 ALPHA CHAIN (Mus musculus) |
PF07686(V-set)PF09291(DUF1968) | 5 | LEU A 45ILE A 99ALA A 90LEU A 74LEU A 20 | None | 0.95A | 4o1zA-3c6lA:undetectable | 4o1zA-3c6lA:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c8e | YGHU, GLUTATHIONES-TRANSFERASEHOMOLOGUE (Escherichiacoli) |
PF02798(GST_N)PF13410(GST_C_2) | 5 | ILE A 121GLY A 72ALA A 73LEU A 104LEU A 47 | None | 0.84A | 4o1zA-3c8eA:0.0 | 4o1zA-3c8eA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cng | NUDIX HYDROLASE (Nitrosomonaseuropaea) |
PF00293(NUDIX)PF14803(Nudix_N_2) | 6 | ILE A 146ILE A 40GLY A 70ALA A 69LEU A 67LEU A 53 | NoneGOL A 501 (-4.8A) NA A 512 ( 4.2A)NoneNoneNone | 1.37A | 4o1zA-3cngA:undetectable | 4o1zA-3cngA:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cq9 | UNCHARACTERIZEDPROTEIN LP_1622 (Lactobacillusplantarum) |
PF04263(TPK_catalytic) | 5 | ILE A 70VAL A 72ALA A 84SER A 87LEU A 92 | None | 0.88A | 4o1zA-3cq9A:undetectable | 4o1zA-3cq9A:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dkn | PREPROTEINTRANSLOCASE SUBUNITSECY (Canis lupus) |
PF00344(SecY) | 5 | ILE A 210ILE A 182GLY A 185ALA A 186LEU A 193 | None | 0.91A | 4o1zA-3dknA:undetectable | 4o1zA-3dknA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dkx | REPLICATION PROTEINREPB (Streptococcusagalactiae) |
PF01719(Rep_2) | 5 | MET A 33ILE A 75VAL A 71LEU A 84LEU A 13 | None | 0.97A | 4o1zA-3dkxA:undetectable | 4o1zA-3dkxA:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dtc | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE 9 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ILE A 274LEU A 339ILE A 399ALA A 250LEU A 290 | None | 0.98A | 4o1zA-3dtcA:undetectable | 4o1zA-3dtcA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dy5 | ALLENE OXIDESYNTHASE-LIPOXYGENASE PROTEIN (Plexaurahomomalla) |
PF00305(Lipoxygenase)PF01477(PLAT) | 5 | LEU A 964GLY A 745ALA A 747SER A 749LEU A 754 | None | 0.87A | 4o1zA-3dy5A:undetectable | 4o1zA-3dy5A:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egc | PUTATIVE RIBOSEOPERON REPRESSOR (Burkholderiathailandensis) |
PF00532(Peripla_BP_1) | 5 | GLY A 259ALA A 260LEU A 264LEU A 267LEU A 269 | None | 0.91A | 4o1zA-3egcA:undetectable | 4o1zA-3egcA:17.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3err | FUSION PROTEIN OFMICROTUBULE BINDINGDOMAIN FROM MOUSECYTOPLASMIC DYNEINAND SERYL-TRNASYNTHETASE FROMTHERMUS THERMOPHILUS (Mus musculus;Thermusthermophilus) |
PF00587(tRNA-synt_2b)PF12777(MT) | 5 | ILE A 387ALA A 302LEU A 306LEU A 309LEU A 311 | None | 0.94A | 4o1zA-3errA:undetectable | 4o1zA-3errA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f2a | PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE PIM-1 (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE A 173LEU A 232TRP A 289ILE A 284LEU A 182 | None | 0.89A | 4o1zA-3f2aA:undetectable | 4o1zA-3f2aA:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f83 | FUSION OF THE MINORPILIN CFAE AND MAJORPILIN CFAB (Escherichiacoli) |
PF04449(Fimbrial_CS1)PF07434(CblD) | 5 | ILE A 100ILE A 94GLY A 96ALA A 135LEU A 155 | None | 0.99A | 4o1zA-3f83A:undetectable | 4o1zA-3f83A:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ffr | PHOSPHOSERINEAMINOTRANSFERASESERC (Cytophagahutchinsonii) |
PF00266(Aminotran_5) | 7 | ILE A 202VAL A 200ILE A 248GLY A 252ALA A 47LEU A 55LEU A 57 | None | 1.22A | 4o1zA-3ffrA:undetectable | 4o1zA-3ffrA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gff | IROE-LIKE SERINEHYDROLASE (Shewanellaoneidensis) |
PF00756(Esterase) | 5 | ILE A 76VAL A 78ILE A 120ALA A 125LEU A 132 | None | 0.79A | 4o1zA-3gffA:undetectable | 4o1zA-3gffA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gi8 | UNCHARACTERIZEDPROTEIN MJ0609 (Methanocaldococcusjannaschii) |
PF13520(AA_permease_2) | 5 | LEU C 162ILE C 276GLY C 279ALA C 280SER C 283 | None | 0.85A | 4o1zA-3gi8C:1.0 | 4o1zA-3gi8C:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjb | GLUCOSE-6-PHOSPHATEISOMERASE (Vibrio cholerae) |
PF00342(PGI) | 6 | ILE A 478LEU A 294TRP A 275ILE A 282GLY A 162LEU A 343 | None | 1.43A | 4o1zA-3hjbA:undetectable | 4o1zA-3hjbA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i6s | SUBTILISIN-LIKEPROTEASE (Solanumlycopersicum) |
PF00082(Peptidase_S8) | 6 | ILE A 374VAL A 373ILE A 466GLY A 441ALA A 421LEU A 419 | None | 1.46A | 4o1zA-3i6sA:undetectable | 4o1zA-3i6sA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2z | LEXA REPRESSOR (Thermotogamaritima) |
PF00717(Peptidase_S24)PF01726(LexA_DNA_bind) | 6 | ILE A 15VAL A 11ILE A 37GLY A 41ALA A 42LEU A 65 | None | 1.14A | 4o1zA-3k2zA:undetectable | 4o1zA-3k2zA:15.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khj | INOSINE-5-MONOPHOSPHATE DEHYDROGENASE (Cryptosporidiumparvum) |
PF00478(IMPDH) | 5 | ILE A 188ILE A 235GLY A 268ALA A 269LEU A 35 | None | 0.94A | 4o1zA-3khjA:undetectable | 4o1zA-3khjA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6y | CATENIN DELTA-1 (Homo sapiens) |
PF00514(Arm) | 5 | LEU A 666ILE A 682GLY A 680ALA A 681LEU A 583 | None | 0.98A | 4o1zA-3l6yA:0.9 | 4o1zA-3l6yA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lst | CALO1METHYLTRANSFERASE (Micromonosporaechinospora) |
PF00891(Methyltransf_2) | 5 | VAL A 247ILE A 339GLY A 177LEU A 206LEU A 200 | None | 0.98A | 4o1zA-3lstA:undetectable | 4o1zA-3lstA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lxu | TRIPEPTIDYL-PEPTIDASE 2 (Drosophilamelanogaster) |
PF00082(Peptidase_S8)PF12580(TPPII)PF12583(TPPII_N) | 6 | VAL X 367ILE X 40GLY X 470ALA X 473LEU X 475LEU X 524 | None | 1.41A | 4o1zA-3lxuX:0.0 | 4o1zA-3lxuX:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1l | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)REDUCTASE (Mycobacteriumtuberculosis) |
PF13561(adh_short_C2) | 5 | ILE A 444VAL A 388LEU A 345ILE A 229ALA A 425 | None | 0.92A | 4o1zA-3m1lA:undetectable | 4o1zA-3m1lA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mca | ELONGATION FACTOR 1ALPHA-LIKE PROTEIN (Schizosaccharomycespombe) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3) | 6 | ILE A 273VAL A 283LEU A 284LEU A 313LEU A 310LEU A 309 | None | 1.44A | 4o1zA-3mcaA:undetectable | 4o1zA-3mcaA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n2o | BIOSYNTHETICARGININEDECARBOXYLASE (Vibriovulnificus) |
PF02784(Orn_Arg_deC_N) | 5 | ILE A 81LEU A 74GLY A 549ALA A 350LEU A 296 | None | 0.97A | 4o1zA-3n2oA:undetectable | 4o1zA-3n2oA:20.79 |