SIMILAR PATTERNS OF AMINO ACIDS FOR 4O1Z_A_MXMA807

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)

(Escherichia
coli) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		6 VAL A 147
LEU A 150
GLY A 183
ALA A 182
LEU A 181
LEU A 131
 None
 1.39A 4o1zA-1b0aA:
0.0		 4o1zA-1b0aA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		6 MET A 241
ILE A 269
VAL A 325
LEU A 328
GLY A 343
LEU A 253
 None
 1.04A 4o1zA-1b25A:
0.0		 4o1zA-1b25A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 103
ILE A  37
GLY A  21
ALA A  17
LEU A  48
 None
 0.97A 4o1zA-1ebdA:
0.0		 4o1zA-1ebdA:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 ILE A 345
VAL A 349
LEU A 352
TRP A 387
GLY A 526
ALA A 527
LEU A 117
 None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
None
 1.29A 4o1zA-1ebvA:
62.2		 4o1zA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 MET A 113
ILE A 345
VAL A 349
LEU A 352
TRP A 387
ILE A 523
GLY A 526
ALA A 527
LEU A 534
LEU A 535
 None
None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 ( 3.3A)
None
 0.56A 4o1zA-1ebvA:
62.2		 4o1zA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 MET A 113
ILE A 523
GLY A 526
ALA A 527
LEU A 531
LEU A 534
LEU A 535
 None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
OAS  A 530 ( 3.3A)
None
 1.07A 4o1zA-1ebvA:
62.2		 4o1zA-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A 207
ALA A 206
SER A 109
LEU A 110
LEU A 106
 None
None
None
None
NAD  A 500 (-3.9A)
 0.92A 4o1zA-1evjA:
0.0		 4o1zA-1evjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		5 ILE A 182
ILE A   7
GLY A 293
ALA A 294
LEU A 298
 None
 0.84A 4o1zA-1evqA:
0.0		 4o1zA-1evqA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A  28
VAL A   5
GLY A  11
LEU A  19
LEU A  20
 None
None
FAD  A 448 (-3.7A)
None
None
 0.97A 4o1zA-1f8wA:
0.0		 4o1zA-1f8wA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A 259
ALA A 258
SER A 161
LEU A 162
LEU A 158
 None
None
None
None
NDP  A 500 (-4.1A)
 0.92A 4o1zA-1h6dA:
0.0		 4o1zA-1h6dA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7z ADENOVIRUS FIBRE
PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		6 MET A 230
ILE A 203
GLY A 136
LEU A 158
LEU A 210
LEU A 195
 None
 1.40A 4o1zA-1h7zA:
0.0		 4o1zA-1h7zA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E

(Trichoderma
reesei) 		PF01532
(Glyco_hydro_47) 		5 ILE A  66
GLY A 107
SER A 111
LEU A 115
LEU A 116
 None
 0.91A 4o1zA-1hcuA:
0.0		 4o1zA-1hcuA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icp 12-OXOPHYTODIENOATE
REDUCTASE 1

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		5 LEU A 326
GLY A  23
ALA A 271
LEU A 270
LEU A 265
 None
 0.93A 4o1zA-1icpA:
undetectable		 4o1zA-1icpA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j31 HYPOTHETICAL PROTEIN
PH0642

(Pyrococcus
horikoshii) 		PF00795
(CN_hydrolase) 		6 ILE A   7
VAL A  38
LEU A  37
GLY A 103
ALA A  76
LEU A  75
 None
 1.34A 4o1zA-1j31A:
undetectable		 4o1zA-1j31A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9l STATIONARY PHASE
SURVIVAL PROTEIN

(Thermotoga
maritima) 		PF01975
(SurE) 		5 ILE A 226
VAL A 224
GLY A 138
ALA A 139
LEU A 143
 None
 0.85A 4o1zA-1j9lA:
undetectable		 4o1zA-1j9lA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		5 GLY A 197
ALA A 198
SER A 201
LEU A 202
LEU A 205
 None
 0.71A 4o1zA-1jmyA:
undetectable		 4o1zA-1jmyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 ILE A 342
VAL A 346
ILE A  88
GLY A  51
LEU A 328
 None
 0.97A 4o1zA-1lq2A:
undetectable		 4o1zA-1lq2A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE

(Homo sapiens) 		PF02574
(S-methyl_trans) 		6 ILE A  13
GLY A 209
ALA A 210
SER A 211
LEU A  14
LEU A  17
 None
 1.24A 4o1zA-1lt8A:
undetectable		 4o1zA-1lt8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE

(Homo sapiens) 		PF02574
(S-methyl_trans) 		6 MET A 245
ILE A  13
GLY A 209
ALA A 210
LEU A  14
LEU A  17
 None
 1.41A 4o1zA-1lt8A:
undetectable		 4o1zA-1lt8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8b RIBOSE 5-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF06026
(Rib_5-P_isom_A) 		5 ILE A 189
VAL A 192
GLY A 196
LEU A 147
LEU A 150
 None
 0.95A 4o1zA-1o8bA:
undetectable		 4o1zA-1o8bA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og6 HYPOTHETICAL
OXIDOREDUCTASE YDHF

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		5 ILE A  80
ALA A 110
SER A 113
LEU A 114
LEU A 117
 None
 0.88A 4o1zA-1og6A:
undetectable		 4o1zA-1og6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		5 ILE A  82
ILE A  36
ALA A  30
LEU A  27
LEU A  56
 None
 0.89A 4o1zA-1px8A:
undetectable		 4o1zA-1px8A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 200
VAL A 177
LEU A 178
ILE A 369
LEU A 170
LEU A 260
 None
 1.23A 4o1zA-1s9iA:
undetectable		 4o1zA-1s9iA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 ILE A 387
ALA A 302
LEU A 306
LEU A 309
LEU A 311
 None
 0.96A 4o1zA-1serA:
undetectable		 4o1zA-1serA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sh8 HYPOTHETICAL PROTEIN
PA5026

(Pseudomonas
aeruginosa) 		PF14539
(DUF4442) 		5 GLY A  53
ALA A  54
LEU A  58
LEU A  61
LEU A  36
 None
 0.95A 4o1zA-1sh8A:
undetectable		 4o1zA-1sh8A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		6 ILE A 154
ILE A 411
GLY A 193
ALA A 159
SER A 190
LEU A 186
 None
 1.44A 4o1zA-1uc4A:
undetectable		 4o1zA-1uc4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		PF13476
(AAA_23)
no annotation 		5 ILE A 146
ILE B 839
ALA B 799
LEU B 800
LEU A 147
 None
 0.96A 4o1zA-1us8A:
undetectable		 4o1zA-1us8A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		6 ILE A 189
GLY A  86
ALA A  87
LEU A  91
LEU A  94
LEU A  95
 None
PLP  A 510 (-3.4A)
PLP  A 510 (-3.3A)
None
None
None
 1.42A 4o1zA-1v2dA:
undetectable		 4o1zA-1v2dA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		6 ILE A 189
GLY A 232
ALA A  87
LEU A  91
LEU A  94
LEU A  95
 None
None
PLP  A 510 (-3.3A)
None
None
None
 1.33A 4o1zA-1v2dA:
undetectable		 4o1zA-1v2dA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 ILE A 189
VAL A 217
GLY A  86
LEU A  94
LEU A  95
 None
None
PLP  A 510 (-3.4A)
None
None
 0.93A 4o1zA-1v2dA:
undetectable		 4o1zA-1v2dA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlm SAM-DEPENDENT
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		5 ILE A 100
GLY A 167
ALA A 166
LEU A 162
LEU A 159
 None
 0.99A 4o1zA-1vlmA:
undetectable		 4o1zA-1vlmA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		5 ILE A 636
GLY A 695
ALA A 696
LEU A 700
LEU A 703
 None
None
SO4  A2002 (-2.8A)
None
None
 0.85A 4o1zA-1vrqA:
undetectable		 4o1zA-1vrqA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		6 GLY A 413
ALA A  51
SER A  53
LEU A  54
LEU A  56
LEU A  57
 None
 1.44A 4o1zA-1w5dA:
undetectable		 4o1zA-1w5dA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu7 HISTIDYL-TRNA
SYNTHETASE

(Thermoplasma
acidophilum) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 ILE A 317
ALA A 145
LEU A 149
LEU A 152
LEU A 154
 None
 0.90A 4o1zA-1wu7A:
undetectable		 4o1zA-1wu7A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR

(Homo sapiens) 		PF01462
(LRRNT)
PF13306
(LRR_5) 		5 ILE C  77
LEU C 126
ILE C 151
LEU C 108
LEU C  83
 None
 0.95A 4o1zA-1xwdC:
undetectable		 4o1zA-1xwdC:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4k 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		6 ILE A   9
ILE A  18
ALA A 214
LEU A 218
LEU A 221
LEU A   4
 None
 1.48A 4o1zA-2a4kA:
undetectable		 4o1zA-2a4kA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A  97
ILE A  31
GLY A  15
ALA A  11
LEU A  42
 MPD  A 590 ( 4.6A)
None
None
None
None
 0.92A 4o1zA-2a8xA:
undetectable		 4o1zA-2a8xA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb6 TRANSCOBALAMIN II

(Bos taurus) 		PF01122
(Cobalamin_bind) 		6 ILE A 290
VAL A 287
GLY A 185
ALA A 187
SER A 189
LEU A 193
 None
 1.05A 4o1zA-2bb6A:
undetectable		 4o1zA-2bb6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0z VIRUS-LIKE PARTICLE

(Pyrococcus
furiosus) 		PF04454
(Linocin_M18) 		5 ILE A 250
LEU A 286
GLY A 127
SER A 129
LEU A 134
 None
 0.86A 4o1zA-2e0zA:
undetectable		 4o1zA-2e0zA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e44 INSULIN-LIKE GROWTH
FACTOR 2 MRNA
BINDING PROTEIN 3

(Homo sapiens) 		PF00076
(RRM_1) 		5 ILE A  85
VAL A 124
ALA A 132
LEU A 136
LEU A 139
 None
 0.96A 4o1zA-2e44A:
undetectable		 4o1zA-2e44A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A  15
VAL A  38
LEU A 115
GLY A 134
LEU A 281
 FAD  A8482 (-4.5A)
FAD  A8482 ( 4.8A)
None
None
FAD  A8482 (-4.7A)
 0.90A 4o1zA-2eq9A:
undetectable		 4o1zA-2eq9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		6 LEU A  20
ILE A  99
ALA A 103
LEU A 107
LEU A 110
LEU A  65
 None
 0.90A 4o1zA-2ftzA:
undetectable		 4o1zA-2ftzA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6l HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF03479
(DUF296) 		6 ILE A  51
VAL A  92
LEU A  75
GLY A  44
LEU A  70
LEU A  66
 None
 1.20A 4o1zA-2h6lA:
undetectable		 4o1zA-2h6lA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		6 VAL A 182
ILE A 250
ALA A 162
LEU A 164
LEU A 167
LEU A 227
 None
 1.27A 4o1zA-2i3aA:
undetectable		 4o1zA-2i3aA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1

(Anopheles
gambiae) 		PF00481
(PP2C) 		5 LEU A  61
ILE A 103
GLY A 179
LEU A 280
LEU A 188
 None
 0.99A 4o1zA-2irmA:
0.0		 4o1zA-2irmA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 161
LEU A 129
GLY A 208
ALA A 211
LEU A 150
LEU A 106
 None
 1.09A 4o1zA-2jc6A:
undetectable		 4o1zA-2jc6A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 161
VAL A 128
LEU A 129
GLY A 208
ALA A 211
LEU A 106
 None
 1.43A 4o1zA-2jc6A:
undetectable		 4o1zA-2jc6A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 ILE A 200
VAL A 199
GLY A 222
ALA A 223
LEU A 303
 None
 0.96A 4o1zA-2jg5A:
undetectable		 4o1zA-2jg5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgn ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00271
(Helicase_C) 		5 ILE A 493
VAL A 445
GLY A 452
ALA A 453
LEU A 460
 None
 0.89A 4o1zA-2jgnA:
undetectable		 4o1zA-2jgnA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbk KSHV PROTEASE

(Human
gammaherpesvirus
8) 		PF00716
(Peptidase_S21) 		6 ILE A  65
VAL A  11
LEU A 113
ILE A  42
GLY A  69
LEU A  34
 ACT  A 601 (-4.5A)
None
None
None
None
None
 1.17A 4o1zA-2pbkA:
undetectable		 4o1zA-2pbkA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis) 		PF00378
(ECH_1) 		5 ILE A  46
ALA A  21
SER A  24
LEU A  28
LEU A  29
 None
 0.96A 4o1zA-2pg8A:
undetectable		 4o1zA-2pg8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056

(Geobacillus
kaustophilus) 		PF08282
(Hydrolase_3) 		5 VAL A 222
GLY A 246
LEU A 251
LEU A 254
LEU A 256
 None
 0.89A 4o1zA-2pq0A:
undetectable		 4o1zA-2pq0A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qbu PRECORRIN-2
METHYLTRANSFERASE

(Methanothermobacter
thermautotrophicus) 		PF00590
(TP_methylase) 		5 ILE A  48
LEU A  53
ILE A  62
ALA A  34
LEU A 102
 None
 0.96A 4o1zA-2qbuA:
undetectable		 4o1zA-2qbuA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qio ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		5 ILE A  20
GLY A  23
SER A  27
LEU A  28
LEU A   4
 NAD  A 501 (-3.9A)
None
None
None
None
 0.90A 4o1zA-2qioA:
undetectable		 4o1zA-2qioA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpt EH DOMAIN-CONTAINING
PROTEIN-2

(Mus musculus) 		PF00350
(Dynamin_N)
PF12763
(EF-hand_4)
PF16880
(EHD_N) 		5 ILE A 151
VAL A  63
GLY A  70
LEU A  78
LEU A  79
 None
None
ANP  A 600 (-3.0A)
None
None
 0.97A 4o1zA-2qptA:
undetectable		 4o1zA-2qptA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		5 ILE A  78
ALA A 138
LEU A 139
LEU A  92
LEU A 106
 None
 0.92A 4o1zA-2qzpA:
undetectable		 4o1zA-2qzpA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1h HEMOGLOBIN SUBUNIT
BETA-4

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		5 ILE B 110
VAL B 114
LEU B 118
GLY B  13
LEU B  71
 None
 0.94A 4o1zA-2r1hB:
undetectable		 4o1zA-2r1hB:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 390
VAL A 402
GLY A 278
ALA A 279
LEU A 322
 None
 0.72A 4o1zA-2rjtA:
undetectable		 4o1zA-2rjtA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		5 ILE A 149
VAL A 137
LEU A 172
LEU A 166
LEU A 397
 None
 0.98A 4o1zA-2vfvA:
undetectable		 4o1zA-2vfvA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhe ACETYLTRANSFERASE

(Campylobacter
jejuni) 		PF00132
(Hexapep) 		5 GLY A 174
ALA A 175
LEU A 177
LEU A 160
LEU A 163
 None
 0.89A 4o1zA-2vheA:
undetectable		 4o1zA-2vheA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU B 161
ALA B 157
LEU B 156
LEU B 131
LEU B 128
 None
 0.94A 4o1zA-2w9fB:
undetectable		 4o1zA-2w9fB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdt UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE L3

(Plasmodium
falciparum) 		PF01088
(Peptidase_C12) 		6 ILE A  53
VAL A 167
LEU A 178
GLY A 102
LEU A  97
LEU A  17
 None
 1.27A 4o1zA-2wdtA:
undetectable		 4o1zA-2wdtA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 178
GLY A 174
ALA A 352
LEU A 353
LEU A 343
 None
 0.95A 4o1zA-2wgeA:
undetectable		 4o1zA-2wgeA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsb GALACTITOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		6 ILE A  88
VAL A  90
ILE A  23
ALA A 226
LEU A 230
LEU A   9
 None
None
NAD  A 500 (-3.9A)
None
None
None
 1.44A 4o1zA-2wsbA:
undetectable		 4o1zA-2wsbA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE

(Nocardia
farcinica) 		no annotation 5 GLY A 221
ALA A 222
LEU A 226
LEU A 229
LEU A 231
 None
 0.88A 4o1zA-2xecA:
undetectable		 4o1zA-2xecA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
BETA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF12838
(Fer4_7) 		5 VAL B 162
LEU B 166
GLY B  69
ALA B  70
LEU B  72
 None
 0.95A 4o1zA-2xsjB:
undetectable		 4o1zA-2xsjB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00034
(Cytochrom_C)
PF00116
(COX2)
PF02790
(COX2_TM) 		5 VAL B 149
ILE B 113
GLY B 115
ALA B 116
LEU B 135
 None
 0.96A 4o1zA-2yevB:
undetectable		 4o1zA-2yevB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeb SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL

(Sus scrofa) 		PF01127
(Sdh_cyt) 		5 ILE C  50
ALA C  54
SER C  57
LEU C  58
LEU C  61
 None
 0.93A 4o1zA-3aebC:
undetectable		 4o1zA-3aebC:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		5 ILE A 140
GLY A  65
ALA A 100
LEU A 103
LEU A 152
 None
 0.97A 4o1zA-3axxA:
undetectable		 4o1zA-3axxA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axy 14-3-3-LIKE PROTEIN
GF14-C

(Oryza sativa) 		PF00244
(14-3-3) 		5 ILE C  54
ILE C 185
ALA C 134
LEU C 133
LEU C  94
 None
 0.96A 4o1zA-3axyC:
undetectable		 4o1zA-3axyC:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		5 ILE A 256
GLY A 319
LEU A 321
LEU A 267
LEU A 280
 None
 0.96A 4o1zA-3azqA:
undetectable		 4o1zA-3azqA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9p CG5977-PA, ISOFORM A

(Drosophila
melanogaster) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 ILE A 473
ALA A 549
SER A 551
LEU A 552
LEU A 563
 None
 0.95A 4o1zA-3b9pA:
undetectable		 4o1zA-3b9pA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcz PROTEIN MEMO1

(Homo sapiens) 		PF01875
(Memo) 		5 ILE A  46
VAL A 186
LEU A  77
GLY A 170
LEU A 253
 None
 0.98A 4o1zA-3bczA:
undetectable		 4o1zA-3bczA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bio OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Porphyromonas
gingivalis) 		PF01408
(GFO_IDH_MocA)
PF16654
(DAPDH_C) 		5 ILE A  33
ILE A  87
ALA A  66
LEU A  25
LEU A  22
 None
 0.78A 4o1zA-3bioA:
undetectable		 4o1zA-3bioA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00196
(GerE) 		5 ILE A  63
VAL A  55
LEU A 188
LEU A 161
LEU A 158
 None
 0.94A 4o1zA-3c3wA:
undetectable		 4o1zA-3c3wA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6l TCR 2W20 ALPHA CHAIN

(Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		5 LEU A  45
ILE A  99
ALA A  90
LEU A  74
LEU A  20
 None
 0.95A 4o1zA-3c6lA:
undetectable		 4o1zA-3c6lA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE

(Escherichia
coli) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		5 ILE A 121
GLY A  72
ALA A  73
LEU A 104
LEU A  47
 None
 0.84A 4o1zA-3c8eA:
0.0		 4o1zA-3c8eA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cng NUDIX HYDROLASE

(Nitrosomonas
europaea) 		PF00293
(NUDIX)
PF14803
(Nudix_N_2) 		6 ILE A 146
ILE A  40
GLY A  70
ALA A  69
LEU A  67
LEU A  53
 None
GOL  A 501 (-4.8A)
NA  A 512 ( 4.2A)
None
None
None
 1.37A 4o1zA-3cngA:
undetectable		 4o1zA-3cngA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622

(Lactobacillus
plantarum) 		PF04263
(TPK_catalytic) 		5 ILE A  70
VAL A  72
ALA A  84
SER A  87
LEU A  92
 None
 0.88A 4o1zA-3cq9A:
undetectable		 4o1zA-3cq9A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkn PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Canis lupus) 		PF00344
(SecY) 		5 ILE A 210
ILE A 182
GLY A 185
ALA A 186
LEU A 193
 None
 0.91A 4o1zA-3dknA:
undetectable		 4o1zA-3dknA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkx REPLICATION PROTEIN
REPB

(Streptococcus
agalactiae) 		PF01719
(Rep_2) 		5 MET A  33
ILE A  75
VAL A  71
LEU A  84
LEU A  13
 None
 0.97A 4o1zA-3dkxA:
undetectable		 4o1zA-3dkxA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 274
LEU A 339
ILE A 399
ALA A 250
LEU A 290
 None
 0.98A 4o1zA-3dtcA:
undetectable		 4o1zA-3dtcA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 LEU A 964
GLY A 745
ALA A 747
SER A 749
LEU A 754
 None
 0.87A 4o1zA-3dy5A:
undetectable		 4o1zA-3dy5A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egc PUTATIVE RIBOSE
OPERON REPRESSOR

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		5 GLY A 259
ALA A 260
LEU A 264
LEU A 267
LEU A 269
 None
 0.91A 4o1zA-3egcA:
undetectable		 4o1zA-3egcA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3err FUSION PROTEIN OF
MICROTUBULE BINDING
DOMAIN FROM MOUSE
CYTOPLASMIC DYNEIN
AND SERYL-TRNA
SYNTHETASE FROM
THERMUS THERMOPHILUS

(Mus musculus;
Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF12777
(MT) 		5 ILE A 387
ALA A 302
LEU A 306
LEU A 309
LEU A 311
 None
 0.94A 4o1zA-3errA:
undetectable		 4o1zA-3errA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 173
LEU A 232
TRP A 289
ILE A 284
LEU A 182
 None
 0.89A 4o1zA-3f2aA:
undetectable		 4o1zA-3f2aA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB

(Escherichia
coli) 		PF04449
(Fimbrial_CS1)
PF07434
(CblD) 		5 ILE A 100
ILE A  94
GLY A  96
ALA A 135
LEU A 155
 None
 0.99A 4o1zA-3f83A:
undetectable		 4o1zA-3f83A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC

(Cytophaga
hutchinsonii) 		PF00266
(Aminotran_5) 		7 ILE A 202
VAL A 200
ILE A 248
GLY A 252
ALA A  47
LEU A  55
LEU A  57
 None
 1.22A 4o1zA-3ffrA:
undetectable		 4o1zA-3ffrA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gff IROE-LIKE SERINE
HYDROLASE

(Shewanella
oneidensis) 		PF00756
(Esterase) 		5 ILE A  76
VAL A  78
ILE A 120
ALA A 125
LEU A 132
 None
 0.79A 4o1zA-3gffA:
undetectable		 4o1zA-3gffA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		5 LEU C 162
ILE C 276
GLY C 279
ALA C 280
SER C 283
 None
 0.85A 4o1zA-3gi8C:
1.0		 4o1zA-3gi8C:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE

(Vibrio cholerae) 		PF00342
(PGI) 		6 ILE A 478
LEU A 294
TRP A 275
ILE A 282
GLY A 162
LEU A 343
 None
 1.43A 4o1zA-3hjbA:
undetectable		 4o1zA-3hjbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		6 ILE A 374
VAL A 373
ILE A 466
GLY A 441
ALA A 421
LEU A 419
 None
 1.46A 4o1zA-3i6sA:
undetectable		 4o1zA-3i6sA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2z LEXA REPRESSOR

(Thermotoga
maritima) 		PF00717
(Peptidase_S24)
PF01726
(LexA_DNA_bind) 		6 ILE A  15
VAL A  11
ILE A  37
GLY A  41
ALA A  42
LEU A  65
 None
 1.14A 4o1zA-3k2zA:
undetectable		 4o1zA-3k2zA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khj INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00478
(IMPDH) 		5 ILE A 188
ILE A 235
GLY A 268
ALA A 269
LEU A  35
 None
 0.94A 4o1zA-3khjA:
undetectable		 4o1zA-3khjA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6y CATENIN DELTA-1

(Homo sapiens) 		PF00514
(Arm) 		5 LEU A 666
ILE A 682
GLY A 680
ALA A 681
LEU A 583
 None
 0.98A 4o1zA-3l6yA:
0.9		 4o1zA-3l6yA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lst CALO1
METHYLTRANSFERASE

(Micromonospora
echinospora) 		PF00891
(Methyltransf_2) 		5 VAL A 247
ILE A 339
GLY A 177
LEU A 206
LEU A 200
 None
 0.98A 4o1zA-3lstA:
undetectable		 4o1zA-3lstA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		6 VAL X 367
ILE X  40
GLY X 470
ALA X 473
LEU X 475
LEU X 524
 None
 1.41A 4o1zA-3lxuX:
0.0		 4o1zA-3lxuX:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1l 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 ILE A 444
VAL A 388
LEU A 345
ILE A 229
ALA A 425
 None
 0.92A 4o1zA-3m1lA:
undetectable		 4o1zA-3m1lA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		6 ILE A 273
VAL A 283
LEU A 284
LEU A 313
LEU A 310
LEU A 309
 None
 1.44A 4o1zA-3mcaA:
undetectable		 4o1zA-3mcaA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF02784
(Orn_Arg_deC_N) 		5 ILE A  81
LEU A  74
GLY A 549
ALA A 350
LEU A 296
 None
 0.97A 4o1zA-3n2oA:
undetectable		 4o1zA-3n2oA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE

(Gadus morhua) 		PF00171
(Aldedh) 		4 VAL A  17
LEU A  49
LEU A 103
PHE A 188
 None
 1.05A 4o1zA-1a4sA:
0.0		 4o1zA-1a4sA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6g MYOGLOBIN

(Physeter
catodon) 		PF00042
(Globin) 		4 VAL A 114
LEU A 115
ARG A 118
LEU A  69
 None
 0.98A 4o1zA-1a6gA:
undetectable		 4o1zA-1a6gA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8u PROTEIN (MALATE
DEHYDROGENASE)

(Aquaspirillum
arcticum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A   8
LEU A  39
LEU A  21
PHE A 112
 None
 1.08A 4o1zA-1b8uA:
0.0		 4o1zA-1b8uA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		4 VAL A  93
LEU A  97
ARG A  96
LEU A  52
 None
 0.96A 4o1zA-1cg4A:
undetectable		 4o1zA-1cg4A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)

(Burkholderia
gladioli) 		PF00144
(Beta-lactamase) 		4 LEU A 131
LEU A 163
PHE A 219
MET A 277
 None
 1.07A 4o1zA-1ci9A:
0.0		 4o1zA-1ci9A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1civ NADP-MALATE
DEHYDROGENASE

(Flaveria
bidentis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A  45
LEU A  76
LEU A  58
PHE A 147
 None
 1.10A 4o1zA-1civA:
0.0		 4o1zA-1civA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 VAL A 116
LEU A 117
ARG A 120
LEU A 359
PHE A 518
MET A 522
 None
None
SCL  A 700 (-3.9A)
None
None
None
 0.49A 4o1zA-1ebvA:
62.2		 4o1zA-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 VAL A 335
LEU A 354
PHE A 180
MET A 156
 None
 1.13A 4o1zA-1g0dA:
0.0		 4o1zA-1g0dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
mutans) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 VAL A 227
LEU A 228
ARG A 230
LEU A 252
 None
 0.95A 4o1zA-1i74A:
0.0		 4o1zA-1i74A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
gordonii) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 VAL A 229
LEU A 230
ARG A 232
LEU A 254
 None
 0.70A 4o1zA-1k20A:
undetectable		 4o1zA-1k20A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldn L-LACTATE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A 215
LEU A 214
ARG A 212
LEU A 174
 None
 1.10A 4o1zA-1ldnA:
undetectable		 4o1zA-1ldnA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nuq FKSG76

(Homo sapiens) 		PF01467
(CTP_transf_like) 		4 VAL A  41
LEU A  33
ARG A  30
LEU A 133
 None
 1.00A 4o1zA-1nuqA:
undetectable		 4o1zA-1nuqA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4a PUR OPERON REPRESSOR

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF09182
(PuR_N) 		4 VAL A 114
LEU A 115
LEU A 232
PHE A 273
 None
 1.05A 4o1zA-1p4aA:
undetectable		 4o1zA-1p4aA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Pseudomonas
putida) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 VAL A 243
LEU A 242
LEU A 180
PHE A  19
 None
 0.99A 4o1zA-1re5A:
undetectable		 4o1zA-1re5A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5i C_TERMINAL DOMAIN OF
A PROBABLE
ATP-DEPENDENT RNA
HELICASE

(Homo sapiens) 		PF00271
(Helicase_C) 		4 VAL A 291
LEU A 341
LEU A 346
PHE A 381
 None
 0.97A 4o1zA-1t5iA:
undetectable		 4o1zA-1t5iA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		4 VAL A 282
LEU A 283
LEU A 234
PHE A 219
 None
 0.95A 4o1zA-1ua4A:
undetectable		 4o1zA-1ua4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens) 		PF00079
(Serpin) 		4 LEU I 362
LEU I 146
PHE I 108
MET I 103
 None
 1.05A 4o1zA-2b4xI:
undetectable		 4o1zA-2b4xI:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A

(Starkeya
novella) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 VAL A 152
LEU A 172
LEU A 136
PHE A  70
 None
 1.10A 4o1zA-2ca4A:
undetectable		 4o1zA-2ca4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9o DNAJ (HSP40)
HOMOLOG, SUBFAMILY
C, MEMBER 17

(Homo sapiens) 		PF00076
(RRM_1) 		4 VAL A 193
LEU A 194
ARG A 196
LEU A 237
 None
 0.96A 4o1zA-2d9oA:
undetectable		 4o1zA-2d9oA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2diw PUTATIVE RNA-BINDING
PROTEIN 16

(Homo sapiens) 		PF04818
(CTD_bind) 		4 VAL A 122
LEU A 123
LEU A 108
PHE A  16
 None
 0.92A 4o1zA-2diwA:
undetectable		 4o1zA-2diwA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN

(Aequorea
victoria;
Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin)
PF01353
(GFP) 		4 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
PIA  A  66 ( 4.9A)
 0.97A 4o1zA-2jadA:
undetectable		 4o1zA-2jadA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kt0 HOMEOBOX PROTEIN
NANOG

(Homo sapiens) 		PF00046
(Homeobox) 		4 VAL A  36
LEU A  37
ARG A  40
LEU A  59
 None
 0.82A 4o1zA-2kt0A:
undetectable		 4o1zA-2kt0A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 VAL A  93
LEU A  91
LEU A 187
PHE A  63
 None
 1.01A 4o1zA-2rjtA:
undetectable		 4o1zA-2rjtA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		4 VAL A 414
LEU A 413
LEU A 281
PHE A 300
 None
None
EDO  A1481 (-4.0A)
None
 1.11A 4o1zA-2vg8A:
undetectable		 4o1zA-2vg8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyo POLYSACCHARIDE
DEACETYLASE
DOMAIN-CONTAINING
PROTEIN ECU11_0510

(Encephalitozoon
cuniculi) 		PF01522
(Polysacc_deac_1) 		4 VAL A  53
LEU A  51
LEU A 195
PHE A  59
 None
 1.12A 4o1zA-2vyoA:
undetectable		 4o1zA-2vyoA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Homo sapiens) 		PF04869
(Uso1_p115_head) 		4 VAL A 509
LEU A 513
PHE A 613
MET A 496
 None
 1.07A 4o1zA-2w3cA:
undetectable		 4o1zA-2w3cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN

(Aequorea
victoria;
Mus musculus) 		PF00240
(ubiquitin)
PF01353
(GFP) 		4 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CR2  A  66 ( 4.3A)
 0.94A 4o1zA-3ai5A:
undetectable		 4o1zA-3ai5A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ako VENUS

(Plant
transformation
vector
pSITEII-4C1) 		PF01353
(GFP) 		4 VAL A  55
LEU A  53
LEU A 125
PHE B 165
 None
None
None
CR2  A  66 ( 4.5A)
 0.94A 4o1zA-3akoA:
undetectable		 4o1zA-3akoA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9j XANTHINE OXIDASE

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 VAL B 330
LEU B 334
LEU B 348
PHE B 390
 None
 0.93A 4o1zA-3b9jB:
undetectable		 4o1zA-3b9jB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		4 VAL A 364
LEU A 365
LEU A 466
PHE A 473
 None
 0.97A 4o1zA-3c6gA:
undetectable		 4o1zA-3c6gA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crn RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN, CHEY-LIKE

(Methanospirillum
hungatei) 		PF00072
(Response_reg) 		4 VAL A   7
LEU A   5
LEU A  38
PHE A  90
 None
 1.02A 4o1zA-3crnA:
undetectable		 4o1zA-3crnA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5t MALATE DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A   8
LEU A  39
LEU A  21
PHE A 110
 None
 1.07A 4o1zA-3d5tA:
undetectable		 4o1zA-3d5tA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dli METHYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF13489
(Methyltransf_23) 		4 VAL A 352
LEU A 355
LEU A 364
PHE A 280
 None
 0.87A 4o1zA-3dliA:
undetectable		 4o1zA-3dliA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evp GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		4 VAL A 213
LEU A 211
LEU A 283
PHE A  78
 None
None
None
CRO  A 224 ( 4.4A)
 0.95A 4o1zA-3evpA:
undetectable		 4o1zA-3evpA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 VAL A 213
LEU A 211
LEU A 283
PHE A  78
 None
None
None
CRO  A 224 ( 4.5A)
 0.93A 4o1zA-3evrA:
undetectable		 4o1zA-3evrA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq2 GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Bos taurus) 		PF04869
(Uso1_p115_head) 		4 VAL A 509
LEU A 513
PHE A 613
MET A 496
 None
 1.11A 4o1zA-3gq2A:
1.4		 4o1zA-3gq2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6p PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		4 VAL A 426
LEU A 423
LEU A 322
PHE A 447
 NA  A 601 (-4.6A)
None
None
None
 1.13A 4o1zA-3o6pA:
undetectable		 4o1zA-3o6pA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 VAL A 329
LEU A 327
LEU A 399
PHE A 194
 None
None
None
C12  A 340 ( 4.7A)
 0.95A 4o1zA-3osqA:
undetectable		 4o1zA-3osqA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		4 VAL A 467
LEU A 465
LEU A 537
PHE A 332
 None
None
None
C12  A 478 ( 4.5A)
 0.92A 4o1zA-3osrA:
undetectable		 4o1zA-3osrA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 VAL A 797
LEU A 794
LEU A 806
PHE A 709
 None
 0.86A 4o1zA-3pihA:
undetectable		 4o1zA-3pihA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		4 VAL A 461
ARG A 420
LEU A 430
PHE A   7
 None
 1.10A 4o1zA-3pt1A:
undetectable		 4o1zA-3pt1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qj4 RENALASE

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 VAL A   4
LEU A  28
LEU A 338
MET A  11
 None
 1.10A 4o1zA-3qj4A:
undetectable		 4o1zA-3qj4A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		4 VAL A 520
LEU A 524
LEU A 619
PHE A 406
 None
 1.12A 4o1zA-3thcA:
undetectable		 4o1zA-3thcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 VAL A 659
LEU A 707
LEU A 671
PHE A 490
 None
 0.88A 4o1zA-3wdjA:
undetectable		 4o1zA-3wdjA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		4 VAL A 834
LEU A 831
LEU A 843
PHE A 746
 None
 1.01A 4o1zA-3zqjA:
undetectable		 4o1zA-3zqjA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PDX2 PROTEIN

(Plasmodium
falciparum) 		PF01174
(SNO) 		4 VAL G  57
LEU G  11
LEU G  72
PHE G 209
 None
 1.12A 4o1zA-4adsG:
undetectable		 4o1zA-4adsG:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		4 VAL A1055
LEU A1053
LEU A1125
PHE A1165
 None
None
None
CR2  A1065 ( 4.2A)
 0.84A 4o1zA-4anjA:
undetectable		 4o1zA-4anjA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04054
(Not1) 		4 VAL A1601
LEU A1600
LEU A1612
PHE A1726
 None
 1.07A 4o1zA-4by6A:
undetectable		 4o1zA-4by6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3

(Homo sapiens) 		PF01825
(GPS)
PF02793
(HRM)
PF16489
(GAIN) 		4 VAL A 739
LEU A 803
LEU A 762
PHE A 646
 None
 1.12A 4o1zA-4dloA:
0.6		 4o1zA-4dloA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola) 		PF13354
(Beta-lactamase2) 		4 LEU A  90
LEU A 138
PHE A 211
MET A 208
 None
 0.84A 4o1zA-4ev4A:
undetectable		 4o1zA-4ev4A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 VAL A 593
LEU A 597
LEU A 565
PHE A 504
 None
 1.03A 4o1zA-4fddA:
1.8		 4o1zA-4fddA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1i MALATE DEHYDROGENASE

(Leishmania
major) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A   6
LEU A  37
LEU A  19
PHE A 108
 None
 1.04A 4o1zA-4i1iA:
undetectable		 4o1zA-4i1iA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 4 VAL A 296
LEU A 300
LEU A 336
PHE A 348
 None
None
PGE  A 502 (-4.7A)
EGR  A 501 ( 4.7A)
 1.09A 4o1zA-4j0kA:
undetectable		 4o1zA-4j0kA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7m PROTEIN DOM3Z

(Mus musculus) 		PF08652
(RAI1) 		4 VAL A 361
LEU A  29
LEU A 138
PHE A 373
 None
 0.77A 4o1zA-4j7mA:
undetectable		 4o1zA-4j7mA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrb GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Blattella
germanica) 		PF01353
(GFP)
PF06757
(Ins_allergen_rp) 		4 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CR2  A  66 ( 4.4A)
 1.01A 4o1zA-4jrbA:
undetectable		 4o1zA-4jrbA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k08 METHYL-ACCEPTING
CHEMOTAXIS SENSORY
TRANSDUCER

(Anaeromyxobacter
dehalogenans) 		PF17200
(sCache_2) 		4 VAL A  59
LEU A  58
LEU A  81
PHE A 130
 None
None
None
ACT  A 201 ( 4.8A)
 0.98A 4o1zA-4k08A:
undetectable		 4o1zA-4k08A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		4 VAL A 125
LEU A 126
LEU A 102
PHE A  23
 None
 0.92A 4o1zA-4kwgA:
undetectable		 4o1zA-4kwgA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,

(Aequorea
victoria;
Eimeria
acervulina) 		PF00046
(Homeobox)
PF01353
(GFP) 		4 VAL A 108
LEU A 106
LEU A 178
PHE A 218
 None
None
None
CR2  A 118 ( 4.9A)
 0.99A 4o1zA-4ndkA:
undetectable		 4o1zA-4ndkA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ok7 ENDOLYSIN

(Salmonella
virus SPN1S) 		PF00182
(Glyco_hydro_19) 		4 VAL A 144
LEU A 153
PHE A  42
MET A  28
 None
 1.08A 4o1zA-4ok7A:
undetectable		 4o1zA-4ok7A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		4 VAL A 842
LEU A 840
LEU A 912
PHE A 952
 None
None
None
CRO  A 853 ( 4.6A)
 0.88A 4o1zA-4p7hA:
undetectable		 4o1zA-4p7hA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pa1 INTEGRASE

(Feline
immunodeficiency
virus) 		PF00665
(rve) 		4 VAL A 103
LEU A 104
LEU A 132
MET A  60
 None
 0.97A 4o1zA-4pa1A:
undetectable		 4o1zA-4pa1A:
15.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 VAL A 117
LEU A 118
ARG A 121
LEU A 360
MET A 523
 BOG  A 604 (-3.9A)
None
BOG  A 604 ( 3.7A)
IBP  A 601 ( 4.7A)
None
 0.64A 4o1zA-4ph9A:
58.8		 4o1zA-4ph9A:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 VAL A 117
LEU A 118
LEU A 360
PHE A 519
MET A 523
 BOG  A 604 (-3.9A)
None
IBP  A 601 ( 4.7A)
None
None
 0.77A 4o1zA-4ph9A:
58.8		 4o1zA-4ph9A:
64.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 VAL A 455
LEU A  73
LEU A 772
MET A 194
 None
 1.06A 4o1zA-4q73A:
undetectable		 4o1zA-4q73A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qei GLYCINE--TRNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 LEU A 252
LEU A 135
PHE A 292
MET A 294
 None
None
AMP  A 701 (-3.6A)
AMP  A 701 (-3.2A)
 1.06A 4o1zA-4qeiA:
undetectable		 4o1zA-4qeiA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpa PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 VAL A 227
LEU A 228
ARG A 230
LEU A 252
 None
 0.93A 4o1zA-4rpaA:
undetectable		 4o1zA-4rpaA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rus FISH-EGG LECTIN

(Cyprinus carpio) 		PF06462
(Hyd_WA) 		4 LEU A  55
LEU A  78
PHE A 159
MET A 145
 None
1PE  A 305 (-4.4A)
None
None
 1.10A 4o1zA-4rusA:
undetectable		 4o1zA-4rusA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvo MALATE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A   9
LEU A  40
LEU A  22
PHE A 111
 None
 0.97A 4o1zA-4tvoA:
undetectable		 4o1zA-4tvoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uul L-LACTATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A   7
LEU A  37
LEU A  20
PHE A 108
 None
 1.04A 4o1zA-4uulA:
undetectable		 4o1zA-4uulA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uup MALATE DEHYDROGENASE

(synthetic
construct) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A   7
LEU A  37
LEU A  20
PHE A 108
 None
 0.91A 4o1zA-4uupA:
undetectable		 4o1zA-4uupA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Plasmodium
falciparum) 		PF01353
(GFP)
PF02861
(Clp_N) 		4 VAL A 204
LEU A 202
LEU A 274
PHE A 314
 None
None
None
CRO  A 215 ( 4.9A)
 1.00A 4o1zA-4xbiA:
1.3		 4o1zA-4xbiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgy GREEN FLUORESCENT
PROTEIN, MAB LCDR3,
GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Vibrio
parahaemolyticus;
synthetic
construct) 		PF01353
(GFP) 		4 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CRO  A  66 ( 4.0A)
 1.00A 4o1zA-4xgyA:
undetectable		 4o1zA-4xgyA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu4 HEMOGLOBIN

(Helogale
parvula) 		PF00042
(Globin) 		4 VAL B 137
LEU B  81
LEU B  75
PHE B 122
 None
 1.12A 4o1zA-4yu4B:
undetectable		 4o1zA-4yu4B:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0v 2',5'-PHOSPHODIESTER
ASE 12

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 VAL A 428
LEU A 429
LEU A 414
PHE A 493
 None
None
GOL  A 707 ( 4.0A)
None
 1.06A 4o1zA-4z0vA:
undetectable		 4o1zA-4z0vA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1

(Aequorea
victoria;
Homo sapiens) 		PF01353
(GFP) 		4 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CR2  A  66 ( 4.1A)
 0.93A 4o1zA-4z4mA:
undetectable		 4o1zA-4z4mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zf4 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		4 VAL A   5
LEU A   3
LEU A  75
PHE A 115
 None
None
None
4NT  A  15 ( 4.2A)
 0.90A 4o1zA-4zf4A:
undetectable		 4o1zA-4zf4A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ch6 FRIGIDA

(Vitis vinifera) 		PF07899
(Frigida) 		4 VAL A 144
LEU A 140
LEU A 126
PHE A 244
 None
 1.10A 4o1zA-5ch6A:
undetectable		 4o1zA-5ch6A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 VAL B 531
LEU B 530
LEU B 465
PHE B 508
 None
 1.08A 4o1zA-5do8B:
undetectable		 4o1zA-5do8B:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewu MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF02514
(CobN-Mg_chel) 		4 VAL A1084
LEU A1030
LEU A1045
MET A1107
 None
 1.01A 4o1zA-5ewuA:
undetectable		 4o1zA-5ewuA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex8 CYTOCHROME P450

(Streptomyces
toyocaensis) 		PF00067
(p450) 		4 VAL A 249
LEU A 366
LEU A 387
MET A 273
 None
None
None
HEM  A 401 ( 4.9A)
 0.94A 4o1zA-5ex8A:
undetectable		 4o1zA-5ex8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgm ECF RNA POLYMERASE
SIGMA FACTOR SIGR

(Streptomyces
coelicolor) 		PF08281
(Sigma70_r4_2) 		4 VAL A 187
LEU A 191
ARG A 190
LEU A 165
 None
 0.88A 4o1zA-5fgmA:
undetectable		 4o1zA-5fgmA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D

(Aequorea
victoria;
Streptococcus
pyogenes) 		PF01353
(GFP)
PF13930
(Endonuclea_NS_2) 		4 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CR2  A  66 (-4.8A)
 0.95A 4o1zA-5fguA:
undetectable		 4o1zA-5fguA:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 VAL A 116
LEU A 117
ARG A 120
LEU A 359
PHE A 518
MET A 522
 None
None
ID8  A 601 ( 4.4A)
None
None
ID8  A 601 (-4.2A)
 0.79A 4o1zA-5ikrA:
58.8		 4o1zA-5ikrA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3n GREEN FLUORESCENT
PROTEIN,HSDR

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF12008
(EcoR124_C) 		4 VAL A  61
LEU A  59
LEU A 131
PHE A 171
 None
None
None
GYS  A  72 ( 4.5A)
 0.94A 4o1zA-5j3nA:
undetectable		 4o1zA-5j3nA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF12436
(USP7_ICP0_bdg) 		4 VAL A 401
LEU A 323
LEU A 528
PHE A 480
 None
 1.04A 4o1zA-5j7tA:
undetectable		 4o1zA-5j7tA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		4 VAL A 582
LEU A 580
ARG A 577
PHE A 534
 None
 0.96A 4o1zA-5jjhA:
undetectable		 4o1zA-5jjhA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF14533
(USP7_C2) 		4 VAL A 401
LEU A 323
LEU A 528
PHE A 480
 None
 1.00A 4o1zA-5jtvA:
undetectable		 4o1zA-5jtvA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens) 		PF04858
(TH1)
no annotation 		4 LEU A  61
LEU B 283
PHE B 227
MET B 230
 None
 0.96A 4o1zA-5l3xA:
undetectable		 4o1zA-5l3xA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, 18 KDA
SUBUNIT
MITOCHONDRIAL
COMPLEX I, B14
SUBUNIT

(Ovis aries) 		no annotation 4 VAL g  77
LEU g  80
ARG g  76
LEU c  22
 None
 1.11A 4o1zA-5lnkg:
undetectable		 4o1zA-5lnkg:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0o TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE

(Jeotgalicoccus
sp. ATCC 8456) 		PF00067
(p450) 		4 VAL A  16
LEU A  17
LEU A  41
PHE A  58
 None
 0.83A 4o1zA-5m0oA:
0.4		 4o1zA-5m0oA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mse GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		no annotation 4 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CRO  A  66 ( 4.4A)
 0.91A 4o1zA-5mseA:
undetectable		 4o1zA-5mseA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nge UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		no annotation 4 VAL A 401
LEU A 323
LEU A 528
PHE A 480
 None
 0.99A 4o1zA-5ngeA:
undetectable		 4o1zA-5ngeA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0h 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		4 LEU f 231
LEU f 255
PHE f 324
MET f 365
 None
 1.10A 4o1zA-5t0hf:
0.7		 4o1zA-5t0hf:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 VAL A 483
LEU A 482
LEU A 461
PHE A 419
 None
 1.01A 4o1zA-5t88A:
undetectable		 4o1zA-5t88A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujd SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNI

(Staphylococcus
pseudintermedius) 		no annotation 4 VAL A 214
LEU A 212
LEU A  10
MET A  64
 None
 1.06A 4o1zA-5ujdA:
undetectable		 4o1zA-5ujdA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme)
PF02793
(HRM) 		4 VAL A 396
LEU A 395
LEU A 358
MET A 231
 None
 1.03A 4o1zA-5xezA:
undetectable		 4o1zA-5xezA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv5 CONSERVED PROTEIN

(Methanosarcina
mazei) 		no annotation 4 VAL A 155
LEU A 153
LEU A 138
PHE A 197
 None
 1.05A 4o1zA-5xv5A:
undetectable		 4o1zA-5xv5A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7t GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria) 		no annotation 4 VAL A  85
LEU A  83
LEU A 155
PHE A 195
 None
None
None
GYS  A  96 ( 4.6A)
 0.90A 4o1zA-6b7tA:
undetectable		 4o1zA-6b7tA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bme TRUNCATED HEMOGLOBIN
4

(Chlamydomonas
reinhardtii) 		no annotation 5 VAL A 122
LEU A 125
LEU A 142
PHE A  65
MET A  56
 None
None
HEM  A 201 (-4.9A)
HEM  A 201 (-4.3A)
None
 1.50A 4o1zA-6bmeA:
undetectable		 4o1zA-6bmeA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fc3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A 185
LEU A 186
LEU A 165
PHE A  68
 None
 0.80A 4o1zA-6fc3A:
undetectable		 4o1zA-6fc3A:
12.26