SIMILAR PATTERNS OF AMINO ACIDS FOR 4O1E_A_C2FA3000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfv MONOCLONAL ANTIBODY
FV4155

(Mus musculus) 		PF07686
(V-set) 		3 LYS H  65
ASN H  87
ASP H  62
 None
 0.80A 4o1eA-1cfvH:
undetectable		 4o1eA-1cfvH:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 LYS A 309
ASN A 487
ASP A 318
 None
 0.75A 4o1eA-1e1tA:
undetectable		 4o1eA-1e1tA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex6 GUANYLATE KINASE

(Saccharomyces
cerevisiae) 		PF00625
(Guanylate_kin) 		3 LYS A 130
ASN A 144
ASP A 127
 None
 0.83A 4o1eA-1ex6A:
undetectable		 4o1eA-1ex6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exz STEM CELL FACTOR

(Homo sapiens) 		PF02404
(SCF) 		3 LYS A  78
ASN A  65
ASP A  14
 None
 0.74A 4o1eA-1exzA:
undetectable		 4o1eA-1exzA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		3 LYS A 249
ASN A  77
ASP A 247
 None
 0.80A 4o1eA-1hlgA:
undetectable		 4o1eA-1hlgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdl CYTOCHROME C2, ISO-2

(Rhodospirillum
centenum) 		PF00034
(Cytochrom_C) 		3 LYS A  81
ASN A  53
ASP A  85
 None
HEM  A 500 (-3.4A)
None
 0.88A 4o1eA-1jdlA:
undetectable		 4o1eA-1jdlA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knz NONSTRUCTURAL
RNA-BINDING PROTEIN
34

(Rotavirus A) 		PF01665
(Rota_NSP3) 		3 LYS A   7
ASN A  61
ASP A  71
 None
 0.90A 4o1eA-1knzA:
undetectable		 4o1eA-1knzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		3 LYS A 211
ASN A 278
ASP A 336
 None
 0.90A 4o1eA-1lfwA:
undetectable		 4o1eA-1lfwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcn PORCINE PANCREATIC
PROCOLIPASE B

(Sus scrofa) 		PF01114
(Colipase)
PF02740
(Colipase_C) 		3 LYS A  24
ASN A  19
ASP A  12
 None
 0.83A 4o1eA-1pcnA:
undetectable		 4o1eA-1pcnA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tve HOMOSERINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		3 LYS A 283
ASN A 182
ASP A 306
 None
 0.73A 4o1eA-1tveA:
undetectable		 4o1eA-1tveA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgj HYPOTHETICAL PROTEIN
PH0099

(Pyrococcus
horikoshii) 		PF02834
(LigT_PEase) 		3 LYS A  70
ASN A  96
ASP A 158
 None
 0.83A 4o1eA-1vgjA:
undetectable		 4o1eA-1vgjA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 LYS A 395
ASN A 341
ASP A 397
 None
 0.77A 4o1eA-1w99A:
undetectable		 4o1eA-1w99A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		3 LYS A 168
ASN A 123
ASP A 165
 None
 0.83A 4o1eA-1yi7A:
undetectable		 4o1eA-1yi7A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1j DNA REPAIR
ENDONUCLEASE XPF

(Homo sapiens) 		no annotation 3 LYS A 884
ASN A 851
ASP A 888
 None
 0.87A 4o1eA-2a1jA:
undetectable		 4o1eA-2a1jA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkm TRUNCATED HEMOGLOBIN
FROM GEOBACILLUS
STEAROTHERMOPHILUS

(Geobacillus
stearothermophilus) 		PF01152
(Bac_globin) 		3 LYS A  85
ASN A 124
ASP A  34
 None
 0.79A 4o1eA-2bkmA:
undetectable		 4o1eA-2bkmA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9e PERIDININ-CHLOROPHYL
L A PROTEIN

(Amphidinium
carterae) 		PF02429
(PCP) 		3 LYS A 143
ASN A  94
ASP A 140
 DGD  A1332 (-3.6A)
PID  A1331 (-3.9A)
DGD  A1332 ( 4.7A)
 0.57A 4o1eA-2c9eA:
undetectable		 4o1eA-2c9eA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izp PUTATIVE MEMBRANE
ANTIGEN

(Burkholderia
pseudomallei) 		PF06511
(IpaD) 		3 LYS A1181
ASN A1258
ASP A1183
 None
 0.69A 4o1eA-2izpA:
undetectable		 4o1eA-2izpA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j49 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF04494
(TFIID_NTD2) 		3 LYS A 160
ASN A 261
ASP A 164
 None
 0.85A 4o1eA-2j49A:
undetectable		 4o1eA-2j49A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kif O6-METHYLGUANINE-DNA
METHYLTRANSFERASE

(Vibrio
parahaemolyticus) 		PF01035
(DNA_binding_1) 		3 LYS A  75
ASN A  59
ASP A  72
 None
 0.88A 4o1eA-2kifA:
undetectable		 4o1eA-2kifA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktq PROTEIN (LARGE
FRAGMENT OF DNA
POLYMERASE I)

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF09281
(Taq-exonuc) 		3 LYS A 542
ASN A 583
ASP A 547
 None
 0.80A 4o1eA-2ktqA:
undetectable		 4o1eA-2ktqA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		3 LYS A 239
ASN A 225
ASP A 236
 None
 0.76A 4o1eA-2m56A:
undetectable		 4o1eA-2m56A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		3 LYS A 366
ASN A 318
ASP A 370
 None
 0.86A 4o1eA-2odpA:
undetectable		 4o1eA-2odpA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pth PEPTIDYL-TRNA
HYDROLASE

(Escherichia
coli) 		PF01195
(Pept_tRNA_hydro) 		3 LYS A 122
ASN A 128
ASP A 118
 None
 0.74A 4o1eA-2pthA:
undetectable		 4o1eA-2pthA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Caldanaerobacter
subterraneus) 		PF03009
(GDPD) 		3 LYS A  22
ASN A  27
ASP A 240
 None
 0.84A 4o1eA-2pz0A:
10.8		 4o1eA-2pz0A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfc PLCR PROTEIN

(Bacillus
thuringiensis) 		PF01381
(HTH_3) 		3 LYS A 172
ASN A 163
ASP A 209
 None
 0.85A 4o1eA-2qfcA:
undetectable		 4o1eA-2qfcA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF00620
(RhoGAP) 		3 LYS A 188
ASN A 294
ASP A 184
 LYS  A 188 ( 0.0A)
ASN  A 294 ( 0.6A)
ASP  A 184 ( 0.5A)
 0.79A 4o1eA-2qv2A:
undetectable		 4o1eA-2qv2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r87 PURP PROTEIN PF1517

(Pyrococcus
furiosus) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		3 LYS A 164
ASN A 169
ASP A 121
 None
 0.90A 4o1eA-2r87A:
undetectable		 4o1eA-2r87A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tpt THYMIDINE
PHOSPHORYLASE

(Escherichia
coli) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		3 LYS A 191
ASN A 229
ASP A  83
 None
 0.90A 4o1eA-2tptA:
undetectable		 4o1eA-2tptA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus) 		PF03583
(LIP) 		3 LYS A 382
ASN A 357
ASP A 386
 None
 0.85A 4o1eA-2veoA:
undetectable		 4o1eA-2veoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN

(Shigella
flexneri) 		PF00497
(SBP_bac_3) 		3 LYS A 267
ASN A 274
ASP A 264
 None
 0.62A 4o1eA-2vhaA:
undetectable		 4o1eA-2vhaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb7 PT26-6P

(Thermococcus
sp. 26-2) 		no annotation 3 LYS A 146
ASN A 621
ASP A 153
 None
 0.90A 4o1eA-2wb7A:
undetectable		 4o1eA-2wb7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akk CTKA

(Helicobacter
pylori) 		PF07804
(HipA_C) 		3 LYS A 279
ASN A 204
ASP A 284
 None
 0.85A 4o1eA-3akkA:
undetectable		 4o1eA-3akkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		3 LYS A 107
ASN A  82
ASP A 160
 None
 0.89A 4o1eA-3bmwA:
9.7		 4o1eA-3bmwA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		no annotation 3 LYS B1049
ASN B1040
ASP B1053
 None
 0.86A 4o1eA-3cqcB:
undetectable		 4o1eA-3cqcB:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae;
Homo sapiens) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 LYS A 643
ASN A 621
ASP A 640
 None
 0.82A 4o1eA-3fjoA:
undetectable		 4o1eA-3fjoA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gha DISULFIDE BOND
FORMATION PROTEIN D

(Bacillus
subtilis) 		PF13462
(Thioredoxin_4) 		3 LYS A 212
ASN A 198
ASP A  86
 None
 0.79A 4o1eA-3ghaA:
undetectable		 4o1eA-3ghaA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlz UNCHARACTERIZED
PROTEIN BT_1490

(Bacteroides
thetaiotaomicron) 		PF12712
(DUF3805)
PF12713
(DUF3806) 		3 LYS A 181
ASN A 256
ASP A 178
 None
 0.84A 4o1eA-3hlzA:
undetectable		 4o1eA-3hlzA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzb CARBOHYDRATE BINDING
PROTEIN

(Flavobacterium
johnsoniae) 		no annotation 3 LYS A   7
ASN A  68
ASP A  37
 None
None
CA  A 101 (-4.5A)
 0.90A 4o1eA-3hzbA:
undetectable		 4o1eA-3hzbA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4r NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		PF03177
(Nucleoporin_C) 		3 LYS B1049
ASN B1040
ASP B1053
 None
 0.70A 4o1eA-3i4rB:
undetectable		 4o1eA-3i4rB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jaz VIRAL STRUCTURAL
PROTEIN 5

(Cypovirus 1) 		no annotation 3 LYS D  47
ASN D 291
ASP D 151
 None
 0.49A 4o1eA-3jazD:
undetectable		 4o1eA-3jazD:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1i RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00638
(Ran_BP1) 		3 LYS B 104
ASN B 149
ASP B  97
 None
 0.85A 4o1eA-3m1iB:
undetectable		 4o1eA-3m1iB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p13 D-RIBOSE PYRANASE

(Staphylococcus
aureus) 		PF05025
(RbsD_FucU) 		3 LYS A 114
ASN A  29
ASP A  24
 None
 0.84A 4o1eA-3p13A:
undetectable		 4o1eA-3p13A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf7 BENZOYL-COA
OXYGENASE COMPONENT
B

(Azoarcus
evansii) 		no annotation 3 LYS A  68
ASN A 147
ASP A  47
 None
 0.79A 4o1eA-3pf7A:
undetectable		 4o1eA-3pf7A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 LYS A 773
ASN A 809
ASP A 775
 None
 0.81A 4o1eA-3psfA:
undetectable		 4o1eA-3psfA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS A 162
ASN A 215
ASP A 321
 None
 0.79A 4o1eA-3r11A:
11.3		 4o1eA-3r11A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sd7 PUTATIVE PHOSPHATASE

(Clostridioides
difficile) 		PF13419
(HAD_2) 		3 LYS A 111
ASN A 143
ASP A  13
 None
 0.84A 4o1eA-3sd7A:
undetectable		 4o1eA-3sd7A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE

(Rhizomucor
miehei) 		PF01764
(Lipase_3) 		3 LYS A 131
ASN A 168
ASP A 128
 None
 0.75A 4o1eA-3tglA:
undetectable		 4o1eA-3tglA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tov GLYCOSYL TRANSFERASE
FAMILY 9

(Veillonella
parvula) 		PF01075
(Glyco_transf_9) 		3 LYS A  64
ASN A  75
ASP A  43
 None
SO4  A 349 (-3.8A)
None
 0.84A 4o1eA-3tovA:
undetectable		 4o1eA-3tovA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaq LBPB B-LOBE

(Moraxella bovis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		3 LYS A 289
ASN A 328
ASP A 272
 None
 0.79A 4o1eA-3uaqA:
undetectable		 4o1eA-3uaqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zc7 ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VBHT

(Bartonella
schoenbuchensis) 		PF02661
(Fic) 		3 LYS A  62
ASN A 142
ASP A  58
 None
ATP  A 300 (-3.7A)
None
 0.82A 4o1eA-3zc7A:
undetectable		 4o1eA-3zc7A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 LYS B2187
ASN B2348
ASP B2343
 None
 0.76A 4o1eA-3zefB:
undetectable		 4o1eA-3zefB:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN

(Caenorhabditis
elegans) 		no annotation 3 LYS A 103
ASN A 109
ASP A 101
 None
 0.81A 4o1eA-3zheA:
undetectable		 4o1eA-3zheA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE

(Bacteroides
ovatus) 		PF03414
(Glyco_transf_6) 		3 LYS A  72
ASN A  95
ASP A  68
 None
 0.80A 4o1eA-4ayjA:
undetectable		 4o1eA-4ayjA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 LYS C 336
ASN C 349
ASP C 340
 None
 0.77A 4o1eA-4b3iC:
undetectable		 4o1eA-4b3iC:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf5 ALANINE RACEMASE

(Aeromonas
hydrophila) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 LYS A 407
ASN A  33
ASP A  47
 None
 0.89A 4o1eA-4bf5A:
8.2		 4o1eA-4bf5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 LYS A 918
ASN A 840
ASP A 832
 None
 0.80A 4o1eA-4c3hA:
undetectable		 4o1eA-4c3hA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8d LYSINE-SPECIFIC
DEMETHYLASE 3B

(Homo sapiens) 		PF02373
(JmjC) 		3 LYS A1458
ASN A1542
ASP A1442
 None
 0.71A 4o1eA-4c8dA:
undetectable		 4o1eA-4c8dA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3y LEGUMAIN

(Cricetulus
griseus) 		PF01650
(Peptidase_C13) 		3 LYS A 106
ASN A 117
ASP A  77
 None
 0.89A 4o1eA-4d3yA:
undetectable		 4o1eA-4d3yA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4de8 CPS2A

(Streptococcus
pneumoniae) 		PF02916
(DNA_PPF)
PF03816
(LytR_cpsA_psr) 		3 LYS A 152
ASN A 126
ASP A 158
 None
 0.75A 4o1eA-4de8A:
undetectable		 4o1eA-4de8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		3 LYS A 314
ASN A  17
ASP A  52
 None
 0.65A 4o1eA-4dxyA:
undetectable		 4o1eA-4dxyA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz4 AGMATINASE

(Burkholderia
thailandensis) 		PF00491
(Arginase) 		3 LYS A 316
ASN A 278
ASP A  44
 None
 0.86A 4o1eA-4dz4A:
undetectable		 4o1eA-4dz4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqo LMO0859 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		3 LYS A 332
ASN A  63
ASP A 329
 None
 0.81A 4o1eA-4gqoA:
undetectable		 4o1eA-4gqoA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0n NECROTIC ENTERITIS
TOXIN B

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		3 LYS A 113
ASN A 223
ASP A 280
 None
 0.86A 4o1eA-4i0nA:
undetectable		 4o1eA-4i0nA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		3 LYS A 106
ASN A  82
ASP A 159
 EDO  A 719 (-2.5A)
None
EDO  A 719 ( 3.7A)
 0.89A 4o1eA-4jclA:
9.0		 4o1eA-4jclA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		3 LYS A 103
ASN A  82
ASP A 150
 None
 0.83A 4o1eA-4jcmA:
9.2		 4o1eA-4jcmA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jer HEMOPHORE HASA

(Yersinia pestis) 		PF06438
(HasA) 		3 LYS A 148
ASN A  63
ASP A  31
 None
 0.77A 4o1eA-4jerA:
undetectable		 4o1eA-4jerA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 LYS A 308
ASN A 163
ASP A 282
 None
 0.83A 4o1eA-4lglA:
undetectable		 4o1eA-4lglA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn3 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		3 LYS A 142
ASN A  79
ASP A 137
 None
 0.81A 4o1eA-4nn3A:
undetectable		 4o1eA-4nn3A:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		3 LYS A   8
ASN A  97
ASP A 229
 C2F  A3000 (-2.7A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.7A)
 0.00A 4o1eA-4o1eA:
49.4		 4o1eA-4o1eA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C

(Zea mays) 		PF00171
(Aldedh) 		3 LYS A  23
ASN A 220
ASP A  32
 None
 0.83A 4o1eA-4pxlA:
undetectable		 4o1eA-4pxlA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz2 ZMALDH

(Zea mays) 		PF00171
(Aldedh) 		3 LYS A  37
ASN A 234
ASP A  46
 None
 0.86A 4o1eA-4pz2A:
undetectable		 4o1eA-4pz2A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6j LUCINE RICH REPEATS
DLRR_H

(synthetic
construct) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		3 LYS A  73
ASN A  90
ASP A  51
 None
 0.84A 4o1eA-4r6jA:
undetectable		 4o1eA-4r6jA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Chloroflexus
aurantiacus) 		PF13407
(Peripla_BP_4) 		3 LYS A 318
ASN A 367
ASP A 298
 BGC  A 402 (-2.9A)
None
BGC  A 402 (-2.7A)
 0.90A 4o1eA-4rxuA:
undetectable		 4o1eA-4rxuA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7t MINOR STRUCTURAL
PROTEIN 4
MINOR STRUCTURAL
PROTEIN 5

(Lactococcus
phage Tuc2009;
Lactococcus
phage Tuc2009) 		no annotation
no annotation 		3 LYS A 315
ASN B 252
ASP A 308
 None
 0.82A 4o1eA-5e7tA:
undetectable		 4o1eA-5e7tA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		3 LYS F 318
ASN F 292
ASP F 322
 None
 0.81A 4o1eA-5gjwF:
undetectable		 4o1eA-5gjwF:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs7 CHOLOYLGLYCINE
HYDROLASE

(Enterococcus
faecalis) 		PF02275
(CBAH) 		3 LYS A 281
ASN A  69
ASP A  11
 None
 0.76A 4o1eA-5gs7A:
undetectable		 4o1eA-5gs7A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0i ASPARAGINYL
ENDOPEPTIDASE

(Oldenlandia
affinis) 		PF01650
(Peptidase_C13) 		3 LYS A 129
ASN A 140
ASP A 100
 None
 0.77A 4o1eA-5h0iA:
undetectable		 4o1eA-5h0iA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h60 TRANSFERASE

(Escherichia
coli) 		no annotation 3 LYS A 162
ASN A 140
ASP A 166
 None
 0.84A 4o1eA-5h60A:
undetectable		 4o1eA-5h60A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htf FOLDASE PROTEIN PRSA
1

(Listeria
monocytogenes) 		PF13616
(Rotamase_3) 		3 LYS A 270
ASN A  50
ASP A 268
 None
 0.90A 4o1eA-5htfA:
undetectable		 4o1eA-5htfA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		3 LYS A 183
ASN A 243
ASP A  63
 None
 0.87A 4o1eA-5hw3A:
undetectable		 4o1eA-5hw3A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		3 LYS A  19
ASN A  84
ASP A  16
 None
 0.86A 4o1eA-5i3aA:
undetectable		 4o1eA-5i3aA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 3 LYS A 527
ASN A 549
ASP A 525
 None
 0.88A 4o1eA-5i5jA:
undetectable		 4o1eA-5i5jA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lub LEGUMAIN

(Homo sapiens) 		no annotation 3 LYS B 101
ASN B 112
ASP B  72
 None
 0.83A 4o1eA-5lubB:
undetectable		 4o1eA-5lubB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcs KINETOCHORE PROTEIN
NDC80

(Saccharomyces
cerevisiae) 		PF03801
(Ndc80_HEC) 		3 LYS A 137
ASN A 229
ASP A 142
 None
 0.76A 4o1eA-5tcsA:
undetectable		 4o1eA-5tcsA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		3 LYS A 234
ASN A 152
ASP A 243
 None
 0.82A 4o1eA-5uamA:
undetectable		 4o1eA-5uamA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens;
Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C)
PF13191
(AAA_16)
PF14630
(ORC5_C) 		3 LYS E 164
ASN E 168
ASP A 840
 None
 0.63A 4o1eA-5uj7E:
undetectable		 4o1eA-5uj7E:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens;
Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C)
PF13191
(AAA_16)
PF14630
(ORC5_C) 		3 LYS E 164
ASN E 168
ASP A 840
 None
 0.62A 4o1eA-5ujmE:
undetectable		 4o1eA-5ujmE:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi4 INTERLEUKIN-33
INTERLEUKIN-1
RECEPTOR-LIKE 1

(Mus musculus;
Mus musculus) 		PF15095
(IL33)
PF13895
(Ig_2) 		3 LYS A 177
ASN B 312
ASP A 175
 None
 0.87A 4o1eA-5vi4A:
undetectable		 4o1eA-5vi4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvo PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		3 LYS A 289
ASN A 315
ASP A 646
 None
 0.83A 4o1eA-5vvoA:
8.2		 4o1eA-5vvoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8u ORF1AB PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		3 LYS A  87
ASN A 110
ASP A 147
 MPD  A 405 (-3.1A)
None
MPD  A 405 ( 4.4A)
 0.86A 4o1eA-5w8uA:
undetectable		 4o1eA-5w8uA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjp CYCLOHEXADIENYL
DEHYDRATASE

(Candidatus
Pelagibacter
ubique) 		PF00497
(SBP_bac_3) 		3 LYS A 228
ASN A 237
ASP A 104
 None
 0.71A 4o1eA-5wjpA:
undetectable		 4o1eA-5wjpA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcb PROBABLE SURFACE
PROTEIN

(Clostridium
perfringens) 		no annotation 3 LYS A  40
ASN A 166
ASP A 130
 None
 0.70A 4o1eA-5xcbA:
undetectable		 4o1eA-5xcbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcc PROBABLE SURFACE
PROTEIN

(Clostridium
perfringens) 		no annotation 3 LYS A  40
ASN A 166
ASP A 130
 None
 0.77A 4o1eA-5xccA:
undetectable		 4o1eA-5xccA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgw ISOASPARTYL
DIPEPTIDASE

(Colwellia
psychrerythraea) 		no annotation 3 LYS A  25
ASN A  57
ASP A  39
 None
 0.66A 4o1eA-5xgwA:
5.8		 4o1eA-5xgwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES8

(Toxoplasma
gondii) 		PF01201
(Ribosomal_S8e) 		3 LYS I 203
ASN I  88
ASP I 200
 None
 0.80A 4o1eA-5xxuI:
undetectable		 4o1eA-5xxuI:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyk PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		no annotation 3 LYS E 176
ASN E 154
ASP E 180
 None
 0.81A 4o1eA-5xykE:
undetectable		 4o1eA-5xykE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 3 LYS 21234
ASN 2 911
ASP 21210
 None
 0.77A 4o1eA-5zvs2:
undetectable		 4o1eA-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		no annotation 3 LYS A  52
ASN A  39
ASP A  46
 None
 0.80A 4o1eA-6bacA:
undetectable		 4o1eA-6bacA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co9 PROBABLE
COA-TRANSFERASE
ALPHA SUBUNIT

(Rhodococcus
jostii) 		no annotation 3 LYS A  34
ASN A 238
ASP A  59
 None
 0.76A 4o1eA-6co9A:
undetectable		 4o1eA-6co9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dhi -

(-) 		no annotation 3 LYS A 118
ASN A 129
ASP A  89
 None
 0.68A 4o1eA-6dhiA:
undetectable		 4o1eA-6dhiA:
undetectable