SIMILAR PATTERNS OF AMINO ACIDS FOR 4O1E_A_C2FA3000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		5 ILE A 102
LEU A  98
GLY A 214
SER A 193
ILE A 211
 None
 0.99A 4o1eA-1aj8A:
undetectable		 4o1eA-1aj8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0t PYRUVATE KINASE

(Escherichia
coli) 		PF00224
(PK)
PF02887
(PK_C) 		5 GLU A 222
ILE A 203
LEU A 178
GLY A  69
ASN A 159
 None
 1.09A 4o1eA-1e0tA:
9.3		 4o1eA-1e0tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 ILE A 197
ILE A 149
GLY A 170
LYS A  95
ILE A 191
 None
 1.05A 4o1eA-1eovA:
undetectable		 4o1eA-1eovA:
20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		7 ASN A   9
ASP A  75
ILE A 120
ASP A 160
GLY A 196
SER A 198
ILE A 227
 None
 1.15A 4o1eA-1f6yA:
33.6		 4o1eA-1f6yA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		6 ASN A  45
ILE A 120
LEU A 122
ASP A 160
GLY A 196
ILE A 227
 None
 0.82A 4o1eA-1f6yA:
33.6		 4o1eA-1f6yA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		8 GLU A   6
ASN A   9
ASP A  75
ILE A 120
LEU A 122
ASP A 160
GLY A 196
ILE A 227
 None
 0.60A 4o1eA-1f6yA:
33.6		 4o1eA-1f6yA:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)

(Allochromatium
vinosum) 		no annotation 5 ILE C  53
ILE C 120
GLY C  19
ILE C  29
ASN C  10
 HEM  C 901 (-4.4A)
None
None
HEM  C 901 (-4.4A)
None
 1.05A 4o1eA-1fcdC:
undetectable		 4o1eA-1fcdC:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882

(Lophonetta
specularioides) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		5 ASN A 179
ILE A  70
ASP A 193
GLY A 254
ASN A 137
 None
 1.15A 4o1eA-1h8lA:
undetectable		 4o1eA-1h8lA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jih DNA POLYMERASE ETA

(Saccharomyces
cerevisiae) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 ILE A  10
ILE A 212
LEU A 183
ILE A 190
ASN A 198
 None
 1.18A 4o1eA-1jihA:
undetectable		 4o1eA-1jihA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		5 ILE A 277
ILE A 105
LEU A 101
GLY A 157
ILE A 185
 None
 0.85A 4o1eA-1jjiA:
undetectable		 4o1eA-1jjiA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		5 ILE A 277
ILE A 105
LEU A 101
GLY A 158
ILE A 185
 None
 1.11A 4o1eA-1jjiA:
undetectable		 4o1eA-1jjiA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 ILE A 377
ILE A 442
LEU A 497
GLY A 481
ILE A 413
 None
 1.12A 4o1eA-1n7rA:
undetectable		 4o1eA-1n7rA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		5 ILE A 158
ILE A 276
GLY A 215
SER A 193
ILE A 212
 None
 1.05A 4o1eA-1nhcA:
undetectable		 4o1eA-1nhcA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		5 ILE A 223
ILE A 243
LEU A 245
GLY A 344
SER A 347
 None
 0.96A 4o1eA-1q15A:
undetectable		 4o1eA-1q15A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ILE B 517
GLY B 737
SER B 731
ILE B 738
ASN B 639
 None
None
None
MCN  B4921 ( 4.5A)
None
 1.03A 4o1eA-1t3qB:
undetectable		 4o1eA-1t3qB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yll CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF05962
(HutD) 		5 ASN A 110
ILE A 112
ASP A 108
LEU A 101
GLY A  22
 None
 1.16A 4o1eA-1yllA:
undetectable		 4o1eA-1yllA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cda GLUCOSE
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		5 GLU A  67
ASN A  89
ILE A  45
LEU A  50
GLY A  40
 ZN  A1368 (-3.1A)
None
None
None
None
 1.08A 4o1eA-2cdaA:
undetectable		 4o1eA-2cdaA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		5 ILE A 497
ILE A 113
LEU A 109
GLY A 131
ASN A 429
 None
 1.16A 4o1eA-2hj0A:
undetectable		 4o1eA-2hj0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iod DIHYDROFLAVONOL
4-REDUCTASE

(Vitis vinifera) 		PF01370
(Epimerase) 		5 ILE A 188
LEU A 297
GLY A 249
ILE A 186
ASN A 182
 None
 1.15A 4o1eA-2iodA:
undetectable		 4o1eA-2iodA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuu DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		5 GLU A 534
ILE A 717
LEU A 456
GLY A 623
ILE A 624
 None
 1.07A 4o1eA-2iuuA:
undetectable		 4o1eA-2iuuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ki8 TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE,
SUBUNIT D (FWDD-2)

(Archaeoglobus
fulgidus) 		PF01568
(Molydop_binding) 		5 GLU A  27
ILE A  57
LEU A  65
ASP A  61
GLY A  94
 None
 1.19A 4o1eA-2ki8A:
undetectable		 4o1eA-2ki8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nm1 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 ASN A1000
ILE A 952
LEU A1044
GLY A 968
ASN A 990
 None
 1.09A 4o1eA-2nm1A:
undetectable		 4o1eA-2nm1A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 ASN A 999
ILE A 951
LEU A1043
GLY A 967
ASN A 989
 None
 1.10A 4o1eA-2np0A:
undetectable		 4o1eA-2np0A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ILE A 148
ILE A  86
LEU A  90
GLY A  15
ILE A  16
 None
 0.94A 4o1eA-2q1yA:
2.3		 4o1eA-2q1yA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		5 ILE A 356
ILE A 118
LEU A 119
GLY A 292
ILE A 291
 None
 1.20A 4o1eA-2r7mA:
undetectable		 4o1eA-2r7mA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ILE A 690
LEU A 702
GLY A 736
SER A 616
ILE A 681
 None
 1.20A 4o1eA-2v9yA:
undetectable		 4o1eA-2v9yA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpq ACETYL-COA
CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A 306
ILE A 208
LEU A 246
GLY A 255
ILE A 210
 None
 1.07A 4o1eA-2vpqA:
undetectable		 4o1eA-2vpqA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wz8 CELLULOSOME PROTEIN
DOCKERIN TYPE I

(Ruminiclostridium
thermocellum) 		PF03422
(CBM_6) 		5 ASN A  18
ILE A 146
LEU A 120
ILE A 144
ASN A 140
 None
 1.06A 4o1eA-2wz8A:
undetectable		 4o1eA-2wz8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xla SLL1785 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 5 ILE A  81
ILE A 133
LEU A 135
GLY A 112
ILE A 108
 None
 1.20A 4o1eA-2xlaA:
undetectable		 4o1eA-2xlaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xla SLL1785 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 5 ILE A  81
ILE A 133
LEU A 135
GLY A 113
ILE A 108
 None
 1.19A 4o1eA-2xlaA:
undetectable		 4o1eA-2xlaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xla SLL1785 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 5 ILE A  91
ILE A 133
LEU A 135
GLY A 113
ILE A 108
 None
 1.12A 4o1eA-2xlaA:
undetectable		 4o1eA-2xlaA:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		7 ASN A  10
ASP A  76
ILE A 121
ASP A 161
GLY A 197
SER A 199
ILE A 228
 C2F  A3000 ( 4.8A)
C2F  A3000 (-3.4A)
C2F  A3000 ( 4.2A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.6A)
GOL  A1270 ( 3.9A)
C2F  A3000 (-4.6A)
 1.09A 4o1eA-2ycjA:
35.3		 4o1eA-2ycjA:
36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		5 ASN A  46
ILE A 121
ASP A 161
GLY A 197
ILE A 228
 None
C2F  A3000 ( 4.2A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-4.6A)
 0.80A 4o1eA-2ycjA:
35.3		 4o1eA-2ycjA:
36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		8 GLU A   7
ASN A  10
ASP A  76
ILE A 121
LEU A 123
ASP A 161
GLY A 197
ILE A 228
 C2F  A3000 ( 4.1A)
C2F  A3000 ( 4.8A)
C2F  A3000 (-3.4A)
C2F  A3000 ( 4.2A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-3.6A)
C2F  A3000 (-4.6A)
 0.59A 4o1eA-2ycjA:
35.3		 4o1eA-2ycjA:
36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abi PUTATIVE
UNCHARACTERIZED
PROTEIN PH1688

(Pyrococcus
horikoshii) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 ILE A 346
ILE A 215
LEU A 220
GLY A 273
ILE A 130
 None
 1.20A 4o1eA-3abiA:
undetectable		 4o1eA-3abiA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		8 ASN A 323
ASP A 390
ILE A 435
LEU A 437
ASP A 473
GLY A 505
SER A 507
ILE A 536
 None
 1.15A 4o1eA-3bolA:
24.6		 4o1eA-3bolA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		5 ASN A 360
ILE A 435
ASP A 473
GLY A 505
ILE A 536
 None
 0.83A 4o1eA-3bolA:
24.6		 4o1eA-3bolA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		8 GLU A 320
ASN A 323
ASP A 390
ILE A 435
LEU A 437
ASP A 473
GLY A 505
ILE A 536
 None
 0.82A 4o1eA-3bolA:
24.6		 4o1eA-3bolA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqw PUTATIVE CAPSID
PROTEIN OF PROPHAGE

(Escherichia
coli) 		PF03864
(Phage_cap_E) 		5 ASN A  46
ILE A  47
GLY A 153
ILE A 156
ASN A 149
 None
 1.09A 4o1eA-3bqwA:
undetectable		 4o1eA-3bqwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1x SERINE
ACETYLTRANSFERASE

(Bacteroides
vulgatus) 		PF00132
(Hexapep) 		5 ILE A 272
ILE A 160
ASP A 133
GLY A 200
ILE A 199
 None
 1.16A 4o1eA-3f1xA:
undetectable		 4o1eA-3f1xA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fju CARBOXYPEPTIDASE A1
CARBOXYPEPTIDASE A
INHIBITOR

(Homo sapiens;
Ascaris suum) 		PF00246
(Peptidase_M14)
PF15270
(ACI44) 		5 ILE B  57
ILE A 255
ASP A 256
GLY A 207
ILE A 243
 None
 1.20A 4o1eA-3fjuB:
undetectable		 4o1eA-3fjuB:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ge6 NITROREDUCTASE

(Exiguobacterium
sibiricum) 		PF00881
(Nitroreductase) 		5 ILE A  36
LEU A 148
SER A  80
ILE A  28
ASN A  25
 None
 1.09A 4o1eA-3ge6A:
undetectable		 4o1eA-3ge6A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h14 AMINOTRANSFERASE,
CLASSES I AND II

(Ruegeria
pomeroyi) 		PF00155
(Aminotran_1_2) 		5 ILE A  77
ILE A 198
LEU A 111
GLY A 103
ILE A 225
 None
 0.94A 4o1eA-3h14A:
undetectable		 4o1eA-3h14A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 ILE A 136
ILE A  16
LEU A  91
GLY A  95
ILE A 121
ASN A 102
 None
ANP  A 329 ( 4.2A)
ANP  A 329 ( 4.7A)
None
None
None
 1.39A 4o1eA-3hkoA:
undetectable		 4o1eA-3hkoA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzh CHEMOTAXIS OPERON
PROTEIN (CHEX)

(Borreliella
burgdorferi) 		PF13690
(CheX) 		6 ILE B 140
ILE B   3
LEU B 109
GLY B  55
ILE B 157
ASN B 133
 None
 1.11A 4o1eA-3hzhB:
undetectable		 4o1eA-3hzhB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		6 GLU A 358
ASN A 361
ASP A 431
ASP A 519
GLY A 558
ILE A 593
 THH  A 642 ( 3.5A)
GOL  A 643 (-3.1A)
THH  A 642 (-3.3A)
THH  A 642 (-3.4A)
THH  A 642 (-3.3A)
THH  A 642 (-4.2A)
 0.59A 4o1eA-3k13A:
27.8		 4o1eA-3k13A:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khy PROPIONATE KINASE

(Francisella
tularensis) 		PF00871
(Acetate_kinase) 		5 ILE A 245
ILE A 295
LEU A 291
GLY A 268
ASN A 258
 None
 0.97A 4o1eA-3khyA:
undetectable		 4o1eA-3khyA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 5 ILE B 138
LEU B  26
GLY B 196
SER B 159
ILE B 199
 None
None
None
PEO  B 322 (-3.1A)
None
 1.16A 4o1eA-3n3bB:
undetectable		 4o1eA-3n3bB:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		5 ILE A 313
ILE A 474
LEU A 475
GLY A 425
ILE A 417
 None
 1.15A 4o1eA-3odmA:
10.8		 4o1eA-3odmA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7m MALATE DEHYDROGENASE

(Francisella
tularensis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A   6
LEU A 247
GLY A 239
ILE A  76
ASN A 121
 None
 1.08A 4o1eA-3p7mA:
undetectable		 4o1eA-3p7mA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz4 ENDO-1,4-BETA-XYLANA
SE D

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		5 ILE A 196
LEU A 189
GLY A 132
ILE A 131
ASN A  98
 None
 1.13A 4o1eA-3qz4A:
undetectable		 4o1eA-3qz4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsj BONT/F

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 ASN A 869
ILE A 866
ASP A1069
ILE A 925
GLY A 886
 None
 1.12A 4o1eA-3rsjA:
undetectable		 4o1eA-3rsjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf6 LMO1369 PROTEIN

(Listeria
monocytogenes) 		PF01515
(PTA_PTB) 		5 ILE A 196
ILE A 119
LEU A 281
GLY A 160
ILE A 161
 None
 1.16A 4o1eA-3uf6A:
undetectable		 4o1eA-3uf6A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE

(Escherichia
coli) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 ILE A 381
ILE A 270
LEU A 265
GLY A 474
ILE A 470
 ILE  A 381 ( 0.6A)
ILE  A 270 ( 0.7A)
LEU  A 265 ( 0.6A)
GLY  A 474 ( 0.0A)
ILE  A 470 ( 0.6A)
 1.10A 4o1eA-3ulkA:
undetectable		 4o1eA-3ulkA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		5 ILE A 118
ILE A 174
LEU A 180
ILE A 149
ASN A 187
 None
 1.13A 4o1eA-4aeeA:
9.3		 4o1eA-4aeeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		7 GLU A 376
ASN A 379
ASP A 449
ASP A 537
GLY A 576
ILE A 611
ASN A 616
 THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.4A)
THG  A1652 (-3.4A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
None
 1.08A 4o1eA-4cczA:
28.3		 4o1eA-4cczA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddd IMMUNOGENIC PROTEIN

(Ehrlichia
chaffeensis) 		PF16868
(NMT1_3) 		5 GLU A  30
ILE A  34
LEU A 262
SER A 269
ILE A  32
 None
 1.15A 4o1eA-4dddA:
undetectable		 4o1eA-4dddA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ILE A 148
ILE A  86
LEU A  90
GLY A  15
ILE A  16
 None
 0.84A 4o1eA-4e6eA:
4.7		 4o1eA-4e6eA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 GLOMULIN

(Homo sapiens) 		PF08568
(Kinetochor_Ybp2) 		5 GLU E  38
ILE E  89
LEU E  93
GLY E  33
ILE E  37
 None
 0.91A 4o1eA-4f52E:
undetectable		 4o1eA-4f52E:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ILE A 666
LEU A 670
GLY A 677
SER A 711
ASN A 735
 ILE  A 666 ( 0.7A)
LEU  A 670 ( 0.5A)
GLY  A 677 ( 0.0A)
SER  A 711 ( 0.0A)
ASN  A 735 ( 0.6A)
 1.20A 4o1eA-4flxA:
undetectable		 4o1eA-4flxA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ILE A 702
ILE A 666
LEU A 670
GLY A 677
ASN A 735
 ILE  A 702 ( 0.7A)
ILE  A 666 ( 0.7A)
LEU  A 670 ( 0.5A)
GLY  A 677 ( 0.0A)
ASN  A 735 ( 0.6A)
 1.09A 4o1eA-4flxA:
undetectable		 4o1eA-4flxA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		5 GLU M 736
ASN M 737
ILE M 848
LEU M 844
GLY M 833
 None
 0.99A 4o1eA-4gq2M:
undetectable		 4o1eA-4gq2M:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSB

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		5 GLU B 171
ILE B  62
ILE B 259
GLY B 226
ILE B 229
 None
 1.16A 4o1eA-4hdsB:
undetectable		 4o1eA-4hdsB:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ija XYLR PROTEIN

(Staphylococcus
aureus) 		PF00480
(ROK)
PF01047
(MarR) 		5 GLU A 179
ILE A 229
LEU A 302
GLY A 211
SER A 183
 PO4  A 501 (-3.8A)
GOL  A 502 (-4.0A)
GOL  A 502 (-4.6A)
K  A 507 ( 4.3A)
None
 1.17A 4o1eA-4ijaA:
undetectable		 4o1eA-4ijaA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2

(Sulfolobus
solfataricus) 		PF10040
(CRISPR_Cas6) 		5 ILE A  31
ILE A  12
LEU A  14
GLY A 101
ILE A 112
 None
 1.20A 4o1eA-4ilrA:
undetectable		 4o1eA-4ilrA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC

(Rattus
norvegicus) 		no annotation 5 ILE E 309
ILE E  16
LEU E  15
GLY E  19
ILE E  18
 None
None
None
FAD  E 505 (-3.2A)
FAD  E 505 (-4.9A)
 1.18A 4o1eA-4kprE:
undetectable		 4o1eA-4kprE:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		5 ILE A 188
ILE A 155
LEU A  10
GLY A 135
ILE A 134
 None
 1.20A 4o1eA-4l6uA:
undetectable		 4o1eA-4l6uA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7z HPCH/HPAI ALDOLASE

(Chloroflexus
aurantiacus) 		PF03328
(HpcH_HpaI) 		5 ILE A 108
ILE A 130
ASP A 129
ILE A 121
ASN A  58
 None
 1.16A 4o1eA-4l7zA:
12.4		 4o1eA-4l7zA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfitobacterium
hafniense) 		PF13458
(Peripla_BP_6) 		6 ASN A 119
ILE A 120
ILE A  10
LEU A  45
ILE A  76
ASN A  80
 None
None
None
None
None
SO4  A 402 (-4.6A)
 1.33A 4o1eA-4mlcA:
undetectable		 4o1eA-4mlcA:
24.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		7 ASN A  10
ILE A  13
ASP A  44
ILE A 121
ASP A 161
GLY A 196
SER A 198
 C2F  A3000 ( 4.5A)
C2F  A3000 ( 4.4A)
None
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
 1.31A 4o1eA-4o1eA:
49.4		 4o1eA-4o1eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		12 GLU A   7
ASN A  10
ILE A  13
ASP A  76
ILE A 121
LEU A 123
ASP A 161
GLY A 196
SER A 198
LYS A 208
ILE A 227
ASN A 232
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
C2F  A3000 ( 4.4A)
C2F  A3000 (-3.6A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
C2F  A3000 (-3.8A)
C2F  A3000 (-4.3A)
C2F  A3000 (-4.0A)
 0.14A 4o1eA-4o1eA:
49.4		 4o1eA-4o1eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		6 GLU A   7
ASN A  10
ILE A  13
LEU A 163
ASP A 161
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 ( 4.5A)
C2F  A3000 ( 4.4A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 1.26A 4o1eA-4o1eA:
49.4		 4o1eA-4o1eA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		5 ILE A 356
LEU A 350
SER A 265
ILE A 361
ASN A 132
 None
 1.09A 4o1eA-4ohtA:
undetectable		 4o1eA-4ohtA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uft NUCLEOPROTEIN

(Measles
morbillivirus) 		PF00973
(Paramyxo_ncap) 		5 ILE B 223
ILE B  88
LEU B  87
GLY B  75
ILE B  74
 None
 1.03A 4o1eA-4uftB:
undetectable		 4o1eA-4uftB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 ILE A  51
LEU A 364
GLY A  61
ILE A 393
ASN A 429
 None
 1.14A 4o1eA-4v1yA:
5.9		 4o1eA-4v1yA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE

(Haemophilus
influenzae) 		PF00106
(adh_short) 		5 ILE A 166
ILE A 237
LEU A 223
GLY A 247
SER A 249
 NAD  A 301 (-3.9A)
None
None
None
None
 1.13A 4o1eA-4wuvA:
undetectable		 4o1eA-4wuvA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye9 GLUTAMINE--TRNA
LIGASE

(Homo sapiens) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2)
PF04558
(tRNA_synt_1c_R1) 		5 ILE A 499
ILE A 532
LEU A 325
GLY A 279
ILE A 278
 None
 1.05A 4o1eA-4ye9A:
undetectable		 4o1eA-4ye9A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbz URACIL-DNA
GLYCOSYLASE

(Sulfurisphaera
tokodaii) 		PF03167
(UDG) 		5 ILE A 140
ILE A 110
ASP A 107
ILE A 129
ASN A 136
 MES  A 202 ( 4.2A)
None
None
None
None
 1.12A 4o1eA-4zbzA:
undetectable		 4o1eA-4zbzA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF02775
(TPP_enzyme_C)
PF12367
(PFO_beta_C) 		5 ILE B  20
ASP B 171
ASP B 217
GLY B 253
ILE B 252
 None
 1.08A 4o1eA-5b48B:
2.4		 4o1eA-5b48B:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtb CG3822

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		5 ILE A  57
ILE A 241
LEU A 250
ILE A  47
ASN A  54
 None
 1.20A 4o1eA-5dtbA:
undetectable		 4o1eA-5dtbA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		5 GLU A 143
ILE A 534
GLY A 100
LYS A 123
ILE A  99
 None
 1.07A 4o1eA-5e84A:
undetectable		 4o1eA-5e84A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5glg FUMARATE REDUCTASE 2

(Saccharomyces
cerevisiae) 		PF00890
(FAD_binding_2) 		5 ILE A 188
LEU A 175
GLY A  71
SER A  74
ASN A 253
 None
None
None
FAD  A 602 (-2.6A)
FAD  A 602 (-4.6A)
 1.20A 4o1eA-5glgA:
undetectable		 4o1eA-5glgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxs SODIUM,CALCIUM
EXCHANGER

(Methanocaldococcus
jannaschii) 		PF01699
(Na_Ca_ex) 		5 GLU A 257
ASN A 258
ILE A 241
LEU A 131
ILE A  75
 None
 1.18A 4o1eA-5hxsA:
undetectable		 4o1eA-5hxsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikl GERANYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		5 ILE B 133
ILE B 119
GLY B  90
SER B  73
ILE B  93
 None
 1.13A 4o1eA-5iklB:
undetectable		 4o1eA-5iklB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		5 GLU A 319
ILE A 628
LEU A 620
GLY A 602
ILE A 601
 None
 0.95A 4o1eA-5ksdA:
undetectable		 4o1eA-5ksdA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ASN A 440
ILE A 417
LEU A 276
GLY A  19
ILE A  17
 None
 1.15A 4o1eA-5lnqA:
undetectable		 4o1eA-5lnqA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3x ANGIOTENSINOGEN

(Homo sapiens) 		no annotation 5 ASN A 393
ILE A 395
ILE A 128
LEU A 129
GLY A  81
 None
 1.02A 4o1eA-5m3xA:
undetectable		 4o1eA-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdm GLYCOPROTEIN

(Chandipura
vesiculovirus) 		no annotation 5 ILE E 360
LEU E 400
GLY E 392
ILE E 391
ASN E 375
 None
 1.14A 4o1eA-5mdmE:
undetectable		 4o1eA-5mdmE:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN ALPHA-1
CHAIN

(Schizosaccharomyces
pombe) 		no annotation 6 ASN E 232
ILE E 235
ILE E  79
ASP E  73
GLY E  10
SER E 144
 GTP  E 500 (-3.3A)
None
None
GTP  E 500 (-3.6A)
GTP  E 500 (-3.1A)
GTP  E 500 (-3.5A)
 1.40A 4o1eA-5mjsE:
undetectable		 4o1eA-5mjsE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4y SUSC HOMOLOG

(Bacteroides
thetaiotaomicron) 		no annotation 5 ILE D 299
LEU D 414
GLY D 376
ILE D 378
ASN D 999
 None
 0.96A 4o1eA-5t4yD:
undetectable		 4o1eA-5t4yD:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4y SUSC HOMOLOG

(Bacteroides
thetaiotaomicron) 		no annotation 5 ILE D1004
LEU D 414
GLY D 376
ILE D 378
ASN D 999
 None
 1.05A 4o1eA-5t4yD:
undetectable		 4o1eA-5t4yD:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 5 ASN A 376
ASP A 443
GLY A 570
SER A 572
ILE A 603
 NA  A3005 (-3.0A)
C2F  A3001 (-2.5A)
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-3.5A)
 1.16A 4o1eA-5vopA:
28.2		 4o1eA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 7 GLU A 373
ASN A 376
ASP A 443
LEU A 492
ASP A 531
GLY A 570
ILE A 603
 C2F  A3001 (-3.7A)
NA  A3005 (-3.0A)
C2F  A3001 (-2.5A)
None
C2F  A3001 (-2.5A)
C2F  A3001 (-3.5A)
C2F  A3001 (-3.5A)
 0.50A 4o1eA-5vopA:
28.2		 4o1eA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26

(Saccharomyces
cerevisiae) 		no annotation 5 ILE M 494
LEU M 308
GLY M 321
ILE M 319
ASN M 503
 None
 1.20A 4o1eA-5vvrM:
undetectable		 4o1eA-5vvrM:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE
NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus;
Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S)
PF10588
(NADH-G_4Fe-4S_3)
PF13459
(Fer4_15)
PF13510
(Fer2_4) 		5 ILE A 492
LEU B 155
GLY B 177
SER A 478
ILE B 178
 None
None
None
SF4  A 601 (-3.5A)
None
 1.20A 4o1eA-5xfaA:
undetectable		 4o1eA-5xfaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
epidermidis) 		no annotation 5 ILE A 212
ILE A 113
LEU A  59
ILE A  95
ASN A 153
 None
 1.14A 4o1eA-5yjjA:
undetectable		 4o1eA-5yjjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ck0 BIOTIN ACETYL
COENZYME A
CARBOXYLASE
SYNTHETASE

(Helicobacter
pylori) 		no annotation 5 ILE A 148
LEU A 139
GLY A 128
ILE A 127
ASN A 117
 None
None
F5D  A 301 (-3.5A)
None
None
 0.95A 4o1eA-6ck0A:
undetectable		 4o1eA-6ck0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 5 ILE X 334
ILE X 566
LEU X 223
ASP X 218
GLY X  88
 None
 1.16A 4o1eA-6elqX:
undetectable		 4o1eA-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ezn DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT WBP1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU G 126
GLY G 233
SER G 235
ILE G 232
ASN G 242
 None
 0.97A 4o1eA-6eznG:
undetectable		 4o1eA-6eznG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 5 ILE A 839
ILE A 867
GLY A 988
SER A 991
ASN A 720
 None
 1.10A 4o1eA-6fn1A:
undetectable		 4o1eA-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfv MONOCLONAL ANTIBODY
FV4155

(Mus musculus) 		PF07686
(V-set) 		3 LYS H  65
ASN H  87
ASP H  62
 None
 0.80A 4o1eA-1cfvH:
undetectable		 4o1eA-1cfvH:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 LYS A 309
ASN A 487
ASP A 318
 None
 0.75A 4o1eA-1e1tA:
undetectable		 4o1eA-1e1tA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex6 GUANYLATE KINASE

(Saccharomyces
cerevisiae) 		PF00625
(Guanylate_kin) 		3 LYS A 130
ASN A 144
ASP A 127
 None
 0.83A 4o1eA-1ex6A:
undetectable		 4o1eA-1ex6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exz STEM CELL FACTOR

(Homo sapiens) 		PF02404
(SCF) 		3 LYS A  78
ASN A  65
ASP A  14
 None
 0.74A 4o1eA-1exzA:
undetectable		 4o1eA-1exzA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		3 LYS A 249
ASN A  77
ASP A 247
 None
 0.80A 4o1eA-1hlgA:
undetectable		 4o1eA-1hlgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdl CYTOCHROME C2, ISO-2

(Rhodospirillum
centenum) 		PF00034
(Cytochrom_C) 		3 LYS A  81
ASN A  53
ASP A  85
 None
HEM  A 500 (-3.4A)
None
 0.88A 4o1eA-1jdlA:
undetectable		 4o1eA-1jdlA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knz NONSTRUCTURAL
RNA-BINDING PROTEIN
34

(Rotavirus A) 		PF01665
(Rota_NSP3) 		3 LYS A   7
ASN A  61
ASP A  71
 None
 0.90A 4o1eA-1knzA:
undetectable		 4o1eA-1knzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		3 LYS A 211
ASN A 278
ASP A 336
 None
 0.90A 4o1eA-1lfwA:
undetectable		 4o1eA-1lfwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcn PORCINE PANCREATIC
PROCOLIPASE B

(Sus scrofa) 		PF01114
(Colipase)
PF02740
(Colipase_C) 		3 LYS A  24
ASN A  19
ASP A  12
 None
 0.83A 4o1eA-1pcnA:
undetectable		 4o1eA-1pcnA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tve HOMOSERINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		3 LYS A 283
ASN A 182
ASP A 306
 None
 0.73A 4o1eA-1tveA:
undetectable		 4o1eA-1tveA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgj HYPOTHETICAL PROTEIN
PH0099

(Pyrococcus
horikoshii) 		PF02834
(LigT_PEase) 		3 LYS A  70
ASN A  96
ASP A 158
 None
 0.83A 4o1eA-1vgjA:
undetectable		 4o1eA-1vgjA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 LYS A 395
ASN A 341
ASP A 397
 None
 0.77A 4o1eA-1w99A:
undetectable		 4o1eA-1w99A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		3 LYS A 168
ASN A 123
ASP A 165
 None
 0.83A 4o1eA-1yi7A:
undetectable		 4o1eA-1yi7A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1j DNA REPAIR
ENDONUCLEASE XPF

(Homo sapiens) 		no annotation 3 LYS A 884
ASN A 851
ASP A 888
 None
 0.87A 4o1eA-2a1jA:
undetectable		 4o1eA-2a1jA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkm TRUNCATED HEMOGLOBIN
FROM GEOBACILLUS
STEAROTHERMOPHILUS

(Geobacillus
stearothermophilus) 		PF01152
(Bac_globin) 		3 LYS A  85
ASN A 124
ASP A  34
 None
 0.79A 4o1eA-2bkmA:
undetectable		 4o1eA-2bkmA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9e PERIDININ-CHLOROPHYL
L A PROTEIN

(Amphidinium
carterae) 		PF02429
(PCP) 		3 LYS A 143
ASN A  94
ASP A 140
 DGD  A1332 (-3.6A)
PID  A1331 (-3.9A)
DGD  A1332 ( 4.7A)
 0.57A 4o1eA-2c9eA:
undetectable		 4o1eA-2c9eA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izp PUTATIVE MEMBRANE
ANTIGEN

(Burkholderia
pseudomallei) 		PF06511
(IpaD) 		3 LYS A1181
ASN A1258
ASP A1183
 None
 0.69A 4o1eA-2izpA:
undetectable		 4o1eA-2izpA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j49 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF04494
(TFIID_NTD2) 		3 LYS A 160
ASN A 261
ASP A 164
 None
 0.85A 4o1eA-2j49A:
undetectable		 4o1eA-2j49A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kif O6-METHYLGUANINE-DNA
METHYLTRANSFERASE

(Vibrio
parahaemolyticus) 		PF01035
(DNA_binding_1) 		3 LYS A  75
ASN A  59
ASP A  72
 None
 0.88A 4o1eA-2kifA:
undetectable		 4o1eA-2kifA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktq PROTEIN (LARGE
FRAGMENT OF DNA
POLYMERASE I)

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF09281
(Taq-exonuc) 		3 LYS A 542
ASN A 583
ASP A 547
 None
 0.80A 4o1eA-2ktqA:
undetectable		 4o1eA-2ktqA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		3 LYS A 239
ASN A 225
ASP A 236
 None
 0.76A 4o1eA-2m56A:
undetectable		 4o1eA-2m56A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		3 LYS A 366
ASN A 318
ASP A 370
 None
 0.86A 4o1eA-2odpA:
undetectable		 4o1eA-2odpA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pth PEPTIDYL-TRNA
HYDROLASE

(Escherichia
coli) 		PF01195
(Pept_tRNA_hydro) 		3 LYS A 122
ASN A 128
ASP A 118
 None
 0.74A 4o1eA-2pthA:
undetectable		 4o1eA-2pthA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Caldanaerobacter
subterraneus) 		PF03009
(GDPD) 		3 LYS A  22
ASN A  27
ASP A 240
 None
 0.84A 4o1eA-2pz0A:
10.8		 4o1eA-2pz0A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfc PLCR PROTEIN

(Bacillus
thuringiensis) 		PF01381
(HTH_3) 		3 LYS A 172
ASN A 163
ASP A 209
 None
 0.85A 4o1eA-2qfcA:
undetectable		 4o1eA-2qfcA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF00620
(RhoGAP) 		3 LYS A 188
ASN A 294
ASP A 184
 LYS  A 188 ( 0.0A)
ASN  A 294 ( 0.6A)
ASP  A 184 ( 0.5A)
 0.79A 4o1eA-2qv2A:
undetectable		 4o1eA-2qv2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r87 PURP PROTEIN PF1517

(Pyrococcus
furiosus) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		3 LYS A 164
ASN A 169
ASP A 121
 None
 0.90A 4o1eA-2r87A:
undetectable		 4o1eA-2r87A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tpt THYMIDINE
PHOSPHORYLASE

(Escherichia
coli) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		3 LYS A 191
ASN A 229
ASP A  83
 None
 0.90A 4o1eA-2tptA:
undetectable		 4o1eA-2tptA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus) 		PF03583
(LIP) 		3 LYS A 382
ASN A 357
ASP A 386
 None
 0.85A 4o1eA-2veoA:
undetectable		 4o1eA-2veoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN

(Shigella
flexneri) 		PF00497
(SBP_bac_3) 		3 LYS A 267
ASN A 274
ASP A 264
 None
 0.62A 4o1eA-2vhaA:
undetectable		 4o1eA-2vhaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb7 PT26-6P

(Thermococcus
sp. 26-2) 		no annotation 3 LYS A 146
ASN A 621
ASP A 153
 None
 0.90A 4o1eA-2wb7A:
undetectable		 4o1eA-2wb7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akk CTKA

(Helicobacter
pylori) 		PF07804
(HipA_C) 		3 LYS A 279
ASN A 204
ASP A 284
 None
 0.85A 4o1eA-3akkA:
undetectable		 4o1eA-3akkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		3 LYS A 107
ASN A  82
ASP A 160
 None
 0.89A 4o1eA-3bmwA:
9.7		 4o1eA-3bmwA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		no annotation 3 LYS B1049
ASN B1040
ASP B1053
 None
 0.86A 4o1eA-3cqcB:
undetectable		 4o1eA-3cqcB:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae;
Homo sapiens) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 LYS A 643
ASN A 621
ASP A 640
 None
 0.82A 4o1eA-3fjoA:
undetectable		 4o1eA-3fjoA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gha DISULFIDE BOND
FORMATION PROTEIN D

(Bacillus
subtilis) 		PF13462
(Thioredoxin_4) 		3 LYS A 212
ASN A 198
ASP A  86
 None
 0.79A 4o1eA-3ghaA:
undetectable		 4o1eA-3ghaA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlz UNCHARACTERIZED
PROTEIN BT_1490

(Bacteroides
thetaiotaomicron) 		PF12712
(DUF3805)
PF12713
(DUF3806) 		3 LYS A 181
ASN A 256
ASP A 178
 None
 0.84A 4o1eA-3hlzA:
undetectable		 4o1eA-3hlzA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzb CARBOHYDRATE BINDING
PROTEIN

(Flavobacterium
johnsoniae) 		no annotation 3 LYS A   7
ASN A  68
ASP A  37
 None
None
CA  A 101 (-4.5A)
 0.90A 4o1eA-3hzbA:
undetectable		 4o1eA-3hzbA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4r NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		PF03177
(Nucleoporin_C) 		3 LYS B1049
ASN B1040
ASP B1053
 None
 0.70A 4o1eA-3i4rB:
undetectable		 4o1eA-3i4rB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jaz VIRAL STRUCTURAL
PROTEIN 5

(Cypovirus 1) 		no annotation 3 LYS D  47
ASN D 291
ASP D 151
 None
 0.49A 4o1eA-3jazD:
undetectable		 4o1eA-3jazD:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1i RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00638
(Ran_BP1) 		3 LYS B 104
ASN B 149
ASP B  97
 None
 0.85A 4o1eA-3m1iB:
undetectable		 4o1eA-3m1iB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p13 D-RIBOSE PYRANASE

(Staphylococcus
aureus) 		PF05025
(RbsD_FucU) 		3 LYS A 114
ASN A  29
ASP A  24
 None
 0.84A 4o1eA-3p13A:
undetectable		 4o1eA-3p13A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf7 BENZOYL-COA
OXYGENASE COMPONENT
B

(Azoarcus
evansii) 		no annotation 3 LYS A  68
ASN A 147
ASP A  47
 None
 0.79A 4o1eA-3pf7A:
undetectable		 4o1eA-3pf7A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 LYS A 773
ASN A 809
ASP A 775
 None
 0.81A 4o1eA-3psfA:
undetectable		 4o1eA-3psfA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS A 162
ASN A 215
ASP A 321
 None
 0.79A 4o1eA-3r11A:
11.3		 4o1eA-3r11A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sd7 PUTATIVE PHOSPHATASE

(Clostridioides
difficile) 		PF13419
(HAD_2) 		3 LYS A 111
ASN A 143
ASP A  13
 None
 0.84A 4o1eA-3sd7A:
undetectable		 4o1eA-3sd7A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE

(Rhizomucor
miehei) 		PF01764
(Lipase_3) 		3 LYS A 131
ASN A 168
ASP A 128
 None
 0.75A 4o1eA-3tglA:
undetectable		 4o1eA-3tglA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tov GLYCOSYL TRANSFERASE
FAMILY 9

(Veillonella
parvula) 		PF01075
(Glyco_transf_9) 		3 LYS A  64
ASN A  75
ASP A  43
 None
SO4  A 349 (-3.8A)
None
 0.84A 4o1eA-3tovA:
undetectable		 4o1eA-3tovA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaq LBPB B-LOBE

(Moraxella bovis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		3 LYS A 289
ASN A 328
ASP A 272
 None
 0.79A 4o1eA-3uaqA:
undetectable		 4o1eA-3uaqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zc7 ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VBHT

(Bartonella
schoenbuchensis) 		PF02661
(Fic) 		3 LYS A  62
ASN A 142
ASP A  58
 None
ATP  A 300 (-3.7A)
None
 0.82A 4o1eA-3zc7A:
undetectable		 4o1eA-3zc7A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 LYS B2187
ASN B2348
ASP B2343
 None
 0.76A 4o1eA-3zefB:
undetectable		 4o1eA-3zefB:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN

(Caenorhabditis
elegans) 		no annotation 3 LYS A 103
ASN A 109
ASP A 101
 None
 0.81A 4o1eA-3zheA:
undetectable		 4o1eA-3zheA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE

(Bacteroides
ovatus) 		PF03414
(Glyco_transf_6) 		3 LYS A  72
ASN A  95
ASP A  68
 None
 0.80A 4o1eA-4ayjA:
undetectable		 4o1eA-4ayjA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 LYS C 336
ASN C 349
ASP C 340
 None
 0.77A 4o1eA-4b3iC:
undetectable		 4o1eA-4b3iC:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf5 ALANINE RACEMASE

(Aeromonas
hydrophila) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 LYS A 407
ASN A  33
ASP A  47
 None
 0.89A 4o1eA-4bf5A:
8.2		 4o1eA-4bf5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 LYS A 918
ASN A 840
ASP A 832
 None
 0.80A 4o1eA-4c3hA:
undetectable		 4o1eA-4c3hA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8d LYSINE-SPECIFIC
DEMETHYLASE 3B

(Homo sapiens) 		PF02373
(JmjC) 		3 LYS A1458
ASN A1542
ASP A1442
 None
 0.71A 4o1eA-4c8dA:
undetectable		 4o1eA-4c8dA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3y LEGUMAIN

(Cricetulus
griseus) 		PF01650
(Peptidase_C13) 		3 LYS A 106
ASN A 117
ASP A  77
 None
 0.89A 4o1eA-4d3yA:
undetectable		 4o1eA-4d3yA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4de8 CPS2A

(Streptococcus
pneumoniae) 		PF02916
(DNA_PPF)
PF03816
(LytR_cpsA_psr) 		3 LYS A 152
ASN A 126
ASP A 158
 None
 0.75A 4o1eA-4de8A:
undetectable		 4o1eA-4de8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		3 LYS A 314
ASN A  17
ASP A  52
 None
 0.65A 4o1eA-4dxyA:
undetectable		 4o1eA-4dxyA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz4 AGMATINASE

(Burkholderia
thailandensis) 		PF00491
(Arginase) 		3 LYS A 316
ASN A 278
ASP A  44
 None
 0.86A 4o1eA-4dz4A:
undetectable		 4o1eA-4dz4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqo LMO0859 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		3 LYS A 332
ASN A  63
ASP A 329
 None
 0.81A 4o1eA-4gqoA:
undetectable		 4o1eA-4gqoA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0n NECROTIC ENTERITIS
TOXIN B

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		3 LYS A 113
ASN A 223
ASP A 280
 None
 0.86A 4o1eA-4i0nA:
undetectable		 4o1eA-4i0nA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		3 LYS A 106
ASN A  82
ASP A 159
 EDO  A 719 (-2.5A)
None
EDO  A 719 ( 3.7A)
 0.89A 4o1eA-4jclA:
9.0		 4o1eA-4jclA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		3 LYS A 103
ASN A  82
ASP A 150
 None
 0.83A 4o1eA-4jcmA:
9.2		 4o1eA-4jcmA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jer HEMOPHORE HASA

(Yersinia pestis) 		PF06438
(HasA) 		3 LYS A 148
ASN A  63
ASP A  31
 None
 0.77A 4o1eA-4jerA:
undetectable		 4o1eA-4jerA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 LYS A 308
ASN A 163
ASP A 282
 None
 0.83A 4o1eA-4lglA:
undetectable		 4o1eA-4lglA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn3 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		3 LYS A 142
ASN A  79
ASP A 137
 None
 0.81A 4o1eA-4nn3A:
undetectable		 4o1eA-4nn3A:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		3 LYS A   8
ASN A  97
ASP A 229
 C2F  A3000 (-2.7A)
C2F  A3000 (-3.0A)
C2F  A3000 (-3.7A)
 0.00A 4o1eA-4o1eA:
49.4		 4o1eA-4o1eA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C

(Zea mays) 		PF00171
(Aldedh) 		3 LYS A  23
ASN A 220
ASP A  32
 None
 0.83A 4o1eA-4pxlA:
undetectable		 4o1eA-4pxlA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz2 ZMALDH

(Zea mays) 		PF00171
(Aldedh) 		3 LYS A  37
ASN A 234
ASP A  46
 None
 0.86A 4o1eA-4pz2A:
undetectable		 4o1eA-4pz2A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6j LUCINE RICH REPEATS
DLRR_H

(synthetic
construct) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		3 LYS A  73
ASN A  90
ASP A  51
 None
 0.84A 4o1eA-4r6jA:
undetectable		 4o1eA-4r6jA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Chloroflexus
aurantiacus) 		PF13407
(Peripla_BP_4) 		3 LYS A 318
ASN A 367
ASP A 298
 BGC  A 402 (-2.9A)
None
BGC  A 402 (-2.7A)
 0.90A 4o1eA-4rxuA:
undetectable		 4o1eA-4rxuA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7t MINOR STRUCTURAL
PROTEIN 4
MINOR STRUCTURAL
PROTEIN 5

(Lactococcus
phage Tuc2009;
Lactococcus
phage Tuc2009) 		no annotation
no annotation 		3 LYS A 315
ASN B 252
ASP A 308
 None
 0.82A 4o1eA-5e7tA:
undetectable		 4o1eA-5e7tA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		3 LYS F 318
ASN F 292
ASP F 322
 None
 0.81A 4o1eA-5gjwF:
undetectable		 4o1eA-5gjwF:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs7 CHOLOYLGLYCINE
HYDROLASE

(Enterococcus
faecalis) 		PF02275
(CBAH) 		3 LYS A 281
ASN A  69
ASP A  11
 None
 0.76A 4o1eA-5gs7A:
undetectable		 4o1eA-5gs7A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0i ASPARAGINYL
ENDOPEPTIDASE

(Oldenlandia
affinis) 		PF01650
(Peptidase_C13) 		3 LYS A 129
ASN A 140
ASP A 100
 None
 0.77A 4o1eA-5h0iA:
undetectable		 4o1eA-5h0iA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h60 TRANSFERASE

(Escherichia
coli) 		no annotation 3 LYS A 162
ASN A 140
ASP A 166
 None
 0.84A 4o1eA-5h60A:
undetectable		 4o1eA-5h60A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htf FOLDASE PROTEIN PRSA
1

(Listeria
monocytogenes) 		PF13616
(Rotamase_3) 		3 LYS A 270
ASN A  50
ASP A 268
 None
 0.90A 4o1eA-5htfA:
undetectable		 4o1eA-5htfA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		3 LYS A 183
ASN A 243
ASP A  63
 None
 0.87A 4o1eA-5hw3A:
undetectable		 4o1eA-5hw3A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		3 LYS A  19
ASN A  84
ASP A  16
 None
 0.86A 4o1eA-5i3aA:
undetectable		 4o1eA-5i3aA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 3 LYS A 527
ASN A 549
ASP A 525
 None
 0.88A 4o1eA-5i5jA:
undetectable		 4o1eA-5i5jA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lub LEGUMAIN

(Homo sapiens) 		no annotation 3 LYS B 101
ASN B 112
ASP B  72
 None
 0.83A 4o1eA-5lubB:
undetectable		 4o1eA-5lubB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcs KINETOCHORE PROTEIN
NDC80

(Saccharomyces
cerevisiae) 		PF03801
(Ndc80_HEC) 		3 LYS A 137
ASN A 229
ASP A 142
 None
 0.76A 4o1eA-5tcsA:
undetectable		 4o1eA-5tcsA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		3 LYS A 234
ASN A 152
ASP A 243
 None
 0.82A 4o1eA-5uamA:
undetectable		 4o1eA-5uamA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens;
Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C)
PF13191
(AAA_16)
PF14630
(ORC5_C) 		3 LYS E 164
ASN E 168
ASP A 840
 None
 0.63A 4o1eA-5uj7E:
undetectable		 4o1eA-5uj7E:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens;
Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C)
PF13191
(AAA_16)
PF14630
(ORC5_C) 		3 LYS E 164
ASN E 168
ASP A 840
 None
 0.62A 4o1eA-5ujmE:
undetectable		 4o1eA-5ujmE:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi4 INTERLEUKIN-33
INTERLEUKIN-1
RECEPTOR-LIKE 1

(Mus musculus;
Mus musculus) 		PF15095
(IL33)
PF13895
(Ig_2) 		3 LYS A 177
ASN B 312
ASP A 175
 None
 0.87A 4o1eA-5vi4A:
undetectable		 4o1eA-5vi4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvo PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		3 LYS A 289
ASN A 315
ASP A 646
 None
 0.83A 4o1eA-5vvoA:
8.2		 4o1eA-5vvoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8u ORF1AB PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		3 LYS A  87
ASN A 110
ASP A 147
 MPD  A 405 (-3.1A)
None
MPD  A 405 ( 4.4A)
 0.86A 4o1eA-5w8uA:
undetectable		 4o1eA-5w8uA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjp CYCLOHEXADIENYL
DEHYDRATASE

(Candidatus
Pelagibacter
ubique) 		PF00497
(SBP_bac_3) 		3 LYS A 228
ASN A 237
ASP A 104
 None
 0.71A 4o1eA-5wjpA:
undetectable		 4o1eA-5wjpA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcb PROBABLE SURFACE
PROTEIN

(Clostridium
perfringens) 		no annotation 3 LYS A  40
ASN A 166
ASP A 130
 None
 0.70A 4o1eA-5xcbA:
undetectable		 4o1eA-5xcbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcc PROBABLE SURFACE
PROTEIN

(Clostridium
perfringens) 		no annotation 3 LYS A  40
ASN A 166
ASP A 130
 None
 0.77A 4o1eA-5xccA:
undetectable		 4o1eA-5xccA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgw ISOASPARTYL
DIPEPTIDASE

(Colwellia
psychrerythraea) 		no annotation 3 LYS A  25
ASN A  57
ASP A  39
 None
 0.66A 4o1eA-5xgwA:
5.8		 4o1eA-5xgwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES8

(Toxoplasma
gondii) 		PF01201
(Ribosomal_S8e) 		3 LYS I 203
ASN I  88
ASP I 200
 None
 0.80A 4o1eA-5xxuI:
undetectable		 4o1eA-5xxuI:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyk PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		no annotation 3 LYS E 176
ASN E 154
ASP E 180
 None
 0.81A 4o1eA-5xykE:
undetectable		 4o1eA-5xykE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 3 LYS 21234
ASN 2 911
ASP 21210
 None
 0.77A 4o1eA-5zvs2:
undetectable		 4o1eA-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		no annotation 3 LYS A  52
ASN A  39
ASP A  46
 None
 0.80A 4o1eA-6bacA:
undetectable		 4o1eA-6bacA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co9 PROBABLE
COA-TRANSFERASE
ALPHA SUBUNIT

(Rhodococcus
jostii) 		no annotation 3 LYS A  34
ASN A 238
ASP A  59
 None
 0.76A 4o1eA-6co9A:
undetectable		 4o1eA-6co9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dhi -

(-) 		no annotation 3 LYS A 118
ASN A 129
ASP A  89
 None
 0.68A 4o1eA-6dhiA:
undetectable		 4o1eA-6dhiA:
undetectable