SIMILAR PATTERNS OF AMINO ACIDS FOR 4O0S_A_ADNA500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 408
VAL A 416
ALA A 428
LYS A 430
ASN A 526
LEU A 528
ASP A 539
 None
 0.68A 4o0sA-1k2pA:
15.4		 4o0sA-1k2pA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 GLY A 202
VAL A 209
ALA A 220
LYS A 222
ASN A 319
LEU A 321
ASP A 332
 None
 0.94A 4o0sA-1k9aA:
26.5		 4o0sA-1k9aA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 GLY A 212
VAL A 219
ALA A 230
LYS A 232
LEU A 260
ASN A 338
LEU A 340
ASP A 351
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-4.2A)
None
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.62A 4o0sA-1py5A:
18.4		 4o0sA-1py5A:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 LEU A 164
GLY A 165
VAL A 172
ALA A 185
LEU A 226
ASN A 299
LEU A 301
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.4A)
MG  A 809 ( 3.0A)
ADP  A 810 (-4.7A)
 0.45A 4o0sA-1q8yA:
25.8		 4o0sA-1q8yA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  78
GLY A  79
VAL A  86
ALA A  99
LYS A 101
LEU A 201
ASP A 212
 ATP  A 535 (-3.9A)
ATP  A 535 ( 3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
ATP  A 535 (-4.8A)
MG  A 536 (-3.3A)
 0.98A 4o0sA-1s9iA:
25.4		 4o0sA-1s9iA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 370
VAL A 377
ALA A 389
LYS A 391
ASN A 487
LEU A 489
ASP A 500
 None
 0.91A 4o0sA-1snxA:
24.7		 4o0sA-1snxA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
GLY A 596
VAL A 603
ALA A 621
LYS A 623
ASN A 797
LEU A 799
 STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
None
STI  A   3 (-4.4A)
 0.67A 4o0sA-1t46A:
24.0		 4o0sA-1t46A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  16
VAL A  23
ALA A  36
LYS A  38
ASN A 135
LEU A 137
ASP A 148
 HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.82A 4o0sA-1zltA:
21.3		 4o0sA-1zltA:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
ASN A 135
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
 0.50A 4o0sA-1zltA:
21.3		 4o0sA-1zltA:
29.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LYS A  42
ASN A 144
ASP A 161
 None
None
None
GOL  A3001 (-3.5A)
None
None
None
 0.88A 4o0sA-2a2aA:
29.8		 4o0sA-2a2aA:
32.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
GLY X  18
VAL X  25
ALA X  37
ASN X 135
LEU X 137
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.9A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.77A 4o0sA-2dq7X:
27.9		 4o0sA-2dq7X:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
GLY X  18
VAL X  25
LYS X  39
ASN X 135
LEU X 137
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.9A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.89A 4o0sA-2dq7X:
27.9		 4o0sA-2dq7X:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 162
GLY A 163
VAL A 170
ALA A 184
LYS A 186
ASN A 288
ASP A 320
 None
 0.87A 4o0sA-2eu9A:
26.3		 4o0sA-2eu9A:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LYS A  42
ASN A 142
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
MG  A 600 ( 2.7A)
ADP  A 500 (-4.3A)
 0.83A 4o0sA-2f9gA:
27.1		 4o0sA-2f9gA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
GLY A 274
VAL A 281
ALA A 293
ASN A 391
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
None
 0.95A 4o0sA-2hckA:
25.2		 4o0sA-2hckA:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  55
GLY A  56
VAL A  63
ALA A  76
LEU A 108
ASN A 175
LEU A 177
 None
 0.71A 4o0sA-2hw6A:
25.8		 4o0sA-2hw6A:
31.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
GLY A 589
VAL A 596
ALA A 614
LYS A 616
ASN A 783
LEU A 785
 None
 0.54A 4o0sA-2ogvA:
23.3		 4o0sA-2ogvA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 LEU A 344
GLY A 345
VAL A 352
ALA A 367
LYS A 369
ASN A 466
LEU A 468
ASP A 479
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
ANP  A 615 ( 3.3A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
 0.95A 4o0sA-2ozoA:
22.7		 4o0sA-2ozoA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
VAL A 495
ALA A 515
LYS A 517
ASN A 631
LEU A 633
ASP A 644
 None
 0.52A 4o0sA-2psqA:
27.0		 4o0sA-2psqA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 204
ALA A 215
LYS A 217
LEU A 245
ASN A 326
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
None
ADE  A 488 (-4.4A)
None
 0.66A 4o0sA-2qluA:
24.5		 4o0sA-2qluA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 724
GLY A 725
VAL A 732
ALA A 749
LYS A 751
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.95A 4o0sA-2r4bA:
24.1		 4o0sA-2r4bA:
25.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
GLY A  69
VAL A  76
ALA A  92
LYS A  94
ASN A 192
ASP A 205
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.3A)
STU  A   1 ( 3.8A)
 0.88A 4o0sA-2z7rA:
29.0		 4o0sA-2z7rA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
GLY A  69
VAL A  76
ALA A  92
LYS A  94
ASN A 192
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
 0.66A 4o0sA-2z7rA:
29.0		 4o0sA-2z7rA:
30.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1002
GLY A1003
VAL A1010
ALA A1028
LYS A1030
ASN A1137
ASP A1150
 S91  A   1 ( 4.1A)
S91  A   1 ( 3.9A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
None
None
 0.81A 4o0sA-2z8cA:
28.2		 4o0sA-2z8cA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
GLY A 488
VAL A 495
ALA A 515
ASN A 631
LEU A 633
ASP A 644
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 (-4.5A)
M33  A1996 (-4.0A)
 0.67A 4o0sA-3b2tA:
27.5		 4o0sA-3b2tA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
GLY A 488
VAL A 495
ALA A 515
LYS A 517
ASN A 631
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 (-4.5A)
 0.81A 4o0sA-3b2tA:
27.5		 4o0sA-3b2tA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 202
VAL A 209
ALA A 220
LYS A 222
ASN A 319
LEU A 321
ASP A 332
 None
 0.94A 4o0sA-3d7uA:
27.4		 4o0sA-3d7uA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  24
VAL A  31
ALA A  44
LYS A  46
ASN A 151
LEU A 153
ASP A 164
 ANP  A   1 (-3.3A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
ANP  A   1 ( 3.4A)
None
ANP  A   1 (-3.8A)
 0.95A 4o0sA-3dakA:
25.7		 4o0sA-3dakA:
27.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		7 LEU A  29
GLY A  30
VAL A  37
ALA A  50
ASN A 151
LEU A 153
ASP A 167
 None
 0.66A 4o0sA-3dxnA:
29.5		 4o0sA-3dxnA:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  44
GLY A  45
VAL A  52
ALA A  65
LYS A  67
ASN A 172
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.6A)
985  A   1 ( 4.0A)
 0.90A 4o0sA-3f2aA:
23.1		 4o0sA-3f2aA:
30.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 431
GLY A 432
VAL A 439
ALA A 455
LYS A 457
ASN A 554
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 ( 4.2A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
None
AGS  A 999 (-4.5A)
 0.88A 4o0sA-3fzpA:
24.9		 4o0sA-3fzpA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 833
GLY A 834
VAL A 841
ALA A 859
LYS A 861
ASN A1027
LEU A1029
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
None
None
 0.70A 4o0sA-3hngA:
24.0		 4o0sA-3hngA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  82
GLY A  83
VAL A  90
ALA A 103
LYS A 105
ASN A 204
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 0.96A 4o0sA-3hztA:
23.7		 4o0sA-3hztA:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  82
GLY A  83
VAL A  90
ALA A 103
LYS A 105
ASN A 203
LEU A 205
 ANP  A 610 ( 4.5A)
ANP  A 610 (-3.5A)
ANP  A 610 (-3.9A)
ANP  A 610 ( 3.7A)
ANP  A 610 (-2.8A)
ANP  A 610 ( 4.9A)
None
 0.51A 4o0sA-3igoA:
24.9		 4o0sA-3igoA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  68
GLY A  69
VAL A  76
ALA A  89
LYS A  91
ASN A 189
ASP A 205
 ANP  A 522 (-4.6A)
ANP  A 522 (-3.5A)
ANP  A 522 (-4.1A)
ANP  A 522 (-3.6A)
ANP  A 522 (-3.5A)
MG  A 521 ( 2.9A)
MG  A 521 ( 3.6A)
 0.78A 4o0sA-3lijA:
31.2		 4o0sA-3lijA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  68
GLY A  69
VAL A  76
ALA A  89
LYS A  91
ASN A 189
LEU A 191
 ANP  A 522 (-4.6A)
ANP  A 522 (-3.5A)
ANP  A 522 (-4.1A)
ANP  A 522 (-3.6A)
ANP  A 522 (-3.5A)
MG  A 521 ( 2.9A)
ANP  A 522 (-4.7A)
 0.70A 4o0sA-3lijA:
31.2		 4o0sA-3lijA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 LEU A 680
GLY A 681
VAL A 689
ALA A 700
LYS A 702
ASN A 802
LEU A 804
 ADP  A2101 ( 4.1A)
ADP  A2101 (-3.6A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
MG  A2102 ( 2.9A)
ADP  A2101 (-4.4A)
 0.56A 4o0sA-3lj0A:
26.5		 4o0sA-3lj0A:
22.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  39
GLY A  40
VAL A  47
ALA A  60
ASN A 163
LEU A 165
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
None
None
QUE  A   1 (-2.9A)
 0.47A 4o0sA-3lm5A:
30.4		 4o0sA-3lm5A:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LYS A  62
ASN A 163
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
None
QUE  A   1 (-2.9A)
 0.88A 4o0sA-3lm5A:
30.4		 4o0sA-3lm5A:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		7 LEU A  40
GLY A  41
VAL A  48
ALA A  61
ASN A 162
LEU A 164
ASP A 178
 DXR  A 299 ( 4.3A)
DXR  A 299 ( 4.2A)
DXR  A 299 (-4.3A)
DXR  A 299 ( 3.9A)
None
None
None
 0.91A 4o0sA-3ma6A:
27.0		 4o0sA-3ma6A:
34.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 209
VAL A 216
ALA A 227
LYS A 229
LEU A 257
ASN A 335
LEU A 337
 None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.5A)
LDN  A 600 (-4.6A)
 0.85A 4o0sA-3my0A:
24.1		 4o0sA-3my0A:
28.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
GLY A  89
VAL A  96
ALA A 109
LYS A 111
ASN A 210
LEU A 212
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.3A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
None
None
 0.54A 4o0sA-3nuuA:
33.5		 4o0sA-3nuuA:
35.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 726
GLY A 727
VAL A 734
ALA A 751
ASN A 850
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.95A 4o0sA-3pp0A:
26.5		 4o0sA-3pp0A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 726
GLY A 727
VAL A 734
ALA A 751
LYS A 753
ASN A 850
LEU A 852
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
 0.94A 4o0sA-3pp0A:
26.5		 4o0sA-3pp0A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 GLY A 558
PHE A 562
VAL A 565
ALA A 576
ASN A 681
LEU A 683
ASP A 694
 STU  A   1 (-3.2A)
STU  A   1 ( 4.7A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.6A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.89A 4o0sA-3ppzA:
28.7		 4o0sA-3ppzA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  63
GLY A  64
VAL A  71
ALA A  84
LYS A  86
ASN A 195
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
CA  A 528 ( 3.0A)
MG  A 529 (-2.2A)
 0.84A 4o0sA-3q5iA:
27.3		 4o0sA-3q5iA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  63
GLY A  64
VAL A  71
ALA A  84
LYS A  86
ASN A 195
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
CA  A 528 ( 3.0A)
ANP  A1634 (-4.4A)
 0.62A 4o0sA-3q5iA:
27.3		 4o0sA-3q5iA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 345
GLY A 346
LYS A 368
LEU A 397
THR A 420
ASN A 465
LEU A 467
 STU  A   1 (-3.8A)
STU  A   1 (-3.4A)
STU  A   1 (-3.1A)
STU  A   1 (-4.6A)
STU  A   1 (-4.6A)
STU  A   1 (-4.5A)
STU  A   1 (-4.6A)
 0.85A 4o0sA-3s95A:
26.9		 4o0sA-3s95A:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  57
GLY A  58
VAL A  65
ALA A  78
LYS A  80
ASN A 179
LEU A 181
ASP A 195
 BK5  A 701 ( 4.2A)
BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
None
None
BK5  A 701 (-4.0A)
 0.93A 4o0sA-3sxfA:
26.7		 4o0sA-3sxfA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 423
GLY A 424
VAL A 431
ALA A 443
LYS A 445
ASN A 541
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-4.6A)
 0.79A 4o0sA-3sxsA:
27.1		 4o0sA-3sxsA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
VAL A 492
ALA A 512
ASN A 628
LEU A 630
ASP A 641
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
None
07J  A   1 ( 4.4A)
07J  A   1 (-4.7A)
 0.55A 4o0sA-3tt0A:
23.9		 4o0sA-3tt0A:
27.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 139
GLY A 140
VAL A 147
ALA A 160
LEU A 194
THR A 217
ASN A 261
LEU A 263
 N13  A 501 (-3.7A)
None
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-4.9A)
None
None
N13  A 501 (-4.5A)
 0.56A 4o0sA-3w18A:
33.5		 4o0sA-3w18A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 139
GLY A 140
VAL A 147
ALA A 160
LYS A 162
THR A 217
ASN A 261
LEU A 263
 N13  A 501 (-3.7A)
None
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-2.9A)
None
None
N13  A 501 (-4.5A)
 0.85A 4o0sA-3w18A:
33.5		 4o0sA-3w18A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  75
GLY A  76
VAL A  83
ALA A  96
LYS A  98
ASN A 196
LEU A 198
ASP A 209
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
MG  A 402 ( 2.9A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.87A 4o0sA-3wigA:
20.5		 4o0sA-3wigA:
28.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  83
GLY A  84
VAL A  91
ALA A 104
LEU A 138
ASN A 205
LEU A 207
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
None
None
VX6  A 500 (-4.6A)
 0.70A 4o0sA-4af3A:
29.3		 4o0sA-4af3A:
66.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
GLY A 841
VAL A 848
ALA A 866
LYS A 868
ASN A1033
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
B49  A2000 (-4.5A)
 0.60A 4o0sA-4agdA:
17.4		 4o0sA-4agdA:
25.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  42
GLY A  43
VAL A  50
ALA A  63
ASN A 162
LEU A 164
ASP A 175
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.9A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
None
XZN  A1317 (-4.7A)
XZN  A1317 (-3.2A)
 0.81A 4o0sA-4bc6A:
25.3		 4o0sA-4bc6A:
32.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 263
ASN A 341
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.67A 4o0sA-4c02A:
24.9		 4o0sA-4c02A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
ASN A 499
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.6A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
0SB  A 701 (-3.8A)
0SB  A 701 (-4.4A)
 0.90A 4o0sA-4f4pA:
26.3		 4o0sA-4f4pA:
26.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LYS A  49
ASN A 146
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-3.0A)
ATP  A 401 (-3.4A)
ATP  A 401 (-4.6A)
 0.68A 4o0sA-4fg8A:
26.9		 4o0sA-4fg8A:
32.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
ASN A 499
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
MG  A 702 ( 3.0A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.95A 4o0sA-4fl3A:
23.6		 4o0sA-4fl3A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
GLY A 856
VAL A 863
LYS A 882
ASN A 981
LEU A 983
ASP A 994
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
None
IZA  A2001 ( 4.7A)
IZA  A2001 ( 4.7A)
IZA  A2001 ( 4.7A)
IZA  A2001 ( 4.5A)
 0.92A 4o0sA-4gl9A:
27.3		 4o0sA-4gl9A:
27.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 156
GLY A 157
VAL A 164
ALA A 177
LYS A 179
ASN A 279
ASP A 292
 0XZ  A 501 ( 4.1A)
GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 503 ( 2.8A)
0XZ  A 501 ( 4.5A)
0XZ  A 501 ( 3.4A)
 0.58A 4o0sA-4gv1A:
32.6		 4o0sA-4gv1A:
31.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		8 LEU A 132
GLY A 133
VAL A 140
ALA A 156
LYS A 158
ASN A 257
LEU A 259
ASP A 270
 None
 0.86A 4o0sA-4hzsA:
23.5		 4o0sA-4hzsA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 132
GLY A 133
VAL A 140
ALA A 156
LYS A 158
ASN A 257
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
None
1G0  A 401 (-4.6A)
 0.65A 4o0sA-4id7A:
27.8		 4o0sA-4id7A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
GLY A 274
VAL A 281
ALA A 293
ASN A 391
LEU A 393
ASP A 404
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
None
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
 0.80A 4o0sA-4k11A:
25.3		 4o0sA-4k11A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
GLY A 479
VAL A 486
ALA A 506
LYS A 508
ASN A 622
LEU A 624
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
MG  A 802 ( 2.4A)
ACP  A 801 (-4.4A)
 0.61A 4o0sA-4k33A:
21.4		 4o0sA-4k33A:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
ASN A 391
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.5A)
 0.81A 4o0sA-4lggA:
23.9		 4o0sA-4lggA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 273
VAL A 281
ALA A 293
LYS A 295
ASN A 391
LEU A 393
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.69A 4o0sA-4lggA:
23.9		 4o0sA-4lggA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		7 GLY A 198
VAL A 205
ALA A 218
LYS A 220
ASN A 322
LEU A 324
ASP A 335
 29X  A 702 ( 4.1A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
29X  A 702 (-4.4A)
 0.92A 4o0sA-4mk0A:
22.9		 4o0sA-4mk0A:
18.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 386
GLY A 387
VAL A 394
ALA A 407
LYS A 409
ASN A 509
LEU A 511
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.4A)
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.69A 4o0sA-4q9zA:
30.8		 4o0sA-4q9zA:
31.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  76
GLY A  77
VAL A  84
ALA A  97
LYS A  99
ASN A 198
ASP A 215
 None
 0.92A 4o0sA-4rgjA:
25.5		 4o0sA-4rgjA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
ASN A 816
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-4.6A)
 0.62A 4o0sA-4rt7A:
19.0		 4o0sA-4rt7A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 GLY A 193
VAL A 200
ALA A 213
LYS A 215
ASN A 316
LEU A 318
ASP A 329
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.77A 4o0sA-4tnbA:
23.2		 4o0sA-4tnbA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
GLY A 193
VAL A 200
ALA A 213
ASN A 316
LEU A 318
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.69A 4o0sA-4tnbA:
23.2		 4o0sA-4tnbA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 151
VAL A 158
ALA A 169
LYS A 171
ASN A 273
LEU A 275
ASP A 294
 None
 0.85A 4o0sA-4uy9A:
23.3		 4o0sA-4uy9A:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
ASN A 319
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 (-4.9A)
 0.78A 4o0sA-4wboA:
31.0		 4o0sA-4wboA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 473
GLY A 474
VAL A 481
ALA A 501
LYS A 503
ASN A 617
LEU A 619
ASP A 630
 40M  A1002 ( 4.6A)
None
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
None
40M  A1002 (-4.5A)
40M  A1002 (-4.5A)
 0.92A 4o0sA-4xcuA:
24.4		 4o0sA-4xcuA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
ASN A 317
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
 0.80A 4o0sA-4yhjA:
28.5		 4o0sA-4yhjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		PF00069
(Pkinase) 		8 GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  80
ASN A 147
LEU A 149
ASP A 160
 None
 0.87A 4o0sA-4ynzA:
27.7		 4o0sA-4ynzA:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		PF00069
(Pkinase) 		8 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  80
ASN A 147
ASP A 160
 None
 0.85A 4o0sA-4ynzA:
27.7		 4o0sA-4ynzA:
28.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  34
GLY A  35
VAL A  42
ALA A  55
LYS A  57
ASN A 156
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
MG  A 505 ( 2.7A)
ADP  A 506 (-4.7A)
 0.64A 4o0sA-4ysjA:
32.6		 4o0sA-4ysjA:
31.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		9 LEU A 577
GLY A 578
VAL A 586
ALA A 597
LYS A 599
THR A 648
ASN A 693
LEU A 695
ASP A 711
 None
 0.68A 4o0sA-4z7gA:
21.7		 4o0sA-4z7gA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
GLY A 485
VAL A 492
ALA A 512
LYS A 514
ASN A 628
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
None
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.55A 4o0sA-5a46A:
24.1		 4o0sA-5a46A:
25.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  23
VAL A  30
ALA A  44
LYS A  46
ASN A 143
LEU A 145
ASP A 165
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
GOL  A 404 ( 4.6A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 0.56A 4o0sA-5ci7A:
24.6		 4o0sA-5ci7A:
32.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 251
VAL A 258
ALA A 275
LYS A 277
LEU A 305
ASN A 384
LEU A 386
 STU  A 601 (-2.9A)
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 4.9A)
STU  A 601 (-3.9A)
 0.75A 4o0sA-5e8yA:
18.8		 4o0sA-5e8yA:
26.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 LEU A  99
GLY A 100
VAL A 107
ALA A 120
LYS A 122
LEU A 154
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.8A)
5U5  A 401 (-4.7A)
 0.51A 4o0sA-5eykA:
31.4		 4o0sA-5eykA:
68.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LYS A 930
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.92A 4o0sA-5f1zA:
21.4		 4o0sA-5f1zA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 730
GLY A 731
VAL A 738
ALA A 756
LYS A 758
ASN A 879
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.6A)
 0.84A 4o0sA-5fm2A:
27.5		 4o0sA-5fm2A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
GLY A 600
VAL A 607
ALA A 625
LYS A 627
ASN A 823
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
None
748  A1001 (-4.3A)
 0.68A 4o0sA-5grnA:
18.0		 4o0sA-5grnA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 718
VAL A 726
ALA A 743
LYS A 745
ASN A 842
LEU A 844
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-4.3A)
 0.86A 4o0sA-5j9zA:
25.4		 4o0sA-5j9zA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 8 LEU A  17
GLY A  18
VAL A  25
ALA A  38
LYS A  40
THR A  99
ASN A 143
ASP A 156
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
None
MG  A 310 (-3.2A)
G93  A 301 ( 3.2A)
 0.95A 4o0sA-5u94A:
30.1		 4o0sA-5u94A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 GLY A 198
VAL A 205
ALA A 218
LYS A 220
ASN A 322
LEU A 324
ASP A 335
 QRW  A 601 ( 4.5A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
None
None
QRW  A 601 (-3.7A)
 0.89A 4o0sA-5uuuA:
30.6		 4o0sA-5uuuA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 LEU A  24
VAL A  32
ALA A  45
LYS A  47
LEU A  79
ASN A 151
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
None
9WS  A 401 (-4.6A)
 0.57A 4o0sA-5w5jA:
22.4		 4o0sA-5w5jA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 8 LEU A 891
GLY A 892
VAL A 899
ALA A 917
LEU A 947
ASN A1015
LEU A1017
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
MG  A1202 ( 2.9A)
ANP  A1201 (-4.7A)
MG  A1202 ( 3.0A)
 0.95A 4o0sA-5wnoA:
22.7		 4o0sA-5wnoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 8 LEU A  33
GLY A  34
VAL A  41
ALA A  54
LYS A  56
ASN A 151
LEU A 153
ASP A 164
 ANP  A 501 ( 3.8A)
ANP  A 501 ( 3.9A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
ANP  A 501 ( 2.6A)
ANP  A 501 (-4.6A)
MG  A 502 ( 3.1A)
 1.18A 4o0sA-6ao5A:
14.4		 4o0sA-6ao5A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 7 LEU A 366
GLY A 367
VAL A 374
ALA A 388
LYS A 390
ASN A 489
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
EE4  A 701 ( 4.9A)
DMS  A 702 ( 3.1A)
 0.73A 4o0sA-6c0tA:
32.9		 4o0sA-6c0tA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
GLY A 882
VAL A 889
ALA A 906
LYS A 908
ASN A1008
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
MG  A1202 ( 2.5A)
ADP  A1201 (-4.5A)
 0.75A 4o0sA-6c7yA:
26.6		 4o0sA-6c7yA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 7 LEU A 167
GLY A 168
VAL A 175
ALA A 189
LYS A 191
ASN A 293
LEU A 295
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
None
EAQ  A 501 (-4.9A)
 0.68A 4o0sA-6fyoA:
26.7		 4o0sA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 7 LEU A 167
GLY A 168
VAL A 175
ALA A 189
LYS A 191
ASN A 293
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
None
None
 0.72A 4o0sA-6fyvA:
26.5		 4o0sA-6fyvA:
undetectable