SIMILAR PATTERNS OF AMINO ACIDS FOR 4O0O_A_URFA303_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1abr ABRIN-A

(Abrus
precatorius) 		PF00161
(RIP) 		4 TYR A  74
TYR A 113
ILE A 159
ARG A 167
 None
 0.34A 4o0oA-1abrA:
33.7		 4o0oA-1abrA:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aha ALPHA-MOMORCHARIN

(Momordica
charantia) 		PF00161
(RIP) 		5 TYR A  70
ASN A 110
TYR A 111
ILE A 155
ARG A 163
 ADE  A 339 ( 3.8A)
None
ADE  A 339 ( 3.6A)
ADE  A 339 (-4.1A)
ADE  A 339 ( 2.9A)
 0.52A 4o0oA-1ahaA:
43.7		 4o0oA-1ahaA:
94.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1apa POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
americana) 		PF00161
(RIP) 		4 TYR A  77
TYR A 128
ILE A 175
ARG A 183
 None
 0.50A 4o0oA-1apaA:
30.8		 4o0oA-1apaA:
29.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bry BRYODIN I

(Bryonia dioica) 		PF00161
(RIP) 		5 TYR Y  70
ASN Y 110
TYR Y 111
ILE Y 155
ARG Y 163
 None
 0.68A 4o0oA-1bryY:
41.6		 4o0oA-1bryY:
66.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ce7 PROTEIN
(RIBOSOME-INACTIVATI
NG PROTEIN TYPE II)

(Viscum album) 		PF00161
(RIP) 		4 TYR A  75
ASN A 108
ILE A 155
ARG A 163
 None
NAG  A 303 (-2.7A)
None
None
 0.99A 4o0oA-1ce7A:
32.0		 4o0oA-1ce7A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ce7 PROTEIN
(RIBOSOME-INACTIVATI
NG PROTEIN TYPE II)

(Viscum album) 		PF00161
(RIP) 		4 TYR A  75
TYR A 111
ILE A 155
ARG A 163
 None
 0.47A 4o0oA-1ce7A:
32.0		 4o0oA-1ce7A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cf5 PROTEIN
(BETA-MOMORCHARIN)

(Momordica
charantia) 		PF00161
(RIP) 		5 TYR A  70
ASN A 108
TYR A 109
ILE A 153
ARG A 161
 None
 0.68A 4o0oA-1cf5A:
38.3		 4o0oA-1cf5A:
52.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		4 TYR A 167
ASN A 103
TYR A 405
ILE A 187
 None
ONL  A 505 (-4.4A)
None
None
 1.37A 4o0oA-1ecgA:
undetectable		 4o0oA-1ecgA:
19.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hwn EBULIN

(Sambucus ebulus) 		PF00161
(RIP) 		5 TYR A  77
ASN A 115
TYR A 116
ILE A 158
ARG A 166
 None
 0.57A 4o0oA-1hwnA:
32.7		 4o0oA-1hwnA:
38.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 TYR A 415
ASN A 278
TYR A 279
ILE A 418
 None
 1.28A 4o0oA-1iv8A:
undetectable		 4o0oA-1iv8A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		4 TYR A 125
ASN A 142
TYR A 143
ILE A 104
 None
 1.41A 4o0oA-1jmyA:
undetectable		 4o0oA-1jmyA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpc DIANTHIN 30

(Dianthus
caryophyllus) 		PF00161
(RIP) 		4 TYR A  73
TYR A 121
ILE A 172
ARG A 180
 CMP  A 901 (-4.1A)
CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 (-3.0A)
 0.20A 4o0oA-1lpcA:
27.7		 4o0oA-1lpcA:
26.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nio B-LUFFIN

(Luffa
aegyptiaca) 		PF00161
(RIP) 		5 TYR A  71
ASN A 110
TYR A 111
ILE A 155
ARG A 163
 None
 0.28A 4o0oA-1nioA:
41.0		 4o0oA-1nioA:
68.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qcj POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
americana) 		PF00161
(RIP) 		4 TYR A  72
TYR A 123
ILE A 171
ARG A 179
 APT  A 901 (-3.9A)
APT  A 901 (-4.7A)
APT  A 901 (-3.7A)
APT  A 901 (-3.0A)
 0.37A 4o0oA-1qcjA:
31.0		 4o0oA-1qcjA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi7 PROTEIN
(N-GLYCOSIDASE)

(Saponaria
officinalis) 		PF00161
(RIP) 		4 TYR A  72
TYR A 120
ILE A 171
ARG A 179
 None
 0.51A 4o0oA-1qi7A:
27.7		 4o0oA-1qi7A:
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tcs TRICHOSANTHIN

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		5 TYR A  70
ASN A 110
TYR A 111
ILE A 155
ARG A 163
 NDP  A 280 ( 4.7A)
None
NDP  A 280 ( 3.7A)
NDP  A 280 (-3.9A)
NDP  A 280 ( 2.6A)
 0.35A 4o0oA-1tcsA:
40.4		 4o0oA-1tcsA:
64.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE

(Clostridium
perfringens) 		PF00722
(Glyco_hydro_16) 		4 ASN A  66
TYR A  67
ILE A  98
ARG A  45
 None
 1.49A 4o0oA-1upsA:
undetectable		 4o0oA-1upsA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1url SIALOADHESIN

(Mus musculus) 		PF07686
(V-set) 		4 ASN A  95
TYR A  41
ILE A  39
ARG A 105
 None
 1.34A 4o0oA-1urlA:
undetectable		 4o0oA-1urlA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybi NON-TOXIN
HAEMAGGLUTININ HA34

(Clostridium
botulinum) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		4 TYR A 201
ASN A 241
TYR A 250
ILE A 290
 None
 1.16A 4o0oA-1ybiA:
undetectable		 4o0oA-1ybiA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csk SORTING NEXIN 12

(Homo sapiens) 		PF00787
(PX) 		4 ASN A  17
TYR A  31
ILE A  97
ARG A  27
 None
 1.36A 4o0oA-2cskA:
undetectable		 4o0oA-2cskA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2md5 TRANSCRIPTION FACTOR
ETV6

(Mus musculus) 		PF00178
(Ets) 		4 ASN A 370
TYR A 387
ILE A 366
ARG A 410
 None
 1.41A 4o0oA-2md5A:
undetectable		 4o0oA-2md5A:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oqa LUFFACULIN 1

(Luffa
acutangula) 		PF00161
(RIP) 		5 TYR A  70
ASN A 109
TYR A 110
ILE A 154
ARG A 162
 None
 0.73A 4o0oA-2oqaA:
40.5		 4o0oA-2oqaA:
69.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8w POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
acinosa) 		PF00161
(RIP) 		4 TYR A  72
TYR A 122
ILE A 170
ARG A 178
 None
 0.34A 4o0oA-2q8wA:
31.0		 4o0oA-2q8wA:
29.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4

(Phytolacca
dioica) 		PF00161
(RIP) 		4 TYR A  72
TYR A 122
ILE A 170
ARG A 178
 ADE  A 501 (-3.8A)
ADE  A 501 (-3.7A)
ADE  A 501 (-4.0A)
ADE  A 501 (-2.9A)
 0.55A 4o0oA-2qesA:
31.2		 4o0oA-2qesA:
30.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		4 TYR A  75
TYR A 115
ILE A 162
ARG A 170
 None
 0.61A 4o0oA-2vlcA:
30.8		 4o0oA-2vlcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		4 TYR A 396
ASN A 394
TYR A 393
ILE A 407
 XYP  A1001 ( 4.8A)
None
None
None
 1.30A 4o0oA-2w5fA:
undetectable		 4o0oA-2w5fA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygk NURA

(Sulfolobus
solfataricus) 		PF09376
(NurA) 		4 TYR A 256
ASN A 236
ILE A 233
ARG A 271
 None
 1.40A 4o0oA-2ygkA:
undetectable		 4o0oA-2ygkA:
18.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zr1 AGGLUTININ-1 CHAIN A

(Abrus
precatorius) 		PF00161
(RIP) 		4 TYR A  73
TYR A 112
ILE A 158
ARG A 166
 None
 0.57A 4o0oA-2zr1A:
33.6		 4o0oA-2zr1A:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bwh CUCURMOSIN

(Cucurbita
moschata) 		PF00161
(RIP) 		5 TYR A  70
ASN A 108
TYR A 109
ILE A 153
ARG A 161
 EDO  A 253 ( 4.5A)
None
EDO  A 253 ( 4.1A)
EDO  A 253 ( 4.1A)
EDO  A 253 (-2.9A)
 0.43A 4o0oA-3bwhA:
39.3		 4o0oA-3bwhA:
58.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctk RRNA N-GLYCOSIDASE

(Bougainvillea
spectabilis) 		PF00161
(RIP) 		4 TYR A  70
TYR A 114
ILE A 160
ARG A 168
 None
 0.35A 4o0oA-3ctkA:
33.2		 4o0oA-3ctkA:
29.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emq ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		4 TYR A 179
ASN A 177
TYR A 176
ILE A 190
 HAH  A1000 (-3.9A)
None
None
None
 1.31A 4o0oA-3emqA:
undetectable		 4o0oA-3emqA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5k RIBOSOME-INACTIVATIN
G PROTEIN
PD-L1/PD-L2

(Phytolacca
dioica) 		PF00161
(RIP) 		4 TYR A  72
TYR A 122
ILE A 170
ARG A 178
 EDO  A 264 ( 4.9A)
EDO  A 264 (-3.5A)
EDO  A 264 (-4.0A)
None
 0.34A 4o0oA-3h5kA:
31.2		 4o0oA-3h5kA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1u CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1, SERYL
T-RNA SYNTHETASE
CHIMERA

(Mus musculus) 		PF12777
(MT) 		4 TYR A3377
ASN A3376
TYR A3375
ILE A3395
 None
 1.48A 4o0oA-3j1uA:
undetectable		 4o0oA-3j1uA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		4 TYR A 478
ASN A 415
TYR A 416
ARG A 348
 None
 1.15A 4o0oA-3jclA:
undetectable		 4o0oA-3jclA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq0 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ASN A 343
TYR A 425
ILE A 437
ARG A 471
 None
 1.33A 4o0oA-3jq0A:
undetectable		 4o0oA-3jq0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msg INTRA-CELLULAR
XYLANASE IXT6

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		4 TYR A 179
ASN A 177
TYR A 176
ILE A 190
 XYP  A 449 (-3.4A)
None
None
None
 1.32A 4o0oA-3msgA:
undetectable		 4o0oA-3msgA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF00385
(Chromo) 		4 TYR W 245
ASN W 244
ILE W 181
ARG W 277
 None
 1.37A 4o0oA-3mwyW:
undetectable		 4o0oA-3mwyW:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n8u IMELYSIN PEPTIDASE

(Bacteroides
ovatus) 		PF09375
(Peptidase_M75) 		4 TYR A 153
ASN A 157
TYR A 160
ILE A 191
 None
 1.47A 4o0oA-3n8uA:
undetectable		 4o0oA-3n8uA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7z BETA-LACTAMASE
REGULATORY PROTEIN
BLAR1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		4 ASN A 345
TYR A 347
ILE A 375
ARG A 382
 None
 1.42A 4o0oA-3q7zA:
undetectable		 4o0oA-3q7zA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 TYR A 356
ASN A 424
TYR A 423
ILE A 353
 None
 1.21A 4o0oA-4c2xA:
undetectable		 4o0oA-4c2xA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF02128
(Peptidase_M36) 		4 TYR A 287
ASN A 293
TYR A 379
ILE A 296
 None
 1.25A 4o0oA-4k90A:
undetectable		 4o0oA-4k90A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 TYR A  98
ASN A 407
TYR A 405
ILE A 415
 None
 1.16A 4o0oA-4mmoA:
undetectable		 4o0oA-4mmoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ouj HEMAGGLUTININ
COMPONENT HA33

(Clostridium
botulinum) 		PF14200
(RicinB_lectin_2) 		4 TYR A 203
ASN A 242
TYR A 251
ILE A 291
 None
 1.37A 4o0oA-4oujA:
undetectable		 4o0oA-4oujA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ay7 XYLANASE

(Aegilops
speltoides) 		PF00331
(Glyco_hydro_10) 		4 TYR A 181
ASN A 179
TYR A 178
ILE A 192
 None
 1.33A 4o0oA-5ay7A:
undetectable		 4o0oA-5ay7A:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ddz RICIN

(Ricinus
communis) 		PF00161
(RIP) 		4 ASN A 122
TYR A 123
ILE A 172
ARG A 180
 None
 0.53A 4o0oA-5ddzA:
34.3		 4o0oA-5ddzA:
32.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofk GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF00331
(Glyco_hydro_10) 		4 TYR A 185
ASN A 183
TYR A 182
ILE A 196
 XYP  A 412 (-3.6A)
None
None
None
 1.33A 4o0oA-5ofkA:
undetectable		 4o0oA-5ofkA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1

(Saccharomyces
cerevisiae) 		no annotation 4 TYR A 377
ASN A 380
TYR A 447
ILE A 375
 None
 1.45A 4o0oA-5y58A:
undetectable		 4o0oA-5y58A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF

(Caldanaerobacter
subterraneus) 		no annotation 4 TYR A 148
ASN A 199
TYR A 200
ILE A 144
 None
 1.35A 4o0oA-5z67A:
undetectable		 4o0oA-5z67A:
15.28