SIMILAR PATTERNS OF AMINO ACIDS FOR 4NX6_A_FOLA201_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1foh | PHENOL HYDROXYLASE (Cutaneotrichosporoncutaneum) |
PF01494(FAD_binding_3)PF07976(Phe_hydrox_dim) | 4 | ILE A 457ASP A 376ARG A 619THR A 372 | None | 1.50A | 4nx6A-1fohA:undetectable | 4nx6A-1fohA:13.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ile | ISOLEUCYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1) | 4 | ILE A 155ASP A 520ARG A 510THR A 149 | None | 1.19A | 4nx6A-1ileA:undetectable | 4nx6A-1ileA:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kte | THIOLTRANSFERASE (Sus scrofa) |
PF00462(Glutaredoxin) | 4 | ILE A 47ASP A 52ARG A 67THR A 50 | None | 1.50A | 4nx6A-1kteA:undetectable | 4nx6A-1kteA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p5v | F1 CAPSULE ANTIGEN (Yersinia pestis) |
PF09255(Antig_Caf1) | 4 | ILE B 98ASP B 111ARG B 94THR B 58 | None | 1.47A | 4nx6A-1p5vB:undetectable | 4nx6A-1p5vB:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ydo | HMG-COA LYASE (Bacillussubtilis) |
PF00682(HMGL-like) | 4 | ILE A 31ASP A 61ARG A 71THR A 27 | None | 1.24A | 4nx6A-1ydoA:undetectable | 4nx6A-1ydoA:16.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zdr | DIHYDROFOLATEREDUCTASE (Geobacillusstearothermophilus) |
PF00186(DHFR_1) | 4 | ILE A 5ASP A 27ARG A 57THR A 115 | NoneNoneSO4 A3484 (-3.3A)None | 0.37A | 4nx6A-1zdrA:25.4 | 4nx6A-1zdrA:40.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2blb | DIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumvivax) |
PF00186(DHFR_1) | 4 | ILE A 13ASP A 53ARG A 131THR A 194 | CP7 A1240 (-4.1A)CP7 A1240 (-3.1A)MES A1241 (-2.7A)CP7 A1240 (-4.1A) | 0.35A | 4nx6A-2blbA:20.6 | 4nx6A-2blbA:24.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hi0 | PUTATIVEPHOSPHOGLYCOLATEPHOSPHATASE (Lactobacillusdelbrueckii) |
PF13419(HAD_2) | 4 | ILE A 43ASP A 11ARG A 57THR A 17 | None | 1.10A | 4nx6A-2hi0A:3.0 | 4nx6A-2hi0A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2is8 | MOLYBDOPTERINBIOSYNTHESIS ENZYME,MOAB (Thermusthermophilus) |
PF00994(MoCF_biosynth) | 4 | ILE A 26ASP A 20ARG A 136THR A 8 | NoneFMT A1003 (-3.7A)NoneFMT A1003 (-4.1A) | 1.20A | 4nx6A-2is8A:undetectable | 4nx6A-2is8A:21.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2w9s | DIHYDROFOLATEREDUCTASE TYPE 1FROM TN4003 (Staphylococcusaureus) |
PF00186(DHFR_1) | 4 | ILE A 5ASP A 27ARG A 57THR A 111 | TOP A1160 (-4.2A)TOP A1160 (-2.8A)NoneTOP A1160 ( 4.5A) | 0.46A | 4nx6A-2w9sA:26.0 | 4nx6A-2w9sA:38.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zki | 199AA LONGHYPOTHETICAL TRPREPRESSOR BINDINGPROTEIN (Sulfurisphaeratokodaii) |
PF03358(FMN_red) | 4 | ILE A 179ASP A 173ARG A 181THR A 156 | NoneNoneSO4 A 505 ( 2.9A)None | 1.24A | 4nx6A-2zkiA:undetectable | 4nx6A-2zkiA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dg8 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1) | 4 | ILE A 14ASP A 54ARG A 122THR A 185 | RJ6 A 609 (-4.5A)RJ6 A 609 (-3.0A)NoneRJ6 A 609 ( 4.5A) | 0.27A | 4nx6A-3dg8A:20.9 | 4nx6A-3dg8A:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lqk | DIPICOLINATESYNTHASE SUBUNIT B (Bacillushalodurans) |
PF02441(Flavoprotein) | 4 | ILE A 141ASP A 132ARG A 143THR A 130 | None | 1.46A | 4nx6A-3lqkA:undetectable | 4nx6A-3lqkA:18.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tq9 | DIHYDROFOLATEREDUCTASE (Coxiellaburnetii) |
PF00186(DHFR_1) | 4 | ILE A 6ASP A 28ARG A 58THR A 115 | MTX A2001 (-4.0A)MTX A2001 (-2.7A)MTX A2001 (-2.8A)MTX A2001 (-4.3A) | 0.24A | 4nx6A-3tq9A:26.1 | 4nx6A-3tq9A:43.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3um6 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 4 | ILE A 14ASP A 54ARG A 122THR A 185 | 1CY A 609 (-4.3A)1CY A 609 (-2.9A)None1CY A 609 (-4.3A) | 0.29A | 4nx6A-3um6A:20.8 | 4nx6A-3um6A:13.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zbi | TRAF PROTEIN (Escherichiacoli) |
PF03743(TrbI) | 4 | ILE A 873ASP A 838ARG A 846THR A 876 | None | 1.38A | 4nx6A-3zbiA:undetectable | 4nx6A-3zbiA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kp2 | HOMOACONITASE LARGESUBUNIT (Methanocaldococcusjannaschii) |
PF00330(Aconitase) | 4 | ILE A 221ASP A 224ARG A 156THR A 227 | None | 1.17A | 4nx6A-4kp2A:undetectable | 4nx6A-4kp2A:18.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m2x | DIHYDROFOLATEREDUCTASE (Mycobacteriumtuberculosis) |
PF00186(DHFR_1) | 4 | ILE A 5ASP A 27ARG A 60THR A 113 | TMQ A 202 (-4.0A)TMQ A 202 ( 2.7A)NoneTMQ A 202 (-4.2A) | 0.37A | 4nx6A-4m2xA:23.2 | 4nx6A-4m2xA:35.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m7v | DIHYDROFOLATEREDUCTASE (Enterococcusfaecalis) |
PF00186(DHFR_1) | 4 | ILE A 5ASP A 27ARG A 58THR A 116 | RAR A 200 (-4.0A)RAR A 200 (-2.6A)RAR A 200 ( 3.2A)RAR A 200 (-4.4A) | 0.51A | 4nx6A-4m7vA:25.1 | 4nx6A-4m7vA:37.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p68 | DIHYDROFOLATEREDUCTASE (Escherichiacoli) |
PF00186(DHFR_1) | 4 | ILE A 5ASP A 27ARG A 57THR A 113 | MTX A 201 (-4.1A)MTX A 201 (-3.0A)MTX A 201 (-3.0A)MTX A 201 ( 4.5A) | 0.22A | 4nx6A-4p68A:30.7 | 4nx6A-4p68A:98.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgc | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 4ORIGIN RECOGNITIONCOMPLEX SUBUNIT 5 (Drosophilamelanogaster;Drosophilamelanogaster) |
PF13191(AAA_16)PF14629(ORC4_C)PF13191(AAA_16)PF14630(ORC5_C) | 4 | ILE D 238ASP D 22ARG E 115THR D 25 | None | 1.09A | 4nx6A-4xgcD:undetectable | 4nx6A-4xgcD:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zv3 | CYTOSOLIC ACYLCOENZYME A THIOESTERHYDROLASE (Mus musculus) |
PF03061(4HBT) | 4 | ILE A 80ASP A 259ARG A 62THR A 276 | None | 1.47A | 4nx6A-4zv3A:undetectable | 4nx6A-4zv3A:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i2h | O-METHYLTRANSFERASEFAMILY 2 (Planctopiruslimnophila) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 4 | ILE A 206ASP A 199ARG A 165THR A 208 | NoneNoneAGI A 501 (-2.8A)None | 1.44A | 4nx6A-5i2hA:undetectable | 4nx6A-5i2hA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ldn | HEXON PROTEIN,HEXONCAPSID (HumanmastadenovirusC) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 4 | ILE A 858ASP A 807ARG A 802THR A 808 | None | 1.27A | 4nx6A-5ldnA:undetectable | 4nx6A-5ldnA:9.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cxm | DIHYDROFOLATEREDUCTASE (Mycolicibacteriumsmegmatis) |
no annotation | 4 | ILE A 6ASP A 28ARG A 61THR A 111 | MMV A 202 (-4.0A)MMV A 202 (-2.9A)MMV A 202 (-2.8A)MMV A 202 (-4.4A) | 0.32A | 4nx6A-6cxmA:21.9 | 4nx6A-6cxmA:undetectable |