SIMILAR PATTERNS OF AMINO ACIDS FOR 4NPT_A_017A401_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aec | ACTINIDIN (Actinidiachinensis) |
PF00112(Peptidase_C1) | 5 | ALA A 127ILE A 166GLY A 168THR A 33ILE A 37 | None | 1.09A | 4nptA-1aecA:0.7 | 4nptA-1aecA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ao0 | GLUTAMINEPHOSPHORIBOSYLPYROPHOSPHATEAMIDOTRANSFERASE (Bacillussubtilis) |
PF00156(Pribosyltran)PF13522(GATase_6) | 5 | ALA A 287GLY A 424ILE A 425ILE A 373VAL A 344 | None | 1.15A | 4nptA-1ao0A:0.0 | 4nptA-1ao0A:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bkh | MUCONATE LACTONIZINGENZYME (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 111ILE A 307GLY A 308ILE A 274ILE A 71 | None | 1.11A | 4nptA-1bkhA:0.0 | 4nptA-1bkhA:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fcd | FLAVOCYTOCHROME CSULFIDEDEHYDROGENASE(FLAVIN-BINDINGSUBUNIT) (Allochromatiumvinosum) |
PF07992(Pyr_redox_2)PF09242(FCSD-flav_bind) | 5 | ALA A 173ILE A 49ILE A 340ILE A 187VAL A 185 | None | 1.04A | 4nptA-1fcdA:0.0 | 4nptA-1fcdA:15.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gom | ENDO-1,4-BETA-XYLANASE (Thermoascusaurantiacus) |
PF00331(Glyco_hydro_10) | 5 | ALA A 254ILE A 264GLY A 263THR A 208VAL A 218 | None | 1.09A | 4nptA-1gomA:undetectable | 4nptA-1gomA:15.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hyg | L-LACTATE/MALATEDEHYDROGENASE (Methanocaldococcusjannaschii) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ALA A 255ILE A 175GLY A 176ILE A 303VAL A 283 | None | 1.05A | 4nptA-1hygA:0.0 | 4nptA-1hygA:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k0r | NUSA (Mycobacteriumtuberculosis) |
PF08529(NusA_N)PF13184(KH_5) | 5 | ALA A 231ILE A 236GLY A 237ILE A 207VAL A 222 | None | 0.99A | 4nptA-1k0rA:undetectable | 4nptA-1k0rA:15.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o4v | PHOSPHORIBOSYLAMINOIMIDAZOLE MUTASE PURE (Thermotogamaritima) |
PF00731(AIRC) | 5 | ALA A 125ILE A 136GLY A 130ILE A 131ILE A 57 | None | 1.17A | 4nptA-1o4vA:0.0 | 4nptA-1o4vA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ps9 | 2,4-DIENOYL-COAREDUCTASE (Escherichiacoli) |
PF00724(Oxidored_FMN)PF07992(Pyr_redox_2) | 5 | ALA A 657GLY A 410ILE A 414THR A 427ILE A 335 | FAD A 701 (-3.1A)FAD A 701 (-2.9A)FAD A 701 (-3.9A)NoneSF4 A 700 (-4.8A) | 1.14A | 4nptA-1ps9A:0.0 | 4nptA-1ps9A:10.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ptj | NAD(P)TRANSHYDROGENASESUBUNIT ALPHA PART 1 (Rhodospirillumrubrum) |
PF01262(AlaDh_PNT_C)PF05222(AlaDh_PNT_N) | 5 | ALA A 196GLY A 152ILE A 150ILE A 188VAL A 198 | None | 1.05A | 4nptA-1ptjA:undetectable | 4nptA-1ptjA:13.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rbl | RIBULOSE 1,5BISPHOSPHATECARBOXYLASE/OXYGENASE (LARGE CHAIN) (Synechococcuselongatus) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | ALA A 389GLY A 442ILE A 444ILE A 382VAL A 332 | None | 1.16A | 4nptA-1rblA:undetectable | 4nptA-1rblA:12.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3q | QUINOLINE2-OXIDOREDUCTASELARGE SUBUNIT (Pseudomonasputida) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | GLY B 378ILE B 380THR B 321ILE B 367VAL B 335 | None | 1.15A | 4nptA-1t3qB:undetectable | 4nptA-1t3qB:8.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tkk | SIMILAR TOCHLOROMUCONATECYCLOISOMERASE (Bacillussubtilis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 106GLY A 274MET A 270ILE A 66VAL A 34 | None | 1.10A | 4nptA-1tkkA:undetectable | 4nptA-1tkkA:14.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v6c | ALKALINE SERINEPROTEASE (Pseudoalteromonassp. AS-11) |
PF00082(Peptidase_S8)PF02225(PA) | 5 | ALA A 123ILE A 95GLY A 47ILE A 114VAL A 126 | None | 1.03A | 4nptA-1v6cA:undetectable | 4nptA-1v6cA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vdw | HYPOTHETICAL PROTEINPH1897 (Pyrococcushorikoshii) |
PF00459(Inositol_P) | 5 | ALA A 214ILE A 208GLY A 205ILE A 202VAL A 142 | None | 1.15A | 4nptA-1vdwA:undetectable | 4nptA-1vdwA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wpq | GLYCEROL-3-PHOSPHATEDEHYDROGENASE[NAD+], CYTOPLASMIC (Homo sapiens) |
PF01210(NAD_Gly3P_dh_N)PF07479(NAD_Gly3P_dh_C) | 5 | ALA A 83ILE A 142GLY A 115ILE A 116ILE A 101 | None | 1.12A | 4nptA-1wpqA:undetectable | 4nptA-1wpqA:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2asb | TRANSCRIPTIONELONGATION PROTEINNUSA (Mycobacteriumtuberculosis) |
PF13184(KH_5) | 5 | ALA A 231ILE A 236GLY A 237ILE A 207VAL A 222 | None G B 1 ( 4.0A)NoneNoneNone | 0.97A | 4nptA-2asbA:undetectable | 4nptA-2asbA:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c4m | GLYCOGENPHOSPHORYLASE (Corynebacteriumcallunae) |
PF00343(Phosphorylase) | 5 | ASN A 764ILE A 664GLY A 644MET A 646VAL A 657 | None | 1.09A | 4nptA-2c4mA:undetectable | 4nptA-2c4mA:8.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cf5 | CINNAMYL ALCOHOLDEHYDROGENASE (Arabidopsisthaliana) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 159ILE A 41GLY A 73ILE A 90VAL A 347 | None | 0.94A | 4nptA-2cf5A:undetectable | 4nptA-2cf5A:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ch1 | 3-HYDROXYKYNURENINETRANSAMINASE (Anophelesgambiae) |
PF00266(Aminotran_5) | 5 | ALA A 180ILE A 63ILE A 284THR A 66VAL A 199 | None | 1.16A | 4nptA-2ch1A:undetectable | 4nptA-2ch1A:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cwl | MANGANESE-FREEPSEUDOCATALASE (Thermusthermophilus) |
PF05067(Mn_catalase) | 5 | ALA A 28ILE A 81ILE A 74ILE A 178VAL A 165 | None | 1.15A | 4nptA-2cwlA:undetectable | 4nptA-2cwlA:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d0o | DIOLDEHYDRATASE-REACTIVATING FACTOR LARGESUBUNIT (Klebsiellaoxytoca) |
PF08841(DDR) | 6 | ALA A 237ILE A 217ILE A 208THR A 97ILE A 93VAL A 254 | None | 1.29A | 4nptA-2d0oA:undetectable | 4nptA-2d0oA:11.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d16 | HYPOTHETICAL PROTEINPH1918 (Pyrococcushorikoshii) |
PF04008(Adenosine_kin) | 5 | ALA A 79ILE A 19GLY A 20ILE A 130VAL A 120 | NoneNoneNone NA A1001 (-4.8A)None | 1.04A | 4nptA-2d16A:undetectable | 4nptA-2d16A:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ekm | HYPOTHETICAL PROTEINST1511 (Sulfurisphaeratokodaii) |
PF04008(Adenosine_kin) | 5 | ALA A 80ILE A 20GLY A 21ILE A 131VAL A 121 | None | 0.99A | 4nptA-2ekmA:undetectable | 4nptA-2ekmA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2es9 | PUTATIVE CYTOPLASMICPROTEIN (Salmonellaenterica) |
PF08986(DUF1889) | 5 | ALA A 78ILE A 41GLY A 40ILE A 89VAL A 57 | None | 1.11A | 4nptA-2es9A:undetectable | 4nptA-2es9A:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2foi | ENOYL-ACYL CARRIERREDUCTASE (Plasmodiumfalciparum) |
PF13561(adh_short_C2) | 5 | ILE A 115GLY A 112ILE A 105ILE A 99VAL A 124 | None | 1.14A | 4nptA-2foiA:undetectable | 4nptA-2foiA:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jfd | FATTY ACID SYNTHASE (Homo sapiens) |
PF00698(Acyl_transf_1)PF16197(KAsynt_C_assoc) | 5 | ALA A 599ILE A 564GLY A 562ILE A 520VAL A 585 | None | 1.13A | 4nptA-2jfdA:undetectable | 4nptA-2jfdA:14.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o7q | BIFUNCTIONAL3-DEHYDROQUINATEDEHYDRATASE/SHIKIMATE DEHYDROGENASE (Arabidopsisthaliana) |
PF01487(DHquinase_I)PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 5 | ASN A 483ALA A 489GLY A 498ILE A 496ILE A 459 | SO4 A1402 (-4.0A)NoneNoneNoneNone | 1.15A | 4nptA-2o7qA:undetectable | 4nptA-2o7qA:12.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oox | HYPOTHETICAL PROTEINC1556.08C INCHROMOSOME I (Schizosaccharomycespombe) |
no annotation | 5 | ALA G 307ILE G 189GLY G 190ILE G 303ILE G 283 | AMP G 401 ( 4.8A)NoneAMP G 401 ( 4.5A)AMP G 401 (-4.0A)None | 1.17A | 4nptA-2ooxG:undetectable | 4nptA-2ooxG:15.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p38 | PROTEIN INVOLVED INRIBOSOMAL BIOGENESIS (Pyrococcusabyssi) |
PF03657(UPF0113) | 6 | ALA A 114ILE A 140GLY A 141ILE A 142ILE A 122VAL A 119 | None | 1.39A | 4nptA-2p38A:undetectable | 4nptA-2p38A:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xqr | INVERTASE INHIBITOR (Nicotianatabacum) |
PF04043(PMEI) | 5 | ALA B 100GLY B 106ILE B 80ILE B 142VAL B 143 | None | 1.10A | 4nptA-2xqrB:undetectable | 4nptA-2xqrB:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xz8 | PEPTIDOGLYCAN-RECOGNITION PROTEIN LF (Drosophilamelanogaster) |
no annotation | 5 | ALA A 312ILE A 289THR A 266ILE A 333VAL A 302 | None | 1.08A | 4nptA-2xz8A:undetectable | 4nptA-2xz8A:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a74 | LYSYL-TRNASYNTHETASE (Geobacillusstearothermophilus) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 5 | ASN A 440ALA A 443GLY A 206ILE A 228ILE A 386 | None | 1.10A | 4nptA-3a74A:undetectable | 4nptA-3a74A:11.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clk | TRANSCRIPTIONREGULATOR (Lactobacillusplantarum) |
PF13377(Peripla_BP_3) | 5 | ALA A 76ILE A 83GLY A 297ILE A 127VAL A 68 | None | 1.04A | 4nptA-3clkA:undetectable | 4nptA-3clkA:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d1c | FLAVIN-CONTAININGPUTATIVEMONOOXYGENASE (Staphylococcusaureus) |
PF13738(Pyr_redox_3) | 5 | ALA A 266ILE A 152GLY A 151ILE A 240ILE A 191 | UNL A 501 ( 4.7A)NoneNoneNoneNone | 1.13A | 4nptA-3d1cA:undetectable | 4nptA-3d1cA:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eoe | PYRUVATE KINASE (Toxoplasmagondii) |
PF00224(PK)PF02887(PK_C) | 5 | ALA A 272ILE A 256ILE A 310ILE A 239VAL A 236 | None | 1.11A | 4nptA-3eoeA:undetectable | 4nptA-3eoeA:10.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3epm | THIAMINEBIOSYNTHESIS PROTEINTHIC (Caulobactervibrioides) |
PF01964(ThiC_Rad_SAM)PF13667(ThiC-associated) | 5 | ALA A 504ILE A 465ILE A 460ILE A 216VAL A 214 | None | 0.98A | 4nptA-3epmA:undetectable | 4nptA-3epmA:10.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewd | ADENOSINE DEAMINASE (Plasmodiumvivax) |
PF00962(A_deaminase) | 5 | ILE A 170GLY A 171ILE A 179ILE A 93VAL A 89 | NoneNoneNoneNoneMCF A 372 ( 3.7A) | 1.10A | 4nptA-3ewdA:undetectable | 4nptA-3ewdA:15.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fed | GLUTAMATECARBOXYPEPTIDASE III (Homo sapiens) |
PF02225(PA)PF04253(TFR_dimer)PF04389(Peptidase_M28) | 5 | ALA A 210ILE A 215GLY A 214ILE A 213ILE A 184 | None | 1.13A | 4nptA-3fedA:undetectable | 4nptA-3fedA:9.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fj4 | MUCONATECYCLOISOMERASE (Pseudomonasprotegens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 113ILE A 309GLY A 310ILE A 276ILE A 73 | None | 1.12A | 4nptA-3fj4A:undetectable | 4nptA-3fj4A:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jyf | 2',3'-CYCLICNUCLEOTIDE2'-PHOSPHODIESTERASE/3'-NUCLEOTIDASEBIFUNCTIONALPERIPLASMIC PROTEIN (Klebsiellapneumoniae) |
PF00149(Metallophos) | 5 | ALA A 237ILE A 159GLY A 160ILE A 162VAL A 283 | None | 0.99A | 4nptA-3jyfA:undetectable | 4nptA-3jyfA:15.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l3b | ES1 FAMILY PROTEIN (Ehrlichiachaffeensis) |
PF01965(DJ-1_PfpI) | 5 | ILE A 207GLY A 206ILE A 178MET A 210ILE A 157 | None | 1.01A | 4nptA-3l3bA:undetectable | 4nptA-3l3bA:16.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lpe | PUTATIVETRANSCRIPTIONANTITERMINATIONPROTEIN NUSG (Methanocaldococcusjannaschii) |
PF03439(Spt5-NGN) | 5 | ALA A 47ILE A 33ILE A 76ILE A 66VAL A 53 | None | 1.02A | 4nptA-3lpeA:undetectable | 4nptA-3lpeA:27.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nlc | UNCHARACTERIZEDPROTEIN VP0956 (Vibrioparahaemolyticus) |
no annotation | 5 | ILE A 243GLY A 245ILE A 254ILE A 532VAL A 528 | None | 0.97A | 4nptA-3nlcA:undetectable | 4nptA-3nlcA:10.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3odh | OKRAI ENDONUCLEASE (Oceanobacterkriegii) |
PF02923(BamHI) | 5 | ALA A 165ILE A 124ILE A 112ILE A 18VAL A 15 | None | 1.15A | 4nptA-3odhA:undetectable | 4nptA-3odhA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3omn | CYTOCHROME COXIDASE, AA3 TYPE,SUBUNIT I (Rhodobactersphaeroides) |
PF00115(COX1) | 5 | ALA A 428ILE A 297GLY A 296ILE A 112VAL A 111 | NoneNoneNoneNoneHEA A 1 (-4.5A) | 1.09A | 4nptA-3omnA:undetectable | 4nptA-3omnA:11.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ovg | AMIDOHYDROLASE (Mycoplasmasynoviae) |
PF02126(PTE) | 5 | ALA A 83GLY A 90ILE A 57ILE A 94VAL A 9 | None | 1.09A | 4nptA-3ovgA:undetectable | 4nptA-3ovgA:16.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p3v | PTS SYSTEM,N-ACETYLGALACTOSAMINE-SPECIFIC IIBCOMPONENT (Streptococcuspyogenes) |
PF03830(PTSIIB_sorb) | 5 | ALA A 35ILE A 6ILE A 103ILE A 68VAL A 67 | None | 1.13A | 4nptA-3p3vA:undetectable | 4nptA-3p3vA:26.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pzl | AGMATINEUREOHYDROLASE (Thermoplasmavolcanium) |
PF00491(Arginase) | 5 | ALA A 130ILE A 42GLY A 121ILE A 270VAL A 107 | None | 1.16A | 4nptA-3pzlA:undetectable | 4nptA-3pzlA:15.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r1i | SHORT-CHAIN TYPEDEHYDROGENASE/REDUCTASE (Mycobacteriummarinum) |
PF13561(adh_short_C2) | 5 | ALA A 36ILE A 89GLY A 88MET A 134THR A 142 | None | 1.09A | 4nptA-3r1iA:undetectable | 4nptA-3r1iA:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r44 | FATTY ACYL COASYNTHETASE FADD13(FATTY-ACYL-COASYNTHETASE) (Mycobacteriumtuberculosis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | ILE A 430GLY A 431ILE A 440ILE A 418VAL A 445 | None | 1.14A | 4nptA-3r44A:undetectable | 4nptA-3r44A:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s5u | PUTATIVEUNCHARACTERIZEDPROTEIN (Enterococcusfaecalis) |
PF09711(Cas_Csn2) | 5 | ILE A 65ILE A 167THR A 152ILE A 185VAL A 181 | None | 1.05A | 4nptA-3s5uA:undetectable | 4nptA-3s5uA:14.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sjn | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Shewanellapealeana) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 44ILE A 100GLY A 279ILE A 55VAL A 51 | None | 1.08A | 4nptA-3sjnA:undetectable | 4nptA-3sjnA:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t8l | ADENINE DEAMINASE 2 (Agrobacteriumfabrum) |
PF01979(Amidohydro_1)PF13382(Adenine_deam_C) | 5 | ALA A 495ILE A 500GLY A 501MET A 390VAL A 484 | None | 1.16A | 4nptA-3t8lA:undetectable | 4nptA-3t8lA:10.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tbk | RIG-I HELICASEDOMAIN (Mus musculus) |
PF00271(Helicase_C)PF04851(ResIII) | 5 | ALA A 643ILE A 661GLY A 660ILE A 694THR A 698 | None | 1.10A | 4nptA-3tbkA:undetectable | 4nptA-3tbkA:12.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ALA A 28ILE A 47GLY A 48THR A 80VAL A 84 | 017 A 201 (-3.4A)017 A 202 (-3.6A)017 A 202 ( 4.6A)NoneNone | 0.59A | 4nptA-3u7sA:18.8 | 4nptA-3u7sA:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uko | ALCOHOLDEHYDROGENASECLASS-3 (Arabidopsisthaliana) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 12ILE A 358GLY A 356THR A 44ILE A 41 | None | 1.10A | 4nptA-3ukoA:undetectable | 4nptA-3ukoA:14.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrd | FLAVOCYTOCHROME CFLAVIN SUBUNIT (Thermochromatiumtepidum) |
PF07992(Pyr_redox_2)PF09242(FCSD-flav_bind) | 5 | ALA B 173ILE B 49ILE B 340ILE B 187VAL B 185 | None | 1.06A | 4nptA-3vrdB:undetectable | 4nptA-3vrdB:12.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ain | GLYCINE BETAINETRANSPORTER BETP (Corynebacteriumglutamicum) |
PF02028(BCCT) | 5 | ALA A 525ILE A 240MET A 476THR A 499ILE A 502 | None | 1.05A | 4nptA-4ainA:undetectable | 4nptA-4ainA:11.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ap8 | MOLYBDOPTERINSYNTHASE CATALYTICSUBUNIT (Homo sapiens) |
PF02391(MoaE) | 5 | ALA A 120ILE A 110ILE A 155ILE A 71VAL A 63 | None | 0.96A | 4nptA-4ap8A:undetectable | 4nptA-4ap8A:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hpz | DTALE2 (Xanthomonas) |
PF03377(TAL_effector) | 5 | ALA A 240GLY A 229ILE A 225ILE A 263VAL A 272 | None | 1.12A | 4nptA-4hpzA:undetectable | 4nptA-4hpzA:14.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ixo | NIFS-LIKE PROTEIN (Rickettsiaafricae) |
PF00266(Aminotran_5) | 5 | ILE A 197GLY A 198ILE A 12ILE A 237VAL A 47 | LLP A 196 ( 4.0A)NoneNoneNoneNone | 1.07A | 4nptA-4ixoA:undetectable | 4nptA-4ixoA:13.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kit | PRE-MRNA-PROCESSING-SPLICING FACTOR 8 (Homo sapiens) |
PF01398(JAB)PF08084(PROCT) | 5 | ALA C2125GLY C2176ILE C2212THR C2195VAL C2157 | None | 1.15A | 4nptA-4kitC:undetectable | 4nptA-4kitC:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpu | ELECTRON TRANSFERFLAVOPROTEIN ALPHASUBUNITELECTRON TRANSFERFLAVOPROTEINALPHA/BETA-SUBUNIT (Acidaminococcusfermentans) |
PF00766(ETF_alpha)PF01012(ETF) | 5 | ASN B 35ALA B 120GLY A 150ILE B 33VAL B 10 | FAD B 301 (-4.3A)FAD B 301 (-3.3A)NoneNoneNone | 1.08A | 4nptA-4kpuB:undetectable | 4nptA-4kpuB:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l22 | PHOSPHORYLASE (Streptococcusmutans) |
PF00343(Phosphorylase) | 5 | ASN A 734ILE A 638GLY A 618MET A 620VAL A 631 | None | 1.08A | 4nptA-4l22A:undetectable | 4nptA-4l22A:8.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ALA A 307ILE A 375ILE A 312MET A 377ILE A 322 | NoneNoneNoneNoneNAD A 503 (-4.7A) | 1.10A | 4nptA-4lvcA:undetectable | 4nptA-4lvcA:12.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ni5 | OXIDOREDUCTASE,SHORT-CHAINDEHYDROGENASE/REDUCTASE FAMILY PROTEIN (Brucella suis) |
PF13561(adh_short_C2) | 5 | ALA A 87ILE A 17GLY A 18ILE A 34ILE A 111 | None | 1.15A | 4nptA-4ni5A:undetectable | 4nptA-4ni5A:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4on9 | PROBABLEATP-DEPENDENT RNAHELICASE DDX58 (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | ALA A 642ILE A 660GLY A 659ILE A 693THR A 697 | None | 1.07A | 4nptA-4on9A:undetectable | 4nptA-4on9A:10.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pvv | ADENOSINE KINASE (Mycobacteriumtuberculosis) |
PF00294(PfkB) | 5 | ALA A 4ILE A 136GLY A 137ILE A 127VAL A 67 | None | 1.12A | 4nptA-4pvvA:undetectable | 4nptA-4pvvA:13.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qiw | DNA-DIRECTED RNAPOLYMERASE (Thermococcuskodakarensis) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 5 | ALA B 324GLY B 213ILE B 214ILE B 243VAL B 247 | None | 1.11A | 4nptA-4qiwB:undetectable | 4nptA-4qiwB:6.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rgq | GLYCEROL-1-PHOSPHATEDEHYDROGENASE (Methanocaldococcusjannaschii) |
PF13685(Fe-ADH_2) | 5 | ALA A 129ILE A 81GLY A 74ILE A 73VAL A 206 | None | 1.07A | 4nptA-4rgqA:undetectable | 4nptA-4rgqA:13.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rmf | ASPARTATE--TRNA(ASP/ASN) LIGASE (Mycolicibacteriumsmegmatis) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon)PF02938(GAD) | 5 | ALA A 7ILE A 86GLY A 89ILE A 91ILE A 37 | None | 1.14A | 4nptA-4rmfA:undetectable | 4nptA-4rmfA:11.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rtb | HYDG PROTEIN (Carboxydothermushydrogenoformans) |
PF04055(Radical_SAM)PF06968(BATS) | 5 | ILE A 245ILE A 289MET A 296ILE A 47VAL A 16 | None | 1.17A | 4nptA-4rtbA:undetectable | 4nptA-4rtbA:14.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w7h | CARBONYL REDUCTASE (Sphingomonassp. A1) |
PF13561(adh_short_C2) | 5 | ALA A 231ILE A 19GLY A 20ILE A 12ILE A 191 | None | 1.01A | 4nptA-4w7hA:undetectable | 4nptA-4w7hA:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xfe | TRAP DICARBOXYLATETRANSPORTER SUBUNITDCTP (Pseudomonasputida) |
PF03480(DctP) | 5 | ALA A 182ILE A 177GLY A 187ILE A 168VAL A 304 | None | 0.91A | 4nptA-4xfeA:undetectable | 4nptA-4xfeA:15.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynn | PROTEASE DO (Legionellapneumophila) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | ASN A 79ALA A 190ILE A 21ILE A 83VAL A 82 | None | 1.06A | 4nptA-4ynnA:2.1 | 4nptA-4ynnA:15.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yry | DIHYDROOROTATEDEHYDROGENASE B(NAD(+)), ELECTRONTRANSFER SUBUNITHOMOLOGDIHYDROPYRIMIDINEDEHYDROGENASESUBUNIT A (Thermotogamaritima) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6)PF07992(Pyr_redox_2)PF10418(DHODB_Fe-S_bind)PF14691(Fer4_20) | 5 | ILE B 243GLY B 242ILE A 236ILE B 388VAL B 387 | None | 1.12A | 4nptA-4yryB:undetectable | 4nptA-4yryB:11.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ywo | MERCURIC REDUCTASE (Metallosphaerasedula) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ALA A 187ILE A 166GLY A 167THR A 237VAL A 242 | None | 0.93A | 4nptA-4ywoA:undetectable | 4nptA-4ywoA:13.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zfq | L,D-TRANSPEPTIDASE 5 (Mycobacteriumtuberculosis) |
PF03734(YkuD) | 5 | ALA A 375GLY A 171ILE A 172ILE A 334VAL A 332 | None | 0.99A | 4nptA-4zfqA:undetectable | 4nptA-4zfqA:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zn1 | TRANSCRIPTIONELONGATION FACTORSPT5 (Methanocaldococcusjannaschii) |
PF00467(KOW)PF03439(Spt5-NGN) | 5 | ALA A 47ILE A 33ILE A 76ILE A 66VAL A 53 | None | 0.93A | 4nptA-4zn1A:undetectable | 4nptA-4zn1A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a3y | THERMOLYSIN (Bacillusthermoproteolyticus) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 5 | ILE A 39ILE A 20THR A 80ILE A 137VAL A 140 | None | 1.15A | 4nptA-5a3yA:undetectable | 4nptA-5a3yA:13.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5brr | TISSUE-TYPEPLASMINOGENACTIVATOR (Homo sapiens) |
PF00089(Trypsin) | 5 | ALA E 56ILE E 33GLY E 44ILE E 45ILE E 89 | None | 1.08A | 4nptA-5brrE:undetectable | 4nptA-5brrE:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5buk | FADH2-DEPENDENTHALOGENASE (Streptomycessp. CNQ-418) |
PF04820(Trp_halogenase) | 5 | ALA A 31ILE A 10GLY A 11THR A 160VAL A 169 | NoneFAD A 501 (-4.7A)FAD A 501 (-3.3A)NoneNone | 1.03A | 4nptA-5bukA:undetectable | 4nptA-5bukA:12.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwb | DESIGNED HELICALREPEAT PROTEIN (syntheticconstruct) |
no annotation | 5 | ALA A 70ILE A 63ILE A 117ILE A 31VAL A 18 | None | 1.12A | 4nptA-5cwbA:undetectable | 4nptA-5cwbA:15.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dot | CARBAMOYL-PHOSPHATESYNTHASE [AMMONIA],MITOCHONDRIAL (Homo sapiens) |
PF00117(GATase)PF00988(CPSase_sm_chain)PF02142(MGS)PF02786(CPSase_L_D2)PF02787(CPSase_L_D3) | 5 | ILE A 227GLY A 226ILE A 201ILE A 259VAL A 221 | NoneEDO A1606 ( 4.1A)NoneNoneNone | 1.04A | 4nptA-5dotA:undetectable | 4nptA-5dotA:5.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e6k | POLYKETIDE SYNTHASEPKSL (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | ALA A 405ILE A 258GLY A 260ILE A 287VAL A 357 | None | 1.13A | 4nptA-5e6kA:undetectable | 4nptA-5e6kA:13.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eny | POLYKETIDE SYNTHASEPKSL (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | ALA A 405ILE A 258GLY A 260ILE A 287VAL A 357 | None | 1.13A | 4nptA-5enyA:undetectable | 4nptA-5enyA:11.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eqv | BIFUNCTIONAL2',3'-CYCLICNUCLEOTIDE2'-PHOSPHODIESTERASE/3'-NUCLEOTIDASEPERIPLASMICPRECURSOR PROTEIN (Yersinia pestis) |
PF00149(Metallophos) | 5 | ALA A 260ILE A 182GLY A 183ILE A 185VAL A 306 | None | 0.98A | 4nptA-5eqvA:undetectable | 4nptA-5eqvA:13.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fxn | THERMOLYSIN (Bacillusthermoproteolyticus) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 5 | ILE A 39ILE A 20THR A 80ILE A 137VAL A 140 | None | 1.15A | 4nptA-5fxnA:undetectable | 4nptA-5fxnA:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hd2 | PARASPORAL CRYSTALPROTEIN (Bacillusthuringiensis) |
PF03318(ETX_MTX2) | 5 | ASN A 296GLY A 289THR A 261ILE A 294VAL A 297 | None | 1.09A | 4nptA-5hd2A:undetectable | 4nptA-5hd2A:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jvb | PHOSPHONATE ABCTRANSPORTER,PERIPLASMICPHOSPHONATE-BINDINGPROTEIN (Trichodesmiumerythraeum) |
no annotation | 5 | ALA A 166ILE A 105GLY A 106ILE A 112VAL A 157 | None | 1.11A | 4nptA-5jvbA:undetectable | 4nptA-5jvbA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jx5 | GLUCANASE (Orpinomyces sp.Y102) |
PF01341(Glyco_hydro_6) | 5 | ASN A 342ALA A 301ILE A 250GLY A 251THR A 325 | NoneNoneEDO A 507 (-3.7A)EDO A 507 (-4.2A)None | 1.12A | 4nptA-5jx5A:undetectable | 4nptA-5jx5A:15.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kpg | PAVINEN-METHYLTRANSFERASE (Thalictrumflavum) |
PF02353(CMAS) | 5 | ALA A 200ILE A 157GLY A 156ILE A 221VAL A 217 | None | 1.15A | 4nptA-5kpgA:undetectable | 4nptA-5kpgA:13.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mpo | MOLYBDOPTERINSYNTHASE CATALYTICSUBUNIT (Homo sapiens) |
PF02391(MoaE) | 5 | ALA C 120ILE C 110ILE C 155ILE C 71VAL C 63 | None | 0.96A | 4nptA-5mpoC:undetectable | 4nptA-5mpoC:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5te1 | ATP-CITRATE SYNTHASE (Homo sapiens) |
PF00549(Ligase_CoA)PF02629(CoA_binding)PF16114(Citrate_bind) | 5 | ILE A 620GLY A 694ILE A 687ILE A 570VAL A 568 | None | 1.13A | 4nptA-5te1A:undetectable | 4nptA-5te1A:9.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ydg | MULTIPLE ORGANELLARRNA EDITING FACTOR2, CHLOROPLASTIC (Arabidopsisthaliana) |
no annotation | 5 | ALA A 122ILE A 89GLY A 138THR A 145VAL A 116 | None | 1.16A | 4nptA-5ydgA:undetectable | 4nptA-5ydgA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zqz | TRIFUNCTIONAL ENZYMESUBUNIT ALPHA,MITOCHONDRIAL (Homo sapiens) |
no annotation | 5 | ALA A 244GLY A 250ILE A 256ILE A 137VAL A 89 | None | 1.11A | 4nptA-5zqzA:undetectable | 4nptA-5zqzA:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ao5 | SERINE/THREONINE-PROTEIN KINASE 3 (Homo sapiens) |
no annotation | 5 | ALA A 160ILE A 123ILE A 278THR A 210ILE A 147 | None | 1.14A | 4nptA-6ao5A:undetectable | 4nptA-6ao5A:14.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bhu | MULTIDRUGRESISTANCE-ASSOCIATED PROTEIN 1 (Bos taurus) |
no annotation | 5 | GLY A1323ILE A1483THR A1479ILE A1449VAL A1292 | None | 1.04A | 4nptA-6bhuA:undetectable | 4nptA-6bhuA:0.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfw | MONOVALENT CATION/H+ANTIPORTER SUBUNIT D (Pyrococcusfuriosus) |
no annotation | 5 | ALA H 264GLY H 258ILE H 129THR H 347ILE H 344 | None | 1.09A | 4nptA-6cfwH:undetectable | 4nptA-6cfwH:21.57 |