SIMILAR PATTERNS OF AMINO ACIDS FOR 4NPT_A_017A401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aec ACTINIDIN

(Actinidia
chinensis)
PF00112
(Peptidase_C1)
5 ALA A 127
ILE A 166
GLY A 168
THR A  33
ILE A  37
None
1.09A 4nptA-1aecA:
0.7
4nptA-1aecA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE


(Bacillus
subtilis)
PF00156
(Pribosyltran)
PF13522
(GATase_6)
5 ALA A 287
GLY A 424
ILE A 425
ILE A 373
VAL A 344
None
1.15A 4nptA-1ao0A:
0.0
4nptA-1ao0A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME


(Pseudomonas
putida)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ALA A 111
ILE A 307
GLY A 308
ILE A 274
ILE A  71
None
1.11A 4nptA-1bkhA:
0.0
4nptA-1bkhA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)


(Allochromatium
vinosum)
PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind)
5 ALA A 173
ILE A  49
ILE A 340
ILE A 187
VAL A 185
None
1.04A 4nptA-1fcdA:
0.0
4nptA-1fcdA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gom ENDO-1,4-BETA-XYLANA
SE


(Thermoascus
aurantiacus)
PF00331
(Glyco_hydro_10)
5 ALA A 254
ILE A 264
GLY A 263
THR A 208
VAL A 218
None
1.09A 4nptA-1gomA:
undetectable
4nptA-1gomA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyg L-LACTATE/MALATE
DEHYDROGENASE


(Methanocaldococcus
jannaschii)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ALA A 255
ILE A 175
GLY A 176
ILE A 303
VAL A 283
None
1.05A 4nptA-1hygA:
0.0
4nptA-1hygA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0r NUSA

(Mycobacterium
tuberculosis)
PF08529
(NusA_N)
PF13184
(KH_5)
5 ALA A 231
ILE A 236
GLY A 237
ILE A 207
VAL A 222
None
0.99A 4nptA-1k0rA:
undetectable
4nptA-1k0rA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4v PHOSPHORIBOSYLAMINOI
MIDAZOLE MUTASE PURE


(Thermotoga
maritima)
PF00731
(AIRC)
5 ALA A 125
ILE A 136
GLY A 130
ILE A 131
ILE A  57
None
1.17A 4nptA-1o4vA:
0.0
4nptA-1o4vA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE


(Escherichia
coli)
PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2)
5 ALA A 657
GLY A 410
ILE A 414
THR A 427
ILE A 335
FAD  A 701 (-3.1A)
FAD  A 701 (-2.9A)
FAD  A 701 (-3.9A)
None
SF4  A 700 (-4.8A)
1.14A 4nptA-1ps9A:
0.0
4nptA-1ps9A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1


(Rhodospirillum
rubrum)
PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N)
5 ALA A 196
GLY A 152
ILE A 150
ILE A 188
VAL A 198
None
1.05A 4nptA-1ptjA:
undetectable
4nptA-1ptjA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)


(Synechococcus
elongatus)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 ALA A 389
GLY A 442
ILE A 444
ILE A 382
VAL A 332
None
1.16A 4nptA-1rblA:
undetectable
4nptA-1rblA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT


(Pseudomonas
putida)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
5 GLY B 378
ILE B 380
THR B 321
ILE B 367
VAL B 335
None
1.15A 4nptA-1t3qB:
undetectable
4nptA-1t3qB:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE


(Bacillus
subtilis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ALA A 106
GLY A 274
MET A 270
ILE A  66
VAL A  34
None
1.10A 4nptA-1tkkA:
undetectable
4nptA-1tkkA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE


(Pseudoalteromonas
sp. AS-11)
PF00082
(Peptidase_S8)
PF02225
(PA)
5 ALA A 123
ILE A  95
GLY A  47
ILE A 114
VAL A 126
None
1.03A 4nptA-1v6cA:
undetectable
4nptA-1v6cA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdw HYPOTHETICAL PROTEIN
PH1897


(Pyrococcus
horikoshii)
PF00459
(Inositol_P)
5 ALA A 214
ILE A 208
GLY A 205
ILE A 202
VAL A 142
None
1.15A 4nptA-1vdwA:
undetectable
4nptA-1vdwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC


(Homo sapiens)
PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C)
5 ALA A  83
ILE A 142
GLY A 115
ILE A 116
ILE A 101
None
1.12A 4nptA-1wpqA:
undetectable
4nptA-1wpqA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA


(Mycobacterium
tuberculosis)
PF13184
(KH_5)
5 ALA A 231
ILE A 236
GLY A 237
ILE A 207
VAL A 222
None
G  B   1 ( 4.0A)
None
None
None
0.97A 4nptA-2asbA:
undetectable
4nptA-2asbA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE


(Corynebacterium
callunae)
PF00343
(Phosphorylase)
5 ASN A 764
ILE A 664
GLY A 644
MET A 646
VAL A 657
None
1.09A 4nptA-2c4mA:
undetectable
4nptA-2c4mA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cf5 CINNAMYL ALCOHOL
DEHYDROGENASE


(Arabidopsis
thaliana)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 159
ILE A  41
GLY A  73
ILE A  90
VAL A 347
None
0.94A 4nptA-2cf5A:
undetectable
4nptA-2cf5A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE


(Anopheles
gambiae)
PF00266
(Aminotran_5)
5 ALA A 180
ILE A  63
ILE A 284
THR A  66
VAL A 199
None
1.16A 4nptA-2ch1A:
undetectable
4nptA-2ch1A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwl MANGANESE-FREE
PSEUDOCATALASE


(Thermus
thermophilus)
PF05067
(Mn_catalase)
5 ALA A  28
ILE A  81
ILE A  74
ILE A 178
VAL A 165
None
1.15A 4nptA-2cwlA:
undetectable
4nptA-2cwlA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT


(Klebsiella
oxytoca)
PF08841
(DDR)
6 ALA A 237
ILE A 217
ILE A 208
THR A  97
ILE A  93
VAL A 254
None
1.29A 4nptA-2d0oA:
undetectable
4nptA-2d0oA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d16 HYPOTHETICAL PROTEIN
PH1918


(Pyrococcus
horikoshii)
PF04008
(Adenosine_kin)
5 ALA A  79
ILE A  19
GLY A  20
ILE A 130
VAL A 120
None
None
None
NA  A1001 (-4.8A)
None
1.04A 4nptA-2d16A:
undetectable
4nptA-2d16A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekm HYPOTHETICAL PROTEIN
ST1511


(Sulfurisphaera
tokodaii)
PF04008
(Adenosine_kin)
5 ALA A  80
ILE A  20
GLY A  21
ILE A 131
VAL A 121
None
0.99A 4nptA-2ekmA:
undetectable
4nptA-2ekmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es9 PUTATIVE CYTOPLASMIC
PROTEIN


(Salmonella
enterica)
PF08986
(DUF1889)
5 ALA A  78
ILE A  41
GLY A  40
ILE A  89
VAL A  57
None
1.11A 4nptA-2es9A:
undetectable
4nptA-2es9A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2foi ENOYL-ACYL CARRIER
REDUCTASE


(Plasmodium
falciparum)
PF13561
(adh_short_C2)
5 ILE A 115
GLY A 112
ILE A 105
ILE A  99
VAL A 124
None
1.14A 4nptA-2foiA:
undetectable
4nptA-2foiA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfd FATTY ACID SYNTHASE

(Homo sapiens)
PF00698
(Acyl_transf_1)
PF16197
(KAsynt_C_assoc)
5 ALA A 599
ILE A 564
GLY A 562
ILE A 520
VAL A 585
None
1.13A 4nptA-2jfdA:
undetectable
4nptA-2jfdA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE


(Arabidopsis
thaliana)
PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
5 ASN A 483
ALA A 489
GLY A 498
ILE A 496
ILE A 459
SO4  A1402 (-4.0A)
None
None
None
None
1.15A 4nptA-2o7qA:
undetectable
4nptA-2o7qA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I


(Schizosaccharomyces
pombe)
no annotation 5 ALA G 307
ILE G 189
GLY G 190
ILE G 303
ILE G 283
AMP  G 401 ( 4.8A)
None
AMP  G 401 ( 4.5A)
AMP  G 401 (-4.0A)
None
1.17A 4nptA-2ooxG:
undetectable
4nptA-2ooxG:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p38 PROTEIN INVOLVED IN
RIBOSOMAL BIOGENESIS


(Pyrococcus
abyssi)
PF03657
(UPF0113)
6 ALA A 114
ILE A 140
GLY A 141
ILE A 142
ILE A 122
VAL A 119
None
1.39A 4nptA-2p38A:
undetectable
4nptA-2p38A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqr INVERTASE INHIBITOR

(Nicotiana
tabacum)
PF04043
(PMEI)
5 ALA B 100
GLY B 106
ILE B  80
ILE B 142
VAL B 143
None
1.10A 4nptA-2xqrB:
undetectable
4nptA-2xqrB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz8 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF


(Drosophila
melanogaster)
no annotation 5 ALA A 312
ILE A 289
THR A 266
ILE A 333
VAL A 302
None
1.08A 4nptA-2xz8A:
undetectable
4nptA-2xz8A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a74 LYSYL-TRNA
SYNTHETASE


(Geobacillus
stearothermophilus)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
5 ASN A 440
ALA A 443
GLY A 206
ILE A 228
ILE A 386
None
1.10A 4nptA-3a74A:
undetectable
4nptA-3a74A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clk TRANSCRIPTION
REGULATOR


(Lactobacillus
plantarum)
PF13377
(Peripla_BP_3)
5 ALA A  76
ILE A  83
GLY A 297
ILE A 127
VAL A  68
None
1.04A 4nptA-3clkA:
undetectable
4nptA-3clkA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE


(Staphylococcus
aureus)
PF13738
(Pyr_redox_3)
5 ALA A 266
ILE A 152
GLY A 151
ILE A 240
ILE A 191
UNL  A 501 ( 4.7A)
None
None
None
None
1.13A 4nptA-3d1cA:
undetectable
4nptA-3d1cA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoe PYRUVATE KINASE

(Toxoplasma
gondii)
PF00224
(PK)
PF02887
(PK_C)
5 ALA A 272
ILE A 256
ILE A 310
ILE A 239
VAL A 236
None
1.11A 4nptA-3eoeA:
undetectable
4nptA-3eoeA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epm THIAMINE
BIOSYNTHESIS PROTEIN
THIC


(Caulobacter
vibrioides)
PF01964
(ThiC_Rad_SAM)
PF13667
(ThiC-associated)
5 ALA A 504
ILE A 465
ILE A 460
ILE A 216
VAL A 214
None
0.98A 4nptA-3epmA:
undetectable
4nptA-3epmA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax)
PF00962
(A_deaminase)
5 ILE A 170
GLY A 171
ILE A 179
ILE A  93
VAL A  89
None
None
None
None
MCF  A 372 ( 3.7A)
1.10A 4nptA-3ewdA:
undetectable
4nptA-3ewdA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III


(Homo sapiens)
PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28)
5 ALA A 210
ILE A 215
GLY A 214
ILE A 213
ILE A 184
None
1.13A 4nptA-3fedA:
undetectable
4nptA-3fedA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE


(Pseudomonas
protegens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ALA A 113
ILE A 309
GLY A 310
ILE A 276
ILE A  73
None
1.12A 4nptA-3fj4A:
undetectable
4nptA-3fj4A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN


(Klebsiella
pneumoniae)
PF00149
(Metallophos)
5 ALA A 237
ILE A 159
GLY A 160
ILE A 162
VAL A 283
None
0.99A 4nptA-3jyfA:
undetectable
4nptA-3jyfA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3b ES1 FAMILY PROTEIN

(Ehrlichia
chaffeensis)
PF01965
(DJ-1_PfpI)
5 ILE A 207
GLY A 206
ILE A 178
MET A 210
ILE A 157
None
1.01A 4nptA-3l3bA:
undetectable
4nptA-3l3bA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpe PUTATIVE
TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG


(Methanocaldococcus
jannaschii)
PF03439
(Spt5-NGN)
5 ALA A  47
ILE A  33
ILE A  76
ILE A  66
VAL A  53
None
1.02A 4nptA-3lpeA:
undetectable
4nptA-3lpeA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956


(Vibrio
parahaemolyticus)
no annotation 5 ILE A 243
GLY A 245
ILE A 254
ILE A 532
VAL A 528
None
0.97A 4nptA-3nlcA:
undetectable
4nptA-3nlcA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odh OKRAI ENDONUCLEASE

(Oceanobacter
kriegii)
PF02923
(BamHI)
5 ALA A 165
ILE A 124
ILE A 112
ILE A  18
VAL A  15
None
1.15A 4nptA-3odhA:
undetectable
4nptA-3odhA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I


(Rhodobacter
sphaeroides)
PF00115
(COX1)
5 ALA A 428
ILE A 297
GLY A 296
ILE A 112
VAL A 111
None
None
None
None
HEA  A   1 (-4.5A)
1.09A 4nptA-3omnA:
undetectable
4nptA-3omnA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovg AMIDOHYDROLASE

(Mycoplasma
synoviae)
PF02126
(PTE)
5 ALA A  83
GLY A  90
ILE A  57
ILE A  94
VAL A   9
None
1.09A 4nptA-3ovgA:
undetectable
4nptA-3ovgA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3v PTS SYSTEM,
N-ACETYLGALACTOSAMIN
E-SPECIFIC IIB
COMPONENT


(Streptococcus
pyogenes)
PF03830
(PTSIIB_sorb)
5 ALA A  35
ILE A   6
ILE A 103
ILE A  68
VAL A  67
None
1.13A 4nptA-3p3vA:
undetectable
4nptA-3p3vA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzl AGMATINE
UREOHYDROLASE


(Thermoplasma
volcanium)
PF00491
(Arginase)
5 ALA A 130
ILE A  42
GLY A 121
ILE A 270
VAL A 107
None
1.16A 4nptA-3pzlA:
undetectable
4nptA-3pzlA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r1i SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE


(Mycobacterium
marinum)
PF13561
(adh_short_C2)
5 ALA A  36
ILE A  89
GLY A  88
MET A 134
THR A 142
None
1.09A 4nptA-3r1iA:
undetectable
4nptA-3r1iA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)


(Mycobacterium
tuberculosis)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 ILE A 430
GLY A 431
ILE A 440
ILE A 418
VAL A 445
None
1.14A 4nptA-3r44A:
undetectable
4nptA-3r44A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5u PUTATIVE
UNCHARACTERIZED
PROTEIN


(Enterococcus
faecalis)
PF09711
(Cas_Csn2)
5 ILE A  65
ILE A 167
THR A 152
ILE A 185
VAL A 181
None
1.05A 4nptA-3s5uA:
undetectable
4nptA-3s5uA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Shewanella
pealeana)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ALA A  44
ILE A 100
GLY A 279
ILE A  55
VAL A  51
None
1.08A 4nptA-3sjnA:
undetectable
4nptA-3sjnA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum)
PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C)
5 ALA A 495
ILE A 500
GLY A 501
MET A 390
VAL A 484
None
1.16A 4nptA-3t8lA:
undetectable
4nptA-3t8lA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN


(Mus musculus)
PF00271
(Helicase_C)
PF04851
(ResIII)
5 ALA A 643
ILE A 661
GLY A 660
ILE A 694
THR A 698
None
1.10A 4nptA-3tbkA:
undetectable
4nptA-3tbkA:
12.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u7s POL POLYPROTEIN

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ALA A  28
ILE A  47
GLY A  48
THR A  80
VAL A  84
017  A 201 (-3.4A)
017  A 202 (-3.6A)
017  A 202 ( 4.6A)
None
None
0.59A 4nptA-3u7sA:
18.8
4nptA-3u7sA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uko ALCOHOL
DEHYDROGENASE
CLASS-3


(Arabidopsis
thaliana)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A  12
ILE A 358
GLY A 356
THR A  44
ILE A  41
None
1.10A 4nptA-3ukoA:
undetectable
4nptA-3ukoA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT


(Thermochromatium
tepidum)
PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind)
5 ALA B 173
ILE B  49
ILE B 340
ILE B 187
VAL B 185
None
1.06A 4nptA-3vrdB:
undetectable
4nptA-3vrdB:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP


(Corynebacterium
glutamicum)
PF02028
(BCCT)
5 ALA A 525
ILE A 240
MET A 476
THR A 499
ILE A 502
None
1.05A 4nptA-4ainA:
undetectable
4nptA-4ainA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap8 MOLYBDOPTERIN
SYNTHASE CATALYTIC
SUBUNIT


(Homo sapiens)
PF02391
(MoaE)
5 ALA A 120
ILE A 110
ILE A 155
ILE A  71
VAL A  63
None
0.96A 4nptA-4ap8A:
undetectable
4nptA-4ap8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpz DTALE2

(Xanthomonas)
PF03377
(TAL_effector)
5 ALA A 240
GLY A 229
ILE A 225
ILE A 263
VAL A 272
None
1.12A 4nptA-4hpzA:
undetectable
4nptA-4hpzA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae)
PF00266
(Aminotran_5)
5 ILE A 197
GLY A 198
ILE A  12
ILE A 237
VAL A  47
LLP  A 196 ( 4.0A)
None
None
None
None
1.07A 4nptA-4ixoA:
undetectable
4nptA-4ixoA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kit PRE-MRNA-PROCESSING-
SPLICING FACTOR 8


(Homo sapiens)
PF01398
(JAB)
PF08084
(PROCT)
5 ALA C2125
GLY C2176
ILE C2212
THR C2195
VAL C2157
None
1.15A 4nptA-4kitC:
undetectable
4nptA-4kitC:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT


(Acidaminococcus
fermentans)
PF00766
(ETF_alpha)
PF01012
(ETF)
5 ASN B  35
ALA B 120
GLY A 150
ILE B  33
VAL B  10
FAD  B 301 (-4.3A)
FAD  B 301 (-3.3A)
None
None
None
1.08A 4nptA-4kpuB:
undetectable
4nptA-4kpuB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans)
PF00343
(Phosphorylase)
5 ASN A 734
ILE A 638
GLY A 618
MET A 620
VAL A 631
None
1.08A 4nptA-4l22A:
undetectable
4nptA-4l22A:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)


(Bradyrhizobium
elkanii)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 ALA A 307
ILE A 375
ILE A 312
MET A 377
ILE A 322
None
None
None
None
NAD  A 503 (-4.7A)
1.10A 4nptA-4lvcA:
undetectable
4nptA-4lvcA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN


(Brucella suis)
PF13561
(adh_short_C2)
5 ALA A  87
ILE A  17
GLY A  18
ILE A  34
ILE A 111
None
1.15A 4nptA-4ni5A:
undetectable
4nptA-4ni5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 ALA A 642
ILE A 660
GLY A 659
ILE A 693
THR A 697
None
1.07A 4nptA-4on9A:
undetectable
4nptA-4on9A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis)
PF00294
(PfkB)
5 ALA A   4
ILE A 136
GLY A 137
ILE A 127
VAL A  67
None
1.12A 4nptA-4pvvA:
undetectable
4nptA-4pvvA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE


(Thermococcus
kodakarensis)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
5 ALA B 324
GLY B 213
ILE B 214
ILE B 243
VAL B 247
None
1.11A 4nptA-4qiwB:
undetectable
4nptA-4qiwB:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE


(Methanocaldococcus
jannaschii)
PF13685
(Fe-ADH_2)
5 ALA A 129
ILE A  81
GLY A  74
ILE A  73
VAL A 206
None
1.07A 4nptA-4rgqA:
undetectable
4nptA-4rgqA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE


(Mycolicibacterium
smegmatis)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD)
5 ALA A   7
ILE A  86
GLY A  89
ILE A  91
ILE A  37
None
1.14A 4nptA-4rmfA:
undetectable
4nptA-4rmfA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rtb HYDG PROTEIN

(Carboxydothermus
hydrogenoformans)
PF04055
(Radical_SAM)
PF06968
(BATS)
5 ILE A 245
ILE A 289
MET A 296
ILE A  47
VAL A  16
None
1.17A 4nptA-4rtbA:
undetectable
4nptA-4rtbA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7h CARBONYL REDUCTASE

(Sphingomonas
sp. A1)
PF13561
(adh_short_C2)
5 ALA A 231
ILE A  19
GLY A  20
ILE A  12
ILE A 191
None
1.01A 4nptA-4w7hA:
undetectable
4nptA-4w7hA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP


(Pseudomonas
putida)
PF03480
(DctP)
5 ALA A 182
ILE A 177
GLY A 187
ILE A 168
VAL A 304
None
0.91A 4nptA-4xfeA:
undetectable
4nptA-4xfeA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynn PROTEASE DO

(Legionella
pneumophila)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
5 ASN A  79
ALA A 190
ILE A  21
ILE A  83
VAL A  82
None
1.06A 4nptA-4ynnA:
2.1
4nptA-4ynnA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A


(Thermotoga
maritima)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
PF07992
(Pyr_redox_2)
PF10418
(DHODB_Fe-S_bind)
PF14691
(Fer4_20)
5 ILE B 243
GLY B 242
ILE A 236
ILE B 388
VAL B 387
None
1.12A 4nptA-4yryB:
undetectable
4nptA-4yryB:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywo MERCURIC REDUCTASE

(Metallosphaera
sedula)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A 187
ILE A 166
GLY A 167
THR A 237
VAL A 242
None
0.93A 4nptA-4ywoA:
undetectable
4nptA-4ywoA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfq L,D-TRANSPEPTIDASE 5

(Mycobacterium
tuberculosis)
PF03734
(YkuD)
5 ALA A 375
GLY A 171
ILE A 172
ILE A 334
VAL A 332
None
0.99A 4nptA-4zfqA:
undetectable
4nptA-4zfqA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn1 TRANSCRIPTION
ELONGATION FACTOR
SPT5


(Methanocaldococcus
jannaschii)
PF00467
(KOW)
PF03439
(Spt5-NGN)
5 ALA A  47
ILE A  33
ILE A  76
ILE A  66
VAL A  53
None
0.93A 4nptA-4zn1A:
undetectable
4nptA-4zn1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3y THERMOLYSIN

(Bacillus
thermoproteolyticus)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
5 ILE A  39
ILE A  20
THR A  80
ILE A 137
VAL A 140
None
1.15A 4nptA-5a3yA:
undetectable
4nptA-5a3yA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR


(Homo sapiens)
PF00089
(Trypsin)
5 ALA E  56
ILE E  33
GLY E  44
ILE E  45
ILE E  89
None
1.08A 4nptA-5brrE:
undetectable
4nptA-5brrE:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buk FADH2-DEPENDENT
HALOGENASE


(Streptomyces
sp. CNQ-418)
PF04820
(Trp_halogenase)
5 ALA A  31
ILE A  10
GLY A  11
THR A 160
VAL A 169
None
FAD  A 501 (-4.7A)
FAD  A 501 (-3.3A)
None
None
1.03A 4nptA-5bukA:
undetectable
4nptA-5bukA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwb DESIGNED HELICAL
REPEAT PROTEIN


(synthetic
construct)
no annotation 5 ALA A  70
ILE A  63
ILE A 117
ILE A  31
VAL A  18
None
1.12A 4nptA-5cwbA:
undetectable
4nptA-5cwbA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL


(Homo sapiens)
PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3)
5 ILE A 227
GLY A 226
ILE A 201
ILE A 259
VAL A 221
None
EDO  A1606 ( 4.1A)
None
None
None
1.04A 4nptA-5dotA:
undetectable
4nptA-5dotA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6k POLYKETIDE SYNTHASE
PKSL


(Bacillus
subtilis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ALA A 405
ILE A 258
GLY A 260
ILE A 287
VAL A 357
None
1.13A 4nptA-5e6kA:
undetectable
4nptA-5e6kA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL


(Bacillus
subtilis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ALA A 405
ILE A 258
GLY A 260
ILE A 287
VAL A 357
None
1.13A 4nptA-5enyA:
undetectable
4nptA-5enyA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqv BIFUNCTIONAL
2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
PERIPLASMIC
PRECURSOR PROTEIN


(Yersinia pestis)
PF00149
(Metallophos)
5 ALA A 260
ILE A 182
GLY A 183
ILE A 185
VAL A 306
None
0.98A 4nptA-5eqvA:
undetectable
4nptA-5eqvA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxn THERMOLYSIN

(Bacillus
thermoproteolyticus)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
5 ILE A  39
ILE A  20
THR A  80
ILE A 137
VAL A 140
None
1.15A 4nptA-5fxnA:
undetectable
4nptA-5fxnA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hd2 PARASPORAL CRYSTAL
PROTEIN


(Bacillus
thuringiensis)
PF03318
(ETX_MTX2)
5 ASN A 296
GLY A 289
THR A 261
ILE A 294
VAL A 297
None
1.09A 4nptA-5hd2A:
undetectable
4nptA-5hd2A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN


(Trichodesmium
erythraeum)
no annotation 5 ALA A 166
ILE A 105
GLY A 106
ILE A 112
VAL A 157
None
1.11A 4nptA-5jvbA:
undetectable
4nptA-5jvbA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jx5 GLUCANASE

(Orpinomyces sp.
Y102)
PF01341
(Glyco_hydro_6)
5 ASN A 342
ALA A 301
ILE A 250
GLY A 251
THR A 325
None
None
EDO  A 507 (-3.7A)
EDO  A 507 (-4.2A)
None
1.12A 4nptA-5jx5A:
undetectable
4nptA-5jx5A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kpg PAVINE
N-METHYLTRANSFERASE


(Thalictrum
flavum)
PF02353
(CMAS)
5 ALA A 200
ILE A 157
GLY A 156
ILE A 221
VAL A 217
None
1.15A 4nptA-5kpgA:
undetectable
4nptA-5kpgA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpo MOLYBDOPTERIN
SYNTHASE CATALYTIC
SUBUNIT


(Homo sapiens)
PF02391
(MoaE)
5 ALA C 120
ILE C 110
ILE C 155
ILE C  71
VAL C  63
None
0.96A 4nptA-5mpoC:
undetectable
4nptA-5mpoC:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens)
PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind)
5 ILE A 620
GLY A 694
ILE A 687
ILE A 570
VAL A 568
None
1.13A 4nptA-5te1A:
undetectable
4nptA-5te1A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydg MULTIPLE ORGANELLAR
RNA EDITING FACTOR
2, CHLOROPLASTIC


(Arabidopsis
thaliana)
no annotation 5 ALA A 122
ILE A  89
GLY A 138
THR A 145
VAL A 116
None
1.16A 4nptA-5ydgA:
undetectable
4nptA-5ydgA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL


(Homo sapiens)
no annotation 5 ALA A 244
GLY A 250
ILE A 256
ILE A 137
VAL A  89
None
1.11A 4nptA-5zqzA:
undetectable
4nptA-5zqzA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
no annotation 5 ALA A 160
ILE A 123
ILE A 278
THR A 210
ILE A 147
None
1.14A 4nptA-6ao5A:
undetectable
4nptA-6ao5A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1


(Bos taurus)
no annotation 5 GLY A1323
ILE A1483
THR A1479
ILE A1449
VAL A1292
None
1.04A 4nptA-6bhuA:
undetectable
4nptA-6bhuA:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D


(Pyrococcus
furiosus)
no annotation 5 ALA H 264
GLY H 258
ILE H 129
THR H 347
ILE H 344
None
1.09A 4nptA-6cfwH:
undetectable
4nptA-6cfwH:
21.57