SIMILAR PATTERNS OF AMINO ACIDS FOR 4NKX_D_STRD601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elk TARGET OF MYB1

(Homo sapiens) 		PF00790
(VHS) 		4 ILE A 140
ARG A 145
ASP A 126
VAL A  89
 None
 1.10A 4nkxD-1elkA:
undetectable		 4nkxD-1elkA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnz GSI-B4 ISOLECTIN

(Griffonia
simplicifolia) 		PF00139
(Lectin_legB) 		4 ILE A 152
ARG A  51
GLU A 128
VAL A 155
 None
 1.27A 4nkxD-1gnzA:
undetectable		 4nkxD-1gnzA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jc2 TROPONIN C, SKELETAL
MUSCLE

(Gallus gallus) 		PF13499
(EF-hand_7) 		4 ILE A 115
ASP A 140
GLU A 135
VAL A 129
 None
 1.18A 4nkxD-1jc2A:
undetectable		 4nkxD-1jc2A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		4 ILE A 103
ARG A 224
ASP A 456
VAL A 450
 None
 1.16A 4nkxD-1l1lA:
0.0		 4nkxD-1l1lA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n3p LECTIN PAL

(Pterocarpus
angolensis) 		PF00139
(Lectin_legB) 		4 ILE A 154
ARG A  49
GLU A 128
VAL A 157
 None
None
MN  A 271 (-2.8A)
None
 1.27A 4nkxD-1n3pA:
undetectable		 4nkxD-1n3pA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		4 ILE A 212
ARG A 262
ASP A 207
VAL A 160
 None
SO4  A2711 (-3.1A)
SO4  A2711 (-3.7A)
None
 1.27A 4nkxD-1nhcA:
0.0		 4nkxD-1nhcA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)

(Pseudomonas sp.
CF600) 		PF00682
(HMGL-like)
PF01118
(Semialdhyde_dh)
PF07836
(DmpG_comm)
PF09290
(AcetDehyd-dimer) 		4 ILE A 329
ARG A  24
GLU A 326
VAL B 156
 None
SO4  A3513 (-3.7A)
None
None
 1.27A 4nkxD-1nvmA:
0.0		 4nkxD-1nvmA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK

(Escherichia
coli) 		PF02615
(Ldh_2) 		4 ILE A 319
ARG A 316
GLU A  38
VAL A  41
 None
 1.13A 4nkxD-1nxuA:
0.0		 4nkxD-1nxuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ral 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		4 ILE A  42
ARG A   7
ASP A 112
VAL A  61
 None
 1.08A 4nkxD-1ralA:
0.0		 4nkxD-1ralA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA

(Archaeoglobus
fulgidus) 		PF01008
(IF-2B) 		4 ILE A 212
ARG A 182
ASP A 227
VAL A 250
 None
 1.09A 4nkxD-1t5oA:
undetectable		 4nkxD-1t5oA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Trypanosoma
cruzi) 		PF00160
(Pro_isomerase) 		4 ILE A  64
ASP A 138
GLU A 144
VAL A  96
 None
 1.23A 4nkxD-1xq7A:
undetectable		 4nkxD-1xq7A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yif BETA-1,4-XYLOSIDASE

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43) 		4 ILE A 232
ARG A 216
ASP A 298
VAL A 304
 None
 1.23A 4nkxD-1yifA:
undetectable		 4nkxD-1yifA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys2 LIPASE

(Burkholderia
cepacia) 		PF00561
(Abhydrolase_1) 		4 ILE X 290
ARG X 297
GLU X 289
VAL X  84
 None
 1.24A 4nkxD-1ys2X:
undetectable		 4nkxD-1ys2X:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima) 		PF03537
(Glyco_hydro_114) 		4 ILE A 158
ARG A 172
ASP A 209
VAL A 219
 None
 0.90A 4nkxD-2aamA:
undetectable		 4nkxD-2aamA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbh DIVALENT CATION
TRANSPORT-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01544
(CorA) 		4 ILE A  67
ASP A 145
GLU A 141
VAL A 109
 None
 1.06A 4nkxD-2bbhA:
undetectable		 4nkxD-2bbhA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bcc UBIQUINOL CYTOCHROME
C OXIDOREDUCTASE

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ILE A 134
ASP A 142
GLU A 137
VAL A 167
 None
 1.11A 4nkxD-2bccA:
undetectable		 4nkxD-2bccA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvt BETA-1,4-MANNANASE

(Cellulomonas
fimi) 		PF02156
(Glyco_hydro_26) 		4 ILE A  32
ARG A 315
ASP A  25
VAL A  66
 None
 1.13A 4nkxD-2bvtA:
undetectable		 4nkxD-2bvtA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3n GLUTATHIONE
S-TRANSFERASE THETA
1

(Homo sapiens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ILE A 171
ARG A 197
GLU A 199
VAL A 178
 None
 1.17A 4nkxD-2c3nA:
undetectable		 4nkxD-2c3nA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cai GLUTATHIONE
S-TRANSFERASE 28 KDA

(Schistosoma
haematobium) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A 127
ASP A 137
GLU A 108
VAL A 166
 None
 1.07A 4nkxD-2caiA:
undetectable		 4nkxD-2caiA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT

(Bacillus sp.
RAPc8) 		PF02211
(NHase_beta)
PF02979
(NHase_alpha) 		4 ILE A  47
ARG B 113
GLU A  33
VAL B  80
 None
 1.25A 4nkxD-2dppA:
undetectable		 4nkxD-2dppA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 ILE A 194
ARG A 512
ASP A  88
VAL A 106
 None
 1.08A 4nkxD-2i1jA:
undetectable		 4nkxD-2i1jA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7h NITROREDUCTASE-LIKE
FAMILY PROTEIN

(Bacillus cereus) 		PF00881
(Nitroreductase) 		4 ILE A 162
ARG A 127
ASP A  36
VAL A  95
 None
 0.97A 4nkxD-2i7hA:
undetectable		 4nkxD-2i7hA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Porphyromonas
gingivalis) 		PF04095
(NAPRTase) 		4 ILE A 347
ARG A  39
ASP A 100
VAL A  50
 None
 1.26A 4nkxD-2im5A:
undetectable		 4nkxD-2im5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHL

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox) 		4 ILE C 286
ARG C 320
ASP C 223
GLU C 290
 None
 1.27A 4nkxD-2inpC:
undetectable		 4nkxD-2inpC:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is7 ALDOSE REDUCTASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 ILE A  35
ARG A   3
ASP A 105
VAL A  54
 None
 1.10A 4nkxD-2is7A:
undetectable		 4nkxD-2is7A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kdi UBIQUITIN, VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN 27 FUSION
PROTEIN

(Saccharomyces
cerevisiae) 		PF00240
(ubiquitin)
PF02809
(UIM) 		4 ILE A  39
ARG A  81
ASP A  61
VAL A  26
 None
 1.17A 4nkxD-2kdiA:
undetectable		 4nkxD-2kdiA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt8 COBALAMIN
ADENOSYLTRANSFERASE

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 ILE A 113
ARG A 132
ASP A 160
VAL A 106
 None
 1.09A 4nkxD-2nt8A:
undetectable		 4nkxD-2nt8A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE

(Vibrio cholerae) 		PF00571
(CBS) 		4 ILE A  67
ARG A  53
ASP A 142
VAL A 130
 None
PO4  A   6 ( 3.1A)
PO4  A   6 ( 2.6A)
None
 0.97A 4nkxD-2o16A:
undetectable		 4nkxD-2o16A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE

(Macaca
fascicularis) 		PF01408
(GFO_IDH_MocA) 		4 ILE X1317
ASP X1332
GLU X1320
VAL X1199
 None
PO4  X1338 ( 4.6A)
None
None
 1.18A 4nkxD-2o4uX:
undetectable		 4nkxD-2o4uX:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2od4 HYPOTHETICAL PROTEIN

(uncultured
marine organism) 		no annotation 4 ILE A  75
ARG A  83
GLU A  78
VAL A  33
 None
CL  A 102 (-3.2A)
None
None
 1.13A 4nkxD-2od4A:
undetectable		 4nkxD-2od4A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyr UPF0341 PROTEIN YHIQ

(Shigella
flexneri) 		PF04445
(SAM_MT) 		4 ILE A  55
ARG A 188
ASP A  48
VAL A  36
 None
 1.24A 4nkxD-2oyrA:
undetectable		 4nkxD-2oyrA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pe6 SMALL
UBIQUITIN-RELATED
MODIFIER 1

(Homo sapiens) 		PF11976
(Rad60-SLD) 		4 ILE B  88
ARG B  70
ASP B  73
VAL B  38
 None
 1.04A 4nkxD-2pe6B:
undetectable		 4nkxD-2pe6B:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE

(Azospirillum
brasilense) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 376
ARG A 214
ASP A 245
VAL A 367
 None
PPY  A5003 (-3.3A)
None
None
 1.15A 4nkxD-2q5oA:
undetectable		 4nkxD-2q5oA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A1034
ARG A 429
ASP A 471
VAL A1006
 None
 0.85A 4nkxD-2qf7A:
undetectable		 4nkxD-2qf7A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9q ROUNDABOUT HOMOLOG 1

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 ILE A  78
ASP A 141
GLU A 164
VAL A 246
 None
 1.26A 4nkxD-2v9qA:
undetectable		 4nkxD-2v9qA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wm4 PUTATIVE CYTOCHROME
P450 124

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 ILE A 175
ASP A 394
GLU A 388
VAL A 134
 None
None
HEM  A 450 ( 4.2A)
None
 1.24A 4nkxD-2wm4A:
29.7		 4nkxD-2wm4A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymv ACG NITROREDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 4 ILE A 285
ASP A 153
GLU A 162
VAL A 213
 None
 1.22A 4nkxD-2ymvA:
undetectable		 4nkxD-2ymvA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zet MELANOPHILIN
RAS-RELATED PROTEIN
RAB-27B

(Mus musculus) 		PF00071
(Ras)
PF02318
(FYVE_2) 		4 ILE C 115
ASP A 127
GLU A 186
VAL A  68
 None
 1.27A 4nkxD-2zetC:
undetectable		 4nkxD-2zetC:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		no annotation 4 ILE C 154
ASP C 163
GLU C 157
VAL C 188
 None
None
ZN  C   1 (-1.9A)
None
 1.03A 4nkxD-3amjC:
undetectable		 4nkxD-3amjC:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE

(Aquifex
aeolicus) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 ILE A 129
ASP A 147
GLU A 142
VAL A 104
 None
 0.83A 4nkxD-3efsA:
undetectable		 4nkxD-3efsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaj COBALAMIN
ADENOSYLTRANSFERASE
PDUO-LIKE PROTEIN

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 ILE A 113
ARG A 132
ASP A 160
VAL A 106
 None
MG  A 183 ( 4.6A)
MG  A 183 ( 4.5A)
None
 0.91A 4nkxD-3gajA:
undetectable		 4nkxD-3gajA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Nocardioides
aromaticivorans) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 ILE A 366
ASP A 337
GLU A 182
VAL A 268
 None
FE2  A 501 (-1.9A)
None
None
 1.20A 4nkxD-3gcfA:
undetectable		 4nkxD-3gcfA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 ILE A 128
ARG A 145
ASP A 119
VAL A 136
 None
 1.23A 4nkxD-3gq9A:
undetectable		 4nkxD-3gq9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrr AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF14765
(PS-DH) 		4 ILE A1471
ARG A1485
ASP A1509
VAL A1607
 None
 0.98A 4nkxD-3hrrA:
undetectable		 4nkxD-3hrrA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig0 DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 ILE A 513
ARG A 553
ASP A 645
VAL A 496
 ILE  A 513 ( 0.3A)
ARG  A 553 ( 0.6A)
ASP  A 645 ( 0.6A)
VAL  A 496 ( 0.6A)
 1.16A 4nkxD-3ig0A:
undetectable		 4nkxD-3ig0A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig0 DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 ILE A 513
ARG A 553
ASP A 645
VAL A 502
 ILE  A 513 ( 0.3A)
ARG  A 553 ( 0.6A)
ASP  A 645 ( 0.6A)
VAL  A 502 ( 0.6A)
 1.24A 4nkxD-3ig0A:
undetectable		 4nkxD-3ig0A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3itw PROTEIN TIOX

(Micromonospora
sp. ML1) 		PF00903
(Glyoxalase) 		4 ILE A  70
ASP A 108
GLU A 115
VAL A  73
 None
 0.99A 4nkxD-3itwA:
undetectable		 4nkxD-3itwA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS

(Escherichia
coli) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 ILE A 503
ASP A 511
GLU A 505
VAL A 465
 None
 0.92A 4nkxD-3k0sA:
undetectable		 4nkxD-3k0sA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldf PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.776

(Streptococcus
mutans) 		PF10672
(Methyltrans_SAM) 		4 ILE A 153
ASP A 113
GLU A 151
VAL A 128
 None
 1.21A 4nkxD-3ldfA:
undetectable		 4nkxD-3ldfA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
PROTEIN DOM34

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 ILE A 451
ARG B 171
ASP A 410
VAL A 430
 None
 1.21A 4nkxD-3mcaA:
undetectable		 4nkxD-3mcaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ILE A 382
ARG A 386
GLU A 353
VAL A 360
 None
 1.19A 4nkxD-3nvlA:
undetectable		 4nkxD-3nvlA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A 331
ARG A 226
GLU A 314
VAL A 321
 None
 1.20A 4nkxD-3o04A:
undetectable		 4nkxD-3o04A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia pestis) 		PF04095
(NAPRTase) 		4 ILE A 129
ARG A 136
ASP A  52
VAL A  98
 None
 1.22A 4nkxD-3os4A:
undetectable		 4nkxD-3os4A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyz MALATE SYNTHASE

(Haloferax
volcanii) 		PF03328
(HpcH_HpaI) 		4 ILE A 121
ARG A  89
ASP A 192
VAL A  47
 None
None
MG  A 500 ( 2.9A)
None
 1.09A 4nkxD-3oyzA:
undetectable		 4nkxD-3oyzA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qiv SHORT-CHAIN
DEHYDROGENASE OR
3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 ILE A  57
ASP A  74
GLU A  79
VAL A   7
 None
 1.17A 4nkxD-3qivA:
undetectable		 4nkxD-3qivA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quf EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF13416
(SBP_bac_8) 		4 ILE A 247
ARG A 237
ASP A 170
VAL A 270
 None
 1.04A 4nkxD-3qufA:
undetectable		 4nkxD-3qufA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3riq TAILSPIKE PROTEIN

(Salmonella
virus 9NA) 		PF09251
(PhageP22-tail) 		4 ILE A 453
ASP A 497
GLU A 475
VAL A 491
 None
 1.11A 4nkxD-3riqA:
undetectable		 4nkxD-3riqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		4 ILE A 370
ARG A 343
GLU A 366
VAL A 323
 None
 0.98A 4nkxD-3sfzA:
undetectable		 4nkxD-3sfzA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B

(Bacillus
subtilis) 		PF12705
(PDDEXK_1) 		4 ILE B  19
ARG B 283
GLU B  50
VAL B  65
 None
 0.98A 4nkxD-3u44B:
undetectable		 4nkxD-3u44B:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 155
ASP A 511
GLU A 376
VAL A 400
 None
 1.26A 4nkxD-3v98A:
undetectable		 4nkxD-3v98A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8) 		4 ILE A 377
ASP A 522
GLU A 459
VAL A 411
 None
 1.24A 4nkxD-4blaA:
undetectable		 4nkxD-4blaA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		4 ILE A 660
ASP A 694
GLU A 701
VAL A 667
 None
 1.16A 4nkxD-4cekA:
undetectable		 4nkxD-4cekA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 ILE A  70
ASP A 128
GLU A 136
VAL A  39
 None
 1.07A 4nkxD-4cgyA:
undetectable		 4nkxD-4cgyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 ILE A  59
ASP A  76
GLU A  81
VAL A   8
 None
 1.17A 4nkxD-4da9A:
undetectable		 4nkxD-4da9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffu OXIDASE

(Sinorhizobium
meliloti) 		PF01575
(MaoC_dehydratas) 		4 ARG A 120
ASP A  86
GLU A 123
VAL A  69
 None
 1.25A 4nkxD-4ffuA:
undetectable		 4nkxD-4ffuA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

([Haemophilus]
ducreyi) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		4 ILE A 412
ASP A 359
GLU A 352
VAL A 395
 None
 1.17A 4nkxD-4k3cA:
undetectable		 4nkxD-4k3cA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN

(Acidaminococcus
fermentans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 292
ASP A  81
GLU A 255
VAL A 299
 None
 1.23A 4nkxD-4l1fA:
undetectable		 4nkxD-4l1fA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4i RYANODINE RECEPTOR 2

(Mus musculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 ILE A 419
ARG A 414
ASP A 458
VAL A 498
 None
GOL  A 601 (-3.3A)
GOL  A 601 (-4.5A)
None
 1.21A 4nkxD-4l4iA:
undetectable		 4nkxD-4l4iA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lza ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermoanaerobacter
pseudethanolicus) 		PF00156
(Pribosyltran) 		4 ILE A 128
ARG A 157
ASP A 164
VAL A 135
 None
CL  A 201 ( 4.6A)
None
None
 1.19A 4nkxD-4lzaA:
undetectable		 4nkxD-4lzaA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtk VGRG1

(Pseudomonas
aeruginosa) 		PF05954
(Phage_GPD) 		4 ILE A 108
ARG A 157
ASP A 439
VAL A 390
 None
 1.26A 4nkxD-4mtkA:
undetectable		 4nkxD-4mtkA:
20.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		5 ILE A 206
ARG A 239
ASP A 298
GLU A 305
VAL A 366
 3QZ  A 601 ( 4.6A)
3QZ  A 601 ( 4.4A)
3QZ  A 601 (-3.5A)
3QZ  A 601 ( 4.9A)
HEM  A 600 ( 3.4A)
 0.29A 4nkxD-4nkyA:
60.4		 4nkxD-4nkyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsp ENDONUCLEASE V

(Homo sapiens) 		PF04493
(Endonuclease_5) 		4 ILE A 209
ARG A 222
ASP A  32
VAL A 130
 None
 1.24A 4nkxD-4nspA:
undetectable		 4nkxD-4nspA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv1 FORMYLTRANSFERASE

(Francisella
tularensis) 		no annotation 4 ILE C 224
ASP C 198
GLU C 194
VAL C 233
 None
 1.12A 4nkxD-4nv1C:
undetectable		 4nkxD-4nv1C:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		4 ILE A 368
ARG A 255
ASP A 233
VAL A 371
 None
 1.17A 4nkxD-4ohtA:
undetectable		 4nkxD-4ohtA:
23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		4 ARG A 252
ASP A 309
GLU A 316
VAL A 377
 None
AER  A 601 ( 4.1A)
None
HEM  A 600 (-4.6A)
 0.77A 4nkxD-4r1zA:
51.1		 4nkxD-4r1zA:
46.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9g MBP1

(Caldanaerobius
polysaccharolyticus) 		PF13416
(SBP_bac_8) 		4 ILE A 344
ASP A 359
GLU A 271
VAL A 368
 None
 1.27A 4nkxD-4r9gA:
undetectable		 4nkxD-4r9gA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A 293
ARG A 352
ASP A 399
VAL A   7
 None
 1.22A 4nkxD-4rcnA:
undetectable		 4nkxD-4rcnA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zve DIGUANYLATE CYCLASE
DOSC

(Escherichia
coli) 		PF00990
(GGDEF) 		4 ILE A 420
ARG A 450
ASP A 376
VAL A 370
 None
CIT  A 501 ( 3.2A)
CIT  A 501 (-3.6A)
None
 1.27A 4nkxD-4zveA:
undetectable		 4nkxD-4zveA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 ILE A 665
ARG A 782
ASP A 758
VAL A 695
 None
 1.27A 4nkxD-5eawA:
undetectable		 4nkxD-5eawA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		4 ILE A 672
ARG A 580
ASP A 609
VAL A 653
 C2E  A 919 (-3.5A)
C2E  A 920 ( 3.7A)
C2E  A 919 (-3.2A)
None
 0.88A 4nkxD-5ej1A:
undetectable		 4nkxD-5ej1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ILE A 622
ARG A 630
ASP A 540
VAL A 516
 None
 1.14A 4nkxD-5favA:
undetectable		 4nkxD-5favA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irp ALANINE RACEMASE 2

(Bacillus
subtilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ILE A 284
ARG A 264
GLU A 282
VAL A 312
 None
None
MG  A 414 (-3.4A)
None
 1.07A 4nkxD-5irpA:
undetectable		 4nkxD-5irpA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128
SCAFFOLDIN C

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin)
no annotation 		4 ILE A 102
ARG B 908
ASP A  77
VAL A  24
 None
 1.20A 4nkxD-5lxvA:
undetectable		 4nkxD-5lxvA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 4 ILE A 465
ARG A 406
ASP A 576
VAL A 535
 None
 0.79A 4nkxD-5m6gA:
undetectable		 4nkxD-5m6gA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmi CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL

(Bos taurus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ILE A 134
ASP A 142
GLU A 137
VAL A 167
 None
 1.19A 4nkxD-5nmiA:
undetectable		 4nkxD-5nmiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nno ALDEHYDE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00171
(Aldedh) 		4 ILE A  61
ASP A  70
GLU A  76
VAL A  50
 None
 1.13A 4nkxD-5nnoA:
undetectable		 4nkxD-5nnoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D

(Homo sapiens) 		no annotation 4 ILE 0 443
ARG 0 412
ASP 0 458
VAL 0 452
 None
 1.20A 4nkxD-5oa30:
undetectable		 4nkxD-5oa30:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olc GALACTONATE
DEHYDRATASE

(Zobellia
galactanivorans) 		no annotation 4 ILE A  33
ASP A 102
GLU A  47
VAL A 363
 None
 1.17A 4nkxD-5olcA:
undetectable		 4nkxD-5olcA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thw DEACYLASE

(Burkholderia
multivorans) 		PF01546
(Peptidase_M20) 		4 ARG A  55
ASP A  98
GLU A 179
VAL A 171
 None
 1.22A 4nkxD-5thwA:
undetectable		 4nkxD-5thwA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu0 LMO2125 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		4 ILE A 141
ASP A 335
GLU A 339
VAL A 361
 None
 1.20A 4nkxD-5tu0A:
undetectable		 4nkxD-5tu0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjw RHIZOBIALES-LIKE
PHOSPHATASE 2

(Arabidopsis
thaliana) 		no annotation 4 ILE A 210
ASP A 195
GLU A 192
VAL A  75
 None
 1.22A 4nkxD-5vjwA:
undetectable		 4nkxD-5vjwA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 4 ILE B  77
ARG B  98
ASP B 121
VAL B 104
 None
 1.26A 4nkxD-5xwuB:
undetectable		 4nkxD-5xwuB:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yll BETA-1,4-MANNANASE

(Amphibacillus
xylanus) 		no annotation 4 ILE B 120
ASP B 152
GLU B 160
VAL B 140
 None
 1.25A 4nkxD-5yllB:
undetectable		 4nkxD-5yllB:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cty DIHYDROOROTASE

(Yersinia pestis) 		no annotation 4 ILE A 150
ARG A 156
ASP A 183
GLU A 142
 None
 1.23A 4nkxD-6ctyA:
undetectable		 4nkxD-6ctyA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft

() 		no annotation 4 ILE A 329
ARG B 270
GLU A 166
VAL A 227
 None
 1.03A 4nkxD-6dftA:
undetectable		 4nkxD-6dftA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eyy ACRIIA6

(Streptococcus
phage 73) 		no annotation 4 ILE A 175
ARG A 168
ASP A 113
GLU A 176
 None
 1.21A 4nkxD-6eyyA:
undetectable		 4nkxD-6eyyA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft5 -

(-) 		no annotation 4 ILE A  77
ARG A  81
GLU A  49
VAL A  21
 None
 1.21A 4nkxD-6ft5A:
undetectable		 4nkxD-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
13
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
5

(Mus musculus) 		no annotation 4 ILE e  40
ARG Z 114
ASP e  61
GLU e  36
 None
 1.08A 4nkxD-6g72e:
undetectable		 4nkxD-6g72e:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT 4

(Mus musculus) 		no annotation 4 ILE m 115
ARG m 110
ASP m 107
GLU m 112
 None
 1.26A 4nkxD-6g72m:
undetectable		 4nkxD-6g72m:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ged PRGB

(Enterococcus
faecalis) 		no annotation 4 ARG A 406
ASP A 411
GLU A 455
VAL A 474
 None
None
NA  A 601 (-2.9A)
None
 1.26A 4nkxD-6gedA:
undetectable		 4nkxD-6gedA:
10.66