SIMILAR PATTERNS OF AMINO ACIDS FOR 4NKX_C_STRC601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elk TARGET OF MYB1

(Homo sapiens) 		PF00790
(VHS) 		4 ILE A 140
ARG A 145
ASP A 126
VAL A  89
 None
 1.09A 4nkxC-1elkA:
undetectable		 4nkxC-1elkA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7g 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Escherichia
coli) 		PF02348
(CTP_transf_3) 		4 ILE A 212
ARG A 179
ASP A 117
VAL A 144
 None
 1.25A 4nkxC-1h7gA:
0.0		 4nkxC-1h7gA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jc2 TROPONIN C, SKELETAL
MUSCLE

(Gallus gallus) 		PF13499
(EF-hand_7) 		4 ILE A 115
ASP A 140
GLU A 135
VAL A 129
 None
 1.18A 4nkxC-1jc2A:
undetectable		 4nkxC-1jc2A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		4 ILE A 103
ARG A 224
ASP A 456
VAL A 450
 None
 1.19A 4nkxC-1l1lA:
0.0		 4nkxC-1l1lA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		4 ILE A 212
ARG A 262
ASP A 207
VAL A 160
 None
SO4  A2711 (-3.1A)
SO4  A2711 (-3.7A)
None
 1.24A 4nkxC-1nhcA:
0.0		 4nkxC-1nhcA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK

(Escherichia
coli) 		PF02615
(Ldh_2) 		4 ILE A 319
ARG A 316
GLU A  38
VAL A  41
 None
 1.11A 4nkxC-1nxuA:
0.0		 4nkxC-1nxuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ral 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		4 ILE A  42
ARG A   7
ASP A 112
VAL A  61
 None
 1.06A 4nkxC-1ralA:
0.0		 4nkxC-1ralA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy6 OKT3 FAB HEAVY CHAIN
T-CELL SURFACE
GLYCOPROTEIN CD3
GAMMA/EPSILON CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF16680
(Ig_4)
PF16681
(Ig_5) 		4 ILE A 151
ARG H  31
ASP H 102
VAL A 182
 None
 1.22A 4nkxC-1sy6A:
undetectable		 4nkxC-1sy6A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA

(Archaeoglobus
fulgidus) 		PF01008
(IF-2B) 		4 ILE A 212
ARG A 182
ASP A 227
VAL A 250
 None
 1.08A 4nkxC-1t5oA:
undetectable		 4nkxC-1t5oA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		4 ILE A 410
ARG A 426
ASP A 457
GLU A 467
 None
 1.19A 4nkxC-1v02A:
0.0		 4nkxC-1v02A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xov PLY PROTEIN

(Listeria virus
PSA) 		PF01520
(Amidase_3) 		4 ILE A  49
ASP A  36
GLU A  28
VAL A  78
 None
 1.15A 4nkxC-1xovA:
undetectable		 4nkxC-1xovA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykd ADENYLATE CYCLASE

(Anabaena sp.) 		PF01590
(GAF) 		4 ILE A 139
ASP A 136
GLU A 142
VAL A 194
 CMP  A 501 (-4.2A)
None
None
None
 1.16A 4nkxC-1ykdA:
undetectable		 4nkxC-1ykdA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys2 LIPASE

(Burkholderia
cepacia) 		PF00561
(Abhydrolase_1) 		4 ILE X 290
ARG X 297
GLU X 289
VAL X  84
 None
 1.22A 4nkxC-1ys2X:
undetectable		 4nkxC-1ys2X:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima) 		PF03537
(Glyco_hydro_114) 		4 ILE A 158
ARG A 172
ASP A 209
VAL A 219
 None
 0.89A 4nkxC-2aamA:
undetectable		 4nkxC-2aamA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbh DIVALENT CATION
TRANSPORT-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01544
(CorA) 		4 ILE A  67
ASP A 145
GLU A 141
VAL A 109
 None
 1.06A 4nkxC-2bbhA:
undetectable		 4nkxC-2bbhA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bcc UBIQUINOL CYTOCHROME
C OXIDOREDUCTASE

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ILE A 134
ASP A 142
GLU A 137
VAL A 167
 None
 1.07A 4nkxC-2bccA:
undetectable		 4nkxC-2bccA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvt BETA-1,4-MANNANASE

(Cellulomonas
fimi) 		PF02156
(Glyco_hydro_26) 		4 ILE A  32
ARG A 315
ASP A  25
VAL A  66
 None
 1.09A 4nkxC-2bvtA:
undetectable		 4nkxC-2bvtA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3n GLUTATHIONE
S-TRANSFERASE THETA
1

(Homo sapiens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ILE A 171
ARG A 197
GLU A 199
VAL A 178
 None
 1.16A 4nkxC-2c3nA:
undetectable		 4nkxC-2c3nA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cai GLUTATHIONE
S-TRANSFERASE 28 KDA

(Schistosoma
haematobium) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A 127
ASP A 137
GLU A 108
VAL A 166
 None
 1.08A 4nkxC-2caiA:
undetectable		 4nkxC-2caiA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT

(Bacillus sp.
RAPc8) 		PF02211
(NHase_beta)
PF02979
(NHase_alpha) 		4 ILE A  47
ARG B 113
GLU A  33
VAL B  80
 None
 1.22A 4nkxC-2dppA:
undetectable		 4nkxC-2dppA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		4 ILE A 372
ARG A 315
ASP A 428
VAL A 504
 None
 1.20A 4nkxC-2e0pA:
undetectable		 4nkxC-2e0pA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 ILE A 194
ARG A 512
ASP A  88
VAL A 106
 None
 1.03A 4nkxC-2i1jA:
undetectable		 4nkxC-2i1jA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7h NITROREDUCTASE-LIKE
FAMILY PROTEIN

(Bacillus cereus) 		PF00881
(Nitroreductase) 		4 ILE A 162
ARG A 127
ASP A  36
VAL A  95
 None
 0.99A 4nkxC-2i7hA:
undetectable		 4nkxC-2i7hA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iiz MELANIN BIOSYNTHESIS
PROTEIN TYRA,
PUTATIVE

(Shewanella
oneidensis) 		PF04261
(Dyp_perox) 		4 ILE A  98
ASP A 101
GLU A 133
VAL A 182
 None
 1.17A 4nkxC-2iizA:
undetectable		 4nkxC-2iizA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is7 ALDOSE REDUCTASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 ILE A  35
ARG A   3
ASP A 105
VAL A  54
 None
 1.08A 4nkxC-2is7A:
undetectable		 4nkxC-2is7A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kdi UBIQUITIN, VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN 27 FUSION
PROTEIN

(Saccharomyces
cerevisiae) 		PF00240
(ubiquitin)
PF02809
(UIM) 		4 ILE A  39
ARG A  81
ASP A  61
VAL A  26
 None
 1.14A 4nkxC-2kdiA:
undetectable		 4nkxC-2kdiA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 ILE A 162
ASP A 169
GLU A 166
VAL A 147
 None
 0.82A 4nkxC-2mbrA:
undetectable		 4nkxC-2mbrA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt8 COBALAMIN
ADENOSYLTRANSFERASE

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 ILE A 113
ARG A 132
ASP A 160
VAL A 106
 None
 1.08A 4nkxC-2nt8A:
undetectable		 4nkxC-2nt8A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE

(Vibrio cholerae) 		PF00571
(CBS) 		4 ILE A  67
ARG A  53
ASP A 142
VAL A 130
 None
PO4  A   6 ( 3.1A)
PO4  A   6 ( 2.6A)
None
 0.97A 4nkxC-2o16A:
undetectable		 4nkxC-2o16A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2od4 HYPOTHETICAL PROTEIN

(uncultured
marine organism) 		no annotation 4 ILE A  75
ARG A  83
GLU A  78
VAL A  33
 None
CL  A 102 (-3.2A)
None
None
 1.19A 4nkxC-2od4A:
undetectable		 4nkxC-2od4A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyr UPF0341 PROTEIN YHIQ

(Shigella
flexneri) 		PF04445
(SAM_MT) 		4 ILE A  55
ARG A 188
ASP A  48
VAL A  36
 None
 1.25A 4nkxC-2oyrA:
undetectable		 4nkxC-2oyrA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pe6 SMALL
UBIQUITIN-RELATED
MODIFIER 1

(Homo sapiens) 		PF11976
(Rad60-SLD) 		4 ILE B  88
ARG B  70
ASP B  73
VAL B  38
 None
 1.00A 4nkxC-2pe6B:
undetectable		 4nkxC-2pe6B:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE

(Azospirillum
brasilense) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 376
ARG A 214
ASP A 245
VAL A 367
 None
PPY  A5003 (-3.3A)
None
None
 1.15A 4nkxC-2q5oA:
undetectable		 4nkxC-2q5oA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A1034
ARG A 429
ASP A 471
VAL A1006
 None
 0.84A 4nkxC-2qf7A:
undetectable		 4nkxC-2qf7A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9q ROUNDABOUT HOMOLOG 1

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 ILE A  78
ASP A 141
GLU A 164
VAL A 246
 None
 1.20A 4nkxC-2v9qA:
undetectable		 4nkxC-2v9qA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xva TELLURITE RESISTANCE
PROTEIN TEHB

(Escherichia
coli) 		PF03848
(TehB) 		4 ILE A  74
ASP A  78
GLU A  75
VAL A  68
 None
 1.05A 4nkxC-2xvaA:
undetectable		 4nkxC-2xvaA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymv ACG NITROREDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 4 ILE A 285
ASP A 153
GLU A 162
VAL A 213
 None
 1.21A 4nkxC-2ymvA:
undetectable		 4nkxC-2ymvA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zet MELANOPHILIN
RAS-RELATED PROTEIN
RAB-27B

(Mus musculus) 		PF00071
(Ras)
PF02318
(FYVE_2) 		4 ILE C 115
ASP A 127
GLU A 186
VAL A  68
 None
 1.24A 4nkxC-2zetC:
undetectable		 4nkxC-2zetC:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		no annotation 4 ILE C 154
ASP C 163
GLU C 157
VAL C 188
 None
None
ZN  C   1 (-1.9A)
None
 1.05A 4nkxC-3amjC:
undetectable		 4nkxC-3amjC:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfn KINESIN-LIKE PROTEIN
KIF22

(Homo sapiens) 		PF00225
(Kinesin) 		4 ILE A 205
ARG A 202
GLU A 199
VAL A 196
 None
 0.86A 4nkxC-3bfnA:
undetectable		 4nkxC-3bfnA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE

(Aquifex
aeolicus) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 ILE A 129
ASP A 147
GLU A 142
VAL A 104
 None
 0.83A 4nkxC-3efsA:
undetectable		 4nkxC-3efsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaj COBALAMIN
ADENOSYLTRANSFERASE
PDUO-LIKE PROTEIN

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 ILE A 113
ARG A 132
ASP A 160
VAL A 106
 None
MG  A 183 ( 4.6A)
MG  A 183 ( 4.5A)
None
 0.92A 4nkxC-3gajA:
undetectable		 4nkxC-3gajA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Nocardioides
aromaticivorans) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 ILE A 366
ASP A 337
GLU A 182
VAL A 268
 None
FE2  A 501 (-1.9A)
None
None
 1.19A 4nkxC-3gcfA:
undetectable		 4nkxC-3gcfA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 ILE A 128
ARG A 145
ASP A 119
VAL A 136
 None
 1.24A 4nkxC-3gq9A:
undetectable		 4nkxC-3gq9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ILE A 134
ASP A 142
GLU A 137
VAL A 167
 None
 1.24A 4nkxC-3h1lA:
undetectable		 4nkxC-3h1lA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrr AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF14765
(PS-DH) 		4 ILE A1471
ARG A1485
ASP A1509
VAL A1607
 None
 0.94A 4nkxC-3hrrA:
undetectable		 4nkxC-3hrrA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig0 DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 ILE A 513
ARG A 553
ASP A 645
VAL A 496
 ILE  A 513 ( 0.3A)
ARG  A 553 ( 0.6A)
ASP  A 645 ( 0.6A)
VAL  A 496 ( 0.6A)
 1.17A 4nkxC-3ig0A:
undetectable		 4nkxC-3ig0A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3itw PROTEIN TIOX

(Micromonospora
sp. ML1) 		PF00903
(Glyoxalase) 		4 ILE A  70
ASP A 108
GLU A 115
VAL A  73
 None
 1.00A 4nkxC-3itwA:
undetectable		 4nkxC-3itwA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS

(Escherichia
coli) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 ILE A 503
ASP A 511
GLU A 505
VAL A 465
 None
 0.94A 4nkxC-3k0sA:
undetectable		 4nkxC-3k0sA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldf PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.776

(Streptococcus
mutans) 		PF10672
(Methyltrans_SAM) 		4 ILE A 153
ASP A 113
GLU A 151
VAL A 128
 None
 1.22A 4nkxC-3ldfA:
undetectable		 4nkxC-3ldfA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
PROTEIN DOM34

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 ILE A 451
ARG B 171
ASP A 410
VAL A 430
 None
 1.19A 4nkxC-3mcaA:
undetectable		 4nkxC-3mcaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ILE A 382
ARG A 386
GLU A 353
VAL A 360
 None
 1.21A 4nkxC-3nvlA:
undetectable		 4nkxC-3nvlA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A 331
ARG A 226
GLU A 314
VAL A 321
 None
 1.21A 4nkxC-3o04A:
undetectable		 4nkxC-3o04A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia pestis) 		PF04095
(NAPRTase) 		4 ILE A 129
ARG A 136
ASP A  52
VAL A  98
 None
 1.20A 4nkxC-3os4A:
undetectable		 4nkxC-3os4A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyz MALATE SYNTHASE

(Haloferax
volcanii) 		PF03328
(HpcH_HpaI) 		4 ILE A 121
ARG A  89
ASP A 192
VAL A  47
 None
None
MG  A 500 ( 2.9A)
None
 1.09A 4nkxC-3oyzA:
undetectable		 4nkxC-3oyzA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qiv SHORT-CHAIN
DEHYDROGENASE OR
3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 ILE A  57
ASP A  74
GLU A  79
VAL A   7
 None
 1.15A 4nkxC-3qivA:
undetectable		 4nkxC-3qivA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quf EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF13416
(SBP_bac_8) 		4 ILE A 247
ARG A 237
ASP A 170
VAL A 270
 None
 1.07A 4nkxC-3qufA:
undetectable		 4nkxC-3qufA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3riq TAILSPIKE PROTEIN

(Salmonella
virus 9NA) 		PF09251
(PhageP22-tail) 		4 ILE A 453
ASP A 497
GLU A 475
VAL A 491
 None
 1.10A 4nkxC-3riqA:
undetectable		 4nkxC-3riqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		4 ILE A 370
ARG A 343
GLU A 366
VAL A 323
 None
 1.02A 4nkxC-3sfzA:
undetectable		 4nkxC-3sfzA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 ILE A 412
ASP A 380
GLU A 387
VAL A 659
 None
 1.16A 4nkxC-3snhA:
2.9		 4nkxC-3snhA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		4 ILE A 327
ASP A 357
GLU A 324
VAL A 317
 None
 1.19A 4nkxC-3up4A:
undetectable		 4nkxC-3up4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		4 ILE A 660
ASP A 694
GLU A 701
VAL A 667
 None
 1.11A 4nkxC-4cekA:
undetectable		 4nkxC-4cekA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 ILE A  70
ASP A 128
GLU A 136
VAL A  39
 None
 1.04A 4nkxC-4cgyA:
undetectable		 4nkxC-4cgyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 ARG K 333
ASP K 204
GLU J 364
VAL J 377
 None
 1.19A 4nkxC-4cr4K:
undetectable		 4nkxC-4cr4K:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 ILE A  59
ASP A  76
GLU A  81
VAL A   8
 None
 1.17A 4nkxC-4da9A:
undetectable		 4nkxC-4da9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffu OXIDASE

(Sinorhizobium
meliloti) 		PF01575
(MaoC_dehydratas) 		4 ARG A 120
ASP A  86
GLU A 123
VAL A  69
 None
 1.23A 4nkxC-4ffuA:
undetectable		 4nkxC-4ffuA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

([Haemophilus]
ducreyi) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		4 ILE A 412
ASP A 359
GLU A 352
VAL A 395
 None
 1.14A 4nkxC-4k3cA:
undetectable		 4nkxC-4k3cA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN

(Acidaminococcus
fermentans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 292
ASP A  81
GLU A 255
VAL A 299
 None
 1.24A 4nkxC-4l1fA:
undetectable		 4nkxC-4l1fA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lza ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermoanaerobacter
pseudethanolicus) 		PF00156
(Pribosyltran) 		4 ILE A 128
ARG A 157
ASP A 164
VAL A 135
 None
CL  A 201 ( 4.6A)
None
None
 1.17A 4nkxC-4lzaA:
undetectable		 4nkxC-4lzaA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtk VGRG1

(Pseudomonas
aeruginosa) 		PF05954
(Phage_GPD) 		4 ILE A 108
ARG A 157
ASP A 439
VAL A 390
 None
 1.24A 4nkxC-4mtkA:
undetectable		 4nkxC-4mtkA:
20.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		5 ILE A 206
ARG A 239
ASP A 298
GLU A 305
VAL A 366
 3QZ  A 601 ( 4.6A)
3QZ  A 601 ( 4.4A)
3QZ  A 601 (-3.5A)
3QZ  A 601 ( 4.9A)
HEM  A 600 ( 3.4A)
 0.31A 4nkxC-4nkyA:
60.7		 4nkxC-4nkyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsp ENDONUCLEASE V

(Homo sapiens) 		PF04493
(Endonuclease_5) 		4 ILE A 209
ARG A 222
ASP A  32
VAL A 130
 None
 1.22A 4nkxC-4nspA:
undetectable		 4nkxC-4nspA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv1 FORMYLTRANSFERASE

(Francisella
tularensis) 		no annotation 4 ILE C 224
ASP C 198
GLU C 194
VAL C 233
 None
 1.11A 4nkxC-4nv1C:
undetectable		 4nkxC-4nv1C:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		4 ILE A 368
ARG A 255
ASP A 233
VAL A 371
 None
 1.19A 4nkxC-4ohtA:
undetectable		 4nkxC-4ohtA:
23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		4 ARG A 252
ASP A 309
GLU A 316
VAL A 377
 None
AER  A 601 ( 4.1A)
None
HEM  A 600 (-4.6A)
 0.87A 4nkxC-4r1zA:
51.2		 4nkxC-4r1zA:
46.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A 293
ARG A 352
ASP A 399
VAL A   7
 None
 1.24A 4nkxC-4rcnA:
undetectable		 4nkxC-4rcnA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3w 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 ILE A 117
ASP A  91
GLU A  87
VAL A 202
 EDO  A 504 (-3.6A)
None
EDO  A 504 (-4.5A)
None
 1.25A 4nkxC-4u3wA:
undetectable		 4nkxC-4u3wA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A 106
ARG A 148
ASP A 128
VAL A  93
 None
 1.25A 4nkxC-5b83A:
undetectable		 4nkxC-5b83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		4 ILE A 672
ARG A 580
ASP A 609
VAL A 653
 C2E  A 919 (-3.5A)
C2E  A 920 ( 3.7A)
C2E  A 919 (-3.2A)
None
 0.91A 4nkxC-5ej1A:
undetectable		 4nkxC-5ej1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esy SAL1 PHOSPHATASE

(Arabidopsis
thaliana) 		PF00459
(Inositol_P) 		4 ILE A 325
ASP A 320
GLU A 284
VAL A 290
 None
 1.18A 4nkxC-5esyA:
undetectable		 4nkxC-5esyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ILE A 622
ARG A 630
ASP A 540
VAL A 516
 None
 1.13A 4nkxC-5favA:
undetectable		 4nkxC-5favA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE

(Medicago
truncatula) 		PF00795
(CN_hydrolase) 		4 ILE A 118
ASP A  72
GLU A  96
VAL A  92
 None
 1.21A 4nkxC-5h8kA:
undetectable		 4nkxC-5h8kA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irp ALANINE RACEMASE 2

(Bacillus
subtilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ILE A 284
ARG A 264
GLU A 282
VAL A 312
 None
None
MG  A 414 (-3.4A)
None
 1.07A 4nkxC-5irpA:
undetectable		 4nkxC-5irpA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyu TWO-COMPONENT SENSOR
HISTIDINE KINASE

(Thermosynechococcus
elongatus) 		no annotation 4 ILE A 690
ASP A 669
GLU A 663
VAL A 619
 None
 1.22A 4nkxC-5jyuA:
undetectable		 4nkxC-5jyuA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128
SCAFFOLDIN C

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin)
no annotation 		4 ILE A 102
ARG B 908
ASP A  77
VAL A  24
 None
 1.22A 4nkxC-5lxvA:
undetectable		 4nkxC-5lxvA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 4 ILE A 465
ARG A 406
ASP A 576
VAL A 535
 None
 0.83A 4nkxC-5m6gA:
undetectable		 4nkxC-5m6gA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmi CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL

(Bos taurus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ILE A 134
ASP A 142
GLU A 137
VAL A 167
 None
 1.16A 4nkxC-5nmiA:
undetectable		 4nkxC-5nmiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nno ALDEHYDE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00171
(Aldedh) 		4 ILE A  61
ASP A  70
GLU A  76
VAL A  50
 None
 1.16A 4nkxC-5nnoA:
undetectable		 4nkxC-5nnoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D

(Homo sapiens) 		no annotation 4 ILE 0 443
ARG 0 412
ASP 0 458
VAL 0 452
 None
 1.20A 4nkxC-5oa30:
undetectable		 4nkxC-5oa30:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olc GALACTONATE
DEHYDRATASE

(Zobellia
galactanivorans) 		no annotation 4 ILE A  33
ASP A 102
GLU A  47
VAL A 363
 None
 1.19A 4nkxC-5olcA:
undetectable		 4nkxC-5olcA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu0 LMO2125 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		4 ILE A 141
ASP A 335
GLU A 339
VAL A 361
 None
 1.21A 4nkxC-5tu0A:
undetectable		 4nkxC-5tu0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjw RHIZOBIALES-LIKE
PHOSPHATASE 2

(Arabidopsis
thaliana) 		no annotation 4 ILE A 210
ASP A 195
GLU A 192
VAL A  75
 None
 1.24A 4nkxC-5vjwA:
undetectable		 4nkxC-5vjwA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Acinetobacter
baumannii) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ARG A 196
ASP A  17
GLU A  68
VAL A  57
 3PG  A 603 (-3.2A)
MN  A 602 ( 2.2A)
None
None
 1.23A 4nkxC-5vpuA:
undetectable		 4nkxC-5vpuA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yll BETA-1,4-MANNANASE

(Amphibacillus
xylanus) 		no annotation 4 ILE B 120
ASP B 152
GLU B 160
VAL B 140
 None
 1.20A 4nkxC-5yllB:
undetectable		 4nkxC-5yllB:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqj BETA-XYLOSIDASE

(Bacillus
pumilus) 		no annotation 4 ILE A 232
ARG A 216
ASP A 298
VAL A 304
 None
 1.24A 4nkxC-5zqjA:
undetectable		 4nkxC-5zqjA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0g PIRIN FAMILY PROTEIN

(Acinetobacter
baumannii) 		no annotation 4 ILE A 193
ASP A 163
GLU A 166
VAL A 190
 None
 1.24A 4nkxC-6d0gA:
undetectable		 4nkxC-6d0gA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft

() 		no annotation 4 ILE A 329
ARG B 270
GLU A 166
VAL A 227
 None
 1.00A 4nkxC-6dftA:
undetectable		 4nkxC-6dftA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eyy ACRIIA6

(Streptococcus
phage 73) 		no annotation 4 ILE A 175
ARG A 168
ASP A 113
GLU A 176
 None
 1.24A 4nkxC-6eyyA:
undetectable		 4nkxC-6eyyA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft5 -

(-) 		no annotation 4 ILE A  77
ARG A  81
GLU A  49
VAL A  21
 None
 1.19A 4nkxC-6ft5A:
undetectable		 4nkxC-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
13
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
5

(Mus musculus) 		no annotation 4 ILE e  40
ARG Z 114
ASP e  61
GLU e  36
 None
 1.04A 4nkxC-6g72e:
undetectable		 4nkxC-6g72e:
9.87