SIMILAR PATTERNS OF AMINO ACIDS FOR 4NKX_B_STRB601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)

(Escherichia
virus T4) 		PF00303
(Thymidylat_synt) 		4 ILE A  34
LEU A  15
ASP A 171
GLU A  35
 None
 1.05A 4nkxB-1b5dA:
0.0		 4nkxB-1b5dA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 ILE A 387
LEU A 352
ASP A 365
GLU A 385
 None
 1.07A 4nkxB-1e43A:
undetectable		 4nkxB-1e43A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1es6 MATRIX PROTEIN VP40

(Ebola virus sp.) 		PF07447
(VP40) 		4 ILE A  82
LEU A  88
ASP A  45
VAL A 162
 None
 1.01A 4nkxB-1es6A:
undetectable		 4nkxB-1es6A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jct GLUCARATE
DEHYDRATASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		4 ILE A 248
LEU A 252
GLU A 216
VAL A 188
 None
 1.02A 4nkxB-1jctA:
0.0		 4nkxB-1jctA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		4 ILE A 378
LEU A  54
ASP A 364
VAL A  31
 None
 0.79A 4nkxB-1lrtA:
undetectable		 4nkxB-1lrtA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ILE A 378
LEU A  54
ASP A 364
VAL A  31
 None
 0.80A 4nkxB-1mewA:
0.0		 4nkxB-1mewA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 ILE A  16
LEU A 176
ASP A 185
GLU A 190
 None
 1.06A 4nkxB-1mhsA:
0.0		 4nkxB-1mhsA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1paq TRANSLATION
INITIATION FACTOR
EIF-2B EPSILON
SUBUNIT

(Saccharomyces
cerevisiae) 		PF02020
(W2) 		4 ILE A 673
LEU A 700
ASP A 664
GLU A 669
 None
 0.92A 4nkxB-1paqA:
undetectable		 4nkxB-1paqA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 ILE A 392
LEU A 352
ASP A 312
GLU A 362
 None
None
NAD  A 601 (-3.7A)
None
 0.89A 4nkxB-1vkoA:
0.0		 4nkxB-1vkoA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x55 ASPARAGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ILE A 288
LEU A 291
ASP A 303
GLU A 299
 None
None
MG  A2002 ( 4.3A)
None
 0.97A 4nkxB-1x55A:
0.0		 4nkxB-1x55A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		4 ILE A  53
LEU A  49
ASP A 220
GLU A  56
 None
 0.95A 4nkxB-1xt8A:
undetectable		 4nkxB-1xt8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bod ENDOGLUCANASE E-2

(Thermobifida
fusca) 		PF01341
(Glyco_hydro_6) 		4 ILE X 208
LEU X 213
ASP X 176
VAL X 114
 None
 1.03A 4nkxB-2bodX:
undetectable		 4nkxB-2bodX:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		4 ILE A  41
LEU A 288
GLU A 211
VAL A 293
 None
 0.83A 4nkxB-2hg4A:
undetectable		 4nkxB-2hg4A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu1 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5

(Homo sapiens) 		PF02020
(W2) 		4 ILE A 351
LEU A 382
ASP A 342
GLU A 347
 None
 0.93A 4nkxB-2iu1A:
undetectable		 4nkxB-2iu1A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzw ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 ILE A 687
LEU A 601
ASP A 597
VAL A 562
 None
 1.06A 4nkxB-2mzwA:
undetectable		 4nkxB-2mzwA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pm9 PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ILE A  56
LEU A  44
ASP A  18
VAL A 327
 None
 1.04A 4nkxB-2pm9A:
undetectable		 4nkxB-2pm9A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmu RESPONSE REGULATOR
PHOP

(Mycobacterium
tuberculosis) 		PF00486
(Trans_reg_C) 		4 ILE A 225
LEU A 233
GLU A 178
VAL A 213
 None
 0.96A 4nkxB-2pmuA:
undetectable		 4nkxB-2pmuA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pww UNCHARACTERIZED
PROTEIN

(Bacillus
clausii) 		PF08868
(YugN) 		4 ILE A  99
LEU A   1
ASP A   5
VAL A  55
 None
 0.87A 4nkxB-2pwwA:
undetectable		 4nkxB-2pwwA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkd ZINC FINGER PROTEIN
ZPR1

(Mus musculus) 		PF03367
(zf-ZPR1) 		4 ILE A 154
LEU A 182
GLU A 147
VAL A 107
 None
 1.05A 4nkxB-2qkdA:
undetectable		 4nkxB-2qkdA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvg TWO COMPONENT
RESPONSE REGULATOR

(Legionella
pneumophila) 		PF00072
(Response_reg) 		4 ILE A  10
LEU A  64
GLU A  24
VAL A  18
 None
 1.07A 4nkxB-2qvgA:
undetectable		 4nkxB-2qvgA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9z GLUTATHIONE AMIDE
REDUCTASE

(Marichromatium
gracile) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 257
LEU A 181
ASP A 157
VAL A  84
 None
 0.92A 4nkxB-2r9zA:
undetectable		 4nkxB-2r9zA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdu TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE-ASSOCI
ATED WD REPEAT
PROTEIN TRM82

(Saccharomyces
cerevisiae) 		no annotation 5 ILE B 306
LEU B 288
ASP B 262
GLU B 307
VAL B 433
 None
 1.30A 4nkxB-2vduB:
undetectable		 4nkxB-2vduB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		4 ILE A 572
LEU A 456
ASP A 551
VAL A 452
 None
 1.06A 4nkxB-2vsaA:
undetectable		 4nkxB-2vsaA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2s MATRIX PROTEIN

(Lagos bat
lyssavirus) 		PF04785
(Rhabdo_M2) 		4 ILE A 155
LEU A 153
GLU A  58
VAL A 106
 None
 1.05A 4nkxB-2w2sA:
undetectable		 4nkxB-2w2sA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk1 NOVP

(Actinoalloteichus
cyanogriseus) 		PF05711
(TylF) 		4 ILE A 127
LEU A 150
ASP A 196
VAL A 157
 SAH  A 301 ( 4.6A)
None
SAH  A 301 ( 3.5A)
None
 0.84A 4nkxB-2wk1A:
undetectable		 4nkxB-2wk1A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 ILE A 652
LEU A 661
GLU A 605
VAL A 417
 None
 0.88A 4nkxB-2wyhA:
undetectable		 4nkxB-2wyhA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		4 ILE A 303
LEU A 354
GLU A 256
VAL A 253
 None
 0.87A 4nkxB-2z00A:
undetectable		 4nkxB-2z00A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akz GLUTAMYL-TRNA
SYNTHETASE 2

(Thermotoga
maritima) 		no annotation 4 ILE B  63
LEU B  61
GLU B  64
VAL B 214
 None
None
GSU  B1001 (-3.8A)
None
 1.00A 4nkxB-3akzB:
undetectable		 4nkxB-3akzB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8t FUMARATE LYASE

(Chelativorans
sp. BNC1) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 ILE A 302
LEU A 303
ASP A 264
GLU A 278
 None
 0.89A 4nkxB-3c8tA:
undetectable		 4nkxB-3c8tA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 276
LEU A 244
ASP A 234
VAL A 224
 None
 1.06A 4nkxB-3dfhA:
undetectable		 4nkxB-3dfhA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb2 PUTATIVE
DIHYDRODIPICOLINATE
SYNTHETASE

(Rhodopseudomonas
palustris) 		PF00701
(DHDPS) 		4 ILE A 255
LEU A 259
GLU A  50
VAL A  22
 None
 0.96A 4nkxB-3eb2A:
undetectable		 4nkxB-3eb2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb0 PEPTIDASE T

(Bacillus cereus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ILE A  27
LEU A  31
ASP A 108
GLU A  24
 None
 1.03A 4nkxB-3gb0A:
undetectable		 4nkxB-3gb0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ILE A  63
LEU A  66
GLU A  82
VAL A  76
 None
 0.97A 4nkxB-3gdeA:
undetectable		 4nkxB-3gdeA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gon PHOSPHOMEVALONATE
KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N) 		4 ILE A  18
LEU A  19
ASP A 150
GLU A  15
 PMV  A 400 (-4.6A)
PMV  A 400 ( 4.8A)
None
None
 0.90A 4nkxB-3gonA:
undetectable		 4nkxB-3gonA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig4 XAA-PRO
AMINOPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 ILE A 180
LEU A 397
ASP A 174
GLU A 182
 None
 0.99A 4nkxB-3ig4A:
undetectable		 4nkxB-3ig4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ism CG8862

(Drosophila
melanogaster) 		PF01223
(Endonuclease_NS) 		4 ILE A 305
LEU A 302
GLU A 260
VAL A 208
 None
 0.95A 4nkxB-3ismA:
undetectable		 4nkxB-3ismA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iug RHO/CDC42/RAC
GTPASE-ACTIVATING
PROTEIN RICS

(Homo sapiens) 		PF00620
(RhoGAP) 		4 ILE A 486
LEU A 489
GLU A 498
VAL A 385
 None
 0.69A 4nkxB-3iugA:
undetectable		 4nkxB-3iugA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k85 D-GLYCERO-D-MANNO-HE
PTOSE 1-PHOSPHATE
KINASE

(Bacteroides
thetaiotaomicron) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ILE A  36
LEU A  11
GLU A 195
VAL A 250
 None
 1.00A 4nkxB-3k85A:
undetectable		 4nkxB-3k85A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpa PROBABLE UBIQUITIN
FOLD MODIFIER
CONJUGATING ENZYME

(Leishmania
major) 		PF08694
(UFC1) 		4 ILE A 114
LEU A  98
GLU A 148
VAL A 153
 None
 0.88A 4nkxB-3kpaA:
undetectable		 4nkxB-3kpaA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		4 LEU A 271
ASP A 284
GLU A 229
VAL A 241
 AKG  A 702 ( 4.7A)
FE2  A 491 ( 2.6A)
None
None
 0.81A 4nkxB-3kv6A:
undetectable		 4nkxB-3kv6A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ILE A 194
LEU A 173
ASP A 201
GLU A 196
 None
ACT  A  10 (-4.7A)
None
None
 1.02A 4nkxB-3l22A:
undetectable		 4nkxB-3l22A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		4 ILE A 423
LEU A 133
GLU A 425
VAL A 432
 HEM  A 481 (-4.7A)
HEM  A 481 (-4.8A)
None
None
 1.00A 4nkxB-3l4dA:
31.4		 4nkxB-3l4dA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv4 GLYCOSIDE HYDROLASE
YXIA

(Bacillus
licheniformis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 ILE A 403
LEU A 405
GLU A 385
VAL A 452
 None
None
CA  A 504 (-3.0A)
None
 1.00A 4nkxB-3lv4A:
undetectable		 4nkxB-3lv4A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3meq ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Brucella suis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 147
LEU A 302
GLU A  66
VAL A 292
 None
None
None
NAI  A 601 (-3.4A)
 1.01A 4nkxB-3meqA:
undetectable		 4nkxB-3meqA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhg PUTATIVE
PHOPHOTRIESTERASE

(Proteus
mirabilis) 		PF02126
(PTE) 		4 ILE A 101
LEU A  30
ASP A 294
VAL A  77
 UNL  A 374 ( 3.7A)
UNL  A 374 ( 3.6A)
CAC  A 370 (-2.4A)
None
 0.99A 4nkxB-3rhgA:
undetectable		 4nkxB-3rhgA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tth SPERMIDINE
N1-ACETYLTRANSFERASE

(Coxiella
burnetii) 		PF13302
(Acetyltransf_3) 		4 ILE A 115
LEU A 116
GLU A 110
VAL A 165
 None
 1.05A 4nkxB-3tthA:
undetectable		 4nkxB-3tthA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		4 ILE B  87
LEU B  91
GLU B  99
VAL B 540
 None
 0.95A 4nkxB-3u9rB:
undetectable		 4nkxB-3u9rB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upu ATP-DEPENDENT DNA
HELICASE DDA

(Escherichia
virus T4) 		PF13604
(AAA_30) 		4 ILE A  45
LEU A  41
ASP A   4
GLU A  47
 None
 1.01A 4nkxB-3upuA:
undetectable		 4nkxB-3upuA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v42 FOLLICULIN

(Homo sapiens) 		PF16692
(Folliculin_C) 		4 ILE A 482
LEU A 549
GLU A 510
VAL A 517
 None
 1.00A 4nkxB-3v42A:
undetectable		 4nkxB-3v42A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A1709
LEU A1706
ASP A1451
VAL A1516
 None
 0.77A 4nkxB-3va7A:
undetectable		 4nkxB-3va7A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		4 ILE A1123
LEU A1110
ASP A1062
GLU A1069
 None
 1.03A 4nkxB-4amcA:
undetectable		 4nkxB-4amcA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzk PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12931
(Sec16_C) 		4 ILE A  56
LEU A  44
ASP A  18
VAL A 327
 None
 1.03A 4nkxB-4bzkA:
undetectable		 4nkxB-4bzkA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ILE A 130
LEU A 125
ASP A 137
GLU A 132
 None
 0.98A 4nkxB-4c3hA:
undetectable		 4nkxB-4c3hA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4co6 NUCLEOPROTEIN

(Nipah
henipavirus) 		PF00973
(Paramyxo_ncap) 		4 ILE A 155
LEU A 161
GLU A  50
VAL A 104
 None
 1.02A 4nkxB-4co6A:
undetectable		 4nkxB-4co6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 ILE K 297
LEU K 296
ASP K 304
GLU K 298
 None
 1.05A 4nkxB-4cr4K:
undetectable		 4nkxB-4cr4K:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2i HERA

(Sulfolobus
solfataricus) 		PF01935
(DUF87)
PF05872
(DUF853)
PF09378
(HAS-barrel) 		4 ILE A 389
LEU A 387
GLU A 355
VAL A 309
 None
None
MG  A1478 ( 3.9A)
None
 1.03A 4nkxB-4d2iA:
undetectable		 4nkxB-4d2iA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8t GLUCARATE
DEHYDRATASE

(Actinobacillus
succinogenes) 		PF13378
(MR_MLE_C) 		4 ILE A 244
LEU A 248
GLU A 212
VAL A 184
 None
 1.05A 4nkxB-4g8tA:
undetectable		 4nkxB-4g8tA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 ILE A 562
LEU A 560
GLU A 483
VAL A 467
 None
 0.94A 4nkxB-4hvtA:
undetectable		 4nkxB-4hvtA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8o BILE ACID
7A-DEHYDRATASE, BAIE

([Clostridium]
hylemonae) 		PF13577
(SnoaL_4) 		4 ILE A  50
LEU A  46
ASP A 129
GLU A 132
 None
 0.88A 4nkxB-4l8oA:
undetectable		 4nkxB-4l8oA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Cordyceps
militaris) 		PF04909
(Amidohydro_2) 		4 ILE A  30
LEU A  32
ASP A  55
GLU A  50
 None
 0.84A 4nkxB-4lanA:
undetectable		 4nkxB-4lanA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leh BILE ACID 7-ALPHA
DEHYDRATASE, BAIE

([Clostridium]
scindens) 		PF13577
(SnoaL_4) 		4 ILE A  53
LEU A  49
ASP A 131
GLU A 134
 None
 0.81A 4nkxB-4lehA:
undetectable		 4nkxB-4lehA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx8 PERIPLASMIC BINDING
PROTEIN

(Xylanimonas
cellulosilytica) 		PF01497
(Peripla_BP_2) 		4 ILE A  58
LEU A 146
ASP A  51
VAL A  38
 None
 1.01A 4nkxB-4mx8A:
undetectable		 4nkxB-4mx8A:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		5 ILE A 205
LEU A 209
ASP A 298
GLU A 305
VAL A 366
 3QZ  A 601 ( 3.4A)
3QZ  A 601 ( 4.8A)
3QZ  A 601 (-3.5A)
3QZ  A 601 ( 4.9A)
HEM  A 600 ( 3.4A)
 0.22A 4nkxB-4nkyA:
63.5		 4nkxB-4nkyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 ILE B1452
LEU B1371
GLU B1454
VAL B1464
 None
 0.99A 4nkxB-4plbB:
undetectable		 4nkxB-4plbB:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN

(Saccharopolyspora
spinosa) 		PF08241
(Methyltransf_11) 		4 ILE A 160
LEU A 150
GLU A 162
VAL A 129
 None
 1.04A 4nkxB-4pneA:
undetectable		 4nkxB-4pneA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9t NUCLEOPORIN NUP133

(Vanderwaltozyma
polyspora) 		PF08801
(Nucleoporin_N) 		4 ILE A 250
LEU A 248
ASP A 218
GLU A 262
 None
 0.89A 4nkxB-4q9tA:
undetectable		 4nkxB-4q9tA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qor CATALASE

(Bacillus
pumilus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ILE A  40
LEU A  39
ASP A  47
GLU A  41
 None
 0.97A 4nkxB-4qorA:
undetectable		 4nkxB-4qorA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvr UNCHARACTERIZED
HYPOTHETICAL PROTEIN
FTT_1539C

(Francisella
tularensis) 		no annotation 4 ILE A 381
LEU A 385
GLU A 128
VAL A 245
 None
 1.03A 4nkxB-4qvrA:
undetectable		 4nkxB-4qvrA:
21.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		4 ILE A 218
ASP A 309
GLU A 316
VAL A 377
 AER  A 601 ( 4.3A)
AER  A 601 ( 4.1A)
None
HEM  A 600 (-4.6A)
 0.74A 4nkxB-4r1zA:
50.9		 4nkxB-4r1zA:
46.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6h SOLUTE BINDING
PROTEIN MSME

(Bacillus
subtilis) 		PF01547
(SBP_bac_1) 		4 ILE A 104
LEU A 101
GLU A 350
VAL A 347
 None
 0.98A 4nkxB-4r6hA:
undetectable		 4nkxB-4r6hA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rld ASPARTIC PROTEASE
BLA G 2

(Blattella
germanica) 		PF00026
(Asp) 		4 ILE A 114
LEU A 115
ASP A  76
VAL A  39
 None
 0.85A 4nkxB-4rldA:
undetectable		 4nkxB-4rldA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpa PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 ILE A 147
LEU A 152
ASP A 183
GLU A  46
 None
 0.95A 4nkxB-4rpaA:
undetectable		 4nkxB-4rpaA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sli INTRAMOLECULAR
TRANS-SIALIDASE

(Macrobdella
decora) 		PF02973
(Sialidase)
PF13088
(BNR_2) 		4 ILE A 663
LEU A 716
GLU A 718
VAL A 305
 None
 1.02A 4nkxB-4sliA:
undetectable		 4nkxB-4sliA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr6 DNA POLYMERASE III
SUBUNIT BETA

(Bacillus
subtilis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 ILE A 216
LEU A 217
GLU A 212
VAL A 152
 None
 0.82A 4nkxB-4tr6A:
undetectable		 4nkxB-4tr6A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN SAC3

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		4 ILE A 314
LEU A 317
GLU A 280
VAL A 327
 None
 1.03A 4nkxB-4trqA:
undetectable		 4nkxB-4trqA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ILE A 443
LEU A 446
ASP A  60
VAL A 488
 None
 1.04A 4nkxB-4wz9A:
undetectable		 4nkxB-4wz9A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yds FLAGELLA-RELATED
PROTEIN H

(Sulfolobus
acidocaldarius) 		PF06745
(ATPase) 		4 ILE A 126
LEU A 127
GLU A  57
VAL A  53
 None
None
MG  A 902 ( 2.3A)
None
 1.02A 4nkxB-4ydsA:
undetectable		 4nkxB-4ydsA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA

(Escherichia
coli) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		4 ILE D 399
LEU D 427
ASP D 404
VAL D 418
 None
 1.06A 4nkxB-4yg7D:
undetectable		 4nkxB-4yg7D:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zda ISOCITRATE
DEHYDROGENASE (NADP)
ICD2

(Mycolicibacterium
smegmatis) 		PF03971
(IDH) 		4 ILE A 210
LEU A 212
GLU A 209
VAL A 447
 None
 1.00A 4nkxB-4zdaA:
undetectable		 4nkxB-4zdaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cad SM80.1 VICILIN

(Solanum
melongena) 		PF00190
(Cupin_1) 		4 ILE A  72
LEU A 125
ASP A 243
GLU A  70
 None
 1.04A 4nkxB-5cadA:
undetectable		 4nkxB-5cadA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdn DNA GYRASE SUBUNIT A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV) 		4 ILE A 452
LEU A 371
GLU A 454
VAL A 464
 ILE  A 452 ( 0.6A)
LEU  A 371 ( 0.6A)
GLU  A 454 ( 0.6A)
VAL  A 464 ( 0.6A)
 1.00A 4nkxB-5cdnA:
undetectable		 4nkxB-5cdnA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed4 RESPONSE REGULATOR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 ILE A 225
LEU A 233
GLU A 178
VAL A 213
 None
 1.07A 4nkxB-5ed4A:
undetectable		 4nkxB-5ed4A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 ILE A 642
LEU A 663
ASP A 657
VAL A 594
 None
 0.98A 4nkxB-5gr8A:
undetectable		 4nkxB-5gr8A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A1709
LEU A1706
ASP A1451
VAL A1516
 None
 0.78A 4nkxB-5i8iA:
undetectable		 4nkxB-5i8iA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		4 ILE A  85
LEU A  82
GLU A 182
VAL A 189
 None
 1.01A 4nkxB-5izdA:
undetectable		 4nkxB-5izdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 ILE A 448
LEU A 444
GLU A 346
VAL A 468
 None
 1.05A 4nkxB-5jqkA:
undetectable		 4nkxB-5jqkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5a PARB DOMAIN PROTEIN
NUCLEASE

(Sulfolobus
solfataricus) 		PF02195
(ParBc) 		4 ILE B 120
LEU B 116
ASP B  62
GLU B  25
 None
 0.96A 4nkxB-5k5aB:
undetectable		 4nkxB-5k5aB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Trichormus
variabilis) 		PF00701
(DHDPS) 		4 ILE A 255
LEU A 259
GLU A  49
VAL A  21
 None
 1.00A 4nkxB-5ktlA:
undetectable		 4nkxB-5ktlA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN

(Brucella
abortus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat)
PF02954
(HTH_8) 		4 ILE A 338
LEU A 346
GLU A 321
VAL A 143
 None
 0.98A 4nkxB-5m7oA:
undetectable		 4nkxB-5m7oA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n11 HEMAGGLUTININ-ESTERA
SE

(Betacoronavirus
1) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 ILE A 175
LEU A 267
ASP A 190
VAL A 201
 None
None
NAG  A 508 (-3.3A)
None
 0.91A 4nkxB-5n11A:
undetectable		 4nkxB-5n11A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE

(Haemophilus
influenzae) 		PF02219
(MTHFR) 		4 ILE A 261
LEU A 262
ASP A 185
VAL A 212
 None
 1.03A 4nkxB-5umeA:
undetectable		 4nkxB-5umeA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf5 SM80.1 VICILIN

(Solanum
melongena) 		no annotation 4 ILE A  72
LEU A 125
ASP A 242
GLU A  70
 None
 1.04A 4nkxB-5vf5A:
undetectable		 4nkxB-5vf5A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 4 ILE A 412
LEU A 369
GLU A 414
VAL A 242
 None
 1.05A 4nkxB-5w21A:
undetectable		 4nkxB-5w21A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3l VIRAL PROTEIN 3

(Rhinovirus B) 		PF00073
(Rhv) 		4 ILE B  47
LEU B  97
ASP B 216
VAL B 162
 None
 1.07A 4nkxB-5w3lB:
undetectable		 4nkxB-5w3lB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wk0 DAMAGE-INDUCIBLE
PROTEIN DINB

(Staphylococcus
sp. HMSC055H04) 		no annotation 4 ILE A 149
LEU A 150
GLU A 145
VAL A  20
 None
 0.99A 4nkxB-5wk0A:
undetectable		 4nkxB-5wk0A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b23 MAJOR HEAD PROTEIN

(Staphylococcus
virus 80alpha) 		no annotation 4 ILE A  47
LEU A  39
GLU A 128
VAL A  29
 None
 1.01A 4nkxB-6b23A:
undetectable		 4nkxB-6b23A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 4 ILE A  61
LEU A  24
GLU A 130
VAL A 138
 None
 1.03A 4nkxB-6em0A:
undetectable		 4nkxB-6em0A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 4 LEU A 556
ASP A 493
GLU A 551
VAL A 541
 None
 1.01A 4nkxB-6f91A:
undetectable		 4nkxB-6f91A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3d ARGININOSUCCINATE
LYASE

(Chelativorans
sp. BNC1) 		no annotation 4 ILE A 175
LEU A 172
GLU A 258
VAL A 269
 None
 1.01A 4nkxB-6g3dA:
undetectable		 4nkxB-6g3dA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 4 ILE A 619
LEU A 616
GLU A 597
VAL A 548
 None
 0.98A 4nkxB-6g9oA:
undetectable		 4nkxB-6g9oA:
9.11