SIMILAR PATTERNS OF AMINO ACIDS FOR 4NKX_A_STRA601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		4 LEU A 209
ASP A 245
VAL A 256
ALA A 255
 None
 0.98A 4nkxA-1amyA:
0.0		 4nkxA-1amyA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		4 LEU A 249
ASP A 270
GLU A 277
ALA A 323
 None
 0.96A 4nkxA-1eb3A:
0.0		 4nkxA-1eb3A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ga7 HYPOTHETICAL 23.7
KDA PROTEIN IN
ICC-TOLC INTERGENIC
REGION

(Escherichia
coli) 		PF00293
(NUDIX) 		4 LEU A  63
ASP A  70
GLU A 147
ALA A 153
 None
 0.97A 4nkxA-1ga7A:
0.0		 4nkxA-1ga7A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE

(Oryza sativa) 		PF00834
(Ribul_P_3_epim) 		4 LEU A 166
GLU A 161
VAL A 188
ALA A 189
 None
 0.85A 4nkxA-1h1yA:
0.0		 4nkxA-1h1yA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jro XANTHINE
DEHYDROGENASE, CHAIN
A

(Rhodobacter
capsulatus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		4 LEU A 210
ASP A  43
VAL A 278
ALA A 279
 None
FAD  A3005 (-3.7A)
None
FAD  A3005 (-3.6A)
 0.98A 4nkxA-1jroA:
0.0		 4nkxA-1jroA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 LEU A  10
ARG A 272
ASP A 451
ALA A 253
 None
None
MN  A 653 (-3.2A)
None
 1.01A 4nkxA-1ksiA:
0.0		 4nkxA-1ksiA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot8 NEUROGENIC LOCUS
NOTCH PROTEIN

(Drosophila
melanogaster) 		PF12796
(Ank_2) 		4 LEU A 124
ASP A  81
VAL A  99
ALA A  96
 None
 1.01A 4nkxA-1ot8A:
0.0		 4nkxA-1ot8A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ASP A 236
GLU A 230
VAL A 285
ALA A 218
 None
 0.91A 4nkxA-1pvdA:
0.0		 4nkxA-1pvdA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2l PROTEASE III

(Escherichia
coli) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF16187
(Peptidase_M16_M) 		4 LEU A  67
ARG A  42
VAL A  71
ALA A 128
 None
 0.95A 4nkxA-1q2lA:
0.0		 4nkxA-1q2lA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7l AMINOACYLASE-1

(Homo sapiens) 		PF01546
(Peptidase_M20) 		4 ASP A 146
GLU A  53
VAL A  35
ALA A  34
 None
 0.97A 4nkxA-1q7lA:
undetectable		 4nkxA-1q7lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s70 130 KDA
MYOSIN-BINDING
SUBUNIT OF SMOOTH
MUSCLE MYOSIN
PHOPHATASE (M130)

(Gallus gallus) 		PF12796
(Ank_2) 		4 LEU B 217
GLU B 174
VAL B 205
ALA B 202
 None
 0.89A 4nkxA-1s70B:
undetectable		 4nkxA-1s70B:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 LEU A  75
GLU A 190
VAL A 138
ALA A 137
 None
 0.99A 4nkxA-1u1hA:
undetectable		 4nkxA-1u1hA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugs NITRILE HYDRATASE
ALPHA SUBUNIT

(Pseudonocardia
thermophila) 		PF02979
(NHase_alpha) 		5 LEU A  83
ARG A  71
ASP A  65
VAL A 190
ALA A 187
 None
 1.09A 4nkxA-1ugsA:
undetectable		 4nkxA-1ugsA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyo NALP

(Neisseria
meningitidis) 		PF03797
(Autotransporter) 		4 LEU X 987
ASP X 958
VAL X 808
ALA X 807
 None
 1.01A 4nkxA-1uyoX:
undetectable		 4nkxA-1uyoX:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		4 ARG A 174
ASP A 162
VAL A 210
ALA A 212
 None
 0.95A 4nkxA-1xw8A:
undetectable		 4nkxA-1xw8A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwm PHOSPHATE UPTAKE
REGULATOR

(Geobacillus
stearothermophilus) 		PF01895
(PhoU) 		4 LEU A 121
ASP A 115
VAL A 186
ALA A 187
 None
 0.98A 4nkxA-1xwmA:
undetectable		 4nkxA-1xwmA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		4 LEU A 270
ARG A  13
GLU A  20
VAL A 224
 None
 1.01A 4nkxA-2aazA:
undetectable		 4nkxA-2aazA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwj PUTATIVE
ENDONUCLEASE

(Aeropyrum
pernix) 		PF01042
(Ribonuc_L-PSP) 		4 LEU A 111
ASP A  50
VAL A  23
ALA A 115
 None
 0.86A 4nkxA-2cwjA:
undetectable		 4nkxA-2cwjA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghi TRANSPORT PROTEIN

(Plasmodium
yoelii) 		PF00005
(ABC_tran) 		4 LEU A 193
ASP A 136
GLU A 160
ALA A 167
 None
 0.97A 4nkxA-2ghiA:
undetectable		 4nkxA-2ghiA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		4 LEU A 288
GLU A 211
VAL A 293
ALA A 446
 None
 0.78A 4nkxA-2hg4A:
undetectable		 4nkxA-2hg4A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 ASP A 803
GLU A 797
VAL A 754
ALA A 755
 None
 0.69A 4nkxA-2hpiA:
undetectable		 4nkxA-2hpiA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iag PROSTACYCLIN
SYNTHASE

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 427
ASP A  63
VAL A  86
ALA A  85
 None
 1.01A 4nkxA-2iagA:
27.2		 4nkxA-2iagA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		4 ASP A 206
GLU A 223
VAL A 187
ALA A 188
 None
 1.00A 4nkxA-2iu4A:
undetectable		 4nkxA-2iu4A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mc6 RNA POLYMERASE
INHIBITOR P7

(Xanthomonas
virus Xp10) 		no annotation 4 LEU A  22
GLU A  37
VAL A  26
ALA A  13
 None
 0.93A 4nkxA-2mc6A:
undetectable		 4nkxA-2mc6A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q74 INOSITOL-1-MONOPHOSP
HATASE

(Mycobacterium
tuberculosis) 		PF00459
(Inositol_P) 		4 LEU A 164
GLU A 245
VAL A 250
ALA A 266
 None
 0.84A 4nkxA-2q74A:
undetectable		 4nkxA-2q74A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfl INOSITOL-1-MONOPHOSP
HATASE

(Escherichia
coli) 		PF00459
(Inositol_P) 		4 LEU A 140
GLU A 222
VAL A 227
ALA A 244
 None
 0.99A 4nkxA-2qflA:
undetectable		 4nkxA-2qflA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtk PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 LEU A 145
GLU A 141
VAL A 137
ALA A 149
 None
None
C8E  A 395 ( 4.7A)
C8E  A 395 ( 4.4A)
 0.88A 4nkxA-2qtkA:
undetectable		 4nkxA-2qtkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ASP A 236
GLU A 230
VAL A 285
ALA A 218
 None
 0.97A 4nkxA-2vk4A:
undetectable		 4nkxA-2vk4A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 260
GLU A 246
VAL A 284
ALA A 286
 None
 0.97A 4nkxA-2wekA:
undetectable		 4nkxA-2wekA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y30 PUTATIVE REPRESSOR
SIMREG2

(Streptomyces
antibioticus) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 LEU A 110
ASP A  80
VAL A  45
ALA A  40
 None
None
CL  A1247 (-4.7A)
None
 0.89A 4nkxA-2y30A:
undetectable		 4nkxA-2y30A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13469
(Sulfotransfer_3) 		4 ARG A 212
ASP A 178
VAL A  13
ALA A  10
 None
 0.98A 4nkxA-2z6vA:
undetectable		 4nkxA-2z6vA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN

(Escherichia
coli) 		PF05985
(EutC)
PF06751
(EutB) 		4 LEU A 402
ASP A 168
VAL B  75
ALA B  76
 B12  B 601 (-4.5A)
None
None
None
 1.02A 4nkxA-3anyA:
undetectable		 4nkxA-3anyA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eli AHA1 DOMAIN PROTEIN

(Ruegeria
pomeroyi) 		PF08327
(AHSA1) 		4 ASP A  23
GLU A 146
VAL A  12
ALA A  13
 None
 1.00A 4nkxA-3eliA:
undetectable		 4nkxA-3eliA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF03740
(PdxJ) 		4 ARG A 139
ASP A 108
VAL A 120
ALA A 119
 None
 1.01A 4nkxA-3f4nA:
undetectable		 4nkxA-3f4nA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA

(Methanocaldococcus
jannaschii) 		PF00282
(Pyridoxal_deC) 		4 ASP A 187
GLU A 191
VAL A 166
ALA A 165
 None
 0.86A 4nkxA-3f9tA:
undetectable		 4nkxA-3f9tA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feh CENTAURIN-ALPHA-1

(Homo sapiens) 		PF00169
(PH)
PF01412
(ArfGap) 		4 LEU A 103
ASP A 220
VAL A 197
ALA A 182
 None
 0.87A 4nkxA-3fehA:
undetectable		 4nkxA-3fehA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger) 		PF06441
(EHN) 		4 LEU A 300
GLU A 123
VAL A 146
ALA A  99
 None
 0.98A 4nkxA-3g0iA:
undetectable		 4nkxA-3g0iA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9p PUTATIVE
TRIPHOSPHORIBOSYL-DE
PHOSPHO-COA SYNTHASE

(Archaeoglobus
fulgidus) 		PF01874
(CitG) 		4 ASP A 121
GLU A 127
VAL A  71
ALA A  70
 None
 0.90A 4nkxA-3h9pA:
undetectable		 4nkxA-3h9pA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjp PEROXIREDOXIN,
BACTERIOFERRITIN
COMIGRATORY PROTEIN
HOMOLOG (BCP-4)

(Sulfolobus
solfataricus) 		PF00578
(AhpC-TSA) 		4 LEU A 108
ASP A  72
VAL A 104
ALA A 105
 None
 0.97A 4nkxA-3hjpA:
undetectable		 4nkxA-3hjpA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		4 LEU A  41
GLU A  48
VAL A  74
ALA A  76
 None
 0.89A 4nkxA-3i45A:
undetectable		 4nkxA-3i45A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilw DNA GYRASE SUBUNIT A

(Mycobacterium
tuberculosis) 		PF00521
(DNA_topoisoIV) 		4 ASP A 209
GLU A 212
VAL A 219
ALA A 218
 None
 0.97A 4nkxA-3ilwA:
undetectable		 4nkxA-3ilwA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8r UNCHARACTERIZED
PROTEIN

(Rhodospirillum
rubrum) 		PF10387
(DUF2442) 		4 LEU A  58
ASP A  86
VAL A  40
ALA A  29
 None
 1.01A 4nkxA-3k8rA:
undetectable		 4nkxA-3k8rA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE

(Saccharomyces
cerevisiae) 		PF00282
(Pyridoxal_deC) 		4 LEU C 495
GLU C 490
VAL C 509
ALA C 510
 None
 0.90A 4nkxA-3mc6C:
undetectable		 4nkxA-3mc6C:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mml ALLOPHANATE
HYDROLASE SUBUNIT 2

(Mycolicibacterium
smegmatis) 		PF02626
(CT_A_B) 		5 LEU A  19
ARG A 234
ASP A  36
GLU A  17
ALA A 118
 None
 1.08A 4nkxA-3mmlA:
undetectable		 4nkxA-3mmlA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtx PROTEIN MD-1

(Gallus gallus) 		PF02221
(E1_DerP2_DerF2) 		4 LEU A  76
GLU A  94
VAL A  80
ALA A 137
 None
None
None
PGT  A 300 ( 3.9A)
 1.00A 4nkxA-3mtxA:
undetectable		 4nkxA-3mtxA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 LEU A 315
GLU A 320
VAL A 284
ALA A 285
 None
 0.98A 4nkxA-3ne5A:
3.1		 4nkxA-3ne5A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE

(Clostridioides
difficile) 		PF06050
(HGD-D) 		4 LEU A 193
GLU A 232
VAL A  10
ALA A   7
 None
 0.90A 4nkxA-3o3oA:
undetectable		 4nkxA-3o3oA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqq PUTATIVE LIPOPROTEIN

(Bacteroides
ovatus) 		PF16129
(DUF4841)
PF16130
(DUF4842) 		4 LEU A 320
ASP A 293
VAL A 324
ALA A 231
 None
PGE  A 462 ( 4.4A)
None
None
 1.02A 4nkxA-3oqqA:
undetectable		 4nkxA-3oqqA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ova CCA-ADDING ENZYME

(Archaeoglobus
fulgidus) 		PF01909
(NTP_transf_2)
PF09249
(tRNA_NucTransf2) 		4 LEU A 155
GLU A 176
VAL A 226
ALA A 227
 None
 0.98A 4nkxA-3ovaA:
undetectable		 4nkxA-3ovaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p11 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 ARG A 162
ASP A 159
VAL A  70
ALA A  71
 None
 0.91A 4nkxA-3p11A:
undetectable		 4nkxA-3p11A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnn CONSERVED DOMAIN
PROTEIN

(Porphyromonas
gingivalis) 		no annotation 4 ARG A 165
ASP A 122
VAL A 104
ALA A 103
 GOL  A 304 (-4.4A)
GOL  A 304 ( 3.1A)
None
None
 0.97A 4nkxA-3pnnA:
undetectable		 4nkxA-3pnnA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		4 ARG A 236
ASP A  96
VAL A 139
ALA A 127
 None
 1.01A 4nkxA-3q6tA:
undetectable		 4nkxA-3q6tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3j GLUTAMATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ARG A  74
GLU A  93
VAL A 489
ALA A 490
 None
 0.99A 4nkxA-3r3jA:
undetectable		 4nkxA-3r3jA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		4 LEU A 246
GLU A 218
VAL A 212
ALA A 242
 None
 0.85A 4nkxA-3uboA:
undetectable		 4nkxA-3uboA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umb DEHALOGENASE-LIKE
HYDROLASE

(Ralstonia
solanacearum) 		PF00702
(Hydrolase) 		4 LEU A  79
ASP A  42
VAL A  21
ALA A  22
 None
MG  A 240 (-2.8A)
None
None
 0.87A 4nkxA-3umbA:
undetectable		 4nkxA-3umbA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Sphingomonas
wittichii) 		PF00903
(Glyoxalase) 		4 LEU A  45
GLU A 213
VAL A 220
ALA A 223
 None
 0.89A 4nkxA-3vb0A:
undetectable		 4nkxA-3vb0A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vk5 MOEO5

(Streptomyces
viridosporus) 		PF01884
(PcrB) 		4 LEU A 200
GLU A 182
VAL A 129
ALA A 119
 None
 0.98A 4nkxA-3vk5A:
undetectable		 4nkxA-3vk5A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtd UNCHARACTERIZED
PROTEIN C9ORF142

(Homo sapiens) 		PF15384
(PAXX) 		4 ARG A  63
ASP A 108
VAL A  85
ALA A  86
 None
 0.87A 4nkxA-3wtdA:
undetectable		 4nkxA-3wtdA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwk SNACLEC RHODOCYTIN
SUBUNIT ALPHA

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		4 LEU A 134
ASP A  13
VAL A 130
ALA A  43
 None
 1.01A 4nkxA-3wwkA:
undetectable		 4nkxA-3wwkA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apb FUMARATE HYDRATASE
CLASS II

(Mycobacterium
tuberculosis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 LEU A 376
ASP A 344
GLU A 371
ALA A 151
 None
 0.98A 4nkxA-4apbA:
2.5		 4nkxA-4apbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		4 LEU B 783
ASP B 743
VAL B 677
ALA B 678
 None
 0.96A 4nkxA-4b93B:
undetectable		 4nkxA-4b93B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ARG A 409
ASP A 454
VAL A 297
ALA A 438
 None
 0.91A 4nkxA-4bc5A:
undetectable		 4nkxA-4bc5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2z TCAB9

(Micromonospora
chalcea) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 ARG A 259
ASP A  96
VAL A 128
ALA A 126
 None
 0.91A 4nkxA-4e2zA:
undetectable		 4nkxA-4e2zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eex ALCOHOL
DEHYDROGENASE 1

(Lactococcus
lactis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A  31
GLU A  28
VAL A 115
ALA A 111
 None
 1.00A 4nkxA-4eexA:
undetectable		 4nkxA-4eexA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkv ALCOHOL
DEHYDROGENASE,
PROPANOL-PREFERRING

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A  29
GLU A  26
VAL A 113
ALA A 109
 None
 0.99A 4nkxA-4gkvA:
undetectable		 4nkxA-4gkvA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi0 UREASE ACCESSORY
PROTEIN UREG

(Helicobacter
pylori) 		PF02492
(cobW) 		4 ASP E  74
GLU E 111
VAL E  82
ALA E  81
 None
 0.99A 4nkxA-4hi0E:
undetectable		 4nkxA-4hi0E:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuk NREA PROTEIN

(Staphylococcus
carnosus) 		PF13185
(GAF_2) 		4 LEU A 144
GLU A  24
VAL A 107
ALA A 108
 None
 1.00A 4nkxA-4iukA:
undetectable		 4nkxA-4iukA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		4 ARG A 574
ASP A 407
VAL A 418
ALA A 417
 None
 0.79A 4nkxA-4jlcA:
undetectable		 4nkxA-4jlcA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ASP A 249
GLU A 219
VAL A 231
ALA A 232
 None
 0.96A 4nkxA-4jr7A:
undetectable		 4nkxA-4jr7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jvh PROTEIN QUAKING

(Homo sapiens) 		PF00013
(KH_1)
PF16544
(STAR_dimer) 		4 LEU A  72
GLU A 165
VAL A 172
ALA A 171
 SO4  A 301 ( 4.4A)
None
None
None
 0.90A 4nkxA-4jvhA:
undetectable		 4nkxA-4jvhA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lim DNA PRIMASE SMALL
SUBUNIT

(Saccharomyces
cerevisiae) 		PF01896
(DNA_primase_S) 		4 LEU A 229
ASP A 278
GLU A 272
ALA A 241
 None
 0.98A 4nkxA-4limA:
undetectable		 4nkxA-4limA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzv EPITHELIAL CELL
ADHESION MOLECULE

(Homo sapiens) 		PF00086
(Thyroglobulin_1) 		4 LEU A 242
GLU A 169
VAL A 212
ALA A 213
 DMU  A 301 ( 4.6A)
None
None
None
 0.87A 4nkxA-4mzvA:
undetectable		 4nkxA-4mzvA:
19.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		6 LEU A 209
ARG A 239
ASP A 298
GLU A 305
VAL A 366
ALA A 367
 3QZ  A 601 ( 4.8A)
3QZ  A 601 ( 4.4A)
3QZ  A 601 (-3.5A)
3QZ  A 601 ( 4.9A)
HEM  A 600 ( 3.4A)
HEM  A 600 ( 3.1A)
 0.18A 4nkxA-4nkyA:
63.6		 4nkxA-4nkyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ob1 COBALT-CONTAINING
NITRILE HYDRATASE
SUBUNIT ALPHA

(Pseudonocardia
thermophila) 		PF02979
(NHase_alpha) 		5 LEU A  83
ARG A  71
ASP A  65
VAL A 190
ALA A 187
 None
 1.15A 4nkxA-4ob1A:
undetectable		 4nkxA-4ob1A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb9 AB64 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  11
ASP H 173
GLU H 148
ALA H 118
 None
 0.93A 4nkxA-4pb9H:
undetectable		 4nkxA-4pb9H:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu6 L-ASPARAGINASE BETA
SUBUNIT

(Phaseolus
vulgaris) 		PF01112
(Asparaginase_2) 		4 LEU B 270
GLU B 260
VAL B 243
ALA B 293
 None
 0.95A 4nkxA-4pu6B:
undetectable		 4nkxA-4pu6B:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3l MGS-M2

(unidentified) 		PF00561
(Abhydrolase_1) 		4 LEU A 180
ARG A 173
VAL A 140
ALA A 141
 None
 1.00A 4nkxA-4q3lA:
undetectable		 4nkxA-4q3lA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIM

(Thermotoga
maritima) 		PF02154
(FliM) 		4 LEU A 223
ASP A 108
GLU A 111
ALA A 114
 None
 0.94A 4nkxA-4qrmA:
undetectable		 4nkxA-4qrmA:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		4 ARG A 252
ASP A 309
GLU A 316
VAL A 377
 None
AER  A 601 ( 4.1A)
None
HEM  A 600 (-4.6A)
 0.85A 4nkxA-4r1zA:
50.5		 4nkxA-4r1zA:
46.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8z CYCLIC DI-GMP
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF13487
(HD_5) 		4 ASP A 310
GLU A 185
VAL A 360
ALA A 361
 NI  A 401 ( 4.5A)
None
CL  A 403 ( 4.1A)
None
 0.95A 4nkxA-4r8zA:
undetectable		 4nkxA-4r8zA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		5 ARG A 365
ASP A 255
GLU A 249
VAL A 284
ALA A 283
 None
MG  A3003 ( 2.9A)
None
None
None
 1.50A 4nkxA-4rxeA:
undetectable		 4nkxA-4rxeA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2p KETOSYNTHASE

(Myxococcus
fulvus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 319
GLU A 129
VAL A 117
ALA A  86
 None
 0.88A 4nkxA-4v2pA:
undetectable		 4nkxA-4v2pA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcx BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED

(Thermoanaerobacter
italicus) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		4 LEU A 310
ARG A 273
VAL A 298
ALA A 297
 None
 0.96A 4nkxA-4wcxA:
undetectable		 4nkxA-4wcxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wja UNCHARACTERIZED
PROTEIN C9ORF142

(Homo sapiens) 		PF15384
(PAXX) 		4 ARG A  63
ASP A 108
VAL A  85
ALA A  86
 None
 0.90A 4nkxA-4wjaA:
undetectable		 4nkxA-4wjaA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE
ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNH

(Escherichia
coli) 		PF05845
(PhnH)
PF06007
(PhnJ) 		4 LEU B 138
GLU B  27
VAL D  28
ALA D  29
 None
 0.80A 4nkxA-4xb6B:
undetectable		 4nkxA-4xb6B:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi0 MAGNETOSOME PROTEIN
MAMA

(Desulfovibrio
magneticus) 		PF07719
(TPR_2)
PF13432
(TPR_16) 		4 LEU A 129
ASP A 101
VAL A 137
ALA A 136
 None
 0.96A 4nkxA-4xi0A:
undetectable		 4nkxA-4xi0A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Helicobacter
pylori) 		PF00793
(DAHP_synth_1) 		4 LEU A 238
GLU A 172
VAL A 233
ALA A 232
 None
 1.01A 4nkxA-4z1aA:
undetectable		 4nkxA-4z1aA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		4 ARG A  47
GLU A 271
VAL A 275
ALA A 274
 None
 0.84A 4nkxA-4zm6A:
undetectable		 4nkxA-4zm6A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00632
(HECT) 		4 LEU A 780
ARG A 658
ASP A 769
VAL A 646
 None
 0.81A 4nkxA-5c91A:
undetectable		 4nkxA-5c91A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		4 LEU A 884
ARG A 868
GLU A 863
ALA A 856
 None
 1.00A 4nkxA-5csaA:
undetectable		 4nkxA-5csaA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8h 50S RIBOSOMAL
PROTEIN L11

(Methanocaldococcus
jannaschii) 		PF00298
(Ribosomal_L11)
PF03946
(Ribosomal_L11_N) 		4 ASP C 140
GLU C 137
VAL C 152
ALA C 150
 None
 0.99A 4nkxA-5d8hC:
undetectable		 4nkxA-5d8hC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5di3 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
13B

(Chlamydomonas
reinhardtii) 		PF00025
(Arf) 		5 LEU B  58
ASP B  69
GLU B  66
VAL B  87
ALA B  89
 None
MG  B 302 ( 3.8A)
None
None
None
 1.44A 4nkxA-5di3B:
undetectable		 4nkxA-5di3B:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF03740
(PdxJ) 		4 ARG A 150
ASP A 119
VAL A 131
ALA A 130
 None
 0.99A 4nkxA-5dlcA:
undetectable		 4nkxA-5dlcA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5en6 SMU-1

(Caenorhabditis
elegans) 		no annotation 4 LEU A 106
ASP A  76
VAL A  97
ALA A  98
 None
 0.82A 4nkxA-5en6A:
undetectable		 4nkxA-5en6A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli) 		PF01204
(Trehalase) 		4 LEU A 188
ARG A 313
VAL A 301
ALA A 300
 None
 1.00A 4nkxA-5gw7A:
undetectable		 4nkxA-5gw7A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6e ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		4 LEU A 884
ARG A 868
GLU A 863
ALA A 856
 None
 0.92A 4nkxA-5i6eA:
undetectable		 4nkxA-5i6eA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7z LD29223P

(Drosophila
melanogaster) 		PF00595
(PDZ) 		4 LEU A 163
ARG A 159
ASP A 216
VAL A 234
 None
 1.00A 4nkxA-5i7zA:
undetectable		 4nkxA-5i7zA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0b MYELOID CELL SURFACE
ANTIGEN CD33

(Homo sapiens) 		PF00047
(ig)
PF07686
(V-set) 		4 ASP A 107
GLU A  85
VAL A  73
ALA A  74
 None
 0.98A 4nkxA-5j0bA:
undetectable		 4nkxA-5j0bA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktz VP1

(Enterovirus C) 		PF00073
(Rhv) 		4 ASP 1 171
GLU 1 168
VAL 1 107
ALA 1 106
 None
 1.01A 4nkxA-5ktz1:
undetectable		 4nkxA-5ktz1:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td7 ZGC:55652

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 ASP A  22
GLU A  28
VAL A 148
ALA A 143
 None
 0.93A 4nkxA-5td7A:
undetectable		 4nkxA-5td7A:
22.05