SIMILAR PATTERNS OF AMINO ACIDS FOR 4NKV_D_AERD601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		4 GLY A 283
ASP A 284
GLU A 292
VAL A 243
 None
 0.98A 4nkvD-1aj8A:
0.0		 4nkvD-1aj8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 GLY A 496
ASP A 497
GLU A 502
VAL A 155
 None
 0.96A 4nkvD-1ebvA:
0.0		 4nkvD-1ebvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ew3 ALLERGEN EQU C 1

(Equus caballus) 		PF00061
(Lipocalin) 		4 TYR A 103
GLY A  54
GLU A 137
VAL A 157
 None
 1.15A 4nkvD-1ew3A:
undetectable		 4nkvD-1ew3A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmc PROTEIN (REPLICATION
PROTEIN A (RPA))

(Homo sapiens) 		PF01336
(tRNA_anti-codon)
PF16900
(REPA_OB_2) 		4 GLY A 231
ASP A 228
GLU A 225
VAL A 251
 None
 1.17A 4nkvD-1jmcA:
0.0		 4nkvD-1jmcA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lr0 TOLA PROTEIN

(Pseudomonas
aeruginosa) 		PF13103
(TonB_2) 		4 GLY A  28
ASP A  31
GLU A  96
VAL A  91
 None
 1.10A 4nkvD-1lr0A:
undetectable		 4nkvD-1lr0A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF01798
(Nop) 		4 GLY B 249
ASP B 245
GLU B  84
VAL B  89
 None
 0.73A 4nkvD-1nt2B:
0.0		 4nkvD-1nt2B:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A  99
ASP A 100
GLU A 156
VAL A  26
 None
 1.12A 4nkvD-1ozhA:
0.0		 4nkvD-1ozhA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5m SIR4-INTERACTING
PROTEIN SIF2

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 TYR A 469
GLY A 422
ASP A 421
VAL A 364
 None
 1.16A 4nkvD-1r5mA:
undetectable		 4nkvD-1r5mA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r75 HYPOTHETICAL PROTEIN

(Leishmania
major) 		PF09149
(DUF1935) 		4 GLY A  17
ASP A  50
GLU A 103
VAL A  58
 None
 1.11A 4nkvD-1r75A:
0.0		 4nkvD-1r75A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgi GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 GLY G 148
ASP G  96
GLU G  47
VAL G  69
 None
 0.94A 4nkvD-1rgiG:
undetectable		 4nkvD-1rgiG:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4

(Homo sapiens;
Mus musculus) 		PF00626
(Gelsolin)
PF01290
(Thymosin) 		4 GLY G 148
ASP G  96
GLU G  47
VAL G  69
 None
 0.94A 4nkvD-1t44G:
undetectable		 4nkvD-1t44G:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		4 TYR A 583
GLY A 548
ASP A 594
GLU A 588
 None
 1.09A 4nkvD-1wacA:
undetectable		 4nkvD-1wacA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvg CDP-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		4 GLY A 202
ASP A 203
GLU A 218
VAL A 223
 None
 1.06A 4nkvD-1wvgA:
undetectable		 4nkvD-1wvgA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9c SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 TYR A 258
GLY A 157
ASP A 156
VAL A 287
 None
 1.17A 4nkvD-2a9cA:
undetectable		 4nkvD-2a9cA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbh DIVALENT CATION
TRANSPORT-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01544
(CorA) 		4 GLY A 144
ASP A 145
GLU A 141
VAL A 109
 NA  A 301 (-4.1A)
None
None
None
 1.16A 4nkvD-2bbhA:
undetectable		 4nkvD-2bbhA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bol SMALL HEAT SHOCK
PROTEIN

(Taenia saginata) 		PF00011
(HSP20) 		4 GLY A 110
ASP A 109
GLU A 105
VAL A 182
 None
 0.98A 4nkvD-2bolA:
undetectable		 4nkvD-2bolA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dxq ACETYLTRANSFERASE

(Agrobacterium
fabrum) 		PF00583
(Acetyltransf_1) 		4 GLY A  14
ASP A  15
GLU A  21
VAL A  88
 None
 1.17A 4nkvD-2dxqA:
undetectable		 4nkvD-2dxqA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ff6 GELSOLIN

(Homo sapiens) 		PF00626
(Gelsolin) 		4 GLY G 148
ASP G  96
GLU G  47
VAL G  69
 None
 1.00A 4nkvD-2ff6G:
undetectable		 4nkvD-2ff6G:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdn ELONGATION FACTOR
EF-TU

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 GLY B  83
ASP B  86
GLU B 117
VAL B 125
 None
 1.08A 4nkvD-2hdnB:
undetectable		 4nkvD-2hdnB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus) 		no annotation 4 TYR A 377
GLY A 122
GLU A  61
VAL A 108
 None
 1.12A 4nkvD-2hihA:
undetectable		 4nkvD-2hihA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j87 THYMIDINE KINASE

(Vaccinia virus) 		PF00265
(TK) 		4 TYR A 166
GLY A 111
ASP A 110
GLU A  83
 TTP  A 300 (-4.0A)
None
None
TTP  A 300 (-3.9A)
 1.01A 4nkvD-2j87A:
undetectable		 4nkvD-2j87A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohd PROBABLE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN
C

(Sulfurisphaera
tokodaii) 		PF01967
(MoaC) 		4 TYR A 122
GLY A  43
ASP A  44
VAL A  88
 None
 0.87A 4nkvD-2ohdA:
undetectable		 4nkvD-2ohdA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 GLY A 232
ASP A 234
GLU A 215
VAL A 135
 None
 0.93A 4nkvD-2p2mA:
undetectable		 4nkvD-2p2mA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE

(Agrobacterium
fabrum) 		PF03562
(MltA)
PF06725
(3D) 		4 GLY A 197
ASP A 196
GLU A 105
VAL A 113
 None
 1.14A 4nkvD-2pnwA:
undetectable		 4nkvD-2pnwA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qts ACID-SENSING ION
CHANNEL

(Gallus gallus) 		PF00858
(ASC) 		4 GLY A 432
ASP A 433
GLU A 426
VAL A  75
 None
 1.16A 4nkvD-2qtsA:
undetectable		 4nkvD-2qtsA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0j BIFUNCTIONAL PROTEIN
GLMU

(Haemophilus
influenzae) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 TYR A 139
GLY A 225
ASP A 105
VAL A 100
 None
None
H2U  A1453 (-2.7A)
None
 1.15A 4nkvD-2v0jA:
undetectable		 4nkvD-2v0jA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		4 GLY A  89
ASP A 120
GLU A 199
VAL A 162
 None
CD  A1218 (-2.1A)
None
None
 1.06A 4nkvD-2vg9A:
undetectable		 4nkvD-2vg9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvt GLUTAMATE RACEMASE

(Enterococcus
faecalis) 		PF01177
(Asp_Glu_race) 		4 GLY A  15
ASP A  11
GLU A  22
VAL A 216
 I24  A1269 ( 3.8A)
DGL  A1270 (-3.4A)
None
None
 0.95A 4nkvD-2vvtA:
undetectable		 4nkvD-2vvtA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt0 HALOALKANE
DEHALOGENASE

(Plesiocystis
pacifica) 		PF00561
(Abhydrolase_1) 		4 GLY A  54
ASP A 123
GLU A 282
VAL A 273
 None
 1.00A 4nkvD-2xt0A:
undetectable		 4nkvD-2xt0A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 TYR A 163
GLY A 140
ASP A 278
VAL A 197
 None
 1.15A 4nkvD-2yheA:
undetectable		 4nkvD-2yheA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N

(Thermus
thermophilus) 		PF00578
(AhpC-TSA) 		4 GLY A  23
ASP A  20
GLU A  17
VAL A 108
 None
 1.08A 4nkvD-2ywoA:
undetectable		 4nkvD-2ywoA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 TYR A 102
GLY A  89
ASP A  88
VAL A  16
 None
 1.07A 4nkvD-2yzmA:
undetectable		 4nkvD-2yzmA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a57 THERMOSTABLE DIRECT
HEMOLYSIN 2

(Vibrio
parahaemolyticus) 		PF03347
(TDH) 		4 TYR A 140
GLY A 145
ASP A  14
VAL A 110
 None
 1.11A 4nkvD-3a57A:
undetectable		 4nkvD-3a57A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 TYR A  34
GLY A 354
ASP A 351
GLU A 347
 None
 1.02A 4nkvD-3ai7A:
undetectable		 4nkvD-3ai7A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR

(Bacillus
subtilis) 		PF04198
(Sugar-bind) 		4 GLY A 115
ASP A 329
GLU A  98
VAL A 325
 None
 1.17A 4nkvD-3bxhA:
undetectable		 4nkvD-3bxhA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dci ARYLESTERASE

(Agrobacterium
fabrum) 		PF13472
(Lipase_GDSL_2) 		4 GLY A  49
ASP A   9
GLU A  46
VAL A  83
 ACY  A 220 ( 3.8A)
ACY  A 220 (-3.6A)
None
None
 0.82A 4nkvD-3dciA:
undetectable		 4nkvD-3dciA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eli AHA1 DOMAIN PROTEIN

(Ruegeria
pomeroyi) 		PF08327
(AHSA1) 		4 GLY A  24
ASP A  23
GLU A 142
VAL A  12
 None
 1.09A 4nkvD-3eliA:
undetectable		 4nkvD-3eliA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk8 DISULPHIDE ISOMERASE

(Xylella
fastidiosa) 		PF13899
(Thioredoxin_7) 		4 TYR A 121
GLY A 125
ASP A 105
VAL A  86
 None
 1.07A 4nkvD-3fk8A:
undetectable		 4nkvD-3fk8A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gon PHOSPHOMEVALONATE
KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N) 		4 TYR A  11
GLY A 146
ASP A 144
VAL A 115
 PMV  A 400 (-4.0A)
PMV  A 400 (-3.4A)
None
None
 0.80A 4nkvD-3gonA:
undetectable		 4nkvD-3gonA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
VITAMIN K-DEPENDENT
PROTEIN Z

(Homo sapiens) 		PF00008
(EGF)
PF00079
(Serpin)
PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		4 TYR A 240
GLY B  96
ASP B  95
GLU B  92
 None
 0.94A 4nkvD-3h5cA:
undetectable		 4nkvD-3h5cA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdt PUTATIVE KINASE

([Clostridium]
symbiosum) 		PF13189
(Cytidylate_kin2) 		4 TYR A 191
GLY A 119
GLU A  19
VAL A 151
 None
CL  A 302 ( 3.7A)
None
None
 1.14A 4nkvD-3hdtA:
undetectable		 4nkvD-3hdtA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iib PEPTIDASE M28

(Shewanella
amazonensis) 		PF04389
(Peptidase_M28) 		4 GLY A  63
ASP A  67
GLU A 327
VAL A 297
 None
None
ZN  A   1 (-2.0A)
None
 1.17A 4nkvD-3iibA:
undetectable		 4nkvD-3iibA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 TYR A 361
GLY A  15
ASP A 167
VAL A 228
 None
 1.11A 4nkvD-3imlA:
undetectable		 4nkvD-3imlA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 GLY A 340
ASP A 339
GLU A 455
VAL A 412
 None
 1.02A 4nkvD-3k30A:
undetectable		 4nkvD-3k30A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6y CATENIN DELTA-1

(Homo sapiens) 		PF00514
(Arm) 		4 GLY A 553
ASP A 556
GLU A 550
VAL A 590
 None
 1.15A 4nkvD-3l6yA:
undetectable		 4nkvD-3l6yA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12979
(DUF3863)
PF12980
(DUF3864) 		4 GLY A 112
ASP A 111
GLU A 118
VAL A  84
 None
 0.90A 4nkvD-3lm3A:
undetectable		 4nkvD-3lm3A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 TYR B 355
GLY A 313
ASP A 231
VAL A 376
 None
 1.10A 4nkvD-3mm5B:
undetectable		 4nkvD-3mm5B:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqp SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLY A 421
ASP A 422
GLU A 415
VAL A 409
 None
 1.10A 4nkvD-3nqpA:
undetectable		 4nkvD-3nqpA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r18 SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 TYR A 258
GLY A 157
ASP A 156
VAL A 287
 None
 1.15A 4nkvD-3r18A:
undetectable		 4nkvD-3r18A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5x D-ALANINE--D-ALANINE
LIGASE

(Bacillus
anthracis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 TYR A  81
GLY A  68
ASP A  67
VAL A  16
 None
 1.03A 4nkvD-3r5xA:
undetectable		 4nkvD-3r5xA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8e HYPOTHETICAL SUGAR
KINASE

(Cytophaga
hutchinsonii) 		PF00480
(ROK) 		4 GLY A 290
ASP A   6
GLU A 106
VAL A  76
 None
 1.09A 4nkvD-3r8eA:
undetectable		 4nkvD-3r8eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlf MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALG

(Escherichia
coli) 		PF00528
(BPD_transp_1) 		4 GLY G 196
ASP G 195
GLU G 189
VAL G 294
 None
 1.07A 4nkvD-3rlfG:
undetectable		 4nkvD-3rlfG:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 TYR A 378
GLY A  16
ASP A 179
VAL A 245
 None
 1.07A 4nkvD-3rv2A:
undetectable		 4nkvD-3rv2A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkt CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 GLY A 133
ASP A 132
GLU A 388
VAL A 306
 None
None
HEM  A 431 ( 4.7A)
None
 1.03A 4nkvD-3tktA:
29.7		 4nkvD-3tktA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		4 TYR A 322
GLY A 166
ASP A 167
VAL A 278
 None
None
MG  A 446 ( 2.7A)
None
 1.06A 4nkvD-3upyA:
undetectable		 4nkvD-3upyA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans) 		PF13199
(Glyco_hydro_66) 		4 TYR A 560
GLY A 222
GLU A 557
VAL A 524
 None
 1.16A 4nkvD-3vmnA:
undetectable		 4nkvD-3vmnA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpc PUTATIVE
ACETYLORNITHINE
DEACETYLASE

(Sulfurisphaera
tokodaii) 		PF08443
(RimK) 		4 TYR A 275
GLY A 231
GLU A 185
VAL A 214
 None
 1.11A 4nkvD-3vpcA:
undetectable		 4nkvD-3vpcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		4 GLY A 220
ASP A 188
GLU A  90
VAL A 121
 None
 1.10A 4nkvD-3vywA:
undetectable		 4nkvD-3vywA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 TYR A 540
GLY A 547
ASP A 476
VAL A 591
 A12  A1598 (-3.4A)
None
None
None
 1.00A 4nkvD-3zu0A:
undetectable		 4nkvD-3zu0A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus cereus) 		PF00268
(Ribonuc_red_sm) 		4 TYR A 166
GLY A 264
GLU A 161
VAL A  73
 None
 1.10A 4nkvD-4bmrA:
undetectable		 4nkvD-4bmrA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 TYR A 477
GLY A 324
ASP A 325
VAL A 236
 None
 0.89A 4nkvD-4cnsA:
undetectable		 4nkvD-4cnsA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 TYR A 477
GLY A 324
ASP A 325
VAL A 236
 None
 0.87A 4nkvD-4cntA:
undetectable		 4nkvD-4cntA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 GLY H 342
ASP H 341
GLU H 335
VAL H 314
 None
 1.08A 4nkvD-4cr4H:
undetectable		 4nkvD-4cr4H:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE

(Polaromonas sp.
JS666) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 GLY A 236
ASP A 240
GLU A 232
VAL A 252
 None
 0.93A 4nkvD-4dllA:
undetectable		 4nkvD-4dllA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftd UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF15416
(DUF4623) 		4 TYR A 272
GLY A 267
ASP A 268
VAL A 339
 None
 1.09A 4nkvD-4ftdA:
undetectable		 4nkvD-4ftdA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2b SECRETED EFFECTOR
PROTEIN SSEI

(Salmonella
enterica) 		PF15645
(Tox-PLDMTX) 		4 TYR A 199
GLY A 221
ASP A 227
VAL A 302
 None
 0.89A 4nkvD-4g2bA:
undetectable		 4nkvD-4g2bA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSA

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		4 GLY A 266
ASP A 265
GLU A 244
VAL A 113
 None
 0.84A 4nkvD-4hdsA:
undetectable		 4nkvD-4hdsA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4b PYLD

(Methanosarcina
barkeri) 		no annotation 4 TYR A  39
GLY A 250
GLU A 131
VAL A  26
 None
MG  A 903 (-4.0A)
None
None
 1.01A 4nkvD-4j4bA:
undetectable		 4nkvD-4j4bA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjj CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Thermobifida
fusca) 		PF02011
(Glyco_hydro_48) 		4 GLY A 517
ASP A 518
GLU A 526
VAL A 454
 None
None
ZN  A 718 ( 2.0A)
None
 1.16A 4nkvD-4jjjA:
undetectable		 4nkvD-4jjjA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1

(Arabidopsis
thaliana) 		PF01399
(PCI)
PF10602
(RPN7) 		4 TYR A 168
GLY A 141
ASP A 144
VAL A 185
 None
 1.11A 4nkvD-4lctA:
undetectable		 4nkvD-4lctA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5f PUTATIVE ACYL-COA
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 TYR A  66
GLY A 245
GLU A 240
VAL A 372
 None
 1.11A 4nkvD-4n5fA:
undetectable		 4nkvD-4n5fA:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		5 TYR A 201
GLY A 297
ASP A 298
GLU A 305
VAL A 366
 None
None
3QZ  A 601 (-3.5A)
3QZ  A 601 ( 4.9A)
HEM  A 600 ( 3.4A)
 0.25A 4nkvD-4nkyA:
61.4		 4nkvD-4nkyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on3 SORTING NEXIN-10

(Homo sapiens) 		PF00787
(PX) 		4 TYR A  32
GLY A  97
ASP A 100
VAL A  11
 None
 1.14A 4nkvD-4on3A:
undetectable		 4nkvD-4on3A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkh GELSOLIN,TROPOMODULI
N-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin)
PF03250
(Tropomodulin) 		4 GLY B 175
ASP B 123
GLU B  74
VAL B  96
 None
 0.92A 4nkvD-4pkhB:
undetectable		 4nkvD-4pkhB:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin) 		4 GLY G 175
ASP G 123
GLU G  74
VAL G  96
 None
 0.90A 4nkvD-4pkiG:
undetectable		 4nkvD-4pkiG:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pt2 ENCAPSULIN PROTEIN

(Myxococcus
xanthus) 		no annotation 4 TYR P  53
GLY P 137
ASP P 133
VAL P 228
 None
 1.11A 4nkvD-4pt2P:
undetectable		 4nkvD-4pt2P:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		5 TYR A 214
GLY A 308
ASP A 309
GLU A 316
VAL A 377
 AER  A 601 (-4.7A)
None
AER  A 601 ( 4.1A)
None
HEM  A 600 (-4.6A)
 0.73A 4nkvD-4r1zA:
51.7		 4nkvD-4r1zA:
46.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ri2 PHOTOSYSTEM II 22
KDA PROTEIN,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00504
(Chloroa_b-bind) 		4 GLY A  97
ASP A  98
GLU A  35
VAL A 103
 None
None
BNG  A 301 ( 4.4A)
None
 1.15A 4nkvD-4ri2A:
undetectable		 4nkvD-4ri2A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wx3 HEMOLYSIN, HEAT
LABILE

(Grimontia
hollisae) 		PF03347
(TDH) 		4 TYR A 140
GLY A 145
ASP A  14
VAL A 110
 None
 1.08A 4nkvD-4wx3A:
undetectable		 4nkvD-4wx3A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin) 		4 GLY G 124
ASP G  72
GLU G  23
VAL G  45
 None
 0.95A 4nkvD-4z94G:
undetectable		 4nkvD-4z94G:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Homo sapiens) 		PF01966
(HD) 		4 GLY A 124
ASP A 120
GLU A 127
VAL A 133
 None
 0.87A 4nkvD-4zweA:
undetectable		 4nkvD-4zweA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Homo sapiens) 		PF01966
(HD) 		4 GLY A 124
ASP A 120
GLU A 127
VAL A 133
 None
 0.89A 4nkvD-5ao0A:
undetectable		 4nkvD-5ao0A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 GLY A 654
ASP A 481
GLU A 467
VAL A 438
 None
 1.13A 4nkvD-5btrA:
undetectable		 4nkvD-5btrA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyw TRIOSEPHOSPHATE
ISOMERASE

(Litopenaeus
vannamei) 		PF00121
(TIM) 		4 GLY A 229
ASP A 228
GLU A 166
VAL A 144
 None
None
PGA  A 301 (-2.6A)
None
 1.16A 4nkvD-5eywA:
undetectable		 4nkvD-5eywA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fok IRON TRANSPORT OUTER
MEMBRANE RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 TYR A 325
GLY A 393
ASP A 405
VAL A 203
 None
 1.15A 4nkvD-5fokA:
undetectable		 4nkvD-5fokA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq8 BT_2262
(UNCHARACTERISED
LIPOPROTEIN)

(Bacteroides
thetaiotaomicron) 		PF16403
(DUF5011)
PF16404
(DUF5012) 		4 GLY G 138
ASP G 135
GLU G 120
VAL G  26
 None
 1.15A 4nkvD-5fq8G:
undetectable		 4nkvD-5fq8G:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq8 BT_2262
(UNCHARACTERISED
LIPOPROTEIN)

(Bacteroides
thetaiotaomicron) 		PF16403
(DUF5011)
PF16404
(DUF5012) 		4 GLY G 139
ASP G 135
GLU G 120
VAL G  26
 None
 1.10A 4nkvD-5fq8G:
undetectable		 4nkvD-5fq8G:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijw GLUTAMATE RACEMASE

(Mycolicibacterium
smegmatis) 		PF01177
(Asp_Glu_race) 		4 GLY A  14
ASP A  12
GLU A 243
VAL A  68
 None
DGL  A 301 (-3.3A)
None
None
 1.17A 4nkvD-5ijwA:
undetectable		 4nkvD-5ijwA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 GLY A 496
ASP A 497
GLU A 502
VAL A 155
 None
 0.83A 4nkvD-5ikrA:
undetectable		 4nkvD-5ikrA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL

(Homo sapiens) 		PF01180
(DHO_dh) 		4 GLY A 384
ASP A 388
GLU A  80
VAL A  83
 None
 1.06A 4nkvD-5mvdA:
undetectable		 4nkvD-5mvdA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uro PREDICTED PROTEIN

(Trichoderma
reesei) 		PF00561
(Abhydrolase_1) 		4 TYR A 233
GLY A  45
ASP A 116
VAL A 309
 None
 1.07A 4nkvD-5uroA:
undetectable		 4nkvD-5uroA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrv PROTEIN REGULATED BY
ACID PH

(Agrobacterium
fabrum) 		PF09924
(DUF2156) 		4 GLY A 696
ASP A 695
GLU A 689
VAL A 683
 None
 1.17A 4nkvD-5vrvA:
undetectable		 4nkvD-5vrvA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w76 ANCESTRAL ELOGATION
FACTOR N153

(synthetic
construct) 		no annotation 4 GLY A  84
ASP A  87
GLU A 118
VAL A 126
 None
 0.98A 4nkvD-5w76A:
undetectable		 4nkvD-5w76A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7q CONSENSUS ELONGATION
FACTOR

(synthetic
construct) 		no annotation 4 GLY A  84
ASP A  87
GLU A 118
VAL A 126
 None
 0.98A 4nkvD-5w7qA:
undetectable		 4nkvD-5w7qA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5i HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RCDA

(Escherichia
coli) 		no annotation 4 GLY A  51
ASP A  53
GLU A  58
VAL A 122
 None
 1.12A 4nkvD-5x5iA:
undetectable		 4nkvD-5x5iA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xne -

(-) 		no annotation 4 TYR B  71
GLY B  68
ASP B  50
VAL B  25
 None
 1.05A 4nkvD-5xneB:
undetectable		 4nkvD-5xneB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES6

(Toxoplasma
gondii) 		PF01092
(Ribosomal_S6e) 		4 GLY G  47
ASP G  39
GLU G  44
VAL G  18
 None
 1.10A 4nkvD-5xxuG:
undetectable		 4nkvD-5xxuG:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 TYR A 559
GLY A 569
ASP A 568
GLU A 503
 None
 1.16A 4nkvD-5ze4A:
undetectable		 4nkvD-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eys -

(-) 		no annotation 4 TYR B 352
GLY B 373
ASP B 376
VAL B 427
 None
 0.98A 4nkvD-6eysB:
undetectable		 4nkvD-6eysB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 4 TYR A1481
GLY A1718
GLU A1735
VAL A1763
 None
 1.08A 4nkvD-6fayA:
undetectable		 4nkvD-6fayA:
10.62