SIMILAR PATTERNS OF AMINO ACIDS FOR 4NKV_B_AERB601_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aug | PYROGLUTAMYLPEPTIDASE-1 (Bacillusamyloliquefaciens) |
PF01470(Peptidase_C15) | 5 | LEU A 151ALA A 84ILE A 66ILE A 67GLY A 116 | None | 0.88A | 4nkvB-1augA:undetectable | 4nkvB-1augA:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dm3 | BIOSYNTHETICTHIOLASE ACETYLATEDAT CYS89 (Zoogloearamigera) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | LEU A 300ALA A 386ILE A 307LEU A 310VAL A 313 | None | 0.96A | 4nkvB-1dm3A:undetectable | 4nkvB-1dm3A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iom | CITRATE SYNTHASE (Thermusthermophilus) |
PF00285(Citrate_synt) | 5 | LEU A 203ALA A 193ILE A 125LEU A 124GLY A 343 | None | 0.75A | 4nkvB-1iomA:0.0 | 4nkvB-1iomA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqo | PHOSPHOENOLPYRUVATECARBOXYLASE (Zea mays) |
PF00311(PEPcase) | 5 | LEU A 41ASN A 190ILE A 193LEU A 197VAL A 115 | None | 0.93A | 4nkvB-1jqoA:0.0 | 4nkvB-1jqoA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jx7 | HYPOTHETICAL PROTEINYCHN (Escherichiacoli) |
PF02635(DrsE) | 5 | ALA A 8LEU A 68ALA A 48VAL A 75VAL A 96 | None | 0.98A | 4nkvB-1jx7A:undetectable | 4nkvB-1jx7A:13.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p31 | UDP-N-ACETYLMURAMATE--ALANINE LIGASE (Haemophilusinfluenzae) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | LEU A 225ILE A 121ALA A 298THR A 132VAL A 123 | None | 0.99A | 4nkvB-1p31A:undetectable | 4nkvB-1p31A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pff | METHIONINEGAMMA-LYASE (Trichomonasvaginalis) |
PF01053(Cys_Met_Meta_PP) | 5 | ALA A 243ILE A 202ALA A 91VAL A 222VAL A 204 | None | 0.95A | 4nkvB-1pffA:undetectable | 4nkvB-1pffA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgo | ANAEROBIC COBALAMINBIOSYNTHETIC COBALTCHELATASE (Salmonellaenterica) |
PF06180(CbiK) | 5 | ILE A 84ILE A 85LEU A 114GLY A 144ALA A 173 | NoneSO4 A 400 ( 4.2A)NoneNoneNone | 0.97A | 4nkvB-1qgoA:undetectable | 4nkvB-1qgoA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1su7 | CARBON MONOXIDEDEHYDROGENASE 2 (Carboxydothermushydrogenoformans) |
PF03063(Prismane) | 5 | LEU A 621ILE A 460LEU A 464ALA A 444THR A 474 | None | 0.94A | 4nkvB-1su7A:0.0 | 4nkvB-1su7A:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tlt | PUTATIVEOXIDOREDUCTASE(VIRULENCE FACTORMVIM HOMOLOG) (Escherichiacoli) |
PF01408(GFO_IDH_MocA) | 5 | LEU A 59ALA A 56LEU A 85GLY A 12VAL A 69 | None | 0.97A | 4nkvB-1tltA:undetectable | 4nkvB-1tltA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uy4 | ENDO-1,4-BETA-XYLANASE A ([Clostridium]stercorarium) |
PF03422(CBM_6) | 5 | ALA A 74PHE A 72ILE A 63ALA A 26VAL A 58 | None | 0.94A | 4nkvB-1uy4A:undetectable | 4nkvB-1uy4A:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x0u | HYPOTHETICALMETHYLMALONYL-COADECARBOXYLASE ALPHASUBUNIT (Sulfurisphaeratokodaii) |
PF01039(Carboxyl_trans) | 5 | ALA A 394ILE A 342ILE A 316VAL A 331VAL A 318 | None | 0.90A | 4nkvB-1x0uA:undetectable | 4nkvB-1x0uA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y97 | THREE PRIME REPAIREXONUCLEASE 2 (Homo sapiens) |
no annotation | 5 | ALA A 96ILE A 27LEU A 30GLY A 92ALA A 91 | None | 0.90A | 4nkvB-1y97A:undetectable | 4nkvB-1y97A:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a5h | L-LYSINE2,3-AMINOMUTASE (Clostridiumsubterminale) |
PF04055(Radical_SAM)PF12544(LAM_C) | 5 | ILE A 184ILE A 185LEU A 188VAL A 197VAL A 225 | None | 0.96A | 4nkvB-2a5hA:undetectable | 4nkvB-2a5hA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bku | IMPORTIN BETA-1SUBUNIT (Saccharomycescerevisiae) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 5 | ILE B 416LEU B 417GLY B 436ALA B 439VAL B 409 | None | 0.96A | 4nkvB-2bkuB:undetectable | 4nkvB-2bkuB:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d3l | GLUCAN1,4-ALPHA-MALTOHEXAOSIDASE (Bacillus sp.707) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | ASN A 95ILE A 97ALA A 88VAL A 42VAL A 99 | None | 0.98A | 4nkvB-2d3lA:undetectable | 4nkvB-2d3lA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dph | FORMALDEHYDEDISMUTASE (Pseudomonasputida) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 210ILE A 249ILE A 246LEU A 250VAL A 255 | None | 1.00A | 4nkvB-2dphA:undetectable | 4nkvB-2dphA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gko | SUBTILISINMICROBIAL SERINEPROTEINASES (Bacillussubtilis) |
PF00082(Peptidase_S8) | 5 | ALA A 79ILE A 262GLY A 25ALA A 96VAL A 134 | None | 0.95A | 4nkvB-2gkoA:undetectable | 4nkvB-2gkoA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ipj | ALDO-KETO REDUCTASEFAMILY 1 MEMBER C2 (Homo sapiens) |
PF00248(Aldo_ket_red) | 5 | ALA A 269LEU A 261ALA A 253THR A 251VAL A 283 | NAP A 1 ( 4.8A)NoneNAP A 1 (-3.5A)NoneNone | 0.97A | 4nkvB-2ipjA:undetectable | 4nkvB-2ipjA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jg2 | SERINEPALMITOYLTRANSFERASE (Sphingomonaspaucimobilis) |
PF00155(Aminotran_1_2) | 5 | PHE A 409ILE A 68LEU A 70GLY A 370VAL A 374 | None | 0.96A | 4nkvB-2jg2A:undetectable | 4nkvB-2jg2A:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mgz | PROTEIN ASD-1,ISOFORM A (Caenorhabditiselegans) |
PF00076(RRM_1) | 5 | LEU A 116PHE A 120ILE A 107THR A 162VAL A 171 | NoneNone G C 2 ( 4.8A)NoneNone | 0.94A | 4nkvB-2mgzA:undetectable | 4nkvB-2mgzA:12.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oce | HYPOTHETICAL PROTEINPA5201 (Pseudomonasaeruginosa) |
PF00575(S1)PF09371(Tex_N)PF12836(HHH_3)PF16921(Tex_YqgF) | 5 | LEU A 60ILE A 8LEU A 12ALA A 27VAL A 20 | None | 0.87A | 4nkvB-2oceA:undetectable | 4nkvB-2oceA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oxl | HYPOTHETICAL PROTEINYMGB (Escherichiacoli) |
PF10798(YmgB) | 5 | LEU A 34ASN A 50ILE A 53ILE A 54LEU A 57 | None | 0.58A | 4nkvB-2oxlA:undetectable | 4nkvB-2oxlA:10.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4h | VESTITONE REDUCTASE (Medicago sativa) |
PF01370(Epimerase) | 5 | ILE X 21ILE X 22LEU X 25THR X 35VAL X 32 | None | 0.83A | 4nkvB-2p4hX:undetectable | 4nkvB-2p4hX:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pzd | SERINE PROTEASEHTRA2 (Homo sapiens) |
PF13180(PDZ_2) | 5 | ILE A 413ILE A 393ALA A 405VAL A 364VAL A 396 | None | 0.88A | 4nkvB-2pzdA:undetectable | 4nkvB-2pzdA:12.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r7a | BACTERIAL HEMEBINDING PROTEIN (Shigelladysenteriae) |
PF01497(Peripla_BP_2) | 6 | LEU A 116ILE A 186LEU A 189GLY A 260VAL A 267VAL A 266 | None | 1.05A | 4nkvB-2r7aA:undetectable | 4nkvB-2r7aA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r94 | 2-KETO-3-DEOXY-(6-PHOSPHO-)GLUCONATEALDOLASE (Thermoproteustenax) |
PF00701(DHDPS) | 5 | ASN A 176LEU A 210ALA A 160VAL A 194VAL A 172 | None | 1.00A | 4nkvB-2r94A:undetectable | 4nkvB-2r94A:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v3m | NAF1 (Saccharomycescerevisiae) |
PF04410(Gar1) | 5 | LEU A 208ILE A 151ILE A 153LEU A 143GLY A 179 | None | 0.96A | 4nkvB-2v3mA:undetectable | 4nkvB-2v3mA:13.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wd9 | ACYL-COENZYME ASYNTHETASE ACSM2A,MITOCHONDRIAL (Homo sapiens) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | LEU A 238ILE A 269LEU A 270ALA A 231THR A 221 | None | 0.92A | 4nkvB-2wd9A:undetectable | 4nkvB-2wd9A:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xfb | E2 ENVELOPEGLYCOPROTEIN (Chikungunyavirus) |
PF00943(Alpha_E2_glycop) | 5 | LEU B 175ILE B 101LEU B 98THR B 160VAL B 114 | None | 0.96A | 4nkvB-2xfbB:undetectable | 4nkvB-2xfbB:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xro | HTH-TYPETRANSCRIPTIONALREGULATOR TTGV (Pseudomonasputida) |
PF01614(IclR)PF09339(HTH_IclR) | 5 | ILE A 53ILE A 54LEU A 57ALA A 26VAL A 63 | None | 0.99A | 4nkvB-2xroA:undetectable | 4nkvB-2xroA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bq9 | PREDICTED ROSSMANNFOLDNUCLEOTIDE-BINDINGDOMAIN-CONTAININGPROTEIN (Idiomarinabaltica) |
PF03641(Lysine_decarbox)PF11892(DUF3412)PF14793(DUF4478) | 5 | ILE A 234ILE A 215GLY A 256ALA A 255VAL A 396 | NoneNoneSO4 A 460 (-3.4A)SO4 A 460 (-4.6A)None | 1.00A | 4nkvB-3bq9A:undetectable | 4nkvB-3bq9A:23.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cax | UNCHARACTERIZEDPROTEIN PF0695 (Pyrococcusfuriosus) |
PF01814(Hemerythrin)PF13596(PAS_10) | 5 | ALA A 146PHE A 236ILE A 214ALA A 244VAL A 169 | None | 0.90A | 4nkvB-3caxA:undetectable | 4nkvB-3caxA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cf4 | ACETYL-COADECARBOXYLASE/SYNTHASE ALPHA SUBUNIT (Methanosarcinabarkeri) |
PF03063(Prismane) | 5 | ILE A 616ILE A 620GLY A 595ALA A 596VAL A 624 | None | 0.95A | 4nkvB-3cf4A:undetectable | 4nkvB-3cf4A:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d7j | UNCHARACTERIZEDPROTEIN SCO6650 (Streptomycescoelicolor) |
PF01242(PTPS) | 5 | ALA A 36LEU A 104GLY A 113VAL A 50VAL A 49 | None | 0.92A | 4nkvB-3d7jA:undetectable | 4nkvB-3d7jA:16.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dcl | TM1086 (Thermotogamaritima) |
PF14505(DUF4438) | 5 | ALA A 274ILE A 84ILE A 152LEU A 156GLY A 239 | None | 0.77A | 4nkvB-3dclA:undetectable | 4nkvB-3dclA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dkn | PREPROTEINTRANSLOCASE SUBUNITSECY (Canis lupus) |
PF00344(SecY) | 6 | ILE A 389LEU A 386GLY A 394ALA A 395THR A 216VAL A 223 | None | 1.41A | 4nkvB-3dknA:undetectable | 4nkvB-3dknA:22.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3e4e | CYTOCHROME P450 2E1 (Homo sapiens) |
PF00067(p450) | 5 | LEU A 133ILE A 183LEU A 265GLY A 300ALA A 299 | NoneNoneNoneHEM A 500 (-3.4A)HEM A 500 ( 3.3A) | 0.72A | 4nkvB-3e4eA:43.3 | 4nkvB-3e4eA:31.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hhg | TRANSCRIPTIONALREGULATOR, LYSRFAMILY (Neisseriameningitidis) |
PF00126(HTH_1)PF03466(LysR_substrate) | 5 | LEU A 173ILE A 254ILE A 167LEU A 256VAL A 237 | None | 0.95A | 4nkvB-3hhgA:undetectable | 4nkvB-3hhgA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hno | PYROPHOSPHATE-DEPENDENTPHOSPHOFRUCTOKINASE (Nitrosospiramultiformis) |
PF00365(PFK) | 5 | LEU A 405ALA A 41PHE A 76LEU A 68GLY A 58 | None | 0.91A | 4nkvB-3hnoA:undetectable | 4nkvB-3hnoA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrd | NICOTINATEDEHYDROGENASEFAD-SUBUNIT (Eubacteriumbarkeri) |
PF00941(FAD_binding_5)PF03450(CO_deh_flav_C) | 5 | LEU C 163LEU C 137GLY C 113VAL C 135VAL C 172 | FAD C 900 ( 4.7A)NoneFAD C 900 (-3.3A)NoneNone | 0.74A | 4nkvB-3hrdC:undetectable | 4nkvB-3hrdC:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ils | AFLATOXINBIOSYNTHESISPOLYKETIDE SYNTHASE (Aspergillusparasiticus) |
PF00975(Thioesterase) | 5 | LEU A1868ALA A1943ILE A2104ILE A2100GLY A2034 | None | 0.93A | 4nkvB-3ilsA:undetectable | 4nkvB-3ilsA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j81 | US5 (Kluyveromyceslactis) |
PF00333(Ribosomal_S5)PF03719(Ribosomal_S5_C) | 5 | ILE C 135ILE C 134GLY C 128VAL C 107VAL C 85 | NoneNoneNoneNone C 3 24 ( 4.0A) | 0.89A | 4nkvB-3j81C:undetectable | 4nkvB-3j81C:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k1j | ATP-DEPENDENTPROTEASE LON (Thermococcusonnurineus) |
PF01078(Mg_chelatase)PF05362(Lon_C)PF13654(AAA_32) | 5 | PHE A 512ILE A 474ALA A 531VAL A 488VAL A 491 | None | 0.97A | 4nkvB-3k1jA:undetectable | 4nkvB-3k1jA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k6g | TELOMERICREPEAT-BINDINGFACTOR 2-INTERACTINGPROTEIN 1 (Homo sapiens) |
PF11626(Rap1_C) | 5 | ILE A 317ILE A 318LEU A 321GLY A 341VAL A 332 | None | 0.97A | 4nkvB-3k6gA:undetectable | 4nkvB-3k6gA:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kq5 | HYPOTHETICALCYTOSOLIC PROTEIN (Coxiellaburnetii) |
PF07515(TraI_2_C) | 5 | LEU A 260ILE A 292LEU A 287VAL A 285VAL A 280 | None | 0.99A | 4nkvB-3kq5A:undetectable | 4nkvB-3kq5A:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l2z | BIRA BIFUNCTIONALPROTEIN (Mycobacteriumtuberculosis) |
PF02237(BPL_C)PF03099(BPL_LplA_LipB) | 5 | LEU A 190ALA A 105ILE A 82ILE A 83LEU A 84 | None | 0.85A | 4nkvB-3l2zA:undetectable | 4nkvB-3l2zA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lke | ENOYL-COA HYDRATASE (Bacillushalodurans) |
PF00378(ECH_1) | 5 | LEU A 19ALA A 106LEU A 36GLY A 116VAL A 94 | None | 0.86A | 4nkvB-3lkeA:undetectable | 4nkvB-3lkeA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mae | 2-OXOISOVALERATEDEHYDROGENASE E2COMPONENT,DIHYDROLIPOAMIDEACETYLTRANSFERASE (Listeriamonocytogenes) |
PF00198(2-oxoacid_dh) | 5 | PHE A 397ILE A 277ILE A 279ALA A 251VAL A 333 | None | 0.99A | 4nkvB-3maeA:undetectable | 4nkvB-3maeA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n40 | P62 ENVELOPEGLYCOPROTEIN (Chikungunyavirus) |
PF00943(Alpha_E2_glycop)PF01563(Alpha_E3_glycop) | 5 | LEU P 175ILE P 101LEU P 98THR P 160VAL P 114 | NoneNoneNoneACT P 2 (-3.4A)None | 0.98A | 4nkvB-3n40P:undetectable | 4nkvB-3n40P:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pm0 | CYTOCHROME P450 1B1 (Homo sapiens) |
PF00067(p450) | 5 | ALA A 133PHE A 134GLY A 329ALA A 330THR A 334 | HEM A 900 (-3.3A)BHF A 800 (-4.8A)BHF A 800 ( 4.0A)HEM A 900 ( 3.4A)HEM A 900 ( 3.2A) | 0.47A | 4nkvB-3pm0A:41.0 | 4nkvB-3pm0A:29.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pmc | UNCHARACTERIZEDPROTEINPXO2-61/BXB0075/GBAA_PXO2_0075 (Bacillusanthracis) |
PF09385(HisK_N) | 5 | PHE A 50ASN A 97ILE A 98LEU A 8VAL A 113 | None | 1.00A | 4nkvB-3pmcA:undetectable | 4nkvB-3pmcA:17.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqg | METHYL-COENZYME MREDUCTASE, BETASUBUNIT (unculturedarchaeon) |
PF02241(MCR_beta)PF02783(MCR_beta_N) | 5 | ALA B 267ASN B 326ILE B 327GLY B 309ALA B 308 | None | 0.93A | 4nkvB-3sqgB:undetectable | 4nkvB-3sqgB:24.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sv0 | CASEIN KINASE I-LIKE (Oryza sativa) |
PF00069(Pkinase) | 5 | ASN A 133ILE A 148ILE A 147ALA A 153VAL A 119 | None | 0.99A | 4nkvB-3sv0A:undetectable | 4nkvB-3sv0A:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t32 | AMINOTRANSFERASE,CLASS I/II (Bacillusanthracis) |
PF00155(Aminotran_1_2) | 5 | LEU A 378ALA A 298ILE A 344ILE A 27VAL A 370 | None | 0.79A | 4nkvB-3t32A:undetectable | 4nkvB-3t32A:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t8q | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Hoefleaphototrophica) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 62ALA A 48LEU A 89GLY A 53VAL A 19 | None | 0.97A | 4nkvB-3t8qA:undetectable | 4nkvB-3t8qA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tbh | O-ACETYL SERINESULFHYDRYLASE (Leishmaniadonovani) |
PF00291(PALP) | 5 | ILE A 231GLY A 253ALA A 252THR A 213VAL A 210 | None | 0.83A | 4nkvB-3tbhA:undetectable | 4nkvB-3tbhA:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3txo | PROTEIN KINASE C ETATYPE (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 5 | LEU A 480ILE A 463ILE A 464LEU A 467GLY A 541 | None | 0.92A | 4nkvB-3txoA:undetectable | 4nkvB-3txoA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ue3 | SEPTUM FORMATION,PENICILLIN BINDINGPROTEIN 3,PEPTIDOGLYCANSYNTHETASE (Acinetobactersp. ATCC 27244) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 5 | LEU A 477ASN A 202ILE A 205ILE A 206LEU A 219 | None | 0.88A | 4nkvB-3ue3A:undetectable | 4nkvB-3ue3A:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vov | GLUCOKINASE (Thermusthermophilus) |
PF00480(ROK) | 6 | LEU A 43LEU A 94GLY A 64ALA A 289THR A 292VAL A 102 | None | 1.27A | 4nkvB-3vovA:undetectable | 4nkvB-3vovA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c0r | PUTATIVE AMINO ACIDBINDING PROTEIN (Streptococcusmutans) |
PF00497(SBP_bac_3) | 5 | LEU A 145ILE A 170ILE A 171VAL A 94VAL A 181 | GDS A 500 ( 3.3A)NoneNoneNoneNone | 0.93A | 4nkvB-4c0rA:undetectable | 4nkvB-4c0rA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dun | PUTATIVE PHENAZINEBIOSYNTHESISPHZC/PHZF PROTEIN (Clostridioidesdifficile) |
PF02567(PhzC-PhzF) | 5 | LEU A 167ILE A 173LEU A 144GLY A 132VAL A 138 | None | 0.94A | 4nkvB-4dunA:undetectable | 4nkvB-4dunA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g09 | HISTIDINOLDEHYDROGENASE (Brucella suis) |
PF00815(Histidinol_dh) | 5 | LEU A 61LEU A 50GLY A 188ALA A 192VAL A 41 | None | 0.96A | 4nkvB-4g09A:undetectable | 4nkvB-4g09A:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hqe | TRANSCRIPTIONALREGULATOR QSRR (Staphylococcusaureus) |
PF01638(HxlR) | 5 | ASN A 20ILE A 23ILE A 24LEU A 27ALA A 60 | None | 0.83A | 4nkvB-4hqeA:undetectable | 4nkvB-4hqeA:12.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jb6 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Pseudomonasaeruginosa) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | LEU A 232ALA A 208PHE A 230ILE A 109LEU A 343 | None | 0.99A | 4nkvB-4jb6A:undetectable | 4nkvB-4jb6A:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jlv | C-TERMINAL FRAGMENTOF MEMBRANE PROTEINCAPA1, PUTATIVEUNCHARACTERIZEDPROTEIN CAPB1 (Staphylococcusaureus) |
PF13614(AAA_31) | 5 | LEU A1044ILE A1032ILE A1028GLY A1207VAL A1058 | None | 0.86A | 4nkvB-4jlvA:undetectable | 4nkvB-4jlvA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jm0 | PROTEIN UL141 (Humanbetaherpesvirus5) |
PF16758(UL141) | 5 | ILE A 65LEU A 129GLY A 139ALA A 138VAL A 63 | None | 0.90A | 4nkvB-4jm0A:undetectable | 4nkvB-4jm0A:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jrm | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Vibrio cholerae) |
no annotation | 5 | LEU D 232ALA D 208PHE D 230ILE D 109LEU D 344 | None | 0.95A | 4nkvB-4jrmD:undetectable | 4nkvB-4jrmD:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jrm | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Vibrio cholerae) |
no annotation | 5 | LEU D 232PHE D 230ILE D 109LEU D 344GLY D 202 | None | 0.95A | 4nkvB-4jrmD:undetectable | 4nkvB-4jrmD:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kp2 | HOMOACONITASE LARGESUBUNIT (Methanocaldococcusjannaschii) |
PF00330(Aconitase) | 5 | ALA A 184GLY A 219ALA A 211VAL A 175VAL A 172 | None | 0.98A | 4nkvB-4kp2A:undetectable | 4nkvB-4kp2A:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n40 | PROTEIN ECT2 (Homo sapiens) |
PF00533(BRCT)PF12738(PTCB-BRCT) | 5 | LEU A 55ILE A 66LEU A 65GLY A 75VAL A 123 | None | 0.84A | 4nkvB-4n40A:undetectable | 4nkvB-4n40A:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n78 | CYTOPLASMICFMR1-INTERACTINGPROTEIN 1 (Homo sapiens) |
PF05994(FragX_IP)PF07159(DUF1394) | 5 | ASN A1215ILE A1218ILE A1219LEU A1222VAL A1166 | None | 0.76A | 4nkvB-4n78A:undetectable | 4nkvB-4n78A:18.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nky | STEROID17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) |
PF00067(p450) | 12 | LEU A 105ALA A 113PHE A 114ASN A 202ILE A 205ILE A 206LEU A 209GLY A 301ALA A 302THR A 306VAL A 482VAL A 483 | 3QZ A 601 ( 4.2A)HEM A 600 ( 2.9A)3QZ A 601 ( 4.1A)3QZ A 601 (-3.5A)3QZ A 601 ( 3.4A)3QZ A 601 ( 4.6A)3QZ A 601 ( 4.8A)3QZ A 601 ( 3.0A)3QZ A 601 (-2.9A)HEM A 600 ( 3.2A)3QZ A 601 (-4.1A)3QZ A 601 (-4.1A) | 0.28A | 4nkvB-4nkyA:63.3 | 4nkvB-4nkyA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q16 | NH(3)-DEPENDENTNAD(+) SYNTHETASE (Deinococcusradiodurans) |
PF02540(NAD_synthase) | 5 | LEU A 173ILE A 15ILE A 16ALA A 242VAL A 21 | None | 0.84A | 4nkvB-4q16A:undetectable | 4nkvB-4q16A:19.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r1z | CYP17A1 PROTEIN (Danio rerio) |
PF00067(p450) | 8 | LEU A 118ALA A 126ILE A 218GLY A 312ALA A 313THR A 317VAL A 493VAL A 494 | NoneHEM A 600 (-3.6A)AER A 601 ( 4.3A)AER A 601 ( 3.7A)HEM A 600 (-3.5A)HEM A 600 ( 3.3A)NoneNone | 0.53A | 4nkvB-4r1zA:51.1 | 4nkvB-4r1zA:46.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r1z | CYP17A1 PROTEIN (Danio rerio) |
PF00067(p450) | 8 | LEU A 118ALA A 126PHE A 127ILE A 218GLY A 312ALA A 313THR A 317VAL A 494 | NoneHEM A 600 (-3.6A)NoneAER A 601 ( 4.3A)AER A 601 ( 3.7A)HEM A 600 (-3.5A)HEM A 600 ( 3.3A)None | 0.53A | 4nkvB-4r1zA:51.1 | 4nkvB-4r1zA:46.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r20 | CYTOCHROME P450FAMILY 17POLYPEPTIDE 2 (Danio rerio) |
PF00067(p450) | 8 | ALA A 120PHE A 121ASN A 209ILE A 212GLY A 301ALA A 302THR A 306VAL A 481 | AER A 602 (-3.7A)NoneAER A 602 (-4.5A)AER A 602 (-3.2A)AER A 602 ( 3.8A)HEM A 601 (-3.4A)HEM A 601 ( 3.3A)None | 0.66A | 4nkvB-4r20A:49.6 | 4nkvB-4r20A:44.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r20 | CYTOCHROME P450FAMILY 17POLYPEPTIDE 2 (Danio rerio) |
PF00067(p450) | 6 | ASN A 209ILE A 212ALA A 302THR A 306VAL A 480VAL A 481 | AER A 602 (-4.5A)AER A 602 (-3.2A)HEM A 601 (-3.4A)HEM A 601 ( 3.3A)AER A 602 ( 4.9A)None | 0.72A | 4nkvB-4r20A:49.6 | 4nkvB-4r20A:44.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r20 | CYTOCHROME P450FAMILY 17POLYPEPTIDE 2 (Danio rerio) |
PF00067(p450) | 6 | LEU A 112ASN A 209ILE A 212THR A 306VAL A 480VAL A 481 | AER A 602 ( 4.8A)AER A 602 (-4.5A)AER A 602 (-3.2A)HEM A 601 ( 3.3A)AER A 602 ( 4.9A)None | 0.94A | 4nkvB-4r20A:49.6 | 4nkvB-4r20A:44.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r20 | CYTOCHROME P450FAMILY 17POLYPEPTIDE 2 (Danio rerio) |
PF00067(p450) | 7 | LEU A 112PHE A 121ASN A 209ILE A 212GLY A 301THR A 306VAL A 481 | AER A 602 ( 4.8A)NoneAER A 602 (-4.5A)AER A 602 (-3.2A)AER A 602 ( 3.8A)HEM A 601 ( 3.3A)None | 0.85A | 4nkvB-4r20A:49.6 | 4nkvB-4r20A:44.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uzs | BETA-GALACTOSIDASE (Bifidobacteriumbifidum) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 5 | ILE A 77LEU A 80GLY A 54ALA A 90VAL A 153 | POL A 706 ( 4.1A)NoneNoneNoneNone | 0.88A | 4nkvB-4uzsA:undetectable | 4nkvB-4uzsA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xz7 | PUTATIVEUNCHARACTERIZEDPROTEIN (Streptococcussuis) |
PF01841(Transglut_core) | 5 | ALA A 300ILE A 236LEU A 239VAL A 262VAL A 259 | None | 0.84A | 4nkvB-4xz7A:undetectable | 4nkvB-4xz7A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxi | TYROCIDINESYNTHETASE 3 (Acinetobacterbaumannii) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF13193(AMP-binding_C) | 5 | LEU A 607ALA A 518ILE A 489ILE A 485LEU A 486 | None | 1.00A | 4nkvB-4zxiA:undetectable | 4nkvB-4zxiA:17.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ay7 | XYLANASE (Aegilopsspeltoides) |
PF00331(Glyco_hydro_10) | 5 | LEU A 241ILE A 291LEU A 284ALA A 228VAL A 283 | None | 0.99A | 4nkvB-5ay7A:undetectable | 4nkvB-5ay7A:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b0u | OPLOPHORUS-LUCIFERIN2-MONOOXYGENASECATALYTIC SUBUNIT (Oplophorusgracilirostris) |
no annotation | 5 | LEU A 30ILE A 76GLY A 71VAL A 90VAL A 80 | None | 0.93A | 4nkvB-5b0uA:undetectable | 4nkvB-5b0uA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c3u | L-SERINEAMMONIA-LYASE (Rhizomucormiehei) |
PF00291(PALP) | 5 | ASN A 186ILE A 189GLY A 182VAL A 202VAL A 253 | NoneNonePLP A 401 (-3.4A)NoneNone | 1.00A | 4nkvB-5c3uA:undetectable | 4nkvB-5c3uA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cca | ENDORIBONUCLEASEMAZF3 (Mycobacteriumtuberculosis) |
PF02452(PemK_toxin) | 5 | ILE A 68LEU A 73ALA A 33THR A 65VAL A 30 | None | 0.95A | 4nkvB-5ccaA:undetectable | 4nkvB-5ccaA:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d9t | DEHYDROASCORBATEREDUCTASE (Oryza sativa) |
PF13410(GST_C_2)PF13417(GST_N_3) | 5 | LEU A 30ILE A 81ILE A 77GLY A 65VAL A 62 | None | 0.98A | 4nkvB-5d9tA:undetectable | 4nkvB-5d9tA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ftf | TPR DOMAIN PROTEIN (Bacteroides sp.3_1_23) |
PF05970(PIF1) | 5 | ILE A 118ILE A 114LEU A 115ALA A 53THR A 55 | None | 0.97A | 4nkvB-5ftfA:undetectable | 4nkvB-5ftfA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fvd | NUCLEOCAPSID (Humanmetapneumovirus) |
PF03246(Pneumo_ncap) | 5 | LEU A 223ILE A 82LEU A 83GLY A 75VAL A 92 | None | 0.87A | 4nkvB-5fvdA:undetectable | 4nkvB-5fvdA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6q | CELL WALL BINDINGPROTEIN CWP8 (Clostridioidesdifficile) |
PF04122(CW_binding_2) | 5 | LEU A 280ILE A 251LEU A 223GLY A 210VAL A 217 | None | 0.83A | 4nkvB-5j6qA:undetectable | 4nkvB-5j6qA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ux5 | BIFUNCTIONAL PROTEINPROLINE UTILIZATIONA (PUTA) (Corynebacteriumfreiburgense) |
PF00171(Aldedh)PF01619(Pro_dh) | 5 | ASN A 531ILE A 532LEU A 536ALA A 526VAL A 555 | None | 0.92A | 4nkvB-5ux5A:undetectable | 4nkvB-5ux5A:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xct | VH(S112C)-SARAHCHIMERA (Homo sapiens;Mus musculus) |
PF07686(V-set)PF11629(Mst1_SARAH) | 5 | ALA A 60ASN A 82ILE A 82LEU A 80GLY A 65 | None | 0.92A | 4nkvB-5xctA:undetectable | 4nkvB-5xctA:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b82 | CYTOCHROME P450,FAMILY 17, SUBFAMILYA, POLYPEPTIDE 1 (Danio rerio) |
no annotation | 9 | LEU A 118ALA A 126PHE A 127ILE A 218GLY A 312ALA A 313THR A 317VAL A 493VAL A 494 | NoneHEM A 601 (-3.8A)NoneAER A 602 (-3.9A)AER A 602 ( 3.7A)HEM A 601 (-3.6A)HEM A 601 ( 3.7A)AER A 602 ( 4.7A)None | 0.51A | 4nkvB-6b82A:49.2 | 4nkvB-6b82A:9.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cau | UDP-N-ACETYLMURAMATE--L-ALANINE LIGASE (Acinetobacterbaumannii) |
no annotation | 5 | LEU A 229ILE A 125ALA A 302THR A 136VAL A 127 | None | 0.98A | 4nkvB-6cauA:undetectable | 4nkvB-6cauA:8.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cer | PYRUVATEDEHYDROGENASE E1COMPONENT SUBUNITALPHA, SOMATIC FORM,MITOCHONDRIAL (Homo sapiens) |
no annotation | 5 | LEU A 231ALA A 5PHE A 7ILE A 230GLY A 32 | None | 0.93A | 4nkvB-6cerA:undetectable | 4nkvB-6cerA:8.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfd | ATP-DEPENDENT CLPPROTEASE PROTEOLYTICSUBUNIT (Enterococcusfaecium) |
no annotation | 5 | ALA A 106ILE A 44ILE A 45LEU A 48GLY A 74 | None | 0.68A | 4nkvB-6cfdA:undetectable | 4nkvB-6cfdA:11.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ct0 | DIHYDROLIPOYLLYSINE-RESIDUEACETYLTRANSFERASECOMPONENT OFPYRUVATEDEHYDROGENASECOMPLEX,MITOCHONDRIAL (Homo sapiens) |
no annotation | 5 | ASN 0 477ILE 0 480ILE 0 481ALA 0 514VAL 0 511 | None | 0.93A | 4nkvB-6ct00:undetectable | 4nkvB-6ct00:8.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ems | TRNA(GUANINE(9)-/ADENINE(9)-N1)-METHYLTRANSFERASE (Thermococcuskodakarensis) |
no annotation | 5 | LEU A 130ALA A 140ILE A 254LEU A 251ALA A 198 | None | 0.79A | 4nkvB-6emsA:undetectable | 4nkvB-6emsA:9.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f2u | ALDO-KETO REDUCTASEFAMILY 1 MEMBER C3 (Homo sapiens) |
no annotation | 5 | ALA A 269LEU A 261ALA A 253THR A 251VAL A 283 | NAP A 401 ( 4.7A)NoneNAP A 401 (-3.4A)NoneNone | 0.98A | 4nkvB-6f2uA:undetectable | 4nkvB-6f2uA:10.79 |