SIMILAR PATTERNS OF AMINO ACIDS FOR 4NJV_D_RITD500
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bqc | PROTEIN(BETA-MANNANASE) (Thermobifidafusca) |
PF00150(Cellulase) | 5 | GLY A 227ILE A 195GLY A 224ILE A 252ILE A 240 | None | 0.84A | 4njvC-1bqcA:0.0 | 4njvC-1bqcA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c4o | DNA NUCLEOTIDEEXCISION REPAIRENZYME UVRB (Thermusthermophilus) |
PF00271(Helicase_C)PF04851(ResIII)PF12344(UvrB) | 5 | GLY A 534ILE A 406GLY A 36PRO A 409THR A 410 | None | 1.01A | 4njvC-1c4oA:0.0 | 4njvC-1c4oA:9.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1czi | CHYMOSIN (Bos taurus) |
PF00026(Asp) | 5 | ASP E 215GLY E 217VAL E 222GLY E 76ILE E 300 | None | 0.72A | 4njvC-1cziE:6.6 | 4njvC-1cziE:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g0v | PROTEASE A INHIBITOR3PROTEINASE A (Saccharomycescerevisiae) |
PF00026(Asp)PF10466(Inhibitor_I34) | 5 | ASP A 32GLY A 34ILE A 73GLY B 21ILE A 120 | None | 0.96A | 4njvC-1g0vA:7.3 | 4njvC-1g0vA:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hp1 | 5'-NUCLEOTIDASE (Escherichiacoli) |
PF00149(Metallophos)PF02872(5_nucleotid_C) | 5 | ASP A 486VAL A 443ILE A 480THR A 448ILE A 444 | None | 0.98A | 4njvC-1hp1A:undetectable | 4njvC-1hp1A:12.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | ARG A 8ASP A 25GLY A 27ASP A 29VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | A79 A 800 (-3.4A)A79 A 800 (-2.7A)A79 A 800 (-3.0A)A79 A 800 (-2.8A)A79 A 800 ( 4.4A)A79 A 800 ( 3.2A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-3.6A) | 0.49A | 4njvC-1hvcA:17.9 | 4njvC-1hvcA:43.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | ARG A 8ASP A 25GLY A 27ASP A 29VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | A79 A 800 (-3.6A)A79 A 800 (-2.8A)A79 A 800 (-3.0A)A79 A 800 (-2.7A)A79 A 800 ( 4.3A)A79 A 800 ( 3.4A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A)A79 A 800 (-3.8A) | 0.30A | 4njvC-1hvcA:17.9 | 4njvC-1hvcA:43.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ir0 | FERREDOXIN (Bacillusthermoproteolyticus) |
PF13370(Fer4_13) | 5 | GLY A 60VAL A 6GLY A 18THR A 4ILE A 66 | NoneSF4 A 82 ( 4.6A)NoneNoneSF4 A 82 (-4.8A) | 0.95A | 4njvC-1ir0A:undetectable | 4njvC-1ir0A:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mld | MALATE DEHYDROGENASE (Sus scrofa) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | GLY A 7VAL A 97ILE A 115THR A 92ILE A 96 | None | 0.96A | 4njvC-1mldA:undetectable | 4njvC-1mldA:15.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nvm | ACETALDEHYDEDEHYDROGENASE(ACYLATING) (Pseudomonas sp.CF600) |
PF01118(Semialdhyde_dh)PF09290(AcetDehyd-dimer) | 5 | GLY B 192VAL B 211GLY B 187ILE B 186ILE B 155 | None | 1.00A | 4njvC-1nvmB:undetectable | 4njvC-1nvmB:16.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oxx | ABC TRANSPORTER, ATPBINDING PROTEIN (Sulfolobussolfataricus) |
PF00005(ABC_tran) | 5 | GLY K 249VAL K 265ILE K 347GLY K 275ILE K 235 | NoneNoneNoneNoneIOD K1921 (-4.4A) | 0.95A | 4njvC-1oxxK:undetectable | 4njvC-1oxxK:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pix | GLUTACONYL-COADECARBOXYLASE ASUBUNIT (Acidaminococcusfermentans) |
PF01039(Carboxyl_trans) | 6 | GLY A 277VAL A 143GLY A 283PRO A 182THR A 203ILE A 184 | None | 1.48A | 4njvC-1pixA:undetectable | 4njvC-1pixA:11.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 6 | ASP A 25GLY A 27ASP A 29VAL A 32PRO A 81ILE A 84 | None | 0.86A | 4njvC-1q9pA:10.4 | 4njvC-1q9pA:84.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 7 | ARG A 8ASP A 25GLY A 27GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.66A | 4njvC-1sivA:18.4 | 4njvC-1sivA:48.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ASP A 29GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.44A | 4njvC-1sivA:18.4 | 4njvC-1sivA:48.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ASP A 25GLY A 27GLY A 48PRO A 81ILE A 84 | None | 0.97A | 4njvC-1sivA:18.4 | 4njvC-1sivA:48.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v9n | MALATE DEHYDROGENASE (Pyrococcushorikoshii) |
PF02615(Ldh_2) | 5 | GLY A 101VAL A 40GLY A 95PRO A 33ILE A 39 | None | 1.00A | 4njvC-1v9nA:undetectable | 4njvC-1v9nA:13.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vq0 | 33 KDA CHAPERONIN (Thermotogamaritima) |
PF01430(HSP33) | 5 | GLY A 111VAL A 73ILE A 70GLY A 106ILE A 64 | None | 0.89A | 4njvC-1vq0A:undetectable | 4njvC-1vq0A:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z9f | SINGLE-STRANDBINDING PROTEIN (Thermotogamaritima) |
PF00436(SSB) | 5 | GLY A 11VAL A 99ILE A 7THR A 57ILE A 55 | None | 0.97A | 4njvC-1z9fA:undetectable | 4njvC-1z9fA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b4q | RHAMNOLIPIDSBIOSYNTHESIS3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Pseudomonasaeruginosa) |
PF13561(adh_short_C2) | 5 | GLY A 237VAL A 90ILE A 25GLY A 28ILE A 88 | None | 0.99A | 4njvC-2b4qA:undetectable | 4njvC-2b4qA:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bgs | ALDOSE REDUCTASE (Hordeum vulgare) |
PF00248(Aldo_ket_red) | 6 | ARG A 252ASP A 14VAL A 272ILE A 270GLY A 28ILE A 257 | NoneNoneNoneNoneNoneNDP A1321 (-4.4A) | 1.33A | 4njvC-2bgsA:undetectable | 4njvC-2bgsA:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0w | GAMMA-GLUTAMYLTRANSPEPTIDASE (Escherichiacoli) |
PF01019(G_glu_transpept) | 5 | ASP A 398GLY A 401VAL A 73ILE A 101THR A 163 | None | 0.97A | 4njvC-2e0wA:undetectable | 4njvC-2e0wA:11.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0x | GAMMA-GLUTAMYLTRANSPEPTIDASE (Escherichiacoli) |
PF01019(G_glu_transpept) | 5 | ASP B 398GLY B 401VAL A 73ILE A 101THR A 163 | None | 0.95A | 4njvC-2e0xB:undetectable | 4njvC-2e0xB:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fj0 | CARBOXYLIC ESTERHYDROLASE (Manduca sexta) |
PF00135(COesterase) | 5 | GLY A 224GLY A 352ILE A 351PRO A 517ILE A 508 | None | 0.96A | 4njvC-2fj0A:undetectable | 4njvC-2fj0A:10.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 9 | ARG A 8ASP A 25GLY A 27ASP A 29VAL A 32ILE A 53GLY A 55PRO A 86ILE A 89 | LP1 A 201 (-3.5A)LP1 A 201 (-2.3A)LP1 A 201 (-3.8A)LP1 A 201 (-3.6A)NoneLP1 A 201 (-4.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 (-4.2A) | 0.54A | 4njvC-2fmbA:15.0 | 4njvC-2fmbA:33.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 5 | ASP A 25GLY A 27VAL A 32GLY A 54ILE A 89 | LP1 A 201 (-2.3A)LP1 A 201 (-3.8A)NoneLP1 A 201 (-3.6A)LP1 A 201 (-4.2A) | 0.76A | 4njvC-2fmbA:15.0 | 4njvC-2fmbA:33.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g3n | ALPHA-GLUCOSIDASE (Sulfolobussolfataricus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 6 | ARG A 154GLY A 115ILE A 102GLY A 66ILE A 65PRO A 528 | None | 1.38A | 4njvC-2g3nA:undetectable | 4njvC-2g3nA:10.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q1y | CELL DIVISIONPROTEIN FTSZ (Mycobacteriumtuberculosis) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | GLY A 224VAL A 128GLY A 193THR A 157ILE A 159 | None | 0.77A | 4njvC-2q1yA:undetectable | 4njvC-2q1yA:14.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q50 | GLYOXYLATEREDUCTASE/HYDROXYPYRUVATE REDUCTASE (Homo sapiens) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | GLY A 72VAL A 63ILE A 78GLY A 54ILE A 67 | None | 0.92A | 4njvC-2q50A:undetectable | 4njvC-2q50A:16.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ARG A 8ASP A 25GLY A 27ASP A 29GLY A 49ILE A 50PRO A 81ILE A 84 | AB1 A 501 ( 4.7A)AB1 A 501 (-2.4A)AB1 A 501 (-3.9A)AB1 A 501 ( 3.3A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.45A | 4njvC-2rkfA:20.6 | 4njvC-2rkfA:80.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vca | ALPHA-N-ACETYLGLUCOSAMINIDASE (Clostridiumperfringens) |
PF00754(F5_F8_type_C)PF05089(NAGLU)PF12971(NAGLU_N)PF12972(NAGLU_C) | 5 | GLY A 32VAL A 152ILE A 132GLY A 130ILE A 29 | None | 0.82A | 4njvC-2vcaA:undetectable | 4njvC-2vcaA:7.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vca | ALPHA-N-ACETYLGLUCOSAMINIDASE (Clostridiumperfringens) |
PF00754(F5_F8_type_C)PF05089(NAGLU)PF12971(NAGLU_N)PF12972(NAGLU_C) | 5 | VAL A 152ILE A 132GLY A 130ILE A 74ILE A 29 | None | 0.91A | 4njvC-2vcaA:undetectable | 4njvC-2vcaA:7.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vxy | CELL DIVISIONPROTEIN FTSZ (Bacillussubtilis) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | GLY A 227VAL A 131GLY A 196THR A 160ILE A 162 | None | 0.87A | 4njvC-2vxyA:undetectable | 4njvC-2vxyA:14.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3er6 | PUTATIVETRANSCRIPTIONALREGULATOR PROTEIN (Vibrioparahaemolyticus) |
PF01965(DJ-1_PfpI) | 5 | GLY A 168ILE A 83GLY A 81ILE A 79ILE A 118 | None | 1.01A | 4njvC-3er6A:undetectable | 4njvC-3er6A:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hn6 | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Borreliellaburgdorferi) |
PF01182(Glucosamine_iso) | 5 | GLY A 139ILE A 193GLY A 136ILE A 202ILE A 226 | None | 0.93A | 4njvC-3hn6A:undetectable | 4njvC-3hn6A:17.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kf3 | INVERTASE (Schwanniomycesoccidentalis) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 5 | ASP A 287GLY A 289ASP A 291ILE A 485PRO A 355 | NoneNoneNoneNoneNAG A5001 ( 4.9A) | 0.95A | 4njvC-3kf3A:undetectable | 4njvC-3kf3A:11.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh9 | THIOL:DISULFIDEINTERCHANGE PROTEINDSBE (Pseudomonasaeruginosa) |
PF08534(Redoxin) | 5 | ASP A 123GLY A 126VAL A 69GLY A 133ILE A 97 | None | 0.93A | 4njvC-3kh9A:undetectable | 4njvC-3kh9A:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lun | ULILYSIN (Methanosarcinaacetivorans) |
PF05572(Peptidase_M43) | 6 | ASP A 207VAL A 71ILE A 87GLY A 211ILE A 93ILE A 173 | None | 1.48A | 4njvC-3lunA:undetectable | 4njvC-3lunA:18.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | ASP A 25GLY A 27ASP A 29VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.46A | 4njvC-3mwsA:19.8 | 4njvC-3mwsA:70.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n71 | HISTONE LYSINEMETHYLTRANSFERASESMYD1 (Mus musculus) |
PF00856(SET)PF01753(zf-MYND) | 5 | ARG A 37GLY A 196VAL A 214GLY A 202ILE A 234 | NoneNoneNoneSFG A 491 (-4.1A)None | 0.96A | 4njvC-3n71A:undetectable | 4njvC-3n71A:14.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3njx | RHAMNOGALACTURONASEB (Aspergillusaculeatus) |
PF09284(RhgB_N)PF14683(CBM-like)PF14686(fn3_3) | 5 | GLY A 346ASP A 349VAL A 336GLY A 420ILE A 419 | None CA A 800 (-2.9A)NoneNoneNone | 0.93A | 4njvC-3njxA:undetectable | 4njvC-3njxA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o04 | BETA-KETO-ACYLCARRIER PROTEINSYNTHASE II (Listeriamonocytogenes) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 102VAL A 238ILE A 171THR A 9ILE A 239 | None | 0.91A | 4njvC-3o04A:undetectable | 4njvC-3o04A:13.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p0s | CAPSID PROTEIN VP (Lepidopteraniteradensovirus1) |
PF01057(Parvo_NS1) | 5 | VAL A 135ILE A 367GLY A 101THR A 390ILE A 388 | None | 0.91A | 4njvC-3p0sA:undetectable | 4njvC-3p0sA:11.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r18 | SULFITE OXIDASE (Gallus gallus) |
PF00174(Oxidored_molyb)PF03404(Mo-co_dimer) | 5 | ARG A 189ASP A 321VAL A 295GLY A 324PRO A 346 | None | 0.89A | 4njvC-3r18A:undetectable | 4njvC-3r18A:10.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ASP A 29VAL A 32ILE A 47GLY A 49ILE A 50 | 017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-3.5A)NoneNone017 A 201 (-4.0A)017 A 201 (-3.3A) | 0.54A | 4njvC-3t3cA:18.4 | 4njvC-3t3cA:74.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | GLY A 27ASP A 29VAL A 32ILE A 47GLY A 49PRO A 81 | 017 A 201 (-3.4A)017 A 201 (-3.5A)NoneNone017 A 201 (-4.0A)None | 0.89A | 4njvC-3t3cA:18.4 | 4njvC-3t3cA:74.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8ASP A 25GLY A 27ASP A 29GLY A 49PRO A 81ILE A 84 | 017 A 201 ( 4.8A)017 A 201 (-2.6A)017 A 201 (-3.6A)017 A 201 (-3.3A)017 A 201 (-3.0A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.60A | 4njvC-3ttpA:19.7 | 4njvC-3ttpA:77.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ASP A 29GLY A 49ILE A 50PRO A 81ILE A 84 | 017 A 201 (-2.6A)017 A 201 (-3.6A)017 A 201 (-3.3A)017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.49A | 4njvC-3ttpA:19.7 | 4njvC-3ttpA:77.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ARG A 8ASP A 25GLY A 27ASP A 29ILE A 47GLY A 49ILE A 50PRO A 81 | None017 A 202 ( 2.5A)017 A 201 ( 3.5A)017 A 201 (-3.2A)017 A 202 (-3.6A)017 A 202 (-2.9A)017 A 201 ( 3.5A)017 A 202 (-4.0A) | 0.69A | 4njvC-3u7sA:20.2 | 4njvC-3u7sA:78.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3uhl | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ARG A 8ASP A 25GLY A 27ASP A 29PRO A 81 | None | 0.78A | 4njvC-3uhlA:16.0 | 4njvC-3uhlA:79.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wbn | PUTATIVEUNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF01554(MatE) | 5 | GLY A 146VAL A 62ILE A 119ILE A 113ILE A 66 | NoneNoneNoneOLC A 503 ( 4.5A)None | 0.96A | 4njvC-3wbnA:undetectable | 4njvC-3wbnA:12.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wgk | CELL DIVISIONPROTEIN FTSZ (Staphylococcusaureus) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | GLY A 225VAL A 131GLY A 196THR A 160ILE A 162 | None | 0.90A | 4njvC-3wgkA:undetectable | 4njvC-3wgkA:11.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ch1 | PROTEIN SUP-12,ISOFORM B (Caenorhabditiselegans) |
PF00076(RRM_1) | 5 | GLY A 41ILE A 37ILE A 67THR A 50ILE A 100 | None | 0.98A | 4njvC-4ch1A:undetectable | 4njvC-4ch1A:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ddw | REVERSE GYRASE (Thermotogamaritima) |
PF00270(DEAD)PF01131(Topoisom_bac)PF01751(Toprim) | 5 | ARG A 725VAL A1026ILE A1007THR A1021ILE A1025 | None | 0.98A | 4njvC-4ddwA:undetectable | 4njvC-4ddwA:7.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4din | CAMP-DEPENDENTPROTEIN KINASE TYPEI-BETA REGULATORYSUBUNIT (Homo sapiens) |
PF00027(cNMP_binding)PF02197(RIIa) | 5 | GLY B 199VAL B 162GLY B 223ILE B 224ILE B 163 | None | 1.00A | 4njvC-4dinB:undetectable | 4njvC-4dinB:12.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e6e | CELL DIVISIONPROTEIN FTSZ (Thermobifidafusca) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | GLY A 224VAL A 128GLY A 193THR A 157ILE A 159 | None | 0.83A | 4njvC-4e6eA:undetectable | 4njvC-4e6eA:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eqv | INVERTASE 2 (Saccharomycescerevisiae) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 5 | ASP A 261GLY A 263ASP A 265ILE A 464PRO A 333 | None | 1.01A | 4njvC-4eqvA:undetectable | 4njvC-4eqvA:11.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gis | ENOLASE (Vibrio harveyi) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ARG A 371GLY A 366ILE A 100THR A 23ILE A 315 | None | 0.97A | 4njvC-4gisA:undetectable | 4njvC-4gisA:13.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hh2 | TRANSCRIPTIONALREGULATOR, PPSR (Rhodobactersphaeroides) |
PF13188(PAS_8)PF13426(PAS_9) | 5 | GLY A 321ASP A 316ILE A 290GLY A 288ILE A 329 | None | 0.92A | 4njvC-4hh2A:undetectable | 4njvC-4hh2A:13.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iv5 | ASPARTATECARBAMOYLTRANSFERASE, PUTATIVE (Trypanosomacruzi) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | GLY A 51VAL A 109ILE A 74PRO A 56THR A 55 | None | 0.93A | 4njvC-4iv5A:undetectable | 4njvC-4iv5A:14.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpn | NUCLEOSIDEN-RIBOHYDROLASE 1 (Physcomitrellapatens) |
PF01156(IU_nuc_hydro) | 5 | GLY A 27ASP A 29GLY A 142ILE A 51ILE A 34 | None CA A 400 ( 4.5A) CA A 400 ( 4.4A)NoneNone | 0.99A | 4njvC-4kpnA:undetectable | 4njvC-4kpnA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpo | NUCLEOSIDEN-RIBOHYDROLASE 3 (Zea mays) |
PF01156(IU_nuc_hydro) | 5 | GLY A 10ASP A 12GLY A 124ILE A 34ILE A 17 | None CA A 401 ( 4.8A) CA A 401 ( 4.3A)NoneNone | 0.91A | 4njvC-4kpoA:undetectable | 4njvC-4kpoA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l0c | DEFORMYLASE (Pseudomonasputida) |
PF12697(Abhydrolase_6) | 5 | GLY A 58ASP A 55ILE A 28GLY A 30ILE A 31 | NoneNoneNoneACY A 301 (-3.6A)None | 0.99A | 4njvC-4l0cA:undetectable | 4njvC-4l0cA:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lur | INTERPHOTORECEPTORRETINOID-BINDINGPROTEIN(IRBP) (Danio rerio) |
PF03572(Peptidase_S41)PF11918(Peptidase_S41_N) | 5 | ILE A 115GLY A 155ILE A 156THR A 148ILE A 111 | None | 0.94A | 4njvC-4lurA:undetectable | 4njvC-4lurA:15.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m75 | U6 SNRNA-ASSOCIATEDSM-LIKE PROTEIN LSM5 (Saccharomycescerevisiae) |
PF01423(LSM) | 5 | GLY E 32ILE E 12GLY E 36ILE E 44ILE E 22 | None | 0.92A | 4njvC-4m75E:undetectable | 4njvC-4m75E:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mdy | PERIPLASMIC BINDINGPROTEIN (Mycolicibacteriumsmegmatis) |
PF01497(Peripla_BP_2) | 5 | VAL A 37GLY A 164ILE A 163THR A 46ILE A 48 | None | 0.87A | 4njvC-4mdyA:undetectable | 4njvC-4mdyA:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qi6 | CELLOBIOSEDEHYDROGENASE (Crassicarponhotsonii) |
PF00732(GMC_oxred_N)PF00734(CBM_1)PF05199(GMC_oxred_C)PF16010(CDH-cyt) | 5 | GLY A 481VAL A 440ILE A 258ILE A 477ILE A 488 | FAD A 902 (-3.6A)FAD A 902 (-4.2A)NoneNoneNone | 0.98A | 4njvC-4qi6A:undetectable | 4njvC-4qi6A:8.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qo5 | HYPOTHETICALMULTIHEME PROTEIN (Ignicoccushospitalis) |
PF13435(Cytochrome_C554)PF13447(Multi-haem_cyto) | 5 | GLY A 225GLY A 230PRO A 135THR A 134ILE A 132 | NoneHEC A 606 ( 3.9A)HEC A 605 ( 4.8A)NoneHEC A 602 ( 4.6A) | 0.94A | 4njvC-4qo5A:undetectable | 4njvC-4qo5A:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rg8 | EXONUCLEASE I (Methylocaldumszegediense) |
PF00929(RNase_T)PF08411(Exonuc_X-T_C) | 6 | GLY A 97ASP A 104ILE A 84GLY A 29ILE A 30THR A 93 | None MG A 501 ( 4.1A)NoneNoneNoneNone | 1.14A | 4njvC-4rg8A:undetectable | 4njvC-4rg8A:12.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqk | LECTIN 2 (Agrocybeaegerita) |
PF13517(VCBS) | 5 | ASP A 345GLY A 350ASP A 290VAL A 343GLY A 371 | None | 0.91A | 4njvC-4tqkA:undetectable | 4njvC-4tqkA:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u39 | CELL DIVISIONPROTEIN FTSZ (Bacillussubtilis) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | GLY A 227VAL A 131GLY A 196THR A 160ILE A 162 | None | 0.93A | 4njvC-4u39A:undetectable | 4njvC-4u39A:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgj | UNCHARACTERIZEDPROTEIN (Pectobacteriumatrosepticum) |
PF07005(DUF1537)PF17042(DUF1357_C) | 5 | ARG A 216GLY A 229VAL A 13GLY A 27ILE A 88 | None | 0.95A | 4njvC-4xgjA:undetectable | 4njvC-4xgjA:11.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 7 | ARG A 10ASP A 32GLY A 34ASP A 36VAL A 39GLY A 58ILE A 100 | None4B1 A 201 (-2.9A)4B1 A 201 ( 4.6A)4B1 A 201 (-4.4A)None4B1 A 201 (-3.4A)4B1 A 201 (-4.8A) | 0.63A | 4njvC-4ydfA:13.2 | 4njvC-4ydfA:33.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yjy | CHALCONE SYNTHASE 1 (Oryza sativa) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 6 | GLY A 375VAL A 274ILE A 257GLY A 379ILE A 249ILE A 278 | None | 1.33A | 4njvC-4yjyA:undetectable | 4njvC-4yjyA:11.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ywl | CELL DIVISIONCONTROL PROTEIN 21 (Pyrococcusfuriosus) |
PF14551(MCM_N)PF17207(MCM_OB) | 5 | GLY A 225VAL A 221ILE A 187GLY A 205ILE A 206 | None | 0.87A | 4njvC-4ywlA:undetectable | 4njvC-4ywlA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ywl | CELL DIVISIONCONTROL PROTEIN 21 (Pyrococcusfuriosus) |
PF14551(MCM_N)PF17207(MCM_OB) | 5 | VAL A 221ILE A 187GLY A 205ILE A 206ILE A 249 | None | 0.94A | 4njvC-4ywlA:undetectable | 4njvC-4ywlA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yzg | PROTEIN PHOSPHATASE2C 57 (Arabidopsisthaliana) |
PF00481(PP2C) | 5 | ASP A 238GLY A 160GLY A 179ILE A 178ILE A 230 | None | 0.99A | 4njvC-4yzgA:undetectable | 4njvC-4yzgA:16.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z38 | MLNA (Bacillusvelezensis) |
no annotation | 5 | GLY A 576GLY A 748ILE A 747PRO A 559ILE A 556 | FMN A 900 (-3.5A)NoneNoneNoneNone | 0.99A | 4njvC-4z38A:undetectable | 4njvC-4z38A:13.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z42 | UREASE SUBUNIT ALPHA (Yersiniaenterocolitica) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 5 | GLY C 172ASP C 365ILE C 140GLY C 162ILE C 143 | None NI C 602 ( 1.9A)NoneNoneNone | 1.00A | 4njvC-4z42C:undetectable | 4njvC-4z42C:9.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8d | CARBOHYDRATE BINDINGFAMILY 6 (Ruminiclostridiumthermocellum) |
PF04616(Glyco_hydro_43) | 5 | GLY A 168VAL A 149ILE A 192ILE A 189ILE A 128 | GOL A1340 (-3.3A)NoneNoneNoneNone | 0.95A | 4njvC-5a8dA:undetectable | 4njvC-5a8dA:14.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b18 | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ARG A 8GLY A 27ASP A 29GLY A 49ILE A 84 | None | 0.92A | 4njvC-5b18A:18.2 | 4njvC-5b18A:78.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d1i | CYCLICNUCLEOTIDE-BINDINGPROTEIN (Brucellaabortus) |
PF00027(cNMP_binding) | 5 | ARG A 40GLY A 96VAL A 76GLY A 83ILE A 60 | None | 0.99A | 4njvC-5d1iA:undetectable | 4njvC-5d1iA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j72 | PUTATIVEN-ACETYLMURAMOYL-L-ALANINEAMIDASE,AUTOLYSINCWP6 (Clostridioidesdifficile) |
PF01520(Amidase_3)PF04122(CW_binding_2) | 5 | ARG A 149GLY A 390VAL A 169ILE A 180ILE A 193 | None | 1.01A | 4njvC-5j72A:undetectable | 4njvC-5j72A:10.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m2s | PUTATIVECELLULOSOMALSCAFFOLDIN PROTEIN (Ruminococcusflavefaciens) |
no annotation | 5 | ASP A 47VAL A 99ILE A 138GLY A 136ILE A 52 | GOL A 203 (-3.7A)NoneNoneNoneNone | 1.01A | 4njvC-5m2sA:undetectable | 4njvC-5m2sA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mif | 'CARBOXYL ESTERASE 2 (Tubermelanosporum) |
PF07859(Abhydrolase_3) | 5 | GLY A 188VAL A 143ILE A 132ILE A 335ILE A 112 | None | 0.99A | 4njvC-5mifA:undetectable | 4njvC-5mifA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ol2 | ELECTRON TRANSFERFLAVOPROTEIN SMALLSUBUNIT (Clostridioidesdifficile) |
no annotation | 6 | GLY B 46VAL B 160ILE B 145ILE B 118THR B 153ILE B 151 | None | 1.10A | 4njvC-5ol2B:undetectable | 4njvC-5ol2B:20.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8ASP A 25ASP A 30GLY A 49ILE A 50ILE A 84 | None | 1.43A | 4njvC-5t2zA:19.8 | 4njvC-5t2zA:85.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | ARG A 8ASP A 25GLY A 27ASP A 29VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.47A | 4njvC-5t2zA:19.8 | 4njvC-5t2zA:85.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t89 | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF00047(ig)PF07679(I-set)PF13927(Ig_3) | 5 | ARG X 261GLY X 316PRO X 257THR X 256ILE X 229 | None | 0.96A | 4njvC-5t89X:undetectable | 4njvC-5t89X:10.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vj7 | OXIDOREDUCTASE (Pyrococcusfuriosus) |
PF07992(Pyr_redox_2)PF14691(Fer4_20) | 5 | GLY A 264ILE A 357GLY A 259ILE A 260PRO A 353 | None | 0.98A | 4njvC-5vj7A:undetectable | 4njvC-5vj7A:12.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | GLY A 225VAL A 287ILE A 277ILE A 304ILE A 286 | NAD A 500 (-3.6A)NoneNoneNAD A 500 (-4.4A)NAD A 500 (-4.8A) | 0.97A | 4njvC-6aphA:undetectable | 4njvC-6aphA:14.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b9h | PROTEIN HOOK HOMOLOG3 (Homo sapiens) |
no annotation | 5 | GLY A 124VAL A 44ILE A 20ILE A 139ILE A 48 | None | 0.79A | 4njvC-6b9hA:undetectable | 4njvC-6b9hA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cqb | CHALCONE SYNTHASE (Pipermethysticum) |
no annotation | 6 | GLY A 373VAL A 272ILE A 255GLY A 377ILE A 247ILE A 276 | None | 1.33A | 4njvC-6cqbA:undetectable | 4njvC-6cqbA:18.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6fiv | RETROPEPSIN (Felineimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ARG A 13ASP A 30GLY A 32ASP A 34GLY A 58 | None3TL A 201 (-3.5A)3TL A 201 (-3.4A)3TL A 201 (-3.9A)3TL A 201 (-3.4A) | 0.27A | 4njvC-6fivA:15.5 | 4njvC-6fivA:31.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 6 | ARG A 8ASP A 25ASP A 30GLY A 49ILE A 50PRO A 81 | NoneNIU A 100 (-2.8A)NoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)None | 1.39A | 4njvC-6upjA:18.5 | 4njvC-6upjA:47.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 7 | ARG A 8ASP A 25GLY A 27ASP A 29GLY A 49ILE A 50PRO A 81 | NoneNIU A 100 (-2.8A)NIU A 100 (-4.5A)NoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)None | 0.93A | 4njvC-6upjA:18.5 | 4njvC-6upjA:47.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 6 | ASP A 25ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | NIU A 100 (-2.8A)NoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)NoneNone | 1.32A | 4njvC-6upjA:18.5 | 4njvC-6upjA:47.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ASP A 29GLY A 49ILE A 50PRO A 81ILE A 84 | NIU A 100 (-2.8A)NIU A 100 (-4.5A)NoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)NoneNone | 0.76A | 4njvC-6upjA:18.5 | 4njvC-6upjA:47.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1azz | COLLAGENASE (Leptucapugilator) |
PF00089(Trypsin) | 5 | ASP A 37GLY A 61ALA A 61ASP A 60ILE A 35 | None | 0.98A | 4njvD-1azzA:undetectable | 4njvD-1azzA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hfe | PROTEIN (FE-ONLYHYDROGENASE(E.C.1.18.99.1)(LARGER SUBUNIT))PROTEIN (FE-ONLYHYDROGENASE(E.C.1.18.99.1)(SMALLER SUBUNIT)) (Desulfovibriovulgaris) |
PF02256(Fe_hyd_SSU)PF02906(Fe_hyd_lg_C)PF13237(Fer4_10) | 5 | ARG L 243GLY L 208ALA L 209GLY L 250THR S 90 | None | 1.05A | 4njvD-1hfeL:undetectable | 4njvD-1hfeL:13.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | ARG A 8ASP A 25GLY A 27ALA A 28ASP A 30VAL A 32ILE A 47GLY A 49ILE A 50ILE A 84 | A79 A 800 (-3.6A)A79 A 800 (-2.8A)A79 A 800 (-3.0A)A79 A 800 (-3.2A)A79 A 800 ( 4.7A)A79 A 800 ( 4.3A)A79 A 800 ( 3.4A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 (-3.8A) | 0.50A | 4njvD-1hvcA:14.0 | 4njvD-1hvcA:43.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 11 | ARG A 8ASP A 25GLY A 27ALA A 28ASP A 30VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | A79 A 800 (-3.4A)A79 A 800 (-2.7A)A79 A 800 (-3.0A)A79 A 800 (-3.1A)A79 A 800 ( 4.9A)A79 A 800 ( 4.4A)A79 A 800 ( 3.2A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-3.6A) | 0.53A | 4njvD-1hvcA:14.0 | 4njvD-1hvcA:43.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | ASP A 25GLY A 27ALA A 28ASP A 30VAL A 32ILE A 47GLY A 49PRO A 81ILE A 84 | A79 A 800 (-2.8A)A79 A 800 (-3.0A)A79 A 800 (-3.2A)A79 A 800 ( 4.7A)A79 A 800 ( 4.3A)A79 A 800 ( 3.4A)A79 A 800 (-3.4A)A79 A 800 ( 3.4A)A79 A 800 (-3.8A) | 0.62A | 4njvD-1hvcA:14.0 | 4njvD-1hvcA:43.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k1d | D-HYDANTOINASE (Geobacillusstearothermophilus) |
PF01979(Amidohydro_1) | 5 | GLY A 32VAL A 50ILE A 5THR A 12ILE A 10 | None | 0.92A | 4njvD-1k1dA:undetectable | 4njvD-1k1dA:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kae | HISTIDINOLDEHYDROGENASE (Escherichiacoli) |
PF00815(Histidinol_dh) | 5 | GLY A 227ALA A 228ASP A 204GLY A 196ILE A 206 | None | 0.87A | 4njvD-1kaeA:undetectable | 4njvD-1kaeA:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcx | DIHYDROPYRIMIDINASERELATED PROTEIN-1 (Mus musculus) |
PF01979(Amidohydro_1) | 5 | GLY A 46ALA A 33VAL A 65ILE A 19ILE A 24 | None | 1.09A | 4njvD-1kcxA:undetectable | 4njvD-1kcxA:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kpl | PUTATIVE CLC FAMILY,CHLORINE TRANSPORTPROTEIN (Salmonellaenterica) |
PF00654(Voltage_CLC) | 5 | GLY A 181ALA A 182ILE A 109PRO A 206ILE A 200 | None | 1.04A | 4njvD-1kplA:undetectable | 4njvD-1kplA:12.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lk5 | D-RIBOSE-5-PHOSPHATEISOMERASE (Pyrococcushorikoshii) |
PF06026(Rib_5-P_isom_A) | 5 | GLY A 101ALA A 102GLY A 207ILE A 97ILE A 179 | CL A1001 (-3.4A)NoneNoneNoneNone | 0.90A | 4njvD-1lk5A:undetectable | 4njvD-1lk5A:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nfg | D-HYDANTOINASE (Ralstoniapickettii) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 5 | GLY A 32VAL A 49ILE A 5THR A 12ILE A 10 | None | 1.03A | 4njvD-1nfgA:undetectable | 4njvD-1nfgA:12.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o4v | PHOSPHORIBOSYLAMINOIMIDAZOLE MUTASE PURE (Thermotogamaritima) |
PF00731(AIRC) | 5 | GLY A 122ALA A 20ILE A 33GLY A 5ILE A 60 | None | 1.05A | 4njvD-1o4vA:undetectable | 4njvD-1o4vA:18.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28ASP A 30VAL A 32PRO A 81ILE A 84 | None | 0.60A | 4njvD-1q9pA:10.9 | 4njvD-1q9pA:84.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28ASP A 30GLY A 49ILE A 50ILE A 84 | None | 0.61A | 4njvD-1sivA:18.3 | 4njvD-1sivA:48.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.51A | 4njvD-1sivA:18.3 | 4njvD-1sivA:48.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tz6 | PUTATIVE SUGARKINASE (Salmonellaenterica) |
PF00294(PfkB) | 5 | ASP A 12GLY A 31ALA A 32THR A 133ILE A 130 | AIS A 402 (-3.6A)AIS A 402 (-3.8A)AIS A 402 ( 4.2A)NoneNone | 1.07A | 4njvD-1tz6A:undetectable | 4njvD-1tz6A:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5f | PYRUVATE OXIDASE (Aerococcusviridans) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ASP A 388ALA A 444ASP A 442VAL A 466ILE A 440 | NoneTPP A1602 (-3.7A) MG A1603 ( 2.8A)NoneNone | 0.84A | 4njvD-1v5fA:undetectable | 4njvD-1v5fA:10.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5f | PYRUVATE OXIDASE (Aerococcusviridans) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLY A 390ASP A 442VAL A 466GLY A 418ILE A 419 | TPP A1602 ( 3.9A) MG A1603 ( 2.8A)NoneNoneNone | 0.94A | 4njvD-1v5fA:undetectable | 4njvD-1v5fA:10.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vdw | HYPOTHETICAL PROTEINPH1897 (Pyrococcushorikoshii) |
PF00459(Inositol_P) | 5 | ALA A 238VAL A 224ILE A 202GLY A 205ILE A 208 | None | 1.11A | 4njvD-1vdwA:undetectable | 4njvD-1vdwA:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xcf | TRYPTOPHAN SYNTHASEALPHA CHAIN (Escherichiacoli) |
PF00290(Trp_syntA) | 5 | GLY A 44ILE A 37PRO A 93THR A 94ILE A 95 | None | 1.01A | 4njvD-1xcfA:undetectable | 4njvD-1xcfA:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yj8 | GLYCEROL-3-PHOSPHATEDEHYDROGENASE (Plasmodiumfalciparum) |
PF01210(NAD_Gly3P_dh_N)PF07479(NAD_Gly3P_dh_C) | 5 | GLY A 143ALA A 224VAL A 329ILE A 228GLY A 322 | None | 1.06A | 4njvD-1yj8A:undetectable | 4njvD-1yj8A:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ykg | SULFITE REDUCTASE[NADPH] FLAVOPROTEINALPHA-COMPONENT (Escherichiacoli) |
PF00258(Flavodoxin_1) | 5 | GLY A 98ALA A 97VAL A 113THR A 64ILE A 66 | None | 0.94A | 4njvD-1ykgA:undetectable | 4njvD-1ykgA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ash | QUEUINETRNA-RIBOSYLTRANSFERASE (Thermotogamaritima) |
PF01702(TGT) | 5 | GLY A 50ALA A 49ASP A 45ILE A 53ILE A 332 | None | 1.01A | 4njvD-2ashA:undetectable | 4njvD-2ashA:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0w | GAMMA-GLUTAMYLTRANSPEPTIDASE (Escherichiacoli) |
PF01019(G_glu_transpept) | 5 | ASP A 398GLY A 401VAL A 73ILE A 101THR A 163 | None | 0.91A | 4njvD-2e0wA:undetectable | 4njvD-2e0wA:11.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0x | GAMMA-GLUTAMYLTRANSPEPTIDASE (Escherichiacoli) |
PF01019(G_glu_transpept) | 5 | ASP B 398GLY B 401VAL A 73ILE A 101THR A 163 | None | 0.90A | 4njvD-2e0xB:undetectable | 4njvD-2e0xB:19.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 5 | ALA A 28VAL A 32GLY A 54PRO A 86ILE A 89 | LP1 A 201 (-3.5A)NoneLP1 A 201 (-3.6A)LP1 A 201 (-3.9A)LP1 A 201 (-4.2A) | 0.80A | 4njvD-2fmbA:15.2 | 4njvD-2fmbA:33.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 9 | ARG A 8ASP A 25GLY A 27ALA A 28VAL A 32ILE A 53GLY A 55PRO A 86ILE A 89 | LP1 A 201 (-3.5A)LP1 A 201 (-2.3A)LP1 A 201 (-3.8A)LP1 A 201 (-3.5A)NoneLP1 A 201 (-4.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 (-4.2A) | 0.52A | 4njvD-2fmbA:15.2 | 4njvD-2fmbA:33.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h6e | D-ARABINOSE1-DEHYDROGENASE (Sulfolobussolfataricus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 39ALA A 38ILE A 62GLY A 115ILE A 35 | None | 0.94A | 4njvD-2h6eA:undetectable | 4njvD-2h6eA:16.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isq | CYSTEINE SYNTHASE (Arabidopsisthaliana) |
PF00291(PALP) | 5 | GLY A 190ALA A 189GLY A 183ILE A 180PRO A 296 | NoneNonePLP A 400 (-3.4A)PLP A 400 (-4.9A)PLP A 400 (-4.0A) | 0.85A | 4njvD-2isqA:undetectable | 4njvD-2isqA:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pcr | INOSITOL-1-MONOPHOSPHATASE (Aquifexaeolicus) |
PF00459(Inositol_P) | 5 | GLY A 244ALA A 243ILE A 215GLY A 218ILE A 221 | None | 1.13A | 4njvD-2pcrA:undetectable | 4njvD-2pcrA:16.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q0l | THIOREDOXINREDUCTASE (Helicobacterpylori) |
PF07992(Pyr_redox_2) | 5 | ALA A 5VAL A 84ILE A 108GLY A 8ILE A 93 | NoneNoneNoneFAD A 400 (-3.2A)None | 0.79A | 4njvD-2q0lA:undetectable | 4njvD-2q0lA:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q1y | CELL DIVISIONPROTEIN FTSZ (Mycobacteriumtuberculosis) |
PF00091(Tubulin)PF12327(FtsZ_C) | 5 | GLY A 224VAL A 128GLY A 193THR A 157ILE A 159 | None | 0.76A | 4njvD-2q1yA:undetectable | 4njvD-2q1yA:14.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzw | CANDIDAPEPSIN-1 (Candidaalbicans) |
PF00026(Asp) | 5 | ASP A 32GLY A 34ASP A 37PRO A 120ILE A 123 | None | 0.76A | 4njvD-2qzwA:7.3 | 4njvD-2qzwA:13.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r9h | H(+)/CL(-) EXCHANGETRANSPORTER CLCA (Escherichiacoli) |
PF00654(Voltage_CLC) | 5 | GLY A 181ALA A 182ILE A 109PRO A 206ILE A 200 | NoneNone CL A 2 ( 4.9A)NoneNone | 1.04A | 4njvD-2r9hA:undetectable | 4njvD-2r9hA:13.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8ASP A 25GLY A 27ALA A 28ASP A 30GLY A 49ILE A 84 | AB1 A 501 ( 4.7A)AB1 A 501 (-2.4A)AB1 A 501 (-3.9A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-3.5A)AB1 A 501 ( 4.2A) | 0.50A | 4njvD-2rkfA:20.6 | 4njvD-2rkfA:80.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8ASP A 25GLY A 27ALA A 28GLY A 49ILE A 50ILE A 84 | AB1 A 501 ( 4.7A)AB1 A 501 (-2.4A)AB1 A 501 (-3.9A)AB1 A 501 (-3.5A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 ( 4.2A) | 0.40A | 4njvD-2rkfA:20.6 | 4njvD-2rkfA:80.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8ASP A 25GLY A 27ALA A 28ILE A 50PRO A 81ILE A 84 | AB1 A 501 ( 4.7A)AB1 A 501 (-2.4A)AB1 A 501 (-3.9A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.53A | 4njvD-2rkfA:20.6 | 4njvD-2rkfA:80.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uv8 | FATTY ACID SYNTHASESUBUNIT BETA (FAS1) (Saccharomycescerevisiae) |
PF00698(Acyl_transf_1)PF01575(MaoC_dehydratas)PF08354(DUF1729)PF13452(MaoC_dehydrat_N)PF16073(SAT) | 5 | GLY G 621ALA G 620ILE G 617GLY G 648ILE G 676 | NoneFMN G3051 ( 4.7A)NoneNoneNone | 0.94A | 4njvD-2uv8G:undetectable | 4njvD-2uv8G:4.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vca | ALPHA-N-ACETYLGLUCOSAMINIDASE (Clostridiumperfringens) |
PF00754(F5_F8_type_C)PF05089(NAGLU)PF12971(NAGLU_N)PF12972(NAGLU_C) | 5 | GLY A 32VAL A 152ILE A 132GLY A 130ILE A 29 | None | 0.90A | 4njvD-2vcaA:undetectable | 4njvD-2vcaA:7.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vca | ALPHA-N-ACETYLGLUCOSAMINIDASE (Clostridiumperfringens) |
PF00754(F5_F8_type_C)PF05089(NAGLU)PF12971(NAGLU_N)PF12972(NAGLU_C) | 5 | VAL A 152ILE A 132GLY A 130ILE A 74ILE A 29 | None | 1.01A | 4njvD-2vcaA:undetectable | 4njvD-2vcaA:7.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ww9 | SEC SIXTY-ONEPROTEIN HOMOLOG (Saccharomycescerevisiae) |
PF00344(SecY)PF10559(Plug_translocon) | 5 | GLY A 40ALA A 39VAL A 170ILE A 33ILE A 171 | None | 0.92A | 4njvD-2ww9A:undetectable | 4njvD-2ww9A:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yb6 | UBIQUITIN-CONJUGATING ENZYME E2 B (Homo sapiens) |
PF00179(UQ_con) | 5 | GLY A 26ALA A 38VAL A 70ILE A 109ILE A 57 | None | 0.77A | 4njvD-2yb6A:undetectable | 4njvD-2yb6A:17.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c7o | ENDO-1,4-BETA-XYLANASE (Bacillussubtilis) |
PF03422(CBM_6)PF04616(Glyco_hydro_43) | 5 | GLY A 179ALA A 178ILE A 202PRO A 146ILE A 127 | None | 0.88A | 4njvD-3c7oA:undetectable | 4njvD-3c7oA:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cfy | PUTATIVE LUXOREPRESSOR PROTEIN (Vibrioparahaemolyticus) |
PF00072(Response_reg) | 5 | GLY A 96ASP A 66ILE A 78PRO A 47ILE A 68 | None | 1.09A | 4njvD-3cfyA:undetectable | 4njvD-3cfyA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d79 | PUTATIVEUNCHARACTERIZEDPROTEIN PH0734 (Pyrococcushorikoshii) |
PF01472(PUA)PF09183(DUF1947) | 5 | GLY A 95ALA A 96VAL A 106ILE A 111ILE A 100 | None | 1.02A | 4njvD-3d79A:undetectable | 4njvD-3d79A:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dc8 | DIHYDROPYRIMIDINASE (Sinorhizobiummeliloti) |
PF01979(Amidohydro_1) | 5 | GLY A 32VAL A 48ILE A 5THR A 12ILE A 10 | None | 0.88A | 4njvD-3dc8A:undetectable | 4njvD-3dc8A:10.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fbs | OXIDOREDUCTASE (Agrobacteriumfabrum) |
PF07992(Pyr_redox_2) | 5 | GLY A 284ALA A 17ILE A 66GLY A 22ILE A 7 | None | 0.90A | 4njvD-3fbsA:undetectable | 4njvD-3fbsA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fz0 | NUCLEOSIDEHYDROLASE, PUTATIVE (Trypanosomabrucei) |
PF01156(IU_nuc_hydro) | 5 | ALA A 23VAL A 129ILE A 18THR A 10ILE A 8 | None | 0.92A | 4njvD-3fz0A:undetectable | 4njvD-3fz0A:14.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1w | SUGAR ABCTRANSPORTER (Bacillushalodurans) |
PF13407(Peripla_BP_4) | 5 | GLY A 133ALA A 134ASP A 136ILE A 108ILE A 117 | None | 0.91A | 4njvD-3g1wA:undetectable | 4njvD-3g1wA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4o | TRANSLATIONINITIATION FACTORIF-1 (Mycobacteriumtuberculosis) |
PF01176(eIF-1a) | 5 | GLY A 66ALA A 35VAL A 14ILE A 48ILE A 25 | None | 0.92A | 4njvD-3i4oA:undetectable | 4njvD-3i4oA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l84 | TRANSKETOLASE (Campylobacterjejuni) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | GLY A 125ALA A 400ILE A 433THR A 113ILE A 111 | None | 0.97A | 4njvD-3l84A:undetectable | 4njvD-3l84A:8.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | ASP A 25GLY A 27ALA A 28ASP A 30VAL A 32ILE A 47GLY A 49ILE A 50ILE A 84 | None | 0.30A | 4njvD-3mwsA:19.4 | 4njvD-3mwsA:70.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28ASP A 30VAL A 32PRO A 81ILE A 84 | None | 0.54A | 4njvD-3mwsA:19.4 | 4njvD-3mwsA:70.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p0s | CAPSID PROTEIN VP (Lepidopteraniteradensovirus1) |
PF01057(Parvo_NS1) | 5 | VAL A 135ILE A 367GLY A 101THR A 390ILE A 388 | None | 0.69A | 4njvD-3p0sA:undetectable | 4njvD-3p0sA:11.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p4g | ANTIFREEZE PROTEIN (Marinomonasprimoryensis) |
no annotation | 5 | ASP A 103GLY A 99ALA A 98VAL A 124GLY A 137 | CA A 403 ( 2.4A) CA A 403 (-4.1A) CA A 404 (-4.5A)None CA A 405 (-4.1A) | 1.02A | 4njvD-3p4gA:undetectable | 4njvD-3p4gA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pr2 | TRYPTOPHAN SYNTHASEALPHA CHAIN (Salmonellaenterica) |
PF00290(Trp_syntA) | 5 | GLY A 44ALA A 45ILE A 37PRO A 93ILE A 95 | None | 1.05A | 4njvD-3pr2A:undetectable | 4njvD-3pr2A:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3slz | GAG-PRO-POLPOLYPROTEIN (Murine leukemiavirus) |
PF00077(RVP) | 6 | ASP A 32GLY A 34ALA A 35VAL A 39GLY A 56PRO A 89 | 3TL A 126 (-2.4A)3TL A 126 (-3.1A)3TL A 126 ( 4.0A)None3TL A 126 (-3.4A)3TL A 126 (-4.0A) | 0.59A | 4njvD-3slzA:11.7 | 4njvD-3slzA:25.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25GLY A 27ALA A 28ASP A 30VAL A 32 | 017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-3.5A)017 A 201 (-4.2A)None | 0.46A | 4njvD-3t3cA:18.2 | 4njvD-3t3cA:74.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28VAL A 32ILE A 47GLY A 49ILE A 50 | 017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-3.5A)NoneNone017 A 201 (-4.0A)017 A 201 (-3.3A) | 0.41A | 4njvD-3t3cA:18.2 | 4njvD-3t3cA:74.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28ASP A 30GLY A 49ILE A 50ILE A 84 | 017 A 201 (-2.6A)017 A 201 (-3.6A)017 A 201 (-3.4A)017 A 201 (-4.6A)017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.7A) | 0.35A | 4njvD-3ttpA:19.6 | 4njvD-3ttpA:77.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25GLY A 27ALA A 28ASP A 30PRO A 81ILE A 84 | 017 A 201 (-2.6A)017 A 201 (-3.6A)017 A 201 (-3.4A)017 A 201 (-4.6A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.56A | 4njvD-3ttpA:19.6 | 4njvD-3ttpA:77.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8ASP A 25GLY A 27ALA A 28ILE A 47GLY A 49ILE A 50 | None017 A 202 ( 2.5A)017 A 201 ( 3.5A)017 A 201 (-3.4A)017 A 202 (-3.6A)017 A 202 (-2.9A)017 A 201 ( 3.5A) | 0.46A | 4njvD-3u7sA:20.1 | 4njvD-3u7sA:78.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8ASP A 25GLY A 27ALA A 28ILE A 47GLY A 49PRO A 81 | None017 A 202 ( 2.5A)017 A 201 ( 3.5A)017 A 201 (-3.4A)017 A 202 (-3.6A)017 A 202 (-2.9A)017 A 202 (-4.0A) | 0.52A | 4njvD-3u7sA:20.1 | 4njvD-3u7sA:78.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25GLY A 27ALA A 28ASP A 30ILE A 47 | 017 A 202 ( 2.5A)017 A 201 ( 3.5A)017 A 201 (-3.4A)017 A 201 ( 4.0A)017 A 202 (-3.6A) | 0.44A | 4njvD-3u7sA:20.1 | 4njvD-3u7sA:78.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3up8 | PUTATIVE2,5-DIKETO-D-GLUCONIC ACID REDUCTASE B (Sinorhizobiummeliloti) |
PF00248(Aldo_ket_red) | 5 | GLY A 8ALA A 9ASP A 100GLY A 133ILE A 11 | None | 0.94A | 4njvD-3up8A:undetectable | 4njvD-3up8A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3upy | OXIDOREDUCTASE (Brucellaabortus) |
PF03447(NAD_binding_3) | 5 | GLY A 121ALA A 122GLY A 147PRO A 393ILE A 425 | None | 1.03A | 4njvD-3upyA:undetectable | 4njvD-3upyA:13.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wgp | VITAMIN D3 RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | GLY A 304ASP A 299VAL A 297GLY A 164ILE A 310 | None | 0.97A | 4njvD-3wgpA:undetectable | 4njvD-3wgpA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2l | TWO-COMPONENT SYSTEMSENSOR HISTIDINEKINASE/RESPONSE (Bacteroidesthetaiotaomicron) |
PF07494(Reg_prop)PF07495(Y_Y_Y) | 5 | ARG A 505VAL A 558GLY A 515ILE A 500ILE A 548 | None | 0.95A | 4njvD-4a2lA:undetectable | 4njvD-4a2lA:8.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ao7 | ESTERASE (unidentified) |
PF12146(Hydrolase_4) | 5 | ALA A 125VAL A 31ILE A 119PRO A 82ILE A 79 | None | 0.87A | 4njvD-4ao7A:undetectable | 4njvD-4ao7A:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ev4 | CARBAPENEM-HYDROLIZING BETA-LACTAMASESFC-1 (Serratiafonticola) |
PF13354(Beta-lactamase2) | 5 | ASP A 131GLY A 133ALA A 134ILE A 95ILE A 113 | NoneHAR A 100 ( 3.6A)NoneNoneNone | 1.11A | 4njvD-4ev4A:undetectable | 4njvD-4ev4A:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gah | THIOESTERASESUPERFAMILY MEMBER 4 (Homo sapiens) |
PF03061(4HBT) | 5 | GLY A 154ALA A 157ASP A 161ILE A 188ILE A 182 | NoneNone0ET A 301 (-3.6A)NoneNone | 1.07A | 4njvD-4gahA:undetectable | 4njvD-4gahA:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hnl | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Enterococcusgallinarum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ARG A 56GLY A 34ALA A 96ILE A 67ILE A 93 | None | 1.02A | 4njvD-4hnlA:undetectable | 4njvD-4hnlA:13.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j0q | ELONGATION FACTORTU-A (Pseudomonasputida) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 5 | ARG A 252GLY A 284VAL A 230ILE A 224GLY A 226 | None | 1.02A | 4njvD-4j0qA:undetectable | 4njvD-4j0qA:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jc5 | TRANSMEMBRANEPROTEIN 173 (Mus musculus) |
PF15009(TMEM173) | 5 | GLY A 233GLY A 165ILE A 164PRO A 172ILE A 229 | None | 0.86A | 4njvD-4jc5A:undetectable | 4njvD-4jc5A:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m2j | AMINOTRANSFERASE (Streptomyceslavendulae) |
PF00155(Aminotran_1_2) | 5 | GLY A 278ALA A 281VAL A 311GLY A 228ILE A 200 | None | 1.01A | 4njvD-4m2jA:undetectable | 4njvD-4m2jA:14.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nbq | POLYRIBONUCLEOTIDENUCLEOTIDYLTRANSFERASE (Coxiellaburnetii) |
PF00013(KH_1)PF00575(S1)PF01138(RNase_PH)PF03725(RNase_PH_C)PF03726(PNPase) | 5 | GLY A 132ALA A 133VAL A 60THR A 90ILE A 94 | None | 1.09A | 4njvD-4nbqA:undetectable | 4njvD-4nbqA:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pyt | UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINEREDUCTASE (unidentified) |
PF01565(FAD_binding_4)PF02873(MurB_C) | 5 | GLY A 267ALA A 268ILE A 262THR A 26ILE A 30 | None | 1.12A | 4njvD-4pytA:undetectable | 4njvD-4pytA:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s05 | DNA-BINDINGTRANSCRIPTIONALREGULATOR BASR (Klebsiellapneumoniae) |
PF00072(Response_reg)PF00486(Trans_reg_C) | 5 | GLY A 94ALA A 95ILE A 48THR A 79ILE A 77 | NoneNoneNoneBEF A 301 (-3.7A)None | 1.12A | 4njvD-4s05A:undetectable | 4njvD-4s05A:18.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 7 | ARG A 10ASP A 32GLY A 34ALA A 35VAL A 39GLY A 58ILE A 100 | None4B1 A 201 (-2.9A)4B1 A 201 ( 4.6A)4B1 A 201 (-3.6A)None4B1 A 201 (-3.4A)4B1 A 201 (-4.8A) | 0.65A | 4njvD-4ydfA:13.4 | 4njvD-4ydfA:33.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ywl | CELL DIVISIONCONTROL PROTEIN 21 (Pyrococcusfuriosus) |
PF14551(MCM_N)PF17207(MCM_OB) | 5 | GLY A 225VAL A 221ILE A 187GLY A 205ILE A 206 | None | 0.88A | 4njvD-4ywlA:undetectable | 4njvD-4ywlA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8d | CARBOHYDRATE BINDINGFAMILY 6 (Ruminiclostridiumthermocellum) |
PF04616(Glyco_hydro_43) | 5 | ALA A 45ILE A 75ILE A 78PRO A 136ILE A 110 | GOL A1340 (-3.6A)NoneNoneNoneGOL A1340 (-4.2A) | 0.98A | 4njvD-5a8dA:undetectable | 4njvD-5a8dA:14.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b18 | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ARG A 8GLY A 27ALA A 28ASP A 30ILE A 84 | None | 0.51A | 4njvD-5b18A:18.4 | 4njvD-5b18A:78.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b18 | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ARG A 8GLY A 27ALA A 28GLY A 49ILE A 84 | None | 0.79A | 4njvD-5b18A:18.4 | 4njvD-5b18A:78.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cs4 | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF08326(ACC_central) | 5 | ALA A1361ILE A1385GLY A1340ILE A1341ILE A1425 | None | 1.11A | 4njvD-5cs4A:undetectable | 4njvD-5cs4A:11.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ehf | LACCASE (Antrodiellafaginea) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | GLY A 360ALA A 361ILE A 353PRO A 444ILE A 469 | None | 1.08A | 4njvD-5ehfA:undetectable | 4njvD-5ehfA:11.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5erp | DESMOCOLLIN-2 (Homo sapiens) |
PF00028(Cadherin) | 5 | VAL A 383GLY A 429ILE A 409PRO A 379THR A 380 | NoneNAG A 806 ( 4.5A)NAG A 806 (-3.5A)NoneNone | 1.13A | 4njvD-5erpA:undetectable | 4njvD-5erpA:13.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ewt | EXODEOXYRIBONUCLEASEIII XTH (Sulfolobusislandicus) |
PF03372(Exo_endo_phos) | 5 | GLY A 154ALA A 155ILE A 161GLY A 163ILE A 147 | None | 0.99A | 4njvD-5ewtA:undetectable | 4njvD-5ewtA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g56 | CARBOHYDRATE BINDINGFAMILY 6 (Ruminiclostridiumthermocellum) |
PF00150(Cellulase)PF03422(CBM_6) | 5 | GLY A 372ALA A 363VAL A 437GLY A 566ILE A 516 | None | 1.05A | 4njvD-5g56A:undetectable | 4njvD-5g56A:7.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j1k | TOXR-ACTIVATED GENE(TAGE) (Helicobacterpylori) |
PF01551(Peptidase_M23) | 5 | GLY A 230ALA A 180VAL A 186GLY A 234ILE A 227 | None | 1.05A | 4njvD-5j1kA:undetectable | 4njvD-5j1kA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jx3 | URACIL-DNAGLYCOSYLASE (Vaccinia virus) |
no annotation | 5 | ALA A 93ILE A 217GLY A 215ILE A 113ILE A 89 | None | 1.06A | 4njvD-5jx3A:undetectable | 4njvD-5jx3A:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nks | DIHYDROPYRIMIDINASE-RELATED PROTEIN 4 (Homo sapiens) |
no annotation | 5 | GLY A 46ALA A 33VAL A 65ILE A 19ILE A 24 | GLY A 46 ( 0.0A)ALA A 33 ( 0.0A)VAL A 65 ( 0.6A)ILE A 19 ( 0.7A)ILE A 24 ( 0.7A) | 1.13A | 4njvD-5nksA:undetectable | 4njvD-5nksA:11.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | ARG A 8ASP A 25GLY A 27ALA A 28ASP A 30VAL A 32ILE A 47GLY A 49ILE A 50ILE A 84 | None | 0.41A | 4njvD-5t2zA:20.0 | 4njvD-5t2zA:85.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | ARG A 8ASP A 25GLY A 27ALA A 28VAL A 32ILE A 47GLY A 49PRO A 81ILE A 84 | None | 0.56A | 4njvD-5t2zA:20.0 | 4njvD-5t2zA:85.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t89 | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF00047(ig)PF07679(I-set)PF13927(Ig_3) | 5 | ARG X 261GLY X 316PRO X 257THR X 256ILE X 229 | None | 0.93A | 4njvD-5t89X:undetectable | 4njvD-5t89X:10.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6fiv | RETROPEPSIN (Felineimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ARG A 13ASP A 30GLY A 32ALA A 33GLY A 58 | None3TL A 201 (-3.5A)3TL A 201 (-3.4A)3TL A 201 (-4.0A)3TL A 201 (-3.4A) | 0.16A | 4njvD-6fivA:15.9 | 4njvD-6fivA:31.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 6 | ASP A 25GLY A 27ALA A 28ASP A 30GLY A 49ILE A 84 | NIU A 100 (-2.8A)NIU A 100 (-4.5A)NIU A 100 (-3.6A)NoneNIU A 100 ( 3.8A)None | 0.58A | 4njvD-6upjA:18.1 | 4njvD-6upjA:47.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 6 | ASP A 25GLY A 27ALA A 28ASP A 30PRO A 81ILE A 84 | NIU A 100 (-2.8A)NIU A 100 (-4.5A)NIU A 100 (-3.6A)NoneNoneNone | 0.71A | 4njvD-6upjA:18.1 | 4njvD-6upjA:47.47 |