SIMILAR PATTERNS OF AMINO ACIDS FOR 4NJK_A_SAMA302
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ecg | GLUTAMINEPHOSPHORIBOSYLPYROPHOSPHATEAMIDOTRANSFERASE (Escherichiacoli) |
PF00156(Pribosyltran)PF13522(GATase_6) | 5 | GLU A 209ASP A 263GLU A 303VAL A 22ASP A 214 | NoneNonePIN A 506 (-4.7A)NoneNone | 1.25A | 4njkA-1ecgA:2.2 | 4njkA-1ecgA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ji6 | PESTICIDIAL CRYSTALPROTEIN CRY3BB (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 5 | THR A 378GLU A 366ASN A 363LYS A 392VAL A 390 | None | 0.85A | 4njkA-1ji6A:undetectable | 4njkA-1ji6A:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1moz | ADP-RIBOSYLATIONFACTOR-LIKE PROTEIN1 (Saccharomycescerevisiae) |
PF00025(Arf) | 5 | ASP A 68THR A 45GLU A 55ASN A 65ASP A 27 | GDP A 184 (-3.5A)NoneNoneNoneNone | 1.37A | 4njkA-1mozA:1.5 | 4njkA-1mozA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x55 | ASPARAGINYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 5 | GLU A 314GLU A 315LYS A 294VAL A 296ASP A 307 | None | 1.29A | 4njkA-1x55A:undetectable | 4njkA-1x55A:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c6w | PENICILLIN-BINDINGPROTEIN 1A (Streptococcuspneumoniae) |
PF00905(Transpeptidase) | 5 | THR B 332GLU B 481ASN B 274VAL B 279GLN B 282 | None | 1.34A | 4njkA-2c6wB:undetectable | 4njkA-2c6wB:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ipc | PREPROTEINTRANSLOCASE SECASUBUNIT (Thermusthermophilus) |
PF01043(SecA_PP_bind)PF07516(SecA_SW)PF07517(SecA_DEAD) | 5 | GLU A 742THR A 390GLU A 98GLU A 391GLN A 738 | None | 1.48A | 4njkA-2ipcA:0.4 | 4njkA-2ipcA:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y6i | COLLAGENASE (Hathewayahistolytica) |
PF01752(Peptidase_M9)PF08453(Peptidase_M9_N) | 5 | ASP A 239THR A 235ASN A 228VAL A 265GLN A 268 | None | 1.48A | 4njkA-2y6iA:0.8 | 4njkA-2y6iA:15.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gtd | FUMARATE HYDRATASECLASS II (Rickettsiaprowazekii) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | THR A 100ASN A 105LYS A 52VAL A 134ASP A 132 | MLI A 462 (-2.8A)NoneNoneNoneNone | 1.35A | 4njkA-3gtdA:undetectable | 4njkA-3gtdA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lmd | GERANYLGERANYLPYROPHOSPHATESYNTHASE (Corynebacteriumglutamicum) |
PF00348(polyprenyl_synt) | 5 | ASP A 239GLU A 177ASN A 192LYS A 197ASP A 238 | None | 1.29A | 4njkA-3lmdA:0.0 | 4njkA-3lmdA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ogr | BETA-GALACTOSIDASE (Trichodermareesei) |
PF01301(Glyco_hydro_35)PF10435(BetaGal_dom2)PF13363(BetaGal_dom3)PF13364(BetaGal_dom4_5) | 5 | THR A 813GLU A 200ASN A 199VAL A 219ASP A 162 | NoneGAL A1024 (-2.5A)GAL A1024 (-3.1A)NoneNone | 1.50A | 4njkA-3ogrA:3.0 | 4njkA-3ogrA:13.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tv2 | FUMARATE HYDRATASE,CLASS II (Burkholderiapseudomallei) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | THR A 240ASN A 245LYS A 192VAL A 274ASP A 272 | None | 1.37A | 4njkA-3tv2A:undetectable | 4njkA-3tv2A:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a0w | T-COMPLEX PROTEIN 1SUBUNIT BETA (Bos taurus) |
PF00118(Cpn60_TCP1) | 5 | GLU A 482GLU A 95GLU A 401LYS A 487ASP A 84 | None | 1.50A | 4njkA-4a0wA:1.3 | 4njkA-4a0wA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cmr | GLYCOSYLHYDROLASE/DEACETYLASE FAMILY PROTEIN (Pyrococcus sp.ST04) |
no annotation | 5 | GLU A 580ASP A 16THR A 574ASN A 587VAL A 38 | None | 1.40A | 4njkA-4cmrA:undetectable | 4njkA-4cmrA:16.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hgv | FUMARATE HYDRATASECLASS II (Sinorhizobiummeliloti) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | THR A 110ASN A 115LYS A 62VAL A 144ASP A 142 | None | 1.40A | 4njkA-4hgvA:undetectable | 4njkA-4hgvA:21.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nji | 7-CARBOXY-7-DEAZAGUANINE SYNTHASE (Burkholderiamultivorans) |
PF13394(Fer4_14) | 12 | GLU A 15ASP A 50THR A 51THR A 90GLU A 93GLU A 116ASN A 118LYS A 149VAL A 151GLN A 173ASP A 176GLN A 202 | 2K8 A 303 (-3.6A)SAM A 302 (-3.5A) MG A 304 ( 3.5A)2K8 A 303 ( 2.9A)SAM A 302 (-4.2A)2K8 A 303 ( 3.9A)SF4 A 301 ( 4.2A)SAM A 302 (-3.7A)SAM A 302 (-4.5A)SAM A 302 (-4.0A)NoneSAM A 302 (-3.3A) | 0.13A | 4njkA-4njiA:39.6 | 4njkA-4njiA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p05 | ARYLSULFATESULFOTRANSFERASEASST (Escherichiacoli) |
PF05935(Arylsulfotrans)PF17425(Arylsulfotran_N) | 5 | ASP A 453THR A 434GLN A 333ASP A 317GLN A 459 | None | 1.44A | 4njkA-4p05A:undetectable | 4njkA-4p05A:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5az4 | FLAGELLAR HOOKSUBUNIT PROTEIN (Campylobacterjejuni) |
PF07196(Flagellin_IN)PF07559(FlaE) | 5 | GLU A 508GLU A 504VAL A 537GLN A 511ASP A 513 | None | 1.47A | 4njkA-5az4A:undetectable | 4njkA-5az4A:16.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5gqo | SINGLE-STRANDEDDNA-BINDING PROTEIN (Mycolicibacteriumsmegmatis) |
PF00436(SSB) | 5 | THR A 16GLU A 99ASN A 57VAL A 105ASP A 74 | None | 1.47A | 4njkA-5gqoA:undetectable | 4njkA-5gqoA:30.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ixm | LPS-ASSEMBLY PROTEINLPTDLPS-ASSEMBLYLIPOPROTEIN LPTE (Yersiniapestis;Yersinia pestis) |
PF04453(OstA_C)PF04390(LptE) | 5 | GLU B 121ASN A 102LYS A 149GLN A 168GLN A 188 | None | 1.37A | 4njkA-5ixmB:undetectable | 4njkA-5ixmB:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jpv | ASIALOGLYCOPROTEINRECEPTOR 1 (Homo sapiens) |
PF00059(Lectin_C) | 5 | GLU A 277ASP A 224THR A 226THR A 192GLU A 196 | CA A 304 (-2.3A)NoneNone CA A 304 ( 4.8A) CA A 304 (-2.4A) | 1.22A | 4njkA-5jpvA:undetectable | 4njkA-5jpvA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mkk | MULTIDRUG RESISTANCEABC TRANSPORTERATP-BINDING ANDPERMEASE PROTEINMULTIDRUG RESISTANCEABC TRANSPORTERATP-BINDING ANDPERMEASE PROTEIN (Thermusthermophilus;Thermusthermophilus) |
PF00005(ABC_tran)PF00664(ABC_membrane)PF00005(ABC_tran)PF00664(ABC_membrane) | 5 | THR A 395THR B 373GLU A 599ASP A 522GLN A 441 | SO4 A 701 (-4.1A)SO4 B 601 (-4.4A)NoneNoneNone | 1.38A | 4njkA-5mkkA:undetectable | 4njkA-5mkkA:15.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5th5 | 7-CARBOXY-7-DEAZAGUANINE SYNTHASE (Bacillussubtilis) |
PF04055(Radical_SAM)PF13394(Fer4_14) | 7 | GLU A 18ASP A 42GLU A 108LYS A 161VAL A 163GLN A 188GLN A 231 | 7C5 A 302 (-3.2A)7C5 A 302 ( 3.0A)7C5 A 302 ( 3.7A)7C5 A 302 (-3.5A)7C5 A 302 (-4.6A)7C5 A 302 (-4.0A)7C5 A 302 (-3.2A) | 0.41A | 4njkA-5th5A:19.6 | 4njkA-5th5A:33.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d3u | ULVAN LYASE (Nonlabensulvanivorans) |
no annotation | 5 | THR A 49GLU A 47LYS A 226VAL A 196ASP A 187 | None | 1.43A | 4njkA-6d3uA:undetectable | 4njkA-6d3uA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g2j | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN5NADH DEHYDROGENASE[UBIQUINONE] 1 BETASUBCOMPLEX SUBUNIT10 (Mus musculus;Mus musculus) |
no annotationno annotation | 5 | GLU p 127GLU L 75ASN p 103VAL p 134GLN p 130 | None | 1.49A | 4njkA-6g2jp:undetectable | 4njkA-6g2jp:undetectable |