SIMILAR PATTERNS OF AMINO ACIDS FOR 4NED_A_PFNA709

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)

(Escherichia
coli) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain) 		4 ASP B1657
VAL B1662
SER B1739
ALA B1751
 None
 0.96A 4nedA-1a9xB:
0.3		 4nedA-1a9xB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bix AP ENDONUCLEASE 1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ASP A 219
ASP A 251
SER A 298
ALA A 263
 None
 1.18A 4nedA-1bixA:
undetectable		 4nedA-1bixA:
22.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		4 ASP A 378
VAL A 461
ASP A 462
SER A 676
 None
 0.88A 4nedA-1biyA:
41.1		 4nedA-1biyA:
91.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 ASP A 149
ASP A 413
SER A 421
PHE A 154
 None
 1.14A 4nedA-1dppA:
4.6		 4nedA-1dppA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8v MATURE CAPSID
PROTEIN BETA

(Pariacoto virus) 		PF01829
(Peptidase_A6) 		4 VAL A 123
ASP A 103
SER A 180
ALA A 226
 None
 1.16A 4nedA-1f8vA:
undetectable		 4nedA-1f8vA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gr0 INOSITOL-3-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01658
(Inos-1-P_synth) 		4 VAL A  70
ASP A  69
SER A  86
ALA A  27
 NAD  A1000 (-4.5A)
NAD  A1000 (-2.9A)
None
None
 1.21A 4nedA-1gr0A:
0.4		 4nedA-1gr0A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 VAL A 610
ASP A 749
SER A 733
PHE A 739
 None
 1.21A 4nedA-1h17A:
undetectable		 4nedA-1h17A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB

(Thermotoga
maritima) 		PF06723
(MreB_Mbl) 		4 ASP A  67
ASP A 180
SER A  30
ALA A  71
 None
 1.12A 4nedA-1jcfA:
undetectable		 4nedA-1jcfA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		4 VAL A 145
SER A 199
ALA A 170
PHE A  35
 None
 1.21A 4nedA-1jmyA:
undetectable		 4nedA-1jmyA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko8 GLUCONATE KINASE

(Escherichia
coli) 		PF01202
(SKI) 		4 ASP A  38
SER A  19
ALA A  25
PHE A  36
 MG  A 201 ( 4.2A)
None
None
None
 1.23A 4nedA-1ko8A:
undetectable		 4nedA-1ko8A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwd ISOCITRATE
DEHYDROGENASE

(Sus scrofa) 		PF00180
(Iso_dh) 		4 ASP A 279
ASP A 275
SER A  95
ALA A 308
 MN  A 501 (-4.0A)
MN  A 501 (-2.8A)
ICT  A 701 ( 2.4A)
ICT  A 701 ( 4.2A)
 1.23A 4nedA-1lwdA:
undetectable		 4nedA-1lwdA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE

(Acidaminococcus
fermentans) 		PF01144
(CoA_trans) 		4 VAL B  88
SER A 102
ALA A  53
PHE A  26
 None
 1.24A 4nedA-1poiB:
undetectable		 4nedA-1poiB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus) 		PF01791
(DeoC) 		4 ASP A  89
VAL A 120
SER A 200
ALA A 182
 HPD  A 801 ( 4.6A)
None
None
HPD  A 801 (-3.2A)
 1.24A 4nedA-1ub3A:
undetectable		 4nedA-1ub3A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		4 ASP A  72
ASP A  55
SER A 101
ALA A  74
 None
 1.05A 4nedA-1v02A:
undetectable		 4nedA-1v02A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A 157
SER A  39
ALA A 164
PHE A 198
 None
 1.05A 4nedA-1vj0A:
undetectable		 4nedA-1vj0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01795
(Methyltransf_5) 		4 VAL A   7
SER A 262
ALA A 275
PHE A 234
 None
 1.13A 4nedA-1wg8A:
undetectable		 4nedA-1wg8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		4 ASP A  44
VAL A  80
ALA A 258
PHE A 260
 None
 1.16A 4nedA-1wpwA:
undetectable		 4nedA-1wpwA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjl ANNEXIN A2

(Homo sapiens) 		PF00191
(Annexin) 		4 VAL A 298
ASP A 299
SER A 134
ALA A 271
 None
 1.17A 4nedA-1xjlA:
undetectable		 4nedA-1xjlA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Staphylococcus
aureus) 		PF04131
(NanE) 		4 VAL A  71
ASP A  94
ALA A 134
PHE A 139
 None
 0.99A 4nedA-1y0eA:
undetectable		 4nedA-1y0eA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		4 VAL A  65
SER A  49
ALA A 163
PHE A 154
 None
 1.23A 4nedA-2a9vA:
undetectable		 4nedA-2a9vA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 VAL A 343
ASP A 138
ALA A 196
PHE A 200
 None
 1.23A 4nedA-2cfzA:
undetectable		 4nedA-2cfzA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyc TYROSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		4 ASP A 175
VAL A 134
ALA A 121
PHE A  71
 TYR  A 701 (-3.4A)
None
None
TYR  A 701 (-4.4A)
 1.17A 4nedA-2cycA:
undetectable		 4nedA-2cycA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h84 STEELY1

(Dictyostelium
discoideum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 VAL A2839
ASP A2981
ALA A3108
PHE A3112
 None
 1.14A 4nedA-2h84A:
undetectable		 4nedA-2h84A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiv THERMOSTABLE DNA
LIGASE

(Sulfolobus
solfataricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ASP A 176
ASP A  52
SER A 279
ALA A 205
 None
 1.23A 4nedA-2hivA:
undetectable		 4nedA-2hivA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
UNCHARACTERIZED
PROTEIN YER030W

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF09649
(CHZ)
PF16211
(Histone_H2A_C) 		4 ASP B  50
VAL A 157
SER A  26
ALA A 168
 None
 1.12A 4nedA-2jssB:
undetectable		 4nedA-2jssB:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3c APEX NUCLEASE 1

(Danio rerio) 		PF03372
(Exo_endo_phos) 		4 ASP A 212
ASP A 243
SER A 290
ALA A 255
 None
 1.23A 4nedA-2o3cA:
undetectable		 4nedA-2o3cA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Aquifex
aeolicus) 		PF13561
(adh_short_C2) 		4 VAL A 240
SER A 106
ALA A 212
PHE A 218
 None
 1.12A 4nedA-2p91A:
undetectable		 4nedA-2p91A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woo ATPASE GET3

(Schizosaccharomyces
pombe) 		PF02374
(ArsA_ATPase) 		4 VAL A  24
ASP A 147
ALA A  64
PHE A  65
 None
 1.04A 4nedA-2wooA:
undetectable		 4nedA-2wooA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 ASP A 191
SER A 240
ALA A 220
PHE A 187
 None
 1.12A 4nedA-2xfgA:
undetectable		 4nedA-2xfgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
BETA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF12838
(Fer4_7) 		4 VAL B 182
ASP B 200
ALA B 346
PHE B 354
 None
 1.24A 4nedA-2xsjB:
undetectable		 4nedA-2xsjB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		4 ASP A 392
VAL A 395
ASP A 394
ALA A 495
 None
 1.06A 4nedA-2zwaA:
undetectable		 4nedA-2zwaA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP B
DNA POLYMERASE
SLIDING CLAMP C

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ASP A 149
VAL A 142
ASP A 145
PHE C 109
 None
 1.10A 4nedA-3aizA:
undetectable		 4nedA-3aizA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b40 PROBABLE DIPEPTIDASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		4 VAL A 262
ASP A 241
SER A 388
ALA A  97
 None
 1.13A 4nedA-3b40A:
undetectable		 4nedA-3b40A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT

(Escherichia
coli) 		PF13085
(Fer2_3)
PF13183
(Fer4_8) 		4 ASP B 101
VAL B  17
ASP B  18
ALA B  24
 None
 1.20A 4nedA-3cirB:
undetectable		 4nedA-3cirB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 ASP A 120
VAL A 151
ASP A 152
ALA A  37
 None
 1.14A 4nedA-3ctzA:
undetectable		 4nedA-3ctzA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 22 KDA
SUBUNIT
TRANSPORT PROTEIN
PARTICLE 23 KDA
SUBUNIT
TRANSPORT PROTEIN
PARTICLE 31 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF04051
(TRAPP)
PF04099
(Sybindin) 		4 ASP A 188
ASP D  70
ALA B  63
PHE B 221
 None
 1.23A 4nedA-3cueA:
undetectable		 4nedA-3cueA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d22 THIOREDOXIN H-TYPE

(Populus
trichocarpa x
Populus
deltoides) 		PF00085
(Thioredoxin) 		4 VAL A  85
ASP A  84
SER A  61
ALA A  22
 None
 1.17A 4nedA-3d22A:
undetectable		 4nedA-3d22A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh1 TRNA-SPECIFIC
ADENOSINE DEAMINASE
2

(Homo sapiens) 		PF14437
(MafB19-deam) 		4 VAL A 104
SER A 136
ALA A 141
PHE A 152
 None
 1.09A 4nedA-3dh1A:
undetectable		 4nedA-3dh1A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fc7 HTR-LIKE PROTEIN

(Haloarcula
marismortui) 		PF08448
(PAS_4) 		4 VAL A 212
ASP A 210
SER A 237
ALA A 195
 None
 0.96A 4nedA-3fc7A:
undetectable		 4nedA-3fc7A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkd L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		4 ASP A 166
VAL A 170
ALA A  79
PHE A  80
 None
 1.16A 4nedA-3fkdA:
undetectable		 4nedA-3fkdA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2) 		4 VAL A 434
ASP A 104
ALA A 466
PHE A 639
 None
 1.22A 4nedA-3gyxA:
undetectable		 4nedA-3gyxA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h84 ATPASE GET3

(Saccharomyces
cerevisiae) 		PF02374
(ArsA_ATPase) 		4 VAL A  23
ASP A 166
ALA A  65
PHE A  66
 None
 1.17A 4nedA-3h84A:
undetectable		 4nedA-3h84A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibg ATPASE, SUBUNIT OF
THE GET COMPLEX

(Aspergillus
fumigatus) 		PF02374
(ArsA_ATPase) 		4 VAL A  31
ASP A 158
ALA A  71
PHE A  72
 None
 1.24A 4nedA-3ibgA:
undetectable		 4nedA-3ibgA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io3 DEHA2D07832P

(Debaryomyces
hansenii) 		PF02374
(ArsA_ATPase) 		4 VAL A  23
ASP A 162
ALA A  65
PHE A  66
 None
ADP  A 590 ( 4.7A)
None
None
 1.07A 4nedA-3io3A:
undetectable		 4nedA-3io3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muu STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop) 		4 VAL A 521
SER A 502
ALA A 646
PHE A 647
 None
 1.11A 4nedA-3muuA:
undetectable		 4nedA-3muuA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF00621
(RhoGEF) 		4 VAL A 649
SER A 761
ALA A 713
PHE A 729
 None
 1.07A 4nedA-3odwA:
undetectable		 4nedA-3odwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF00621
(RhoGEF) 		4 VAL A 649
SER A 761
ALA A 713
PHE A 729
 None
 1.06A 4nedA-3odxA:
undetectable		 4nedA-3odxA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		4 ASP A  62
ASP A  45
SER A  91
ALA A  64
 None
 0.98A 4nedA-3ptkA:
undetectable		 4nedA-3ptkA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slu M23 PEPTIDASE DOMAIN
PROTEIN

(Neisseria
meningitidis) 		PF01551
(Peptidase_M23) 		4 VAL A 230
SER A 162
ALA A 226
PHE A 239
 None
 1.20A 4nedA-3sluA:
undetectable		 4nedA-3sluA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		4 ASP A  69
ASP A  52
SER A  98
ALA A  71
 None
 0.99A 4nedA-3u5uA:
undetectable		 4nedA-3u5uA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3us8 ISOCITRATE
DEHYDROGENASE [NADP]

(Sinorhizobium
meliloti) 		PF00180
(Iso_dh) 		4 ASP A 277
ASP A 273
SER A  94
ALA A 306
 None
None
SO4  A 501 (-2.3A)
None
 1.06A 4nedA-3us8A:
undetectable		 4nedA-3us8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		4 VAL A 320
SER A  35
ALA A   2
PHE A   8
 None
 1.13A 4nedA-3vv3A:
undetectable		 4nedA-3vv3A:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1

(Aspergillus
oryzae) 		PF07519
(Tannase) 		4 VAL A 130
SER A 120
ALA A 139
PHE A  87
 None
 1.18A 4nedA-3wmtA:
undetectable		 4nedA-3wmtA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ASP A 623
ASP A 295
ALA A 274
PHE A 705
 None
 0.95A 4nedA-4aj9A:
undetectable		 4nedA-4aj9A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c57 NANOBODY

(Lama glama) 		PF07686
(V-set) 		4 VAL C  42
SER C 119
ALA C  25
PHE C  30
 None
 1.14A 4nedA-4c57C:
undetectable		 4nedA-4c57C:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exl PHOSPHATE-BINDING
PROTEIN PSTS 1

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		4 ASP A 102
VAL A 105
SER A  38
ALA A  89
 None
 0.98A 4nedA-4exlA:
8.1		 4nedA-4exlA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fim LACTOTRANSFERRIN

(Bos taurus) 		PF00405
(Transferrin) 		4 ASP A 378
VAL A 461
ASP A 462
SER A 676
 None
 0.30A 4nedA-4fimA:
59.4		 4nedA-4fimA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp8 ANTIBODY C05, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP H 100
ASP H 101
SER H  27
ALA H  33
 None
 1.17A 4nedA-4fp8H:
undetectable		 4nedA-4fp8H:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8n CONJUGATED
POLYKETONE REDUCTASE
C2

(Candida
parapsilosis) 		PF00248
(Aldo_ket_red) 		4 VAL A 259
ASP A  58
SER A 161
ALA A  62
 NDP  A3001 (-4.4A)
NDP  A3001 (-3.8A)
NDP  A3001 (-2.7A)
None
 1.20A 4nedA-4h8nA:
undetectable		 4nedA-4h8nA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 VAL M 120
SER M 156
ALA M 240
PHE M 239
 None
 1.21A 4nedA-4heaM:
undetectable		 4nedA-4heaM:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ASP A 261
VAL A 258
SER A 372
ALA A 285
 None
IOD  A 534 ( 4.6A)
IOD  A 508 ( 4.3A)
None
 1.19A 4nedA-4hjhA:
undetectable		 4nedA-4hjhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 VAL A 402
SER A  12
ALA A 422
PHE A 432
 None
 1.19A 4nedA-4hjlA:
undetectable		 4nedA-4hjlA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		4 VAL A 530
SER A 500
ALA A 492
PHE A 286
 None
 1.10A 4nedA-4ia5A:
undetectable		 4nedA-4ia5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imm OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFGL

(Moraxella
catarrhalis) 		PF13360
(PQQ_2) 		4 ASP A 251
VAL A 191
SER A 151
ALA A 155
 CA  A 407 ( 2.3A)
None
None
NA  A 404 (-4.2A)
 0.94A 4nedA-4immA:
undetectable		 4nedA-4immA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k22 PROTEIN VISC

(Escherichia
coli) 		PF01494
(FAD_binding_3) 		4 ASP A 289
ASP A 308
SER A 342
ALA A 276
 None
 0.99A 4nedA-4k22A:
undetectable		 4nedA-4k22A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Neisseria
meningitidis) 		PF13561
(adh_short_C2) 		4 VAL A 226
SER A  91
ALA A 198
PHE A 204
 None
NAD  A 301 (-3.1A)
NAD  A 301 ( 3.9A)
None
 0.94A 4nedA-4m87A:
undetectable		 4nedA-4m87A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Rhodoferax
ferrireducens) 		PF03480
(DctP) 		4 ASP A  45
SER A 215
ALA A 278
PHE A 274
 None
MLI  A 401 (-2.8A)
None
None
 0.95A 4nedA-4mcoA:
1.9		 4nedA-4mcoA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2z GH62
ARABINOFURANOSIDASE

(Podospora
anserina) 		PF03664
(Glyco_hydro_62) 		4 VAL A 164
ASP A 165
SER A  64
PHE A 243
 TRS  A 402 ( 3.8A)
TRS  A 402 (-2.7A)
TRS  A 402 ( 4.4A)
None
 1.17A 4nedA-4n2zA:
undetectable		 4nedA-4n2zA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nap EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7

(Desulfovibrio
alaskensis) 		PF03480
(DctP) 		4 VAL A 215
ASP A 214
SER A 153
PHE A 148
 None
DTR  A 401 (-3.3A)
None
None
 1.18A 4nedA-4napA:
2.1		 4nedA-4napA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		4 VAL A 235
ASP A  52
SER A 146
ALA A  56
 None
 1.24A 4nedA-4otkA:
undetectable		 4nedA-4otkA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvi GH62 HYDROLASE

(Mycothermus
thermophilus) 		PF03664
(Glyco_hydro_62) 		4 VAL A 170
ASP A 171
SER A  70
PHE A 261
 None
 1.19A 4nedA-4pviA:
undetectable		 4nedA-4pviA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ASP A 490
ASP A 578
SER A 556
ALA A 566
 None
 1.20A 4nedA-4q1vA:
undetectable		 4nedA-4q1vA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 ASP A 315
ASP A 350
ALA A 244
PHE A 245
 LLP  A 353 ( 2.9A)
LLP  A 353 ( 3.8A)
None
None
 1.12A 4nedA-4q6rA:
undetectable		 4nedA-4q6rA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ric FANCONI-ASSOCIATED
NUCLEASE 1

(Homo sapiens) 		PF08774
(VRR_NUC) 		4 ASP A 560
VAL A 574
ALA A 865
PHE A 866
 None
 1.09A 4nedA-4ricA:
undetectable		 4nedA-4ricA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 ASP P 122
VAL P 153
ASP P 154
ALA P  38
 None
 1.17A 4nedA-4s2tP:
undetectable		 4nedA-4s2tP:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING

(Xanthobacter
autotrophicus) 		PF02826
(2-Hacid_dh_C) 		4 VAL A  15
ASP A  16
SER A 285
ALA A 292
 None
 1.20A 4nedA-4xa8A:
undetectable		 4nedA-4xa8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		4 VAL A  18
ASP A  19
SER A  31
ALA A  38
 None
 1.21A 4nedA-4xcvA:
undetectable		 4nedA-4xcvA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 ASP A 820
VAL A 826
ASP A 827
ALA A 787
 None
 1.16A 4nedA-4xgtA:
undetectable		 4nedA-4xgtA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfolobus
acidocaldarius) 		PF00180
(Iso_dh) 		4 ASP A  45
VAL A  81
ALA A 259
PHE A 261
 None
 1.11A 4nedA-4y1pA:
undetectable		 4nedA-4y1pA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		4 ASP C 153
VAL C 210
SER C  71
ALA A 162
 None
 1.05A 4nedA-4yfaC:
undetectable		 4nedA-4yfaC:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 ASP A  91
VAL A 182
ALA A  33
PHE A  32
 CA  A 503 (-3.4A)
None
None
None
 1.16A 4nedA-4yweA:
undetectable		 4nedA-4yweA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		4 ASP A 437
ASP A 360
SER A 154
ALA A 271
 None
 1.22A 4nedA-5a2rA:
undetectable		 4nedA-5a2rA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8d CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43) 		4 ASP A 166
ASP A  43
SER A 268
ALA A 231
 None
 1.18A 4nedA-5a8dA:
undetectable		 4nedA-5a8dA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN

(Coprinopsis
cinerea) 		PF03664
(Glyco_hydro_62) 		4 VAL A 223
ASP A 224
SER A 124
PHE A 304
 GOL  A 502 (-4.0A)
GOL  A 502 (-3.0A)
GOL  A 502 ( 4.4A)
None
 1.14A 4nedA-5b6tA:
undetectable		 4nedA-5b6tA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		4 ASP A 355
VAL A 412
SER A 273
ALA A 162
 None
 1.06A 4nedA-5c9iA:
undetectable		 4nedA-5c9iA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlk TQAA

(Penicillium
aethiopicum) 		PF00668
(Condensation) 		4 VAL A 185
ASP A 183
ALA A  58
PHE A 331
 None
 1.02A 4nedA-5dlkA:
undetectable		 4nedA-5dlkA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 ASP A 820
VAL A 826
ASP A 827
ALA A 787
 None
 1.20A 4nedA-5e02A:
undetectable		 4nedA-5e02A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1q PERIPLASMIC
DIPEPTIDE TRANSPORT
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 ASP A 177
ASP A 441
SER A 449
PHE A 182
 None
 1.14A 4nedA-5f1qA:
4.9		 4nedA-5f1qA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6e ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		4 ASP A1316
ASP A1367
SER A 996
ALA A 920
 None
 1.15A 4nedA-5i6eA:
undetectable		 4nedA-5i6eA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME

(Brucella
melitensis) 		PF01053
(Cys_Met_Meta_PP) 		4 VAL A 212
SER A 259
ALA A 102
PHE A 104
 None
 1.22A 4nedA-5ijgA:
undetectable		 4nedA-5ijgA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv8 LPS BIOSYNTHESIS
PROTEIN

(Klebsiella
pneumoniae) 		PF04453
(OstA_C) 		4 ASP A 394
SER A 359
ALA A 389
PHE A 416
 None
 0.98A 4nedA-5iv8A:
undetectable		 4nedA-5iv8A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv9 LPS-ASSEMBLY PROTEIN
LPTD

(Klebsiella
pneumoniae) 		PF03968
(OstA)
PF04453
(OstA_C) 		4 ASP A 371
SER A 336
ALA A 366
PHE A 393
 None
 0.88A 4nedA-5iv9A:
undetectable		 4nedA-5iv9A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021

(Burkholderia
pseudomallei) 		PF00282
(Pyridoxal_deC) 		4 ASP A 233
ASP A 268
ALA A 161
PHE A 162
 PLP  A 501 (-2.6A)
PLP  A 501 (-3.6A)
PLP  A 501 ( 4.4A)
None
 1.20A 4nedA-5k1rA:
1.2		 4nedA-5k1rA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021

(Burkholderia
pseudomallei) 		PF00282
(Pyridoxal_deC) 		4 ASP A 233
ASP A 268
SER A 123
PHE A 162
 PLP  A 501 (-2.6A)
PLP  A 501 (-3.6A)
None
None
 1.20A 4nedA-5k1rA:
1.2		 4nedA-5k1rA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE

(Helicobacter
pylori) 		PF01048
(PNP_UDP_1) 		4 ASP A  90
VAL A  83
ASP A  85
ALA A 141
 None
 1.10A 4nedA-5k1zA:
undetectable		 4nedA-5k1zA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1

(Staphylococcus
aureus) 		no annotation 4 ASP B 256
ASP B 278
SER B  85
ALA B 172
 None
 1.12A 4nedA-5k59B:
undetectable		 4nedA-5k59B:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		4 ASP A 549
VAL A 453
ALA A 575
PHE A 574
 None
 1.08A 4nedA-5kqiA:
undetectable		 4nedA-5kqiA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER

(Prochlorococcus
marinus) 		no annotation 4 VAL A 179
SER A 126
ALA A  10
PHE A  23
 None
GB  A 401 (-2.6A)
None
None
 1.21A 4nedA-5lq8A:
10.4		 4nedA-5lq8A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnl LIGHT HARVESTING
CHLOROPHYLL
A/B-BINDING PROTEIN
LHCB5, CP26

(Pisum sativum) 		no annotation 4 VAL S  53
ASP S  56
SER S  65
ALA S  47
 None
CLA  S 602 (-4.0A)
CLA  S 602 ( 4.0A)
None
 1.14A 4nedA-5xnlS:
undetectable		 4nedA-5xnlS:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 4 ASP A 398
VAL A 384
SER A 671
PHE A 820
 None
 1.07A 4nedA-5xyaA:
undetectable		 4nedA-5xyaA:
undetectable