SIMILAR PATTERNS OF AMINO ACIDS FOR 4NC3_A_ERMA1202_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)

(Homo sapiens) 		PF00258
(Flavodoxin_1) 		4 THR A  30
ASN A 122
LEU A 143
GLU A 142
 FMN  A 190 (-3.5A)
None
None
None
 1.14A 4nc3A-1b1cA:
undetectable		 4nc3A-1b1cA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)

(Rattus
norvegicus) 		PF01239
(PPTA)
PF07711
(RabGGT_insert) 		4 THR A 387
LEU A 208
LEU A 356
GLU A 355
 None
 1.21A 4nc3A-1dceA:
3.2		 4nc3A-1dceA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji0 ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 LEU A 135
ASN A 100
LEU A 147
GLU A 143
 None
 1.16A 4nc3A-1ji0A:
undetectable		 4nc3A-1ji0A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 THR A 954
LEU A 925
GLN A  50
LEU A  49
 None
 1.08A 4nc3A-1jqoA:
2.2		 4nc3A-1jqoA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnt OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		4 LEU A 229
GLN A 234
LEU A 226
GLU A 225
 None
 1.17A 4nc3A-1nntA:
undetectable		 4nc3A-1nntA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT

(Paracoccus
denitrificans) 		no annotation 4 THR B 115
LEU B 149
LEU B 156
GLU B 168
 None
 1.23A 4nc3A-1pbyB:
undetectable		 4nc3A-1pbyB:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		4 LEU A 405
ASN A 160
LEU A 411
GLU A 413
 None
 1.18A 4nc3A-1qpgA:
undetectable		 4nc3A-1qpgA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri6 PUTATIVE ISOMERASE
YBHE

(Escherichia
coli) 		PF10282
(Lactonase) 		4 THR A  75
GLN A  96
LEU A 113
GLU A 114
 None
 1.25A 4nc3A-1ri6A:
undetectable		 4nc3A-1ri6A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 THR A  10
LEU A 474
LEU A 540
GLU A 539
 None
 1.14A 4nc3A-1sb3A:
undetectable		 4nc3A-1sb3A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snz ALDOSE 1-EPIMERASE

(Homo sapiens) 		PF01263
(Aldose_epim) 		4 THR A 335
LEU A  43
GLN A  23
LEU A  24
 None
 0.93A 4nc3A-1snzA:
undetectable		 4nc3A-1snzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7v MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 4

(Homo sapiens) 		PF03166
(MH2) 		4 LEU B 498
GLN B 410
LEU B 501
GLU B 526
 None
 1.10A 4nc3A-1u7vB:
undetectable		 4nc3A-1u7vB:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udq RIBONUCLEASE PH

(Aquifex
aeolicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 LEU A 248
GLN A 232
LEU A 231
GLU A 230
 None
 1.21A 4nc3A-1udqA:
undetectable		 4nc3A-1udqA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdw HYPOTHETICAL PROTEIN
PH1897

(Pyrococcus
horikoshii) 		PF00459
(Inositol_P) 		4 THR A 247
ASN A 240
LEU A 182
GLU A 178
 None
 1.21A 4nc3A-1vdwA:
undetectable		 4nc3A-1vdwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdy 2-5A-DEPENDENT
RIBONUCLEASE

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		4 THR A  94
LEU A 144
ASN A 119
LEU A 153
 None
 1.19A 4nc3A-1wdyA:
undetectable		 4nc3A-1wdyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xee CHEMOTAXIS-INHIBITIN
G PROTEIN CHIPS

(Staphylococcus
aureus) 		PF11434
(CHIPS) 		4 THR A  66
LEU A  80
LEU A  76
GLU A  60
 None
 1.25A 4nc3A-1xeeA:
undetectable		 4nc3A-1xeeA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A 125
ASN A 345
LEU A 135
GLU A 136
 None
 1.13A 4nc3A-1ys4A:
undetectable		 4nc3A-1ys4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl0 HYPOTHETICAL PROTEIN
PA5198

(Pseudomonas
aeruginosa) 		PF02016
(Peptidase_S66) 		4 LEU A  32
GLN A  38
LEU A  39
GLU A  40
 None
 1.11A 4nc3A-1zl0A:
undetectable		 4nc3A-1zl0A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afv COBALAMIN
BIOSYNTHESIS
PRECORRIN ISOMERASE

(Leptospira
interrogans) 		PF02570
(CbiC) 		4 ASN A 127
GLN A 155
LEU A 152
GLU A 150
 None
 1.26A 4nc3A-2afvA:
undetectable		 4nc3A-2afvA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 THR A 860
LEU A 816
LEU A 880
GLU A 875
 None
 0.97A 4nc3A-2b5mA:
undetectable		 4nc3A-2b5mA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE

(Pseudomonas
stutzeri) 		PF00202
(Aminotran_3) 		4 THR A 320
LEU A 275
LEU A  98
GLU A  99
 None
 1.23A 4nc3A-2cy8A:
undetectable		 4nc3A-2cy8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddh ACYL-COA OXIDASE

(Rattus
norvegicus) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		4 THR A  13
LEU A 335
GLN A 327
LEU A 322
 None
 1.22A 4nc3A-2ddhA:
2.7		 4nc3A-2ddhA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 4 THR A  89
LEU A  52
LEU A  49
GLU A  48
 None
None
GOL  A 507 ( 4.7A)
None
 0.97A 4nc3A-2de2A:
undetectable		 4nc3A-2de2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1k PREPHENATE
DEHYDROGENASE

(Synechocystis
sp. PCC 6803) 		PF02153
(PDH) 		4 THR A 215
LEU A 248
GLN A 242
LEU A 241
 None
 1.19A 4nc3A-2f1kA:
undetectable		 4nc3A-2f1kA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9b CALBINDIN

(Rattus
norvegicus) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		4 LEU A  43
GLN A  37
LEU A  36
GLU A  35
 None
 1.09A 4nc3A-2g9bA:
2.1		 4nc3A-2g9bA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 LEU A 613
ASN A 598
GLN A 643
LEU A 642
 None
 1.15A 4nc3A-2jgdA:
undetectable		 4nc3A-2jgdA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kki INTERLEUKIN-1 ALPHA

(Homo sapiens) 		PF00340
(IL1) 		4 THR A  69
GLN A  88
LEU A 142
GLU A  86
 None
 0.95A 4nc3A-2kkiA:
undetectable		 4nc3A-2kkiA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 LEU A 407
ASN A 419
GLN A 445
LEU A 444
 None
 1.14A 4nc3A-2okkA:
undetectable		 4nc3A-2okkA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qru UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF07859
(Abhydrolase_3) 		4 LEU A  79
ASN A  11
GLN A  84
LEU A  85
 None
 1.24A 4nc3A-2qruA:
undetectable		 4nc3A-2qruA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjg FERROUS IRON
TRANSPORT PROTEIN B
HOMOLOG

(Methanocaldococcus
jannaschii) 		PF02421
(FeoB_N) 		4 LEU A  98
ASN A  87
GLN A 103
LEU A 104
 None
 1.16A 4nc3A-2wjgA:
undetectable		 4nc3A-2wjgA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjg FERROUS IRON
TRANSPORT PROTEIN B
HOMOLOG

(Methanocaldococcus
jannaschii) 		PF02421
(FeoB_N) 		4 LEU A  98
ASN A  87
LEU A 104
GLU A 106
 None
 1.03A 4nc3A-2wjgA:
undetectable		 4nc3A-2wjgA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wji FERROUS IRON
TRANSPORT PROTEIN B
HOMOLOG

(Methanocaldococcus
jannaschii) 		PF02421
(FeoB_N) 		4 LEU A  98
ASN A  87
GLN A 103
LEU A 104
 None
 1.11A 4nc3A-2wjiA:
undetectable		 4nc3A-2wjiA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzm ALDO-KETO REDUCTASE

(Mycolicibacterium
smegmatis) 		PF00248
(Aldo_ket_red) 		4 THR A 271
LEU A 224
GLN A 230
LEU A 231
 None
 1.24A 4nc3A-2wzmA:
undetectable		 4nc3A-2wzmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 THR A 411
LEU A 354
ASN A 379
LEU A 350
 None
 1.13A 4nc3A-2z7xA:
undetectable		 4nc3A-2z7xA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 THR A 247
LEU A 367
GLN A 126
LEU A 125
 HEM  A1430 (-4.0A)
None
None
None
 1.10A 4nc3A-3abbA:
undetectable		 4nc3A-3abbA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brn LIPOCALIN

(Argas
monolakensis) 		PF02098
(His_binding) 		4 THR A  85
LEU A  50
ASN A  78
GLN A  14
 None
 0.91A 4nc3A-3brnA:
undetectable		 4nc3A-3brnA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byw PUTATIVE
ARABINOFURANOSYLTRAN
SFERASE

(Corynebacterium
diphtheriae) 		PF04602
(Arabinose_trans) 		4 THR A 134
GLN A  81
LEU A  77
GLU A 174
 None
 1.21A 4nc3A-3bywA:
undetectable		 4nc3A-3bywA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7j TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF00392
(GntR)
PF07729
(FCD) 		4 LEU A 195
ASN A 144
LEU A 131
GLU A 132
 None
NI  A 301 (-2.7A)
None
None
 1.21A 4nc3A-3c7jA:
undetectable		 4nc3A-3c7jA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3caw O-SUCCINYLBENZOATE
SYNTHASE

(Bdellovibrio
bacteriovorus) 		no annotation 4 THR A 323
GLN A  59
LEU A  60
GLU A  57
 None
 1.28A 4nc3A-3cawA:
undetectable		 4nc3A-3cawA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		4 THR A 407
LEU A 330
GLN A 336
LEU A 337
 None
 1.20A 4nc3A-3dm5A:
2.7		 4nc3A-3dm5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eg4 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Brucella suis) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		4 THR A  27
LEU A  39
LEU A   9
GLU A  10
 None
 1.27A 4nc3A-3eg4A:
undetectable		 4nc3A-3eg4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 GAMMA
CHAIN

(Escherichia
coli) 		PF02665
(Nitrate_red_gam) 		4 THR C 123
LEU C 197
GLN C 136
LEU C 133
 None
None
HEM  C 807 (-4.4A)
HEM  C 806 ( 4.8A)
 1.11A 4nc3A-3egwC:
3.1		 4nc3A-3egwC:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgt PUTATIVE
PHOSPHOLIPASE B-LIKE
2 28 KDA FORM
PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM

(Mus musculus) 		PF04916
(Phospholip_B) 		4 LEU B 276
ASN A  96
LEU A  94
GLU A 127
 None
 1.02A 4nc3A-3fgtB:
undetectable		 4nc3A-3fgtB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3d MATERNAL PROTEIN
PUMILIO

(Drosophila
melanogaster) 		PF00806
(PUF) 		4 LEU X 222
GLN X 183
LEU X 186
GLU X 187
 None
 1.05A 4nc3A-3h3dX:
undetectable		 4nc3A-3h3dX:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		4 THR A 257
LEU A 125
LEU A 281
GLU A 276
 None
 0.92A 4nc3A-3h6eA:
undetectable		 4nc3A-3h6eA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 110
LEU A  13
LEU A  16
GLU A  36
 None
 1.08A 4nc3A-3i6tA:
undetectable		 4nc3A-3i6tA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jys SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 THR A 521
LEU A 169
GLN A  89
LEU A  88
 None
 1.19A 4nc3A-3jysA:
1.9		 4nc3A-3jysA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdq UNCHARACTERIZED
CONSERVED PROTEIN

(Corynebacterium
diphtheriae) 		no annotation 4 LEU A  76
GLN A 151
LEU A 150
GLU A 149
 None
 0.85A 4nc3A-3kdqA:
3.9		 4nc3A-3kdqA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khn MOTB PROTEIN,
PUTATIVE

(Desulfovibrio
vulgaris) 		PF00691
(OmpA) 		4 THR A  72
LEU A 160
LEU A 130
GLU A 126
 None
 1.13A 4nc3A-3khnA:
undetectable		 4nc3A-3khnA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kny HYPOTHETICAL PROTEIN
BT_3535

(Bacteroides
thetaiotaomicron) 		no annotation 4 THR A  64
LEU A 204
ASN A  94
GLU A  87
 None
 1.15A 4nc3A-3knyA:
undetectable		 4nc3A-3knyA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS

(Streptomyces
sp. CK4412) 		PF00975
(Thioesterase) 		4 LEU A  11
ASN A 179
LEU A  19
GLU A  18
 None
 1.13A 4nc3A-3lcrA:
undetectable		 4nc3A-3lcrA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnm CURA

(Lyngbya
majuscula) 		PF05721
(PhyH) 		4 THR A 191
LEU A 262
GLN A 268
LEU A 269
 None
 1.20A 4nc3A-3nnmA:
undetectable		 4nc3A-3nnmA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00155
(Aminotran_1_2) 		4 THR A 231
LEU A 168
GLN A 153
LEU A 154
 None
 1.25A 4nc3A-3nraA:
undetectable		 4nc3A-3nraA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o38 SHORT CHAIN
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 THR A  91
LEU A  56
GLN A  62
LEU A  63
 None
 1.21A 4nc3A-3o38A:
undetectable		 4nc3A-3o38A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION

(Bifidobacterium
adolescentis) 		PF13556
(HTH_30) 		4 THR A 107
LEU A 137
GLN A 145
LEU A 144
 None
None
GOL  A 264 (-2.8A)
None
 1.05A 4nc3A-3onqA:
undetectable		 4nc3A-3onqA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 THR B 615
GLN B 554
LEU B 557
GLU B 558
 None
 0.95A 4nc3A-3p8cB:
1.7		 4nc3A-3p8cB:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgz SINGLE-STRANDED
DNA-BINDING PROTEIN

(Bartonella
henselae) 		PF00436
(SSB) 		4 THR A  36
LEU A  84
GLN A 105
LEU A 104
 None
 1.01A 4nc3A-3pgzA:
undetectable		 4nc3A-3pgzA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN L

(Human
gammaherpesvirus
4) 		no annotation 4 THR B  55
LEU B  83
LEU B 111
GLU B 112
 None
 1.25A 4nc3A-3phfB:
undetectable		 4nc3A-3phfB:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 THR A  39
LEU A 574
LEU A 581
GLU A 567
 None
 1.12A 4nc3A-3to3A:
3.3		 4nc3A-3to3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00180
(Iso_dh) 		4 THR A 353
LEU A  75
LEU A 313
GLU A 314
 None
 1.09A 4nc3A-3ty4A:
1.8		 4nc3A-3ty4A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 THR A 233
LEU A  46
ASN A 191
LEU A 169
 None
 1.24A 4nc3A-3w6qA:
undetectable		 4nc3A-3w6qA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		4 THR A 847
LEU A 656
LEU A 793
GLU A 792
 None
 0.72A 4nc3A-3welA:
undetectable		 4nc3A-3welA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zig SEPF-LIKE PROTEIN

(Pyrococcus
furiosus) 		PF04472
(SepF) 		4 THR A 101
LEU A  81
LEU A  90
GLU A  89
 None
 1.16A 4nc3A-3zigA:
undetectable		 4nc3A-3zigA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE

(Pseudomonas
aeruginosa) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 THR A 115
LEU A 247
GLN A 272
LEU A 271
 ANP  A1456 (-3.6A)
None
None
None
 1.11A 4nc3A-4cvmA:
undetectable		 4nc3A-4cvmA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eg9 UNCHARACTERIZED
PROTEIN
SAOUHSC_02783

(Staphylococcus
aureus) 		PF04507
(DUF576) 		4 THR A  43
LEU A 216
GLN A 190
LEU A 191
 None
 1.24A 4nc3A-4eg9A:
undetectable		 4nc3A-4eg9A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evf GIARDIN SUBUNIT
ALPHA-1

(Giardia
intestinalis) 		PF00191
(Annexin) 		4 THR A 207
LEU A 162
ASN A 197
GLU A 191
 None
 1.18A 4nc3A-4evfA:
undetectable		 4nc3A-4evfA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gct NUCLEOID OCCLUSION
FACTOR SLMA

(Vibrio cholerae) 		PF00440
(TetR_N) 		4 THR A 181
LEU A  68
LEU A 134
GLU A 131
 None
 1.04A 4nc3A-4gctA:
3.1		 4nc3A-4gctA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1

(Homo sapiens) 		PF13181
(TPR_8)
PF13424
(TPR_12) 		4 LEU A  57
ASN A 100
LEU A  75
GLU A  77
 None
 1.22A 4nc3A-4houA:
undetectable		 4nc3A-4houA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1d ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF13416
(SBP_bac_8) 		4 THR A 271
ASN A 246
GLN A 327
GLU A 331
 None
 1.23A 4nc3A-4i1dA:
undetectable		 4nc3A-4i1dA:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 LEU A 209
ASN A 344
GLN A 359
LEU A 362
GLU A 363
 ERM  A2001 (-3.7A)
ERM  A2001 (-4.3A)
None
ERM  A2001 ( 4.1A)
ERM  A2001 ( 4.5A)
 0.65A 4nc3A-4ib4A:
46.7		 4nc3A-4ib4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 THR A 140
LEU A 209
ASN A 344
GLN A 359
LEU A 362
 ERM  A2001 (-3.9A)
ERM  A2001 (-3.7A)
ERM  A2001 (-4.3A)
None
ERM  A2001 ( 4.1A)
 0.21A 4nc3A-4ib4A:
46.7		 4nc3A-4ib4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		4 LEU A 186
ASN A  36
GLN A 111
LEU A 114
 None
 1.17A 4nc3A-4ifqA:
2.1		 4nc3A-4ifqA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 THR A 633
ASN A 495
GLN A 617
LEU A 624
 None
 1.21A 4nc3A-4n3sA:
undetectable		 4nc3A-4n3sA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B

(Streptococcus
thermophilus) 		PF02421
(FeoB_N) 		4 LEU A  95
ASN A  84
GLN A 100
LEU A 101
 LEU  A  95 ( 0.6A)
ASN  A  84 ( 0.6A)
GLN  A 100 ( 0.6A)
LEU  A 101 ( 0.6A)
 1.27A 4nc3A-4nonA:
undetectable		 4nc3A-4nonA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 THR B  94
LEU B 144
ASN B 119
LEU B 153
 None
 1.20A 4nc3A-4oavB:
undetectable		 4nc3A-4oavB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		4 THR A 270
LEU A 223
GLN A 229
LEU A 230
 None
 1.24A 4nc3A-4otkA:
undetectable		 4nc3A-4otkA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q00 FERROUS IRON
TRANSPORT PROTEIN B

(Escherichia
coli) 		PF02421
(FeoB_N) 		4 LEU A 102
ASN A  91
GLN A 107
LEU A 108
 None
 1.10A 4nc3A-4q00A:
undetectable		 4nc3A-4q00A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq1 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 THR A 170
LEU A 198
LEU A 186
GLU A 203
 None
 1.16A 4nc3A-4qq1A:
undetectable		 4nc3A-4qq1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		4 THR A 459
LEU A 397
LEU A 437
GLU A 434
 None
 1.28A 4nc3A-4u48A:
undetectable		 4nc3A-4u48A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7h CARBONYL REDUCTASE

(Sphingomonas
sp. A1) 		PF13561
(adh_short_C2) 		4 THR A 148
ASN A  37
GLN A  74
LEU A  75
 None
 1.07A 4nc3A-4w7hA:
undetectable		 4nc3A-4w7hA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 LEU A 235
ASN A 205
LEU A 197
GLU A 177
 None
 1.08A 4nc3A-4xixA:
undetectable		 4nc3A-4xixA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Thermotoga
maritima) 		PF01867
(Cas_Cas1) 		4 THR A 216
LEU A 309
LEU A 302
GLU A 301
 None
 1.03A 4nc3A-4xtkA:
undetectable		 4nc3A-4xtkA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5z GLUTAMYL-TRNA
AMIDOTRANSFERASE

(Escherichia
coli) 		no annotation 4 LEU A 101
ASN A   9
LEU A  41
GLU A 112
 None
 1.21A 4nc3A-5c5zA:
undetectable		 4nc3A-5c5zA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2

(Homo sapiens) 		no annotation 4 THR I 752
LEU I 667
GLN I 652
LEU I 653
 None
 0.96A 4nc3A-5furI:
undetectable		 4nc3A-5furI:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5il7 RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF12799
(LRR_4)
PF13516
(LRR_6) 		4 LEU A 202
GLN A 245
LEU A 244
GLU A 243
 None
 1.00A 4nc3A-5il7A:
undetectable		 4nc3A-5il7A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2

(Homo sapiens) 		PF05609
(LAP1C) 		4 THR B 397
LEU B 281
LEU B 262
GLU B 263
 None
 1.11A 4nc3A-5j1sB:
undetectable		 4nc3A-5j1sB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd9 SPORE COAT PROTEIN H

(Bacillus cereus) 		PF08757
(CotH) 		4 ASN A  76
GLN A 121
LEU A 122
GLU A 123
 None
EDO  A 405 (-3.7A)
None
EDO  A 405 (-4.9A)
 1.26A 4nc3A-5jd9A:
undetectable		 4nc3A-5jd9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF03971
(IDH) 		4 LEU A 666
GLN A 672
LEU A 694
GLU A 698
 None
 1.11A 4nc3A-5kvuA:
5.5		 4nc3A-5kvuA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 4 LEU A 719
ASN A 756
LEU A 784
GLU A 783
 None
None
None
MLY  A 779 ( 2.9A)
 1.23A 4nc3A-5mhfA:
2.8		 4nc3A-5mhfA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz6 SEPARASE

(Caenorhabditis
elegans) 		PF03568
(Peptidase_C50) 		4 LEU 1  44
GLN 1  38
LEU 1  37
GLU 1  36
 None
 1.28A 4nc3A-5mz61:
undetectable		 4nc3A-5mz61:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 10
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 19

(Schizosaccharomyces
pombe) 		PF08633
(Rox3)
PF08638
(Med14)
PF09748
(Med10) 		4 THR C  33
ASN B  98
GLN A  90
LEU A  87
 None
 0.74A 4nc3A-5n9jC:
undetectable		 4nc3A-5n9jC:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio rerio;
Escherichia
coli) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 THR A1313
GLN A1122
LEU A1120
GLU A1121
 None
 0.87A 4nc3A-5t03A:
undetectable		 4nc3A-5t03A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 THR A 614
LEU A 487
LEU A 461
GLU A 462
 None
 0.78A 4nc3A-5t88A:
undetectable		 4nc3A-5t88A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xaz GAMMA-BUTYROLACTONE
RECEPTOR PROTEIN

(Streptomyces
fradiae) 		PF00440
(TetR_N) 		4 THR A  85
GLN A  58
LEU A  61
GLU A  59
 None
 0.95A 4nc3A-5xazA:
4.8		 4nc3A-5xazA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ba5 VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11

(Homo sapiens) 		no annotation 4 THR A 106
LEU A  34
GLN A  28
GLU A   2
 None
 1.26A 4nc3A-6ba5A:
undetectable		 4nc3A-6ba5A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 4 THR B 583
GLN B 677
LEU B 556
GLU B 555
 None
 1.07A 4nc3A-6btmB:
undetectable		 4nc3A-6btmB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1

(Homo sapiens) 		no annotation 4 LEU A  59
ASN A 102
LEU A  77
GLU A  79
 None
 1.17A 4nc3A-6c6kA:
undetectable		 4nc3A-6c6kA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dg4 ULP1-LIKE SUMO
PROTEASE

(Chaetomium
thermophilum) 		no annotation 4 LEU A  39
GLN A  42
LEU A  44
GLU A  34
 None
 0.87A 4nc3A-6dg4A:
undetectable		 4nc3A-6dg4A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo sapiens) 		no annotation 4 THR A 402
GLN A 582
LEU A 581
GLU A 585
 None
 1.08A 4nc3A-6etiA:
undetectable		 4nc3A-6etiA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 4 THR B 215
LEU B 204
LEU B 497
GLU B 498
 None
 1.18A 4nc3A-6f0kB:
undetectable		 4nc3A-6f0kB:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea NITROGENASE PROTEIN
ALPHA CHAIN

(Azotobacter
vinelandii) 		no annotation 4 LEU A 244
ASN A 206
LEU A 268
GLU A 267
 None
 1.21A 4nc3A-6feaA:
undetectable		 4nc3A-6feaA:
13.95