SIMILAR PATTERNS OF AMINO ACIDS FOR 4N49_A_SAMA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a88 CHLOROPEROXIDASE L

(Streptomyces
lividans) 		PF00561
(Abhydrolase_1) 		4 ASN A 169
GLY A 167
ASP A 233
ASP A 225
 None
 1.21A 4n49A-1a88A:
2.2		 4n49A-1a88A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8q BROMOPEROXIDASE A1

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		4 ASN A 166
GLY A 161
ASP A 133
ASP A 222
 None
 1.26A 4n49A-1a8qA:
1.7		 4n49A-1a8qA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 ASN A 182
GLY A 174
ASP A 101
ASP A 215
 FMN  A 751 (-4.9A)
FMN  A 751 (-3.2A)
None
None
 1.12A 4n49A-1amoA:
2.8		 4n49A-1amoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)

(Homo sapiens) 		PF00258
(Flavodoxin_1) 		4 ASN A 122
GLY A 114
ASP A  41
ASP A 155
 None
FMN  A 190 (-3.2A)
None
None
 1.07A 4n49A-1b1cA:
undetectable		 4n49A-1b1cA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		4 ASN A 106
GLY A  97
ASP A 248
ASP A 334
 None
 1.40A 4n49A-1cvrA:
1.6		 4n49A-1cvrA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 ASN A 361
GLY A 362
ASP A 290
ASP A 365
 None
None
None
XYP  A1719 (-3.3A)
 1.35A 4n49A-1gqjA:
undetectable		 4n49A-1gqjA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 ASN A 208
GLY A 211
ASP A 267
ASP A 411
 None
 1.41A 4n49A-1h54A:
undetectable		 4n49A-1h54A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ASN A 100
GLY A 104
ASP A 124
ASP A  97
 None
 1.14A 4n49A-1m53A:
1.1		 4n49A-1m53A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 ASN A 360
GLY A 361
ASP A 283
ASP A 364
 None
None
None
GCU  A 701 ( 2.3A)
 1.35A 4n49A-1mqqA:
undetectable		 4n49A-1mqqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3d SERINE
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		4 ASN A 261
GLY A 262
ASP A 157
ASP A 257
 None
 1.28A 4n49A-1t3dA:
undetectable		 4n49A-1t3dA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		4 ASN A 174
GLY A 391
ASP A 285
ASP A  71
 None
 1.25A 4n49A-1t6pA:
undetectable		 4n49A-1t6pA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnd TRANSDUCIN

(Bos taurus) 		PF00503
(G-alpha) 		4 ASN A 265
GLY A  41
ASP A 154
ASP A 146
 GSP  A 351 (-3.2A)
GSP  A 351 (-3.3A)
None
GSP  A 351 (-3.3A)
 1.31A 4n49A-1tndA:
undetectable		 4n49A-1tndA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un1 XYLOGLUCAN
ENDOTRANSGLYCOSYLASE

(Populus tremula) 		PF00722
(Glyco_hydro_16)
PF06955
(XET_C) 		4 ASN A 175
GLY A  69
ASP A 112
ASP A 178
 None
 1.37A 4n49A-1un1A:
undetectable		 4n49A-1un1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		4 ASN A 336
GLY A 328
ASP A  29
ASP A 370
 None
None
None
CA  A1398 (-2.9A)
 1.16A 4n49A-1ur4A:
undetectable		 4n49A-1ur4A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8a SLIT PROTEIN

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 ASN A 580
GLY A 558
ASP A 542
ASP A 555
 None
 1.28A 4n49A-1w8aA:
undetectable		 4n49A-1w8aA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Helicobacter
pylori) 		PF02540
(NAD_synthase) 		4 ASN A 154
GLY A 157
ASP A 195
ASP A  37
 None
None
None
ATP  A 303 (-3.9A)
 1.24A 4n49A-1xngA:
undetectable		 4n49A-1xngA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		4 ASN A 672
GLY A 675
ASP A 313
ASP A 136
 None
 0.82A 4n49A-1z26A:
undetectable		 4n49A-1z26A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE

([Candida]
tenuis) 		PF00248
(Aldo_ket_red) 		4 ASN A  28
GLY A  53
ASP A 109
ASP A 102
 None
 1.09A 4n49A-1z9aA:
undetectable		 4n49A-1z9aA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE

(Sulfurisphaera
tokodaii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ASN A 328
GLY A 329
ASP A 112
ASP A 245
 None
 1.06A 4n49A-2f7lA:
undetectable		 4n49A-2f7lA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm8 CELL INVASION
PROTEIN SIPA

(Salmonella
enterica) 		PF09052
(SipA) 		4 ASN C  85
GLY C  88
ASP C  72
ASP C 130
 None
 1.28A 4n49A-2fm8C:
undetectable		 4n49A-2fm8C:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm9 CELL INVASION
PROTEIN SIPA

(Salmonella
enterica) 		PF09052
(SipA) 		4 ASN A  85
GLY A  88
ASP A  72
ASP A 130
 None
 1.26A 4n49A-2fm9A:
undetectable		 4n49A-2fm9A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 ASN A 637
GLY A 431
ASP A 299
ASP A 309
 None
 1.40A 4n49A-2fuqA:
undetectable		 4n49A-2fuqA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ASN A 161
GLY A 163
ASP A 175
ASP A 166
 None
 1.17A 4n49A-2fuvA:
undetectable		 4n49A-2fuvA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ASN A 518
GLY A 491
ASP A 481
ASP A 488
 None
 1.16A 4n49A-2gv9A:
undetectable		 4n49A-2gv9A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk7 SHIKIMATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ASN A  64
GLY A 243
ASP A  82
ASP A 106
 None
 1.23A 4n49A-2hk7A:
4.2		 4n49A-2hk7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		4 ASN A 360
GLY A 325
ASP A 371
ASP A 397
 None
 1.16A 4n49A-2hmfA:
undetectable		 4n49A-2hmfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz7 GLUTAMINYL-TRNA
SYNTHETASE

(Deinococcus
radiodurans) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 ASN A 236
GLY A 204
ASP A 142
ASP A 244
 None
 1.10A 4n49A-2hz7A:
undetectable		 4n49A-2hz7A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT

(Homo sapiens) 		PF00503
(G-alpha) 		4 ASN A 269
GLY A  45
ASP A 158
ASP A 150
 GDP  A 401 (-3.1A)
GDP  A 401 (-3.3A)
None
None
 1.12A 4n49A-2ik8A:
undetectable		 4n49A-2ik8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ASN A 298
GLY A  62
ASP A  81
ASP A  87
 None
 1.13A 4n49A-2isaA:
undetectable		 4n49A-2isaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 ASN A1702
GLY A1545
ASP A1927
ASP A1920
 None
 1.37A 4n49A-2ix8A:
undetectable		 4n49A-2ix8A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE

(Escherichia
coli) 		PF01204
(Trehalase) 		4 ASN A 196
GLY A 197
ASP A 516
ASP A 160
 VDM  A1548 (-2.9A)
None
None
VDM  A1548 (-3.0A)
 1.39A 4n49A-2jf4A:
undetectable		 4n49A-2jf4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		4 ASN A 295
GLY A 294
ASP A  45
ASP A 344
 None
 1.12A 4n49A-2w61A:
undetectable		 4n49A-2w61A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wte CSA3

(Sulfolobus
solfataricus) 		no annotation 4 ASN A 101
GLY A  96
ASP A  28
ASP A  92
 None
 1.25A 4n49A-2wteA:
2.8		 4n49A-2wteA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x50 TRYPANOTHIONE
REDUCTASE

(Leishmania
infantum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASN A 208
GLY A 246
ASP A  84
ASP A  71
 None
 1.39A 4n49A-2x50A:
undetectable		 4n49A-2x50A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Homo sapiens) 		PF05645
(RNA_pol_Rpc82)
PF08221
(HTH_9) 		4 ASN A 291
GLY A 330
ASP A 318
ASP A 309
 None
 1.18A 4n49A-2xubA:
undetectable		 4n49A-2xubA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Homo sapiens) 		PF05645
(RNA_pol_Rpc82)
PF08221
(HTH_9) 		4 ASN A 291
GLY A 331
ASP A 318
ASP A 309
 None
 1.00A 4n49A-2xubA:
undetectable		 4n49A-2xubA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yil MICRONEME ANTIGEN L2

(Sarcocystis
muris) 		PF00024
(PAN_1)
PF14295
(PAN_4) 		4 ASN A  52
GLY A  70
ASP A   6
ASP A  13
 None
None
None
GOL  A1137 (-4.1A)
 1.29A 4n49A-2yilA:
undetectable		 4n49A-2yilA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 4 ASN A 208
GLY A 238
ASP A 153
ASP A 187
 None
RAM  A 642 (-3.5A)
CA  A 630 (-2.8A)
RAM  A 641 (-2.7A)
 1.42A 4n49A-2zuxA:
undetectable		 4n49A-2zuxA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		4 ASN A 930
GLY A 925
ASP A 468
ASP A 937
 None
 1.26A 4n49A-3aibA:
undetectable		 4n49A-3aibA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db7 PUTATIVE
CALCIUM-REGULATED
PERIPLASMIC PROTEIN

(Bacteroides
thetaiotaomicron) 		PF11396
(PepSY_like) 		4 ASN A  68
GLY A  69
ASP A  75
ASP A  84
 None
 1.42A 4n49A-3db7A:
undetectable		 4n49A-3db7A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		4 ASN X   9
GLY X  12
ASP X 226
ASP X 344
 None
 1.23A 4n49A-3dwoX:
undetectable		 4n49A-3dwoX:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR

(Bordetella
pertussis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASN A 116
GLY A 118
ASP A 203
ASP A  69
 None
 1.38A 4n49A-3efmA:
undetectable		 4n49A-3efmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ASN A  73
GLY A  77
ASP A  97
ASP A  70
 None
 1.23A 4n49A-3gbdA:
1.1		 4n49A-3gbdA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdo UNCHARACTERIZED
OXIDOREDUCTASE YVAA

(Bacillus
subtilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ASN A 307
GLY A 280
ASP A  37
ASP A 276
 None
 1.39A 4n49A-3gdoA:
3.1		 4n49A-3gdoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ge4 DNA PROTECTION
DURING STARVATION
PROTEIN

(Brucella
melitensis) 		PF00210
(Ferritin) 		4 ASN A 123
GLY A 119
ASP A  68
ASP A 152
 None
 1.37A 4n49A-3ge4A:
undetectable		 4n49A-3ge4A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv4 GLYCOSIDE HYDROLASE
YXIA

(Bacillus
licheniformis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 ASN A 304
GLY A 303
ASP A 290
ASP A 392
 None
 1.29A 4n49A-3lv4A:
undetectable		 4n49A-3lv4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg9 TEG12

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		4 ASN A   2
GLY A   3
ASP A 195
ASP A 186
 None
 1.36A 4n49A-3mg9A:
undetectable		 4n49A-3mg9A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 ASN A 243
GLY A  98
ASP A 110
ASP A 102
 None
 1.10A 4n49A-3ml5A:
undetectable		 4n49A-3ml5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		4 ASN A  31
GLY A  80
ASP A 168
ASP A  26
 None
None
ATP  A 763 ( 4.7A)
None
 1.18A 4n49A-3o8lA:
undetectable		 4n49A-3o8lA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oy2 GLYCOSYLTRANSFERASE
B736L

(Paramecium
bursaria
Chlorella virus
NY2A) 		no annotation 4 ASN A  96
GLY A  95
ASP A 330
ASP A  90
 None
 1.22A 4n49A-3oy2A:
2.5		 4n49A-3oy2A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyw S-LAYER PROTEIN SAP

(Bacillus
anthracis) 		PF00395
(SLH) 		4 ASN A  30
GLY A  33
ASP A  16
ASP A   7
 None
None
SO4  A 204 (-3.9A)
None
 1.32A 4n49A-3pywA:
undetectable		 4n49A-3pywA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r79 UNCHARACTERIZED
PROTEIN

(Agrobacterium
fabrum) 		PF01168
(Ala_racemase_N) 		4 ASN A 171
GLY A 173
ASP A  17
ASP A 198
 None
 1.11A 4n49A-3r79A:
undetectable		 4n49A-3r79A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		4 ASN A 240
GLY A  17
ASP A 137
ASP A  11
 MN  A 365 (-2.6A)
None
None
None
 1.32A 4n49A-3rmjA:
undetectable		 4n49A-3rmjA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		4 ASN A 390
GLY A 393
ASP A 349
ASP A  49
 None
 1.33A 4n49A-3tqoA:
undetectable		 4n49A-3tqoA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4y UNCHARACTERIZED
PROTEIN

(Desulfotomaculum
acetoxidans) 		PF10282
(Lactonase) 		4 ASN A 177
GLY A 129
ASP A  92
ASP A  41
 None
 1.07A 4n49A-3u4yA:
undetectable		 4n49A-3u4yA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		4 ASN A 383
GLY A 402
ASP A 411
ASP A 405
 None
 1.41A 4n49A-3ut2A:
undetectable		 4n49A-3ut2A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 ASN A 492
GLY A 491
ASP A 190
ASP A 232
 PO4  A1728 ( 2.5A)
None
None
MG  A1732 (-1.9A)
 1.15A 4n49A-4av6A:
undetectable		 4n49A-4av6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens;
Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		4 ASN B 371
GLY B 382
ASP A 554
ASP A 560
 NAG  B3371 (-1.9A)
None
None
None
 1.37A 4n49A-4cakB:
undetectable		 4n49A-4cakB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ekd GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(Q) SUBUNIT
ALPHA

(Mus musculus) 		PF00503
(G-alpha) 		4 ASN A 274
GLY A  51
ASP A 163
ASP A 155
 GDP  A 401 (-3.5A)
GDP  A 401 (-3.2A)
None
GDP  A 401 ( 4.8A)
 1.09A 4n49A-4ekdA:
undetectable		 4n49A-4ekdA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Plasmodium
falciparum) 		PF00156
(Pribosyltran) 		4 ASN A 104
GLY A 101
ASP A 276
ASP A 209
 None
 1.18A 4n49A-4fymA:
undetectable		 4n49A-4fymA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Archaeoglobus
fulgidus) 		PF02289
(MCH) 		4 ASN A  31
GLY A  32
ASP A 130
ASP A 160
 None
 1.40A 4n49A-4gvrA:
undetectable		 4n49A-4gvrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Yersinia pestis) 		PF01513
(NAD_kinase) 		4 ASN A  97
GLY A  96
ASP A 115
ASP A 107
 None
 1.30A 4n49A-4haoA:
undetectable		 4n49A-4haoA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB

(Pseudomonas
aeruginosa) 		PF13360
(PQQ_2) 		4 ASN A 145
GLY A 146
ASP A 117
ASP A 162
 None
 1.40A 4n49A-4hdjA:
undetectable		 4n49A-4hdjA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ASN A 100
GLY A 104
ASP A 124
ASP A  97
 None
 1.18A 4n49A-4hozA:
undetectable		 4n49A-4hozA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		4 ASN A 213
GLY A 495
ASP A 262
ASP A 189
 None
 0.78A 4n49A-4hwvA:
undetectable		 4n49A-4hwvA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4i 6-PHOSPHOFRUCTOKINAS
E

(Geobacillus
stearothermophilus) 		PF00365
(PFK) 		4 ASN A  17
GLY A  64
ASP A 129
ASP A  12
 None
 0.94A 4n49A-4i4iA:
undetectable		 4n49A-4i4iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASN A 317
GLY A 309
ASP A 247
ASP A 293
 None
None
None
4OP  A 416 ( 4.8A)
 1.02A 4n49A-4izgA:
undetectable		 4n49A-4izgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ASN A 317
GLY A 318
ASP A 382
ASP A 283
 None
 1.20A 4n49A-4l7tA:
undetectable		 4n49A-4l7tA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llf CAPSID PROTEIN

(Cucumber
necrosis virus) 		PF00729
(Viral_coat) 		4 ASN A 115
GLY A 232
ASP A 222
ASP A 178
 None
 1.08A 4n49A-4llfA:
undetectable		 4n49A-4llfA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ASN A 334
GLY A 307
ASP A 184
ASP A 330
 None
 1.26A 4n49A-4n14A:
undetectable		 4n49A-4n14A:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		4 ASN A 234
GLY A 282
ASP A 335
ASP A 364
 SAM  A 601 (-3.3A)
SAM  A 601 (-3.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
 0.01A 4n49A-4n49A:
73.4		 4n49A-4n49A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ASN A  99
GLY A 103
ASP A  68
ASP A 107
 None
 1.29A 4n49A-4o9xA:
undetectable		 4n49A-4o9xA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS

(Escherichia
coli) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 ASN A 248
GLY A 251
ASP A  72
ASP A 132
 None
 1.25A 4n49A-4pdxA:
undetectable		 4n49A-4pdxA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2b ENDO-1,4-BETA-D-GLUC
ANASE

(Pseudomonas
putida) 		PF01270
(Glyco_hydro_8) 		4 ASN A 113
GLY A 166
ASP A 189
ASP A 116
 None
None
None
TRS  A 402 (-2.8A)
 1.23A 4n49A-4q2bA:
undetectable		 4n49A-4q2bA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE

(Homo sapiens) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASN A 455
GLY A 438
ASP A 112
ASP A 441
 None
 1.11A 4n49A-4ruhA:
undetectable		 4n49A-4ruhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides) 		PF02324
(Glyco_hydro_70) 		4 ASN A1946
GLY A1933
ASP A1888
ASP A1960
 None
 1.20A 4n49A-4tvcA:
undetectable		 4n49A-4tvcA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		4 ASN A  74
GLY A  54
ASP A 135
ASP A  13
 DDZ  A  53 ( 4.2A)
DDZ  A  53 ( 2.4A)
None
ZN  A1576 (-2.1A)
 1.06A 4n49A-4upiA:
undetectable		 4n49A-4upiA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus AP22) 		no annotation 4 ASN A 441
GLY A 407
ASP A 448
ASP A 437
 49S  A 814 (-3.6A)
49S  A 814 (-3.5A)
None
SO4  A 809 ( 4.7A)
 1.12A 4n49A-4y9vA:
undetectable		 4n49A-4y9vA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzt CELLULOSE HYDROLASE

(Bacillus
licheniformis) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		4 ASN A 361
GLY A 418
ASP A 340
ASP A 285
 None
 1.39A 4n49A-4yztA:
undetectable		 4n49A-4yztA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Streptobacillus
moniliformis) 		PF13407
(Peripla_BP_4) 		4 ASN A  39
GLY A 238
ASP A  94
ASP A 209
 None
 1.30A 4n49A-4z0nA:
undetectable		 4n49A-4z0nA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		4 ASN A 204
GLY A 203
ASP A 230
ASP A 240
 None
 1.37A 4n49A-4zzqA:
undetectable		 4n49A-4zzqA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		4 ASN A 136
GLY A 135
ASP A1137
ASP A1285
 None
 1.37A 4n49A-5a22A:
16.5		 4n49A-5a22A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		4 ASN A 259
GLY A 318
ASP A 350
ASP A 375
 GAL  A 701 (-4.0A)
None
None
None
 1.33A 4n49A-5bxpA:
undetectable		 4n49A-5bxpA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c69 FUSION GLYCOPROTEIN
F0,FIBRITIN

(Enterobacteria
phage Ox2;
Human
orthopneumovirus) 		PF00523
(Fusion_gly) 		4 ASN A 410
GLY A 411
ASP A 452
ASP A 374
 None
 1.42A 4n49A-5c69A:
undetectable		 4n49A-5c69A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ASN A 510
GLY A 482
ASP A 329
ASP A 385
 None
 1.38A 4n49A-5dmyA:
undetectable		 4n49A-5dmyA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF04453
(OstA_C)
PF04390
(LptE) 		4 ASN B 114
GLY B 117
ASP A 398
ASP A 394
 None
 1.18A 4n49A-5ivaB:
undetectable		 4n49A-5ivaB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j04 ENOLASE

(Synechococcus
elongatus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ASN A 162
GLY A 156
ASP A 276
ASP A 165
 None
 1.03A 4n49A-5j04A:
undetectable		 4n49A-5j04A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans) 		PF03055
(RPE65) 		4 ASN A 287
GLY A 363
ASP A 427
ASP A 359
 None
 1.23A 4n49A-5j55A:
undetectable		 4n49A-5j55A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbe INACTIVE
GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF02324
(Glyco_hydro_70) 		4 ASN A1287
GLY A1289
ASP A1380
ASP A1254
 None
 1.14A 4n49A-5jbeA:
undetectable		 4n49A-5jbeA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk7 PROTEIN VPRBP

(Homo sapiens) 		no annotation 4 ASN C1269
GLY C1270
ASP C1256
ASP C1281
 None
 1.31A 4n49A-5jk7C:
undetectable		 4n49A-5jk7C:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Acidaminococcus
sp. BV3L6) 		no annotation 4 ASN A1122
GLY A1100
ASP A1107
ASP A1102
 None
 1.13A 4n49A-5kk5A:
undetectable		 4n49A-5kk5A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 4 ASN A1125
GLY A1126
ASP A 680
ASP A1178
 None
 1.40A 4n49A-5ngyA:
undetectable		 4n49A-5ngyA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxn PORIN 1

(Providencia
stuartii) 		no annotation 4 ASN A 284
GLY A 115
ASP A  34
ASP A 321
 None
 1.07A 4n49A-5nxnA:
undetectable		 4n49A-5nxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		4 ASN A 248
GLY A 161
ASP A 104
ASP A 275
 None
 1.13A 4n49A-5u24A:
undetectable		 4n49A-5u24A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjw RHIZOBIALES-LIKE
PHOSPHATASE 2

(Arabidopsis
thaliana) 		no annotation 4 ASN A  80
GLY A  79
ASP A 287
ASP A  50
 WO4  A 403 ( 2.3A)
None
None
None
 1.38A 4n49A-5vjwA:
undetectable		 4n49A-5vjwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN

(Shewanella
loihica) 		no annotation 4 ASN A 103
GLY A 134
ASP A 159
ASP A 132
 None
 1.31A 4n49A-5x8zA:
undetectable		 4n49A-5x8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 4 ASN A 591
GLY A 594
ASP A 667
ASP A 624
 None
 1.28A 4n49A-5z06A:
undetectable		 4n49A-5z06A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ape BIFUNCTIONAL PROTEIN
FOLD

(Helicobacter
pylori) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 ASN A 236
GLY A 245
ASP A 198
ASP A 217
 GOL  A 303 ( 4.6A)
None
None
None
 1.26A 4n49A-6apeA:
undetectable		 4n49A-6apeA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 4 ASN B 187
GLY B 102
ASP B 145
ASP B 566
 None
 1.22A 4n49A-6btmB:
undetectable		 4n49A-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 4 ASN A 728
GLY A 803
ASP A 832
ASP A 722
 MGD  A 902 (-4.8A)
None
None
MGD  A 903 ( 2.1A)
 1.36A 4n49A-6czaA:
undetectable		 4n49A-6czaA:
undetectable