SIMILAR PATTERNS OF AMINO ACIDS FOR 4N48_B_SAMB601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 GLY A 563
PHE A 565
THR A 204
GLY A 492
LEU A 241
 None
 1.19A 4n48B-1ciyA:
undetectable		 4n48B-1ciyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geu GLUTATHIONE
REDUCTASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 132
GLY A 297
ILE A 285
THR A 279
LEU A 272
 None
 1.02A 4n48B-1geuA:
undetectable		 4n48B-1geuA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00117
(GATase) 		5 ALA H  18
GLY H  48
GLY H  13
GLY H  80
LEU H  88
 None
 1.15A 4n48B-1ka9H:
undetectable		 4n48B-1ka9H:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		5 GLY A 409
GLY A 322
THR A  44
GLY A  22
LEU A 414
 None
 1.23A 4n48B-1kfwA:
undetectable		 4n48B-1kfwA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks8 ENDO-B-1,4-GLUCANASE

(Nasutitermes
takasagoensis) 		PF00759
(Glyco_hydro_9) 		5 ALA A 202
GLY A 115
GLY A  62
PHE A  61
GLY A 118
 None
 1.12A 4n48B-1ks8A:
undetectable		 4n48B-1ks8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 GLY A 240
GLY A 182
THR A 277
ASN A 261
GLY A 258
 None
None
None
CA  A 702 (-3.1A)
None
 1.08A 4n48B-1lrwA:
undetectable		 4n48B-1lrwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		5 ALA B 245
GLY B 149
PHE B 150
THR B 137
ILE B 135
 None
 0.97A 4n48B-1mioB:
undetectable		 4n48B-1mioB:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE

(Haemophilus
influenzae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 GLY A  27
GLY A  25
PHE A  23
THR A 130
GLY A  33
 EPU  A 598 (-3.7A)
EPU  A 598 (-3.5A)
None
None
None
 1.10A 4n48B-1p31A:
undetectable		 4n48B-1p31A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pek PROTEINASE K

(Parengyodontium
album) 		PF00082
(Peptidase_S8) 		5 GLY E  75
GLY E  78
THR E 211
ILE E 213
GLY E  70
 None
 1.02A 4n48B-1pekE:
2.5		 4n48B-1pekE:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A  97
GLY A  77
LEU A  29
ILE A  54
GLY A  62
 None
 1.00A 4n48B-1poxA:
undetectable		 4n48B-1poxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III

(Schizosaccharomyces
pombe) 		PF00291
(PALP) 		5 GLY A 190
GLY A 162
PHE A  56
GLY A 185
LEU A 242
 None
None
PLP  A 350 (-4.7A)
PLP  A 350 (-3.4A)
None
 1.09A 4n48B-1v71A:
undetectable		 4n48B-1v71A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida) 		PF01212
(Beta_elim_lyase) 		5 GLY A 154
LEU A 187
THR A 198
GLY A 180
LEU A 206
 None
 1.01A 4n48B-1v72A:
2.5		 4n48B-1v72A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xec DECORIN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 ALA A 166
GLY A 189
PHE A 167
ILE A 204
THR A 205
 None
 1.14A 4n48B-1xecA:
undetectable		 4n48B-1xecA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 GLY A 108
GLY A 109
THR A  24
ILE A  47
GLY A  31
 None
 0.96A 4n48B-1yxmA:
7.6		 4n48B-1yxmA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdu NADPH OXIDASE

(Lactobacillus
sanfranciscensis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 CYH A 242
GLY A 244
ILE A 240
GLY A 161
LEU A 164
 None
ADP  A 501 (-3.0A)
None
None
None
 1.08A 4n48B-2cduA:
undetectable		 4n48B-2cduA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtx METHIONINE
AMINOPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		5 ALA A  58
GLY A 107
THR A 237
LEU A 248
GLY A 174
 None
 1.20A 4n48B-2gtxA:
undetectable		 4n48B-2gtxA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		5 GLY A  20
GLY A  22
PHE A  24
ILE A  61
THR A  62
 SAH  A 328 (-3.3A)
None
SAH  A 328 (-4.8A)
SAH  A 328 (-4.3A)
SAH  A 328 ( 4.3A)
 0.58A 4n48B-2i9kA:
7.1		 4n48B-2i9kA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 GLY A 259
GLY A 261
ILE A 231
GLY A 186
LEU A 235
 None
 1.00A 4n48B-2iu4A:
undetectable		 4n48B-2iu4A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		5 GLY A  64
GLY A  81
LEU A  18
ASN A  20
LEU A  75
 None
 0.86A 4n48B-2iuyA:
2.9		 4n48B-2iuyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY X 113
GLY X 111
THR X 116
ASN X 114
GLY X 107
 None
2MD  X 801 (-3.8A)
None
None
None
 1.12A 4n48B-2iv2X:
undetectable		 4n48B-2iv2X:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjz PILO PROTEIN

(Pseudomonas
aeruginosa) 		PF04350
(PilO) 		5 GLY A 122
GLY A 124
ILE A 116
GLY A 163
LEU A 167
 None
 1.19A 4n48B-2rjzA:
undetectable		 4n48B-2rjzA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vug PAB1020

(Pyrococcus
abyssi) 		PF09414
(RNA_ligase) 		5 GLY A  55
GLY A 116
LEU A  52
GLY A  31
LEU A  26
 None
 1.02A 4n48B-2vugA:
undetectable		 4n48B-2vugA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa2 NON-STRUCTURAL
PROTEIN 5

(Modoc virus) 		PF01728
(FtsJ) 		5 GLY A  84
GLY A  86
THR A 105
LEU A 106
THR A 134
 SAM  A1248 (-3.4A)
SAM  A1248 (-4.4A)
SAM  A1248 (-4.5A)
SAM  A1248 (-4.1A)
SAM  A1248 (-3.8A)
 0.72A 4n48B-2wa2A:
16.9		 4n48B-2wa2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8v CLASS III CHITINASE,
PUTATIVE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		5 ALA A 160
GLY A  91
GLY A  92
GLY A  88
LEU A 124
 None
 0.97A 4n48B-2y8vA:
undetectable		 4n48B-2y8vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		5 ALA A 389
GLY A 332
THR A 160
THR A 319
GLY A  89
 None
 1.21A 4n48B-2z2zA:
undetectable		 4n48B-2z2zA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zau SELENIDE, WATER
DIKINASE

(Aquifex
aeolicus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 GLY A 296
GLY A 297
ILE A  62
THR A  63
GLY A 222
 None
 1.17A 4n48B-2zauA:
undetectable		 4n48B-2zauA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		5 ALA A 228
GLY A 585
GLY A 495
THR A 550
ILE A 520
 None
 1.13A 4n48B-3cf4A:
2.0		 4n48B-3cf4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ALA A 529
GLY A 481
GLY A 484
THR A 559
GLY A 512
 None
 0.98A 4n48B-3cmgA:
undetectable		 4n48B-3cmgA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		5 ALA A 255
GLY A 251
GLY A 141
ILE A 219
GLY A 203
 None
 1.06A 4n48B-3cwcA:
undetectable		 4n48B-3cwcA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dci ARYLESTERASE

(Agrobacterium
fabrum) 		PF13472
(Lipase_GDSL_2) 		5 ALA A  69
GLY A   8
THR A  12
LEU A  11
GLY A  49
 None
None
None
ACY  A 220 ( 4.9A)
ACY  A 220 ( 3.8A)
 0.80A 4n48B-3dciA:
2.9		 4n48B-3dciA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		5 GLY A  83
GLY A  85
THR A 104
LEU A 105
ILE A 132
 SAH  A 901 (-3.3A)
SAH  A 901 ( 4.4A)
SAH  A 901 (-4.5A)
SAH  A 901 (-4.0A)
SAH  A 901 (-3.8A)
 0.60A 4n48B-3evcA:
16.8		 4n48B-3evcA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9i 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Rickettsia
prowazekii) 		PF13561
(adh_short_C2) 		5 GLY A 138
GLY A 144
ILE A 201
THR A 205
GLY A 179
 None
 0.95A 4n48B-3f9iA:
6.7		 4n48B-3f9iA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 ALA A 368
GLY A 388
ILE A 120
GLY A  14
LEU A  42
 None
 1.18A 4n48B-3g05A:
undetectable		 4n48B-3g05A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga2 ENDONUCLEASE V

(Bacillus
subtilis) 		PF04493
(Endonuclease_5) 		5 ALA A 132
CYH A 192
GLY A 119
GLY A 127
LEU A 190
 None
 1.14A 4n48B-3ga2A:
undetectable		 4n48B-3ga2A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 109
GLY A  96
GLY A 103
GLY A  93
LEU A 285
 None
 0.73A 4n48B-3gazA:
6.7		 4n48B-3gazA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00497
(SBP_bac_3) 		5 GLY A  75
PHE A  76
THR A  57
ILE A 114
GLY A 117
 None
 1.24A 4n48B-3i6vA:
undetectable		 4n48B-3i6vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN

(Neisseria
gonorrhoeae) 		PF00588
(SpoU_methylase) 		5 GLY A 145
GLY A 150
THR A  20
ILE A  45
LEU A  43
 None
 1.14A 4n48B-3ic6A:
undetectable		 4n48B-3ic6A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcu PROBABLE FORMATE
TRANSPORTER 1

(Escherichia
coli) 		PF01226
(Form_Nir_trans) 		5 ALA A 227
GLY A 143
GLY A 146
ASN A 142
GLY A 236
 None
 1.18A 4n48B-3kcuA:
undetectable		 4n48B-3kcuA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzx FERREDOXIN--NADP
REDUCTASE 2

(Bacillus
subtilis) 		PF07992
(Pyr_redox_2) 		5 GLY A 122
PHE A 124
ILE A  35
GLY A  16
LEU A  20
 FAD  A1000 (-3.7A)
FAD  A1000 (-4.9A)
None
FAD  A1000 (-3.4A)
None
 1.13A 4n48B-3lzxA:
undetectable		 4n48B-3lzxA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqt MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 CYH A 286
GLY A  98
THR A 262
GLY A 288
LEU A 292
 None
 1.09A 4n48B-3mqtA:
undetectable		 4n48B-3mqtA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzg PUTATIVE RACEMASE

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 CYH A 291
GLY A 103
THR A 267
GLY A 293
LEU A 297
 None
 1.12A 4n48B-3nzgA:
undetectable		 4n48B-3nzgA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r50 IPOMOELIN

(Ipomoea batatas) 		PF01419
(Jacalin) 		5 GLY A 148
GLY A  14
ILE A  84
GLY A 135
LEU A  32
 None
 0.96A 4n48B-3r50A:
undetectable		 4n48B-3r50A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrl SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
A

(Helicobacter
pylori) 		PF01144
(CoA_trans) 		5 GLY A  25
GLY A  30
ASN A  52
ILE A  21
THR A  20
 None
 1.21A 4n48B-3rrlA:
undetectable		 4n48B-3rrlA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se7 VANA

(-) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 ALA A  21
GLY A  51
ILE A  86
GLY A   4
LEU A  88
 None
 1.16A 4n48B-3se7A:
undetectable		 4n48B-3se7A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se7 VANA

(-) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 ALA A  25
GLY A  51
ILE A  86
GLY A   4
LEU A  88
 None
 1.07A 4n48B-3se7A:
undetectable		 4n48B-3se7A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy8 ROCR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00563
(EAL) 		5 ALA A  34
LEU A  65
ILE A  98
THR A  94
LEU A  82
 None
 1.22A 4n48B-3sy8A:
undetectable		 4n48B-3sy8A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tav METHIONINE
AMINOPEPTIDASE

(Mycobacteroides
abscessus) 		PF00557
(Peptidase_M24) 		5 GLY A 114
GLY A 106
THR A 250
LEU A 261
GLY A 187
 None
 1.02A 4n48B-3tavA:
undetectable		 4n48B-3tavA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ALA A  68
GLY A 114
LEU A 338
ILE A 341
THR A 317
 None
 1.17A 4n48B-3tqpA:
undetectable		 4n48B-3tqpA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 ALA A 916
GLY A1010
GLY A 911
GLY A 930
LEU A 400
 None
 1.21A 4n48B-3w9hA:
undetectable		 4n48B-3w9hA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01554
(MatE) 		5 GLY A 158
GLY A 156
ILE A  85
GLY A 164
LEU A  12
 None
 0.66A 4n48B-3wbnA:
undetectable		 4n48B-3wbnA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		5 ALA A 222
GLY A 135
GLY A  82
PHE A  81
GLY A 138
 None
 1.14A 4n48B-3wc3A:
undetectable		 4n48B-3wc3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwp (S)-HYDROXYNITRILE
LYASE

(Baliospermum
montanum) 		PF00561
(Abhydrolase_1) 		5 GLY A  81
GLY A  83
ILE A 157
THR A 152
LEU A 148
 None
None
CL  A 309 ( 4.0A)
None
None
 1.02A 4n48B-3wwpA:
undetectable		 4n48B-3wwpA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF13360
(PQQ_2) 		5 GLY A 234
GLY A 176
THR A 271
ASN A 255
GLY A 252
 None
None
None
CA  A 702 ( 3.0A)
None
 1.00A 4n48B-4aahA:
undetectable		 4n48B-4aahA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bk1 PROBABLE SALICYLATE
MONOOXYGENASE

(Rhodococcus
jostii) 		PF01494
(FAD_binding_3) 		5 GLY A  18
GLY A  14
LEU A  23
ASN A  21
LEU A  58
 None
FAD  A1398 ( 4.6A)
None
None
None
 1.17A 4n48B-4bk1A:
undetectable		 4n48B-4bk1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)

(Legionella
pneumophila) 		PF00351
(Biopterin_H) 		5 GLY A 183
GLY A 181
PHE A  47
ILE A 188
LEU A  31
 None
 1.18A 4n48B-4bptA:
undetectable		 4n48B-4bptA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c89 ESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		5 ALA A 314
GLY A 107
GLY A 106
ILE A 244
LEU A  47
 None
 1.07A 4n48B-4c89A:
undetectable		 4n48B-4c89A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cta CINA-LIKE PROTEIN

(Thermus
thermophilus) 		PF00994
(MoCF_biosynth)
PF02464
(CinA) 		5 ALA A 135
GLY A  68
GLY A 152
LEU A   7
LEU A 147
 None
ATP  A 400 (-3.2A)
ATP  A 400 (-3.4A)
None
None
 1.01A 4n48B-4ctaA:
undetectable		 4n48B-4ctaA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dna PROBABLE GLUTATHIONE
REDUCTASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 134
GLY A 300
ILE A 288
THR A 282
LEU A 275
 None
 1.16A 4n48B-4dnaA:
undetectable		 4n48B-4dnaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ALA A 429
GLY A 426
ILE A 218
GLY A 374
LEU A 399
 None
 1.23A 4n48B-4f7kA:
undetectable		 4n48B-4f7kA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl3 PUTATIVE
GLUCOAMYLASE

(Bacteroides
uniformis) 		PF10091
(Glycoamylase) 		5 ALA A 339
THR A 250
ASN A 219
GLY A 271
LEU A 262
 None
 1.10A 4n48B-4gl3A:
undetectable		 4n48B-4gl3A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr6 LECTIN

(Trichosanthes
anguina) 		PF00652
(Ricin_B_lectin) 		5 GLY C  52
PHE C  48
ASN C  97
ILE C  74
LEU C  33
 None
 1.20A 4n48B-4hr6C:
undetectable		 4n48B-4hr6C:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz4 GLUTATHIONE-S-TRANSF
ERASE

(Actinobacillus
pleuropneumoniae) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ALA A 114
GLY A 134
ILE A 181
THR A 182
GLY A 169
 None
 1.16A 4n48B-4hz4A:
undetectable		 4n48B-4hz4A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 320
GLY A 285
GLY A 289
ILE A  55
THR A  52
 None
 1.12A 4n48B-4j3zA:
undetectable		 4n48B-4j3zA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6o METALLOPHOSPHOESTERA
SE

(Ruminiclostridium
thermocellum) 		PF00149
(Metallophos) 		5 GLY A 274
LEU A 272
ASN A 273
THR A 286
LEU A 283
 None
 1.11A 4n48B-4j6oA:
undetectable		 4n48B-4j6oA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 GLY A  64
PHE A 382
THR A  67
ASN A  62
LEU A  74
 CA  A 702 ( 4.9A)
None
GOL  A 715 (-4.8A)
EDO  A 725 (-3.8A)
None
 1.18A 4n48B-4jclA:
undetectable		 4n48B-4jclA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A3851
GLY A3838
THR A3874
LEU A3871
LEU A3929
 None
 1.12A 4n48B-4kc5A:
undetectable		 4n48B-4kc5A:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		12 ALA A 236
CYH A 277
GLY A 279
GLY A 281
PHE A 283
THR A 301
LEU A 302
ASN A 306
ILE A 336
THR A 337
GLY A 365
LEU A 383
 SAM  A 601 (-3.2A)
SAM  A 601 (-3.7A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.5A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
None
SAM  A 601 (-4.1A)
SAM  A 601 ( 3.9A)
SAM  A 601 ( 4.0A)
SAM  A 601 (-4.6A)
 0.23A 4n48B-4n49A:
67.5		 4n48B-4n49A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 GLY A  61
GLY A  58
ILE A 319
GLY A 266
LEU A 271
 None
 0.94A 4n48B-4pvvA:
3.3		 4n48B-4pvvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q34 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12697
(Abhydrolase_6) 		5 ALA A  33
GLY A  49
GLY A  36
THR A 116
GLY A 113
 None
 0.94A 4n48B-4q34A:
undetectable		 4n48B-4q34A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiq D-XYLOSE-PROTON
SYMPORTER

(Escherichia
coli) 		PF00083
(Sugar_tr) 		5 ALA A 456
GLY A 351
GLY A 348
THR A 361
GLY A 449
 None
 1.03A 4n48B-4qiqA:
undetectable		 4n48B-4qiqA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r72 ABC-TYPE FE3+
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Actinobacillus
pleuropneumoniae) 		PF13343
(SBP_bac_6) 		5 GLY A 225
PHE A 158
LEU A 288
GLY A 108
LEU A 204
 None
None
GOL  A 404 (-3.9A)
None
None
 0.88A 4n48B-4r72A:
undetectable		 4n48B-4r72A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsj CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF06470
(SMC_hinge) 		5 ALA A 563
GLY A 521
ILE A 606
GLY A 524
LEU A 529
 None
 1.18A 4n48B-4rsjA:
undetectable		 4n48B-4rsjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsj CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF06470
(SMC_hinge) 		5 ALA A 563
GLY A 521
PHE A 577
ILE A 606
GLY A 524
 None
 1.23A 4n48B-4rsjA:
undetectable		 4n48B-4rsjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 5 GLY B 268
GLY B 210
THR B 305
ASN B 289
GLY B 286
 None
None
None
CA  B 701 ( 2.8A)
None
 1.05A 4n48B-4tqoB:
undetectable		 4n48B-4tqoB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4who PROTOCATECHUATE
3,4-DIOXYGENASE
ALPHA CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C) 		5 GLY A 112
GLY A  77
ILE A  49
THR A 181
GLY A  46
 None
 1.02A 4n48B-4whoA:
undetectable		 4n48B-4whoA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 GLY A 320
GLY A 269
ILE A 316
GLY A 325
LEU A 177
 None
 0.81A 4n48B-4y9lA:
undetectable		 4n48B-4y9lA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg8 ENDOGLUCANASE

(Perinereis
brevicirris) 		PF00759
(Glyco_hydro_9) 		5 ALA A 207
GLY A 120
GLY A  69
PHE A  68
GLY A 123
 None
 1.15A 4n48B-4zg8A:
undetectable		 4n48B-4zg8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2z EXFOLIATIVE TOXIN D2

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 GLY A  83
GLY A  71
THR A  93
ILE A 148
LEU A 270
 None
 1.21A 4n48B-5c2zA:
undetectable		 4n48B-5c2zA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01008
(IF-2B) 		5 ALA A 352
GLY A 283
ASN A 281
ILE A 334
LEU A 299
 None
 1.04A 4n48B-5dboA:
2.2		 4n48B-5dboA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7r LMO0178 PROTEIN

(Listeria
monocytogenes) 		no annotation 5 ALA E 149
GLY E 381
THR E 100
LEU E  99
LEU E 143
 None
 1.24A 4n48B-5f7rE:
undetectable		 4n48B-5f7rE:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcd MCCD

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 ALA A  98
CYH A  68
GLY A  73
ILE A  39
LEU A 123
 None
 1.14A 4n48B-5fcdA:
8.5		 4n48B-5fcdA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D

(Streptococcus
pyogenes;
Aequorea
victoria) 		PF01353
(GFP)
PF13930
(Endonuclea_NS_2) 		5 GLY A1103
GLY A1101
ILE A1204
GLY A1106
LEU A1189
 None
 1.16A 4n48B-5fguA:
undetectable		 4n48B-5fguA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgw EXTRACELLULAR
STREPTODORNASE D

(Streptococcus
pyogenes) 		PF01223
(Endonuclease_NS) 		5 GLY A 103
GLY A 101
ILE A 204
GLY A 106
LEU A 189
 None
 1.16A 4n48B-5fgwA:
undetectable		 4n48B-5fgwA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ij6 LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 ALA A 136
GLY A  44
GLY A  73
ASN A  46
ILE A 247
 LPA  A 401 ( 3.8A)
None
LPA  A 401 (-3.7A)
None
None
 1.04A 4n48B-5ij6A:
undetectable		 4n48B-5ij6A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kss 5'-NUCLEOTIDASE SURE

(Xylella
fastidiosa) 		PF01975
(SurE) 		5 GLY A 105
THR A  69
THR A  77
GLY A 113
LEU A 116
 CL  A 504 ( 4.9A)
None
None
None
None
 1.15A 4n48B-5kssA:
undetectable		 4n48B-5kssA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT

(Ovis aries) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N)
PF06455
(NADH5_C) 		5 ALA L 415
GLY L 311
THR L 316
LEU L 324
ILE L 319
 None
 1.06A 4n48B-5lnkL:
undetectable		 4n48B-5lnkL:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		5 GLY A  90
GLY A  87
PHE A 118
LEU A 220
ILE A  82
 None
FAD  A 700 (-3.5A)
None
None
None
 0.82A 4n48B-5mq6A:
undetectable		 4n48B-5mq6A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		5 GLY A 355
GLY A 377
ILE A 313
THR A 312
GLY A 337
 None
 1.18A 4n48B-5n8pA:
undetectable		 4n48B-5n8pA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		5 GLY A 355
GLY A 377
ILE A 313
THR A 312
GLY A 337
 None
 1.17A 4n48B-5n97A:
undetectable		 4n48B-5n97A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 5 GLY A 438
GLY A 421
ASN A 437
ILE A 442
THR A 448
 None
None
NAG  A1129 (-1.9A)
None
None
 1.09A 4n48B-5nbsA:
2.7		 4n48B-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE

(Fusobacterium
nucleatum) 		PF00480
(ROK) 		5 GLY A 276
GLY A 279
ILE A  13
THR A  32
GLY A  64
 None
 1.05A 4n48B-5nckA:
undetectable		 4n48B-5nckA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		5 ALA A  73
GLY A  69
PHE A  70
THR A  41
LEU A 114
 None
None
LB2  A 502 (-3.7A)
None
None
 0.98A 4n48B-5u6sA:
2.9		 4n48B-5u6sA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		5 CYH A 401
LEU A 405
ILE A 387
GLY A 398
LEU A 451
 None
 0.81A 4n48B-5uj6A:
undetectable		 4n48B-5uj6A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdn GLUTATHIONE
OXIDOREDUCTASE

(Yersinia pestis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 142
GLY A 307
ILE A 295
THR A 289
LEU A 282
 None
 0.92A 4n48B-5vdnA:
undetectable		 4n48B-5vdnA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 ALA B  97
GLY B 109
ILE B 135
THR B 166
GLY B 144
 None
None
None
None
GDP  B 501 (-4.6A)
 1.02A 4n48B-5w3jB:
4.1		 4n48B-5w3jB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfh SALT STRESS-INDUCED
PROTEIN

(Oryza sativa) 		no annotation 5 GLY A 140
GLY A   7
ILE A  75
GLY A 127
LEU A  26
 None
 1.01A 4n48B-5xfhA:
undetectable		 4n48B-5xfhA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		5 CYH A 294
GLY A 292
GLY A 238
GLY A 308
LEU A 315
 None
 1.21A 4n48B-5xgsA:
undetectable		 4n48B-5xgsA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4h NUCLEOPORIN GLE1

(Chaetomium
thermophilum) 		no annotation 5 ALA A 344
GLY A 421
GLY A 419
LEU A 469
LEU A 516
 None
 1.20A 4n48B-6b4hA:
undetectable		 4n48B-6b4hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D

(Pyrococcus
furiosus) 		no annotation 5 ALA H 343
GLY H 325
GLY H 327
ILE H 219
LEU H 223
 None
 0.89A 4n48B-6cfwH:
undetectable		 4n48B-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f74 ALCOHOL OXIDASE

(Thermothelomyces
thermophila) 		no annotation 5 GLY A 247
GLY A 229
THR A 250
GLY A 244
LEU A 489
 None
FAD  A 601 ( 4.0A)
None
None
None
 1.03A 4n48B-6f74A:
undetectable		 4n48B-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a88 CHLOROPEROXIDASE L

(Streptomyces
lividans) 		PF00561
(Abhydrolase_1) 		4 ASN A 169
PRO A 164
GLY A 167
ASP A 225
 None
 1.15A 4n48B-1a88A:
2.2		 4n48B-1a88A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 ASN A 182
GLY A 174
ASP A 101
ASP A 215
 FMN  A 751 (-4.9A)
FMN  A 751 (-3.2A)
None
None
 1.09A 4n48B-1amoA:
3.1		 4n48B-1amoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)

(Homo sapiens) 		PF00258
(Flavodoxin_1) 		4 ASN A 122
GLY A 114
ASP A  41
ASP A 155
 None
FMN  A 190 (-3.2A)
None
None
 1.05A 4n48B-1b1cA:
undetectable		 4n48B-1b1cA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlp LECTIN SCAFET
PRECURSOR

(Hyacinthoides
hispanica) 		PF01453
(B_lectin) 		4 ASN A 190
PRO A 189
GLY A 191
ASP A 194
 None
 1.13A 4n48B-1dlpA:
undetectable		 4n48B-1dlpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		4 PRO A  62
GLY A  64
ASP A  99
ASP A 124
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
 0.34A 4n48B-1eizA:
18.3		 4n48B-1eizA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		4 PRO A 329
GLY A 327
ASP A 112
ASP A 255
 None
 1.12A 4n48B-1gcyA:
undetectable		 4n48B-1gcyA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ASN A  77
PRO A  54
GLY A   7
ASP A  17
 None
 1.01A 4n48B-1i2dA:
undetectable		 4n48B-1i2dA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		4 ASN A 225
PRO A 223
GLY A 216
ASP A 440
 None
 0.90A 4n48B-1jmzA:
undetectable		 4n48B-1jmzA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jny ELONGATION FACTOR
1-ALPHA

(Sulfolobus
solfataricus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 PRO A 269
GLY A 271
ASP A 239
ASP A 306
 None
 1.11A 4n48B-1jnyA:
undetectable		 4n48B-1jnyA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 PRO A 266
GLY A  67
ASP A 284
ASP A 269
 None
 1.08A 4n48B-1kfiA:
undetectable		 4n48B-1kfiA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ASN A 100
GLY A 104
ASP A 124
ASP A  97
 None
 1.13A 4n48B-1m53A:
undetectable		 4n48B-1m53A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 PRO A 357
GLY A 355
ASP A 127
ASP A 283
 None
 1.10A 4n48B-1qhoA:
undetectable		 4n48B-1qhoA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus) 		PF00328
(His_Phos_2) 		4 PRO A 178
GLY A 139
ASP A 311
ASP A 188
 None
 0.94A 4n48B-1skaA:
undetectable		 4n48B-1skaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		4 PRO A 257
GLY A 259
ASP A 303
ASP A 322
 None
 1.08A 4n48B-1sqgA:
9.7		 4n48B-1sqgA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjg PUTATIVE LIPASE FROM
THE G-D-S-L FAMILY

(Nostoc sp. PCC
7120) 		PF13472
(Lipase_GDSL_2) 		4 PRO A  96
GLY A  94
ASP A  16
ASP A 133
 None
 0.90A 4n48B-1vjgA:
undetectable		 4n48B-1vjgA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		4 PRO A  98
GLY A 100
ASP A  93
ASP A  83
 None
 1.04A 4n48B-1y3tA:
undetectable		 4n48B-1y3tA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		4 ASN A 672
GLY A 675
ASP A 313
ASP A 136
 None
 0.75A 4n48B-1z26A:
undetectable		 4n48B-1z26A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE

([Candida]
tenuis) 		PF00248
(Aldo_ket_red) 		4 ASN A  28
GLY A  53
ASP A 109
ASP A 102
 None
 1.11A 4n48B-1z9aA:
undetectable		 4n48B-1z9aA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoi ESTERASE

(Pseudomonas
putida) 		PF00561
(Abhydrolase_1) 		4 ASN A 170
PRO A 165
GLY A 168
ASP A 226
 None
 1.13A 4n48B-1zoiA:
2.3		 4n48B-1zoiA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		4 PRO A 329
GLY A 327
ASP A 112
ASP A 255
 None
 1.12A 4n48B-2amgA:
undetectable		 4n48B-2amgA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2apj PUTATIVE ESTERASE

(Arabidopsis
thaliana) 		PF03629
(SASA) 		4 PRO A  79
GLY A  35
ASP A  70
ASP A  85
 None
SEB  A  31 ( 3.5A)
None
None
 1.02A 4n48B-2apjA:
undetectable		 4n48B-2apjA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bov MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		4 PRO B1187
GLY B1185
ASP B1227
ASP B1233
 None
 0.99A 4n48B-2bovB:
undetectable		 4n48B-2bovB:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		4 PRO A 194
GLY A 204
ASP A 107
ASP A 124
 None
FMT  A1798 (-3.7A)
None
None
 1.08A 4n48B-2c4mA:
undetectable		 4n48B-2c4mA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1

(Bos taurus) 		PF02274
(Amidinotransf) 		4 ASN A 146
GLY A 149
ASP A 102
ASP A 120
 None
 1.12A 4n48B-2ci6A:
undetectable		 4n48B-2ci6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF00496
(SBP_bac_5) 		4 ASN A 502
PRO A 492
GLY A 505
ASP A 179
 None
 1.13A 4n48B-2d5wA:
undetectable		 4n48B-2d5wA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		4 ASN A 223
PRO A 215
GLY A 190
ASP A 237
 None
 1.15A 4n48B-2f2aA:
undetectable		 4n48B-2f2aA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE

(Sulfurisphaera
tokodaii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ASN A 328
GLY A 329
ASP A 112
ASP A 245
 None
 1.08A 4n48B-2f7lA:
undetectable		 4n48B-2f7lA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghs AGR_C_1268P

(Agrobacterium
fabrum) 		PF08450
(SGL) 		4 ASN A 125
PRO A 169
ASP A 212
ASP A 221
 EDO  A 317 (-3.0A)
None
None
EDO  A 317 (-3.7A)
 1.13A 4n48B-2ghsA:
undetectable		 4n48B-2ghsA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6e D-ARABINOSE
1-DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASN A  67
PRO A 114
GLY A 120
ASP A  44
 None
 1.03A 4n48B-2h6eA:
6.6		 4n48B-2h6eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6e D-ARABINOSE
1-DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASN A  67
PRO A 114
GLY A 121
ASP A  44
 None
 0.99A 4n48B-2h6eA:
6.6		 4n48B-2h6eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk7 SHIKIMATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ASN A  64
GLY A 243
ASP A  82
ASP A 106
 None
 1.14A 4n48B-2hk7A:
4.0		 4n48B-2hk7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz7 GLUTAMINYL-TRNA
SYNTHETASE

(Deinococcus
radiodurans) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 ASN A 236
GLY A 204
ASP A 142
ASP A 244
 None
 1.09A 4n48B-2hz7A:
undetectable		 4n48B-2hz7A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ii1 ACETAMIDASE

(Bacillus
halodurans) 		PF03069
(FmdA_AmdA) 		4 ASN A 277
PRO A 148
GLY A 146
ASP A 181
 CA  A 400 ( 4.3A)
None
None
CA  A 401 ( 2.3A)
 0.97A 4n48B-2ii1A:
undetectable		 4n48B-2ii1A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT

(Homo sapiens) 		PF00503
(G-alpha) 		4 ASN A 269
GLY A  45
ASP A 158
ASP A 150
 GDP  A 401 (-3.1A)
GDP  A 401 (-3.3A)
None
None
 1.12A 4n48B-2ik8A:
undetectable		 4n48B-2ik8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		4 ASN A  96
PRO A  91
GLY A  67
ASP A  24
 None
 0.89A 4n48B-2qvlA:
undetectable		 4n48B-2qvlA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t ROUNDABOUT HOMOLOG 1

(Homo sapiens) 		PF13927
(Ig_3) 		4 PRO A  84
GLY A  82
ASP A  76
ASP A 141
 None
 1.07A 4n48B-2v9tA:
undetectable		 4n48B-2v9tA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		4 ASN A 295
GLY A 294
ASP A  45
ASP A 344
 None
 1.11A 4n48B-2w61A:
undetectable		 4n48B-2w61A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xw7 DIHYDROFOLATE
REDUCTASE

(Mycolicibacterium
smegmatis) 		PF01872
(RibD_C) 		4 ASN A 160
PRO A  35
GLY A  37
ASP A  33
 None
 1.00A 4n48B-2xw7A:
undetectable		 4n48B-2xw7A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6g XYLANASE

(Rhodothermus
marinus) 		PF02018
(CBM_4_9) 		4 PRO A  77
GLY A  27
ASP A 111
ASP A  29
 None
None
None
BGC  A1173 (-3.7A)
 0.88A 4n48B-2y6gA:
undetectable		 4n48B-2y6gA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		4 PRO A 270
GLY A 272
ASP A 318
ASP A 337
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.51A 4n48B-2yxlA:
10.6		 4n48B-2yxlA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		4 PRO A 439
GLY A 441
ASP A 459
ASP A 443
 None
 1.02A 4n48B-2zuyA:
undetectable		 4n48B-2zuyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		4 PRO A  94
GLY A  96
ASP A 142
ASP A 163
 SFG  A 500 (-3.9A)
SFG  A 500 (-3.5A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.7A)
 0.46A 4n48B-3a4tA:
9.6		 4n48B-3a4tA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE

(Streptococcus
pneumoniae) 		PF04914
(DltD) 		4 ASN A 142
GLY A 143
ASP A 376
ASP A 145
 None
 1.05A 4n48B-3bmaA:
undetectable		 4n48B-3bmaA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 PRO A 356
GLY A 354
ASP A 136
ASP A 283
 None
 1.09A 4n48B-3bmwA:
undetectable		 4n48B-3bmwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis) 		PF01274
(Malate_synthase) 		4 PRO A 164
GLY A 166
ASP A  96
ASP A 117
 None
None
None
MG  A   1 ( 4.7A)
 1.06A 4n48B-3cuxA:
undetectable		 4n48B-3cuxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		4 PRO A  49
GLY A  51
ASP A  83
ASP A 111
 SAM  A   1 (-3.5A)
SAM  A   1 (-3.2A)
SAM  A   1 (-3.6A)
SAM  A   1 (-3.7A)
 0.35A 4n48B-3douA:
16.3		 4n48B-3douA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 PRO A 263
GLY A 256
ASP A 166
ASP A 286
 None
 1.00A 4n48B-3eh7A:
undetectable		 4n48B-3eh7A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fby CARTILAGE OLIGOMERIC
MATRIX PROTEIN

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		4 PRO A 633
GLY A 675
ASP A 659
ASP A 670
 None
 0.94A 4n48B-3fbyA:
undetectable		 4n48B-3fbyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l07 BIFUNCTIONAL PROTEIN
FOLD

(Francisella
tularensis) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 ASN A 232
PRO A 212
GLY A 210
ASP A 228
 None
 1.12A 4n48B-3l07A:
4.4		 4n48B-3l07A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6q PEPTIDE DEFORMYLASE
1B

(Arabidopsis
thaliana) 		PF01327
(Pep_deformylase) 		4 ASN A  52
PRO A  47
GLY A  50
ASP A   8
 None
 1.16A 4n48B-3m6qA:
undetectable		 4n48B-3m6qA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngx BIFUNCTIONAL PROTEIN
FOLD

(Thermoplasma
acidophilum) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 ASN A 224
PRO A 204
GLY A 202
ASP A 220
 None
 1.06A 4n48B-3ngxA:
3.6		 4n48B-3ngxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		4 ASN A  31
GLY A  80
ASP A 168
ASP A  26
 None
None
ATP  A 763 ( 4.7A)
None
 1.15A 4n48B-3o8lA:
undetectable		 4n48B-3o8lA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		4 ASN A 339
PRO A 546
GLY A 338
ASP A 434
 None
 1.13A 4n48B-3ob8A:
undetectable		 4n48B-3ob8A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A

(Escherichia
coli) 		PF00004
(AAA)
PF12002
(MgsA_C)
PF16193
(AAA_assoc_2) 		4 ASN A 305
PRO A 308
GLY A 304
ASP A 319
 None
 1.04A 4n48B-3pvsA:
undetectable		 4n48B-3pvsA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwu DNA LIGASE

(Aquifex
aeolicus) 		PF09414
(RNA_ligase) 		4 ASN A 135
GLY A 132
ASP A 155
ASP A  79
 None
None
None
CA  A 601 (-3.1A)
 1.15A 4n48B-3qwuA:
undetectable		 4n48B-3qwuA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r79 UNCHARACTERIZED
PROTEIN

(Agrobacterium
fabrum) 		PF01168
(Ala_racemase_N) 		4 ASN A 171
GLY A 173
ASP A  17
ASP A 198
 None
 1.11A 4n48B-3r79A:
undetectable		 4n48B-3r79A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4u PHND, SUBUNIT OF
ALKYLPHOSPHONATE ABC
TRANSPORTER

(Escherichia
coli) 		PF12974
(Phosphonate-bd) 		4 ASN A  66
PRO A 206
GLY A 204
ASP A 223
 None
 0.92A 4n48B-3s4uA:
undetectable		 4n48B-3s4uA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssm METHYLTRANSFERASE

(Micromonospora
griseorubida) 		no annotation 4 ASN A  55
PRO A  53
GLY A 149
ASP A 163
 None
 1.09A 4n48B-3ssmA:
9.9		 4n48B-3ssmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc8 LEUCINE
AMINOPEPTIDASE

(Parabacteroides
distasonis) 		PF04389
(Peptidase_M28) 		4 PRO A  59
GLY A 144
ASP A  72
ASP A 124
 None
 1.09A 4n48B-3tc8A:
undetectable		 4n48B-3tc8A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4y UNCHARACTERIZED
PROTEIN

(Desulfotomaculum
acetoxidans) 		PF10282
(Lactonase) 		4 ASN A 177
GLY A 129
ASP A  92
ASP A  41
 None
 0.98A 4n48B-3u4yA:
undetectable		 4n48B-3u4yA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyz RIBONUCLEASE P
PROTEIN COMPONENT 3

(Thermococcus
kodakarensis) 		PF01876
(RNase_P_p30) 		4 ASN A  99
PRO A 113
GLY A  94
ASP A 119
 None
 1.00A 4n48B-3wyzA:
undetectable		 4n48B-3wyzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cn8 PROXIMAL THREAD
MATRIX PROTEIN 1

(Mytilus
galloprovincialis) 		PF00092
(VWA) 		4 ASN A 265
PRO A 329
ASP A 339
ASP A 369
 None
EDO  A1449 ( 4.3A)
None
None
 1.12A 4n48B-4cn8A:
undetectable		 4n48B-4cn8A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora) 		PF02435
(Glyco_hydro_68) 		4 ASN A 359
PRO A 358
GLY A 360
ASP A 203
 None
None
None
FRU  A1415 (-2.9A)
 1.11A 4n48B-4d47A:
undetectable		 4n48B-4d47A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ekd GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(Q) SUBUNIT
ALPHA

(Mus musculus) 		PF00503
(G-alpha) 		4 ASN A 274
GLY A  51
ASP A 163
ASP A 155
 GDP  A 401 (-3.5A)
GDP  A 401 (-3.2A)
None
GDP  A 401 ( 4.8A)
 1.10A 4n48B-4ekdA:
undetectable		 4n48B-4ekdA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		4 PRO A 185
GLY A 186
ASP A 237
ASP A 255
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.67A 4n48B-4fzvA:
8.9		 4n48B-4fzvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		4 ASN A 213
GLY A 495
ASP A 262
ASP A 189
 None
 0.74A 4n48B-4hwvA:
undetectable		 4n48B-4hwvA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4i 6-PHOSPHOFRUCTOKINAS
E

(Geobacillus
stearothermophilus) 		PF00365
(PFK) 		4 ASN A  17
GLY A  64
ASP A 129
ASP A  12
 None
 0.95A 4n48B-4i4iA:
undetectable		 4n48B-4i4iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 4 ASN A  73
PRO A  72
GLY A 161
ASP A 153
 None
 1.06A 4n48B-4j0kA:
2.2		 4n48B-4j0kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9z PUTATIVE
THIOL-DISULFIDE
OXIDOREDUCTASE

(Bacteroides
vulgatus) 		PF08534
(Redoxin) 		4 PRO A  26
GLY A  24
ASP A  44
ASP A 134
 None
 1.04A 4n48B-4k9zA:
undetectable		 4n48B-4k9zA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		4 ASN A  63
PRO A  26
GLY A 103
ASP A 188
 None
 0.92A 4n48B-4kpnA:
undetectable		 4n48B-4kpnA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		4 PRO A 281
GLY A 284
ASP A 334
ASP A 205
 None
 1.05A 4n48B-4maeA:
undetectable		 4n48B-4maeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)

(Streptococcus
agalactiae) 		PF10425
(SdrG_C_C) 		4 ASN A 481
PRO A 504
GLY A 506
ASP A 564
 None
 1.10A 4n48B-4mboA:
undetectable		 4n48B-4mboA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mks ENOLASE 2

(Lactobacillus
gasseri) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ASN A 158
GLY A 152
ASP A 276
ASP A 161
 None
 0.91A 4n48B-4mksA:
undetectable		 4n48B-4mksA:
22.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		4 ASN A 234
PRO A 280
GLY A 282
ASP A 333
 SAM  A 601 (-3.3A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
None
 0.97A 4n48B-4n49A:
67.5		 4n48B-4n49A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		5 ASN A 234
PRO A 280
GLY A 282
ASP A 335
ASP A 364
 SAM  A 601 (-3.3A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
 0.32A 4n48B-4n49A:
67.5		 4n48B-4n49A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		4 ASN A 183
PRO A 105
GLY A 102
ASP A 137
 None
 1.10A 4n48B-4pdhA:
undetectable		 4n48B-4pdhA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS

(Escherichia
coli) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 PRO A 155
GLY A 191
ASP A  88
ASP A 162
 None
 0.97A 4n48B-4pdxA:
undetectable		 4n48B-4pdxA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxa SMALL G PROTEIN
SIGNALING MODULATOR
1

(Mus musculus) 		no annotation 4 ASN B 294
PRO B 275
GLY B 276
ASP B 270
 None
 1.14A 4n48B-4qxaB:
undetectable		 4n48B-4qxaB:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf7 ARGININE KINASE

(Anthopleura
japonica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 PRO A 525
GLY A 528
ASP A 540
ASP A 530
 None
 1.07A 4n48B-4rf7A:
undetectable		 4n48B-4rf7A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE

(Homo sapiens) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASN A 455
GLY A 438
ASP A 112
ASP A 441
 None
 1.15A 4n48B-4ruhA:
undetectable		 4n48B-4ruhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII

(Loxosceles
intermedia) 		no annotation 4 PRO A 249
GLY A  27
ASP A 235
ASP A 254
 None
 1.09A 4n48B-4rw3A:
undetectable		 4n48B-4rw3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		4 ASN A  74
GLY A  54
ASP A 135
ASP A  13
 DDZ  A  53 ( 4.2A)
DDZ  A  53 ( 2.4A)
None
ZN  A1576 (-2.1A)
 1.03A 4n48B-4upiA:
undetectable		 4n48B-4upiA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w78 HYDRATASE CHSH2

(Mycobacterium
tuberculosis) 		no annotation 4 PRO B  83
GLY B  81
ASP B  16
ASP B  55
 None
 1.14A 4n48B-4w78B:
undetectable		 4n48B-4w78B:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus AP22) 		no annotation 4 ASN A 441
GLY A 407
ASP A 448
ASP A 437
 49S  A 814 (-3.6A)
49S  A 814 (-3.5A)
None
SO4  A 809 ( 4.7A)
 1.15A 4n48B-4y9vA:
undetectable		 4n48B-4y9vA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		4 PRO A 343
GLY A 341
ASP A 135
ASP A 264
 None
 1.13A 4n48B-5a2aA:
undetectable		 4n48B-5a2aA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aid MEP2

(Candida
albicans) 		PF00909
(Ammonium_transp) 		4 ASN A 350
PRO A 299
GLY A 185
ASP A 365
 None
 1.08A 4n48B-5aidA:
undetectable		 4n48B-5aidA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doe VIRION EGRESS
PROTEIN UL31 HOMOLOG

(Human
betaherpesvirus
5) 		PF02718
(Herpes_UL31) 		4 PRO B 111
GLY B 113
ASP B 187
ASP B 108
 None
 1.11A 4n48B-5doeB:
undetectable		 4n48B-5doeB:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed4 RESPONSE REGULATOR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 PRO A  94
GLY A 115
ASP A  27
ASP A 117
 None
None
CA  A 301 ( 4.3A)
None
 1.05A 4n48B-5ed4A:
2.5		 4n48B-5ed4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 ASN B 727
PRO B 750
GLY B 725
ASP B 809
 None
 0.97A 4n48B-5gjeB:
undetectable		 4n48B-5gjeB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		4 PRO e 275
GLY e 326
ASP e 311
ASP e 328
 None
 1.14A 4n48B-5gw5e:
undetectable		 4n48B-5gw5e:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i99 CONTACTIN-3

(Mus musculus) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		4 ASN A 679
PRO A 598
GLY A 596
ASP A 623
 None
 1.15A 4n48B-5i99A:
undetectable		 4n48B-5i99A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j04 ENOLASE

(Synechococcus
elongatus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ASN A 162
GLY A 156
ASP A 276
ASP A 165
 None
 1.14A 4n48B-5j04A:
undetectable		 4n48B-5j04A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbe INACTIVE
GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF02324
(Glyco_hydro_70) 		4 ASN A1287
GLY A1289
ASP A1380
ASP A1254
 None
 1.10A 4n48B-5jbeA:
undetectable		 4n48B-5jbeA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t7k AOAA13

(Aspergillus
oryzae) 		PF03067
(LPMO_10) 		4 ASN A  59
PRO A  47
GLY A  49
ASP A  36
 None
None
None
ZN  A 403 (-3.4A)
 1.11A 4n48B-5t7kA:
undetectable		 4n48B-5t7kA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w16 GLUTAMATE RACEMASE

(Thermus
thermophilus) 		no annotation 4 ASN A  76
GLY A 175
ASP A 150
ASP A 197
 DGL  A 301 (-4.3A)
None
None
None
 1.13A 4n48B-5w16A:
undetectable		 4n48B-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		4 PRO A 245
GLY A 247
ASP A 293
ASP A 323
 C  C  72 ( 4.7A)
None
None
C  C  72 ( 2.8A)
 0.56A 4n48B-5wwtA:
9.7		 4n48B-5wwtA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 PRO A 547
GLY A 720
ASP A 514
ASP A 544
 None
 0.81A 4n48B-5xapA:
undetectable		 4n48B-5xapA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 4 PRO A 314
GLY A 318
ASP A 422
ASP A 321
 None
 1.09A 4n48B-6byiA:
undetectable		 4n48B-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0q PIZZA6-AYW

(synthetic
construct) 		no annotation 4 ASN A 160
PRO A 183
GLY A 158
ASP A 240
 None
 1.14A 4n48B-6f0qA:
undetectable		 4n48B-6f0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2r -

(-) 		no annotation 4 PRO C 147
GLY C  72
ASP C  94
ASP C 126
 None
 0.93A 4n48B-6f2rC:
undetectable		 4n48B-6f2rC:
undetectable