SIMILAR PATTERNS OF AMINO ACIDS FOR 4N48_A_SAMA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ALA C  10
GLY C  14
ASP C 396
ASP C  19
 None
 0.84A 4n48A-1a5lC:
undetectable		 4n48A-1a5lC:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bk6 KARYOPHERIN ALPHA

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 ALA A 480
GLY A 481
ASP A 441
ASP A 435
 None
 1.00A 4n48A-1bk6A:
undetectable		 4n48A-1bk6A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		4 ALA A  35
GLY A  64
ASP A  99
ASP A 124
 SAM  A 301 (-3.3A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
 0.30A 4n48A-1eizA:
18.3		 4n48A-1eizA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsj FUSION PROTEIN
CONSISTING OF
STAPHYLOCOCCUS
ACCESSORY REGULATOR
PROTEIN R AND
MALTOSE BINDING
PROTEIN

(Escherichia
coli;
Staphylococcus
aureus) 		PF01547
(SBP_bac_1) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
GLC  A 672 (-3.0A)
 0.98A 4n48A-1hsjA:
undetectable		 4n48A-1hsjA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ASN A 157
ALA A 155
GLY A 151
ASP A 249
 None
 0.99A 4n48A-1iyxA:
undetectable		 4n48A-1iyxA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg1 PROTEIN (HTLV-1 GP21
ECTODOMAIN/MALTOSE-B
INDING PROTEIN
CHIMERA)

(Primate
T-lymphotropic
virus 1) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MAL  A 456 (-3.4A)
 0.98A 4n48A-1mg1A:
undetectable		 4n48A-1mg1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		4 ALA A 208
GLY A 206
ASP A 254
ASP A 170
 None
 0.96A 4n48A-1r6vA:
1.9		 4n48A-1r6vA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Escherichia
coli;
Drosophila
melanogaster) 		no annotation 4 ASN P 266
ALA P  50
GLY P  55
ASP P  13
 None
None
None
MAL  P 727 (-3.0A)
 0.97A 4n48A-1r6zP:
undetectable		 4n48A-1r6zP:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		4 ASN A 897
ALA A 911
GLY A 909
ASP A1151
 CA  A2005 (-3.3A)
None
CA  A2003 ( 4.8A)
None
 0.97A 4n48A-1ux6A:
undetectable		 4n48A-1ux6A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		4 ALA A 100
GLY A 105
ASP A  78
ASP A 102
 None
 0.90A 4n48A-1wx4A:
undetectable		 4n48A-1wx4A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x55 ASPARAGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ALA A 346
GLY A 324
ASP A 307
ASP A 348
 None
None
None
MG  A2001 ( 4.0A)
 0.90A 4n48A-1x55A:
undetectable		 4n48A-1x55A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4c MALTOSE BINDING
PROTEIN FUSED WITH
DESIGNED HELICAL
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
GLC  A 371 (-3.2A)
 0.95A 4n48A-1y4cA:
undetectable		 4n48A-1y4cA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		4 ASN A 672
GLY A 675
ASP A 313
ASP A 136
 None
 0.81A 4n48A-1z26A:
undetectable		 4n48A-1z26A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE

(Bacillus sp.
NG-27) 		PF00331
(Glyco_hydro_10) 		4 ASN A 328
ALA A 272
GLY A 332
ASP A 334
 None
 1.01A 4n48A-2f8qA:
undetectable		 4n48A-2f8qA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzm GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		4 ALA A  39
GLY A 241
ASP A  64
ASP A  37
 None
 0.85A 4n48A-2gzmA:
undetectable		 4n48A-2gzmA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ASN A 159
ALA A 157
GLY A 153
ASP A 251
 None
 0.93A 4n48A-2ptzA:
undetectable		 4n48A-2ptzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9z GLUTATHIONE AMIDE
REDUCTASE

(Marichromatium
gracile) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASN A  44
ALA A  37
GLY A  39
ASP A  99
 None
 0.86A 4n48A-2r9zA:
1.9		 4n48A-2r9zA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwf ALKALINE ACTIVE
ENDOXYLANASE

(Bacillus
halodurans) 		PF00331
(Glyco_hydro_10) 		4 ASN A 334
ALA A 278
GLY A 338
ASP A 340
 None
 0.97A 4n48A-2uwfA:
undetectable		 4n48A-2uwfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MTT  A1463 (-2.9A)
 0.96A 4n48A-2vgqA:
undetectable		 4n48A-2vgqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine leukemia
virus) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		4 ASN A 293
ALA A  77
GLY A  82
ASP A  40
 EDO  A1494 ( 4.1A)
None
EDO  A1494 (-4.4A)
MAL  A1488 (-3.0A)
 0.95A 4n48A-2xz3A:
undetectable		 4n48A-2xz3A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csg MALTOSE-BINDING
PROTEIN MONOBODY YS1
FUSION

(Escherichia
coli) 		PF00041
(fn3)
PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
 0.95A 4n48A-3csgA:
undetectable		 4n48A-3csgA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Escherichia
coli;
Arabidopsis
thaliana) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
GLC  A 672 (-3.1A)
 0.98A 4n48A-3dm0A:
undetectable		 4n48A-3dm0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		4 ALA A  22
GLY A  51
ASP A  83
ASP A 111
 SAM  A   1 (-3.3A)
SAM  A   1 (-3.2A)
SAM  A   1 (-3.6A)
SAM  A   1 (-3.7A)
 0.36A 4n48A-3douA:
16.4		 4n48A-3douA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		5 ASN X   9
ALA X  11
GLY X  12
ASP X 226
ASP X 344
 None
 1.22A 4n48A-3dwoX:
undetectable		 4n48A-3dwoX:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		4 ASN A 170
ALA A 172
GLY A 173
ASP A 273
 None
None
SO4  A 520 (-3.7A)
None
 0.98A 4n48A-3ed4A:
undetectable		 4n48A-3ed4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
GLC  A 672 (-3.2A)
 1.01A 4n48A-3f5fA:
undetectable		 4n48A-3f5fA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Escherichia
coli;
Dermatophagoides
pteronyssinus) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
GLC  A 672 (-3.1A)
 0.97A 4n48A-3h4zA:
undetectable		 4n48A-3h4zA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ist GLUTAMATE RACEMASE

(Listeria
monocytogenes) 		PF01177
(Asp_Glu_race) 		4 ALA A  37
GLY A 239
ASP A  62
ASP A  35
 None
 0.76A 4n48A-3istA:
undetectable		 4n48A-3istA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 ASN A  57
ALA A 303
GLY A  53
ASP A 324
 None
 0.99A 4n48A-3iveA:
undetectable		 4n48A-3iveA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Thermococcus
kodakarensis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ALA A 140
GLY A 138
ASP A 255
ASP A 311
 None
 0.95A 4n48A-3kdnA:
undetectable		 4n48A-3kdnA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		4 ALA A 280
GLY A 284
ASP A 669
ASP A 289
 None
 0.91A 4n48A-3la4A:
undetectable		 4n48A-3la4A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Novosphingobium
aromaticivorans) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 ALA A 307
GLY A  20
ASP A 140
ASP A 285
 FAD  A 416 (-3.5A)
FAD  A 416 (-3.3A)
None
FAD  A 416 (-2.9A)
 0.82A 4n48A-3lxdA:
undetectable		 4n48A-3lxdA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp6 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,LINKER,SAGA-
ASSOCIATED FACTOR 29

(Escherichia
coli;
Saccharomyces
cerevisiae;
unidentified) 		PF07039
(DUF1325)
PF13416
(SBP_bac_8) 		4 ASN A1005
ALA A 789
GLY A 794
ASP A 752
 None
None
None
MAL  A 600 (-2.9A)
 0.95A 4n48A-3mp6A:
undetectable		 4n48A-3mp6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n93 MALTOSE BINDING
PROTEIN-CRFR2 ALPHA

(Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 ASN A-103
ALA A-319
GLY A-314
ASP A-356
 None
None
None
MAL  A 111 (-3.1A)
 0.98A 4n48A-3n93A:
undetectable		 4n48A-3n93A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 ASN A -81
ALA A-297
GLY A-292
ASP A-334
 None
None
None
MAL  A5044 (-3.1A)
 1.00A 4n48A-3n94A:
undetectable		 4n48A-3n94A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF08205
(C2-set_2)
PF13416
(SBP_bac_8) 		4 ASN N 267
ALA N  51
GLY N  56
ASP N  14
 None
None
None
MLR  N2001 (-3.0A)
 0.95A 4n48A-3o3uN:
undetectable		 4n48A-3o3uN:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Escherichia
coli;
Arachis
duranensis) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MLR  A 400 (-3.1A)
 0.98A 4n48A-3ob4A:
undetectable		 4n48A-3ob4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 ASN A 515
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MAL  A 700 (-2.8A)
 0.96A 4n48A-3osqA:
undetectable		 4n48A-3osqA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MAL  A 700 (-3.1A)
 0.99A 4n48A-3osrA:
undetectable		 4n48A-3osrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2n 3,6-ANHYDRO-ALPHA-L-
GALACTOSIDASE

(Zobellia
galactanivorans) 		PF04616
(Glyco_hydro_43) 		4 ALA A 337
GLY A 319
ASP A 290
ASP A 339
 None
 1.00A 4n48A-3p2nA:
undetectable		 4n48A-3p2nA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py7 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PAXILLIN
LD1,PROTEIN E6
CHIMERA

(Escherichia
coli;
Homo sapiens;
Deltapapillomavirus
4) 		PF00518
(E6)
PF01547
(SBP_bac_1) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MLR  A 701 (-3.0A)
 0.99A 4n48A-3py7A:
undetectable		 4n48A-3py7A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		4 ALA A 195
GLY A 156
ASP A  94
ASP A 222
 None
 1.00A 4n48A-3ut2A:
undetectable		 4n48A-3ut2A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vd8 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
INTERFERON-INDUCIBLE
PROTEIN AIM2

(Escherichia
coli;
Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MTT  A1205 (-3.1A)
 0.96A 4n48A-3vd8A:
undetectable		 4n48A-3vd8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdn MONOAMINE OXIDASE N

(Aspergillus
niger) 		PF01593
(Amino_oxidase) 		4 ASN A 284
ALA A 289
GLY A 451
ASP A 458
 None
 0.80A 4n48A-3zdnA:
undetectable		 4n48A-3zdnA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		4 ASN A 185
ALA A 188
GLY A 166
ASP A 487
 None
 1.00A 4n48A-4dxbA:
undetectable		 4n48A-4dxbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
 0.95A 4n48A-4dxbA:
undetectable		 4n48A-4dxbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		PF00046
(Homeobox)
PF13416
(SBP_bac_8)
PF16878
(SIX1_SD) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MAL  A 601 (-2.9A)
 0.95A 4n48A-4egcA:
undetectable		 4n48A-4egcA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 ALA A  96
GLY A 131
ASP A 343
ASP A 129
 None
 0.99A 4n48A-4fixA:
undetectable		 4n48A-4fixA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Escherichia
coli;
Candida
albicans) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		4 ASN A-103
ALA A-319
GLY A-314
ASP A-356
 None
None
None
MTT  A 701 (-2.9A)
 0.97A 4n48A-4h1gA:
undetectable		 4n48A-4h1gA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		4 ALA A  79
GLY A 107
ASP A 221
ASP A  81
 None
 0.96A 4n48A-4hwvA:
undetectable		 4n48A-4hwvA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		4 ASN A 213
GLY A 495
ASP A 262
ASP A 189
 None
 0.75A 4n48A-4hwvA:
undetectable		 4n48A-4hwvA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4i 6-PHOSPHOFRUCTOKINAS
E

(Geobacillus
stearothermophilus) 		PF00365
(PFK) 		4 ASN A  17
GLY A  64
ASP A 129
ASP A  12
 None
 0.90A 4n48A-4i4iA:
undetectable		 4n48A-4i4iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MAL  A 501 (-3.0A)
 0.96A 4n48A-4ifpA:
undetectable		 4n48A-4ifpA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MAL  A 501 (-3.1A)
 1.00A 4n48A-4ikmA:
undetectable		 4n48A-4ikmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Escherichia
coli;
Danio rerio) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MTT  A 501 (-3.0A)
 0.94A 4n48A-4irlA:
undetectable		 4n48A-4irlA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
 0.98A 4n48A-4kegA:
undetectable		 4n48A-4kegA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkr RBMA PROTEIN

(Vibrio cholerae) 		no annotation 4 ASN A 192
ALA A 198
ASP A 126
ASP A 255
 None
 0.97A 4n48A-4kkrA:
undetectable		 4n48A-4kkrA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 ASN A 402
ALA A 243
GLY A 242
ASP A 196
 None
 0.89A 4n48A-4lglA:
2.2		 4n48A-4lglA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 ASN A 269
ALA A  53
GLY A  58
ASP A  16
 None
 0.98A 4n48A-4logA:
undetectable		 4n48A-4logA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		4 ALA A  58
GLY A 131
ASP A 291
ASP A 104
 PO4  A 401 (-3.2A)
None
None
PO4  A 401 (-3.1A)
 1.00A 4n48A-4lvqA:
undetectable		 4n48A-4lvqA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9x CELL DEATH PROTEIN 4

(Caenorhabditis
elegans) 		PF00619
(CARD)
PF00931
(NB-ARC) 		4 ASN A 329
ALA A 331
GLY A 162
ASP A 138
 None
ATP  A 602 (-3.7A)
ATP  A 602 (-3.6A)
None
 0.99A 4n48A-4m9xA:
undetectable		 4n48A-4m9xA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		4 ASN A  56
ALA A  54
GLY A 103
ASP A 240
 None
 0.94A 4n48A-4madA:
undetectable		 4n48A-4madA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF00007
(Cys_knot)
PF13416
(SBP_bac_8) 		4 ASN A 269
ALA A  53
GLY A  58
ASP A  16
 None
None
None
MAL  A1201 (-3.0A)
 0.96A 4n48A-4my2A:
undetectable		 4n48A-4my2A:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		5 ASN A 234
ALA A 236
GLY A 282
ASP A 335
ASP A 364
 SAM  A 601 (-3.3A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
 0.19A 4n48A-4n49A:
68.2		 4n48A-4n49A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe2 MALTOSE ABC
TRANSPORTER
PERIPLASMIC
PROTEIN,PREPILIN-TYP
E N-TERMINAL
CLEAVAGE/METHYLATION
DOMAIN PROTEIN

(Escherichia
coli;
Clostridioides
difficile) 		PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MAL  A 601 (-3.1A)
 0.98A 4n48A-4pe2A:
undetectable		 4n48A-4pe2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA

(Escherichia
coli;
Mus musculus) 		PF13416
(SBP_bac_8)
PF13621
(Cupin_8) 		4 ASN A-104
ALA A-320
GLY A-315
ASP A-357
 None
None
None
GLC  A 901 (-2.9A)
 1.01A 4n48A-4qszA:
undetectable		 4n48A-4qszA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF01648
(ACPS)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MAL  A 601 (-3.1A)
 1.00A 4n48A-4qvhA:
undetectable		 4n48A-4qvhA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1

(Escherichia
coli;
Rattus
norvegicus) 		PF03359
(GKAP)
PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
 0.93A 4n48A-4r0yA:
undetectable		 4n48A-4r0yA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		4 ASN A 269
ALA A  53
GLY A  58
ASP A  16
 None
None
None
MAL  A2201 (-3.0A)
 0.97A 4n48A-4rwfA:
undetectable		 4n48A-4rwfA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		4 ASN A  74
GLY A  54
ASP A 135
ASP A  13
 DDZ  A  53 ( 4.2A)
DDZ  A  53 ( 2.4A)
None
ZN  A1576 (-2.1A)
 1.01A 4n48A-4upiA:
undetectable		 4n48A-4upiA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xai MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TAILLESS
ORTHOLOG

(Escherichia
coli;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 ASN A 269
ALA A  53
GLY A  58
ASP A  16
 None
None
None
MAL  A1401 (-3.2A)
 1.01A 4n48A-4xaiA:
undetectable		 4n48A-4xaiA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaj MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR
RECEPTOR SUBFAMILY 2
GROUP E MEMBER 1

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 ASN A 269
ALA A  53
GLY A  58
ASP A  16
 None
None
None
MAL  A1900 (-3.2A)
 0.95A 4n48A-4xajA:
undetectable		 4n48A-4xajA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT ALPHA

(Yersinia
enterocolitica) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ALA C  10
GLY C  14
ASP C 401
ASP C  19
 None
 1.01A 4n48A-4z42C:
undetectable		 4n48A-4z42C:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE

(Helicobacter
pylori) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 ALA A 366
GLY A 284
ASP A 356
ASP A 364
 None
 0.90A 4n48A-4zi6A:
undetectable		 4n48A-4zi6A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MAL  A 901 (-2.9A)
 0.98A 4n48A-5azaA:
undetectable		 4n48A-5azaA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MALTOSE-BIND
ING PERIPLASMIC
PROTEIN,PILA FUSION
PROTEIN

(Escherichia
coli;
Acinetobacter
nosocomialis) 		PF00114
(Pilin)
PF01547
(SBP_bac_1) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MAL  A1201 (-3.0A)
 0.97A 4n48A-5cfvA:
undetectable		 4n48A-5cfvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASN A 217
ALA A 224
GLY A 226
ASP A  83
 None
 0.89A 4n48A-5fr8A:
undetectable		 4n48A-5fr8A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ALA C   9
GLY C  13
ASP C 399
ASP C  18
 None
 0.94A 4n48A-5fseC:
undetectable		 4n48A-5fseC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Escherichia
coli;
Danio rerio) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MAL  A 501 (-3.1A)
 0.99A 4n48A-5gpqA:
undetectable		 4n48A-5gpqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MTT  A 501 (-3.1A)
 0.97A 4n48A-5h7nA:
undetectable		 4n48A-5h7nA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz7 COMP

(Neisseria
meningitidis) 		PF13416
(SBP_bac_8)
PF16732
(ComP_DUS) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MLR  A 501 (-2.2A)
 0.97A 4n48A-5hz7A:
undetectable		 4n48A-5hz7A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		4 ASN A3934
ALA A3718
GLY A3723
ASP A3681
 None
None
None
MAL  A4201 (-2.6A)
 0.96A 4n48A-5ii5A:
undetectable		 4n48A-5ii5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		4 ASN A4236
ALA A4020
GLY A4025
ASP A3983
 None
None
None
MAL  A4501 (-3.0A)
 1.01A 4n48A-5iicA:
undetectable		 4n48A-5iicA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 4 ASN B 653
ALA B 649
GLY B 329
ASP B 758
 None
 0.95A 4n48A-5iz5B:
undetectable		 4n48A-5iz5B:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE

(Escherichia
coli;
Homo sapiens) 		no annotation 4 ASN C 267
ALA C  51
GLY C  56
ASP C  14
 None
None
None
MTT  C1203 (-3.2A)
 0.99A 4n48A-5jj4C:
undetectable		 4n48A-5jj4C:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8) 		PF11991
(Trp_DMAT) 		4 ASN A 183
ALA A 185
GLY A 160
ASP A 317
 None
 1.00A 4n48A-5jxmA:
undetectable		 4n48A-5jxmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 ASN A1267
ALA A  51
GLY A  56
ASP A  14
 None
 0.97A 4n48A-5k94A:
undetectable		 4n48A-5k94A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3

(Escherichia
coli;
Mus musculus) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MAL  A 501 (-2.5A)
 0.99A 4n48A-5osqA:
undetectable		 4n48A-5osqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio rerio) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
GLC  A1412 ( 3.0A)
 0.98A 4n48A-5t03A:
undetectable		 4n48A-5t03A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MAL  A1501 (-3.2A)
 0.96A 4n48A-5tj2A:
undetectable		 4n48A-5tj2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Brucella canis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ASN A 243
ALA A 245
GLY A 252
ASP A 429
 None
 0.97A 4n48A-5u2aA:
1.7		 4n48A-5u2aA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		PF16679
(CDT1_C) 		4 ALA 8 237
GLY 8 242
ASP 8 216
ASP 8  41
 None
 0.93A 4n48A-5udb8:
undetectable		 4n48A-5udb8:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq6 MBP TAGGED HMNDA-PYD

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MAL  A 501 (-2.9A)
 0.93A 4n48A-5wq6A:
undetectable		 4n48A-5wq6A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE

(Escherichia
coli;
Serratia
marcescens) 		no annotation 4 ASN A 269
ALA A  53
GLY A  58
ASP A  16
 None
None
None
SO4  A 601 ( 4.0A)
 1.00A 4n48A-5wvmA:
undetectable		 4n48A-5wvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xr2 PROTEIN/NUCLEIC ACID
DEGLYCASE HCHA

(Staphylococcus
aureus) 		no annotation 4 ASN A  77
ALA A  60
GLY A  76
ASP A 218
 None
 0.89A 4n48A-5xr2A:
2.7		 4n48A-5xr2A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 4 ALA A 719
GLY A 722
ASP A 737
ASP A 727
 None
 1.00A 4n48A-5yp3A:
1.6		 4n48A-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage JBD30) 		no annotation 4 ASN A 347
ALA A 131
GLY A 136
ASP A  94
 None
None
None
MTT  A 501 ( 3.0A)
 1.00A 4n48A-6anvA:
undetectable		 4n48A-6anvA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dm8 -

(-) 		no annotation 4 ASN A  52
ALA A-164
GLY A-159
ASP A-201
 None
None
None
MAL  A 402 (-3.1A)
 0.98A 4n48A-6dm8A:
undetectable		 4n48A-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 ASN A  82
ALA A 111
GLY A  87
ASP A 184
 None
 0.81A 4n48A-6evgA:
undetectable		 4n48A-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhf -

(-) 		no annotation 4 ASN A 336
ALA A 280
GLY A 340
ASP A 342
 None
 0.94A 4n48A-6fhfA:
undetectable		 4n48A-6fhfA:
undetectable