SIMILAR PATTERNS OF AMINO ACIDS FOR 4N48_A_SAMA601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxn PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN)


(Cupriavidus
necator)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 GLY A 324
PRO A 154
GLY A 153
PHE A 151
LEU A 295
None
1.22A 4n48A-1bxnA:
undetectable
4n48A-1bxnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE


(Triticum
aestivum)
PF00709
(Adenylsucc_synt)
5 GLY A  52
GLY A  53
ILE A 265
GLY A 239
LEU A  24
None
1.18A 4n48A-1dj3A:
undetectable
4n48A-1dj3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1


(Paracoccus
denitrificans)
PF01011
(PQQ)
PF13360
(PQQ_2)
5 GLY A 240
GLY A 182
THR A 277
ASN A 261
GLY A 258
None
None
None
CA  A 702 (-3.1A)
None
1.09A 4n48A-1lrwA:
undetectable
4n48A-1lrwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi0 HYPOTHETICAL PROTEIN
AF2198


(Archaeoglobus
fulgidus)
PF14464
(Prok-JAB)
5 GLY A  67
GLY A  91
ILE A  14
THR A  13
LEU A  10
None
1.28A 4n48A-1oi0A:
undetectable
4n48A-1oi0A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE


(Haemophilus
influenzae)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 GLY A  27
GLY A  25
PHE A  23
THR A 130
GLY A  33
EPU  A 598 (-3.7A)
EPU  A 598 (-3.5A)
None
None
None
1.12A 4n48A-1p31A:
undetectable
4n48A-1p31A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pek PROTEINASE K

(Parengyodontium
album)
PF00082
(Peptidase_S8)
5 GLY E  75
GLY E  78
THR E 211
ILE E 213
GLY E  70
None
0.99A 4n48A-1pekE:
2.5
4n48A-1pekE:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III


(Schizosaccharomyces
pombe)
PF00291
(PALP)
5 GLY A 190
GLY A 162
PHE A  56
GLY A 185
LEU A 242
None
None
PLP  A 350 (-4.7A)
PLP  A 350 (-3.4A)
None
1.07A 4n48A-1v71A:
2.2
4n48A-1v71A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A 320
GLY A 318
ILE A 188
GLY A 159
LEU A 163
NAP  A 801 ( 3.3A)
GOL  A 820 ( 3.8A)
None
CL  A 816 ( 3.1A)
None
1.27A 4n48A-1yb5A:
6.8
4n48A-1yb5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 GLY A 315
PRO A 148
GLY A 147
PHE A 145
LEU A 276
None
1.29A 4n48A-1ykwA:
undetectable
4n48A-1ykwA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE


(Homo sapiens)
PF13561
(adh_short_C2)
5 GLY A 108
GLY A 109
THR A  24
ILE A  47
GLY A  31
None
0.96A 4n48A-1yxmA:
7.4
4n48A-1yxmA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY


(Thermotoga
maritima)
PF00294
(PfkB)
5 GLY A  39
THR A   6
LEU A   7
ASN A   8
ILE A 140
ACT  A 321 ( 4.3A)
None
None
None
None
1.19A 4n48A-2ajrA:
3.7
4n48A-2ajrA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1


(Homo sapiens)
PF03178
(CPSF_A)
PF10433
(MMS1_N)
5 CYH A  87
GLY A 106
ASN A 107
ILE A  79
GLY A1066
None
1.23A 4n48A-2b5mA:
undetectable
4n48A-2b5mA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bcc UBIQUINOL CYTOCHROME
C OXIDOREDUCTASE


(Gallus gallus)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
5 GLY A 259
PRO A 260
GLY A 261
THR A 156
LEU A 153
None
0.86A 4n48A-2bccA:
undetectable
4n48A-2bccA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdu NADPH OXIDASE

(Lactobacillus
sanfranciscensis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 CYH A 242
GLY A 244
ILE A 240
GLY A 161
LEU A 164
None
ADP  A 501 (-3.0A)
None
None
None
1.07A 4n48A-2cduA:
2.5
4n48A-2cduA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL


(Sus scrofa)
PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2)
5 GLY B 328
ASN B 360
ILE B 339
THR B 340
LEU B 368
None
1.11A 4n48A-2fpgB:
undetectable
4n48A-2fpgB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI


(Haemophilus
haemolyticus)
PF00145
(DNA_methylase)
5 GLY A  20
GLY A  22
PHE A  24
ILE A  61
THR A  62
SAH  A 328 (-3.3A)
None
SAH  A 328 (-4.8A)
SAH  A 328 (-4.3A)
SAH  A 328 ( 4.3A)
0.59A 4n48A-2i9kA:
6.9
4n48A-2i9kA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE


(Lactococcus
lactis)
PF02733
(Dak1)
5 GLY A 259
GLY A 261
ILE A 231
GLY A 186
LEU A 235
None
1.03A 4n48A-2iu4A:
undetectable
4n48A-2iu4A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes)
PF00534
(Glycos_transf_1)
5 GLY A  64
GLY A  81
LEU A  18
ASN A  20
LEU A  75
None
0.88A 4n48A-2iuyA:
undetectable
4n48A-2iuyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H


(Escherichia
coli)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
5 GLY X 113
GLY X 111
THR X 116
ASN X 114
GLY X 107
None
2MD  X 801 (-3.8A)
None
None
None
1.15A 4n48A-2iv2X:
undetectable
4n48A-2iv2X:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgv TAGATOSE-6-PHOSPHATE
KINASE


(Staphylococcus
aureus)
PF00294
(PfkB)
5 GLY A  36
THR A   6
LEU A   7
ASN A   8
ILE A 133
None
1.30A 4n48A-2jgvA:
3.7
4n48A-2jgvA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU


(Mycobacterium
tuberculosis)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
5 GLY A  15
PRO A  16
GLY A  17
LEU A  56
GLY A 113
None
1.23A 4n48A-2qkxA:
undetectable
4n48A-2qkxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA


(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
5 GLY B 160
PRO B 161
LEU A   9
ILE A  24
LEU A  50
None
1.01A 4n48A-2v4jB:
undetectable
4n48A-2v4jB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vug PAB1020

(Pyrococcus
abyssi)
PF09414
(RNA_ligase)
5 GLY A  55
GLY A 116
LEU A  52
GLY A  31
LEU A  26
None
1.01A 4n48A-2vugA:
undetectable
4n48A-2vugA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa2 NON-STRUCTURAL
PROTEIN 5


(Modoc virus)
PF01728
(FtsJ)
5 GLY A  84
GLY A  86
THR A 105
LEU A 106
THR A 134
SAM  A1248 (-3.4A)
SAM  A1248 (-4.4A)
SAM  A1248 (-4.5A)
SAM  A1248 (-4.1A)
SAM  A1248 (-3.8A)
0.79A 4n48A-2wa2A:
16.6
4n48A-2wa2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zau SELENIDE, WATER
DIKINASE


(Aquifex
aeolicus)
PF00586
(AIRS)
PF02769
(AIRS_C)
5 GLY A 296
GLY A 297
ILE A  62
THR A  63
GLY A 222
None
1.17A 4n48A-2zauA:
undetectable
4n48A-2zauA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE


(Geobacillus
stearothermophilus)
PF00115
(COX1)
5 GLY A 411
GLY A 407
ASN A 413
GLY A  80
LEU A  81
None
1.24A 4n48A-3ayfA:
undetectable
4n48A-3ayfA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brn LIPOCALIN

(Argas
monolakensis)
PF02098
(His_binding)
5 GLY A  21
PRO A  22
GLY A  23
ILE A  82
THR A  95
None
None
None
SRO  A 158 (-4.4A)
SRO  A 158 ( 4.1A)
1.13A 4n48A-3brnA:
undetectable
4n48A-3brnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5l REGULATORY PROTEIN
RECX


(Lactobacillus
reuteri)
PF02631
(RecX)
5 GLY A 126
PRO A 127
GLY A 128
LEU A 124
LEU A 167
None
0.81A 4n48A-3d5lA:
undetectable
4n48A-3d5lA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evc RNA-DIRECTED RNA
POLYMERASE NS5


(Yellow fever
virus)
PF01728
(FtsJ)
5 GLY A  83
GLY A  85
THR A 104
LEU A 105
ILE A 132
SAH  A 901 (-3.3A)
SAH  A 901 ( 4.4A)
SAH  A 901 (-4.5A)
SAH  A 901 (-4.0A)
SAH  A 901 (-3.8A)
0.63A 4n48A-3evcA:
16.4
4n48A-3evcA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7o SERINE PROTEASE

(Purpureocillium
lilacinum)
PF00082
(Peptidase_S8)
5 GLY A  78
GLY A  81
THR A 214
ILE A 216
GLY A  73
None
1.05A 4n48A-3f7oA:
2.7
4n48A-3f7oA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9i 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Rickettsia
prowazekii)
PF13561
(adh_short_C2)
5 GLY A 138
GLY A 144
ILE A 201
THR A 205
GLY A 179
None
0.94A 4n48A-3f9iA:
6.8
4n48A-3f9iA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9i 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Rickettsia
prowazekii)
PF13561
(adh_short_C2)
5 GLY A 141
GLY A 144
ILE A 201
THR A 205
GLY A 179
None
1.29A 4n48A-3f9iA:
6.8
4n48A-3f9iA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN


(Novosphingobium
aromaticivorans)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A  96
GLY A 103
ILE A 136
GLY A  93
LEU A 285
None
1.10A 4n48A-3gazA:
6.8
4n48A-3gazA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghy KETOPANTOATE
REDUCTASE PROTEIN


(Ralstonia
solanacearum)
PF02558
(ApbA)
PF08546
(ApbA_C)
5 CYH A  97
GLY A  95
PRO A  94
GLY A  93
ILE A 180
None
0.94A 4n48A-3ghyA:
3.2
4n48A-3ghyA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE


(Bartonella
henselae)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
5 GLY A  91
THR A 190
ILE A 202
GLY A 172
LEU A 165
None
1.03A 4n48A-3girA:
undetectable
4n48A-3girA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE


(Bartonella
henselae)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
5 GLY A 180
GLY A  91
ILE A 202
GLY A 172
LEU A 165
None
1.08A 4n48A-3girA:
undetectable
4n48A-3girA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1


(Schizosaccharomyces
pombe)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
5 GLY A 407
PRO A 406
ASN A 400
ILE A 411
LEU A 432
None
0.95A 4n48A-3h0gA:
undetectable
4n48A-3h0gA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I


(Gallus gallus)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
5 GLY A 259
PRO A 260
GLY A 261
THR A 156
LEU A 153
None
0.89A 4n48A-3h1lA:
undetectable
4n48A-3h1lA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8t HMUY

(Porphyromonas
gingivalis)
PF14064
(HmuY)
5 GLY A 184
GLY A 187
ASN A  85
ILE A 147
THR A 148
None
1.23A 4n48A-3h8tA:
undetectable
4n48A-3h8tA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA


(Moorella
thermoacetica)
PF03063
(Prismane)
5 GLY A  85
PRO A  84
GLY A  83
ILE A  97
GLY A  91
None
1.15A 4n48A-3i04A:
3.0
4n48A-3i04A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN


(Ruegeria
pomeroyi)
PF00497
(SBP_bac_3)
5 GLY A  75
PHE A  76
THR A  57
ILE A 114
GLY A 117
None
1.21A 4n48A-3i6vA:
undetectable
4n48A-3i6vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN


(Ruegeria
pomeroyi)
PF00497
(SBP_bac_3)
5 GLY A 239
PHE A 241
ILE A 120
THR A 121
GLY A 229
None
None
GOL  A 280 (-4.6A)
None
None
0.97A 4n48A-3i6vA:
undetectable
4n48A-3i6vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN


(Neisseria
gonorrhoeae)
PF00588
(SpoU_methylase)
5 GLY A 145
GLY A 150
THR A  20
ILE A  45
LEU A  43
None
1.14A 4n48A-3ic6A:
undetectable
4n48A-3ic6A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 CYH A 280
GLY A 291
GLY A 292
GLY A 123
LEU A 182
None
1.29A 4n48A-3ll3A:
undetectable
4n48A-3ll3A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqt MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Shewanella
pealeana)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 CYH A 286
GLY A  98
THR A 262
GLY A 288
LEU A 292
None
1.10A 4n48A-3mqtA:
undetectable
4n48A-3mqtA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzg PUTATIVE RACEMASE

(Pseudovibrio
sp. JE062)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 CYH A 291
GLY A 103
THR A 267
GLY A 293
LEU A 297
None
1.13A 4n48A-3nzgA:
undetectable
4n48A-3nzgA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovg AMIDOHYDROLASE

(Mycoplasma
synoviae)
PF02126
(PTE)
5 GLY A  19
THR A  21
ILE A  64
THR A  66
GLY A  91
None
1.14A 4n48A-3ovgA:
undetectable
4n48A-3ovgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT


(Cryptococcus
neoformans)
PF00432
(Prenyltrans)
5 GLY B 267
GLY B 316
PHE B 314
THR B 270
GLY B 333
None
FII  B 522 ( 4.6A)
None
None
None
1.25A 4n48A-3q75B:
undetectable
4n48A-3q75B:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica)
PF00291
(PALP)
5 GLY A 283
GLY A 281
THR A  43
GLY A 288
LEU A 291
None
SO4  A 449 (-3.3A)
None
None
None
1.25A 4n48A-3r0zA:
2.0
4n48A-3r0zA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica)
PF00291
(PALP)
6 GLY A 283
PRO A 282
GLY A 280
LEU A 354
GLY A 288
LEU A 291
None
SO4  A 449 (-4.3A)
SO4  A 449 (-3.6A)
None
None
None
1.15A 4n48A-3r0zA:
2.0
4n48A-3r0zA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica)
PF00291
(PALP)
5 GLY A 283
PRO A 282
GLY A 281
GLY A 288
LEU A 291
None
SO4  A 449 (-4.3A)
SO4  A 449 (-3.3A)
None
None
1.04A 4n48A-3r0zA:
2.0
4n48A-3r0zA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r50 IPOMOELIN

(Ipomoea batatas)
PF01419
(Jacalin)
5 GLY A 148
GLY A  14
ILE A  84
GLY A 135
LEU A  32
None
0.98A 4n48A-3r50A:
undetectable
4n48A-3r50A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slu M23 PEPTIDASE DOMAIN
PROTEIN


(Neisseria
meningitidis)
PF01551
(Peptidase_M23)
5 GLY A 119
GLY A 115
ILE A  91
THR A  92
LEU A  78
None
1.06A 4n48A-3sluA:
undetectable
4n48A-3sluA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE


(Mycobacterium
ulcerans)
PF13561
(adh_short_C2)
5 GLY A  18
ILE A  68
THR A  69
GLY A  96
LEU A 118
None
1.16A 4n48A-3svtA:
7.7
4n48A-3svtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tav METHIONINE
AMINOPEPTIDASE


(Mycobacteroides
abscessus)
PF00557
(Peptidase_M24)
5 GLY A 114
GLY A 106
THR A 250
LEU A 261
GLY A 187
None
0.98A 4n48A-3tavA:
undetectable
4n48A-3tavA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucx SHORT CHAIN
DEHYDROGENASE


(Mycolicibacterium
smegmatis)
PF13561
(adh_short_C2)
5 GLY A  16
PRO A  17
ILE A  65
THR A  66
LEU A 115
CL  A 261 (-3.2A)
CL  A 261 ( 4.7A)
None
None
None
1.06A 4n48A-3ucxA:
6.9
4n48A-3ucxA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9a PUTATIVE
UNCHARACTERIZED
PROTEIN


(Coprinopsis
cinerea)
no annotation 5 GLY A 243
PRO A 244
GLY A  19
ILE A 181
GLY A 110
None
1.15A 4n48A-3w9aA:
undetectable
4n48A-3w9aA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pyrococcus
furiosus)
PF01554
(MatE)
5 GLY A 158
GLY A 156
ILE A  85
GLY A 164
LEU A  12
None
0.66A 4n48A-3wbnA:
undetectable
4n48A-3wbnA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwp (S)-HYDROXYNITRILE
LYASE


(Baliospermum
montanum)
PF00561
(Abhydrolase_1)
5 GLY A  81
GLY A  83
ILE A 157
THR A 152
LEU A 148
None
None
CL  A 309 ( 4.0A)
None
None
1.00A 4n48A-3wwpA:
undetectable
4n48A-3wwpA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE


(Methylophilus
methylotrophus)
PF13360
(PQQ_2)
5 GLY A 234
GLY A 176
THR A 271
ASN A 255
GLY A 252
None
None
None
CA  A 702 ( 3.0A)
None
1.02A 4n48A-4aahA:
undetectable
4n48A-4aahA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF13561
(adh_short_C2)
5 GLY A  21
ILE A  62
THR A  63
GLY A  86
LEU A 105
None
1.06A 4n48A-4avyA:
6.9
4n48A-4avyA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF13561
(adh_short_C2)
5 GLY A  21
LEU A  42
ILE A  62
THR A  63
LEU A 105
None
1.09A 4n48A-4avyA:
6.9
4n48A-4avyA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ber PHOSPHOCHOLINE
TRANSFERASE ANKX


(Legionella
pneumophila)
PF02661
(Fic)
PF12796
(Ank_2)
5 PRO A   9
GLY A  10
ASN A   7
ILE A  59
LEU A  76
None
0.86A 4n48A-4berA:
undetectable
4n48A-4berA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)


(Legionella
pneumophila)
PF00351
(Biopterin_H)
5 GLY A 183
GLY A 181
PHE A  47
ILE A 188
LEU A  31
None
1.17A 4n48A-4bptA:
undetectable
4n48A-4bptA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxw FACTOR XA

(Pseudonaja
textilis)
PF00089
(Trypsin)
PF14670
(FXa_inhibition)
5 GLY A 364
PRO A 365
LEU A 187
THR A 216
GLY A 360
None
None
None
None
0GJ  A1411 (-3.8A)
1.27A 4n48A-4bxwA:
undetectable
4n48A-4bxwA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbz DELTARHODOPSIN

(Haloterrigena
thermotolerans)
PF01036
(Bac_rhodopsin)
5 GLY A  30
THR A  46
ILE A  48
THR A  88
GLY A 220
22B  A 302 (-3.6A)
22B  A 302 (-3.9A)
None
RET  A 301 ( 4.6A)
None
1.24A 4n48A-4fbzA:
undetectable
4n48A-4fbzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr6 LECTIN

(Trichosanthes
anguina)
PF00652
(Ricin_B_lectin)
5 GLY C  52
PHE C  48
ASN C  97
ILE C  74
LEU C  33
None
1.25A 4n48A-4hr6C:
undetectable
4n48A-4hr6C:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE


(Toxoplasma
gondii)
PF00316
(FBPase)
5 GLY A 160
PRO A 161
ILE A  37
GLY A 122
LEU A 109
None
1.12A 4n48A-4ir8A:
undetectable
4n48A-4ir8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6o METALLOPHOSPHOESTERA
SE


(Ruminiclostridium
thermocellum)
PF00149
(Metallophos)
5 GLY A 274
LEU A 272
ASN A 273
THR A 286
LEU A 283
None
1.09A 4n48A-4j6oA:
undetectable
4n48A-4j6oA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A3851
GLY A3838
THR A3874
LEU A3871
LEU A3929
None
1.09A 4n48A-4kc5A:
undetectable
4n48A-4kc5A:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1


(Homo sapiens)
PF01728
(FtsJ)
12 CYH A 277
GLY A 279
PRO A 280
GLY A 281
PHE A 283
THR A 301
LEU A 302
ASN A 306
ILE A 336
THR A 337
GLY A 365
LEU A 383
SAM  A 601 (-3.7A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.5A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
None
SAM  A 601 (-4.1A)
SAM  A 601 ( 3.9A)
SAM  A 601 ( 4.0A)
SAM  A 601 (-4.6A)
0.23A 4n48A-4n49A:
68.2
4n48A-4n49A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1


(Homo sapiens)
PF01728
(FtsJ)
5 PRO A 280
LEU A 302
THR A 337
GLY A 366
LEU A 383
SAM  A 601 (-3.6A)
SAM  A 601 (-4.1A)
SAM  A 601 ( 3.9A)
SAM  A 601 (-4.6A)
SAM  A 601 (-4.6A)
1.10A 4n48A-4n49A:
68.2
4n48A-4n49A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE


(Bacillus
subtilis)
no annotation 5 GLY A 109
PRO A 110
GLY A  66
ASN A 108
ILE A 102
None
1.24A 4n48A-4p8iA:
undetectable
4n48A-4p8iA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis)
PF00294
(PfkB)
5 GLY A  61
GLY A  58
ILE A 319
GLY A 266
LEU A 271
None
0.90A 4n48A-4pvvA:
3.3
4n48A-4pvvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r72 ABC-TYPE FE3+
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT


(Actinobacillus
pleuropneumoniae)
PF13343
(SBP_bac_6)
5 GLY A 225
PHE A 158
LEU A 288
GLY A 108
LEU A 204
None
None
GOL  A 404 (-3.9A)
None
None
0.88A 4n48A-4r72A:
undetectable
4n48A-4r72A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT


(Methylococcus
capsulatus)
no annotation 5 GLY B 268
GLY B 210
THR B 305
ASN B 289
GLY B 286
None
None
None
CA  B 701 ( 2.8A)
None
1.07A 4n48A-4tqoB:
undetectable
4n48A-4tqoB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4who PROTOCATECHUATE
3,4-DIOXYGENASE
ALPHA CHAIN


(Pseudomonas
putida)
PF00775
(Dioxygenase_C)
5 GLY A 112
GLY A  77
ILE A  49
THR A 181
GLY A  46
None
1.02A 4n48A-4whoA:
undetectable
4n48A-4whoA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B


(Caenorhabditis
elegans)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
5 GLY A 320
GLY A 269
ILE A 316
GLY A 325
LEU A 177
None
0.83A 4n48A-4y9lA:
undetectable
4n48A-4y9lA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z38 MLNA

(Bacillus
velezensis)
no annotation 5 GLY A 371
GLY A 351
ASN A 400
GLY A 368
LEU A 367
None
None
FMN  A 900 ( 3.3A)
None
None
1.05A 4n48A-4z38A:
undetectable
4n48A-4z38A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT BETA
UREASE SUBUNIT ALPHA


(Yersinia
enterocolitica;
Yersinia
enterocolitica)
PF00699
(Urease_beta)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
5 GLY B 119
PHE B 118
THR C  73
GLY C  56
LEU C  51
None
1.21A 4n48A-4z42B:
undetectable
4n48A-4z42B:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE


(Neurospora
crassa)
PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1)
5 GLY A 286
PRO A 287
LEU A 258
THR A 246
GLY A 266
None
1.21A 4n48A-4ztxA:
undetectable
4n48A-4ztxA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2z EXFOLIATIVE TOXIN D2

(Staphylococcus
aureus)
PF00089
(Trypsin)
5 GLY A  83
GLY A  71
THR A  93
ILE A 148
LEU A 270
None
1.19A 4n48A-5c2zA:
undetectable
4n48A-5c2zA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dku PREX DNA POLYMERASE

(Plasmodium
falciparum)
PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1)
5 GLY A 549
GLY A 376
PHE A 374
THR A 526
LEU A 527
None
1.29A 4n48A-5dkuA:
undetectable
4n48A-5dkuA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgw EXTRACELLULAR
STREPTODORNASE D


(Streptococcus
pyogenes)
PF01223
(Endonuclease_NS)
5 GLY A 103
GLY A 101
ILE A 204
GLY A 106
LEU A 189
None
1.15A 4n48A-5fgwA:
undetectable
4n48A-5fgwA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1


(Homo sapiens)
PF03178
(CPSF_A)
PF10433
(MMS1_N)
5 CYH A  87
GLY A 106
ASN A 107
ILE A  79
GLY A1066
None
1.25A 4n48A-5fqdA:
undetectable
4n48A-5fqdA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6c URIC ACID-XANTHINE
PERMEASE


(Aspergillus
nidulans)
PF00860
(Xan_ur_permease)
5 GLY A 340
PRO A 341
PHE A 165
THR A 195
GLY A 190
None
1.29A 4n48A-5i6cA:
undetectable
4n48A-5i6cA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifz RIBOSE 5-PHOSPHATE
ISOMERASE


(Brucella
melitensis)
PF02502
(LacAB_rpiB)
5 GLY A  81
GLY A  83
THR A 118
ILE A  75
LEU A  31
None
1.30A 4n48A-5ifzA:
undetectable
4n48A-5ifzA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE


(Bacillus
anthracis)
PF04127
(DFP)
5 GLY A 195
PRO A 196
GLY A 235
ILE A 271
GLY A 216
None
1.03A 4n48A-5intA:
3.3
4n48A-5intA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz3 PREDICTED PROTEIN

(Physcomitrella
patens)
PF00316
(FBPase)
5 GLY B 221
PRO B 222
ILE B 111
GLY B 193
LEU B 180
None
0.99A 4n48A-5iz3B:
undetectable
4n48A-5iz3B:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp5 GALECTIN-5

(Rattus
norvegicus)
PF00337
(Gal-bind_lectin)
5 PRO A 127
GLY A  24
LEU A 123
ILE A  54
GLY A  51
None
0.93A 4n48A-5jp5A:
undetectable
4n48A-5jp5A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA


(Mus musculus)
PF01532
(Glyco_hydro_47)
5 GLY A 481
GLY A 503
THR A 553
ILE A 551
THR A 612
None
1.25A 4n48A-5kkbA:
undetectable
4n48A-5kkbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kss 5'-NUCLEOTIDASE SURE

(Xylella
fastidiosa)
PF01975
(SurE)
5 GLY A 105
THR A  69
THR A  77
GLY A 113
LEU A 116
CL  A 504 ( 4.9A)
None
None
None
None
1.16A 4n48A-5kssA:
undetectable
4n48A-5kssA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN


(Thermothelomyces
thermophila)
PF07992
(Pyr_redox_2)
5 GLY A  90
GLY A  87
PHE A 118
LEU A 220
ILE A  82
None
FAD  A 700 (-3.5A)
None
None
None
0.82A 4n48A-5mq6A:
undetectable
4n48A-5mq6A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu5 UNCHARACTERIZED
PROTEIN


(Magnetospirillum
magneticum)
no annotation 5 GLY A 457
GLY A 461
ASN A 458
THR A 472
GLY A 417
None
CL  A 703 ( 3.7A)
None
None
None
1.16A 4n48A-5mu5A:
undetectable
4n48A-5mu5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa)
no annotation 5 GLY A 438
GLY A 421
ASN A 437
ILE A 442
THR A 448
None
None
NAG  A1129 (-1.9A)
None
None
1.13A 4n48A-5nbsA:
3.0
4n48A-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE


(Fusobacterium
nucleatum)
PF00480
(ROK)
5 GLY A 276
GLY A 279
ILE A  13
THR A  32
GLY A  64
None
1.06A 4n48A-5nckA:
undetectable
4n48A-5nckA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfh SALT STRESS-INDUCED
PROTEIN


(Oryza sativa)
no annotation 5 GLY A 140
GLY A   7
ILE A  75
GLY A 127
LEU A  26
None
0.98A 4n48A-5xfhA:
undetectable
4n48A-5xfhA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN


(Homo sapiens)
PF00415
(RCC1)
PF13540
(RCC1_2)
5 CYH A 294
GLY A 292
GLY A 238
GLY A 308
LEU A 315
None
1.24A 4n48A-5xgsA:
undetectable
4n48A-5xgsA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f74 ALCOHOL OXIDASE

(Thermothelomyces
thermophila)
no annotation 5 GLY A 247
GLY A 229
THR A 250
GLY A 244
LEU A 489
None
FAD  A 601 ( 4.0A)
None
None
None
1.03A 4n48A-6f74A:
undetectable
4n48A-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gkv COCLAURINE
N-METHYLTRANSFERASE


(Coptis japonica)
no annotation 5 GLY A 139
GLY A 141
THR A 160
ILE A 188
THR A 189
SAH  A 501 (-3.1A)
None
SAH  A 501 ( 4.8A)
SAH  A 501 (-3.9A)
None
0.78A 4n48A-6gkvA:
7.4
4n48A-6gkvA:
undetectable