SIMILAR PATTERNS OF AMINO ACIDS FOR 4N48_A_SAMA601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxn PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN)

(Cupriavidus
necator) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLY A 324
PRO A 154
GLY A 153
PHE A 151
LEU A 295
 None
 1.22A 4n48A-1bxnA:
undetectable		 4n48A-1bxnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		5 GLY A  52
GLY A  53
ILE A 265
GLY A 239
LEU A  24
 None
 1.18A 4n48A-1dj3A:
undetectable		 4n48A-1dj3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 GLY A 240
GLY A 182
THR A 277
ASN A 261
GLY A 258
 None
None
None
CA  A 702 (-3.1A)
None
 1.09A 4n48A-1lrwA:
undetectable		 4n48A-1lrwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi0 HYPOTHETICAL PROTEIN
AF2198

(Archaeoglobus
fulgidus) 		PF14464
(Prok-JAB) 		5 GLY A  67
GLY A  91
ILE A  14
THR A  13
LEU A  10
 None
 1.28A 4n48A-1oi0A:
undetectable		 4n48A-1oi0A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE

(Haemophilus
influenzae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 GLY A  27
GLY A  25
PHE A  23
THR A 130
GLY A  33
 EPU  A 598 (-3.7A)
EPU  A 598 (-3.5A)
None
None
None
 1.12A 4n48A-1p31A:
undetectable		 4n48A-1p31A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pek PROTEINASE K

(Parengyodontium
album) 		PF00082
(Peptidase_S8) 		5 GLY E  75
GLY E  78
THR E 211
ILE E 213
GLY E  70
 None
 0.99A 4n48A-1pekE:
2.5		 4n48A-1pekE:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III

(Schizosaccharomyces
pombe) 		PF00291
(PALP) 		5 GLY A 190
GLY A 162
PHE A  56
GLY A 185
LEU A 242
 None
None
PLP  A 350 (-4.7A)
PLP  A 350 (-3.4A)
None
 1.07A 4n48A-1v71A:
2.2		 4n48A-1v71A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 320
GLY A 318
ILE A 188
GLY A 159
LEU A 163
 NAP  A 801 ( 3.3A)
GOL  A 820 ( 3.8A)
None
CL  A 816 ( 3.1A)
None
 1.27A 4n48A-1yb5A:
6.8		 4n48A-1yb5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLY A 315
PRO A 148
GLY A 147
PHE A 145
LEU A 276
 None
 1.29A 4n48A-1ykwA:
undetectable		 4n48A-1ykwA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 GLY A 108
GLY A 109
THR A  24
ILE A  47
GLY A  31
 None
 0.96A 4n48A-1yxmA:
7.4		 4n48A-1yxmA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 GLY A  39
THR A   6
LEU A   7
ASN A   8
ILE A 140
 ACT  A 321 ( 4.3A)
None
None
None
None
 1.19A 4n48A-2ajrA:
3.7		 4n48A-2ajrA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 CYH A  87
GLY A 106
ASN A 107
ILE A  79
GLY A1066
 None
 1.23A 4n48A-2b5mA:
undetectable		 4n48A-2b5mA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bcc UBIQUINOL CYTOCHROME
C OXIDOREDUCTASE

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 GLY A 259
PRO A 260
GLY A 261
THR A 156
LEU A 153
 None
 0.86A 4n48A-2bccA:
undetectable		 4n48A-2bccA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdu NADPH OXIDASE

(Lactobacillus
sanfranciscensis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 CYH A 242
GLY A 244
ILE A 240
GLY A 161
LEU A 164
 None
ADP  A 501 (-3.0A)
None
None
None
 1.07A 4n48A-2cduA:
2.5		 4n48A-2cduA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		5 GLY B 328
ASN B 360
ILE B 339
THR B 340
LEU B 368
 None
 1.11A 4n48A-2fpgB:
undetectable		 4n48A-2fpgB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		5 GLY A  20
GLY A  22
PHE A  24
ILE A  61
THR A  62
 SAH  A 328 (-3.3A)
None
SAH  A 328 (-4.8A)
SAH  A 328 (-4.3A)
SAH  A 328 ( 4.3A)
 0.59A 4n48A-2i9kA:
6.9		 4n48A-2i9kA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 GLY A 259
GLY A 261
ILE A 231
GLY A 186
LEU A 235
 None
 1.03A 4n48A-2iu4A:
undetectable		 4n48A-2iu4A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		5 GLY A  64
GLY A  81
LEU A  18
ASN A  20
LEU A  75
 None
 0.88A 4n48A-2iuyA:
undetectable		 4n48A-2iuyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY X 113
GLY X 111
THR X 116
ASN X 114
GLY X 107
 None
2MD  X 801 (-3.8A)
None
None
None
 1.15A 4n48A-2iv2X:
undetectable		 4n48A-2iv2X:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgv TAGATOSE-6-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 GLY A  36
THR A   6
LEU A   7
ASN A   8
ILE A 133
 None
 1.30A 4n48A-2jgvA:
3.7		 4n48A-2jgvA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 GLY A  15
PRO A  16
GLY A  17
LEU A  56
GLY A 113
 None
 1.23A 4n48A-2qkxA:
undetectable		 4n48A-2qkxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 GLY B 160
PRO B 161
LEU A   9
ILE A  24
LEU A  50
 None
 1.01A 4n48A-2v4jB:
undetectable		 4n48A-2v4jB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vug PAB1020

(Pyrococcus
abyssi) 		PF09414
(RNA_ligase) 		5 GLY A  55
GLY A 116
LEU A  52
GLY A  31
LEU A  26
 None
 1.01A 4n48A-2vugA:
undetectable		 4n48A-2vugA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa2 NON-STRUCTURAL
PROTEIN 5

(Modoc virus) 		PF01728
(FtsJ) 		5 GLY A  84
GLY A  86
THR A 105
LEU A 106
THR A 134
 SAM  A1248 (-3.4A)
SAM  A1248 (-4.4A)
SAM  A1248 (-4.5A)
SAM  A1248 (-4.1A)
SAM  A1248 (-3.8A)
 0.79A 4n48A-2wa2A:
16.6		 4n48A-2wa2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zau SELENIDE, WATER
DIKINASE

(Aquifex
aeolicus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 GLY A 296
GLY A 297
ILE A  62
THR A  63
GLY A 222
 None
 1.17A 4n48A-2zauA:
undetectable		 4n48A-2zauA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		5 GLY A 411
GLY A 407
ASN A 413
GLY A  80
LEU A  81
 None
 1.24A 4n48A-3ayfA:
undetectable		 4n48A-3ayfA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brn LIPOCALIN

(Argas
monolakensis) 		PF02098
(His_binding) 		5 GLY A  21
PRO A  22
GLY A  23
ILE A  82
THR A  95
 None
None
None
SRO  A 158 (-4.4A)
SRO  A 158 ( 4.1A)
 1.13A 4n48A-3brnA:
undetectable		 4n48A-3brnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5l REGULATORY PROTEIN
RECX

(Lactobacillus
reuteri) 		PF02631
(RecX) 		5 GLY A 126
PRO A 127
GLY A 128
LEU A 124
LEU A 167
 None
 0.81A 4n48A-3d5lA:
undetectable		 4n48A-3d5lA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		5 GLY A  83
GLY A  85
THR A 104
LEU A 105
ILE A 132
 SAH  A 901 (-3.3A)
SAH  A 901 ( 4.4A)
SAH  A 901 (-4.5A)
SAH  A 901 (-4.0A)
SAH  A 901 (-3.8A)
 0.63A 4n48A-3evcA:
16.4		 4n48A-3evcA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7o SERINE PROTEASE

(Purpureocillium
lilacinum) 		PF00082
(Peptidase_S8) 		5 GLY A  78
GLY A  81
THR A 214
ILE A 216
GLY A  73
 None
 1.05A 4n48A-3f7oA:
2.7		 4n48A-3f7oA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9i 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Rickettsia
prowazekii) 		PF13561
(adh_short_C2) 		5 GLY A 138
GLY A 144
ILE A 201
THR A 205
GLY A 179
 None
 0.94A 4n48A-3f9iA:
6.8		 4n48A-3f9iA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9i 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Rickettsia
prowazekii) 		PF13561
(adh_short_C2) 		5 GLY A 141
GLY A 144
ILE A 201
THR A 205
GLY A 179
 None
 1.29A 4n48A-3f9iA:
6.8		 4n48A-3f9iA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A  96
GLY A 103
ILE A 136
GLY A  93
LEU A 285
 None
 1.10A 4n48A-3gazA:
6.8		 4n48A-3gazA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghy KETOPANTOATE
REDUCTASE PROTEIN

(Ralstonia
solanacearum) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 CYH A  97
GLY A  95
PRO A  94
GLY A  93
ILE A 180
 None
 0.94A 4n48A-3ghyA:
3.2		 4n48A-3ghyA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE

(Bartonella
henselae) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 GLY A  91
THR A 190
ILE A 202
GLY A 172
LEU A 165
 None
 1.03A 4n48A-3girA:
undetectable		 4n48A-3girA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE

(Bartonella
henselae) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 GLY A 180
GLY A  91
ILE A 202
GLY A 172
LEU A 165
 None
 1.08A 4n48A-3girA:
undetectable		 4n48A-3girA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 GLY A 407
PRO A 406
ASN A 400
ILE A 411
LEU A 432
 None
 0.95A 4n48A-3h0gA:
undetectable		 4n48A-3h0gA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 GLY A 259
PRO A 260
GLY A 261
THR A 156
LEU A 153
 None
 0.89A 4n48A-3h1lA:
undetectable		 4n48A-3h1lA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8t HMUY

(Porphyromonas
gingivalis) 		PF14064
(HmuY) 		5 GLY A 184
GLY A 187
ASN A  85
ILE A 147
THR A 148
 None
 1.23A 4n48A-3h8tA:
undetectable		 4n48A-3h8tA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		5 GLY A  85
PRO A  84
GLY A  83
ILE A  97
GLY A  91
 None
 1.15A 4n48A-3i04A:
3.0		 4n48A-3i04A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00497
(SBP_bac_3) 		5 GLY A  75
PHE A  76
THR A  57
ILE A 114
GLY A 117
 None
 1.21A 4n48A-3i6vA:
undetectable		 4n48A-3i6vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00497
(SBP_bac_3) 		5 GLY A 239
PHE A 241
ILE A 120
THR A 121
GLY A 229
 None
None
GOL  A 280 (-4.6A)
None
None
 0.97A 4n48A-3i6vA:
undetectable		 4n48A-3i6vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN

(Neisseria
gonorrhoeae) 		PF00588
(SpoU_methylase) 		5 GLY A 145
GLY A 150
THR A  20
ILE A  45
LEU A  43
 None
 1.14A 4n48A-3ic6A:
undetectable		 4n48A-3ic6A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 CYH A 280
GLY A 291
GLY A 292
GLY A 123
LEU A 182
 None
 1.29A 4n48A-3ll3A:
undetectable		 4n48A-3ll3A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqt MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 CYH A 286
GLY A  98
THR A 262
GLY A 288
LEU A 292
 None
 1.10A 4n48A-3mqtA:
undetectable		 4n48A-3mqtA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzg PUTATIVE RACEMASE

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 CYH A 291
GLY A 103
THR A 267
GLY A 293
LEU A 297
 None
 1.13A 4n48A-3nzgA:
undetectable		 4n48A-3nzgA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovg AMIDOHYDROLASE

(Mycoplasma
synoviae) 		PF02126
(PTE) 		5 GLY A  19
THR A  21
ILE A  64
THR A  66
GLY A  91
 None
 1.14A 4n48A-3ovgA:
undetectable		 4n48A-3ovgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		5 GLY B 267
GLY B 316
PHE B 314
THR B 270
GLY B 333
 None
FII  B 522 ( 4.6A)
None
None
None
 1.25A 4n48A-3q75B:
undetectable		 4n48A-3q75B:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 GLY A 283
GLY A 281
THR A  43
GLY A 288
LEU A 291
 None
SO4  A 449 (-3.3A)
None
None
None
 1.25A 4n48A-3r0zA:
2.0		 4n48A-3r0zA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica) 		PF00291
(PALP) 		6 GLY A 283
PRO A 282
GLY A 280
LEU A 354
GLY A 288
LEU A 291
 None
SO4  A 449 (-4.3A)
SO4  A 449 (-3.6A)
None
None
None
 1.15A 4n48A-3r0zA:
2.0		 4n48A-3r0zA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 GLY A 283
PRO A 282
GLY A 281
GLY A 288
LEU A 291
 None
SO4  A 449 (-4.3A)
SO4  A 449 (-3.3A)
None
None
 1.04A 4n48A-3r0zA:
2.0		 4n48A-3r0zA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r50 IPOMOELIN

(Ipomoea batatas) 		PF01419
(Jacalin) 		5 GLY A 148
GLY A  14
ILE A  84
GLY A 135
LEU A  32
 None
 0.98A 4n48A-3r50A:
undetectable		 4n48A-3r50A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slu M23 PEPTIDASE DOMAIN
PROTEIN

(Neisseria
meningitidis) 		PF01551
(Peptidase_M23) 		5 GLY A 119
GLY A 115
ILE A  91
THR A  92
LEU A  78
 None
 1.06A 4n48A-3sluA:
undetectable		 4n48A-3sluA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
ulcerans) 		PF13561
(adh_short_C2) 		5 GLY A  18
ILE A  68
THR A  69
GLY A  96
LEU A 118
 None
 1.16A 4n48A-3svtA:
7.7		 4n48A-3svtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tav METHIONINE
AMINOPEPTIDASE

(Mycobacteroides
abscessus) 		PF00557
(Peptidase_M24) 		5 GLY A 114
GLY A 106
THR A 250
LEU A 261
GLY A 187
 None
 0.98A 4n48A-3tavA:
undetectable		 4n48A-3tavA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucx SHORT CHAIN
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 GLY A  16
PRO A  17
ILE A  65
THR A  66
LEU A 115
 CL  A 261 (-3.2A)
CL  A 261 ( 4.7A)
None
None
None
 1.06A 4n48A-3ucxA:
6.9		 4n48A-3ucxA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Coprinopsis
cinerea) 		no annotation 5 GLY A 243
PRO A 244
GLY A  19
ILE A 181
GLY A 110
 None
 1.15A 4n48A-3w9aA:
undetectable		 4n48A-3w9aA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01554
(MatE) 		5 GLY A 158
GLY A 156
ILE A  85
GLY A 164
LEU A  12
 None
 0.66A 4n48A-3wbnA:
undetectable		 4n48A-3wbnA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwp (S)-HYDROXYNITRILE
LYASE

(Baliospermum
montanum) 		PF00561
(Abhydrolase_1) 		5 GLY A  81
GLY A  83
ILE A 157
THR A 152
LEU A 148
 None
None
CL  A 309 ( 4.0A)
None
None
 1.00A 4n48A-3wwpA:
undetectable		 4n48A-3wwpA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF13360
(PQQ_2) 		5 GLY A 234
GLY A 176
THR A 271
ASN A 255
GLY A 252
 None
None
None
CA  A 702 ( 3.0A)
None
 1.02A 4n48A-4aahA:
undetectable		 4n48A-4aahA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		5 GLY A  21
ILE A  62
THR A  63
GLY A  86
LEU A 105
 None
 1.06A 4n48A-4avyA:
6.9		 4n48A-4avyA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		5 GLY A  21
LEU A  42
ILE A  62
THR A  63
LEU A 105
 None
 1.09A 4n48A-4avyA:
6.9		 4n48A-4avyA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ber PHOSPHOCHOLINE
TRANSFERASE ANKX

(Legionella
pneumophila) 		PF02661
(Fic)
PF12796
(Ank_2) 		5 PRO A   9
GLY A  10
ASN A   7
ILE A  59
LEU A  76
 None
 0.86A 4n48A-4berA:
undetectable		 4n48A-4berA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)

(Legionella
pneumophila) 		PF00351
(Biopterin_H) 		5 GLY A 183
GLY A 181
PHE A  47
ILE A 188
LEU A  31
 None
 1.17A 4n48A-4bptA:
undetectable		 4n48A-4bptA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxw FACTOR XA

(Pseudonaja
textilis) 		PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		5 GLY A 364
PRO A 365
LEU A 187
THR A 216
GLY A 360
 None
None
None
None
0GJ  A1411 (-3.8A)
 1.27A 4n48A-4bxwA:
undetectable		 4n48A-4bxwA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbz DELTARHODOPSIN

(Haloterrigena
thermotolerans) 		PF01036
(Bac_rhodopsin) 		5 GLY A  30
THR A  46
ILE A  48
THR A  88
GLY A 220
 22B  A 302 (-3.6A)
22B  A 302 (-3.9A)
None
RET  A 301 ( 4.6A)
None
 1.24A 4n48A-4fbzA:
undetectable		 4n48A-4fbzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr6 LECTIN

(Trichosanthes
anguina) 		PF00652
(Ricin_B_lectin) 		5 GLY C  52
PHE C  48
ASN C  97
ILE C  74
LEU C  33
 None
 1.25A 4n48A-4hr6C:
undetectable		 4n48A-4hr6C:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE

(Toxoplasma
gondii) 		PF00316
(FBPase) 		5 GLY A 160
PRO A 161
ILE A  37
GLY A 122
LEU A 109
 None
 1.12A 4n48A-4ir8A:
undetectable		 4n48A-4ir8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6o METALLOPHOSPHOESTERA
SE

(Ruminiclostridium
thermocellum) 		PF00149
(Metallophos) 		5 GLY A 274
LEU A 272
ASN A 273
THR A 286
LEU A 283
 None
 1.09A 4n48A-4j6oA:
undetectable		 4n48A-4j6oA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A3851
GLY A3838
THR A3874
LEU A3871
LEU A3929
 None
 1.09A 4n48A-4kc5A:
undetectable		 4n48A-4kc5A:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		12 CYH A 277
GLY A 279
PRO A 280
GLY A 281
PHE A 283
THR A 301
LEU A 302
ASN A 306
ILE A 336
THR A 337
GLY A 365
LEU A 383
 SAM  A 601 (-3.7A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.5A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
None
SAM  A 601 (-4.1A)
SAM  A 601 ( 3.9A)
SAM  A 601 ( 4.0A)
SAM  A 601 (-4.6A)
 0.23A 4n48A-4n49A:
68.2		 4n48A-4n49A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		5 PRO A 280
LEU A 302
THR A 337
GLY A 366
LEU A 383
 SAM  A 601 (-3.6A)
SAM  A 601 (-4.1A)
SAM  A 601 ( 3.9A)
SAM  A 601 (-4.6A)
SAM  A 601 (-4.6A)
 1.10A 4n48A-4n49A:
68.2		 4n48A-4n49A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Bacillus
subtilis) 		no annotation 5 GLY A 109
PRO A 110
GLY A  66
ASN A 108
ILE A 102
 None
 1.24A 4n48A-4p8iA:
undetectable		 4n48A-4p8iA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 GLY A  61
GLY A  58
ILE A 319
GLY A 266
LEU A 271
 None
 0.90A 4n48A-4pvvA:
3.3		 4n48A-4pvvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r72 ABC-TYPE FE3+
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Actinobacillus
pleuropneumoniae) 		PF13343
(SBP_bac_6) 		5 GLY A 225
PHE A 158
LEU A 288
GLY A 108
LEU A 204
 None
None
GOL  A 404 (-3.9A)
None
None
 0.88A 4n48A-4r72A:
undetectable		 4n48A-4r72A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 5 GLY B 268
GLY B 210
THR B 305
ASN B 289
GLY B 286
 None
None
None
CA  B 701 ( 2.8A)
None
 1.07A 4n48A-4tqoB:
undetectable		 4n48A-4tqoB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4who PROTOCATECHUATE
3,4-DIOXYGENASE
ALPHA CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C) 		5 GLY A 112
GLY A  77
ILE A  49
THR A 181
GLY A  46
 None
 1.02A 4n48A-4whoA:
undetectable		 4n48A-4whoA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 GLY A 320
GLY A 269
ILE A 316
GLY A 325
LEU A 177
 None
 0.83A 4n48A-4y9lA:
undetectable		 4n48A-4y9lA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z38 MLNA

(Bacillus
velezensis) 		no annotation 5 GLY A 371
GLY A 351
ASN A 400
GLY A 368
LEU A 367
 None
None
FMN  A 900 ( 3.3A)
None
None
 1.05A 4n48A-4z38A:
undetectable		 4n48A-4z38A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT BETA
UREASE SUBUNIT ALPHA

(Yersinia
enterocolitica;
Yersinia
enterocolitica) 		PF00699
(Urease_beta)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 GLY B 119
PHE B 118
THR C  73
GLY C  56
LEU C  51
 None
 1.21A 4n48A-4z42B:
undetectable		 4n48A-4z42B:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 GLY A 286
PRO A 287
LEU A 258
THR A 246
GLY A 266
 None
 1.21A 4n48A-4ztxA:
undetectable		 4n48A-4ztxA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2z EXFOLIATIVE TOXIN D2

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 GLY A  83
GLY A  71
THR A  93
ILE A 148
LEU A 270
 None
 1.19A 4n48A-5c2zA:
undetectable		 4n48A-5c2zA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dku PREX DNA POLYMERASE

(Plasmodium
falciparum) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		5 GLY A 549
GLY A 376
PHE A 374
THR A 526
LEU A 527
 None
 1.29A 4n48A-5dkuA:
undetectable		 4n48A-5dkuA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgw EXTRACELLULAR
STREPTODORNASE D

(Streptococcus
pyogenes) 		PF01223
(Endonuclease_NS) 		5 GLY A 103
GLY A 101
ILE A 204
GLY A 106
LEU A 189
 None
 1.15A 4n48A-5fgwA:
undetectable		 4n48A-5fgwA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 CYH A  87
GLY A 106
ASN A 107
ILE A  79
GLY A1066
 None
 1.25A 4n48A-5fqdA:
undetectable		 4n48A-5fqdA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6c URIC ACID-XANTHINE
PERMEASE

(Aspergillus
nidulans) 		PF00860
(Xan_ur_permease) 		5 GLY A 340
PRO A 341
PHE A 165
THR A 195
GLY A 190
 None
 1.29A 4n48A-5i6cA:
undetectable		 4n48A-5i6cA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifz RIBOSE 5-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		PF02502
(LacAB_rpiB) 		5 GLY A  81
GLY A  83
THR A 118
ILE A  75
LEU A  31
 None
 1.30A 4n48A-5ifzA:
undetectable		 4n48A-5ifzA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE

(Bacillus
anthracis) 		PF04127
(DFP) 		5 GLY A 195
PRO A 196
GLY A 235
ILE A 271
GLY A 216
 None
 1.03A 4n48A-5intA:
3.3		 4n48A-5intA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz3 PREDICTED PROTEIN

(Physcomitrella
patens) 		PF00316
(FBPase) 		5 GLY B 221
PRO B 222
ILE B 111
GLY B 193
LEU B 180
 None
 0.99A 4n48A-5iz3B:
undetectable		 4n48A-5iz3B:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp5 GALECTIN-5

(Rattus
norvegicus) 		PF00337
(Gal-bind_lectin) 		5 PRO A 127
GLY A  24
LEU A 123
ILE A  54
GLY A  51
 None
 0.93A 4n48A-5jp5A:
undetectable		 4n48A-5jp5A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA

(Mus musculus) 		PF01532
(Glyco_hydro_47) 		5 GLY A 481
GLY A 503
THR A 553
ILE A 551
THR A 612
 None
 1.25A 4n48A-5kkbA:
undetectable		 4n48A-5kkbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kss 5'-NUCLEOTIDASE SURE

(Xylella
fastidiosa) 		PF01975
(SurE) 		5 GLY A 105
THR A  69
THR A  77
GLY A 113
LEU A 116
 CL  A 504 ( 4.9A)
None
None
None
None
 1.16A 4n48A-5kssA:
undetectable		 4n48A-5kssA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		5 GLY A  90
GLY A  87
PHE A 118
LEU A 220
ILE A  82
 None
FAD  A 700 (-3.5A)
None
None
None
 0.82A 4n48A-5mq6A:
undetectable		 4n48A-5mq6A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu5 UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		no annotation 5 GLY A 457
GLY A 461
ASN A 458
THR A 472
GLY A 417
 None
CL  A 703 ( 3.7A)
None
None
None
 1.16A 4n48A-5mu5A:
undetectable		 4n48A-5mu5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 5 GLY A 438
GLY A 421
ASN A 437
ILE A 442
THR A 448
 None
None
NAG  A1129 (-1.9A)
None
None
 1.13A 4n48A-5nbsA:
3.0		 4n48A-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE

(Fusobacterium
nucleatum) 		PF00480
(ROK) 		5 GLY A 276
GLY A 279
ILE A  13
THR A  32
GLY A  64
 None
 1.06A 4n48A-5nckA:
undetectable		 4n48A-5nckA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfh SALT STRESS-INDUCED
PROTEIN

(Oryza sativa) 		no annotation 5 GLY A 140
GLY A   7
ILE A  75
GLY A 127
LEU A  26
 None
 0.98A 4n48A-5xfhA:
undetectable		 4n48A-5xfhA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		5 CYH A 294
GLY A 292
GLY A 238
GLY A 308
LEU A 315
 None
 1.24A 4n48A-5xgsA:
undetectable		 4n48A-5xgsA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f74 ALCOHOL OXIDASE

(Thermothelomyces
thermophila) 		no annotation 5 GLY A 247
GLY A 229
THR A 250
GLY A 244
LEU A 489
 None
FAD  A 601 ( 4.0A)
None
None
None
 1.03A 4n48A-6f74A:
undetectable		 4n48A-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gkv COCLAURINE
N-METHYLTRANSFERASE

(Coptis japonica) 		no annotation 5 GLY A 139
GLY A 141
THR A 160
ILE A 188
THR A 189
 SAH  A 501 (-3.1A)
None
SAH  A 501 ( 4.8A)
SAH  A 501 (-3.9A)
None
 0.78A 4n48A-6gkvA:
7.4		 4n48A-6gkvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ALA C  10
GLY C  14
ASP C 396
ASP C  19
 None
 0.84A 4n48A-1a5lC:
undetectable		 4n48A-1a5lC:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bk6 KARYOPHERIN ALPHA

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 ALA A 480
GLY A 481
ASP A 441
ASP A 435
 None
 1.00A 4n48A-1bk6A:
undetectable		 4n48A-1bk6A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		4 ALA A  35
GLY A  64
ASP A  99
ASP A 124
 SAM  A 301 (-3.3A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
 0.30A 4n48A-1eizA:
18.3		 4n48A-1eizA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsj FUSION PROTEIN
CONSISTING OF
STAPHYLOCOCCUS
ACCESSORY REGULATOR
PROTEIN R AND
MALTOSE BINDING
PROTEIN

(Escherichia
coli;
Staphylococcus
aureus) 		PF01547
(SBP_bac_1) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
GLC  A 672 (-3.0A)
 0.98A 4n48A-1hsjA:
undetectable		 4n48A-1hsjA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ASN A 157
ALA A 155
GLY A 151
ASP A 249
 None
 0.99A 4n48A-1iyxA:
undetectable		 4n48A-1iyxA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg1 PROTEIN (HTLV-1 GP21
ECTODOMAIN/MALTOSE-B
INDING PROTEIN
CHIMERA)

(Primate
T-lymphotropic
virus 1) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MAL  A 456 (-3.4A)
 0.98A 4n48A-1mg1A:
undetectable		 4n48A-1mg1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		4 ALA A 208
GLY A 206
ASP A 254
ASP A 170
 None
 0.96A 4n48A-1r6vA:
1.9		 4n48A-1r6vA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Escherichia
coli;
Drosophila
melanogaster) 		no annotation 4 ASN P 266
ALA P  50
GLY P  55
ASP P  13
 None
None
None
MAL  P 727 (-3.0A)
 0.97A 4n48A-1r6zP:
undetectable		 4n48A-1r6zP:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		4 ASN A 897
ALA A 911
GLY A 909
ASP A1151
 CA  A2005 (-3.3A)
None
CA  A2003 ( 4.8A)
None
 0.97A 4n48A-1ux6A:
undetectable		 4n48A-1ux6A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		4 ALA A 100
GLY A 105
ASP A  78
ASP A 102
 None
 0.90A 4n48A-1wx4A:
undetectable		 4n48A-1wx4A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x55 ASPARAGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ALA A 346
GLY A 324
ASP A 307
ASP A 348
 None
None
None
MG  A2001 ( 4.0A)
 0.90A 4n48A-1x55A:
undetectable		 4n48A-1x55A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4c MALTOSE BINDING
PROTEIN FUSED WITH
DESIGNED HELICAL
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
GLC  A 371 (-3.2A)
 0.95A 4n48A-1y4cA:
undetectable		 4n48A-1y4cA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		4 ASN A 672
GLY A 675
ASP A 313
ASP A 136
 None
 0.81A 4n48A-1z26A:
undetectable		 4n48A-1z26A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE

(Bacillus sp.
NG-27) 		PF00331
(Glyco_hydro_10) 		4 ASN A 328
ALA A 272
GLY A 332
ASP A 334
 None
 1.01A 4n48A-2f8qA:
undetectable		 4n48A-2f8qA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzm GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		4 ALA A  39
GLY A 241
ASP A  64
ASP A  37
 None
 0.85A 4n48A-2gzmA:
undetectable		 4n48A-2gzmA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ASN A 159
ALA A 157
GLY A 153
ASP A 251
 None
 0.93A 4n48A-2ptzA:
undetectable		 4n48A-2ptzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9z GLUTATHIONE AMIDE
REDUCTASE

(Marichromatium
gracile) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASN A  44
ALA A  37
GLY A  39
ASP A  99
 None
 0.86A 4n48A-2r9zA:
1.9		 4n48A-2r9zA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwf ALKALINE ACTIVE
ENDOXYLANASE

(Bacillus
halodurans) 		PF00331
(Glyco_hydro_10) 		4 ASN A 334
ALA A 278
GLY A 338
ASP A 340
 None
 0.97A 4n48A-2uwfA:
undetectable		 4n48A-2uwfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MTT  A1463 (-2.9A)
 0.96A 4n48A-2vgqA:
undetectable		 4n48A-2vgqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine leukemia
virus) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		4 ASN A 293
ALA A  77
GLY A  82
ASP A  40
 EDO  A1494 ( 4.1A)
None
EDO  A1494 (-4.4A)
MAL  A1488 (-3.0A)
 0.95A 4n48A-2xz3A:
undetectable		 4n48A-2xz3A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csg MALTOSE-BINDING
PROTEIN MONOBODY YS1
FUSION

(Escherichia
coli) 		PF00041
(fn3)
PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
 0.95A 4n48A-3csgA:
undetectable		 4n48A-3csgA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Escherichia
coli;
Arabidopsis
thaliana) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
GLC  A 672 (-3.1A)
 0.98A 4n48A-3dm0A:
undetectable		 4n48A-3dm0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		4 ALA A  22
GLY A  51
ASP A  83
ASP A 111
 SAM  A   1 (-3.3A)
SAM  A   1 (-3.2A)
SAM  A   1 (-3.6A)
SAM  A   1 (-3.7A)
 0.36A 4n48A-3douA:
16.4		 4n48A-3douA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		5 ASN X   9
ALA X  11
GLY X  12
ASP X 226
ASP X 344
 None
 1.22A 4n48A-3dwoX:
undetectable		 4n48A-3dwoX:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		4 ASN A 170
ALA A 172
GLY A 173
ASP A 273
 None
None
SO4  A 520 (-3.7A)
None
 0.98A 4n48A-3ed4A:
undetectable		 4n48A-3ed4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
GLC  A 672 (-3.2A)
 1.01A 4n48A-3f5fA:
undetectable		 4n48A-3f5fA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Escherichia
coli;
Dermatophagoides
pteronyssinus) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
GLC  A 672 (-3.1A)
 0.97A 4n48A-3h4zA:
undetectable		 4n48A-3h4zA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ist GLUTAMATE RACEMASE

(Listeria
monocytogenes) 		PF01177
(Asp_Glu_race) 		4 ALA A  37
GLY A 239
ASP A  62
ASP A  35
 None
 0.76A 4n48A-3istA:
undetectable		 4n48A-3istA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 ASN A  57
ALA A 303
GLY A  53
ASP A 324
 None
 0.99A 4n48A-3iveA:
undetectable		 4n48A-3iveA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Thermococcus
kodakarensis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ALA A 140
GLY A 138
ASP A 255
ASP A 311
 None
 0.95A 4n48A-3kdnA:
undetectable		 4n48A-3kdnA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		4 ALA A 280
GLY A 284
ASP A 669
ASP A 289
 None
 0.91A 4n48A-3la4A:
undetectable		 4n48A-3la4A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Novosphingobium
aromaticivorans) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 ALA A 307
GLY A  20
ASP A 140
ASP A 285
 FAD  A 416 (-3.5A)
FAD  A 416 (-3.3A)
None
FAD  A 416 (-2.9A)
 0.82A 4n48A-3lxdA:
undetectable		 4n48A-3lxdA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp6 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,LINKER,SAGA-
ASSOCIATED FACTOR 29

(Escherichia
coli;
Saccharomyces
cerevisiae;
unidentified) 		PF07039
(DUF1325)
PF13416
(SBP_bac_8) 		4 ASN A1005
ALA A 789
GLY A 794
ASP A 752
 None
None
None
MAL  A 600 (-2.9A)
 0.95A 4n48A-3mp6A:
undetectable		 4n48A-3mp6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n93 MALTOSE BINDING
PROTEIN-CRFR2 ALPHA

(Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 ASN A-103
ALA A-319
GLY A-314
ASP A-356
 None
None
None
MAL  A 111 (-3.1A)
 0.98A 4n48A-3n93A:
undetectable		 4n48A-3n93A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 ASN A -81
ALA A-297
GLY A-292
ASP A-334
 None
None
None
MAL  A5044 (-3.1A)
 1.00A 4n48A-3n94A:
undetectable		 4n48A-3n94A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF08205
(C2-set_2)
PF13416
(SBP_bac_8) 		4 ASN N 267
ALA N  51
GLY N  56
ASP N  14
 None
None
None
MLR  N2001 (-3.0A)
 0.95A 4n48A-3o3uN:
undetectable		 4n48A-3o3uN:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Escherichia
coli;
Arachis
duranensis) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MLR  A 400 (-3.1A)
 0.98A 4n48A-3ob4A:
undetectable		 4n48A-3ob4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 ASN A 515
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MAL  A 700 (-2.8A)
 0.96A 4n48A-3osqA:
undetectable		 4n48A-3osqA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MAL  A 700 (-3.1A)
 0.99A 4n48A-3osrA:
undetectable		 4n48A-3osrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2n 3,6-ANHYDRO-ALPHA-L-
GALACTOSIDASE

(Zobellia
galactanivorans) 		PF04616
(Glyco_hydro_43) 		4 ALA A 337
GLY A 319
ASP A 290
ASP A 339
 None
 1.00A 4n48A-3p2nA:
undetectable		 4n48A-3p2nA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py7 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PAXILLIN
LD1,PROTEIN E6
CHIMERA

(Escherichia
coli;
Homo sapiens;
Deltapapillomavirus
4) 		PF00518
(E6)
PF01547
(SBP_bac_1) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MLR  A 701 (-3.0A)
 0.99A 4n48A-3py7A:
undetectable		 4n48A-3py7A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		4 ALA A 195
GLY A 156
ASP A  94
ASP A 222
 None
 1.00A 4n48A-3ut2A:
undetectable		 4n48A-3ut2A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vd8 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
INTERFERON-INDUCIBLE
PROTEIN AIM2

(Escherichia
coli;
Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MTT  A1205 (-3.1A)
 0.96A 4n48A-3vd8A:
undetectable		 4n48A-3vd8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdn MONOAMINE OXIDASE N

(Aspergillus
niger) 		PF01593
(Amino_oxidase) 		4 ASN A 284
ALA A 289
GLY A 451
ASP A 458
 None
 0.80A 4n48A-3zdnA:
undetectable		 4n48A-3zdnA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		4 ASN A 185
ALA A 188
GLY A 166
ASP A 487
 None
 1.00A 4n48A-4dxbA:
undetectable		 4n48A-4dxbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
 0.95A 4n48A-4dxbA:
undetectable		 4n48A-4dxbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		PF00046
(Homeobox)
PF13416
(SBP_bac_8)
PF16878
(SIX1_SD) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MAL  A 601 (-2.9A)
 0.95A 4n48A-4egcA:
undetectable		 4n48A-4egcA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 ALA A  96
GLY A 131
ASP A 343
ASP A 129
 None
 0.99A 4n48A-4fixA:
undetectable		 4n48A-4fixA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Escherichia
coli;
Candida
albicans) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		4 ASN A-103
ALA A-319
GLY A-314
ASP A-356
 None
None
None
MTT  A 701 (-2.9A)
 0.97A 4n48A-4h1gA:
undetectable		 4n48A-4h1gA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		4 ALA A  79
GLY A 107
ASP A 221
ASP A  81
 None
 0.96A 4n48A-4hwvA:
undetectable		 4n48A-4hwvA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		4 ASN A 213
GLY A 495
ASP A 262
ASP A 189
 None
 0.75A 4n48A-4hwvA:
undetectable		 4n48A-4hwvA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4i 6-PHOSPHOFRUCTOKINAS
E

(Geobacillus
stearothermophilus) 		PF00365
(PFK) 		4 ASN A  17
GLY A  64
ASP A 129
ASP A  12
 None
 0.90A 4n48A-4i4iA:
undetectable		 4n48A-4i4iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MAL  A 501 (-3.0A)
 0.96A 4n48A-4ifpA:
undetectable		 4n48A-4ifpA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MAL  A 501 (-3.1A)
 1.00A 4n48A-4ikmA:
undetectable		 4n48A-4ikmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Escherichia
coli;
Danio rerio) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MTT  A 501 (-3.0A)
 0.94A 4n48A-4irlA:
undetectable		 4n48A-4irlA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
 0.98A 4n48A-4kegA:
undetectable		 4n48A-4kegA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkr RBMA PROTEIN

(Vibrio cholerae) 		no annotation 4 ASN A 192
ALA A 198
ASP A 126
ASP A 255
 None
 0.97A 4n48A-4kkrA:
undetectable		 4n48A-4kkrA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 ASN A 402
ALA A 243
GLY A 242
ASP A 196
 None
 0.89A 4n48A-4lglA:
2.2		 4n48A-4lglA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 ASN A 269
ALA A  53
GLY A  58
ASP A  16
 None
 0.98A 4n48A-4logA:
undetectable		 4n48A-4logA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		4 ALA A  58
GLY A 131
ASP A 291
ASP A 104
 PO4  A 401 (-3.2A)
None
None
PO4  A 401 (-3.1A)
 1.00A 4n48A-4lvqA:
undetectable		 4n48A-4lvqA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9x CELL DEATH PROTEIN 4

(Caenorhabditis
elegans) 		PF00619
(CARD)
PF00931
(NB-ARC) 		4 ASN A 329
ALA A 331
GLY A 162
ASP A 138
 None
ATP  A 602 (-3.7A)
ATP  A 602 (-3.6A)
None
 0.99A 4n48A-4m9xA:
undetectable		 4n48A-4m9xA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		4 ASN A  56
ALA A  54
GLY A 103
ASP A 240
 None
 0.94A 4n48A-4madA:
undetectable		 4n48A-4madA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF00007
(Cys_knot)
PF13416
(SBP_bac_8) 		4 ASN A 269
ALA A  53
GLY A  58
ASP A  16
 None
None
None
MAL  A1201 (-3.0A)
 0.96A 4n48A-4my2A:
undetectable		 4n48A-4my2A:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		5 ASN A 234
ALA A 236
GLY A 282
ASP A 335
ASP A 364
 SAM  A 601 (-3.3A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
 0.19A 4n48A-4n49A:
68.2		 4n48A-4n49A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe2 MALTOSE ABC
TRANSPORTER
PERIPLASMIC
PROTEIN,PREPILIN-TYP
E N-TERMINAL
CLEAVAGE/METHYLATION
DOMAIN PROTEIN

(Escherichia
coli;
Clostridioides
difficile) 		PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MAL  A 601 (-3.1A)
 0.98A 4n48A-4pe2A:
undetectable		 4n48A-4pe2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA

(Escherichia
coli;
Mus musculus) 		PF13416
(SBP_bac_8)
PF13621
(Cupin_8) 		4 ASN A-104
ALA A-320
GLY A-315
ASP A-357
 None
None
None
GLC  A 901 (-2.9A)
 1.01A 4n48A-4qszA:
undetectable		 4n48A-4qszA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF01648
(ACPS)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MAL  A 601 (-3.1A)
 1.00A 4n48A-4qvhA:
undetectable		 4n48A-4qvhA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1

(Escherichia
coli;
Rattus
norvegicus) 		PF03359
(GKAP)
PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
 0.93A 4n48A-4r0yA:
undetectable		 4n48A-4r0yA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		4 ASN A 269
ALA A  53
GLY A  58
ASP A  16
 None
None
None
MAL  A2201 (-3.0A)
 0.97A 4n48A-4rwfA:
undetectable		 4n48A-4rwfA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		4 ASN A  74
GLY A  54
ASP A 135
ASP A  13
 DDZ  A  53 ( 4.2A)
DDZ  A  53 ( 2.4A)
None
ZN  A1576 (-2.1A)
 1.01A 4n48A-4upiA:
undetectable		 4n48A-4upiA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xai MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TAILLESS
ORTHOLOG

(Escherichia
coli;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 ASN A 269
ALA A  53
GLY A  58
ASP A  16
 None
None
None
MAL  A1401 (-3.2A)
 1.01A 4n48A-4xaiA:
undetectable		 4n48A-4xaiA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaj MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR
RECEPTOR SUBFAMILY 2
GROUP E MEMBER 1

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 ASN A 269
ALA A  53
GLY A  58
ASP A  16
 None
None
None
MAL  A1900 (-3.2A)
 0.95A 4n48A-4xajA:
undetectable		 4n48A-4xajA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT ALPHA

(Yersinia
enterocolitica) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ALA C  10
GLY C  14
ASP C 401
ASP C  19
 None
 1.01A 4n48A-4z42C:
undetectable		 4n48A-4z42C:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE

(Helicobacter
pylori) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 ALA A 366
GLY A 284
ASP A 356
ASP A 364
 None
 0.90A 4n48A-4zi6A:
undetectable		 4n48A-4zi6A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MAL  A 901 (-2.9A)
 0.98A 4n48A-5azaA:
undetectable		 4n48A-5azaA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MALTOSE-BIND
ING PERIPLASMIC
PROTEIN,PILA FUSION
PROTEIN

(Escherichia
coli;
Acinetobacter
nosocomialis) 		PF00114
(Pilin)
PF01547
(SBP_bac_1) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MAL  A1201 (-3.0A)
 0.97A 4n48A-5cfvA:
undetectable		 4n48A-5cfvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASN A 217
ALA A 224
GLY A 226
ASP A  83
 None
 0.89A 4n48A-5fr8A:
undetectable		 4n48A-5fr8A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ALA C   9
GLY C  13
ASP C 399
ASP C  18
 None
 0.94A 4n48A-5fseC:
undetectable		 4n48A-5fseC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Escherichia
coli;
Danio rerio) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MAL  A 501 (-3.1A)
 0.99A 4n48A-5gpqA:
undetectable		 4n48A-5gpqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MTT  A 501 (-3.1A)
 0.97A 4n48A-5h7nA:
undetectable		 4n48A-5h7nA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz7 COMP

(Neisseria
meningitidis) 		PF13416
(SBP_bac_8)
PF16732
(ComP_DUS) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MLR  A 501 (-2.2A)
 0.97A 4n48A-5hz7A:
undetectable		 4n48A-5hz7A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		4 ASN A3934
ALA A3718
GLY A3723
ASP A3681
 None
None
None
MAL  A4201 (-2.6A)
 0.96A 4n48A-5ii5A:
undetectable		 4n48A-5ii5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		4 ASN A4236
ALA A4020
GLY A4025
ASP A3983
 None
None
None
MAL  A4501 (-3.0A)
 1.01A 4n48A-5iicA:
undetectable		 4n48A-5iicA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 4 ASN B 653
ALA B 649
GLY B 329
ASP B 758
 None
 0.95A 4n48A-5iz5B:
undetectable		 4n48A-5iz5B:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE

(Escherichia
coli;
Homo sapiens) 		no annotation 4 ASN C 267
ALA C  51
GLY C  56
ASP C  14
 None
None
None
MTT  C1203 (-3.2A)
 0.99A 4n48A-5jj4C:
undetectable		 4n48A-5jj4C:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8) 		PF11991
(Trp_DMAT) 		4 ASN A 183
ALA A 185
GLY A 160
ASP A 317
 None
 1.00A 4n48A-5jxmA:
undetectable		 4n48A-5jxmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 ASN A1267
ALA A  51
GLY A  56
ASP A  14
 None
 0.97A 4n48A-5k94A:
undetectable		 4n48A-5k94A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3

(Escherichia
coli;
Mus musculus) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MAL  A 501 (-2.5A)
 0.99A 4n48A-5osqA:
undetectable		 4n48A-5osqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio rerio) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
GLC  A1412 ( 3.0A)
 0.98A 4n48A-5t03A:
undetectable		 4n48A-5t03A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		4 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MAL  A1501 (-3.2A)
 0.96A 4n48A-5tj2A:
undetectable		 4n48A-5tj2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Brucella canis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ASN A 243
ALA A 245
GLY A 252
ASP A 429
 None
 0.97A 4n48A-5u2aA:
1.7		 4n48A-5u2aA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		PF16679
(CDT1_C) 		4 ALA 8 237
GLY 8 242
ASP 8 216
ASP 8  41
 None
 0.93A 4n48A-5udb8:
undetectable		 4n48A-5udb8:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq6 MBP TAGGED HMNDA-PYD

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MAL  A 501 (-2.9A)
 0.93A 4n48A-5wq6A:
undetectable		 4n48A-5wq6A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE

(Escherichia
coli;
Serratia
marcescens) 		no annotation 4 ASN A 269
ALA A  53
GLY A  58
ASP A  16
 None
None
None
SO4  A 601 ( 4.0A)
 1.00A 4n48A-5wvmA:
undetectable		 4n48A-5wvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xr2 PROTEIN/NUCLEIC ACID
DEGLYCASE HCHA

(Staphylococcus
aureus) 		no annotation 4 ASN A  77
ALA A  60
GLY A  76
ASP A 218
 None
 0.89A 4n48A-5xr2A:
2.7		 4n48A-5xr2A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 4 ALA A 719
GLY A 722
ASP A 737
ASP A 727
 None
 1.00A 4n48A-5yp3A:
1.6		 4n48A-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage JBD30) 		no annotation 4 ASN A 347
ALA A 131
GLY A 136
ASP A  94
 None
None
None
MTT  A 501 ( 3.0A)
 1.00A 4n48A-6anvA:
undetectable		 4n48A-6anvA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dm8 -

(-) 		no annotation 4 ASN A  52
ALA A-164
GLY A-159
ASP A-201
 None
None
None
MAL  A 402 (-3.1A)
 0.98A 4n48A-6dm8A:
undetectable		 4n48A-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 ASN A  82
ALA A 111
GLY A  87
ASP A 184
 None
 0.81A 4n48A-6evgA:
undetectable		 4n48A-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhf -

(-) 		no annotation 4 ASN A 336
ALA A 280
GLY A 340
ASP A 342
 None
 0.94A 4n48A-6fhfA:
undetectable		 4n48A-6fhfA:
undetectable