SIMILAR PATTERNS OF AMINO ACIDS FOR 4N09_D_ADND401_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcn DELTA 2 CRYSTALLIN

(Anas
platyrhynchos)
PF00206
(Lyase_1)
PF14698
(ASL_C2)
4 LEU A 182
SER A 177
LEU A 457
LEU A 141
None
1.29A 4n09D-1dcnA:
undetectable
4n09D-1dcnA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.)
no annotation 4 CYH B 925
LEU B 997
SER B 517
LEU B 987
None
1.33A 4n09D-1ej6B:
undetectable
4n09D-1ej6B:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2r INHIBITOR OF
CASPASE-ACTIVATED
DNASE


(Mus musculus)
PF02017
(CIDE-N)
4 LEU I  42
SER I  44
LEU I  49
LEU I  61
None
1.30A 4n09D-1f2rI:
undetectable
4n09D-1f2rI:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuu YEAST INITIATION
FACTOR 4A


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
4 CYH A 123
LEU A  93
LEU A 189
LEU A  95
None
1.04A 4n09D-1fuuA:
4.2
4n09D-1fuuA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqp DOC1/APC10

(Saccharomyces
cerevisiae)
PF03256
(ANAPC10)
4 LEU A 156
SER A 126
LEU A 234
LEU A 247
None
1.26A 4n09D-1gqpA:
undetectable
4n09D-1gqpA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens)
PF00704
(Glyco_hydro_18)
4 LEU A 127
SER A 122
LEU A 162
LEU A  94
None
1.22A 4n09D-1hkkA:
3.6
4n09D-1hkkA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i0a DELTA CRYSTALLIN I

(Meleagris
gallopavo)
PF00206
(Lyase_1)
PF14698
(ASL_C2)
4 LEU A 180
SER A 175
LEU A 455
LEU A 139
None
1.33A 4n09D-1i0aA:
undetectable
4n09D-1i0aA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis)
PF12468
(TTSSLRR)
4 LEU A1109
SER A1115
LEU A1093
LEU A1106
None
1.19A 4n09D-1jl5A:
undetectable
4n09D-1jl5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis)
PF12468
(TTSSLRR)
4 LEU A1136
SER A1139
LEU A1117
LEU A1126
None
1.25A 4n09D-1jl5A:
undetectable
4n09D-1jl5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis)
PF12468
(TTSSLRR)
4 LEU A1213
SER A1219
LEU A1197
LEU A1210
None
1.27A 4n09D-1jl5A:
undetectable
4n09D-1jl5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1b B-CELL LYMPHOMA
3-ENCODED PROTEIN


(Homo sapiens)
PF00023
(Ank)
PF12796
(Ank_2)
4 LEU A 305
SER A 307
LEU A 316
LEU A 350
None
1.18A 4n09D-1k1bA:
undetectable
4n09D-1k1bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF


(Saccharomyces
cerevisiae)
PF00117
(GATase)
PF00977
(His_biosynth)
4 LEU B 468
SER B 402
LEU B 454
LEU B 484
None
1.33A 4n09D-1ox4B:
2.3
4n09D-1ox4B:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdz ENOLASE

(Homarus
gammarus)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 LEU A 144
SER A 176
LEU A 412
LEU A 418
None
1.24A 4n09D-1pdzA:
undetectable
4n09D-1pdzA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qva INITIATION FACTOR 4A

(Saccharomyces
cerevisiae)
PF00270
(DEAD)
4 CYH A 123
LEU A  93
LEU A 189
LEU A  95
None
1.13A 4n09D-1qvaA:
4.0
4n09D-1qvaA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgj CITRATE LYASE, BETA
SUBUNIT


(Deinococcus
radiodurans)
PF03328
(HpcH_HpaI)
4 LEU A 190
SER A  10
LEU A   7
LEU A 125
None
0.95A 4n09D-1sgjA:
2.7
4n09D-1sgjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smt TRANSCRIPTIONAL
REPRESSOR SMTB


(Synechococcus
elongatus)
PF01022
(HTH_5)
4 LEU A  88
SER A  82
LEU A  51
LEU A  43
None
1.32A 4n09D-1smtA:
undetectable
4n09D-1smtA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens)
PF00704
(Glyco_hydro_18)
4 LEU A 127
SER A 122
LEU A 162
LEU A  94
None
1.23A 4n09D-1wb0A:
2.4
4n09D-1wb0A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A


(Homo sapiens)
PF00233
(PDEase_I)
4 LEU A 198
SER A 172
LEU A 177
LEU A 194
None
1.17A 4n09D-1zklA:
undetectable
4n09D-1zklA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7h HEMOGLOBIN ALPHA
CHAIN


(Cerdocyon thous)
PF00042
(Globin)
4 LEU A  76
SER A 133
LEU A  66
LEU A   2
None
HEM  A 200 ( 4.8A)
HEM  A 200 ( 4.6A)
None
0.91A 4n09D-2b7hA:
undetectable
4n09D-2b7hA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR


(Homo sapiens)
PF13516
(LRR_6)
4 CYH A 304
LEU A 342
LEU A 374
LEU A 317
None
1.24A 4n09D-2bexA:
undetectable
4n09D-2bexA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR


(Sus scrofa)
PF13516
(LRR_6)
4 CYH A 300
LEU A 338
LEU A 370
LEU A 313
None
1.21A 4n09D-2bnhA:
undetectable
4n09D-2bnhA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum)
PF13378
(MR_MLE_C)
4 LEU A 289
SER A 315
LEU A 306
LEU A 277
None
1.30A 4n09D-2dw6A:
undetectable
4n09D-2dw6A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eig LECTIN

(Lotus
tetragonolobus)
PF00139
(Lectin_legB)
4 LEU A 192
SER A 167
LEU A 227
LEU A  86
None
1.25A 4n09D-2eigA:
undetectable
4n09D-2eigA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4r MOLYBDOPTERIN
BIOSYNTHESIS MOG
PROTEIN


(Mycobacterium
tuberculosis)
PF00994
(MoCF_biosynth)
4 CYH A  24
LEU A 128
SER A 131
LEU A 139
None
1.32A 4n09D-2g4rA:
undetectable
4n09D-2g4rA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hes YDR267CP

(Saccharomyces
cerevisiae)
PF00400
(WD40)
4 LEU X  27
SER X  40
LEU X  10
LEU X 304
None
1.33A 4n09D-2hesX:
undetectable
4n09D-2hesX:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN


(Thermoplasma
acidophilum)
PF01019
(G_glu_transpept)
4 LEU A 409
SER A 411
LEU A 439
LEU A 425
None
1.31A 4n09D-2i3oA:
undetectable
4n09D-2i3oA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilx 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE


(Rattus
norvegicus)
PF05881
(CNPase)
4 LEU A  70
SER A  18
LEU A 104
LEU A 153
None
1.29A 4n09D-2ilxA:
undetectable
4n09D-2ilxA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN


(Homo sapiens)
PF02545
(Maf)
4 CYH A 205
LEU A  33
LEU A  17
LEU A  10
None
1.16A 4n09D-2p5xA:
undetectable
4n09D-2p5xA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyf T-CELL RECEPTOR,
BETA CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 LEU B 108
SER B 106
LEU B  74
LEU B  11
None
1.25A 4n09D-2pyfB:
undetectable
4n09D-2pyfB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rt5 MSX2-INTERACTING
PROTEIN


(Homo sapiens)
PF07744
(SPOC)
4 LEU A3642
SER A3637
LEU A3647
LEU A3575
None
1.25A 4n09D-2rt5A:
undetectable
4n09D-2rt5A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE


(Dictyostelium
discoideum)
PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C)
4 LEU A 143
SER A 191
LEU A 146
LEU A 101
None
1.33A 4n09D-2uuuA:
undetectable
4n09D-2uuuA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wui TRANSCRIPTIONAL
REGULATOR


(Pseudomonas
aeruginosa)
PF00440
(TetR_N)
PF08361
(TetR_C_2)
4 LEU A 196
SER A 198
LEU A 166
LEU A  85
None
1.33A 4n09D-2wuiA:
undetectable
4n09D-2wuiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxs PROTEIN MXIG

(Shigella
flexneri)
PF09480
(PrgH)
4 CYH A  72
LEU A 100
SER A  86
LEU A  23
None
1.22A 4n09D-2xxsA:
undetectable
4n09D-2xxsA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf3 HYPOTHETICAL PROTEIN
VIOE


(Chromobacterium
violaceum)
no annotation 4 CYH A  35
SER A  15
LEU A 158
LEU A 110
None
1.23A 4n09D-2zf3A:
undetectable
4n09D-2zf3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4b ALGK

(Pseudomonas
fluorescens)
no annotation 4 LEU A 223
SER A 218
LEU A 240
LEU A 199
None
1.21A 4n09D-3e4bA:
undetectable
4n09D-3e4bA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efb PROBABLE SOR-OPERON
REGULATOR


(Shigella
flexneri)
PF04198
(Sugar-bind)
4 LEU A 263
SER A 258
LEU A  15
LEU A 253
None
1.22A 4n09D-3efbA:
3.8
4n09D-3efbA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evz METHYLTRANSFERASE

(Pyrococcus
furiosus)
PF05175
(MTS)
4 LEU A 202
SER A 239
LEU A 211
LEU A 187
None
1.25A 4n09D-3evzA:
4.8
4n09D-3evzA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7k 3-METHYLITACONATE
ISOMERASE


(Eubacterium
barkeri)
PF04303
(PrpF)
4 LEU A  63
SER A  61
LEU A  39
LEU A  22
None
1.23A 4n09D-3g7kA:
undetectable
4n09D-3g7kA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdj PROBABLE ORNITHINE
CYCLODEAMINASE


(Bordetella
pertussis)
PF02423
(OCD_Mu_crystall)
4 CYH A 165
LEU A 143
LEU A 147
LEU A 137
None
1.30A 4n09D-3hdjA:
4.6
4n09D-3hdjA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Candida
albicans)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
4 LEU A 102
SER A  96
LEU A   9
LEU A  76
None
1.31A 4n09D-3hskA:
3.8
4n09D-3hskA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijf CYTIDINE DEAMINASE

(Mycobacterium
tuberculosis)
PF00383
(dCMP_cyt_deam_1)
4 CYH X  59
LEU X  96
LEU X 119
LEU X  76
None
1.33A 4n09D-3ijfX:
undetectable
4n09D-3ijfX:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 U2 SMALL NUCLEAR
RIBONUCLEOPROTEIN A'


(Schizosaccharomyces
pombe)
PF01423
(LSM)
4 LEU j  92
SER j 118
LEU j  69
LEU j  56
None
1.05A 4n09D-3jb9j:
undetectable
4n09D-3jb9j:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE


(Streptococcus
pneumoniae)
PF05343
(Peptidase_M42)
4 LEU A 207
SER A 209
LEU A  62
LEU A 192
None
1.28A 4n09D-3kl9A:
2.4
4n09D-3kl9A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfk MARR LIKE PROTEIN,
TVG0766549


(Thermoplasma
volcanium)
no annotation 4 LEU A  89
SER A  91
LEU A  77
LEU A  39
None
1.16A 4n09D-3lfkA:
undetectable
4n09D-3lfkA:
17.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE


(Anopheles
gambiae)
PF00294
(PfkB)
4 LEU A  16
SER A  65
LEU A 133
LEU A 137
B4P  A 349 (-4.7A)
CL  A 351 ( 4.6A)
B4P  A 349 (-4.5A)
None
0.47A 4n09D-3looA:
47.9
4n09D-3looA:
36.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC


(Escherichia
coli)
no annotation 4 LEU A 307
SER A 311
LEU A 231
LEU A 326
None
1.26A 4n09D-3ly9A:
undetectable
4n09D-3ly9A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn8 LP15968P

(Drosophila
melanogaster)
PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg)
4 CYH A 299
SER A 213
LEU A 332
LEU A 377
None
1.27A 4n09D-3mn8A:
2.4
4n09D-3mn8A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn8 LP15968P

(Drosophila
melanogaster)
PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg)
4 LEU A 251
SER A 213
LEU A 332
LEU A 377
None
1.13A 4n09D-3mn8A:
2.4
4n09D-3mn8A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwn KINESIN-LIKE PROTEIN
KIF9


(Homo sapiens)
PF00225
(Kinesin)
4 CYH A 295
LEU A 275
SER A 271
LEU A 301
None
1.14A 4n09D-3nwnA:
undetectable
4n09D-3nwnA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3otx ADENOSINE KINASE,
PUTATIVE


(Trypanosoma
brucei)
PF00294
(PfkB)
5 CYH A  12
LEU A  15
SER A  64
LEU A 134
LEU A 138
AP5  A 346 (-3.6A)
AP5  A 346 (-4.4A)
NA  A 347 (-4.8A)
AP5  A 346 ( 4.4A)
None
0.26A 4n09D-3otxA:
58.3
4n09D-3otxA:
99.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s30 HYPOTHETICAL
GLYCOSIDE HYDROLASE


(Bacteroides
vulgatus)
PF13201
(PCMD)
4 LEU A 150
SER A 163
LEU A 160
LEU A 195
None
1.25A 4n09D-3s30A:
undetectable
4n09D-3s30A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc)
4 LEU A1015
SER A1060
LEU A1022
LEU A1156
None
1.19A 4n09D-3s5kA:
undetectable
4n09D-3s5kA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsr RIBONUCLEASE
INHIBITOR


(Mus musculus)
PF13516
(LRR_6)
4 CYH E 300
LEU E 338
LEU E 370
LEU E 313
None
1.19A 4n09D-3tsrE:
undetectable
4n09D-3tsrE:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3c SFN68 FAB

(Oryctolagus
cuniculus)
PF07654
(C1-set)
PF07686
(V-set)
4 LEU L   2
SER L  28
LEU L  32
LEU L   4
None
1.12A 4n09D-4d3cL:
undetectable
4n09D-4d3cL:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewj ENOLASE 2

(Streptococcus
suis)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 LEU A 142
SER A 174
LEU A 412
LEU A 418
None
1.27A 4n09D-4ewjA:
undetectable
4n09D-4ewjA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Zea mays)
PF00145
(DNA_methylase)
PF00385
(Chromo)
PF01426
(BAH)
4 CYH A 512
SER A 354
LEU A 359
LEU A 865
None
0.86A 4n09D-4ft2A:
5.6
4n09D-4ft2A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k37 ANAEROBIC
SULFATASE-MATURATING
ENZYME


(Clostridium
perfringens)
PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12)
4 LEU A 112
SER A 107
LEU A 152
LEU A  97
None
1.04A 4n09D-4k37A:
2.5
4n09D-4k37A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpp PUTATIVE
UNCHARACTERIZED
PROTEIN


(Archaeoglobus
fulgidus)
PF01699
(Na_Ca_ex)
4 LEU A 145
SER A 280
LEU A 140
LEU A 331
None
1.29A 4n09D-4kppA:
undetectable
4n09D-4kppA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK


(Escherichia
coli)
PF02733
(Dak1)
4 CYH A 304
LEU A 272
LEU A 333
LEU A 242
None
1.10A 4n09D-4lryA:
2.8
4n09D-4lryA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN


(Legionella
pneumophila)
no annotation 4 LEU A 438
SER A 440
LEU A 464
LEU A 482
None
1.31A 4n09D-4m0mA:
4.9
4n09D-4m0mA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdr AP-4 COMPLEX SUBUNIT
MU-1


(Homo sapiens)
PF00928
(Adap_comp_sub)
4 LEU A 315
SER A 301
LEU A 377
LEU A 334
None
1.11A 4n09D-4mdrA:
undetectable
4n09D-4mdrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhp GLUTAMINYL CYCLASE,
PUTATIVE


(Ixodes
scapularis)
PF04389
(Peptidase_M28)
4 LEU A 163
SER A 158
LEU A  88
LEU A 175
None
1.07A 4n09D-4mhpA:
undetectable
4n09D-4mhpA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzk UNCHARACTERIZED
PROTEIN


([Eubacterium]
siraeum)
PF14286
(DHHW)
4 CYH A 209
LEU A 314
SER A 332
LEU A 361
None
1.27A 4n09D-4nzkA:
2.5
4n09D-4nzkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1


(Bos taurus)
PF13516
(LRR_6)
4 CYH B 300
LEU B 338
LEU B 370
LEU B 313
None
1.26A 4n09D-4peqB:
undetectable
4n09D-4peqB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1


(Bos taurus)
PF13516
(LRR_6)
4 CYH B 324
LEU B 343
LEU B 313
LEU B 356
None
1.26A 4n09D-4peqB:
undetectable
4n09D-4peqB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1


(Bos taurus)
PF13516
(LRR_6)
4 CYH B 357
LEU B 395
LEU B 427
LEU B 370
None
1.26A 4n09D-4peqB:
undetectable
4n09D-4peqB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR


(Gallus gallus)
PF13516
(LRR_6)
4 CYH A 300
LEU A 338
LEU A 370
LEU A 313
None
1.30A 4n09D-4perA:
undetectable
4n09D-4perA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29


(Fusarium
graminearum)
PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C)
4 LEU A 198
SER A 190
LEU A 195
LEU A 206
None
1.04A 4n09D-4pspA:
2.9
4n09D-4pspA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxh PEPTIDE SYNTHETASE

(Streptomyces
sp. Acta 2897)
PF00550
(PP-binding)
4 LEU B  60
SER B  50
LEU B  62
LEU B  74
None
1.07A 4n09D-4pxhB:
undetectable
4n09D-4pxhB:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdg PUTATIVE ADHESIN

(Bacteroides
thetaiotaomicron)
PF08842
(Mfa2)
4 LEU A  97
SER A  44
LEU A 161
LEU A  68
None
1.22A 4n09D-4qdgA:
undetectable
4n09D-4qdgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdn FLAGELLAR PROTEIN
FLGJ [PEPTIDOGLYCAN
HYDROLASE]


(Thermotoga
maritima)
PF01832
(Glucosaminidase)
4 LEU A  27
SER A  12
LEU A  46
LEU A  89
None
1.05A 4n09D-4qdnA:
undetectable
4n09D-4qdnA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfv ANK-N5C-281

(synthetic
construct)
PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
4 LEU A 174
SER A 176
LEU A 185
LEU A 222
None
1.24A 4n09D-4qfvA:
undetectable
4n09D-4qfvA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlv ADP-RIBOSYLATING
TOXIN CARDS


(Mycoplasma
pneumoniae)
PF02917
(Pertussis_S1)
4 LEU A  38
SER A 225
LEU A 123
LEU A 260
None
1.27A 4n09D-4tlvA:
undetectable
4n09D-4tlvA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
4 LEU A 656
SER A 669
LEU A 662
LEU A 618
None
1.09A 4n09D-4w8jA:
undetectable
4n09D-4w8jA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yac C
ALPHA-DEHYDROGENASE


(Sphingobium sp.
SYK-6)
PF00106
(adh_short)
4 LEU A 185
SER A 144
LEU A 250
LEU A 234
None
0.85A 4n09D-4yacA:
7.8
4n09D-4yacA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z17 ENOLASE

(Chloroflexus
aurantiacus)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 LEU A 143
SER A 175
LEU A 406
LEU A 412
None
1.22A 4n09D-4z17A:
undetectable
4n09D-4z17A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1


(Daucus carota)
PF00560
(LRR_1)
PF13855
(LRR_8)
4 LEU A 451
SER A 446
LEU A 469
LEU A 430
None
1.24A 4n09D-4z61A:
undetectable
4n09D-4z61A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7


(Saccharomyces
cerevisiae)
PF00009
(GTP_EFTU)
4 LEU A 687
SER A 697
LEU A 704
LEU A 674
LEU  A 687 ( 0.6A)
SER  A 697 ( 0.0A)
LEU  A 704 ( 0.6A)
LEU  A 674 ( 0.6A)
1.10A 4n09D-4zkeA:
3.7
4n09D-4zkeA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoq INTRACELLULAR SERINE
PROTEASE


(Bacillus
licheniformis)
PF00082
(Peptidase_S8)
4 LEU I 345
SER I 370
LEU I 377
LEU I 330
None
1.02A 4n09D-4zoqI:
4.9
4n09D-4zoqI:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by7 3-OXOACYL-ACP
SYNTHASE III


(Verrucosispora
maris)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 LEU A 167
SER A -10
LEU A 127
LEU A 111
None
1.13A 4n09D-5by7A:
undetectable
4n09D-5by7A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2


(Homo sapiens)
PF02146
(SIR2)
4 CYH A 148
LEU A 258
LEU A 284
LEU A 331
None
1.27A 4n09D-5fyqA:
5.8
4n09D-5fyqA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN


(Klebsiella
pneumoniae)
PF13407
(Peripla_BP_4)
4 LEU A 315
SER A 311
LEU A 252
LEU A  49
None
1.03A 4n09D-5hsgA:
5.5
4n09D-5hsgA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j04 ENOLASE

(Synechococcus
elongatus)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 LEU A 146
SER A 178
LEU A 407
LEU A 413
None
1.32A 4n09D-5j04A:
undetectable
4n09D-5j04A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpw DYNEIN LIGHT CHAIN
TCTEX-TYPE
1,CYTOPLASMIC DYNEIN
1 INTERMEDIATE CHAIN
2


(Homo sapiens)
PF03645
(Tctex-1)
PF11540
(Dynein_IC2)
4 CYH A  95
LEU A  56
SER A  20
LEU A  53
None
1.19A 4n09D-5jpwA:
undetectable
4n09D-5jpwA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA


(Methylobacillus
flagellatus)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
4 LEU C  73
SER C  33
LEU C  29
LEU C  43
None
1.27A 4n09D-5ks8C:
2.1
4n09D-5ks8C:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1


(Escherichia
coli;
Homo sapiens)
PF00001
(7tm_1)
PF07361
(Cytochrom_B562)
4 LEU A1156
SER A1386
LEU A1195
LEU A1203
None
1.17A 4n09D-5n2sA:
undetectable
4n09D-5n2sA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE


(Zobellia
galactanivorans)
no annotation 4 LEU A 418
SER A 420
LEU A 512
LEU A 333
None
0.79A 4n09D-5opqA:
undetectable
4n09D-5opqA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 3


(Schizosaccharomyces
pombe)
no annotation 4 LEU A 385
SER A 387
LEU A 408
LEU A 422
None
0.95A 4n09D-5oqrA:
undetectable
4n09D-5oqrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc1 MATURATION PROTEIN

(Escherichia
virus MS2)
PF03863
(Phage_mat-A)
4 LEU M  65
SER M 100
LEU M 104
LEU M 111
None
1.18A 4n09D-5tc1M:
undetectable
4n09D-5tc1M:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1


(Alicyclobacillus
acidoterrestris)
no annotation 4 LEU A 847
SER A 568
LEU A 844
LEU A 879
None
1.22A 4n09D-5u30A:
undetectable
4n09D-5u30A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium)
PF02310
(B12-binding)
4 LEU A 541
SER A 594
LEU A 486
LEU A 640
EDO  A 814 (-4.8A)
None
None
None
1.27A 4n09D-5ul4A:
5.8
4n09D-5ul4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)


(Corynebacterium
freiburgense)
PF00171
(Aldedh)
PF01619
(Pro_dh)
4 LEU A 169
SER A 190
LEU A 207
LEU A 214
None
1.09A 4n09D-5ux5A:
undetectable
4n09D-5ux5A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL


(Homo sapiens)
no annotation 4 LEU A 164
SER A 226
LEU A 166
LEU A 197
None
LLP  A 280 (-3.4A)
8Z1  A 601 (-4.7A)
None
1.14A 4n09D-5v7iA:
4.7
4n09D-5v7iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wde KINESIN-LIKE PROTEIN
KIFC3


(Homo sapiens)
PF00225
(Kinesin)
4 CYH A 523
SER A 732
LEU A 606
LEU A 725
None
UNX  A 932 ( 2.7A)
None
None
1.24A 4n09D-5wdeA:
undetectable
4n09D-5wdeA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x41 COBALT ABC
TRANSPORTER
ATP-BINDING PROTEIN


(Rhodobacter
capsulatus)
PF00005
(ABC_tran)
4 LEU A  37
SER A 196
LEU A 202
LEU A 239
None
0.84A 4n09D-5x41A:
undetectable
4n09D-5x41A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c54 NUCLEOPROTEIN

(Zaire
ebolavirus)
no annotation 4 LEU A  74
SER A  72
LEU A 209
LEU A 203
None
0.96A 4n09D-6c54A:
undetectable
4n09D-6c54A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE


(Medicago
truncatula)
no annotation 4 LEU A 202
SER A 264
LEU A 204
LEU A 235
None
ACT  A 612 (-2.7A)
None
None
1.08A 4n09D-6cczA:
undetectable
4n09D-6cczA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G


(Pyrococcus
furiosus)
no annotation 4 LEU B  66
SER B  68
LEU C  83
LEU F  16
None
1.03A 4n09D-6cfwB:
undetectable
4n09D-6cfwB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens)
no annotation 4 LEU A1267
SER A1271
LEU A1141
LEU A1293
None
1.24A 4n09D-6ez8A:
undetectable
4n09D-6ez8A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4


(Mus musculus)
no annotation 4 LEU M 106
SER M 101
LEU M  73
LEU M 235
None
3PE  M 505 ( 3.8A)
None
None
0.88A 4n09D-6g2jM:
undetectable
4n09D-6g2jM:
11.90