SIMILAR PATTERNS OF AMINO ACIDS FOR 4N09_D_ADND401_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dcn | DELTA 2 CRYSTALLIN (Anasplatyrhynchos) |
PF00206(Lyase_1)PF14698(ASL_C2) | 4 | LEU A 182SER A 177LEU A 457LEU A 141 | None | 1.29A | 4n09D-1dcnA:undetectable | 4n09D-1dcnA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ej6 | LAMBDA1 (Reovirus sp.) |
no annotation | 4 | CYH B 925LEU B 997SER B 517LEU B 987 | None | 1.33A | 4n09D-1ej6B:undetectable | 4n09D-1ej6B:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f2r | INHIBITOR OFCASPASE-ACTIVATEDDNASE (Mus musculus) |
PF02017(CIDE-N) | 4 | LEU I 42SER I 44LEU I 49LEU I 61 | None | 1.30A | 4n09D-1f2rI:undetectable | 4n09D-1f2rI:14.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fuu | YEAST INITIATIONFACTOR 4A (Saccharomycescerevisiae) |
PF00270(DEAD) | 4 | CYH A 123LEU A 93LEU A 189LEU A 95 | None | 1.04A | 4n09D-1fuuA:4.2 | 4n09D-1fuuA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gqp | DOC1/APC10 (Saccharomycescerevisiae) |
PF03256(ANAPC10) | 4 | LEU A 156SER A 126LEU A 234LEU A 247 | None | 1.26A | 4n09D-1gqpA:undetectable | 4n09D-1gqpA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hkk | CHITOTRIOSIDASE-1 (Homo sapiens) |
PF00704(Glyco_hydro_18) | 4 | LEU A 127SER A 122LEU A 162LEU A 94 | None | 1.22A | 4n09D-1hkkA:3.6 | 4n09D-1hkkA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i0a | DELTA CRYSTALLIN I (Meleagrisgallopavo) |
PF00206(Lyase_1)PF14698(ASL_C2) | 4 | LEU A 180SER A 175LEU A 455LEU A 139 | None | 1.33A | 4n09D-1i0aA:undetectable | 4n09D-1i0aA:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jl5 | OUTER PROTEIN YOPM (Yersinia pestis) |
PF12468(TTSSLRR) | 4 | LEU A1109SER A1115LEU A1093LEU A1106 | None | 1.19A | 4n09D-1jl5A:undetectable | 4n09D-1jl5A:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jl5 | OUTER PROTEIN YOPM (Yersinia pestis) |
PF12468(TTSSLRR) | 4 | LEU A1136SER A1139LEU A1117LEU A1126 | None | 1.25A | 4n09D-1jl5A:undetectable | 4n09D-1jl5A:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jl5 | OUTER PROTEIN YOPM (Yersinia pestis) |
PF12468(TTSSLRR) | 4 | LEU A1213SER A1219LEU A1197LEU A1210 | None | 1.27A | 4n09D-1jl5A:undetectable | 4n09D-1jl5A:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k1b | B-CELL LYMPHOMA3-ENCODED PROTEIN (Homo sapiens) |
PF00023(Ank)PF12796(Ank_2) | 4 | LEU A 305SER A 307LEU A 316LEU A 350 | None | 1.18A | 4n09D-1k1bA:undetectable | 4n09D-1k1bA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ox4 | IMIDAZOLE GLYCEROLPHOSPHATE SYNTHASEHISHF (Saccharomycescerevisiae) |
PF00117(GATase)PF00977(His_biosynth) | 4 | LEU B 468SER B 402LEU B 454LEU B 484 | None | 1.33A | 4n09D-1ox4B:2.3 | 4n09D-1ox4B:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pdz | ENOLASE (Homarusgammarus) |
PF00113(Enolase_C)PF03952(Enolase_N) | 4 | LEU A 144SER A 176LEU A 412LEU A 418 | None | 1.24A | 4n09D-1pdzA:undetectable | 4n09D-1pdzA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qva | INITIATION FACTOR 4A (Saccharomycescerevisiae) |
PF00270(DEAD) | 4 | CYH A 123LEU A 93LEU A 189LEU A 95 | None | 1.13A | 4n09D-1qvaA:4.0 | 4n09D-1qvaA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sgj | CITRATE LYASE, BETASUBUNIT (Deinococcusradiodurans) |
PF03328(HpcH_HpaI) | 4 | LEU A 190SER A 10LEU A 7LEU A 125 | None | 0.95A | 4n09D-1sgjA:2.7 | 4n09D-1sgjA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1smt | TRANSCRIPTIONALREPRESSOR SMTB (Synechococcuselongatus) |
PF01022(HTH_5) | 4 | LEU A 88SER A 82LEU A 51LEU A 43 | None | 1.32A | 4n09D-1smtA:undetectable | 4n09D-1smtA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wb0 | CHITOTRIOSIDASE 1 (Homo sapiens) |
PF00704(Glyco_hydro_18) | 4 | LEU A 127SER A 122LEU A 162LEU A 94 | None | 1.23A | 4n09D-1wb0A:2.4 | 4n09D-1wb0A:24.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zkl | HIGH-AFFINITYCAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 7A (Homo sapiens) |
PF00233(PDEase_I) | 4 | LEU A 198SER A 172LEU A 177LEU A 194 | None | 1.17A | 4n09D-1zklA:undetectable | 4n09D-1zklA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b7h | HEMOGLOBIN ALPHACHAIN (Cerdocyon thous) |
PF00042(Globin) | 4 | LEU A 76SER A 133LEU A 66LEU A 2 | NoneHEM A 200 ( 4.8A)HEM A 200 ( 4.6A)None | 0.91A | 4n09D-2b7hA:undetectable | 4n09D-2b7hA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bex | RIBONUCLEASEINHIBITOR (Homo sapiens) |
PF13516(LRR_6) | 4 | CYH A 304LEU A 342LEU A 374LEU A 317 | None | 1.24A | 4n09D-2bexA:undetectable | 4n09D-2bexA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bnh | RIBONUCLEASEINHIBITOR (Sus scrofa) |
PF13516(LRR_6) | 4 | CYH A 300LEU A 338LEU A 370LEU A 313 | None | 1.21A | 4n09D-2bnhA:undetectable | 4n09D-2bnhA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dw6 | BLL6730 PROTEIN (Bradyrhizobiumjaponicum) |
PF13378(MR_MLE_C) | 4 | LEU A 289SER A 315LEU A 306LEU A 277 | None | 1.30A | 4n09D-2dw6A:undetectable | 4n09D-2dw6A:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eig | LECTIN (Lotustetragonolobus) |
PF00139(Lectin_legB) | 4 | LEU A 192SER A 167LEU A 227LEU A 86 | None | 1.25A | 4n09D-2eigA:undetectable | 4n09D-2eigA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g4r | MOLYBDOPTERINBIOSYNTHESIS MOGPROTEIN (Mycobacteriumtuberculosis) |
PF00994(MoCF_biosynth) | 4 | CYH A 24LEU A 128SER A 131LEU A 139 | None | 1.32A | 4n09D-2g4rA:undetectable | 4n09D-2g4rA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hes | YDR267CP (Saccharomycescerevisiae) |
PF00400(WD40) | 4 | LEU X 27SER X 40LEU X 10LEU X 304 | None | 1.33A | 4n09D-2hesX:undetectable | 4n09D-2hesX:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i3o | GAMMA-GLUTAMYLTRANSFERASE RELATEDPROTEIN (Thermoplasmaacidophilum) |
PF01019(G_glu_transpept) | 4 | LEU A 409SER A 411LEU A 439LEU A 425 | None | 1.31A | 4n09D-2i3oA:undetectable | 4n09D-2i3oA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ilx | 2',3'-CYCLIC-NUCLEOTIDE3'-PHOSPHODIESTERASE (Rattusnorvegicus) |
PF05881(CNPase) | 4 | LEU A 70SER A 18LEU A 104LEU A 153 | None | 1.29A | 4n09D-2ilxA:undetectable | 4n09D-2ilxA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p5x | N-ACETYLSEROTONINO-METHYLTRANSFERASE-LIKE PROTEIN (Homo sapiens) |
PF02545(Maf) | 4 | CYH A 205LEU A 33LEU A 17LEU A 10 | None | 1.16A | 4n09D-2p5xA:undetectable | 4n09D-2p5xA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyf | T-CELL RECEPTOR,BETA CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | LEU B 108SER B 106LEU B 74LEU B 11 | None | 1.25A | 4n09D-2pyfB:undetectable | 4n09D-2pyfB:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rt5 | MSX2-INTERACTINGPROTEIN (Homo sapiens) |
PF07744(SPOC) | 4 | LEU A3642SER A3637LEU A3647LEU A3575 | None | 1.25A | 4n09D-2rt5A:undetectable | 4n09D-2rt5A:18.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uuu | ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE (Dictyosteliumdiscoideum) |
PF01565(FAD_binding_4)PF02913(FAD-oxidase_C) | 4 | LEU A 143SER A 191LEU A 146LEU A 101 | None | 1.33A | 4n09D-2uuuA:undetectable | 4n09D-2uuuA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wui | TRANSCRIPTIONALREGULATOR (Pseudomonasaeruginosa) |
PF00440(TetR_N)PF08361(TetR_C_2) | 4 | LEU A 196SER A 198LEU A 166LEU A 85 | None | 1.33A | 4n09D-2wuiA:undetectable | 4n09D-2wuiA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xxs | PROTEIN MXIG (Shigellaflexneri) |
PF09480(PrgH) | 4 | CYH A 72LEU A 100SER A 86LEU A 23 | None | 1.22A | 4n09D-2xxsA:undetectable | 4n09D-2xxsA:14.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zf3 | HYPOTHETICAL PROTEINVIOE (Chromobacteriumviolaceum) |
no annotation | 4 | CYH A 35SER A 15LEU A 158LEU A 110 | None | 1.23A | 4n09D-2zf3A:undetectable | 4n09D-2zf3A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e4b | ALGK (Pseudomonasfluorescens) |
no annotation | 4 | LEU A 223SER A 218LEU A 240LEU A 199 | None | 1.21A | 4n09D-3e4bA:undetectable | 4n09D-3e4bA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3efb | PROBABLE SOR-OPERONREGULATOR (Shigellaflexneri) |
PF04198(Sugar-bind) | 4 | LEU A 263SER A 258LEU A 15LEU A 253 | None | 1.22A | 4n09D-3efbA:3.8 | 4n09D-3efbA:23.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3evz | METHYLTRANSFERASE (Pyrococcusfuriosus) |
PF05175(MTS) | 4 | LEU A 202SER A 239LEU A 211LEU A 187 | None | 1.25A | 4n09D-3evzA:4.8 | 4n09D-3evzA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7k | 3-METHYLITACONATEISOMERASE (Eubacteriumbarkeri) |
PF04303(PrpF) | 4 | LEU A 63SER A 61LEU A 39LEU A 22 | None | 1.23A | 4n09D-3g7kA:undetectable | 4n09D-3g7kA:24.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdj | PROBABLE ORNITHINECYCLODEAMINASE (Bordetellapertussis) |
PF02423(OCD_Mu_crystall) | 4 | CYH A 165LEU A 143LEU A 147LEU A 137 | None | 1.30A | 4n09D-3hdjA:4.6 | 4n09D-3hdjA:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hsk | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Candidaalbicans) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 4 | LEU A 102SER A 96LEU A 9LEU A 76 | None | 1.31A | 4n09D-3hskA:3.8 | 4n09D-3hskA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ijf | CYTIDINE DEAMINASE (Mycobacteriumtuberculosis) |
PF00383(dCMP_cyt_deam_1) | 4 | CYH X 59LEU X 96LEU X 119LEU X 76 | None | 1.33A | 4n09D-3ijfX:undetectable | 4n09D-3ijfX:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | U2 SMALL NUCLEARRIBONUCLEOPROTEIN A' (Schizosaccharomycespombe) |
PF01423(LSM) | 4 | LEU j 92SER j 118LEU j 69LEU j 56 | None | 1.05A | 4n09D-3jb9j:undetectable | 4n09D-3jb9j:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kl9 | GLUTAMYLAMINOPEPTIDASE (Streptococcuspneumoniae) |
PF05343(Peptidase_M42) | 4 | LEU A 207SER A 209LEU A 62LEU A 192 | None | 1.28A | 4n09D-3kl9A:2.4 | 4n09D-3kl9A:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lfk | MARR LIKE PROTEIN,TVG0766549 (Thermoplasmavolcanium) |
no annotation | 4 | LEU A 89SER A 91LEU A 77LEU A 39 | None | 1.16A | 4n09D-3lfkA:undetectable | 4n09D-3lfkA:17.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3loo | ANOPHELES GAMBIAEADENOSINE KINASE (Anophelesgambiae) |
PF00294(PfkB) | 4 | LEU A 16SER A 65LEU A 133LEU A 137 | B4P A 349 (-4.7A) CL A 351 ( 4.6A)B4P A 349 (-4.5A)None | 0.47A | 4n09D-3looA:47.9 | 4n09D-3looA:36.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ly9 | TRANSCRIPTIONALACTIVATOR CADC (Escherichiacoli) |
no annotation | 4 | LEU A 307SER A 311LEU A 231LEU A 326 | None | 1.26A | 4n09D-3ly9A:undetectable | 4n09D-3ly9A:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mn8 | LP15968P (Drosophilamelanogaster) |
PF00246(Peptidase_M14)PF13620(CarboxypepD_reg) | 4 | CYH A 299SER A 213LEU A 332LEU A 377 | None | 1.27A | 4n09D-3mn8A:2.4 | 4n09D-3mn8A:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mn8 | LP15968P (Drosophilamelanogaster) |
PF00246(Peptidase_M14)PF13620(CarboxypepD_reg) | 4 | LEU A 251SER A 213LEU A 332LEU A 377 | None | 1.13A | 4n09D-3mn8A:2.4 | 4n09D-3mn8A:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nwn | KINESIN-LIKE PROTEINKIF9 (Homo sapiens) |
PF00225(Kinesin) | 4 | CYH A 295LEU A 275SER A 271LEU A 301 | None | 1.14A | 4n09D-3nwnA:undetectable | 4n09D-3nwnA:20.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3otx | ADENOSINE KINASE,PUTATIVE (Trypanosomabrucei) |
PF00294(PfkB) | 5 | CYH A 12LEU A 15SER A 64LEU A 134LEU A 138 | AP5 A 346 (-3.6A)AP5 A 346 (-4.4A) NA A 347 (-4.8A)AP5 A 346 ( 4.4A)None | 0.26A | 4n09D-3otxA:58.3 | 4n09D-3otxA:99.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s30 | HYPOTHETICALGLYCOSIDE HYDROLASE (Bacteroidesvulgatus) |
PF13201(PCMD) | 4 | LEU A 150SER A 163LEU A 160LEU A 195 | None | 1.25A | 4n09D-3s30A:undetectable | 4n09D-3s30A:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s5k | FALCILYSIN (Plasmodiumfalciparum) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF08367(M16C_assoc) | 4 | LEU A1015SER A1060LEU A1022LEU A1156 | None | 1.19A | 4n09D-3s5kA:undetectable | 4n09D-3s5kA:13.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsr | RIBONUCLEASEINHIBITOR (Mus musculus) |
PF13516(LRR_6) | 4 | CYH E 300LEU E 338LEU E 370LEU E 313 | None | 1.19A | 4n09D-3tsrE:undetectable | 4n09D-3tsrE:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d3c | SFN68 FAB (Oryctolaguscuniculus) |
PF07654(C1-set)PF07686(V-set) | 4 | LEU L 2SER L 28LEU L 32LEU L 4 | None | 1.12A | 4n09D-4d3cL:undetectable | 4n09D-4d3cL:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ewj | ENOLASE 2 (Streptococcussuis) |
PF00113(Enolase_C)PF03952(Enolase_N) | 4 | LEU A 142SER A 174LEU A 412LEU A 418 | None | 1.27A | 4n09D-4ewjA:undetectable | 4n09D-4ewjA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ft2 | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 (Zea mays) |
PF00145(DNA_methylase)PF00385(Chromo)PF01426(BAH) | 4 | CYH A 512SER A 354LEU A 359LEU A 865 | None | 0.86A | 4n09D-4ft2A:5.6 | 4n09D-4ft2A:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k37 | ANAEROBICSULFATASE-MATURATINGENZYME (Clostridiumperfringens) |
PF04055(Radical_SAM)PF13186(SPASM)PF13353(Fer4_12) | 4 | LEU A 112SER A 107LEU A 152LEU A 97 | None | 1.04A | 4n09D-4k37A:2.5 | 4n09D-4k37A:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpp | PUTATIVEUNCHARACTERIZEDPROTEIN (Archaeoglobusfulgidus) |
PF01699(Na_Ca_ex) | 4 | LEU A 145SER A 280LEU A 140LEU A 331 | None | 1.29A | 4n09D-4kppA:undetectable | 4n09D-4kppA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lry | PTS-DEPENDENTDIHYDROXYACETONEKINASE,DIHYDROXYACETONE-BINDING SUBUNIT DHAK (Escherichiacoli) |
PF02733(Dak1) | 4 | CYH A 304LEU A 272LEU A 333LEU A 242 | None | 1.10A | 4n09D-4lryA:2.8 | 4n09D-4lryA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m0m | PUTATIVEUNCHARACTERIZEDPROTEIN (Legionellapneumophila) |
no annotation | 4 | LEU A 438SER A 440LEU A 464LEU A 482 | None | 1.31A | 4n09D-4m0mA:4.9 | 4n09D-4m0mA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mdr | AP-4 COMPLEX SUBUNITMU-1 (Homo sapiens) |
PF00928(Adap_comp_sub) | 4 | LEU A 315SER A 301LEU A 377LEU A 334 | None | 1.11A | 4n09D-4mdrA:undetectable | 4n09D-4mdrA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mhp | GLUTAMINYL CYCLASE,PUTATIVE (Ixodesscapularis) |
PF04389(Peptidase_M28) | 4 | LEU A 163SER A 158LEU A 88LEU A 175 | None | 1.07A | 4n09D-4mhpA:undetectable | 4n09D-4mhpA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nzk | UNCHARACTERIZEDPROTEIN ([Eubacterium]siraeum) |
PF14286(DHHW) | 4 | CYH A 209LEU A 314SER A 332LEU A 361 | None | 1.27A | 4n09D-4nzkA:2.5 | 4n09D-4nzkA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4peq | RIBONUCLEASE/ANGIOGENIN INHIBITOR 1 (Bos taurus) |
PF13516(LRR_6) | 4 | CYH B 300LEU B 338LEU B 370LEU B 313 | None | 1.26A | 4n09D-4peqB:undetectable | 4n09D-4peqB:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4peq | RIBONUCLEASE/ANGIOGENIN INHIBITOR 1 (Bos taurus) |
PF13516(LRR_6) | 4 | CYH B 324LEU B 343LEU B 313LEU B 356 | None | 1.26A | 4n09D-4peqB:undetectable | 4n09D-4peqB:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4peq | RIBONUCLEASE/ANGIOGENIN INHIBITOR 1 (Bos taurus) |
PF13516(LRR_6) | 4 | CYH B 357LEU B 395LEU B 427LEU B 370 | None | 1.26A | 4n09D-4peqB:undetectable | 4n09D-4peqB:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4per | RIBONUCLEASEINHIBITOR (Gallus gallus) |
PF13516(LRR_6) | 4 | CYH A 300LEU A 338LEU A 370LEU A 313 | None | 1.30A | 4n09D-4perA:undetectable | 4n09D-4perA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4psp | ALPHA-FUCOSIDASEGH29 (Fusariumgraminearum) |
PF01120(Alpha_L_fucos)PF16757(Fucosidase_C) | 4 | LEU A 198SER A 190LEU A 195LEU A 206 | None | 1.04A | 4n09D-4pspA:2.9 | 4n09D-4pspA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pxh | PEPTIDE SYNTHETASE (Streptomycessp. Acta 2897) |
PF00550(PP-binding) | 4 | LEU B 60SER B 50LEU B 62LEU B 74 | None | 1.07A | 4n09D-4pxhB:undetectable | 4n09D-4pxhB:13.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qdg | PUTATIVE ADHESIN (Bacteroidesthetaiotaomicron) |
PF08842(Mfa2) | 4 | LEU A 97SER A 44LEU A 161LEU A 68 | None | 1.22A | 4n09D-4qdgA:undetectable | 4n09D-4qdgA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qdn | FLAGELLAR PROTEINFLGJ [PEPTIDOGLYCANHYDROLASE] (Thermotogamaritima) |
PF01832(Glucosaminidase) | 4 | LEU A 27SER A 12LEU A 46LEU A 89 | None | 1.05A | 4n09D-4qdnA:undetectable | 4n09D-4qdnA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qfv | ANK-N5C-281 (syntheticconstruct) |
PF00023(Ank)PF12796(Ank_2)PF13637(Ank_4) | 4 | LEU A 174SER A 176LEU A 185LEU A 222 | None | 1.24A | 4n09D-4qfvA:undetectable | 4n09D-4qfvA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tlv | ADP-RIBOSYLATINGTOXIN CARDS (Mycoplasmapneumoniae) |
PF02917(Pertussis_S1) | 4 | LEU A 38SER A 225LEU A 123LEU A 260 | None | 1.27A | 4n09D-4tlvA:undetectable | 4n09D-4tlvA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8j | PESTICIDAL CRYSTALPROTEIN CRY1AC (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 4 | LEU A 656SER A 669LEU A 662LEU A 618 | None | 1.09A | 4n09D-4w8jA:undetectable | 4n09D-4w8jA:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yac | CALPHA-DEHYDROGENASE (Sphingobium sp.SYK-6) |
PF00106(adh_short) | 4 | LEU A 185SER A 144LEU A 250LEU A 234 | None | 0.85A | 4n09D-4yacA:7.8 | 4n09D-4yacA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z17 | ENOLASE (Chloroflexusaurantiacus) |
PF00113(Enolase_C)PF03952(Enolase_N) | 4 | LEU A 143SER A 175LEU A 406LEU A 412 | None | 1.22A | 4n09D-4z17A:undetectable | 4n09D-4z17A:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z61 | PHYTOSULFOKINERECEPTOR 1 (Daucus carota) |
PF00560(LRR_1)PF13855(LRR_8) | 4 | LEU A 451SER A 446LEU A 469LEU A 430 | None | 1.24A | 4n09D-4z61A:undetectable | 4n09D-4z61A:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zke | SUPERKILLER PROTEIN7 (Saccharomycescerevisiae) |
PF00009(GTP_EFTU) | 4 | LEU A 687SER A 697LEU A 704LEU A 674 | LEU A 687 ( 0.6A)SER A 697 ( 0.0A)LEU A 704 ( 0.6A)LEU A 674 ( 0.6A) | 1.10A | 4n09D-4zkeA:3.7 | 4n09D-4zkeA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zoq | INTRACELLULAR SERINEPROTEASE (Bacilluslicheniformis) |
PF00082(Peptidase_S8) | 4 | LEU I 345SER I 370LEU I 377LEU I 330 | None | 1.02A | 4n09D-4zoqI:4.9 | 4n09D-4zoqI:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by7 | 3-OXOACYL-ACPSYNTHASE III (Verrucosisporamaris) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | LEU A 167SER A -10LEU A 127LEU A 111 | None | 1.13A | 4n09D-5by7A:undetectable | 4n09D-5by7A:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fyq | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-2 (Homo sapiens) |
PF02146(SIR2) | 4 | CYH A 148LEU A 258LEU A 284LEU A 331 | None | 1.27A | 4n09D-5fyqA:5.8 | 4n09D-5fyqA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hsg | PUTATIVE ABCTRANSPORTER,NUCLEOTIDEBINDING/ATPASEPROTEIN (Klebsiellapneumoniae) |
PF13407(Peripla_BP_4) | 4 | LEU A 315SER A 311LEU A 252LEU A 49 | None | 1.03A | 4n09D-5hsgA:5.5 | 4n09D-5hsgA:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j04 | ENOLASE (Synechococcuselongatus) |
PF00113(Enolase_C)PF03952(Enolase_N) | 4 | LEU A 146SER A 178LEU A 407LEU A 413 | None | 1.32A | 4n09D-5j04A:undetectable | 4n09D-5j04A:23.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jpw | DYNEIN LIGHT CHAINTCTEX-TYPE1,CYTOPLASMIC DYNEIN1 INTERMEDIATE CHAIN2 (Homo sapiens) |
PF03645(Tctex-1)PF11540(Dynein_IC2) | 4 | CYH A 95LEU A 56SER A 20LEU A 53 | None | 1.19A | 4n09D-5jpwA:undetectable | 4n09D-5jpwA:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ks8 | PYRUVATE CARBOXYLASESUBUNIT BETA (Methylobacillusflagellatus) |
PF00364(Biotin_lipoyl)PF00682(HMGL-like)PF02436(PYC_OADA) | 4 | LEU C 73SER C 33LEU C 29LEU C 43 | None | 1.27A | 4n09D-5ks8C:2.1 | 4n09D-5ks8C:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n2s | SOLUBLE CYTOCHROMEB562,ADENOSINERECEPTOR A1 (Escherichiacoli;Homo sapiens) |
PF00001(7tm_1)PF07361(Cytochrom_B562) | 4 | LEU A1156SER A1386LEU A1195LEU A1203 | None | 1.17A | 4n09D-5n2sA:undetectable | 4n09D-5n2sA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5opq | 3,6-ANHYDRO-D-GALACTOSIDASE (Zobelliagalactanivorans) |
no annotation | 4 | LEU A 418SER A 420LEU A 512LEU A 333 | None | 0.79A | 4n09D-5opqA:undetectable | 4n09D-5opqA:12.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oqr | CONDENSIN COMPLEXSUBUNIT 3 (Schizosaccharomycespombe) |
no annotation | 4 | LEU A 385SER A 387LEU A 408LEU A 422 | None | 0.95A | 4n09D-5oqrA:undetectable | 4n09D-5oqrA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tc1 | MATURATION PROTEIN (Escherichiavirus MS2) |
PF03863(Phage_mat-A) | 4 | LEU M 65SER M 100LEU M 104LEU M 111 | None | 1.18A | 4n09D-5tc1M:undetectable | 4n09D-5tc1M:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u30 | CRISPR-ASSOCIATEDENDONUCLEASE C2C1 (Alicyclobacillusacidoterrestris) |
no annotation | 4 | LEU A 847SER A 568LEU A 844LEU A 879 | None | 1.22A | 4n09D-5u30A:undetectable | 4n09D-5u30A:15.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ul4 | OXSB PROTEIN (Bacillusmegaterium) |
PF02310(B12-binding) | 4 | LEU A 541SER A 594LEU A 486LEU A 640 | EDO A 814 (-4.8A)NoneNoneNone | 1.27A | 4n09D-5ul4A:5.8 | 4n09D-5ul4A:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ux5 | BIFUNCTIONAL PROTEINPROLINE UTILIZATIONA (PUTA) (Corynebacteriumfreiburgense) |
PF00171(Aldedh)PF01619(Pro_dh) | 4 | LEU A 169SER A 190LEU A 207LEU A 214 | None | 1.09A | 4n09D-5ux5A:undetectable | 4n09D-5ux5A:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v7i | SERINEHYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL (Homo sapiens) |
no annotation | 4 | LEU A 164SER A 226LEU A 166LEU A 197 | NoneLLP A 280 (-3.4A)8Z1 A 601 (-4.7A)None | 1.14A | 4n09D-5v7iA:4.7 | 4n09D-5v7iA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wde | KINESIN-LIKE PROTEINKIFC3 (Homo sapiens) |
PF00225(Kinesin) | 4 | CYH A 523SER A 732LEU A 606LEU A 725 | NoneUNX A 932 ( 2.7A)NoneNone | 1.24A | 4n09D-5wdeA:undetectable | 4n09D-5wdeA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x41 | COBALT ABCTRANSPORTERATP-BINDING PROTEIN (Rhodobactercapsulatus) |
PF00005(ABC_tran) | 4 | LEU A 37SER A 196LEU A 202LEU A 239 | None | 0.84A | 4n09D-5x41A:undetectable | 4n09D-5x41A:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c54 | NUCLEOPROTEIN (Zaireebolavirus) |
no annotation | 4 | LEU A 74SER A 72LEU A 209LEU A 203 | None | 0.96A | 4n09D-6c54A:undetectable | 4n09D-6c54A:14.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ccz | SERINEHYDROXYMETHYLTRANSFERASE (Medicagotruncatula) |
no annotation | 4 | LEU A 202SER A 264LEU A 204LEU A 235 | NoneACT A 612 (-2.7A)NoneNone | 1.08A | 4n09D-6cczA:undetectable | 4n09D-6cczA:12.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfw | MONOVALENT CATION/H+ANTIPORTER SUBUNIT BMONOVALENT CATION/H+ANTIPORTER SUBUNIT FMONOVALENT CATION/H+ANTIPORTER SUBUNIT G (Pyrococcusfuriosus) |
no annotation | 4 | LEU B 66SER B 68LEU C 83LEU F 16 | None | 1.03A | 4n09D-6cfwB:undetectable | 4n09D-6cfwB:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ez8 | HUNTINGTIN (Homo sapiens) |
no annotation | 4 | LEU A1267SER A1271LEU A1141LEU A1293 | None | 1.24A | 4n09D-6ez8A:undetectable | 4n09D-6ez8A:8.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g2j | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN4 (Mus musculus) |
no annotation | 4 | LEU M 106SER M 101LEU M 73LEU M 235 | None3PE M 505 ( 3.8A)NoneNone | 0.88A | 4n09D-6g2jM:undetectable | 4n09D-6g2jM:11.90 |