SIMILAR PATTERNS OF AMINO ACIDS FOR 4N09_B_ADNB401_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)


(Hepacivirus C)
PF00998
(RdRP_3)
4 LEU A 419
SER A 478
LEU A 497
ASN A 369
None
1.16A 4n09B-1csjA:
undetectable
4n09B-1csjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dc1 BSOBI RESTRICTION
ENDONUCLEASE


(Geobacillus
stearothermophilus)
PF09194
(Endonuc-BsobI)
4 LEU A 114
SER A  76
LEU A  49
ASN A  96
None
1.13A 4n09B-1dc1A:
undetectable
4n09B-1dc1A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqp DOC1/APC10

(Saccharomyces
cerevisiae)
PF03256
(ANAPC10)
4 LEU A 156
SER A 126
LEU A 234
LEU A 247
None
1.27A 4n09B-1gqpA:
undetectable
4n09B-1gqpA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens)
PF00704
(Glyco_hydro_18)
4 LEU A 127
SER A 122
LEU A 162
LEU A  94
None
1.22A 4n09B-1hkkA:
undetectable
4n09B-1hkkA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihm CAPSID PROTEIN

(Norwalk virus)
PF00915
(Calici_coat)
PF08435
(Calici_coat_C)
4 LEU A1418
SER A1262
LEU A1436
ASN A1259
None
1.23A 4n09B-1ihmA:
undetectable
4n09B-1ihmA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis)
PF12468
(TTSSLRR)
4 LEU A1109
SER A1115
LEU A1093
LEU A1106
None
1.19A 4n09B-1jl5A:
undetectable
4n09B-1jl5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis)
PF12468
(TTSSLRR)
4 LEU A1136
SER A1139
LEU A1117
LEU A1126
None
1.24A 4n09B-1jl5A:
undetectable
4n09B-1jl5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis)
PF12468
(TTSSLRR)
4 LEU A1213
SER A1219
LEU A1197
LEU A1210
None
1.27A 4n09B-1jl5A:
undetectable
4n09B-1jl5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1b B-CELL LYMPHOMA
3-ENCODED PROTEIN


(Homo sapiens)
PF00023
(Ank)
PF12796
(Ank_2)
4 LEU A 305
SER A 307
LEU A 316
LEU A 350
None
1.18A 4n09B-1k1bA:
undetectable
4n09B-1k1bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kvk MEVALONATE KINASE

(Rattus
norvegicus)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
4 LEU A  35
SER A 145
LEU A 234
ASN A  55
None
ATP  A 535 (-2.9A)
None
ATP  A 535 (-4.0A)
1.02A 4n09B-1kvkA:
undetectable
4n09B-1kvkA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lk3 9D7 HEAVY CHAIN

(Rattus
norvegicus)
PF07654
(C1-set)
PF07686
(V-set)
4 LEU H  20
SER H  95
LEU H 114
LEU H  83
None
1.28A 4n09B-1lk3H:
undetectable
4n09B-1lk3H:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdz ENOLASE

(Homarus
gammarus)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 LEU A 144
SER A 176
LEU A 412
LEU A 418
None
1.25A 4n09B-1pdzA:
undetectable
4n09B-1pdzA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgj CITRATE LYASE, BETA
SUBUNIT


(Deinococcus
radiodurans)
PF03328
(HpcH_HpaI)
4 LEU A 190
SER A  10
LEU A   7
LEU A 125
None
0.93A 4n09B-1sgjA:
2.5
4n09B-1sgjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens)
PF00704
(Glyco_hydro_18)
4 LEU A 127
SER A 122
LEU A 162
LEU A  94
None
1.23A 4n09B-1wb0A:
2.4
4n09B-1wb0A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A


(Homo sapiens)
PF00233
(PDEase_I)
4 LEU A 198
SER A 172
LEU A 177
LEU A 194
None
1.19A 4n09B-1zklA:
undetectable
4n09B-1zklA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE


(Pseudomonas
putida;
Spinacia
oleracea)
PF01070
(FMN_dh)
4 LEU A 306
LEU A 311
LEU A 329
ASN A  83
None
1.28A 4n09B-2a7nA:
2.3
4n09B-2a7nA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7h HEMOGLOBIN ALPHA
CHAIN


(Cerdocyon thous)
PF00042
(Globin)
4 LEU A  76
SER A 133
LEU A  66
LEU A   2
None
HEM  A 200 ( 4.8A)
HEM  A 200 ( 4.6A)
None
0.91A 4n09B-2b7hA:
undetectable
4n09B-2b7hA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eig LECTIN

(Lotus
tetragonolobus)
PF00139
(Lectin_legB)
4 LEU A 192
SER A 167
LEU A 227
LEU A  86
None
1.25A 4n09B-2eigA:
undetectable
4n09B-2eigA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE


(Thermus
thermophilus)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
4 LEU A  89
LEU A 285
LEU A 270
ASN A 228
None
0.92A 4n09B-2elcA:
6.1
4n09B-2elcA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqq PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Streptomyces
coelicolor)
PF00027
(cNMP_binding)
4 LEU A 101
SER A  27
LEU A  47
LEU A  37
None
1.13A 4n09B-2pqqA:
undetectable
4n09B-2pqqA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyf T-CELL RECEPTOR,
BETA CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 LEU B 108
SER B 106
LEU B  74
LEU B  11
None
1.25A 4n09B-2pyfB:
undetectable
4n09B-2pyfB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rt5 MSX2-INTERACTING
PROTEIN


(Homo sapiens)
PF07744
(SPOC)
4 LEU A3642
SER A3637
LEU A3647
LEU A3575
None
1.25A 4n09B-2rt5A:
undetectable
4n09B-2rt5A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2


(Saccharomyces
cerevisiae)
PF03198
(Glyco_hydro_72)
PF07983
(X8)
4 LEU A 418
SER A 416
LEU A 468
ASN A 144
None
1.04A 4n09B-2w61A:
2.9
4n09B-2w61A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE


(Amycolatopsis
orientalis)
PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N)
4 LEU A 823
SER A 859
LEU A 868
ASN A 890
None
1.27A 4n09B-2x05A:
undetectable
4n09B-2x05A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z80 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B


(Eptatretus
burgeri;
Homo sapiens)
PF11921
(DUF3439)
PF13855
(LRR_8)
4 LEU A  43
SER A  60
LEU A  28
ASN A 110
None
0.98A 4n09B-2z80A:
undetectable
4n09B-2z80A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zet MELANOPHILIN

(Mus musculus)
PF02318
(FYVE_2)
4 LEU C  59
SER C  54
LEU C  86
LEU C  68
None
1.11A 4n09B-2zetC:
undetectable
4n09B-2zetC:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4b ALGK

(Pseudomonas
fluorescens)
no annotation 4 LEU A 223
SER A 218
LEU A 240
LEU A 199
None
1.20A 4n09B-3e4bA:
undetectable
4n09B-3e4bA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN


(Homo sapiens)
PF08324
(PUL)
4 LEU A 555
LEU A 614
LEU A 576
ASN A 655
None
1.00A 4n09B-3ebbA:
undetectable
4n09B-3ebbA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efb PROBABLE SOR-OPERON
REGULATOR


(Shigella
flexneri)
PF04198
(Sugar-bind)
4 LEU A 263
SER A 258
LEU A  15
LEU A 253
None
1.24A 4n09B-3efbA:
4.1
4n09B-3efbA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evz METHYLTRANSFERASE

(Pyrococcus
furiosus)
PF05175
(MTS)
4 LEU A 202
SER A 239
LEU A 211
LEU A 187
None
1.25A 4n09B-3evzA:
5.4
4n09B-3evzA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7k 3-METHYLITACONATE
ISOMERASE


(Eubacterium
barkeri)
PF04303
(PrpF)
4 LEU A  63
SER A  61
LEU A  39
LEU A  22
None
1.22A 4n09B-3g7kA:
undetectable
4n09B-3g7kA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdc MULTICOPPER OXIDASE

(Arthrobacter
sp. FB24)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 SER A 195
LEU A 224
LEU A 220
ASN A 191
None
1.18A 4n09B-3gdcA:
undetectable
4n09B-3gdcA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana)
PF13847
(Methyltransf_31)
4 SER A 486
LEU A 387
LEU A 373
ASN A 479
None
None
None
U  B   9 ( 4.2A)
1.20A 4n09B-3htxA:
4.2
4n09B-3htxA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN


(Staphylococcus
haemolyticus)
PF13377
(Peripla_BP_3)
4 LEU A  88
LEU A 258
LEU A  25
ASN A 124
None
1.20A 4n09B-3huuA:
2.7
4n09B-3huuA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE


(Bacillus
anthracis)
PF13561
(adh_short_C2)
4 LEU A  76
LEU A  92
LEU A  80
ASN A  94
LEU  A  76 ( 0.6A)
LEU  A  92 ( 0.6A)
LEU  A  80 ( 0.5A)
ASN  A  94 ( 0.6A)
0.95A 4n09B-3iccA:
7.8
4n09B-3iccA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivu HOMOCITRATE
SYNTHASE,
MITOCHONDRIAL


(Schizosaccharomyces
pombe)
PF00682
(HMGL-like)
4 LEU A 290
LEU A 252
LEU A  65
ASN A 306
None
0.92A 4n09B-3ivuA:
2.6
4n09B-3ivuA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 U2 SMALL NUCLEAR
RIBONUCLEOPROTEIN A'


(Schizosaccharomyces
pombe)
PF01423
(LSM)
4 LEU j  92
SER j 118
LEU j  69
LEU j  56
None
1.06A 4n09B-3jb9j:
undetectable
4n09B-3jb9j:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcu OXYGEN-EVOLVING
ENHANCER PROTEIN 2,
CHLOROPLASTIC


(Spinacia
oleracea)
PF01789
(PsbP)
4 LEU P  88
SER P 110
LEU P 132
LEU P  81
None
1.17A 4n09B-3jcuP:
undetectable
4n09B-3jcuP:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k33 DEATH ON CURING
PROTEIN


(Escherichia
virus P1)
PF02661
(Fic)
4 LEU A  81
SER A  79
LEU A 118
ASN A  16
None
1.15A 4n09B-3k33A:
undetectable
4n09B-3k33A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE


(Streptococcus
pneumoniae)
PF05343
(Peptidase_M42)
4 LEU A 207
SER A 209
LEU A  62
LEU A 192
None
1.26A 4n09B-3kl9A:
2.2
4n09B-3kl9A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfk MARR LIKE PROTEIN,
TVG0766549


(Thermoplasma
volcanium)
no annotation 4 LEU A  89
SER A  91
LEU A  77
LEU A  39
None
1.15A 4n09B-3lfkA:
undetectable
4n09B-3lfkA:
17.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE


(Anopheles
gambiae)
PF00294
(PfkB)
4 LEU A  16
SER A  65
LEU A 133
LEU A 137
B4P  A 349 (-4.7A)
CL  A 351 ( 4.6A)
B4P  A 349 (-4.5A)
None
0.45A 4n09B-3looA:
48.0
4n09B-3looA:
36.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn8 LP15968P

(Drosophila
melanogaster)
PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg)
4 LEU A 251
SER A 213
LEU A 332
LEU A 377
None
1.13A 4n09B-3mn8A:
2.4
4n09B-3mn8A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndp ADENYLATE KINASE
ISOENZYME 4


(Homo sapiens)
PF00406
(ADK)
PF05191
(ADK_lid)
4 LEU A  77
LEU A  72
LEU A 100
ASN A  43
None
1.14A 4n09B-3ndpA:
4.1
4n09B-3ndpA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6


(Homo sapiens)
PF00069
(Pkinase)
PF00615
(RGS)
4 LEU A 171
LEU A  66
LEU A  49
ASN A 525
None
1.07A 4n09B-3nyoA:
undetectable
4n09B-3nyoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1


(Anopheles
gambiae)
PF00560
(LRR_1)
4 LEU A  98
LEU A 109
LEU A  76
ASN A 131
None
1.19A 4n09B-3ojaA:
undetectable
4n09B-3ojaA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3otx ADENOSINE KINASE,
PUTATIVE


(Trypanosoma
brucei)
PF00294
(PfkB)
4 LEU A  15
SER A  64
LEU A 134
LEU A 138
AP5  A 346 (-4.4A)
NA  A 347 (-4.8A)
AP5  A 346 ( 4.4A)
None
0.22A 4n09B-3otxA:
58.2
4n09B-3otxA:
99.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgh RNA-DIRECTED RNA
POLYMERASE


(Hepacivirus C)
PF00998
(RdRP_3)
4 LEU A 419
SER A 478
LEU A 497
ASN A 369
None
1.17A 4n09B-3qghA:
undetectable
4n09B-3qghA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlf MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALG


(Escherichia
coli)
PF00528
(BPD_transp_1)
4 LEU G 236
SER G 234
LEU G 137
LEU G 156
None
1.07A 4n09B-3rlfG:
undetectable
4n09B-3rlfG:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s30 HYPOTHETICAL
GLYCOSIDE HYDROLASE


(Bacteroides
vulgatus)
PF13201
(PCMD)
4 LEU A 150
SER A 163
LEU A 160
LEU A 195
None
1.24A 4n09B-3s30A:
undetectable
4n09B-3s30A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc)
4 LEU A1015
SER A1060
LEU A1022
LEU A1156
None
1.18A 4n09B-3s5kA:
undetectable
4n09B-3s5kA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga)
PF00704
(Glyco_hydro_18)
4 LEU A 113
LEU A  71
LEU A 102
ASN A 321
None
1.26A 4n09B-4a5qA:
undetectable
4n09B-4a5qA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3c SFN68 FAB

(Oryctolagus
cuniculus)
PF07654
(C1-set)
PF07686
(V-set)
4 LEU L   2
SER L  28
LEU L  32
LEU L   4
None
1.14A 4n09B-4d3cL:
undetectable
4n09B-4d3cL:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewj ENOLASE 2

(Streptococcus
suis)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 LEU A 142
SER A 174
LEU A 412
LEU A 418
None
1.28A 4n09B-4ewjA:
undetectable
4n09B-4ewjA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae)
PF11894
(Nup192)
4 LEU A 145
LEU A 193
LEU A 216
ASN A  36
None
0.96A 4n09B-4ifqA:
undetectable
4n09B-4ifqA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE


(Paenibacillus
macerans)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
4 LEU A 614
SER A 642
LEU A 649
ASN A 581
None
1.05A 4n09B-4jclA:
2.3
4n09B-4jclA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k37 ANAEROBIC
SULFATASE-MATURATING
ENZYME


(Clostridium
perfringens)
PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12)
4 LEU A 112
SER A 107
LEU A 152
LEU A  97
None
1.02A 4n09B-4k37A:
2.8
4n09B-4k37A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lkr PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE


(Shewanella
oneidensis)
PF01048
(PNP_UDP_1)
4 LEU A 197
SER A 132
LEU A 105
ASN A 234
None
1.28A 4n09B-4lkrA:
undetectable
4n09B-4lkrA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1


(Arabidopsis
thaliana)
no annotation 4 LEU D 139
SER D 120
LEU D  94
LEU D 136
None
1.26A 4n09B-4m7eD:
undetectable
4n09B-4m7eD:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdr AP-4 COMPLEX SUBUNIT
MU-1


(Homo sapiens)
PF00928
(Adap_comp_sub)
4 LEU A 315
SER A 301
LEU A 377
LEU A 334
None
1.09A 4n09B-4mdrA:
undetectable
4n09B-4mdrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhp GLUTAMINYL CYCLASE,
PUTATIVE


(Ixodes
scapularis)
PF04389
(Peptidase_M28)
4 LEU A 163
SER A 158
LEU A  88
LEU A 175
None
1.08A 4n09B-4mhpA:
undetectable
4n09B-4mhpA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae)
PF00873
(ACR_tran)
4 SER A 721
LEU A 718
LEU A 692
ASN A 618
None
1.08A 4n09B-4mt1A:
undetectable
4n09B-4mt1A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT


(Rhodopseudomonas
palustris)
PF03480
(DctP)
4 LEU A  97
LEU A 100
LEU A  84
ASN A 112
None
0.99A 4n09B-4oanA:
undetectable
4n09B-4oanA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica)
PF12468
(TTSSLRR)
4 LEU A 325
SER A 341
LEU A 308
ASN A 383
None
1.13A 4n09B-4ow2A:
undetectable
4n09B-4ow2A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica)
PF12468
(TTSSLRR)
4 LEU A 385
SER A 401
LEU A 368
ASN A 443
None
1.14A 4n09B-4ow2A:
undetectable
4n09B-4ow2A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29


(Fusarium
graminearum)
PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C)
4 LEU A 198
SER A 190
LEU A 195
LEU A 206
None
1.02A 4n09B-4pspA:
2.6
4n09B-4pspA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdn FLAGELLAR PROTEIN
FLGJ [PEPTIDOGLYCAN
HYDROLASE]


(Thermotoga
maritima)
PF01832
(Glucosaminidase)
4 LEU A  27
SER A  12
LEU A  46
LEU A  89
None
1.06A 4n09B-4qdnA:
undetectable
4n09B-4qdnA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfv ANK-N5C-281

(synthetic
construct)
PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
4 LEU A 174
SER A 176
LEU A 185
LEU A 222
None
1.24A 4n09B-4qfvA:
undetectable
4n09B-4qfvA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlv ADP-RIBOSYLATING
TOXIN CARDS


(Mycoplasma
pneumoniae)
PF02917
(Pertussis_S1)
4 LEU A  38
SER A 225
LEU A 123
LEU A 260
None
1.28A 4n09B-4tlvA:
undetectable
4n09B-4tlvA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
4 LEU A 656
SER A 669
LEU A 662
LEU A 618
None
1.11A 4n09B-4w8jA:
undetectable
4n09B-4w8jA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yac C
ALPHA-DEHYDROGENASE


(Sphingobium sp.
SYK-6)
PF00106
(adh_short)
4 LEU A 185
SER A 144
LEU A 250
LEU A 234
None
0.85A 4n09B-4yacA:
7.5
4n09B-4yacA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z17 ENOLASE

(Chloroflexus
aurantiacus)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 LEU A 143
SER A 175
LEU A 406
LEU A 412
None
1.22A 4n09B-4z17A:
undetectable
4n09B-4z17A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1


(Daucus carota)
PF00560
(LRR_1)
PF13855
(LRR_8)
4 LEU A 451
SER A 446
LEU A 469
LEU A 430
None
1.24A 4n09B-4z61A:
undetectable
4n09B-4z61A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7


(Saccharomyces
cerevisiae)
PF00009
(GTP_EFTU)
4 LEU A 687
SER A 697
LEU A 704
LEU A 674
LEU  A 687 ( 0.6A)
SER  A 697 ( 0.0A)
LEU  A 704 ( 0.6A)
LEU  A 674 ( 0.6A)
1.09A 4n09B-4zkeA:
4.1
4n09B-4zkeA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoq INTRACELLULAR SERINE
PROTEASE


(Bacillus
licheniformis)
PF00082
(Peptidase_S8)
4 LEU I 345
SER I 370
LEU I 377
LEU I 330
None
1.01A 4n09B-4zoqI:
5.5
4n09B-4zoqI:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by7 3-OXOACYL-ACP
SYNTHASE III


(Verrucosispora
maris)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 LEU A 167
SER A -10
LEU A 127
LEU A 111
None
1.14A 4n09B-5by7A:
undetectable
4n09B-5by7A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus)
PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N)
4 LEU A 171
SER A 175
LEU A 538
ASN A 542
None
1.04A 4n09B-5df0A:
4.0
4n09B-5df0A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
4 LEU A 359
SER A 283
LEU A  17
ASN A 158
None
None
None
GOL  A 703 ( 4.0A)
1.16A 4n09B-5dfaA:
3.8
4n09B-5dfaA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE


(Plasmodium
vivax)
PF00027
(cNMP_binding)
PF00069
(Pkinase)
4 LEU A 658
LEU A 648
LEU A 715
ASN A 589
None
0.88A 4n09B-5ezrA:
undetectable
4n09B-5ezrA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb1 NUCLEOPORIN NUP170

(Chaetomium
thermophilum)
PF03177
(Nucleoporin_C)
4 LEU A1244
SER A1246
LEU A1291
ASN A1252
None
1.23A 4n09B-5hb1A:
undetectable
4n09B-5hb1A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN


(Klebsiella
pneumoniae)
PF13407
(Peripla_BP_4)
4 LEU A 315
SER A 311
LEU A 252
LEU A  49
None
1.04A 4n09B-5hsgA:
5.6
4n09B-5hsgA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA


(Methylobacillus
flagellatus)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
4 LEU C  73
SER C  33
LEU C  29
LEU C  43
None
1.24A 4n09B-5ks8C:
2.5
4n09B-5ks8C:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldt MOMP PORIN

(Campylobacter
jejuni)
PF05538
(Campylo_MOMP)
4 LEU A 310
SER A 308
LEU A 297
ASN A  32
None
1.15A 4n09B-5ldtA:
undetectable
4n09B-5ldtA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lt9 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTB


(Pseudomonas
aeruginosa)
PF02743
(dCache_1)
4 LEU A  46
SER A 261
LEU A  42
ASN A 184
None
0.98A 4n09B-5lt9A:
undetectable
4n09B-5lt9A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1


(Escherichia
coli;
Homo sapiens)
PF00001
(7tm_1)
PF07361
(Cytochrom_B562)
4 LEU A1156
SER A1386
LEU A1195
LEU A1203
None
1.15A 4n09B-5n2sA:
undetectable
4n09B-5n2sA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE


(Zobellia
galactanivorans)
no annotation 4 LEU A 418
SER A 420
LEU A 512
LEU A 333
None
0.80A 4n09B-5opqA:
undetectable
4n09B-5opqA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 3


(Schizosaccharomyces
pombe)
no annotation 4 LEU A 250
LEU A 280
LEU A 265
ASN A 236
None
1.17A 4n09B-5oqrA:
undetectable
4n09B-5oqrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 3


(Schizosaccharomyces
pombe)
no annotation 4 LEU A 385
SER A 387
LEU A 408
LEU A 422
None
0.94A 4n09B-5oqrA:
undetectable
4n09B-5oqrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc1 MATURATION PROTEIN

(Escherichia
virus MS2)
PF03863
(Phage_mat-A)
4 LEU M  65
SER M 100
LEU M 104
LEU M 111
None
1.17A 4n09B-5tc1M:
undetectable
4n09B-5tc1M:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpk PROTOCADHERIN-15

(Mus musculus)
no annotation 4 LEU A 782
LEU A 766
LEU A 700
ASN A 737
None
1.25A 4n09B-5tpkA:
undetectable
4n09B-5tpkA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1


(Alicyclobacillus
acidoterrestris)
no annotation 4 LEU A 847
SER A 568
LEU A 844
LEU A 879
None
1.23A 4n09B-5u30A:
undetectable
4n09B-5u30A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium)
PF02310
(B12-binding)
4 LEU A 541
SER A 594
LEU A 486
LEU A 640
EDO  A 814 (-4.8A)
None
None
None
1.28A 4n09B-5ul4A:
5.9
4n09B-5ul4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL


(Homo sapiens)
no annotation 4 LEU A 164
SER A 226
LEU A 166
LEU A 197
None
LLP  A 280 (-3.4A)
8Z1  A 601 (-4.7A)
None
1.15A 4n09B-5v7iA:
4.6
4n09B-5v7iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x41 COBALT ABC
TRANSPORTER
ATP-BINDING PROTEIN


(Rhodobacter
capsulatus)
PF00005
(ABC_tran)
4 LEU A  37
SER A 196
LEU A 202
LEU A 239
None
0.86A 4n09B-5x41A:
undetectable
4n09B-5x41A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xox TRNA(HIS)
GUANYLYLTRANSFERASE


(Saccharomyces
cerevisiae)
PF04446
(Thg1)
PF14413
(Thg1C)
4 SER A 107
LEU A 112
LEU A 122
ASN A  60
None
1.21A 4n09B-5xoxA:
undetectable
4n09B-5xoxA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xr2 PROTEIN/NUCLEIC ACID
DEGLYCASE HCHA


(Staphylococcus
aureus)
no annotation 4 LEU A 238
SER A 219
LEU A 235
ASN A 252
None
1.18A 4n09B-5xr2A:
4.7
4n09B-5xr2A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c54 NUCLEOPROTEIN

(Zaire
ebolavirus)
no annotation 4 LEU A  74
SER A  72
LEU A 209
LEU A 203
None
0.98A 4n09B-6c54A:
undetectable
4n09B-6c54A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G


(Pyrococcus
furiosus)
no annotation 4 LEU B  66
SER B  68
LEU C  83
LEU F  16
None
1.05A 4n09B-6cfwB:
undetectable
4n09B-6cfwB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens)
no annotation 4 LEU A1267
SER A1271
LEU A1141
LEU A1293
None
1.23A 4n09B-6ez8A:
undetectable
4n09B-6ez8A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4


(Mus musculus)
no annotation 4 LEU M 106
SER M 101
LEU M  73
LEU M 235
None
3PE  M 505 ( 3.8A)
None
None
0.86A 4n09B-6g2jM:
undetectable
4n09B-6g2jM:
11.90