SIMILAR PATTERNS OF AMINO ACIDS FOR 4N09_A_ADNA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 ASP A 454
GLY A 451
ALA A 461
PHE A 326
GLY A 436
 None
 0.93A 4n09A-1b0kA:
undetectable		 4n09A-1b0kA:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		6 ASN A  20
ASP A  24
GLY A  69
ASN A  73
GLY A 315
ASP A 318
 ADN  A 375 ( 3.8A)
ADN  A 375 (-2.9A)
ADN  A 375 (-2.9A)
ADN  A 375 ( 4.9A)
ACY  A 370 (-3.1A)
ADN  A 375 ( 3.1A)
 0.46A 4n09A-1dgmA:
41.6		 4n09A-1dgmA:
34.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		7 ASP A  24
LEU A  46
GLY A  69
ASN A  73
CYH A 127
GLY A 315
ASP A 318
 ADN  A 375 (-2.9A)
None
ADN  A 375 (-2.9A)
ADN  A 375 ( 4.9A)
ADN  A 375 ( 4.2A)
ACY  A 370 (-3.1A)
ADN  A 375 ( 3.1A)
 0.62A 4n09A-1dgmA:
41.6		 4n09A-1dgmA:
34.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		5 LEU A  46
GLY A  68
ASN A  73
CYH A 127
GLY A 315
 None
ADN  A 375 ( 4.5A)
ADN  A 375 ( 4.9A)
ADN  A 375 ( 4.2A)
ACY  A 370 (-3.1A)
 1.08A 4n09A-1dgmA:
41.6		 4n09A-1dgmA:
34.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geu GLUTATHIONE
REDUCTASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 334
GLY A  15
ALA A 317
ASN A 304
GLY A 140
 None
FAD  A 451 (-3.5A)
None
None
FAD  A 451 (-3.5A)
 1.08A 4n09A-1geuA:
4.3		 4n09A-1geuA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		5 LEU A  40
GLY A   6
ALA A  39
PHE A  34
GLY A   9
 None
 1.21A 4n09A-1ghsA:
2.2		 4n09A-1ghsA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 674
GLY A 643
ALA A 673
GLY A 638
ASP A 640
 None
 1.06A 4n09A-1h17A:
undetectable		 4n09A-1h17A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7k CATALASE

(Proteus
mirabilis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 LEU A 297
GLY A 110
ASN A 127
ALA A  90
GLY A 195
 None
HEM  A 600 (-3.6A)
HEM  A 600 (-3.3A)
None
None
 1.17A 4n09A-1h7kA:
undetectable		 4n09A-1h7kA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		5 LEU A 572
CYH A 816
ALA A 549
ASN A 609
GLY A 764
 None
FMN  A1030 (-3.8A)
FMN  A1030 (-3.3A)
FMN  A1030 (-3.7A)
None
 1.12A 4n09A-1h7wA:
4.9		 4n09A-1h7wA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ken INFLUENZA VIRUS
INFECTIVITY
NEUTRALIZING
ANTIBODY (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU H   4
GLY H  32
ALA H  98
ASN H  58
GLY H  56
 None
 0.99A 4n09A-1kenH:
undetectable		 4n09A-1kenH:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrw HYPOTHETICAL
PROTEIN, HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacillus
subtilis) 		PF08282
(Hydrolase_3) 		5 ASP A   7
LEU A   3
ASN A 240
ALA A   5
GLY A  42
 PO4  A 900 ( 2.6A)
None
PO4  A 900 (-3.6A)
None
PO4  A 900 (-3.8A)
 1.18A 4n09A-1nrwA:
4.0		 4n09A-1nrwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4s ADENYLATE KINASE

(Mycobacterium
tuberculosis) 		PF00406
(ADK) 		5 ASP A  54
LEU A  45
GLY A  32
ALA A  49
GLY A  85
 None
 1.09A 4n09A-1p4sA:
2.5		 4n09A-1p4sA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 LEU A 297
GLY A 110
ASN A 127
ALA A  90
GLY A 195
 None
HEM  A 501 (-3.3A)
HEM  A 501 (-3.2A)
None
None
 1.16A 4n09A-1si8A:
undetectable		 4n09A-1si8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz6 PUTATIVE SUGAR
KINASE

(Salmonella
enterica) 		PF00294
(PfkB) 		5 ASP A  16
GLY A  31
ASN A  35
GLY A 249
ASP A 252
 AIS  A 402 (-2.5A)
AIS  A 402 (-3.8A)
AIS  A 402 (-3.9A)
AIS  A 402 ( 4.5A)
AIS  A 402 (-3.0A)
 0.46A 4n09A-1tz6A:
30.6		 4n09A-1tz6A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermus
thermophilus) 		PF00294
(PfkB) 		5 LEU A 170
GLY A  34
ASN A  38
GLY A 248
ASP A 251
 None
 0.97A 4n09A-1v19A:
30.9		 4n09A-1v19A:
28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve0 HYPOTHETICAL PROTEIN
(ST2072)

(Sulfurisphaera
tokodaii) 		PF01894
(UPF0047) 		5 ASN A  63
ALA A  65
PHE A  16
GLY A  73
ASP A  72
 None
 1.23A 4n09A-1ve0A:
undetectable		 4n09A-1ve0A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wye 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Sulfurisphaera
tokodaii) 		PF00294
(PfkB) 		5 LEU A 169
GLY A  34
ASN A  38
GLY A 253
ASP A 256
 None
 1.16A 4n09A-1wyeA:
31.2		 4n09A-1wyeA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wye 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Sulfurisphaera
tokodaii) 		PF00294
(PfkB) 		5 LEU A 169
GLY A  34
ASN A  38
GLY A 255
ASP A 256
 None
 1.22A 4n09A-1wyeA:
31.2		 4n09A-1wyeA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2b PROLINE
IMINOPEPTIDASE

(Serratia
marcescens) 		PF00561
(Abhydrolase_1) 		5 CYH A 271
ASN A 275
LEU A 249
GLY A 137
GLY A 111
 STX  A 401 ( 4.9A)
None
None
None
None
 1.20A 4n09A-1x2bA:
undetectable		 4n09A-1x2bA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 LEU A  83
GLY A 430
ALA A  84
GLY A 376
ASP A 520
 None
 1.15A 4n09A-1z8lA:
undetectable		 4n09A-1z8lA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		6 ASN A   8
ASP A  12
GLY A  37
ASN A  41
GLY A 246
ASP A 249
 None
 1.18A 4n09A-2abqA:
26.7		 4n09A-2abqA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 LEU A 171
GLY A  33
ASN A  37
GLY A 277
ASP A 280
 None
 1.05A 4n09A-2afbA:
30.8		 4n09A-2afbA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		6 ASN A   8
ASP A  12
GLY A  40
ASN A  44
GLY A 258
ASP A 261
 None
ACT  A 321 (-3.1A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
None
 1.04A 4n09A-2ajrA:
25.3		 4n09A-2ajrA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c49 SUGAR KINASE MJ0406

(Methanocaldococcus
jannaschii) 		PF00294
(PfkB) 		5 ASP A  17
GLY A  43
ASN A  47
GLY A 244
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-2.9A)
 0.66A 4n09A-2c49A:
29.7		 4n09A-2c49A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f02 TAGATOSE-6-PHOSPHATE
KINASE

(Enterococcus
faecalis) 		PF00294
(PfkB) 		6 ASN A   8
ASP A  12
GLY A  37
ASN A  41
GLY A 252
ASP A 255
 None
None
None
None
ATP  A 411 (-3.6A)
ATP  A 411 (-4.1A)
 1.10A 4n09A-2f02A:
26.5		 4n09A-2f02A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffj CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF01937
(DUF89) 		5 ASP A 194
LEU A  11
GLY A 221
ASN A 248
GLY A 245
 None
None
None
None
SO4  A 291 (-3.4A)
 1.05A 4n09A-2ffjA:
3.6		 4n09A-2ffjA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU

(Streptococcus
pneumoniae) 		PF01895
(PhoU) 		5 LEU A  31
GLY A  94
ALA A  30
PHE A 193
GLY A  20
 None
 1.18A 4n09A-2i0mA:
undetectable		 4n09A-2i0mA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i6b ADENOSINE KINASE

(Homo sapiens) 		PF00294
(PfkB) 		8 ASN A  14
ASP A  18
GLY A  64
ASN A  68
CYH A 123
ALA A 136
GLY A 297
ASP A 300
 89I  A 500 (-4.0A)
None
89I  A 500 (-3.5A)
None
None
89I  A 500 (-3.4A)
None
None
 0.82A 4n09A-2i6bA:
42.8		 4n09A-2i6bA:
40.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i6b ADENOSINE KINASE

(Homo sapiens) 		PF00294
(PfkB) 		6 ASN A  14
GLY A  64
ASN A  68
PHE A 170
GLY A 297
ASP A 300
 89I  A 500 (-4.0A)
89I  A 500 (-3.5A)
None
89I  A 500 (-3.8A)
None
None
 0.52A 4n09A-2i6bA:
42.8		 4n09A-2i6bA:
40.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i6b ADENOSINE KINASE

(Homo sapiens) 		PF00294
(PfkB) 		5 ASP A  18
LEU A  40
CYH A 123
ALA A 136
ASN A  68
 None
89I  A 500 ( 4.8A)
None
89I  A 500 (-3.4A)
None
 1.20A 4n09A-2i6bA:
42.8		 4n09A-2i6bA:
40.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i6b ADENOSINE KINASE

(Homo sapiens) 		PF00294
(PfkB) 		8 ASP A  18
LEU A  40
GLY A  64
ASN A  68
CYH A 123
ALA A 136
GLY A 297
ASP A 300
 None
89I  A 500 ( 4.8A)
89I  A 500 (-3.5A)
None
None
89I  A 500 (-3.4A)
None
None
 0.77A 4n09A-2i6bA:
42.8		 4n09A-2i6bA:
40.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 LEU A 297
GLY A 110
ASN A 127
ALA A  90
GLY A 195
 None
HEM  A 486 (-3.6A)
HEM  A 486 (-3.4A)
None
None
 1.17A 4n09A-2isaA:
undetectable		 4n09A-2isaA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		6 ASN A   8
ASP A  12
GLY A  37
ASN A  41
GLY A 246
ASP A 249
 None
 1.23A 4n09A-2jg5A:
26.0		 4n09A-2jg5A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 ASP A 273
LEU A 162
GLY A 152
ASN A 302
ALA A 159
 PLP  A1494 (-2.7A)
None
PLP  A1494 (-3.5A)
PLP  A1494 (-3.5A)
None
 1.20A 4n09A-2jisA:
3.9		 4n09A-2jisA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		5 ASP A  22
GLY A  44
ASN A  48
GLY A 269
ASP A 272
 None
None
None
None
PGE  A 332 (-3.6A)
 0.51A 4n09A-2qcvA:
31.1		 4n09A-2qcvA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1c ACYL-COENZYME

(Penicillium
chrysogenum) 		PF03417
(AAT) 		5 ASP A 264
LEU A 275
ASN A 246
GLY A 102
ASP A 121
 None
 1.09A 4n09A-2x1cA:
undetectable		 4n09A-2x1cA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		5 ASN A 441
GLY A 403
ASN A 405
GLY A 382
ASP A 400
 None
CA  A 621 ( 4.7A)
CA  A 621 (-2.8A)
CA  A 621 ( 4.8A)
CA  A 621 (-2.3A)
 0.99A 4n09A-2z8zA:
undetectable		 4n09A-2z8zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv6 METAL-DEPENDENT
HYDROLASE

(Vibrio cholerae) 		PF13483
(Lactamase_B_3) 		5 LEU A 114
ALA A 112
ASN A  55
GLY A  54
ASP A 174
 None
 1.18A 4n09A-3bv6A:
undetectable		 4n09A-3bv6A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewm UNCHARACTERIZED
SUGAR KINASE PH1459

(Pyrococcus
horikoshii) 		PF00294
(PfkB) 		6 ASP A  13
LEU A 167
GLY A  34
ASN A  38
GLY A 244
ASP A 247
 None
 1.08A 4n09A-3ewmA:
29.8		 4n09A-3ewmA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6m 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF02542
(YgbB) 		5 LEU A  50
GLY A  23
ALA A  46
GLY A  39
ASP A  38
 None
 1.15A 4n09A-3f6mA:
undetectable		 4n09A-3f6mA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fle SE_1780 PROTEIN

(Staphylococcus
epidermidis) 		PF06028
(DUF915) 		5 ASN A 118
GLY A 146
ASN A 147
PHE A 115
GLY A 174
 None
 1.22A 4n09A-3fleA:
3.6		 4n09A-3fleA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 ASP A  25
GLY A  51
ASN A  55
GLY A 239
ASP A 242
 RIB  A 305 (-2.8A)
RIB  A 305 (-3.1A)
RIB  A 305 (-3.2A)
RIB  A 305 ( 4.5A)
RIB  A 305 (-2.9A)
 0.45A 4n09A-3go7A:
28.9		 4n09A-3go7A:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj6 FRUCTOKINASE

(Halothermothrix
orenii) 		PF00294
(PfkB) 		5 ASP A  33
LEU A 188
GLY A  55
ASN A  59
ASP A 275
 None
 0.88A 4n09A-3hj6A:
28.1		 4n09A-3hj6A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwu PUTATIVE DNA-BINDING
PROTEIN

(Cupriavidus
pinatubonensis) 		PF03479
(DUF296) 		5 GLY A  71
ASN A 102
CYH A 144
PHE A  69
GLY A 120
 None
 1.23A 4n09A-3hwuA:
undetectable		 4n09A-3hwuA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3y CARBOHYDRATE KINASE

(Klebsiella
pneumoniae) 		PF00294
(PfkB) 		5 ASP A  12
GLY A  38
ASN A  42
GLY A 229
ASP A 232
 None
 0.83A 4n09A-3i3yA:
26.4		 4n09A-3i3yA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4f 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Bacillus
thuringiensis) 		PF13561
(adh_short_C2) 		5 ASP A 255
LEU A 240
GLY A 253
ALA A 237
GLY A 223
 None
 1.13A 4n09A-3i4fA:
7.8		 4n09A-3i4fA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		5 GLY 3 294
CYH 3 263
ASN 3 225
GLY 3 224
ASP 3 292
 SF4  3 786 (-3.4A)
SF4  3 786 (-2.2A)
None
None
None
 1.20A 4n09A-3i9v3:
3.8		 4n09A-3i9v3:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in1 UNCHARACTERIZED
SUGAR KINASE YDJH

(Escherichia
coli) 		PF00294
(PfkB) 		5 ASP A  15
GLY A  42
ASN A  46
GLY A 257
ASP A 260
 None
None
None
NA  A 411 ( 4.9A)
None
 0.72A 4n09A-3in1A:
30.9		 4n09A-3in1A:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isl PURINE CATABOLISM
PROTEIN PUCG

(Bacillus
subtilis) 		PF00266
(Aminotran_5) 		5 CYH A 328
GLY A 152
CYH A 321
PHE A 316
GLY A  97
 None
 0.89A 4n09A-3islA:
5.5		 4n09A-3islA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ASP A 245
LEU A 166
GLY A 243
ALA A 209
GLY A 263
 None
 1.13A 4n09A-3iveA:
undetectable		 4n09A-3iveA:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE

(Anopheles
gambiae) 		PF00294
(PfkB) 		10 ASN A  14
ASP A  18
LEU A  40
GLY A  64
ASN A  68
CYH A 122
ALA A 135
PHE A 168
GLY A 297
ASP A 300
 B4P  A 349 ( 4.0A)
B4P  A 349 (-2.8A)
None
B4P  A 349 (-3.5A)
B4P  A 349 (-3.6A)
B4P  A 349 (-3.6A)
B4P  A 349 (-3.4A)
B4P  A 349 (-3.4A)
B4P  A 349 (-2.9A)
B4P  A 349 (-3.4A)
 0.46A 4n09A-3looA:
48.1		 4n09A-3looA:
36.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE

(Anopheles
gambiae) 		PF00294
(PfkB) 		10 ASN A  14
LEU A  40
GLY A  64
ASN A  68
CYH A 122
ALA A 135
PHE A 168
ASN A 296
GLY A 297
ASP A 300
 B4P  A 349 ( 4.0A)
None
B4P  A 349 (-3.5A)
B4P  A 349 (-3.6A)
B4P  A 349 (-3.6A)
B4P  A 349 (-3.4A)
B4P  A 349 (-3.4A)
B4P  A 349 (-3.6A)
B4P  A 349 (-2.9A)
B4P  A 349 (-3.4A)
 0.78A 4n09A-3looA:
48.1		 4n09A-3looA:
36.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE

(Anopheles
gambiae) 		PF00294
(PfkB) 		6 GLY A  63
ASN A  68
CYH A 122
ALA A 135
GLY A 297
ASP A 300
 B4P  A 349 ( 3.8A)
B4P  A 349 (-3.6A)
B4P  A 349 (-3.6A)
B4P  A 349 (-3.4A)
B4P  A 349 (-2.9A)
B4P  A 349 (-3.4A)
 1.17A 4n09A-3looA:
48.1		 4n09A-3looA:
36.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oib ACYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 CYH A 113
LEU A  62
GLY A  73
ALA A  66
PHE A 111
 None
IOD  A 502 ( 4.4A)
None
None
None
 1.20A 4n09A-3oibA:
undetectable		 4n09A-3oibA:
22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3otx ADENOSINE KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00294
(PfkB) 		5 ASP A  17
LEU A  39
CYH A 123
ALA A 136
ASN A  67
 AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.7A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
 1.21A 4n09A-3otxA:
58.6		 4n09A-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3otx ADENOSINE KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00294
(PfkB) 		6 ASP A  17
LEU A  39
CYH A 123
ALA A 136
PHE A 169
GLY A 296
 AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.7A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.2A)
 0.71A 4n09A-3otxA:
58.6		 4n09A-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3otx ADENOSINE KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00294
(PfkB) 		10 CYH A  12
ASN A  13
ASP A  17
LEU A  39
GLY A  63
ASN A  67
CYH A 123
ALA A 136
PHE A 169
ASP A 299
 AP5  A 346 (-3.6A)
AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.7A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 ( 3.2A)
 0.18A 4n09A-3otxA:
58.6		 4n09A-3otxA:
99.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3otx ADENOSINE KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00294
(PfkB) 		7 CYH A  12
ASN A  13
LEU A  39
ASN A  67
PHE A 169
GLY A 298
ASP A 299
 AP5  A 346 (-3.6A)
AP5  A 346 (-4.1A)
None
AP5  A 346 (-3.4A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.2A)
AP5  A 346 ( 3.2A)
 1.15A 4n09A-3otxA:
58.6		 4n09A-3otxA:
99.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY

(Corynebacterium
glutamicum) 		PF00294
(PfkB) 		5 ASP A  19
GLY A  41
ASN A  45
GLY A 261
ASP A 264
 None
 0.54A 4n09A-3pl2A:
31.0		 4n09A-3pl2A:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		6 ASN A   8
ASP A  12
GLY A  38
CYH A  92
GLY A 248
ASP A 251
 None
 0.96A 4n09A-3q1yA:
26.1		 4n09A-3q1yA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3u LIGNIN PEROXIDASE

(Trametopsis
cervina) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 ASN A 134
LEU A  99
GLY A 106
ALA A  98
ASP A  48
 None
None
None
None
CA  A 340 (-3.3A)
 1.04A 4n09A-3q3uA:
undetectable		 4n09A-3q3uA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stt METHYLKETONE
SYNTHASE I

(Solanum
habrochaites) 		PF12697
(Abhydrolase_6) 		5 LEU A  83
GLY A 203
ALA A 107
ASN A 230
GLY A 116
 None
 1.12A 4n09A-3sttA:
5.0		 4n09A-3sttA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t32 AMINOTRANSFERASE,
CLASS I/II

(Bacillus
anthracis) 		PF00155
(Aminotran_1_2) 		5 ASN A 294
LEU A 375
CYH A 299
ALA A 298
GLY A 170
 None
 1.19A 4n09A-3t32A:
undetectable		 4n09A-3t32A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		7 ASN A  11
ASP A  15
LEU A  37
GLY A  59
ASN A  63
GLY A 275
ASP A 278
 ADN  A 353 (-3.7A)
ADN  A 353 (-2.8A)
None
ADN  A 353 (-3.2A)
ADN  A 353 (-3.4A)
ADN  A 353 (-3.7A)
ADN  A 353 (-3.3A)
 0.52A 4n09A-3uboA:
39.6		 4n09A-3uboA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		5 LEU A1220
GLY A1252
ASN A1251
ALA A1219
GLY A1150
 None
 1.21A 4n09A-3ummA:
2.1		 4n09A-3ummA:
14.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vas PUTATIVE ADENOSINE
KINASE

(Schistosoma
mansoni) 		PF00294
(PfkB) 		9 ASN A  14
ASP A  18
LEU A  40
GLY A  64
ASN A  68
PHE A 169
ASN A 298
GLY A 299
ASP A 302
 ADN  A 401 ( 4.0A)
ADN  A 401 (-2.7A)
None
ADN  A 401 (-3.7A)
ADN  A 401 (-3.7A)
ADN  A 401 (-3.7A)
ADN  A 401 (-3.7A)
ADN  A 401 ( 3.8A)
ADN  A 401 (-2.9A)
 0.43A 4n09A-3vasA:
47.3		 4n09A-3vasA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vas PUTATIVE ADENOSINE
KINASE

(Schistosoma
mansoni) 		PF00294
(PfkB) 		6 ASP A  18
LEU A 138
PHE A 169
ASN A 298
GLY A 299
ASP A 302
 ADN  A 401 (-2.7A)
ADN  A 401 (-4.9A)
ADN  A 401 (-3.7A)
ADN  A 401 (-3.7A)
ADN  A 401 ( 3.8A)
ADN  A 401 (-2.9A)
 1.39A 4n09A-3vasA:
47.3		 4n09A-3vasA:
30.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp5 CDBFV

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		5 ASN A 207
GLY A 209
ASN A  54
ASN A  38
GLY A  36
 None
 1.10A 4n09A-3wp5A:
undetectable		 4n09A-3wp5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		5 ASN A  76
LEU A 151
GLY A  79
ASN A 225
GLY A 226
 None
 1.13A 4n09A-3zs6A:
undetectable		 4n09A-3zs6A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4beq ALANINE RACEMASE 2

(Vibrio cholerae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 LEU A 256
GLY A 169
ASN A 167
PHE A 220
GLY A 175
 None
 1.16A 4n09A-4beqA:
undetectable		 4n09A-4beqA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli) 		PF00294
(PfkB) 		7 ASN A   9
ASP A  13
LEU A  35
GLY A  57
ASN A  61
GLY A 273
ASP A 276
 ADN  A 500 (-3.8A)
ADN  A 500 (-2.7A)
None
ADN  A 500 (-3.7A)
ADN  A 500 (-3.5A)
ADN  A 500 (-3.9A)
ADN  A 500 (-2.8A)
 0.45A 4n09A-4e3aA:
41.0		 4n09A-4e3aA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli) 		PF00294
(PfkB) 		5 ASP A  13
LEU A 129
ASN A  61
GLY A 273
ASP A 276
 ADN  A 500 (-2.7A)
None
ADN  A 500 (-3.5A)
ADN  A 500 (-3.9A)
ADN  A 500 (-2.8A)
 1.17A 4n09A-4e3aA:
41.0		 4n09A-4e3aA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e84 D-BETA-D-HEPTOSE
7-PHOSPHATE KINASE

(Burkholderia
cenocepacia) 		PF00294
(PfkB) 		5 ASP A  29
GLY A  59
ASN A  62
GLY A 267
ASP A 270
 M7B  A 502 (-2.9A)
M7B  A 502 (-3.6A)
None
M7B  A 502 (-3.7A)
M7B  A 502 (-3.1A)
 1.16A 4n09A-4e84A:
27.1		 4n09A-4e84A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm6 PFKB FAMILY
CARBOHYDRATE KINASE

(Listeria grayi) 		PF00294
(PfkB) 		5 LEU A 172
GLY A  34
ASN A  38
GLY A 267
ASP A 270
 None
GOL  A 401 (-3.7A)
GOL  A 401 (-4.4A)
GOL  A 401 ( 4.5A)
GOL  A 401 (-3.0A)
 0.95A 4n09A-4gm6A:
29.2		 4n09A-4gm6A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		5 GLY A 426
ALA A 437
PHE A 443
ASN A 249
GLY A 247
 None
 1.21A 4n09A-4knaA:
3.5		 4n09A-4knaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Jonesia
denitrificans) 		PF16262
(DUF4916) 		5 LEU A 178
GLY A 186
ALA A 181
GLY A  51
ASP A  52
 None
 1.12A 4n09A-4ktbA:
undetectable		 4n09A-4ktbA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B

(Danio rerio;
Homo sapiens) 		PF00071
(Ras)
PF08337
(Plexin_cytopl) 		5 ASN A1005
LEU A1000
PHE E  64
GLY A1025
ASP A1024
 None
 1.08A 4n09A-4m8nA:
undetectable		 4n09A-4m8nA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 ASP A 257
ALA A 146
PHE A 116
GLY A  47
ASP A  12
 HO4  A 401 (-3.3A)
HO4  A 401 (-4.3A)
HO4  A 401 (-3.6A)
HO4  A 401 (-3.5A)
HO4  A 401 (-2.4A)
 1.05A 4n09A-4pvvA:
28.2		 4n09A-4pvvA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tl9 CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Synechococcus
elongatus) 		PF06745
(ATPase) 		5 ASN A 245
LEU A  54
GLY A  27
GLY A  35
ASP A  29
 None
AGS  A 303 (-4.2A)
None
None
None
 1.12A 4n09A-4tl9A:
3.0		 4n09A-4tl9A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 LEU A 140
GLY A 162
ALA A 139
ASN A 169
GLY A 166
 None
 0.91A 4n09A-4uozA:
4.0		 4n09A-4uozA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB

(Brucella
abortus) 		PF00294
(PfkB) 		5 ASP A  11
GLY A  30
ASN A  34
GLY A 246
ASP A 249
 None
None
None
ANP  A 401 (-3.3A)
ANP  A 401 ( 4.3A)
 0.50A 4n09A-4wjmA:
29.9		 4n09A-4wjmA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB

(Brucella
abortus) 		PF00294
(PfkB) 		5 GLY A  30
ASN A  34
ALA A  85
GLY A 246
ASP A 249
 None
None
None
ANP  A 401 (-3.3A)
ANP  A 401 ( 4.3A)
 0.98A 4n09A-4wjmA:
29.9		 4n09A-4wjmA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB

(Brucella
abortus) 		PF00294
(PfkB) 		5 LEU A  42
ASN A 157
ALA A  38
GLY A 126
ASP A 155
 None
ANP  A 401 (-3.6A)
None
None
None
 1.11A 4n09A-4wjmA:
29.9		 4n09A-4wjmA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		5 LEU A1396
ASN A1370
ALA A1400
ASN A 377
GLY A 376
 None
 1.21A 4n09A-4yknA:
undetectable		 4n09A-4yknA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomyces
pombe) 		PF00483
(NTP_transferase) 		5 LEU E  64
CYH E 148
ALA E  63
ASN E  49
ASP E 124
 None
 1.06A 4n09A-5b04E:
undetectable		 4n09A-5b04E:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c41 RIBOKINASE

(Homo sapiens) 		PF00294
(PfkB) 		5 ASP A  27
GLY A  53
ASN A  57
GLY A 266
ASP A 269
 None
None
None
ACP  A 401 ( 4.1A)
NA  A 403 ( 4.7A)
 0.46A 4n09A-5c41A:
29.7		 4n09A-5c41A:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwv NUCLEOPORIN NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 ASN A1527
LEU A1586
CYH A1520
GLY A1472
ASP A1473
 None
 1.21A 4n09A-5cwvA:
undetectable		 4n09A-5cwvA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		5 GLY A 317
ASN A 301
PHE A 656
ASN A 558
GLY A 590
 None
 1.17A 4n09A-5dkxA:
undetectable		 4n09A-5dkxA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 198
GLY A 223
ASN A 233
ALA A 195
GLY A 231
 None
 1.13A 4n09A-5e7qA:
2.7		 4n09A-5e7qA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey7 FRUCTOKINASE

(Vibrio cholerae) 		PF00294
(PfkB) 		5 ASP A  30
GLY A  45
ASN A  49
GLY A 263
ASP A 266
 None
 0.72A 4n09A-5ey7A:
31.2		 4n09A-5ey7A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i73 8B6 ANTIBODY, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU B 102
GLY B  68
ASN B  69
ALA B  87
GLY B  76
 None
 1.20A 4n09A-5i73B:
undetectable		 4n09A-5i73B:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwr CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Thermosynechococcus
elongatus) 		PF06745
(ATPase) 		5 ASN A 245
LEU A  55
GLY A  28
GLY A  36
ASP A  30
 None
 1.05A 4n09A-5jwrA:
4.6		 4n09A-5jwrA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 5 ASP A  37
GLY A 115
ALA A 204
GLY A 440
ASP A 443
 GLC  A 503 (-2.7A)
GLC  A 503 (-3.7A)
None
GLC  A 503 ( 4.1A)
GLC  A 503 (-2.6A)
 0.96A 4n09A-5o0jA:
24.1		 4n09A-5o0jA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 5 ASP A  37
LEU A  93
GLY A 115
ALA A 204
GLY A 440
 GLC  A 503 (-2.7A)
None
GLC  A 503 (-3.7A)
None
GLC  A 503 ( 4.1A)
 1.15A 4n09A-5o0jA:
24.1		 4n09A-5o0jA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria) 		no annotation 5 LEU A 292
GLY A 307
PHE A 310
GLY A 248
ASP A 247
 None
 1.16A 4n09A-5o3wA:
undetectable		 4n09A-5o3wA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 5 ASP A  28
GLY A 107
ALA A 201
GLY A 439
ASP A 442
 GLC  A 501 (-2.7A)
GLC  A 501 (-3.7A)
None
PO4  A 504 (-3.1A)
GLC  A 501 ( 2.6A)
 0.81A 4n09A-5od2A:
22.4		 4n09A-5od2A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odp -

(-) 		no annotation 5 LEU A  62
CYH A  30
ALA A  58
PHE A  78
GLY A  15
 None
 1.15A 4n09A-5odpA:
undetectable		 4n09A-5odpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cw5 RIBOKINASE

(Cryptococcus
neoformans) 		no annotation 5 ASP A  16
GLY A  42
ASN A  46
GLY A 270
ASP A 273
 GOL  A 400 (-2.8A)
GOL  A 400 (-3.3A)
GOL  A 400 (-3.3A)
None
None
 0.56A 4n09A-6cw5A:
31.9		 4n09A-6cw5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eua ANGIOPOIETIN-RELATED
PROTEIN 3

(Homo sapiens) 		no annotation 5 ASN A 301
ASN A 296
PHE A 306
ASN A 412
GLY A 415
 None
 1.19A 4n09A-6euaA:
undetectable		 4n09A-6euaA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1j -

(-) 		no annotation 5 ASN A 267
LEU A 324
GLY A 269
ALA A 325
GLY A  38
 None
 1.13A 4n09A-6f1jA:
undetectable		 4n09A-6f1jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8o ICE INHIBITOR

(Cowpox virus) 		PF00079
(Serpin) 		4 LEU A  27
SER A  22
LEU A 246
LEU A  30
 None
 1.07A 4n09A-1c8oA:
undetectable		 4n09A-1c8oA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8u ACYL-COA
THIOESTERASE II

(Escherichia
coli) 		PF13622
(4HBT_3) 		4 LEU A 198
SER A 203
LEU A  44
LEU A   8
 None
 1.10A 4n09A-1c8uA:
undetectable		 4n09A-1c8uA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9e PROTOHEME FERROLYASE

(Bacillus
subtilis) 		PF00762
(Ferrochelatase) 		4 LEU A   8
SER A 110
LEU A 308
LEU A  67
 None
 0.95A 4n09A-1c9eA:
2.4		 4n09A-1c9eA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbr PROTEIN (HEMOGLOBIN
D)

(Gallus gallus) 		PF00042
(Globin) 		4 LEU A  76
SER A 133
LEU A  66
LEU A   2
 None
HEM  A 142 ( 4.4A)
None
None
 1.02A 4n09A-1hbrA:
undetectable		 4n09A-1hbrA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2w BETA-LACTAMASE

(Bacillus
licheniformis) 		PF13354
(Beta-lactamase2) 		4 LEU A  81
SER A  87
LEU A 119
LEU A 206
 None
 0.79A 4n09A-1i2wA:
undetectable		 4n09A-1i2wA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jg5 GTP CYCLOHYDROLASE I
FEEDBACK REGULATORY
PROTEIN

(Rattus
norvegicus) 		PF06399
(GFRP) 		4 LEU A  80
SER A  68
LEU A   4
LEU A  56
 None
 1.05A 4n09A-1jg5A:
undetectable		 4n09A-1jg5A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I

(Escherichia
coli) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 LEU A  25
SER A  23
LEU A  33
LEU A 167
 None
 1.06A 4n09A-1k0gA:
undetectable		 4n09A-1k0gA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A

(Thermobifida
fusca) 		PF00079
(Serpin) 		4 LEU A  43
SER A  38
LEU A 267
LEU A  46
 None
 1.05A 4n09A-1mtpA:
undetectable		 4n09A-1mtpA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 LEU A 531
SER A 479
LEU A 474
LEU A 399
 None
 1.03A 4n09A-1qhgA:
undetectable		 4n09A-1qhgA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
no annotation 		4 LEU C 531
SER C 479
LEU C 474
LEU B 399
 None
 1.07A 4n09A-1qhhC:
undetectable		 4n09A-1qhhC:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgj CITRATE LYASE, BETA
SUBUNIT

(Deinococcus
radiodurans) 		PF03328
(HpcH_HpaI) 		4 LEU A 190
SER A  10
LEU A   7
LEU A 125
 None
 0.94A 4n09A-1sgjA:
2.6		 4n09A-1sgjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		4 LEU A 395
SER A 371
LEU A 407
LEU A  15
 None
 1.00A 4n09A-1venA:
2.2		 4n09A-1venA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 LEU A 338
SER A 406
LEU A 333
LEU A 347
 None
 1.03A 4n09A-1x9nA:
undetectable		 4n09A-1x9nA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Borreliella
burgdorferi) 		PF02127
(Peptidase_M18) 		4 LEU A 135
SER A 132
LEU A 193
LEU A 101
 None
 1.04A 4n09A-1y7eA:
2.2		 4n09A-1y7eA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 4 LEU A 246
SER A 242
LEU A 271
LEU A 249
 None
 1.03A 4n09A-1yrgA:
2.2		 4n09A-1yrgA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx1 HYPOTHETICAL PROTEIN
PA2260

(Pseudomonas
aeruginosa) 		PF01261
(AP_endonuc_2) 		4 LEU A  29
SER A  25
LEU A  10
LEU A 236
 None
 1.08A 4n09A-1yx1A:
undetectable		 4n09A-1yx1A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1

(Pseudomonas
aeruginosa) 		PF04166
(PdxA) 		4 LEU A1317
SER A1293
LEU A1019
LEU A1032
 None
 1.06A 4n09A-1yxoA:
undetectable		 4n09A-1yxoA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7h HEMOGLOBIN ALPHA
CHAIN

(Cerdocyon thous) 		PF00042
(Globin) 		4 LEU A  76
SER A 133
LEU A  66
LEU A   2
 None
HEM  A 200 ( 4.8A)
HEM  A 200 ( 4.6A)
None
 0.91A 4n09A-2b7hA:
undetectable		 4n09A-2b7hA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dd7 GREEN FLUORESCENT
PROTEIN

(Chiridius
poppei) 		PF01353
(GFP) 		4 LEU A  43
SER A  46
LEU A  14
LEU A  21
 None
 1.04A 4n09A-2dd7A:
undetectable		 4n09A-2dd7A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ett SORTING NEXIN-22

(Homo sapiens) 		PF00787
(PX) 		4 LEU A  58
SER A  53
LEU A  91
LEU A 109
 None
 0.99A 4n09A-2ettA:
undetectable		 4n09A-2ettA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 806
SER A 784
LEU A 580
LEU A 810
 None
 1.11A 4n09A-2faqA:
undetectable		 4n09A-2faqA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fup HYPOTHETICAL PROTEIN
PA3352

(Pseudomonas
aeruginosa) 		PF05130
(FlgN) 		4 LEU A 126
SER A 124
LEU A 109
LEU A  21
 None
 1.07A 4n09A-2fupA:
undetectable		 4n09A-2fupA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6y GREEN FLUORESCENT
PROTEIN 2

(Pontellina
plumata) 		PF01353
(GFP) 		4 LEU A  45
SER A  48
LEU A  14
LEU A  21
 None
 1.06A 4n09A-2g6yA:
undetectable		 4n09A-2g6yA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3m PROLYL-TRNA
SYNTHETASE

(Enterococcus
faecalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		4 LEU A 149
SER A  41
LEU A  27
LEU A 449
 None
 0.95A 4n09A-2j3mA:
undetectable		 4n09A-2j3mA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqq PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00027
(cNMP_binding) 		4 LEU A 101
SER A  27
LEU A  47
LEU A  37
 None
 1.11A 4n09A-2pqqA:
undetectable		 4n09A-2pqqA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 127
SER A 122
LEU A 141
LEU A 137
 None
 1.11A 4n09A-2qyvA:
2.4		 4n09A-2qyvA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkc HEMAGGLUTININ

(Measles
morbillivirus) 		PF00423
(HN) 		4 LEU A 299
SER A 414
LEU A 339
LEU A 321
 None
 1.12A 4n09A-2rkcA:
undetectable		 4n09A-2rkcA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyo HYPOTHETICAL PROTEIN
ML2640

(Mycobacterium
leprae) 		PF04072
(LCM) 		4 LEU A 188
SER A 111
LEU A 184
LEU A 200
 None
 1.06A 4n09A-2uyoA:
undetectable		 4n09A-2uyoA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE

(Nocardia
farcinica) 		no annotation 4 LEU A 226
SER A 224
LEU A 241
LEU A  25
 None
 1.10A 4n09A-2xecA:
3.2		 4n09A-2xecA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zet MELANOPHILIN

(Mus musculus) 		PF02318
(FYVE_2) 		4 LEU C  59
SER C  54
LEU C  86
LEU C  68
 None
 1.10A 4n09A-2zetC:
undetectable		 4n09A-2zetC:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		4 LEU A 559
SER A 557
LEU A 539
LEU A 466
 None
 1.06A 4n09A-3a6pA:
undetectable		 4n09A-3a6pA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alx HEMAGGLUTININ,LINKER
,CDW150

(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		PF00423
(HN)
PF06214
(SLAM) 		4 LEU A 299
SER A 414
LEU A 339
LEU A 321
 None
 1.10A 4n09A-3alxA:
undetectable		 4n09A-3alxA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0s UNCHARACTERIZED
PROTEIN

(Chlorobaculum
tepidum) 		PF05235
(CHAD) 		4 LEU A 443
SER A 503
LEU A 392
LEU A 447
 None
 1.04A 4n09A-3e0sA:
undetectable		 4n09A-3e0sA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ew7 LMO0794 PROTEIN

(Listeria
monocytogenes) 		PF13460
(NAD_binding_10) 		4 LEU A  90
SER A  88
LEU A  83
LEU A  59
 None
 1.12A 4n09A-3ew7A:
7.2		 4n09A-3ew7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3x TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY, PUTATIVE

(Sulfolobus
solfataricus) 		PF13463
(HTH_27) 		4 LEU A  43
SER A  41
LEU A  29
LEU A  74
 None
 1.09A 4n09A-3f3xA:
undetectable		 4n09A-3f3xA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g01 GRANZYME C

(Mus musculus) 		PF00089
(Trypsin) 		4 LEU A 130
SER A 239
LEU A 235
LEU A  61
 None
 1.11A 4n09A-3g01A:
undetectable		 4n09A-3g01A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hg7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Aeromonas
salmonicida) 		PF02826
(2-Hacid_dh_C) 		4 LEU A  10
SER A  12
LEU A  51
LEU A  22
 None
 1.07A 4n09A-3hg7A:
undetectable		 4n09A-3hg7A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase) 		4 LEU A 115
SER A 176
LEU A 171
LEU A 112
 None
 1.09A 4n09A-3j09A:
3.6		 4n09A-3j09A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 U2 SMALL NUCLEAR
RIBONUCLEOPROTEIN A'

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		4 LEU j  92
SER j 118
LEU j  69
LEU j  56
 None
 1.05A 4n09A-3jb9j:
undetectable		 4n09A-3jb9j:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrp FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 LEU A 271
SER A 261
LEU A 280
LEU A 248
 None
 1.10A 4n09A-3jrpA:
undetectable		 4n09A-3jrpA:
23.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE

(Anopheles
gambiae) 		PF00294
(PfkB) 		4 LEU A  16
SER A  65
LEU A 133
LEU A 137
 B4P  A 349 (-4.7A)
CL  A 351 ( 4.6A)
B4P  A 349 (-4.5A)
None
 0.44A 4n09A-3looA:
48.1		 4n09A-3looA:
36.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhe UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A 502
SER A 442
LEU A 593
LEU A 455
 None
 1.01A 4n09A-3nheA:
undetectable		 4n09A-3nheA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on5 BH1974 PROTEIN

(Bacillus
halodurans) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		4 LEU A 195
SER A 313
LEU A 275
LEU A 183
 None
 1.01A 4n09A-3on5A:
5.1		 4n09A-3on5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oru DUF1989 FAMILY
PROTEIN

(Ruegeria sp.
TM1040) 		PF09347
(DUF1989) 		4 LEU A  84
SER A 101
LEU A 108
LEU A  88
 None
 1.10A 4n09A-3oruA:
undetectable		 4n09A-3oruA:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3otx ADENOSINE KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00294
(PfkB) 		4 LEU A  15
SER A  64
LEU A 134
LEU A 138
 AP5  A 346 (-4.4A)
NA  A 347 (-4.8A)
AP5  A 346 ( 4.4A)
None
 0.22A 4n09A-3otxA:
58.6		 4n09A-3otxA:
99.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlf MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALG

(Escherichia
coli) 		PF00528
(BPD_transp_1) 		4 LEU G 236
SER G 234
LEU G 137
LEU G 156
 None
 1.07A 4n09A-3rlfG:
undetectable		 4n09A-3rlfG:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuz PROTEIN SHQ1

(Saccharomyces
cerevisiae) 		PF04925
(SHQ1) 		4 LEU A 306
SER A 304
LEU A 450
LEU A 410
 None
 1.01A 4n09A-3zuzA:
undetectable		 4n09A-3zuzA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 LEU A 464
SER A 444
LEU A 480
LEU A 472
 None
 0.98A 4n09A-4cyjA:
undetectable		 4n09A-4cyjA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv MTERF
DOMAIN-CONTAINING
PROTEIN 2
PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F)
PF02536
(mTERF) 		4 LEU A  68
SER A  66
LEU B 271
LEU A  45
 None
 1.11A 4n09A-4fzvA:
3.4		 4n09A-4fzvA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		4 LEU M 698
SER M 582
LEU M 577
LEU M 639
 None
 1.11A 4n09A-4gq2M:
undetectable		 4n09A-4gq2M:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 884
SER A 810
LEU A 670
LEU A 874
 None
 1.06A 4n09A-4htzA:
undetectable		 4n09A-4htzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 LEU A 347
SER A 336
LEU A 175
LEU A 345
 None
 1.04A 4n09A-4jzaA:
undetectable		 4n09A-4jzaA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k37 ANAEROBIC
SULFATASE-MATURATING
ENZYME

(Clostridium
perfringens) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12) 		4 LEU A 112
SER A 107
LEU A 152
LEU A  97
 None
 1.04A 4n09A-4k37A:
2.8		 4n09A-4k37A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdr AP-4 COMPLEX SUBUNIT
MU-1

(Homo sapiens) 		PF00928
(Adap_comp_sub) 		4 LEU A 315
SER A 301
LEU A 377
LEU A 334
 None
 1.12A 4n09A-4mdrA:
undetectable		 4n09A-4mdrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhp GLUTAMINYL CYCLASE,
PUTATIVE

(Ixodes
scapularis) 		PF04389
(Peptidase_M28) 		4 LEU A 163
SER A 158
LEU A  88
LEU A 175
 None
 1.07A 4n09A-4mhpA:
undetectable		 4n09A-4mhpA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		4 LEU A 198
SER A 190
LEU A 195
LEU A 206
 None
 1.03A 4n09A-4pspA:
3.6		 4n09A-4pspA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxh PEPTIDE SYNTHETASE

(Streptomyces
sp. Acta 2897) 		PF00550
(PP-binding) 		4 LEU B  60
SER B  50
LEU B  62
LEU B  74
 None
 1.08A 4n09A-4pxhB:
undetectable		 4n09A-4pxhB:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4j ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU A 126
SER A 300
LEU A   4
LEU A 130
 None
 0.87A 4n09A-4q4jA:
undetectable		 4n09A-4q4jA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6t GLYCOSYL HYDROLASE,
FAMILY 18

(Pseudomonas
protegens) 		PF00704
(Glyco_hydro_18) 		4 LEU A 362
SER A 347
LEU A  56
LEU A 366
 None
 1.09A 4n09A-4q6tA:
undetectable		 4n09A-4q6tA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdn FLAGELLAR PROTEIN
FLGJ [PEPTIDOGLYCAN
HYDROLASE]

(Thermotoga
maritima) 		PF01832
(Glucosaminidase) 		4 LEU A  27
SER A  12
LEU A  46
LEU A  89
 None
 1.05A 4n09A-4qdnA:
undetectable		 4n09A-4qdnA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 152
SER A 148
LEU A 158
LEU A 128
 None
 1.11A 4n09A-4qxeA:
undetectable		 4n09A-4qxeA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxf LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU A 152
SER A 148
LEU A 158
LEU A 128
 None
 1.08A 4n09A-4qxfA:
undetectable		 4n09A-4qxfA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rz2 SITE-DETERMINING
PROTEIN

(Geobacillus
thermodenitrificans) 		PF10609
(ParA) 		4 LEU A  45
SER A  40
LEU A  69
LEU A  99
 None
 1.08A 4n09A-4rz2A:
3.6		 4n09A-4rz2A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubq BETA-LACTAMASE

(Acinetobacter
baumannii) 		no annotation 4 LEU A  37
SER A 196
LEU A 155
LEU A  13
 None
 0.97A 4n09A-4ubqA:
undetectable		 4n09A-4ubqA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 LEU A 656
SER A 669
LEU A 662
LEU A 618
 None
 1.10A 4n09A-4w8jA:
undetectable		 4n09A-4w8jA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wec SHORT CHAIN
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 LEU A 184
SER A 142
LEU A 244
LEU A 223
 None
NAD  A 301 (-3.6A)
EDO  A 305 (-4.5A)
None
 0.90A 4n09A-4wecA:
7.3		 4n09A-4wecA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8q UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF08713
(DNA_alkylation) 		4 LEU A 152
SER A 163
LEU A 119
LEU A 114
 None
 1.12A 4n09A-4x8qA:
undetectable		 4n09A-4x8qA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yac C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		4 LEU A 185
SER A 144
LEU A 250
LEU A 234
 None
 0.84A 4n09A-4yacA:
7.7		 4n09A-4yacA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU) 		4 LEU A 687
SER A 697
LEU A 704
LEU A 674
 LEU  A 687 ( 0.6A)
SER  A 697 ( 0.0A)
LEU  A 704 ( 0.6A)
LEU  A 674 ( 0.6A)
 1.10A 4n09A-4zkeA:
undetectable		 4n09A-4zkeA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 LEU A   2
SER A  15
LEU A 661
LEU A 666
 GOL  A 803 ( 4.1A)
GOL  A 803 ( 4.6A)
None
None
 0.92A 4n09A-4zlgA:
undetectable		 4n09A-4zlgA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoq INTRACELLULAR SERINE
PROTEASE

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 LEU I 345
SER I 370
LEU I 377
LEU I 330
 None
 1.00A 4n09A-4zoqI:
5.2		 4n09A-4zoqI:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3r IMP-18

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A  54
SER A 213
LEU A 172
LEU A  30
 None
 0.95A 4n09A-5b3rA:
undetectable		 4n09A-5b3rA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpz ANAPC5 PROTEIN

(Xenopus laevis) 		no annotation 4 LEU A  40
SER A  88
LEU A  73
LEU A  65
 None
None
EDO  A 201 (-4.2A)
None
 1.11A 4n09A-5bpzA:
undetectable		 4n09A-5bpzA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 802
SER A 795
LEU A 773
LEU A 790
 None
 0.96A 4n09A-5fm2A:
undetectable		 4n09A-5fm2A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LEU A 735
SER A 730
LEU A 722
LEU A 691
 None
 1.07A 4n09A-5gr8A:
undetectable		 4n09A-5gr8A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvi UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Danio rerio) 		PF00443
(UCH) 		4 LEU A 321
SER A 248
LEU A 486
LEU A 262
 None
 0.97A 4n09A-5gviA:
undetectable		 4n09A-5gviA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 4 LEU A 497
SER A 385
LEU A 373
LEU A 424
 None
 1.07A 4n09A-5h7wA:
undetectable		 4n09A-5h7wA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN

(Klebsiella
pneumoniae) 		PF13407
(Peripla_BP_4) 		4 LEU A 315
SER A 311
LEU A 252
LEU A  49
 None
 1.03A 4n09A-5hsgA:
4.0		 4n09A-5hsgA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1

(Homo sapiens) 		PF01273
(LBP_BPI_CETP) 		4 LEU A 211
SER A 206
LEU A 151
LEU A  73
 None
 1.07A 4n09A-5i7kA:
undetectable		 4n09A-5i7kA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jem CREB-BINDING PROTEIN
INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF09030
(Creb_binding)
PF10401
(IRF-3)
PF11707
(Npa1) 		4 LEU C2096
SER C2092
LEU C2067
LEU A 375
 None
 0.93A 4n09A-5jemC:
undetectable		 4n09A-5jemC:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldd CCZ1

(Chaetomium
thermophilum) 		PF08217
(DUF1712) 		4 LEU B 227
SER B 216
LEU B  27
LEU B 231
 None
 1.00A 4n09A-5lddB:
undetectable		 4n09A-5lddB:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n03 GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT B

(Myxococcus
xanthus) 		no annotation 4 LEU D 148
SER D 177
LEU D  16
LEU D  35
 None
 0.88A 4n09A-5n03D:
3.4		 4n09A-5n03D:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN

(Tribolium
castaneum) 		no annotation 4 LEU A 301
SER A 303
LEU A 344
LEU A 317
 None
 1.11A 4n09A-5oatA:
undetectable		 4n09A-5oatA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A 325
SER A 252
LEU A 496
LEU A 266
 None
 0.91A 4n09A-5ohkA:
undetectable		 4n09A-5ohkA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 4 LEU A 418
SER A 420
LEU A 512
LEU A 333
 None
 0.81A 4n09A-5opqA:
undetectable		 4n09A-5opqA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 3

(Schizosaccharomyces
pombe) 		no annotation 4 LEU A 385
SER A 387
LEU A 408
LEU A 422
 None
 0.94A 4n09A-5oqrA:
undetectable		 4n09A-5oqrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szm PCDHGA8 OR
PROTOCADHERIN GAMMA
A8

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 LEU A 183
SER A 144
LEU A 198
LEU A 125
 None
None
MAN  A 515 (-3.6A)
None
 1.12A 4n09A-5szmA:
undetectable		 4n09A-5szmA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 LEU A 169
SER A 190
LEU A 207
LEU A 214
 None
 1.09A 4n09A-5ux5A:
undetectable		 4n09A-5ux5A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		4 LEU A 402
SER A 400
LEU A 442
LEU A 456
 None
 1.08A 4n09A-5wu3A:
undetectable		 4n09A-5wu3A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		4 LEU A 402
SER A 400
LEU A 442
LEU A 456
 None
 1.03A 4n09A-5wu6A:
undetectable		 4n09A-5wu6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x41 COBALT ABC
TRANSPORTER
ATP-BINDING PROTEIN

(Rhodobacter
capsulatus) 		PF00005
(ABC_tran) 		4 LEU A  37
SER A 196
LEU A 202
LEU A 239
 None
 0.86A 4n09A-5x41A:
undetectable		 4n09A-5x41A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4j NUCLEOPORIN GLE1

(Homo sapiens) 		no annotation 4 LEU B 452
SER B 450
LEU B 512
LEU B 480
 None
 1.07A 4n09A-6b4jB:
undetectable		 4n09A-6b4jB:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c54 NUCLEOPROTEIN

(Zaire
ebolavirus) 		no annotation 4 LEU A  74
SER A  72
LEU A 209
LEU A 203
 None
 0.98A 4n09A-6c54A:
undetectable		 4n09A-6c54A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 4 LEU A 202
SER A 264
LEU A 204
LEU A 235
 None
ACT  A 612 (-2.7A)
None
None
 1.10A 4n09A-6cczA:
2.8		 4n09A-6cczA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G

(Pyrococcus
furiosus) 		no annotation 4 LEU B  66
SER B  68
LEU C  83
LEU F  16
 None
 1.04A 4n09A-6cfwB:
undetectable		 4n09A-6cfwB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cuf -

(-) 		no annotation 4 LEU 7 104
SER 7 102
LEU 7  73
LEU 7  13
 None
 1.11A 4n09A-6cuf7:
undetectable		 4n09A-6cuf7:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft -

(-) 		no annotation 4 LEU B 183
SER B 185
LEU B 153
LEU B 110
 None
 1.10A 4n09A-6dftB:
3.2		 4n09A-6dftB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elc VARIANT SURFACE
GLYCOPROTEIN

(Trypanosoma
brucei) 		no annotation 4 LEU A 131
SER A 379
LEU A 146
LEU A 138
 None
 1.05A 4n09A-6elcA:
undetectable		 4n09A-6elcA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 4 LEU A  26
SER A  24
LEU A  87
LEU A  95
 None
 0.87A 4n09A-6fikA:
undetectable		 4n09A-6fikA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus) 		no annotation 4 LEU M 106
SER M 101
LEU M  73
LEU M 235
 None
3PE  M 505 ( 3.8A)
None
None
 0.88A 4n09A-6g2jM:
undetectable		 4n09A-6g2jM:
11.90